Delving into the Latest Updates on Tokuhon Corp. with Synapse

概览

疾病领域	数量

感染	1
免疫系统疾病	1
神经系统疾病	1

排名前五的药物类型	数量

小分子化药	1

排名前五的靶点	数量

COX(环氧化酶)	1

关联

1

项与 Tokuhon Corp. 相关的药物

Flurbiprofen

氟比洛芬

靶点

COX

作用机制

COX抑制剂

在研机构

北京泰德制药股份有限公司 [+7]

原研机构

Kaken Pharmaceutical Co., Ltd.

在研适应症

肌痛 [+16]

非在研适应症

急性咽炎 [+1]

最高研发阶段批准上市

首次获批国家/地区

日本

首次获批日期1979-04-19

4

项与 Tokuhon Corp. 相关的临床试验

JPRN-jRCT2080221798 / Unknown status临床3期

A Long-Term Clinical Study of SFPP in Patients with Osteoarthritis

开始日期2012-05-25

申办/合作机构

Taisho Pharmaceutical Co., Ltd.

[+1]

JPRN-JapicCTI-121840 / Unknown status临床3期

A Long-Term Clinical Study of SFPP in Patients with Osteoarthritis

开始日期2012-05-07

申办/合作机构

Taisho Pharmaceutical Co., Ltd.

[+1]

JPRN-jRCT2080221651 / Unknown status临床3期

Phase3 Study of SFPP in Patients with Osteoarthritis of the knee (Randomized, Parallel Group, Active Comparator-Controlled Study)

开始日期2011-11-11

申办/合作机构

Taisho Pharmaceutical Co., Ltd.

[+1]

100 项与 Tokuhon Corp. 相关的临床结果

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0 项与 Tokuhon Corp. 相关的专利（医药）

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1

项与 Tokuhon Corp. 相关的文献（医药）

2020-02-10·Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)

Study on Adhesive Characteristics of Formulation Modified Esflurbiprofen Mentha Oil Formulation (SFP tape), a Transdermal Analgesic/Anti-inflammatory Tape

作者: Terasaka, Shuichi ; Sato, Junichi ; Endo, Tsuyoshi ; Yamada, Kiyofumi ; Yamaguchi, Jun-ichi ; Kawabata, Shogo ; Konno, Yoshihiro

Esflurbiprofen (SFP) mentha oil formulation (SFP tape) is a tape-type patch containing a non-steroidal anti-inflammatory drug (NSAID) SFP, as the active ingredient.In clin. practice, there is a perception that SFP tape is not always easy to remove from the applied site.In this study, we evaluated the adhesive performance, tack and peel strengths of a for-mulation modified SFP tape prepared with the aim of reducing peel strength to improve the "difficulty of removal" after application.Prior to evaluation, bioequivalence between the modified SFP tape and the com. SFP tape was verified.In vitro drug release-rate and skin permeation profiles of both formulations were shown to be comparable, as were the drug plasma concentration-time profiles in hairless rats after application.Tack and peel strengths were evaluated using the ball tack and Mr peel tests, resp.Our results demonstrated that the formulation modified SFP tape while retaining tack strength (difficult to pull apart on application) reduced peel strength when compared with the com. SFP tape.Furthermore, peel strength was determined to be comparable to representative marketed NSAID tape-type patches.In conclusion, the formulation modified SFP tape with demonstrated bioequivalence to the com. SFP tape showed improved "difficulty of removal" after application while retaining sufficient tack strength.

100 项与 Tokuhon Corp. 相关的药物交易

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100 项与 Tokuhon Corp. 相关的转化医学

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