Delving into the Latest Updates on Atlanthera SASU with Synapse

概览

关联

2

项与 Atlanthera SASU 相关的药物

Ifosamide

异环磷酰胺

靶点

DNA

作用机制

DNA抑制剂 [+1]

在研机构

Baxter International, Inc. [+3]

原研机构

Baxter International, Inc.

在研适应症

儿童恶性实体瘤 [+15]

非在研适应症

急性淋巴细胞白血病 [+2]

最高研发阶段批准上市

首次获批国家/地区

法国

首次获批日期1976-01-01

12B80 (ATLANTHERA)

靶点-

作用机制-

在研机构-

原研机构

Atlanthera SASU

在研适应症-

非在研适应症

骨癌

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

100 项与 Atlanthera SASU 相关的临床结果

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0 项与 Atlanthera SASU 相关的专利（医药）

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2

项与 Atlanthera SASU 相关的文献（医药）

2019-12-01·Synthesis

Synthesis of 13C-Labeled Steroids

作者: Dénès, Fabrice ; Farard, Julien ; Lebreton, Jacques

Due to the wide spectrum of biological activities of steroids, the detection and quantification of steroidal residues in various biological materials are crucial for drug development, doping prevention, and environmental protection. In addition, the analytical technique of stable isotopic dilution (SID) by Liquid Chromatography-Mass Spectrometry (LC-MS) requires 13C-labeled steroids as standards to provide accurate and reproducible steroid quantification. In this context, the synthesis of 13C-labeled steroids is reviewed. The approaches based on partial synthesis starting from commercially available steroids have been, by far, the most commonly employed strategy.1 Introduction2 Hemisynthesis of 13C3-Labeled Steroids via Partial Degradation of the A Ring2.1 Degradation of the A Ring to an Enol Lactone2.1.1 Introduction of 13C Atom(s) via Claisen Condensation: Turner’s Strategy2.1.2 Introduction of 13C Atom(s) with 13C-Labeled 5-(Diethylphosphono)pentan-2-one Ethylene Ketal Based on the Fujimoto–Belleau Reaction2.2 Degradation of the A Ring and Introduction of 13C Atom(s) with [13C3]-1-(Triphenylphosphoranylidene)propan-2-one3 Construction of the A Ring from an α,β-Unsaturated Ketone with 13C-Labeled 1-Iodo-3,3-(ethylenedioxy)butane as Electrophile4 Construction of the A and B rings: Stork’s Strategy5 Hemisynthesis with Introduction of 13C Atom(s) in the C17 Side Chain6 Conclusion

Anticancer Research

Treatment of bone metastasis in prostate cancer: efficacy of a novel polybisphosphonate

作者: Marquez, Marcela ; Schroeder, Torbjoern ; Nilsson, Sten ; Le Bot, Ronan ; Daubine, Florence ; Holmberg, Anders R.

Aim: To investigate the in vivo efficacy of a novel polybisphosphonate (ODX) in the treatment of bone metastasis from prostate cancer.Material and methods: A rat prostatic carcinoma model was used.Forty-two rats (21 control, 21 treatment) had induction of bone lesions through injection of AT6.1 cells into the distal medullar cavity of long bones (right femur).At day 21 post injection, radiographs were taken and tumor score (severity of lesions, 0-4) and tumor incidence (score >0) were determinedTreatment started at day 23 and lasted until day 49 (four i.v. administrations of ODX during four weeks).Results: ODX reduced the severity of the lesions compared to the control group.Forty-seven percent of the treated rats had regression of their lesions at the study end, including four rats showing disappearance of the lesions i.e. score 0.Conclusion: In spite of a relatively short treatment period with only four administrations, ODX showed significant efficacy (p=0.0023), with inhibition of tumor progression and osteolysis.The results are encouraging, confirming previous in vitro studies.Clin. research is pending on patients with bone metastasis from castration-resistant prostate cancer.

100 项与 Atlanthera SASU 相关的药物交易

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100 项与 Atlanthera SASU 相关的转化医学

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