更新于：2024-11-01

IL-2 x plectin

更新于：2024-11-01

基本信息

关联

项与 IL-2 x plectin 相关的药物

IL2-ep13nsEV

靶点

IL-2 x plectin

作用机制

IL2基因抑制剂 [+1]

在研机构

Wake Forest University

原研机构

Wake Forest University

在研适应症

乳腺癌

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期1800-01-20

100 项与 IL-2 x plectin 相关的临床结果

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100 项与 IL-2 x plectin 相关的转化医学

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0 项与 IL-2 x plectin 相关的专利（医药）

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项与 IL-2 x plectin 相关的文献（医药）

2021-07-01·Journal of Clinical Periodontology1区 · 医学

Genome‐wide association study of stage III/IV grade C periodontitis (former aggressive periodontitis) in a Spanish population

1区 · 医学

Article

作者: Lorenzo, Ramón ; Quintela, Inés ; Blanco, Juan ; de Coo, Alicia ; Sanz, Mariano ; Álvarez‐Novoa, Pablo ; Enrile, Francisco ; Blanco‐Moreno, José ; Alonso, Ángel ; Cruz, Raquel ; Vallcorba, Nuria ; Diz, Pedro ; Carracedo, Angel ; García, Roberto ; Noguerol, Blas ; Herrera, David ; Serrano, Cristina ; Rodríguez Grandío, Segundo ; Oteo, Alfonso ; Ramos, Isabel ; Zabalegui, Ion ; Esmatges, Alejandro ; Mateos, Leopoldo

AbstractAimTo identify loci associated with stages III/IV, grade C periodontitis (PIII/IV‐C) through a genome‐wide association study (GWAS).Materials and Methods441 Caucasian Spanish PIII/IV‐C cases from the SEPA Network of Research Clinics and 1141 controls from the BancoNacionaldeADN were genotyped with “Axiom Spain Biobank Array,” which contains 757836 markers, including rare and low‐frequency Spanish variants. The analysis of the individual association and subsequently the gene‐level analysis with Sequence Kernel Association Test (SKAT) were carried out adjusting for age, sex and PC1 covariates. Pathway Analysis was additionally performed with Ingenuity Pathway Analysis (IPA) software on the top associated genes.ResultsIn the individual analyses, no genome‐wide significant signals were detected. However, 8 SNPs of 8 loci reached suggestive evidence of association with PIII/IV‐C, including FAT3 rs35709256, CSNK1G2 rs4807188, MYH13 rs2074872, CNTN2 rs116611488, ANTXR1 rs4854545, 8p23.2 rs78672540, ANGPT1 rs13439823 and PLEC rs11993287 (p < 5 × 10−6). SKAT analysis identified other interesting signals at CNTN2, FBXO44, AP1M2, RSPO4, KRI1, BPIFB1 and INMT, although their probability does not exceed the multiple‐test correction. IPA indicated significant enrichment of pathways related to cAMP, IL‐2, CD28, VDR/RXR and PI3K/Akt. ConclusionsGWAS found no SNPs significantly associated with PIII/IV‐C.

1992-03-01·Molecular and Cellular Biology3区 · 生物学

cis-Acting Sequences Required for Inducible Interleukin-2 Enhancer Function Bind a Novel Ets-Related Protein, Elf-1

3区 · 生物学

Article

作者: Karpinski, Beverly ; Wang, Chung-Yih ; Zhang, Liquian ; Miesfeldt, Susan ; Leiden, Jeffrey M. ; Ho, I-Cheng ; Nabel, Gary J. ; Bohjanen, Paul R. ; Thompson, Craig B. ; Petryniak, Bronislawa ; June, Carl H.

The recent definition of a consensus DNA binding sequence for the Ets family of transcription factors has allowed the identification of potential Ets binding sites in the promoters and enhancers of many inducible T-cell genes. In the studies described in this report, we have identified two potential Ets binding sites, EBS1 and EBS2, which are conserved in both the human and murine interleukin-2 enhancers. Within the human enhancer, these two sites are located within the previously defined DNase I footprints, NFAT-1 and NFIL-2B, respectively. Electrophoretic mobility shift and methylation interference analyses demonstrated that EBS1 and EBS2 are essential for the formation of the NFAT-1 and NFIL-2B nuclear protein complexes. Furthermore, in vitro mutagenesis experiments demonstrated that inducible interleukin-2 enhancer function requires the presence of either EBS1 or EBS2. Two well-characterized Ets family members, Ets-1 and Ets-2, are reciprocally expressed during T-cell activation. Surprisingly, however, neither of these proteins bound in vitro to EBS1 or EBS2. We therefore screened a T-cell cDNA library under low-stringency conditions with a probe from the DNA binding domain of Ets-1 and isolated a novel Ets family member, Elf-1. Elf-1 contains a DNA binding domain that is nearly identical to that of E74, the ecdysone-inducible Drosophila transcription factor required for metamorphosis (hence the name Elf-1, for E74-like factor 1). Elf-1 bound specifically to both EBS1 and EBS2 in electrophoretic mobility shift assays. It also bound to the purine-rich CD3R element from the human immunodeficiency virus type 2 long terminal repeat, which is required for inducible virus expression in response to signalling through the T-cell receptor. Taken together, these results demonstrate that multiple Ets family members with apparently distinct DNA binding specificities regulate differential gene expression in resting and activated T cells.