主要研究目的：以赖诺普利氢氯噻嗪片（商品名：ZESTORETIC®）为参比制剂，以江苏天士力帝益药业有限公司生产的赖诺普利氢氯噻嗪片为受试制剂，通过单中心、随机、开放、单剂量空腹/餐后口服给药的临床研究，评价受试制剂和参比制剂在空腹/餐后状态下的生物等效性。次要研究目的：观察赖诺普利氢氯噻嗪在中国健康人群的安全性。

开始日期2020-07-13

申办/合作机构

江苏天士力帝益药业有限公司

NCT01827878 / Completed临床1期

A Randomized, Open Label, Balanced, Two-Treatment, Two-Period, Two-Sequence, Single Dose, Crossover, Comparative Bioavailability Study of Lisinopril and Hydrochlorothiazide Tablets (20+25) mg of M/s Ipca Laboratories Ltd., India With Zestoretic® 20/25 Lisinopril/Hydrochlorothiazide Tablets of M/s AstraZeneca Pharmaceuticals LP, USA in Normal, Healthy, Adult, Human Subjects Under Fed Condition.

This is a randomized, open Label, balanced, two-treatment, two-period, two-sequence, single dose, cross over pivotal study. The purpose of this study is to assess the bioequivalence between Test Product and the corresponding Reference Product under fed condition in normal, healthy, adult, human subjects.

开始日期2012-10-01

申办/合作机构

Ipca Laboratories Ltd.

NCT01831700 / Completed临床1期

This is a randomized, open Label, balanced, two-treatment, two-period, two-sequence, single dose, cross over pivotal study. The purpose of this study is to assess the bioequivalence between Test Product and the corresponding Reference Product under fasting condition in normal, healthy, adult, human subjects.

开始日期2012-10-01

申办/合作机构

Ipca Laboratories Ltd.

100 项与 ACE x NCC x ACE2 相关的临床结果

登录后查看更多信息

100 项与 ACE x NCC x ACE2 相关的转化医学

登录后查看更多信息

0 项与 ACE x NCC x ACE2 相关的专利（医药）

登录后查看更多信息

项与 ACE x NCC x ACE2 相关的文献（医药）

2019-10-01·Hypertension Research3区 · 医学

Azilsartan causes natriuresis due to its sympatholytic action in kidney disease

3区 · 医学

Article

作者: Takahashi, Yasuhito ; Yokoo, Takashi ; Yarita, Miki ; Hayashi-Ishikawa, Naomi ; Sugano, Naoki ; Tokudome, Goro ; Takane, Koki ; Morisawa, Norihiko ; Kidoguchi, Satoshi

The sympathoinhibitory mechanism of azilsartan was investigated in an adenine-induced chronic renal failure model. Azilsartan exerted an antihypertensive effect, though BP elevation induced by adenine was marginal. The creatinine value was significantly lower in the azilsartan group (AZ) than in the vehicle group (VEH); furthermore, proteinuria was suppressed, and sodium excretion was augmented in the AZ group. The low frequency (LF) of systolic BP was suppressed (VEH: 4.07 ± 2.67 mmHg² vs. AZ: 3.32 ± 1.93 mmHg² P < 0.001), and the spontaneous baroreflex gain (sBRG) was augmented (VEH: 1.04 ± 0.62ms/mmHg vs. AZ: 1.38 ± 0.69 ms/mmHg, P < 0.001) in AZ. There were no significant differences in ACE1 and ACE2 expression between the groups, which indicated that the action of azilsartan on these components of the intrarenal renin-angiotensin-aldosterone system was comparatively small. Although NHE3, NKCC, and ENaC expression was similar between the groups, NaCl cotransporter (NCC) expression was markedly suppressed by azilsartan (P < 0.05). Thus, in a mild chronic kidney disease (CKD) model with slight BP elevation, the sympatholytic effect of ARB might be expected, and azilsartan might exert its natriuretic effect by NCC suppression achieved by sympathoinhibitory activity.

Medical Science Monitor Basic Research

Comparative Analysis of Renin-Angiotensin System (RAS)-Related Gene Expression Between Hypertensive and Normotensive Rats

Article

作者: Khurana, Sandhya ; Byrne, Collin J ; Williamson, Chad R ; Tai, T C ; Nguyen, Phong

BACKGROUND The renal renin-angiotensin system (RAS) is physiologically important for blood pressure regulation. Altered regulation of RAS-related genes has been observed in an animal model of hypertension (spontaneously hypertensive rats - SHRs). The current understanding of certain RAS-related gene expression differences between Wistar-Kyoto rats (WKYs) and SHRs is either limited or has not been compared. The purpose of this study was to compare the regulation of key RAS-related genes in the kidneys of adult WKYs and SHRs. MATERIAL AND METHODS Coronal sections were dissected through the hilus of kidneys from 16-week-old male WKYs and SHRs. RT-PCR analysis was performed for Ace, Ace2, Agt, Agtr1a, Agtr1b, Agtr2, Atp6ap2 (PRR), Mas1, Ren, Rnls, and Slc12a3 (NCC). RESULTS Increased mRNA expression was observed for Ace, Ace2, Agt, Agtr1a, Agtr1b, and Atp6ap2 in SHRs compared to WKYs. Mas1, Ren, Slc12a3, and Rnls showed no difference in expression between animal types. CONCLUSIONS This study shows that the upregulation of several key RAS-related genes in the kidney may account for the increased blood pressure of adult SHRs.