Core-shell structured nickel@polydopamine magnetic composite nanotubes for chelator-free protein removal: Self-released Ni2+-mediated selective adsorption of histidine-rich proteins

Article

作者: Li, Xiangzi ; Wang, Jinzhao ; Dai, Jiwei ; Hu, Chengming ; Fu, Mengxian ; Cheng, Xiaomei ; Liu, Chang ; Wang, Meifang ; Lin, Xiangsong

Construction of magnetic nanotubes and transition metal ion generated by acid etching from its own surface (defined as "self-released" systems) can effectively address the issues of complex operation and poor adsorption performance associated with traditional immobilized metal affinity chromatography (IMAC) materials. Based on the magnetic Ni core and polydopamine (PDA) shell, a core-shell structured Ni@PDA magnetic composite nanotubes and their acid-etched product (defined as Ni@PDA-T) were developed and synergistically provided excellent magnetic responsiveness, low cell toxicity and more active sites, enabling efficient magnetic separation and surface Ni²⁺ self-release. Surface self-released Ni²⁺ enabled coordinate capture of histidine-rich proteins without requiring exogenous metal ion supplementation after fixed onto PDA with pH 8.0, simplifying operation and enhancing adsorption efficiency. Given the differences in histidine content among Bovine hemoglobin (BHb), Bovine serum albumin (BSA), and Lysozyme (LYZ), Ni@PDA-T exhibited a maximum adsorption capacity of 4556 mg g^-1 for BHb, which is rich in histidine residues. Density functional theory (DFT) calculations indicate that p-d orbital coordination interactions dominate the Histidine (His) protein's immobilization onto the Ni site and result in superior adsorption behavior for the His protein by DOPAm-Ni²⁺ functional group. SDS-PAGE analysis of mixed protein systems and actual bovine blood samples further confirmed the selective adsorption of BHb by Ni@PDA-T. Chelator-free blood purification was achieved through synergistic coordination between self-released Ni²⁺ and histidine residues, overcoming the reliance on traditional chelating agents.

2026-04-01·PSYCHIATRY RESEARCH-NEUROIMAGING

Neural evidence for the influence of cognitive control by facial emotion under varying task difficulty in individuals with borderline personality disorder traits

Article

作者: Wang, Lijun ; Zheng, Man ; Peng, Suhao ; Yang, Si

Borderline personality disorder traits (BPD traits) represent subclinical characteristics associated with borderline personality disorder (BPD), which are marked by impaired cognitive control of emotion processing. Although the cognitive control deficit of negative emotions is a core feature of BPD, the characteristics and neural basis of this deficit in non-clinical BPD traits individuals remain unclear. The present study employed a novel facial majority function task (fMFT) combined with event-related potential (ERP) recording to explore the cognitive control of negative facial emotion under varying task difficulty in individuals with high BPD traits. We recruited 50 high BPD traits participants and 50 low BPD traits participants for the fMFT. The behavioral results showed that under low and medium task difficulty conditions, there were no significant differences in reaction time and accuracy between the two groups. However, under negative emotion-high task difficulty conditions, the reaction time of the high BPD traits group was significantly longer than that of the low BPD traits group, and the accuracy was significantly lower than that of the low BPD traits group. The ERP results showed that high BPD traits group exhibited reduced frontal N200 amplitudes and increased parietal P300 amplitudes compared to the low BPD traits group. Furthermore, both groups exhibited decreased LPP amplitudes with increasing task difficulty in positive emotion conditions, but this task difficulty effect was not significant in negative emotion conditions in the high BPD traits group. These findings demonstrate that BPD traits leads to selective deficits in cognitive control of emotion processing, and negative emotion leads to their impairment in the processing of conflict monitoring and inhibition with task difficulty increasing.

2026-03-01·ENVIRONMENTAL RESEARCH

Stage-specific FeS-mediated regulation of Paracoccus denitrificans during carbon consumption by machine learning-assisted comparative proteomics

Article

作者: Zha, Yunyi ; Ye, Ping ; Huang, Xuan ; Gao, Linjun ; Zhang, Yongzhi ; Wan, Rui ; Wang, Wenyu

