Delving into the Latest Updates on Snow Brand Milk Products Co., Ltd. with Synapse

概览

疾病领域	数量

内分泌与代谢疾病	1

排名前五的药物类型	数量

蛋白类药物	1

关联

13

项与 Snow Brand Milk Products Co., Ltd. 相关的药物

Cevimeline Hydrochloride

西维美林

靶点

M3 receptor

作用机制

M3 receptor激动剂

在研机构

KYE Pharmaceuticals, Inc. [+5]

原研机构

Snow Brand Milk Products Co., Ltd.

在研适应症

干燥综合征 [+4]

非在研适应症

阿尔茨海默症 [+4]

最高研发阶段批准上市

首次获批国家/地区

美国

首次获批日期2000-01-11

OSN-001

靶点-

作用机制-

在研机构

Snow Brand Milk Products Co., Ltd. [+1]

原研机构

Snow Brand Milk Products Co., Ltd. [+1]

在研适应症

营养紊乱

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区

日本

首次获批日期1998-07-01

SNA-4606-1

靶点

5α-reductase

作用机制

5α-reductase抑制剂

在研机构-

原研机构

Snow Brand Milk Products Co., Ltd.

在研适应症-

非在研适应症

前列腺增生症

最高研发阶段终止

首次获批国家/地区-

首次获批日期-

1

项与 Snow Brand Milk Products Co., Ltd. 相关的临床试验

JPRN-UMIN000036059 / CompletedN/A

A study for probiotics supplementation effect on lactating women. - A study for probiotics supplementation effect on lactating women.

开始日期2013-05-17

申办/合作机构

Bean Stalk Snow Co. Ltd.

100 项与 Snow Brand Milk Products Co., Ltd. 相关的临床结果

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0 项与 Snow Brand Milk Products Co., Ltd. 相关的专利（医药）

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704

项与 Snow Brand Milk Products Co., Ltd. 相关的文献（医药）

2023-04-01·Nutrients

Comparison of 30 Cytokines in Human Breast Milk between 1989 and 2013 in Japan.

Article

作者: Shimojo, Naoki ; Shiko, Yuki ; Kawasaki, Yohei ; Nakano, Taiji ; Ueno, Hiroshi M. ; Mitsuishi, Chisako ; Yamaide, Fumiya ; Takahashi, Tomoki

Milk cytokines play a vital role in mucosal immunity during infancy by supporting immune development and functions. Although the maternal background characteristics influence milk cytokines, changes in cytokine levels across generations remain unclear. Colostrum (C, n = 48) and mature milk (MM, n = 49) samples were collected from lactating Japanese women in 1989 (2727 samples) and 2013 (1408 samples). Milk cytokines were comprehensively measured using a suspension array and immunosorbent assays. The positive rates and cytokine concentrations were compared between the two generations using logistic and multiple regression analyses. Twenty-eight cytokines tested positive in all sample groups (1989-C, 1989-MM, 2013-C, and 2013-MM). The median osteopontin (OPN) level was significantly higher in the 1989-C group than in the 2013-C group (318.1 vs. 137.5 μg/mL; p = 0.0016) but did not differ between the MM groups. The median TGF-β1 level was significantly lower in the 1989-MM group than in the 2013-MM group (1056.2 vs. 1330.8 pg/mL; p = 0.008) but did not differ between the C groups. Most cytokines were comparable between generations, except for potential variation in the C-OPN and TGF-β1 levels. Milk cytokine secretion may reflect temporal changes in maternal background characteristics; however, the results from the analysis of 30-year-old samples may have influenced the milk cytokine levels. Further studies are needed with a larger number of milk samples collected from the same individuals at multiple time points over a wide lactation period, with detailed data on the maternal and infant background characteristics and diets.

2023-03-01·Vaccines

Enhancement of Vaccine-Induced T-Cell Responses by PD-L1 Blockade in Calves.

Article

作者: Sajiki, Yamato ; Kato, Yukinari ; Nakamura, Hayato ; Konnai, Satoru ; Maekawa, Naoya ; Suzuki, Yasuhiko ; Noda, Haruka ; Watari, Kei ; Murata, Shiro ; Okagawa, Tomohiro ; Honma, Mitsuru ; Ohashi, Kazuhiko ; Ganbaatar, Otgontuya

Interactions between programmed death 1 (PD-1) and PD-ligand 1 (PD-L1) cause functional exhaustion of T cells by inducing inhibitory signals, thereby attenuating effector functions of T cells. We have developed an anti-bovine PD-L1 blocking antibody (Ab) and have demonstrated that blockade of the interaction between PD-1 and PD-L1 reactivates T-cell responses in cattle. In the present study, we examined the potential utility of PD-1/PD-L1-targeted immunotherapy in enhancing T-cell responses to vaccination. Calves were inoculated with a hexavalent live-attenuated viral vaccine against bovine respiratory infections in combination with treatment with an anti-PD-L1 Ab. The expression kinetics of PD-1 in T cells and T-cell responses to viral antigens were measured before and after vaccination to evaluate the adjuvant effect of anti-PD-L1 Ab. PD-1 expression was upregulated in vaccinated calves after the administration of a booster vaccination. The activation status of CD4⁺, CD8⁺, and γδTCR⁺ T cells was enhanced by the combination of vaccination and PD-L1 blockade. In addition, IFN-γ responses to viral antigens were increased following combinatorial vaccination with PD-L1 blockade. In conclusion, the blockade of the PD-1/PD-L1 interaction enhances T-cell responses induced by vaccination in cattle, indicating the potential utility of anti-PD-L1 Ab in improving the efficacy of current vaccination programs.

2023-02-25·Nihon Chikusan Gakkaiho

A case where woody roughage made from Japanese white birch had an effect on the fattening of Japanese Black

作者: KOBAYASHI, Yusuke ; HIYAMA, Ryo ; KUCHIDA, Keigo ; HONMA, Mitsuru ; ABE, Kentaro ; SEKI, Kazuto ; NAKAI, Shintaro ; KOMATA, Hirotaka ; ORIHASHI, Ken

100 项与 Snow Brand Milk Products Co., Ltd. 相关的药物交易

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100 项与 Snow Brand Milk Products Co., Ltd. 相关的转化医学

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2024年11月05日管线快照

管线布局中药物为当前组织机构及其子机构作为药物机构进行统计，早期临床1期并入临床1期，临床1/2期并入临床2期，临床2/3期并入临床3期

批准上市

1

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当前项目

药物(靶点)	适应症	全球最高研发状态

OSN-001	营养紊乱更多	批准上市
西维美林 ( M3 receptor )	痴呆更多	终止
NKS-01 ( aromatase )	乳腺癌更多	终止
SN-198C	肿瘤更多	终止
SN-198D ( Bacterial outer membrane proteins )	肿瘤更多	终止