预约演示
更新于：2025-03-06
CD19 x CD38
更新于：2025-03-06
关联
NCT06006741
Universal CAR-T Cells for the Treatment of Multiple Myeloma
NCT03291444
A Clinical Study of Chimeric Antigen Receptor T Cells Combined With Eps8 Peptide Specific Dendritic Cell for Patients With Relapsed/Refractory Leukemia and Myelodysplastic Syndromes
NCT03638206
Autologous Immunotherapy With Multi-target Gene-modified CAR-T/TCR-T Cell for Malignancies
100 项与 CD19 x CD38 相关的临床结果
登录后查看更多信息
100 项与 CD19 x CD38 相关的转化医学
登录后查看更多信息
登录后查看更多信息
2025-12-31ANNALS OF MEDICINE
The remodeling of B-cell subsets was correlated with the clearance of hepatitis B antigen during pegylated IFN α-2a therapy in CHB patients
Article
作者: Wu, Zeqian ; Tan, Lei ; Mo, Zhishuo ; Zhu, Jianyun ; Gao, Zhiliang ; Gan, Weiqiang
BACKGROUND:
B-cell may participate in the cellular immune process of hepatitis B antigen clearance. However, the function and specific mechanism of B-cell during interferon-pegylated interferon α-2a (Peg-IFN-α) treatment in chronic hepatitis B (CHB) patients have not yet been described.
METHODS:
A total of 150 CHB patients enrolled in this study, who received 48 weeks of Peg-IFN α treatment. The differentiation clusters CD19, CD24, CD27, CD38, CD40, and CD80 of B cell surface markers in CHB patients were detected by flow cytometry. Spearman correlation and Logistic regression analysis were performed for the analysis.
RESULTS:
The clearance rate of HBsAg increased significantly with the duration of Peg-IFN-α treatment, reaching 32.2% by 48 weeks. During the Peg-IFN-α therapy, the frequency of B-cell and its subsets increased significantly. However, we did not observe any significant difference in the frequency of the B-cell and its subsets in patients with or without HBsAg clearance after 48 weeks Peg-IFN-α treatment. The change in HBsAg value was negatively related to the change in plasmablasts (CD19+CD38+) level before and after 48 weeks treatment (r = -0.326, p = 0.006). Moreover, the results showed that HBsAg <288.70 IU/mL at baseline and HBsAg <58.05 IU/mL at 12 weeks were strong predictors of HBsAg clearance in patients with 48 weeks Peg-IFN-α treatment.
CONCLUSION:
The remodeling of B cell subsets, especially plasmablasts (CD19+CD38+), during Peg-IFN-α treatment was closed associated with the clearance of hepatitis B antigen.
2025-02-07MEDICINE
Bidirectional Mendelian randomization reveals causal immune cell phenotypes in rheumatoid arthritis
Article
作者: Lin, Quanzhi ; Huang, Luofei ; Shi, Jian ; Li, Han
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent inflammation in synovial joints and influenced by genetic and environmental factors. The immune system, comprising various cells that either exacerbate or reduce inflammation, plays a central role in RA pathogenesis. Despite extensive research, the causal relationships between immune cell phenotypes and RA remain unclear. We employed a two-sample Mendelian randomization (MR) approach to investigate the causal associations between 731 immune cell phenotypes and RA. Genetic variants, carefully selected based on rigorous criteria, served as instrumental variables to ensure analytical validity. Data on RA were derived from the FinnGen database, whereas immune cell phenotype data were obtained from the genome-wide association studies catalog. We employed 5 MR methods, including inverse variance weighted and MR Egger, to ensure robust causal inference. We assessed for pleiotropy and heterogeneity and adjusted findings using the False Discovery Rate. After False Discovery Rate adjustment (threshold < 0.05), inverse variance weighted analysis revealed potential causal relationships between 4 immune cell types and RA: CD62L− dendritic cells %dendritic cells (P = 3.88E‐05; 95% confidence interval [CI] = 1.056), CD19 on IgD+ CD38− naive cells (P = 1.75E‐04; 95% CI = 0.969), CD45RA on TD CD8br (P = 5.59E‐04; 95% CI = 0.919), and HLA DR on CD33− HLA DR+ (P = 8.13E‐05; 95% CI = 1.422). In reverse Mendelian studies, specific immune cell phenotypes were found to be associated with RA risk and progression: the percentage of memory B cells among lymphocytes (P = 2.74E‐04; 95% CI = 0.861), IgD+ CD24+ cells among lymphocytes (P = 6.93E‐04; 95% CI = 0.867), CD4+ CD8dim cells among lymphocytes (P = 2.92E‐04; 95% CI = 0.802), CD4+ CD8dim cells among leukocytes (P = 4.37E‐04; 95% CI = 0.814), and CD24 expression on IgD+CD24+ cells (P = 1.05E‐04; 95% CI = 0.857). These results identify immune cell phenotypes closely linked to RA susceptibility and progression. The findings suggest that specific immune cell phenotypes are not only influenced by RA but may also contribute to its development and progression. These results offer new insights into the immunological underpinnings of RA and highlight potential targets for therapeutic intervention. Future research should focus on validating these causal relationships in diverse populations and exploring the molecular mechanisms involved.
2025-02-01PEDIATRIC PULMONOLOGY
The Causal Role of Immune Cell Phenotypes and Inflammatory Factors in Childhood Asthma: Evidence From Mendelian Randomization
Article
作者: Feng, Zhoushan ; Chen, Xiaochun ; Han, Bin ; Mei, Jingwen ; Qiao, Shicun ; Jia, Chunhong ; Wu, Xiaohong ; Wu, Fan
ABSTRACT:
Objective:
This study utilizes Mendelian randomization (MR) to explore the causal relationship between immune cell phenotypes, inflammatory factors, and childhood asthma, aiming to enhance our understanding and management of the disease.
Methods:
A two‐sample MR approach was used to explore the causal relationships between 731 immune cell phenotypes, 91 inflammatory factors, and childhood asthma. The main analysis was performed using inverse variance weighting (IVW), with additional methods like weighted median, MR‐Egger, and weighted mode. Statistical significance was further assessed using false discovery rate (FDR) correction. Sensitivity analyses assessed heterogeneity (Cochran's Q test) and pleiotropy (MR‐Egger, MR‐PRESSO), while reverse causality was evaluated using the Steiger test. Findings were further validated through cohort studies and meta‐analyses to ensure robustness.
Results:
Among 91 inflammatory factors, DNER, IL‐18 R1, and Osteoprotegerin increased childhood asthma risk, while CDCP1 and VEGF‐A were protective (p < 0.05). Of 731 immune cell phenotypes, 45 showed significant links to asthma, with protective effects from CD45RA+ CD8+ T cells and HLA−DR+ NK cells, and increased risk from IgD‐CD38‐ B cells and CD8dim T cells (p < 0.05). Specific SSC‐A parameters and higher MFI values for CD19, CD28, and CD3 were protective, while elevated MFI for CCR2 on monocytes and CD86 on myeloid dendritic cells increased risk. However, after further FDR correction, no statistically significant results were identified. Nonetheless, sensitivity and replication analyses, including meta‐analysis, confirmed the robustness of these associations.
Conclusions:
This study provides a comprehensive investigation into the complex interplay between immune system dysregulation and childhood asthma. By identifying specific inflammatory factors and immune cell phenotypes linked to asthma risk and protection, the findings offer valuable insights into disease pathogenesis. While these results highlight potential targets for precision‐based therapeutic interventions, further research is needed to validate these associations and translate them into clinical applications.
分析
对领域进行一次全面的分析。
登录
或
来和芽仔聊天吧
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用