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更新于：2025-12-11
Shaoxing People's Hospital
更新于：2025-12-11
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肿瘤
皮肤和肌肉骨骼疾病
内分泌与代谢疾病
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NCT07203248
A Real-world Study on the Use of CGRP-targeted Medications for the Treatment of Vestibular Migraine in Chinese Patients
ChiCTR2500112019
Efficacy and safety of sequential therapy with Venetoclax, Azacitidine, and Homoharringtonine in elderly patients with de novo AML: A prospective, single-arm, multicenter, exploratory clinical trial
ChiCTR2500109643
A real-world study of anlotinib hydrochloride combined with third-generation EGFR-TKIs in the treatment of locally advanced / advanced non-small cell lung cancer with slow progression of EGFR-TKIs.
100 项与 绍兴市人民医院 相关的临床结果
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2026-02-01TISSUE & CELL
Ginsenoside Rg3 alleviates allergic rhinitis by regulating NLRP3-mediated inflammatory response and pyroptosis through SIRT6
Article
作者: Wang, Fang ; Wang, Wei
BACKGROUND:
Allergic rhinitis (AR) is positively correlated with pyroptosis induced by NLR family pyrin domain containing 3 (NLRP3). Here, the effect of ginsenoside Rg3 on pyroptosis in the progression of AR was evaluated.
METHODS:
Human nasal epithelial cells (HNEPCs) were exposed to house dust mite (HDM) allergen to establish an AR cell model. Cell viability and pyroptosis were tested utilizing CCK-8 and flow cytometry. RT-qPCR and Western blot were used to detect mRNA and protein expression. Co-immunoprecipitation (Co-IP) assay was adopted to validate the molecular interaction. IgE, IL-4, IL-5, IL-13, IL-1β and IL-18 were detected by ELISA. AR mouse model was established using OVA and aluminum hydroxide. The sneezing frequency and nose rubbing frequency of mice were evaluated. HE staining was used to evaluate the pathological changes of nasal mucosa. Pyroptosis was detected by TUNEL and GSDMD staining.
RESULTS:
Ginsenoside Rg3 blocked NLRP3 inflammasome activation and pyroptosis induced by HDM allergen in HNEPCs, and increased cell activity inhibited by HDM. SIRT6 depletion overturned the suppressive effect of ginsenoside Rg3 on HDM-caused inflammation and pyroptosis in HNEPCs. Blocking SIRT6 diminished ginsenoside Rg3's protective role against sneezing and rubbing nose, inflammation and pyroptosis in AR mice. Furthermore, Co-IP assay confirmed that SIRT6 interacted with NLRP3 protein in HNEPCs. SIRT6 overexpression could decrease NLRP3 acetylation level and reduce NLRP3 expression.
CONCLUSION:
Our results reveal that ginsenoside Rg3 mitigates AR by controlling NLRP3-triggered inflammatory response and pyroptosis via SIRT6, which provides a new therapeutic strategy for AR treatment.
2026-02-01NEUROPHARMACOLOGY
Olfactory ensheathing cells reduce trigeminal neuralgia pain and anxiety by suppressing P2X7R-mediated A1 Astrocyte activation in mice
Article
作者: Li, Zhiwei ; Li, Mengyun ; Lin, Hui ; Xu, Lili ; He, Lingyan ; Shan, Yue ; Lu, Jiafeng ; Shao, Xian ; Chen, Zhonghua
Trigeminal neuralgia (TN), the most intense chronic pain syndrome affecting the craniofacial region, is closely associated with neuroinflammation and aberrant glial-neuron interactions. Our preliminary studies demonstrated that implantation of exogenous olfactory ensheathing cells (OECs) alleviates TN, suppresses P2X7 receptor (P2X7R) expression in neural tissues, and ameliorates neuroinflammatory responses. However, specific mechanisms underlying these effects remain unclear. This is the first study to investigate whether exogenous OECs transplantation alleviates TN-induced pain and anxiety symptoms by inhibiting P2X7R to suppress the activation of A1 astrocytes. In vitro, astrocytes were modeled using the C8D1A cell line. OEC-conditioned medium suppressed lipopolysaccharide-induced astrocyte activation and downregulated the expression of A1 astrocyte markers by inhibiting P2X7R activation. In vivo, a TN model was established in C57BL/6 mice (regardless of gender) via distal ligation of the infraorbital nerve. An adeno-associated virus (AAV) carrying an astrocyte-specific promoter was used to selectively silence P2X7R in astrocytes of the right medial habenula (MHb). Both OECs transplantation and P2X7R-AAV partially reduced the expression of A1 reactive astrocyte markers in the MHb and partially alleviated pain and anxiety-like behaviors in mice. Meanwhile, the combination of OECs transplantation and P2X7R-AAV treatment significantly ameliorated pain and anxiety symptoms in TN mice. This study demonstrates that OECs may alleviate pain and anxiety in TN mice by targeting P2X7R to inhibit A1 reactive astrocyte activation and modulate astrocyte reactivity in the MHb. By combining in vitro and in vivo approaches, this study provides experimental evidence to support a combined cellular-molecular therapeutic strategy for TN.
2026-01-01COLLOIDS AND SURFACES B-BIOINTERFACES
An antibacterial dual-network polyelectrolyte coating for orthopedic implant
Article
作者: Zhang, Kai-Long ; Che, Bin ; Zhou, Ping ; Jiang, Chao ; Zhang, Ding-Yi ; Pan, Xin ; Wang, Fei ; Ren, Ke-Feng ; Wang, Teng-Jie
Bacterial infections, aseptic loosening, and poor osseointegration remain challenges for orthopedic implants. In this study, we developed a dual-network polyelectrolyte antibacterial coating for orthopedic implants to prevent bacterial infections. The coating was prepared via UV-triggered in situ polymerization, composed of polyethyleneimine (PEI) and polyacrylic acid (PAA), with enhanced mechanical properties due to electrostatic interactions between them. The antimicrobial peptide ε-poly-L-lysine (EPL) was immobilized in the coating, providing efficient antibacterial functionality. The coating's substrate was made of hydroxyapatite (HA) and polylactic acid (PLA) composites to promote bone cell growth and tissue regeneration. In vitro experimental results demonstrated that the coating exhibited excellent antibacterial properties against both Gram-negative and Gram-positive bacteria, while enhancing the adhesion, proliferation, and differentiation of osteoblasts. In vivo experiments further confirmed the coating's capability to resist infection in an infected microenvironment. This study provides a practical strategy for developing orthopedic implant surface coatings with antibacterial functions.
100 项与 绍兴市人民医院 相关的药物交易
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