AGER

Podium presentation will include clinical updates from the Company's Phase 2 clinical trials investigating azeliragon, in combination with radiation therapy with or without temozolomide, in newly diagnosed glioblastoma WESTON, Fla., March 19, 2024 /PRNewswire/ -- Cantex Pharmaceuticals, Inc., a clinical stage pharmaceutical company focused on developing transformative therapies for cancer and other life-threatening medical conditions for which new treatments are urgently needed, announced today that the Company's CEO, Stephen Marcus, M.D., will be an expert speaker at 5th Annual Glioblastoma Drug Development Summit, which will be held March 26-28 at the Hilton Boston Logan Airport. In a podium presentation titled, "Delving into a Clinical Update on Azeliragon for GBM - Implementable Lessons for Small Molecule Success," Dr. Marcus will update the Company's progress with its two ongoing azeliragon Phase 2 clinical trials. In those clinical trials, azeliragon is being studied in combination with radiation therapy with or without temozolomide in patients with newly diagnosed glioblastoma (GBM). In addition, Dr. Marcus will also highlight azeliragon's potential effect on cerebral edema and its potential ability to reduce dexamethasone dosing in GBM treatment. GBM is a highly malignant primary brain tumor for which current therapeutic options provide a limited life extension benefit. In 2023, Cantex received Food and Drug Administration Orphan Drug Designation for azeliragon for the treatment of glioblastoma. FDA Orphan Drug Designation provides Cantex with seven years of azeliragon marketing exclusivity from the time of product launch for the orphan indication, and several other important benefits, including assistance in the drug development process, tax credits for clinical costs, and exemptions from certain FDA fees. "We look forward to meeting with esteemed colleagues and researchers to discuss the many important advances being made to combat this challenging and devastating form of cancer and azeliragon's progress in our two Phase 2 GBM clinical trials," said Dr. Marcus. "We are excited to discuss this novel clinical candidate and its unique mechanism of action, which we believe has the potential to impact several devastating cancers that continue to challenge researchers, oncologists, and patients." Details of the event are as follows: During the conference, Dr. Marcus will conduct one-on-one meetings to review the Company's business and clinical development strategy, recent corporate achievements, and upcoming milestones. About Azeliragon Azeliragon is an orally administered capsule, taken once daily, that inhibits interactions of the receptor for advanced glycation end products (known as RAGE) with certain ligands, including HMGB1 and S100 proteins in the tumor microenvironment. Azeliragon was discovered by and originally under development for Alzheimer's disease by vTv Therapeutics Inc. (NASDAQ: VTVT) from which Cantex licensed worldwide rights to azeliragon. Clinical safety data from these trials, involving more than 2000 individuals dosed for periods up to 18 months, indicate that azeliragon is very well tolerated. Cantex has ongoing Phase 2 clinical trials in glioblastoma, brain metastasis, pancreatic cancer, breast cancer, and a Phase 3 trial in hospitalized patients with pneumonia to prevent acute kidney injury. These trials are based on azeliragon's robust preclinical data as well as its extensive clinical safety information from randomized placebo-controlled clinical trials. About Cantex Pharmaceuticals, Inc. Cantex Pharmaceuticals, Inc. is a privately held, clinical stage pharmaceutical company focused on developing transformative therapies for cancer and other life-threatening medical conditions for which new treatments are urgently needed. For more information, please visit . About vTv Therapeutics Inc. vTv Therapeutics Inc. is a clinical stage biopharmaceutical company focused on developing oral, small molecule drug candidates, led by cadisegliatin (TTP399), a potentially transformative treatment for the reduction of hypoglycemic episodes in type 1 diabetes patients. To learn more please visit vtvtherapeutics.com. Contact Information: Tiberend Strategic Advisors, Inc. Investors Daniel Kontoh-Boateng +1 862-213-1398 dboateng@tiberend.com Media Casey McDonald +1 646-577-8520 cmcdonald@tiberend.com Cantex Pharmaceuticals, Inc. Stephen G. Marcus, M.D. +1 954-315-3660 info@cantex.com Juan F. Rodriguez +1 954-315-3660 info@cantex.com Company Codes: NASDAQ-NMS:VTVT

