别名 Glutathione synthase、Glutathione synthetase、GSH synthetase + [3] |
简介 Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner (PubMed:7646467, PubMed:9215686). Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes (PubMed:10369661). Participates in ophthalmate biosynthesis in hepatocytes (By similarity). |
靶点 |
作用机制 GSS刺激剂 |
非在研适应症 |
最高研发阶段批准上市 |
首次获批国家/地区 美国 |
首次获批日期2012-10-02 |
靶点 |
作用机制 GSS刺激剂 |
在研机构- |
在研适应症- |
最高研发阶段终止 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
开始日期2020-09-01 |
申办/合作机构 |
开始日期2013-01-03 |
申办/合作机构 |
开始日期2011-08-01 |
申办/合作机构 |