别名 胰高血糖素受体、GCGR、GGR + [2] |
简介 G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system. |
靶点 |
作用机制 GCGR激动剂 |
非在研适应症 |
最高研发阶段批准上市 |
首次获批国家/地区 美国 |
首次获批日期2021-03-22 |
靶点 |
作用机制 GCGR激动剂 |
在研机构 |
最高研发阶段批准上市 |
首次获批国家/地区 美国 |
首次获批日期2019-09-10 |
开始日期2024-07-01 |
申办/合作机构 Columbia University [+2] |
开始日期2024-06-10 |
申办/合作机构 |
开始日期2024-05-08 |
申办/合作机构 |