Delving into the Latest Updates on 湖北理工学院 with Synapse

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疾病领域	数量

肿瘤	1

排名前五的药物类型	数量

小分子化药	1

排名前五的靶点	数量

PRKDC(DNA依赖-蛋白激酶)	1

关联

1

项与湖北理工学院相关的药物

SK-10(Wenzhou Medical University)

靶点

PRKDC

作用机制

PRKDC抑制剂

在研机构

温州医科大学 [+2]

原研机构

温州医科大学

在研适应症

肿瘤

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

100 项与湖北理工学院相关的临床结果

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0 项与湖北理工学院相关的专利（医药）

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1,425

项与湖北理工学院相关的文献（医药）

2025-08-01·Journal of Colloid and Interface Science

Harnessing S-scheme BiOCl/COF heterojunctions for sustainable and efficient photocatalytic hydrogen peroxide synthesis under visible light

Article

作者: Yuan, Chengcheng ; Zhang, Yong ; Sun, Changhong ; Yu, Jiaguo ; Zhang, Liuyang ; Zhang, Jie

Photocatalytic hydrogen peroxide production offers a greener alternative, but its efficiency is limited by high carrier recombination. Covalent organic frameworks, with their highly ordered structures and tunable properties, are promising photocatalysts. However, their application in H₂O₂ production has been constrained by the lack of effective strategies to enhance catalytic activity. In this study, BiOCl/COF (TFPB-BPY) S-scheme heterojunctions were prepared via a simple in-situ growth method. The heterojunction exploits the nitrogen-rich architecture and charge transport of the COF, combined with the broad light absorption and internal electric field of BiOCl. This synergy enables superior visible light absorption, efficient charge separation, and suppressed recombination. Mechanistic studies confirmed the S-scheme mechanism as the key to its enhanced performance. This work provides a scalable and eco-friendly strategy for improving COF-based photocatalysts through S-scheme heterojunctions, offering a pathway for sustainable H₂O₂ production and advancing the rational design of photocatalysts for green energy applications.

2025-07-01·Journal of Magnetism and Magnetic Materials

Tailoring the electronic and magnetic properties of AA-stacked ZnO bilayer by engineering covalently bonded F/N-intercalation or introducing SiC substrate

作者: Gao, Yanfeng ; Xiong, Zhihua ; Cui, Yuanyuan ; Hu, Hongduo ; Wang, Aiping ; Chen, Lanli

To meet the current requirements for diluted magnetic semiconductors, it is essential to design the materials with high stability and spin polarization for promoting the development of spintronic devices.Amelioration on the properties of two-dimensional ZnO bilayers for high-performance optoelectronic and spintronic remains a significant challenge and is highly anticipated.Herein, we systematically investigated the electronic structures and magnetic properties of AA-stacked ZnO bilayers through the first-principles calculations, focusing on the effects of covalently bonded F/N-intercalation and the introduction of SiC substrate.The results indicate that pristine ZnO BL, F@ZnO, N@ZnO bilayer and ZnO/SiC heterostructure exhibit dynamical, and mech. and thermal stability.F@ZnO and N@ZnO exhibit magnetic properties, and the magnetic moments are 0.659 μ_B and 1.0 μ_B, which are primarily derived from O-2p and N-2p orbitals, resp.F@ZnO exhibits half-metallic magnetic characteristics, whereas N@ZnO displays metallic features at high intercalation concentrations up to 100%.The stable half-metallicity originates from a spontaneous phase transition driven by Stoner instability due to the high d. of states peak near the Fermi level.In ZnO/SiC heterostructure, one of the ZnO layers adjacent to the SiC layer becomes buckled with a height of 0.891 Å, while the other ZnO layer, situated farther from the SiC layer, remains planar.Furthermore, the system undergoes the transition from a nonmagnetic state to a ferromagnetic state due to the introduction of C atoms.These findings provide a new platform for designing 2D magnetic thin films, which could hold potential for enhancing the application of ZnO materials in optoelectronic and spintronic devices.

2025-07-01·Journal of Hazardous Materials

Methylene blue method for analysis of perfluoroalkyl substances (PFAS): Effect of the molecular structure of PFAS compounds

Article

作者: Wang, Dongliang ; Liu, Guansheng ; Zhong, Hua ; Tang, Xiaojing

This study evaluates the methylene blue method for rapid and cost-effective analysis of perfluoroalkyl substances (PFAS). By employing three perfluorosulfonic acids (PFSAs) (perfluorooctanesulfonic acid (PFOS), perfluorohexanesulfonic acid (PFHxS) and perfluorobutanesulfonic acid (PFBS)), three perfluorocarboxylic acids (PFCAs) (perfluorooctanoic acid (PFOA), perfluorohexanoic acid (PFHxA) and perfluorobutanoic acid (PFBA)) and two non-fluorinated compounds (sodium 1-octanesulfonate (SOS) and octanoic acid (OA)), the impact of PFAS structure, specifically polar group type, carbon chain length and fluorine substitution, on the efficacy of the method was assessed. The results showed that PFSAs produced reliable calibration curves (R² > 0.99) across all pH levels due to strong dissociation of the -SO₃H group. In contrast, PFCAs exhibited pH-sensitive performance in that PFOA (C8) showed good linearity (R² > 0.99) at pH ≥ 4, while shorter-chain PFHxA (C6) and PFBA (C4) had poor linearity for all of the pHs tested (1.6-10.0, R² < 0.95). Hydrophobicity-driven partitioning of methylene blue active substance (MBAS) into chloroform was critical, with long-chain PFAS (e.g., PFOS, PFOA) showing stable absorbance despite that the volume of washing solution increased up to 20 mL. The method was ineffective for SOS and OA, which are non-fluorinated analogs of PFOS and PFOA. The modified MB method developed in this study provides high-quality calibration curves for PFSAs and long-chain PFCAs, with a quantification limit as low as 0.03 mg/L, offering a rapid and cost-effective alternative to HPLC-MS for analysis of some PFAS compounds.

100 项与湖北理工学院相关的药物交易

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100 项与湖北理工学院相关的转化医学

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