Delving into the Latest Updates on Indian Institute of Integrative Medicine with Synapse

概览

疾病领域	数量

肿瘤	7
感染	6
神经系统疾病	3
免疫系统疾病	2
内分泌与代谢疾病	1

排名前五的药物类型	数量

小分子化药	16
中药	2
未知	1
化学药	1

排名前五的靶点	数量

PI3Kα(磷脂酰肌醇3-激酶α)	2
EHMT2	1
mTOR(丝氨酸/苏氨酸蛋白激酶mTOR)	1
IL-6(白细胞介素-6)	1
Tubulin(微管蛋白)	1

关联

27

项与 Indian Institute of Integrative Medicine 相关的药物

IIIM-4Q

靶点

mTOR

作用机制

mTOR抑制剂

在研机构

Indian Institute of Integrative Medicine

原研机构

Indian Institute of Integrative Medicine

在研适应症

肿瘤

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

IIIM-985

靶点-

作用机制-

在研机构

Indian Institute of Integrative Medicine

原研机构

Indian Institute of Integrative Medicine

在研适应症

肿瘤

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

IIIM-211

靶点-

作用机制-

在研机构

Indian Institute of Integrative Medicine

原研机构

Indian Institute of Integrative Medicine

在研适应症

结核

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

4

项与 Indian Institute of Integrative Medicine 相关的临床试验

CTRI/2008/091/000247

/ Not yet recruiting临床2期

COMPARATIVE EVALUATION OF ACTEOSIDE AND SILYMARIN AS HEPATOPROTECTIVE AGENTS IN ACUTE HEPATITIS PATIENTS-A RANDOMIZED PROSPECTIVE OPEN FRAME STUDY

开始日期2008-12-15

申办/合作机构

Government Medical College Jammu

[+1]

CTRI/2008/091/000090

/ Not yet recruiting临床2期IIT

A double blind, placebo controlled comparative, randomized study to evaluate efficacy & Safety of Colebrookea Oppositifolia (Aceteoside) in acute hepatitis A/B Patients.

开始日期2008-07-15

申办/合作机构

Council of Scientific & Industrial Research

[+1]

CTRI/2008/091/000052

/ Not yet recruiting临床2期IIT

A Proof of Concept prospective, double-blind, placebo-controlled, randomized clinical trial to assess the effects of PHP- Cancer in improving quality of life in patients receiving chemotherapy for treatment of breast cancer

开始日期2008-05-01

申办/合作机构

Council of Scientific & Industrial Research

[+1]

100 项与 Indian Institute of Integrative Medicine 相关的临床结果

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0 项与 Indian Institute of Integrative Medicine 相关的专利（医药）

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520

项与 Indian Institute of Integrative Medicine 相关的文献（医药）

2025-03-01·Plant Physiology and Biochemistry

A transplantation study in the high-altitude ecosystem of Ladakh suggests site-specific microenvironment is key for physiological adaptation than altitude

Article

作者: Ali, Villayat ; Vyas, Dhiraj

Transplantation experiments conducted in high altitude ecosystems are rising as key strategy to examine the response of individual plant transplanted across distinct elevations. However, plant physiological and biochemical performance in response to changes in abiotic factors across different species and mountain ranges is still lacking. So in the present study, we have made an attempt to link the physiological performance with that of altitudinal gradient in Ladakh by transplanting Lepidium latifolium at four different altitudinal sites. The plant was found to maintain photosynthesis even at high altitudes by modulating photochemical efficiency of photosystem II. Various physiological processes including performance index (PI_ABS), increase in energy fluxes, closing of the reaction centres and decrease in chlorophyll content play a crucial role in the adaptation of this plant. The efficient and dynamic non-photochemical quenching (NPQ) involving carotenoids particularly zeaxanthin mediated dissipation of excess light energy at high altitudinal sites of Ladakh led the plant to withstand with extremely strong light radiation. As a photoprotective mechanism, decreases in chlorophyll content and increase in carotenoids could lead to a reduction in the absorption of high light energy and avoid photo damage to the chloroplasts. Higher content of redox metabolites such as GSH, ASC, GSH/GSSG ratio and ASC/DHA ratio in plants transplanted at high altitudinal sites further suggests the resilience ability of Lepidium latifolium against harsh environmental stresses. Furthermore, increase in glucosinolate content in plants transplanted at high altitudes suggests the involvement of GLS in the establishment of Lepidium latifolium in Ladakh. Overall, no specific altitudinal trend was observed in the present study indicating the adaptation strategy of Lepidium latifolium to different altitudinal sites can be attributed to the combined effects of multiple environmental factors/microenvironment.

