Delving into the Latest Updates on Astra Arcus AB with Synapse

概览

疾病领域	数量

神经系统疾病	1

排名前五的药物类型	数量

小分子化药	1

排名前五的靶点	数量

nNOS(脑型一氧化氮合酶)	1

关联

10

项与 Astra Arcus AB 相关的药物

ARR-17477

靶点

nNOS

作用机制

nNOS抑制剂

在研机构

Oakland University [+2]

原研机构

AstraZeneca R&D Charnwood [+1]

在研适应症

大脑中动脉梗塞

非在研适应症

肌萎缩侧索硬化 [+1]

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

NAS-181

靶点

5-HT1B receptor

作用机制

5-HT1B receptor拮抗剂

在研机构-

原研机构

Astra Arcus AB

在研适应症-

非在研适应症

重度抑郁症

最高研发阶段终止

首次获批国家/地区-

首次获批日期-

ARR-17779

靶点

CHRNA7

作用机制

α7 receptor激动剂

在研机构-

原研机构

Astra Arcus AB

在研适应症-

非在研适应症

焦虑症 [+1]

最高研发阶段终止

首次获批国家/地区-

首次获批日期-

100 项与 Astra Arcus AB 相关的临床结果

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0 项与 Astra Arcus AB 相关的专利（医药）

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33

项与 Astra Arcus AB 相关的文献（医药）

1998-09-01·Behavioural Pharmacology4区 · 心理学

The discriminative stimulus effects of clomethiazole in the rat

4区 · 心理学

Article

作者: Ensler, K. ; Evenden, J. ; Jackson, D. M. ; Stephan-Dahlin, C.

Rats were trained in a two-lever drug discrimination procedure using saline or clomethiazole (8 mg/kg, s.c. 15 min) as the training stimuli. A criterion of 9/10 days correct lever choice was adopted to select rats for substitution tests. The clomethiazole (CMZ) cue was not especially strong, and stable performance at this level was not achieved consistently. Nevertheless, in a series of substitution tests carried out in extinction, diazepam (3 mg/kg), chlordiazepoxide (10 mg/kg), phenobarbital (60 mg/kg), dizocilpine (0.1 mg/kg) and mianserin (3.0 mg/kg) were found to substitute for the training dose of CMZ. The first two of these produced a percentage choice of the drug lever equal to that produced by the training dose of CMZ (full generalization) whereas the latter three produced only partial generalization. Ethanol, muscimol, allopregnanolone, chlorpromazine and amitriptyline did not generalize to CMZ. CMZ is known to potentiate gamma-aminobutyric acid (GABAA) receptor function, a finding supported by the generalization to CMZ of the two benzodiazepines and phenobarbital. However, not all drugs acting at GABAA receptors generalized to CMZ. Although CMZ has no affinity for the N-methyl-D-aspartate (NMDA) receptor, it antagonizes a number of pharmacological responses mediated by NMDA receptors. The generalization in the drug discrimination procedure reported here support the suggestion that altering GABA activity can modulate NMDA-mediated responses. The lack of generalization after treatment with ethanol, chlorpromazine and amitriptyline suggests that the interoceptive cues are not mediated by a generalized sedation or drug-induced motor impairment.

1997-10-01·Behavioural Pharmacology4区 · 心理学

The effect of dizocilpine (MK-801) on conditional discrimination learning in the rat

4区 · 心理学

Article

作者: Ridley, R. M. ; Murray, T. K.

The effect of the non-competitive N-methyl-D-aspartate (NMDA)-receptor antagonist, dizocilpine (MK-801) on the acquisition and reversal of conditional tasks was investigated using a Y-maze. Dizocilpine-treated rats were severely impaired on acquisition of a visuo-spatial task and were unable to learn the reversal of this task. 'Worse than chance' performance by dizocilpine-treated (and saline-treated) rats at the beginning of reversal testing, which was given 24 h after achieving criterion on acquisition, indicated that dizocilpine-treated animals simultaneously exhibited good memory but impaired learning for the type of information required for this task. Dizocilpine-treated rats were unable to acquire a visuo-visual conditional discrimination and therefore could not be assessed on reversal of this task. These very substantial impairments were larger than those found in comparable experiments using non-conditional tasks.

1997-09-01·NeuroReport4区 · 医学

Dopamine D2 receptor upregulation in rat neostriatum following in vivo infusion of forskolin

4区 · 医学

Article

作者: Wanderoy, Maria H. ; Ahlenius, Sven ; Westlind-Danielsson, Anita

Intracerebroventricular (i.c.v.) forskolin infusion for 5 days resulted in a concentration-dependent increase in rat striatal dopamine (DA) D2 receptors measured with [3H]raclopride. In animals given 50 nmol/h forskolin, the highest concentration used, raclopride-mediated suppression of spontaneous locomotor activity was attenuated, and (+/-)-7-hydroxy-dipropyl-aminotetralin HBr (7-OH-DPAT)-mediated inhibition of striatal DA synthesis, as estimated by the accumulation of DOPA following inhibition of cerebral decarboxylase, was enhanced. These data suggest that the DA D2 receptor increase comprises receptors localized both post- and presynaptically. The density of striatal DA D1 receptors was also changed with the forskolin treatment, in a concentration-dependent fashion, but in the opposite direction to DA D2 receptors. These findings suggest that striatal DA receptor sensitivity can be changed by manipulation at the second messenger level (e.g. independent of direct neurotransmitter-receptor interactions) in vivo.

100 项与 Astra Arcus AB 相关的药物交易

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100 项与 Astra Arcus AB 相关的转化医学

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临床前

1

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其他

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当前项目

药物(靶点)	适应症	全球最高研发状态

ARR-17477 ( nNOS )	大脑中动脉梗塞更多	临床前
QX-222 ( Sodium channels )	心律失常更多	终止
ARR-15849 ( CCKA )	肥胖更多	终止
ARR-17779 ( CHRNA7 )	认知障碍更多	终止
NAS-181 ( 5-HT1B receptor )	重度抑郁症更多	终止