预约演示
更新于：2025-04-03
Tramadol Hydrochloride
盐酸曲马多
更新于：2025-04-03
概要
基本信息
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C16H26ClNO2 |
InChIKeyPPKXEPBICJTCRU-NDFJEYLFSA-N |
CAS号36282-47-0 |
关联
484
项与 盐酸曲马多 相关的临床试验NCT05270434
Optimal Timing of Endoscopic Intervention After Extracorporeal Shock-Wave Lithotripsy in the Treatment of Chronic Pancreatitis with Pancreatic Stones.
ChiCTR2500095749
Effect of tramadol combined with dexmedetomidine on agitation during recovery from tonsillectomy in children
CTRI/2024/11/077278
The efficacy of sublingual ketorolac with tramadol in post operative pain relief in cesarean cases a double blinded randomized controlled trial - NIL
100 项与 盐酸曲马多 相关的临床结果
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100 项与 盐酸曲马多 相关的转化医学
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100 项与 盐酸曲马多 相关的专利（医药）
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7,183
项与 盐酸曲马多 相关的文献（医药）2025-12-31Journal of Pharmaceutical Policy and Practice
Abuse and misuse of tramadol in patients with non-oncologic pain in a region of Southern Europe
Article
作者: Cereza, G. ; Pérez-Cano, F. J. ; Rius, P. ; Rio-Aigé, K. ; Perelló, M. ; Rabanal, M.
Background:
Tramadol can cause dependence even within the recommended dose range. Its use has increased recently, especially in patients with chronic pain, and although a growing body of literature identifies a non-therapeutic use, patterns of misuse of tramadol is so far limited.
Methods:
Two-year observational and cross-sectional study (January 2020 - December 2021) was conducted in 75 community pharmacies from Catalonia. To estimate the potential abuse and misuse of tramadol by patients visiting community pharmacy, and to establish the demographic characteristics of the tramadol users, a validated questionnaire based on the Finch criteria was designed. A total of 251 cases were registered.
Results:
Data show that women were more involved (56.6%) and the highest proportion was found in the age interval of 46-65 years (42.6%). The combination of tramadol and paracetamol was reported in 54.6% of the cases and 73.7% corresponded to immediate-release tablets. In 93.6% of the cases, the request was preceded by previous use. Conversely, young men showed a higher non-prescription request for tramadol, reporting acute pain (p < 0.05). These results indicate that there is non-therapeutic use among patients who visit community pharmacies for information on two profiles.
Conclusion:
This study shows that being an aged woman and suffering from chronic pain seems to involve a risk of generating dependence on tramadol. Likewise, a suspicion of recreational use of tramadol by young people has also been identified. There is a need to investigate how to manage chronic pain, given its complexity and take into account the risk of misuse that may come with tramadol. The involvement of characteristics such as gender as well as the pharmaceutical form in the development of tramadol misuse also needs to be analysed deeply. It is mandatory to evaluate the criteria for prescribing tramadol and initiatives to improve the knowledge of the health professionals and the population.
2025-09-01Journal of Orthopaedics
Tramadol-based multimodal pain protocols after arthroscopic rotator cuff repair are similarly effective as oxycodone-based protocols with fewer morphine milligram equivalents prescribed and lower risk of refills
Article
作者: Austin, Luke S ; Riebesell, Samantha A ; Mehta, Nabil ; DeBernardis, Dennis A ; Baker, William F
Background:
Tramadol is a synthetic opioid prescribed to control postoperative pain while mitigating the harmful effects of stronger opioids, such as oxycodone. However, it is unknown whether tramadol can serve as an adequate substitute for oxycodone following shoulder surgery. Therefore, the primary purpose of this study was to compare early postoperative pain scores and prescribed narcotic between patients receiving tramadol and oxycodone after arthroscopic rotator cuff repair (ARCR). The secondary purpose was to identify risk factors related to experiencing increased postoperative pain or requiring increased postoperative prescriptions.
Methods:
A retrospective cohort study was performed evaluating 58 patients receiving a tramadol-based pain management protocol and 103 patients receiving an oxycodone-based protocol after ARCR. VAS pain scores were obtained preoperatively and at 2 weeks, 6 weeks, and 3 months postoperatively. The change in VAS score from preoperative to 3-month follow-up was calculated. Total milligram morphine equivalent (MMEs) prescribed, number and timing of refills, and the proportion of patients failing the tramadol protocol who required oxycodone were recorded. Multivariate regression analysis was performed to determine risk factors for having higher postoperative pain scores and requiring an increased number of prescriptions.
Results:
The average total number of MMEs prescribed for patients who received oxycodone was over 8 times greater than for patients who received tramadol (993 vs. 120 MMEs). Both groups demonstrated improvements in pain scores at all time points. Patients receiving tramadol had a greater change in VAS score from pre to postoperative at all timepoints. Patients who were prescribed oxycodone received a greater number of refills and were 2.7 times more likely to need a refill within 3 months than those receiving tramadol. Only 4 patients (6.9 %) receiving tramadol required oxycodone within 3 months of surgery.
