更新于：2024-11-01

CD3ε x CD1A

更新于：2024-11-01

基本信息

关联

项与 CD3ε x CD1A 相关的药物

WO2023079425

专利挖掘

靶点

CD1A x CD3ε

作用机制-

在研机构

Università degli studi Magna Græcia di Catanzaro

原研机构

Università degli studi Magna Græcia di Catanzaro

在研适应症

血液及淋巴系统疾病

非在研适应症-

最高研发阶段药物发现

首次获批国家/地区-

首次获批日期1800-01-20

100 项与 CD3ε x CD1A 相关的临床结果

登录后查看更多信息

100 项与 CD3ε x CD1A 相关的转化医学

登录后查看更多信息

0 项与 CD3ε x CD1A 相关的专利（医药）

登录后查看更多信息

项与 CD3ε x CD1A 相关的文献（医药）

2023-12-26·Journal of Clinical and Experimental Hematopathology

Coincidence of <i>de novo</i> T-lymphoblastic lymphoma and cutaneous gamma/delta peripheral T-cell lymphoma

Article

作者: Satoh, Tsugumi ; Yasuda, Masanori ; Kohri, Mika ; Tanae, Ken ; Takahashi, Naoki ; Tsukasaki, Kunihiro ; Asou, Chie ; Kayano, Hidekazu

The coincidence of acute T-lymphoblastic leukemia/lymphoma, NOS (T-ALL/LBL), and peripheral T-cell lymphoma (PTCL) is unusual, and there have only been a few cases of their metachronous occurrence. In these cases, PTCLs emerged as recurrence after primary therapy for primary T-ALL, were the rare gamma/delta type, and uncommonly involved skin for T-ALL/LBL. We herein report the first case of de novo T-LBL that coincided with cutaneous gamma/delta PTCL before primary therapy. A 70-year-old man presented with systemic lymphadenopathy. Lymph node biopsy revealed a massive proliferation of lymphoblastoid cells; immunohistochemically, they were positive for TdT/CD1a/CD99, and cytoplasmic CD3ε, CD4, and CD8 and were negative for T-cell receptor (TCR) βf-1. A few TCRδ-positive cells were intermingled. Atypically, TIA was focally positive, whereas granzyme/perforin was negative. Multiple papules and plaques emerged on the trunk before the initiation of treatment for T-LBL. Skin biopsy revealed a massive proliferation of medium-to-large atypical lymphoid cells that were TdT/CD1a-negative mature T-cells; they were negative for TCRβf1 and CD4, and positive for TCRδ, CD5, CD8, CD56, TIA, granzyme B, and perforin. A conventional PCR analysis of TCRG showed no identical clonal band between the two tumors. The skin lesion was diagnosed as cutaneous gamma/delta T-cell lymphoma. Whether the lesion was primary or a transformation of T-LBL was unclear. After treating with reduced hyper-CVAD/MA targeting T-LBL, molecular complete remission was achieved. When an uncommon cutaneous lesion emerges in the course of T-ALL/LBL, both need to be evaluated pathologically and genetically, whether de novo or recurrent, assuming the possibility of coincident gamma/delta PTCL.

2017-12-01·Medicine4区 · 医学

Primary pulmonary extranodal NK/T-cell lymphoma of nasal type misdiagnosed as pneumonia

4区 · 医学

ReviewOA

作者: Yang, XiaoDong ; Liu, Chang ; Zhang, Juan ; He, Xin ; Wang, MaoJuan

RATIONALEPrimary pulmonary NK/T cell lymphoma is extremely rare, and only a few cases have reported so far. Its diagnosis is mainly dependent on open-lung biopsy.PATIENT CONCERNSHere, we report a 44-year-old male who was initially misdiagnosed as having pneumonia according to the clinical characteristics and computed tomography (CT) findings.DIAGNOSISThe first lung biopsy indicated a large number of coagulative necrotic lesions, and definite diagnosis was made after the second lung biopsy following non-response to 6-day wide spectrum antibiotic therapy. The second lung biopsy showed the tumor cells were positive for LCA, CD3ε, CD30, TIA-1, Ki67 and negative for CD20, CD56, CD1a, MPO, CK, S-100, desmin, and CD34.INTERVENTIONSThis patient refused to receive further therapy and died 1 month after confirmed diagnosis.OUTCOMESClinically, it is difficult to differentiate pneumonia from NK/T cell lymphoma in pathology due to the presence of plenty of focal necrosis in primary pulmonary NK/T cell lymphoma.LESSONSThe diagnosis of primary pulmonary NK/T cell lymphoma should be based on lung biopsy (usually multiple lung biopsies are required), immunohistochemistry and clinical and imaging findings.

2015-01-01·International journal of clinical and experimental pathology

Langerhans cell sarcoma arising from the root of tongue: a rare case.

Article

作者: Ren, Jian-Jun ; Liu, Ming-Juan ; Liu, Guo ; Chen, Fei ; Zhao, Yu

Langerhans cell sarcoma (LCS), a rare malignant disease with markedly malignant cytological features and poor outcome, originates from Langerhans cells and most commonly affects the lymph nodes, skin, and bone. This paper presents the case of a 58-year-old female with LCS at the root of her tongue, with neither local recurrence nor distant metastasis observed during 47 months of follow up following radiotherapy for more than one month after complete tumor resection. Histological and immunophenotypic tests revealed that the malignant tumor cells were positive for S-100 protein, CD1a, and LCA, and partially positive for CD3ε. By contrast, the tumor cells were negative for langenin, CD30, HMB45, PCK, CK5/6, and P63. Their Ki-67proliferation index ranged from 30% to 40%. This neoplasm was diagnosed as LCS according to the classification of WHO2008. This work is the first report on LCS arising from the root of tongue. This rare case may serve as a reference for future clinical studies.