A review.The need for novel compounds combined with technol. advances in natural product chem. has nourished the recent renaissance of natural products in drug discovery.The Medicines for Malaria Venture (MMV), in collaboration with BioFocus DPI and the Eskitis Institute for Cell and Mol. Therapies (Eskitis), has established a drug Functional Mols. from Natural Sources discovery program that will enable the identification of small mols. derived from natural sources to become new therapies for fighting malaria.This collaboration is based on key strengths of BioFocus DPI and Eskitis, expertise in natural products drug discovery and anti-malarial HTS.Here we will present BioFocus DPI's approach.