Inorganic electron donors improve low C/N wastewater denitrification performance and management. This study used an integrated strategy combining proteomics, machine learning, and electron transfer system characterization to elucidate FeS's regulatory mechanisms on microbial denitrification during carbon source depletion. Monitoring results revealed significant differences in denitrification performance between two experimental groups (designated as CK and FD) during both carbon-available (Stage 1) and carbon-depleted (Stage 2) phases. Overall, the denitrification indicators (NO₃^--N, NO₂^--N, and TN) of the FD group significantly outperformed those of the CK group in Stage 2. The electron transport system activity (ETSA) in the FD group was consistently higher than that in the CK group. Electrochemical analysis further demonstrated higher electron exchange efficiency of microorganisms in the FD system. Morphology and elemental analysis indicated bacterial surface transformation in FD samples, characterized by significant membrane distortion and attachment of nanoparticles (NPs). Proteomics-driven random forest (RF) modeling identified stage-specific regulatory patterns of FeS, demonstrating distinct mechanistic signatures among differentially up-regulated proteins. Briefly, in Stage 1, bacteria mobilized proteins TenA and GtsB to efficiently utilize glucose, and fully exploiting periplasmic electrons through CYC, NapA, and NosD. In Stage 2, metabolic activities shifted toward conservation. Bacteria upregulated PhaZ to utilize limited endogenous carbon sources, captured more electron donors via the Fe²⁺ channel opened by OmpU, and mobilized UbiH and NarG to optimize transmembrane electron transfer. These findings are pivotal for developing inorganic electron donor regulation strategies to maintain stable system performance in low C/N wastewater treatment processes.

