预约演示

更新于：2025-01-23

登革热E蛋白

更新于：2025-01-23

基本信息

别名-

简介-

关联

项与登革热E蛋白相关的药物

VIS-513

靶点

登革热E蛋白

作用机制

登革热E蛋白抑制剂

在研机构

Visterra, Inc.

原研机构

Visterra, Inc.

在研适应症

登革热

非在研适应症-

最高研发阶段临床2期

首次获批国家/地区-

首次获批日期1800-01-20

项与登革热E蛋白相关的临床试验

NCT06551844

/ Not yet recruiting临床2期IIT

Adaptive Dengue Antiviral Platform Trial (ADAPT): a Phase 2 Randomized, Adaptive, Open Label Trial for Antiviral Screening in Patients With Early Symptomatic Dengue

This is a randomized, open-label adaptive platform trial aiming to screen the antiviral effectiveness of the experimental drug(s) in early dengue infection
* Primary objectives:
* To determine the antiviral effectiveness of the experimental drug(s) in early dengue infection
* To assess the safety and tolerability of the experimental drug(s) in dengue patients
* Secondary objective:
* To assess the effect of the experimental drug(s) in dengue patients on physiological, clinical and virological parameters

开始日期2025-09-01

申办/合作机构

Oxford University Clinical Research Unit, Vietnam

[+1]

100 项与登革热E蛋白相关的临床结果

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100 项与登革热E蛋白相关的转化医学

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0 项与登革热E蛋白相关的专利（医药）

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项与登革热E蛋白相关的文献（医药）

2025-02-01·Colloids and Surfaces B: Biointerfaces

Self-assembly of differently charged trimesic based lithocholic amphiphiles and their assessment on antimicrobial and biostimulant properties

Article

作者: Govindaraju, Kasivelu ; Rajendiran, Nagappan ; Kannan, Malaichamy ; Govindaraj, Kasivelu ; Panchalingam, Santhiya ; Kasthuri, Jayapalan ; Ezhumalai, Nishanthi

Biosurfactant based biostimulants plays a vital role in agriculture filed by enhancing the soil quality, promote plant growth, and eliminate plant pathogens, and increasing nutrient uptake. This manuscript describes the synthesis of trimesic based lithocholic ester functionalized amphiphiles (TMLCEA) with oppositely charged head groups using thiol-yne click chemistry, which is an effective and simple approach. The trimesic based lithocholic ester functionalized zwitterionic penicillamine (TMLCEPA), cationic cysteamine·HCl (TMLCECy), and anionic thiomalic acid (TMLCETM) exhibited hierarchically self-assembled microstructures from below to above the CMC. In below the CMC, TMLCEPA, TMLCECy, and TMLCETM showed a bundle of petals, flower-like morphology, and grass seed-like patterns respectively. The morphology of self-assembly was studied by FE-SEM, DLS, OPM, contact angle, and zeta potential measurements. Among these amphiphiles, TMLCECy exhibited potential antimicrobial activity at above the CMC. The biostimulant effect of different concentration of TMLCEA treated with maize and green gram seeds were evaluated under in vitro condition, wherein TMLCECy showed improved seed germination and seedling parameters at 750 µL/mL as compared to TMLCEPA, TMLCETM and untreated amphiphiles as control. Molecular docking and molecular dynamic simulations show that TMLCEPA and TMLCETM showed higher binding affinity for dengue methyltransferase protein. The result of the present study opens up new avenues for bile acid-based amphiphiles as bio-based and cost-effective biostimulants for sustainable agriculture.

2023-01-01·Journal of Vector Borne Diseases

Epitope prediction and designing of receptor inhibitor of Dengue Envelope Protein: An in silico approach

Article

作者: Kumari, Ankita ; Singh, Karuna ; Uttam, Gunjan

BACKGROUND & OBJECTIVESDengue virus (DENV) is the causative agent of dengue fever (DF) and dengue hemorrhagic fever (DHF). It has four distinct serotypes (DENV-1, DENV-2, DENV-3, and DENV-4) based on their antigenic properties. Mostly, the immunogenic epitopes are present in the envelope (E) protein of the virus. Heparan sulfate (HS) acts as a receptor and interacts with the E protein of the virus thus facilitating the entry of dengue virus into human cells. This study focuses on epitope prediction on the E protein of the DENV serotype. The non-competitive inhibitors of HS were designed using bioinformatics.METHODSIn the present study, epitope prediction of the E protein of DENV serotypes was performed using the ABCpred server and IEDB analysis resource. The interactions of HS and viral E proteins (PDB ID: 3WE1 and PDB ID:1TG8) were evaluated through AutoDock. Subsequently, non-competitive inhibitors were designed to bind the E protein of DENV better than HS. All the docking results were validated by re-docking the ligand-receptor complexes and superimposing them onto their co-crystallized complexes using AutoDock and visualizing them in Discovery Studio.RESULTSThe result predicted B-cell and T-cell epitopes on the E protein of DENV serotypes. The designed HS ligand 1 (non-competitive inhibitor) demonstrated potential binding with the DENV E protein, thereby inhibiting HS-E protein binding. The re-docked complexes were superimposed entirely onto the native co-crystallized complexes (low root mean square deviation values), which validates the docking protocols.INTERPRETATION & CONCLUSIONThe identified B-cell and T-cell epitopes of the E protein and non-competitive inhibitors of HS (ligand 1) could be used in the designing of potential drug candidates against the dengue virus.

2022-02-01·Mini-Reviews in Medicinal Chemistry3区 · 医学

Dengue Virus Entry/Fusion Inhibition By Small Bioactive Molecules: A Critical Review

3区 · 医学

Review

作者: Pottabatula, Shyam Sunder ; Naresh, Podila ; Jubie, Selvaraj

:Many flaviviruses are remarkable human pathogens that can be transmitted by mosquitoes and ticks. Despite the availability of vaccines for viral infections such as yellow fever, Japanese encephalitis, and tick-borne encephalitis, flavivirus-like dengue is still a significant life-threatening illness worldwide. To date, there is no antiviral treatment for dengue therapy. Industry and the research community have been taking ongoing steps to improve anti-flavivirus treatment to meet this clinical need. The successful activity has been involved in the inhibition of the virus entry fusion process in the last two decades. In this study, the latest understanding of the use of small molecules used as fusion inhibitors has been comprehensively presented. We summarized the structure, the process of fusion of dengue virus E protein (DENV E), and the amino acids involved in the fusion process. Special attention has been given to small molecules that allow conformational changes to DENV E protein, viz. blocking the pocket of βOG, which is important for fusion.

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