Terpenes are the most diverse class of biomols., with over 50,000 described compounds Fifteen carbon sesquiterpenes are ubiquitous in nature and are known to be effective in a wide range of high value applications including flavors and fragrances, cosmetic products, food ingredients, pharmaceutical products, and insect control. There is rich literature on the use of sesquiterpenes for insect control. Work at the US Centers for Disease Control has demonstrated that nootkatone, the defining flavor and fragrance of grapefruit and also found in Alaskan yellow cedar, is a very effective tick acaricide and repellent. In those studies, it was further demonstrated that low concentrations of nootkatone have the ability to maintain effective acaricidal activity for up to six weeks. In addition to nootkatone, numerous other sesquiterpenes have been shown to control effectively insects such as mosquitoes, ants, fleas, and bedbugs. In spite of their proven efficacy, there has been little com. development of sesquiterpenes as insect control agents due to their lack of availability at com. viable prices. Allylix has developed proprietary technol. for the production of terpenes using synthetic biol. and metabolic engineering of Saccharomyces cerevisiae yeast. This technol. provides the basis for sustainable production of sesquiterpenes and other terpenes from abundant inexpensive raw materials, allowing reliable cost-effective production of these compounds at consistent quality. The production process for nootkatone has been practiced at com. scale, and nootkatone is currently sold in the marketplace. Allylix technol. can also serve as a platform for discovery of new biopesticide products. Using straightforward chem. modification of various terpene scaffolds produced by fermentation, libraries can be generated and tested for insect control and other applications. These technologies provide mechanisms to discover and to produce terpene-based biopesticide products that can compete with conventional pesticides on both and efficacy and an economic basis.