项与安徽师范大学相关的新闻（医药）

2025-03-19

·生物世界

Frontiers 近期专刊征稿汇总：Frontiers in Immunology

前沿专刊「Research Topic」，是 Frontiers 赋能学术工作者的创新方式之一，前沿专刊的客座主编确定某领域内的研究方向，接收相关领域作者的投稿，最终以文章合辑的形式发表在期刊正刊。我们将定期整理近期在征稿中的前沿专刊，以下为 Frontiers in Immunology (IF: 5.7 | CiteScore: 9.8) 正在接受投稿的专刊精选。 Frontiers in Immunology 是国际免疫学会联合会（IUIS）的官方期刊，发表经过严格同行评审的基础、转化和临床免疫学等方面的研究，涵盖整个免疫学领域。神经退行性、神经遗传和神经代谢性疾病的免疫机制新见解 Emerging Insights into Immunological Mechanisms in Neurodegenerative, Neurogenetic, and Neurometabolic Diseases 客座编委团队：崔彩莲教授 – 北京大学张浩林教授 – 北京工业大学王娟教授 – 北京工业大学 Adelaide Fernandes 教授 – University of Lisbon 征稿截止时间：2025 年 6 月 9 日 ↑ 扫描二维码查看专刊 ↑ 原文链接👇 https://www.frontiersin.org.cn/research-topics/68035/ 结直肠癌的免疫疗法与机制 Colorectal Cancer Immunotherapy and Immune Mechanisms 客座编委团队： Herrmann, Martin, Professor - University Hospital Erlangen 孙玉琳副研究员 - 中国医学科学院肿瘤医院分子肿瘤学国家重点实验室郑朝旭教授 - 国家癌症中心中国医学科学院肿瘤医院刘正教授 - 中国医学科学院肿瘤医院征稿截止时间：2025 年 6 月 27 日 ↑ 扫描二维码查看专刊 ↑ 原文链接👇 https://www.frontiersin.org.cn/research-topics/68309/ 疾病进展中的免疫遗传动态与治疗策略 Immune-genetic dynamics in disease progression and therapeutic strategies 客座编委团队：周忠宝住院医师 - 首都医科大学附属北京天坛医院张勇主任医师 - 首都医科大学附属北京天坛医院 Qi Zhang 研究员 - Yale school of medicine 征稿截止时间：2025 年 7 月 4 日 ↑ 扫描二维码查看专刊 ↑ 原文链接👇 https://www.frontiersin.org.cn/research-topics/68350/ 炎症在自身免疫性疾病中的致病机制和治疗专题系列：第三卷 Community Series in Pathogenetic mechanism and therapeutic target for inflammation in autoimmune disease: Volume Ⅲ 客座编委团队：高建教授 - 上海交通大学医学院附属上海儿童医学中心吕良敬教授 - 上海交通大学医学院附属仁济医院 Jing Tian, Senior Research Fellow- University of Tasmania 梁敏锐高级研究员 - 复旦大学附属华山医院许岳慷教授 - 安徽师范大学潘海峰教授 - 安徽医科大学征稿截止时间：2025 年 8 月 8 日 ↑ 扫描二维码查看专刊 ↑ 原文链接👇 https://www.frontiersin.org.cn/research-topics/69534/ 多尺度与多组学融合推动免疫介导性疾病精准医疗 Multi-Scale and Multi-Omics Fusion Enables Precision Medicine for Immune-Mediated Disorders 客座编委团队：程立新教授 - 深圳市人民医院戚丽霜教授 - 哈尔滨医科大学 Jing Gao 高级研究 - Karolinska Institutet 郑旭彬助理教授 - 大湾区大学征稿截止时间：2025 年 6 月 8 日 ↑ 扫描二维码查看专刊 ↑ 原文链接👇 https://www.frontiersin.org.cn/research-topics/68497/ 解密宿主-病毒相互作用并推进治疗学 Deciphering Host-Virus Interactions and Advancing Therapeutics 客座编委团队：卢洪洲教授 - 复旦大学 Jean-Pierre Routy, Professor - McGill University 李倩研究员 - 深圳第三人民医院征稿截止时间：2025 年 5 月 30 日 ↑ 扫描二维码查看专刊 ↑ 原文链接👇 https://www.frontiersin.org.cn/research-topics/66670/ ncRNAs 在癌症免疫原性细胞死亡中的作用 Role of ncRNAs in Immunogenic Cell Death of Cancer 客座编委团队：彭芙副研究员 - 四川大学华西药学院王志宇副院长/教授 - 广东省中医院乳腺病专科医院/广州中医药大学王能研究员 - 广州中医药大学祝旭东研究员 - 肯塔基大學征稿截止时间：2025 年 4 月 25 日 ↑ 扫描二维码查看专刊 ↑ 原文链接👇 https://www.frontiersin.org.cn/research-topics/65676/ 生物活性化合物和营养素在肠粘膜免疫、肝脏和血管炎症中的作用 The Role of Bioactive Compounds and Nutrients in Intestinal Mucosal Immunity, Liver and Vascular Inflammation 客座编委团队：阮征教授 - 南昌大学 Fengjie Sun, Professor - Georgia Gwinnett College Tarek Abedelmaksoud, Professor - Cairo University 征稿截止时间：2025 年 8 月 9 日 ↑ 扫描二维码查看专刊 ↑ 原文链接👇 https://www.frontiersin.org.cn/research-topics/69554/ 点击查看 Frontiers 前沿专刊案例：樊嘉院士/周俭教授主持前沿专刊 — 中国肝癌治疗的概况与展望仝小林院士领衔前沿专刊 — 中医药与肠道微生物的相互作用黄荷凤院士领衔前沿专刊 — 多囊卵巢综合征的机制和临床管理王松灵院士领衔前沿专刊 — 免疫信号在干细胞治疗中的作用赵继宗院士领衔前沿专刊 — 脑血管疾病的精准治疗 Frontiers 总部位于瑞士，是全球领先的开放获取（Open Access）出版商，致力于使科学在全球范围内更加开放。欲了解更多详情，欢迎访问 Frontiers 官方网站：www.frontiersin.org. 将我们设为星标，成为全球开放科学的推动者！您点“在看”的一小步，开放科学的一大步 ↓↓