WESTON, Fla., Feb. 22, 2024 /PRNewswire/ -- Cantex Pharmaceuticals, Inc., a clinical stage pharmaceutical company focused on developing transformative therapies for cancer and other life-threatening medical conditions for which new treatments are urgently needed, announced today that Stephen Marcus, M.D., Chief Executive Officer, will participate in the BIO CEO & Investor Conference being held February 26-27, 2024 in New York City. During the conference, Dr. Marcus will conduct one-on-one meetings with registered investors, showcasing the Company's business and clinical development strategy, recent corporate achievements, and anticipated milestones. Cantex is developing azeliragon, an oral inhibitor of the receptor for advanced glycation end products (known as RAGE). Cantex has ongoing Phase 2 clinical trials in top US and EU medical centers in glioblastoma, brain metastasis, metastatic pancreatic cancer, and breast cancer, and a Phase 3 randomized, placebo-controlled clinical trial in hospitalized patients with pneumonia. Details of the event are as follows: About Azeliragon Azeliragon is an orally administered capsule, taken once daily, that inhibits interactions of the receptor for advanced glycation end products (known as RAGE) with certain ligands, including HMGB1 and S100 proteins in the tumor microenvironment. Azeliragon was discovered by and originally under development for Alzheimer's disease by vTv Therapeutics Inc. (NASDAQ: VTVT), from which Cantex licensed worldwide rights to azeliragon. Clinical safety data from these trials, involving more than 2,000 individuals dosed for periods up to 18 months, indicate that azeliragon is very well tolerated. Cantex has multiple ongoing clinical trials as noted above. These trials are based on azeliragon's robust preclinical data as well as its extensive clinical safety information from randomized placebo-controlled clinical trials. About Cantex Pharmaceuticals, Inc. Cantex Pharmaceuticals, Inc. is a privately held, clinical stage pharmaceutical company focused on developing transformative therapies for cancer and other life-threatening medical conditions for which new treatments are urgently needed. For more information, please visit . About vTv Therapeutics Inc. vTv Therapeutics Inc. is a clinical stage biopharmaceutical company focused on developing oral, small molecule drug candidates, led by cadisegliatin (TTP399), a potentially transformative treatment for the reduction of hypoglycemic episodes in type 1 diabetes patients. To learn more please visit vtvtherapeutics.com. Contact Data: Tiberend Strategic Advisors, Inc. Investors Daniel Kontoh-Boateng +1 862-213-1398 [email protected] Media Casey McDonald +1 646-577-8520 [email protected] Cantex Pharmaceuticals, Inc. Stephen G. Marcus, M.D. +1 954-315-3660 [email protected] Juan F. Rodriguez +1 954-315-3660 [email protected] SOURCE Cantex Pharmaceuticals, Inc.

VILLANOVA, Pa.--(BUSINESS WIRE)-- Galactica Pharmaceuticals, Inc., a biopharmaceutical company focused on developing novel fusion protein molecules, announced today the online publication of its recent COVID-19 in vivo animal data at bioRxiv. Based on three studies in both the mouse and hamster COVID models, Galactica’s investigational RAGE (Receptor for Advanced Glycation End Products) fusion protein is the first and only molecule to have demonstrated both a statistically significant survival benefit and reduction in viral load. The full study, “Anti-Viral and Anti-Inflammatory Therapeutic Effect of RAGE-Ig Protein Against Multiple SARS-CoV-2 Variants of Concern Demonstrated in K18-hACE2 Mouse and Syrian Golden Hamster Models” can be found at . If these very encouraging preclinical data are replicated in human studies, we anticipate that in the treatment of COVID-19 patients, Galactica’s RAGE protein could potentially: Save the lives of many hospitalized COVID-19 patients; Enable COVID-19 patients to be discharged from ICU units and hospitals faster by simultaneously reducing their viral load; Reduce the likelihood that infected patients will spread the virus to others. “Having studied this molecule in eight in vivo animal studies across various disease areas and generated strong data in each one, we remain optimistic that our RAGE protein may prevent the vast majority of COVID-related deaths. We look forward to advancing our RAGE investigational drug into a Phase I/II COVID clinical trial in the coming months. Our investigational drug is expected to initially target hospitalized COVID patients requiring ventilation or expected to do so imminently,” said Lawrence Brown, Galactica’s Chief Executive Officer. “As COVID-19 continues to mutate and prove fatal for certain patient populations, it is imperative that we develop new, effective therapeutics to treat these vulnerable patients,” said Lbachir BenMohamed, Ph.D., Galactica's preclinical COVID investigator. ”Millions of recovered COVID patients are still experiencing long- term COVID symptoms, often for many months post-recovery. Given the unique anti-inflammatory and anti-viral dual benefit of Galactica’s investigational drug, it will be interesting to observe whether this molecule is effective against long COVID symptoms in human populations.” The expected primary endpoint of Galactica’s initial Phase I/II COVID clinical trial is survival. If that endpoint is met, Galactica expects to seek Emergency Use Authorization (EUA) from the United States Food and Drug Administration to quickly make the drug available to hospitalized COVID-19 patients. About RAGE RAGE (Receptor for Advanced Glycation End Products) is the AGEs-specific multi-ligand receptor involved in inflammatory responses to various chronic inflammatory lung diseases. RAGE is known to be highly expressed in the lungs, especially in the alveolar epithelial cells (AECs), in comparison to other organs of the human body. The RAGE pathway has been reported in the pathogenesis of lung diseases such as chronic obstructive pulmonary disease (COPD), interstitial lung diseases, and ARDS. In recent years, the therapeutic intervention of the RAGE pathway has been demonstrated to benefit patients suffering from ARDS, COPD, pulmonary fibrosis, and other pathologies associated with the pulmonary system. RAGE has also been postulated to contribute to diabetic complications by binding a variety of molecules, including AGEs, HMGB1, S100, and integrins. Such interactions lead to inflammatory processes, including the upregulation of adhesion molecules, generation of cytokines and reactive oxygen species, and upregulation of monocyte chemoattractant protein 1, at least in part through the activation of NF-ĸB. The mechanisms by which RAGE inhibitors have been postulated to work include by being a scavenger for soluble AGEs, by acting as a competitive antagonist for membrane-bound RAGEs and for the full-length biologically active RAGEs, and by binding HMGB1 to prevent its interaction with membrane RAGEs. About Galactica Pharmaceuticals, Inc. Galactica is an “IND-ready” biopharmaceutical company focused exclusively on the development of its novel, proprietary RAGE fusion protein. While the initial indication is expected to be the treatment of lung inflammation and Cytokine Storm symptomatic of COVID-19, the molecule is also under development for the treatment of diabetes and diabetic complications and both the dry and wet forms of macular degeneration. Learn more: .