预约演示
更新于：2026-06-15
Shanghai University
更新于：2026-06-15
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肿瘤
神经系统疾病
皮肤和肌肉骨骼疾病
小分子化药
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ITMCTR2025000595
Research on Brain Computer Interface and Traditional Chinese Medicine Multimodal Diagnosis and Treatment Technology for Patients with Mental Depression
ChiCTR2500107536
The effect of morning vs evening exercise training on physical fitness in older adults: A randomized control trial
ChiCTR2400087727
The effects of a randomized, crossover study of functional and plyometric training on volleyball players' performance
100 项与 上海大学 相关的临床结果
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2026-12-31Artificial Cells Nanomedicine and Biotechnology
Novel anti-rheumatic potential of Eucalrobusone C: inhibition of rheumatoid arthritis fibroblast-like synoviocytes and metabolic reprogramming
Article
作者: Luo, Jiewei ; Chen, Jinshui ; Wu, Tianmin ; Chen, Ting ; Zhu, Yaobin ; Feng, Xuebing
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by synovial hyperplasia, inflammatory cell infiltration, and joint destruction. This study investigates the inhibitory effects and metabolic mechanisms of Eucalrobusone C (EC), a novel formyl-phloroglucinol meroterpenoid derivative isolated from Eucalyptus robusta, on Tumour Necrosis Factor-α (TNF-α)-induced rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs). EC was extracted and purified, with purity confirmed using 1H Nuclear Magnetic Resonance Spectrum (NMR) at 400 MHz. RA-FLSs were exposed to varying concentrations of EC, followed by comprehensive assessment including CCK8 assay for cell proliferation, flow cytometry for cell death, and Transwell assay for migration and invasion capacity. Metabolomic profiling employed Ultra-High Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry (UHPLC-Q-TOF MS), integrated with multivariate statistical analysis and bioinformatics tools to identify metabolic alterations. Results indicated that EC suppressed RA-FLS proliferation in a time- and concentration-dependent manner, significantly enhanced apoptosis, and inhibited cell migration and invasion. Metabolomics analysis detected 898 metabolites, with 112 upregulated and 67 downregulated in EC-treated groups compared to TNF-α-induced controls. Key differentially expressed metabolites were enriched in pathways including ABC transporters, neuroactive ligand-receptor interactions, protein digestion and absorption, and cAMP signalling. These findings suggest that EC exerts anti-rheumatic effects by modulating these metabolic pathways, offering potential as a therapeutic agent for RA management.
2026-12-01Nano-Micro Letters
Te-Modulated Fe Single Atom with Synergistic Bidirectional Catalysis for High-Rate and Long–Cycling Lithium-Sulfur Battery
Article
作者: Zhao, Hongbin ; He, Ting ; Wang, Lijun ; Guo, Jian ; Yu, Jia ; Chen, Lu ; Liu, Kangfei
Abstract:
Single-atom catalysts (SACs) have garnered significant attention in lithium-sulfur (Li-S) batteries for their potential to mitigate the severe polysulfide shuttle effect and sluggish redox kinetics. However, the development of highly efficient SACs and a comprehensive understanding of their structure–activity relationships remain enormously challenging. Herein, a novel kind of Fe-based SAC featuring an asymmetric FeN5-TeN4 coordination structure was precisely designed by introducing Te atom adjacent to the Fe active center to enhance the catalytic activity. Theoretical calculations reveal that the neighboring Te atom modulates the local coordination environment of the central Fe site, elevating the d-band center closer to the Fermi level and strengthening the d-p orbital hybridization between the catalyst and sulfur species, thereby immobilizing polysulfides and improving the bidirectional catalysis of Li-S redox. Consequently, the Fe-Te atom pair catalyst endows Li-S batteries with exceptional rate performance, achieving a high specific capacity of 735 mAh g−1 at 5 C, and remarkable cycling stability with a low decay rate of 0.038% per cycle over 1000 cycles at 1 C. This work provides fundamental insights into the electronic structure modulation of SACs and establishes a clear correlation between precisely engineered atomic configurations and their enhanced catalytic performance in Li-S electrochemistry.
2026-12-01Nano-Micro Letters
Efficient Neutral Nitrate-to-Ammonia Electrosynthesis Using Synergistic Ru-Based Nanoalloys on Nitrogen-Doped Carbon
Article
作者: Lisi Huang ; Ozge Hanay ; Jian Zhang ; Liang Wang ; Bingyu Wang ; Jili Yuan ; Baohua Zhang ; Wei Li ; Xin Ge ; Pingzhi Zhang
Abstract:
Electrocatalytic nitrate reduction reaction (NO3RR) represents a sustainable and environmentally benign route for ammonia (NH3) synthesis. However, NO3RR is still limited by the competition from hydrogen evolution reaction (HER) and the high energy barrier in the hydrogenation step of nitrogen-containing intermediates. Here, we report a selective etching strategy to construct RuM nanoalloys (M = Fe, Co, Ni, Cu) uniformly dispersed on porous nitrogen-doped carbon substrates for efficient neutral NH3 electrosynthesis. Density functional theory calculations confirm that the synergic effect between Ru and transition metal M modulates the electronic structure of the alloy, significantly lowering the energy barrier for the conversion of *NO2 to *HNO2. Experimentally, the optimized RuFe-NC catalyst achieves 100% Faraday efficiency with a high yield rate of 0.83 mg h−1 mgcat−1 at a low potential of − 0.1 V vs. RHE, outperforming most reported catalysts. In situ spectroscopic analyses further demonstrate that the RuM-NC effectively promotes the hydrogenation of nitrogen intermediates while inhibiting the formation of hydrogen radicals, thereby reducing HER competition. The RuFe-NC assembled Zn-NO3− battery achieved a high open-circuit voltage and an outstanding power density and capacity, which drive selective NO3− conversion to NH3. This work provides a powerful synergistic design strategy for efficient NH3 electrosynthesis and a general framework for the development of advanced multi-component catalysts for sustainable nitrogen conversion.
100 项与 上海大学 相关的药物交易
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100 项与 上海大学 相关的转化医学
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