免疫疗法

2024-11-25

·药精通Bio

【今日大咖】深圳市第三人民医院党委副书记、院长卢洪洲教授邀您出席检测自动化智慧化论坛

IND2025重磅来袭论坛名称：IND2025感染疾病诊断技术及检测自动化建设论坛举办时间：2025年2月20-21日举办地点：苏州主办单位：上海傲顺商务咨询有限公司、药精通Bio 联合主办：中国医疗器械行业协会体外诊断（IVD）分会支持单位：金域医学集团研讨主题：检测自动化建设、NGS自动化、自动建库、制备一体化、AI与NGS、mNGS、tNGS、纳米孔测序、多重PCR等；展位联系人：李欣欣 177 0186 0390 IND2025论坛限量免费参会入场券扫码领取 IND2025组委会有幸邀请到深圳市第三人民医院党委副书记、院长；美国微生物科学院院士卢洪洲教授出席并授课： 1996年安徽师范大学生物系本科，2001年北京大学生命科学学院博士，国家基金委生命学部免疫学杰青，二级研究员、余㵑学者、上海交大特聘教授、上海市领军人才。现任上海交大医学院上海市免疫学研究所科研副所长、上海市欧美同学会副会长&生物医药分会会长、European Journal of Immunology 执行副主编等。卢洪洲，主任医师、二级教授、内科学博士、留美博士后；内科学博士生导师、护理学博士生导师、公共卫生管理博士生导师、公共卫生法律硕士生导师；博士后流动站站长。入选教育部长江学者、国家百千万人才工程、享受国务院特殊津贴、“有突出贡献中青年专家”。深圳市国家级领军人才、首届深圳市疫情防控公共卫生专家组组长。在国内外发表各类论文448篇，其中在SCI引用杂志包括《Nature》、《Cell Discovery》、《New England Journal of Medicine》发表论著189篇；主编专业参考书12部。已获国家科学技术特等奖、法国国家医学科学院“夏▪杜奖”；以第一完成人获得上海科技成果一等奖、上海科技成果二等奖、上海医学科技一等奖等10余项科技成果奖；获专利5项。 01 IND2025嘉宾总图 02 IND2025往届精彩瞬间 03 IND2025往届会后报告 04 IND2025合作热线 IND2025论坛开放主题演讲、产品展示、晚宴冠名、论坛支持方、名卡吊绳冠名、企业参观等多种宣传形式，为您全方位的展示创新诊断技术上中下游解决方案提供定制化服务；名额有限，招商热线：李欣欣177 0186 0390（同微信）； 05 IND2025报名方式 ① 免费参会入场券获取方式：转发本文到朋友圈后集赞18个，截图给小编，小编微信二维码如下； ② 早鸟票需费用699元/人，截止1月27日；包含会议入场券、午餐券、茶歇、会议资料； ③ 标准票需费用999元/人，截止2月20日；包含会议入场券、午餐券、茶歇、会议资料；

临床申请

2023-06-08

·Science Daily

'Hot Jupiters' may not be orbiting alone

Astronomers challenge longstanding beliefs about the isolation of 'hot Jupiters' and proposes a new mechanism for understanding the exoplanets' evolution. Research led by an Indiana University astronomer challenges longstanding beliefs about the isolation of "hot Jupiters" and proposes a new mechanism for understanding the exoplanets' evolution. While our Jupiter is far away from the sun, hot Jupiters are gas giant planets that closely orbit stars outside our solar system for an orbital period of less than 10 days. Previous studies suggested they rarely have any nearby companion planets, leading scientists to believe that hot Jupiters formed and evolved through a violent process that expelled other planets from the area as they moved closer to their host stars. The research team's findings reveal that hot Jupiters do not always orbit alone. "Our research shows that at least a fraction of hot Jupiters cannot form through a violent process," said Songhu Wang, assistant professor of astronomy in the College of Arts and Sciences. "This is a significant contribution to advance our understanding of hot Jupiter formation, which can help us learn more about our own solar system." Wang presented the results of the research at the June 2023 meeting of the American Astronomical Society in Albuquerque, New Mexico. Researchers analyzed the full, four-year data set for hot and warm Jupiters from NASA's Kepler Mission. Warm Jupiters have a longer orbital period that ranges from 10 to 300 days. Researchers used transit timing variations to determine that at least 12% of hot Jupiters and 70% of warm Jupiters have a nearby planetary companion orbiting their host stars. Wang and his collaborators combined their results with existing observational constraints to propose a new framework for explaining the evolution of hot and warm Jupiters and why some have companion planets. They determined that the makeup of hot and warm Jupiter systems depends on the occurrence of gas giants in the system, which impacts how much the planets interact and migrate. The findings provide a launching point into future research about exoplanets and our solar system's planets. "The ultimate goal for astronomers is to set our solar system into the bigger picture -- 'Are we unique?'" Wang said. "This helps us to understand why we don't have a hot Jupiter in our solar system." Additional collaborators are Dong-Hong Wu, lecturer in the Department of Physics at Anhui Normal University, and Malena Rice, 51 Pegasi b Fellow at the Massachusetts Institute of Technology and incoming professor at Yale University. Wang has long been interested in the configurations and demographics of exoplanets. He uses observational research to try to understand their dynamics and origins, helping astronomers better understand how our solar system fits into a larger cosmic context.

100 项与安徽师范大学相关的药物交易

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100 项与安徽师范大学相关的转化医学

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管线布局中药物为当前组织机构及其子机构作为药物机构进行统计，早期临床1期并入临床1期，临床1/2期并入临床2期，临床2/3期并入临床3期

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药物(靶点)	适应症	全球最高研发状态

Bletilla striata polysaccharides ( Akt x PI3Ks )	衰老更多	临床前
CyB	糖尿病更多	临床前
LD-VP1	动脉粥样硬化更多	临床前
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