更新于:2024-05-01

AT1R

血管紧张素II-1型受体

基本信息

别名
1型血管紧张素受体、AG2S、AGTR1
+ [15]
简介
Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney (PubMed:1567413, PubMed:8987975, PubMed:15611106, PubMed:25913193, PubMed:26420482, PubMed:30639100, PubMed:32079768). The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C (PubMed:15611106). (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis.

分析

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对领域进行一次全面的分析。
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