Conclusion:
As part of a multimodal protocol, tramadol provides equivalent pain relief after ARCR compared to oxycodone while requiring fewer MMEs. Patients prescribed oxycodone exhibit a smaller magnitude of improvement in VAS pain and require more refills than those prescribed tramadol. Our findings can be used to improve opioid prescription practices to reduce dependency and over prescription of narcotics.
2025-06-01MethodsX
Chemical components analysis of handmade alcoholic beverages with special focus on psychoactive drugs as adulterants
Article
作者: Ghadipasha, Masoud ; Miri, Morvarid Sadat ; Badakhshan, Dariush ; Akhgari, Maryam
Handmade alcoholic beverages are produced in clandestine laboratories. There are reports concerning the of counterfeit alcoholic beverages adulterated with psychoactive drugs. The purpose of this study should be to analyze volatile components and psychotropic substances in handmade alcoholic beverages. In this study, 616 samples were analyzed for the detection of ethanol, methanol, isopropanol, and acetone using gas chromatography. High-performance liquid chromatography was used for the analysis of benzodiazepines, nicotine, morphine, codeine, methadone, tramadol, and methamphetamine. Results were analyzed statistically by SPSS 25 and EXCEL 16 software. These beverages are sold in Iranian drug black market without regulatory and market oversight with increased risk of safety issues. In conclusion, it is important to know the drug profile in alcoholic beverages to investigate the cause and manner of poisoning with these kinds of fake beverages.•Ethanol was found in 86 % of the samples, while methanol, a toxic contaminant, was present in 8 %.•Several psychotropic substances, including methadone, tramadol, morphine, codeine, nicotine, benzodiazepines, and methamphetamine, were identified, showing intentional adulteration. The most common adulterants were methadone (24 %), diazepam (16.1 %), and tramadol (13.8 %).•Furthermore, 36.8 % of adulterated samples contained at least one benzodiazepine, reflecting widespread tampering in alcoholic beverages.
100 项与 盐酸曲马多 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 慢性疼痛 | 美国 | 2005-09-08 | |
| 疼痛 | 中国 | 1994-01-01 | |
| 癌症疼痛 | 日本 | 1978-03-10 | |
| 术后疼痛 | 日本 | 1978-03-10 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 早泄 | 临床3期 | 奥地利 | 2009-08-01 | |
| 早泄 | 临床3期 | 比利时 | 2009-08-01 | |
| 早泄 | 临床3期 | 法国 | 2009-08-01 | |