2025-01-09·Journal of Chromatographic Science

Development and Validation of Fast and Sensitive RP-HPLC Stability-Indicating Method for Quantification of Piroxicam in Bulk Drug

Article

作者: Bhardwaj, Monika ; Kumar, Sandeep ; Grover, Parul ; Nagarajan, K ; Chauhan, Vikas

AbstractA simple, rapid, sensitive, and cost-effective green solvent-assisted reverse-phase high-performance liquid chromatographic technique, coupled with a photodiode array detector, was developed and validated for the estimation of piroxicam (PRXM). The chromatographic separation was achieved by using a C-18 (250 × 4.6) mm, 5-μm stationary phase and a mobile phase consisting of methanol and 0.1% ortho-phosphoric acid in water in a ratio of (80:20) v/v at a flow rate of 1 ml/min. The detection was carried out at a wavelength of 254 nm with a constant injection volume of 10 μL throughout the analysis. The calibration curve was observed to be linear over the optimum concentration range of 50–300 μg mL−1, with an R2 value of 0.9995. The developed method was validated as per the International Council for Harmonisation (ICH) Q2 (R1) guideline. Various parameters like selectivity/specificity, accuracy/recovery, linearity, precision, detection limit, quantitation limit, robustness and stability of analyte in solution were performed for the method validation. The PRXM was evaluated under stressed conditions, including acidic, basic, oxidative, thermal and photolytic, as per ICH Q1 (R2) guidelines. Significant degradation was observed in acidic and basic degradation conditions. Conversely, the drug substance showed stability when exposed to oxidative, photolytic and thermal degradation conditions.

2025-01-01·Medicinal Chemistry Research

Synthesis and in vitro antiproliferative evaluation of novel drimane oxepinyl triazoles from labdane diterpene sclareol

作者: Ahmed, Manzoor ; Yousuf, Syed Khalid ; Hussain, Gulzar ; Shukla, Sanket K. ; Chowdhary, Sundas

A series of new oxepinyl triazoles were synthesized using labdane diterpene sclareol as a template.The synthesis process involved several steps including oxidation, oxetane ring opening, deacetylation, tosylation, and azidation followed by Huisgens 1,3-dipolar cycloaddition reaction with different alkynes.The newly synthesized compounds were confirmed using 1H NMR and 13C NMR.These novel drimane oxepinyl triazoles derived from labdane diterpene sclareol were evaluated for their antiproliferative efficacy in colon (HCT-116), breast (MCF-7), and lung (A-549) cancer cell lines.Compound 14m demonstrated significant cytotoxic effects in all tested cell lines with an IC50 of 16 μM.Initial investigations suggested that the compound induced apoptosis and inhibited cancer cell proliferation, indicating the potential of drimane oxepinyl triazoles as promising therapeutic agents for various cancers.

100 项与 Indian Institute of Integrative Medicine 相关的药物交易

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100 项与 Indian Institute of Integrative Medicine 相关的转化医学

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2025年05月09日管线快照

管线布局中药物为当前组织机构及其子机构作为药物机构进行统计，早期临床1期并入临床1期，临床1/2期并入临床2期，临床2/3期并入临床3期

药物发现

1

19

临床前

其他

7

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当前项目

药物(靶点)	适应症	全球最高研发状态

IIIM-941 ( NLRP3 )	帕金森病更多	临床前
IIIM-985	肿瘤更多	临床前
IIIM-368/15 ( CDK2 x CDK9 )	结肠癌更多	临床前
IIIM-017	结核更多	临床前
IIIM-4Q ( mTOR )	肿瘤更多	临床前