Delving into the Latest Updates on Pars Isotope Co. with Synapse

概览

疾病领域	数量

肿瘤	1

排名前五的药物类型	数量

核素偶联药物	1
放射与诊断药物	1

排名前五的靶点	数量

FAP(成纤维细胞激活蛋白α)	1

关联

1

项与 Pars Isotope Co. 相关的药物

177Lu-FAPI

靶点

FAP

作用机制

FAP调节剂

在研机构

Iran University of Medical Sciences & Health Services [+1]

原研机构

Pars Isotope Co.

在研适应症

转移性胃肠道肿瘤 [+1]

非在研适应症-

最高研发阶段临床1期

首次获批国家/地区-

首次获批日期-

1

项与 Pars Isotope Co. 相关的临床试验

IRCT20241005063266N1 / Suspended临床2期IIT

Investigating the effect of theranostic approach with radiopharmaceuticals technetium 99m prostate membrane specific antigen - Lutchem 177 prostate membrane specific antigen in patients with glioblastoma

开始日期2024-11-21

申办/合作机构

Shiraz University of Medical Sciences

[+1]

100 项与 Pars Isotope Co. 相关的临床结果

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0 项与 Pars Isotope Co. 相关的专利（医药）

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12

项与 Pars Isotope Co. 相关的文献（医药）

2024-07-01·Biomedical Physics & Engineering Express

Optimizing scan time and bayesian penalized likelihood reconstruction algorithm in copper-64 PET/CT imaging: a phantom study

Article

作者: Monsef, Abbas ; Sheikhzadeh, Peyman ; Yazdani, Mohammadreza ; Sadeghi, Fatemeh ; Steiner, Joseph R ; Ghafarian, Pardis

AbstractObjectives: The aim of this study was to evaluate Cu-64 PET phantom image quality using Bayesian Penalized Likelihood (BPL) and Ordered Subset Expectation Maximum with point-spread function modeling (OSEM-PSF) reconstruction algorithms. In the BPL, the regularization parameter

β

was varied to identify the optimum value for image quality. In the OSEM-PSF, the effect of acquisition time was evaluated to assess the feasibility of shortened scan duration. Methods: A NEMA IEC PET body phantom was filled with known activities of water soluble Cu-64. The phantom was imaged on a PET/CT scanner and was reconstructed using BPL and OSEM-PSF algorithms. For the BPL reconstruction, various

β

values (150, 250, 350, 450, and 550) were evaluated. For the OSEM-PSF algorithm, reconstructions were performed using list-mode data intervals ranging from 7.5 to 240 s. Image quality was assessed by evaluating the signal to noise ratio (SNR), contrast to noise ratio (CNR), and background variability (BV). Results: The SNR and CNR were higher in images reconstructed with BPL compared to OSEM-PSF. Both the SNR and CNR increased with increasing β, peaking at

β

= 550. The CNR for all β, sphere sizes and tumor-to-background ratios (TBRs) satisfied the Rose criterion for image detectability (CNR > 5). BPL reconstructed images with β = 550 demonstrated the highest improvement in image quality. For OSEM-PSF reconstructed images with list-mode data duration ≥ 120 s, the noise level and CNR were not significantly different from the baseline 240 s list-mode data duration. Conclusions: BPL reconstruction improved Cu-64 PET phantom image quality by increasing SNR and CNR relative to OSEM-PSF reconstruction. Additionally, this study demonstrated scan time can be reduced from 240 to 120 s when using OSEM-PSF reconstruction while maintaining similar image quality. This study provides baseline data that may guide future studies aimed to improve clinical Cu-64 imaging.

2022-06-01·Microbiology

The Lut Desert and Its Microbial Diversity: Recent Studies and Future Research

作者: Shirsalimian, M. S. ; Amoozegar, M. A. ; Mazidi, S. M.

Abstract: A significant proportion of the Earth surface is covered by deserts.Despite the stressful environmental conditions, deserts can host diverse microbial populations, especially extremophiles.Due to their remarkable adaptive capabilities, extremophiles have been used in biotechnol. and medicine.Understanding microbial diversity in arid environments offers also potential sources of new natural bioactive metabolites.The Lut Desert, located in the eastern part of Iran, is one of the driest and hottest deserts around the world.It presents a collection of unique natural phenomena and geol. records.In this review, we describe the previous efforts to show the microbial diversity in the Lut Desert and highlight their promising applications.

2022-03-01·Current Radiopharmaceuticals

Assessment of Cell Cytotoxicity and Comet Assay on HER2/neu Positive Cell Line Due to 111 In Auger Electrons as DNA-Targeting Radioimmunoconjugate

Article

作者: Hashemizadeh, Miad ; Alirezapour, Behrouz ; Sedeh, Farahnaz Motamedi ; Piroozfar, Behnaz ; Raisali, Gholamreza ; Mirzaii, Mohammad ; Jalilian, Amir Reza

Background:Breast cancer Auger electron therapy is a growing field of study in radioimmunotherapy and oncology research. Trastuzumab, a high affinity-binding monoclonal antibody against HER2/neu is which is over-expressed in breast tumors, is used in radiopharmaceutical development.Objective:In this work, the lethal effects of 111In3+, 111In-DTPA-trastuzumab and 111In-trastuzumab coupled-nuclear localizing sequence peptide (111In-DTPA-NLS-trastuzumab) on malignant cells were studied in vitro.Methods:DTPA-NLS-trastuzumab was prepared using sulfosuccinimidyl-4-(N-maleimidomethyl) cyclohexane-1-carboxylate (sulfo-SMCC) conjugation with NLS peptide in the first step, followed by conjugation with diethylenetriaminepentaacetic acid (DTPA). Both DTPA-trastuzumab and DTPA- NLS-trastuzumab were labeled with 111In followed by purification and quality control techniques. Sk-Br-3 (a HER2/neu+ cell line), was used in the cell viability assessment assay for 11In, 111In-DTPA-trastuzumab and 111In-DTPA-NLS-trastuzumab (3.7 MBq) at 37 ºC. The cytotoxicity of the three species was studied using MTT and comet assay was utilized DNA damage detection.Results:A significant radiochemical purity for 111In-DTPA-NLS-trastuzumab (99.36% ± 0.30%, ITLC) at the DTPA:antibody ratio of 6.90 ± 0.34:1, was obtained. Significant cell viability difference was found for 111In-DTPA-NLS-trastuzumab compared to the other treatments at two-time points. In addition, comet assay demonstrated significant DNA damage at 144 h using 111In-DTPA- NLS-trastuzumab.Conclusion:The results of cell viability and cell death using MTT assay and comet assay, respectively, demonstrate the NLS-peptide effectively facilitates 111In-trastuzumab transport into the HER2/neu positive cancer cell nuclei to impose the radiotherapeutic effects of Auger electrons on DNA leading to cell death.

100 项与 Pars Isotope Co. 相关的药物交易

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100 项与 Pars Isotope Co. 相关的转化医学

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