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疾病领域	数量

免疫系统疾病	1

排名前五的药物类型	数量

化学药	1

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1

项与 Tenri University 相关的药物

Sodium Hyaluronate

玻璃酸钠

靶点-

作用机制-

在研机构

山东博士伦福瑞达制药有限公司 [+8]

原研机构

Seikagaku Corp.

在研适应症

角膜移植排斥反应 [+11]

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区

日本

首次获批日期1986-11-29

100 项与 Tenri University 相关的临床结果

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0 项与 Tenri University 相关的专利（医药）

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190

项与 Tenri University 相关的文献（医药）

2024-10-01·Neurological Sciences

Novel insights into presenilin 1 mutation associated with a distinctive dementia phenotype and cotton wool plaques

Article

作者: Mimuro, Maya ; Wake, Akito ; Hori, Akira ; Fukuoka, Tomoya ; Yoshida, Mari ; Hashizume, Yoshio ; Watanabe, Ichiro ; Yamamoto, Takayuki ; Yamagata, Hidehisa D ; Miyazaki, Tatsuhiko ; Akatsu, Hiroyasu ; Miki, Tetsuro ; Sato, Naoyuki ; KImura, Naoto ; Kamada, Kazuo

BACKGROUNDThe mutations in the presenilin 1 gene (PSEN1) are the main cause of familial Alzheimer's disease. PSEN1 mutations affect amyloid-beta peptide production, which accumulates in the brain as senile plaque and cotton wool plaques (CWPs) and relates to other neurodegenerative disorders. Here we report the second case of the PSEN1 G266S mutation, which showed distinctive neuropathological features, including abundant CWPs. Lewy body pathology, and altered amyloid-beta production.METHODUsing the proband's samples, we performed genetic analysis of the PSEN1, APP, MAPT, and APOE genes, histopathological and immunohistochemical analysis of the brain tissue, and biochemical analysis of Aβ production in COS cells transfected with wild-type or mutant PSEN1.RESULTSThe patient presented with memory loss, abnormal behavior, and visual hallucinations. Brain scans showed reduced blood flow, mild atrophy, and white matter lesions. Genetic analysis revealed a heterozygous mutation at codon 266 (G266S) of PSEN1 and polymorphism of MAPT (Q230R). The brain had many CWPs, severe cerebral amyloid angiopathy (CAA), senile plaque, Lewy bodies, and neurites. Electron microscopy displayed myelinated fiber degeneration, mitochondrial damage, and amyloid fibrils in the white matter. The production level of Aβ42 in PSEN1 G266S-transfected cells significantly increased.CONCLUSIONOur findings suggest that the PSEN1 G266S mutation may cause a heterogeneous clinical and pathological phenotype, influenced by other genetic or environmental factors.

2024-07-05·Medicine

Awareness of cancer and its associated factors for parents of adolescents and young adults: A cross-sectional study

Article

作者: Fujisaka, Yasuhito ; Minamiguchi, Yoko ; Hayashi, Naoko ; Suzuki, Kumi ; Fukawa, Akiko ; Tsuda, Yasuhiro ; Yamanaka, Masako ; Tomari, Yuko ; Yamauchi, Eiko ; Doi, Tomoki

Cancer is a common health problem worldwide. Early cancer education for adolescents and young adults (AYAs) is important for the prevention or early detection of cancer. In this questionnaire-based cross-sectional study, we examined the cancer awareness among parents of AYAs. Japanese adults with junior or senior high school children were included in this study. The cancer awareness measure (CAM) was used to assess cancer awareness, and the survey was conducted in December 2021. Warning signs, barriers to seeking help, and risk factors were surveyed using an online anonymous questionnaire. In addition, personal information, the presence of other cancer survivors, attendance at cancer seminars, conversations with children about cancer, interest in cancer education for children, and previous cancer screening were surveyed. A t-test or Spearman correlation coefficient was used to compare the total CAM scores for the individual factors. The relationship between cancer-screening behavior and individual factors was analyzed using the χ2 test. In addition, multiple regression analysis or logistic regression analysis was used to identify the factors influencing cancer awareness or cancer-screening behavior. Responses were obtained from the 612 participants. The mean CAM score was 3.7 for cancer warning signs, 4.3 for barriers to seeking help, and 6.5 for risk factors. Cancer warning signs were associated with gender and the presence of a spouse, family member, or friend who had experienced cancer. Barriers to seeking help were associated with age, gender, and education, while risk factors were associated with gender, education, and conversations about cancer with children. Moreover, these scores were associated with each cancer screening behavior. Cancer awareness among Japanese adults with AYAs was influenced by gender, academic background, occupation, the presence of cancer survivors around them, and whether they had conversations about cancer with their children, as well as their cancer screening behavior.

2024-06-30·Chagyo Kenkyu Hokoku (Tea Research Journal)

Toward the Proposal for a Tea Education Program to Preserve Cultural Heritage Based on Analysis of Elementary School Students' Written Feedback of Tea Classes

作者: Saito, Ryo ; Konishi, Sara ; Kido, Ayae

100 项与 Tenri University 相关的药物交易

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100 项与 Tenri University 相关的转化医学

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