Objective: To establish the HPLC specific chromatogram of crude drug-decoction pieces-extractives-concentrated granules of Paeoniae Radix Alba and evaluate their correlation. Methods: HPLC method was used. The column was an Agilent HC-C18 column (250 mm×4.6 mm, 5μm); the mobile phase was acetonitrile-0.1% phosphoric acid solution to perform gradient elution; detection wavelength was 280 nm; flow velocity was 1.0 mL/min and column temperature was 30°C. In contrast with the specific chromatogram, the correlation between crude drug-decoction pieces-extractives-concentrated granules was evaluated. Results: The HPLC specific chromatogram of 9 batches of crude drug, decoction pieces, extractives and concentrated granules of Paeoniae Radix Alba showed 6 common peaks. By the correlation comparison, the similarity of specific chromatogram of crude drug and decoction pieces, decoction pieces and extractives, extractives and concentrated granules of Paeoniae Radix Alba were 0.91 to 0.97, exhibiting the good correlation of their chem. components. Overlapping the specific chromatogram of crude drug, decoction pieces, extractives, and concentrated granules of Paeoniae Radix Alba and comparing, the main chromatog. peaks of Paeoniae Radix Alba crude drug also reflected in the chromatogram of decoction pieces, extractives, and concentrated granules. Moreover, the main chromatog. peaks of Paeoniae Radix Alba decoction pieces, extractives, and concentrated granules dated back to the chromatogram of crude drug. The rule of quantity and quality change and transfer in every step of production process could be reflected by applying the specific chromatogram to the whole process monitoring. Conclusion: The HPLC specific chromatogram of crude drug-decoction pieces-extractives-concentrated granules of Paeoniae Radix Alba is established, which reflects the overall appearance of multiple components of crude drug-decoction piecesextractives-concentrated granules of Paeoniae Radix Alba and provides a reference for the quality control of Paeoniae Radix Alba concentrated granules.