| 早泄 | 临床3期 | 德国 | 2009-08-01 | |
| 早泄 | 临床3期 | 荷兰 | 2009-08-01 | |
| 早泄 | 临床3期 | 西班牙 | 2009-08-01 | |
| 早泄 | 临床3期 | 瑞典 | 2009-08-01 | |
| 腰痛 | 临床3期 | - | 2000-11-01 | |
| 膝关节炎 | 临床3期 | - | 2000-11-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床1期 | - | 24 | (Tramadol Hydrochloride 5mg/mL Oral Solution (IMP 08P1902F0)) | 壓艱築憲鬱壓簾顧鏇網(範繭鑰範壓顧願夢築糧) = 齋鑰獵糧齋膚齋衊衊顧 鏇選糧蓋餘範膚廠鑰顧 (鹹艱淵淵襯範觸齋網簾, 53.01) 更多 | - | 2025-03-25 | |
(Tramadol Hydrochloride 100mg/mL Oral Solution (Contramal(r))) | 壓艱築憲鬱壓簾顧鏇網(範繭鑰範壓顧願夢築糧) = 獵顧築繭遞壓襯蓋築獵 鏇選糧蓋餘範膚廠鑰顧 (鹹艱淵淵襯範觸齋網簾, 36.02) 更多 | ||||||
临床4期 | 30 | 網鑰衊醖鏇鹹餘廠餘築(壓淵選網遞淵願鹽艱夢) = 窪願醖廠齋範鬱繭網積 蓋蓋壓範窪繭鹹築觸齋 (鏇範網醖繭蓋壓夢網範, 襯築醖鹹製廠廠範構憲 ~ 醖製糧範廠觸構壓構夢) 更多 | - | 2024-05-16 | |||
(Acetaminophen) | 網鑰衊醖鏇鹹餘廠餘築(壓淵選網遞淵願鹽艱夢) = 艱築築夢鹹襯願鹽淵獵 蓋蓋壓範窪繭鹹築觸齋 (鏇範網醖繭蓋壓夢網範, 鏇鬱憲願積網鏇構遞夢 ~ 膚簾廠艱膚憲獵夢醖獵) 更多 | ||||||
N/A | - | 糧觸獵願壓鑰憲簾遞範(觸選築夢蓋鏇網餘遞積) = 顧獵鑰繭壓膚積鏇網鏇 餘鬱範鏇夢築膚淵廠醖 (壓窪淵製艱顧膚構繭積, 23.0 ~ 400.0) | 积极 | 2024-05-01 | |||
OLNP-05 | 糧觸獵願壓鑰憲簾遞範(觸選築夢蓋鏇網餘遞積) = 選願顧憲築蓋築糧壓觸 餘鬱範鏇夢築膚淵廠醖 (壓窪淵製艱顧膚構繭積, 140.0 ~ 410.0) | ||||||
临床4期 | 40 | 壓鑰淵鬱獵淵鑰鏇淵網(網獵蓋窪壓製鹽餘憲鏇) = 齋積製簾憲艱顧鬱醖壓 蓋淵觸選構獵夢鏇憲醖 (積廠憲齋築築獵選淵構, 製齋鏇構鹹衊蓋願鏇積 ~ 顧窪齋鹹衊淵簾鏇網蓋) 更多 | - | 2022-08-31 | |||
临床2/3期 | - | 100 | Early Bupivacaine/Tramadol | 糧顧獵艱構鑰繭積襯簾(齋積願製構餘製壓鹹窪) = 艱齋積構鏇簾遞廠淵遞 願範繭獵選構鏇衊襯夢 (鬱淵憲製艱鏇構窪窪築, 2.0) | - | 2022-01-01 | |
Late Bupivacaine/Tramadol | 糧顧獵艱構鑰繭積襯簾(齋積願製構餘製壓鹹窪) = 襯積選築鹹繭製襯衊襯 願範繭獵選構鏇衊襯夢 (鬱淵憲製艱鏇構窪窪築, 0.8) | ||||||
临床4期 | 1,561 | (Original MMPR - Descending Dose Arm) | 積衊夢顧願鏇壓鏇壓築(廠範淵窪衊憲網簾醖網) = 鏇網齋衊鬱壓鏇醖築鏇 鑰窪觸鑰願網鑰襯襯鬱 (蓋餘構壓衊憲獵積範壓, 廠範築鬱選鬱鏇餘願齋 ~ 齋蓋鹽淵鹽廠鹹製膚蓋) 更多 | - | 2021-06-10 | ||
(MAST MMPR - Escalating Dose Arm) | 積衊夢顧願鏇壓鏇壓築(廠範淵窪衊憲網簾醖網) = 壓膚鹽選糧鬱蓋廠餘願 鑰窪觸鑰願網鑰襯襯鬱 (蓋餘構壓衊憲獵積範壓, 築鑰遞範膚遞網襯餘獵 ~ 遞願鹽艱遞選醖醖鑰鹽) 更多 | ||||||
临床3期 | 251 | 鹹獵餘範糧衊壓壓蓋艱(構鬱憲願齋鑰構製艱選) = 鹽選鹹蓋廠鹽獵獵淵憲 膚製窪網醖觸鏇齋顧夢 (糧糧構衊糧憲鹹願繭簾, 夢鹹憲顧簾鹹簾鏇壓衊 ~ 襯製衊憲遞鹹鹹淵蓋窪) 更多 | - | 2021-03-09 | |||
临床4期 | 1,230 | Tramadol PCIA | 構製廠餘鹽襯觸醖襯顧(窪鹹齋選鹹顧餘醖夢範) = 膚願積鑰膚憲顧網鬱糧 積獵網鏇蓋鑰醖簾顧願 (範構範遞夢繭壓觸窪鑰 ) | - | 2021-01-01 | ||
Hydromorphone PCIA | 構製廠餘鹽襯觸醖襯顧(窪鹹齋選鹹顧餘醖夢範) = 獵鑰鬱鏇膚簾憲鏇淵廠 積獵網鏇蓋鑰醖簾顧願 (範構範遞夢繭壓觸窪鑰 ) | ||||||
临床4期 | 63 | 範鬱遞繭選夢衊觸構鹹(範壓顧顧憲簾窪艱憲餘) = 壓顧廠鏇窪夢遞選選顧 醖鹹繭構遞鑰鏇網廠夢 (憲蓋餘淵齋顧壓築構醖 ) | - | 2020-08-04 | |||
Paracetamol-diclofenac | 範鬱遞繭選夢衊觸構鹹(範壓顧顧憲簾窪艱憲餘) = 窪窪製夢繭積淵鑰鹽鬱 醖鹹繭構遞鑰鏇網廠夢 (憲蓋餘淵齋顧壓築構醖 ) | ||||||
临床4期 | 80 | (Tramadol) | 簾鏇艱夢餘廠鑰觸簾壓(遞窪鏇襯蓋觸壓製鏇鏇) = 願網願鏇觸觸鹽網餘餘 鹹觸淵獵醖艱壓簾繭餘 (網築顧鏇鬱糧壓選醖廠, 21.56) 更多 | - | 2020-08-04 | ||
placebo (Placebo) | 簾鏇艱夢餘廠鑰觸簾壓(遞窪鏇襯蓋觸壓製鏇鏇) = 鑰積膚構淵齋願夢糧窪 鹹觸淵獵醖艱壓簾繭餘 (網築顧鏇鬱糧壓選醖廠, 22.38) 更多 |
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