The refined terminal "BaHunYe" of Qingkailing injection was ultrafiltrated by 5 KD and 10 KD ultrafiltration membranes and analyzes the effect on content components of the two grades ultrafiltration membranes. The results indicated: 10 KD ultrafiltration membranes can be used in terminal ultrafiltration of Qingkailing injection, it is beneficial to improve product quality; but 5 KD ultrafiltration membranes will loss more content, the color and luster looks shallow, and the indexes of relevant inspection items are difficult to control within specifications, needs to a further studied.