主要研究目的研究空腹/餐后状态下单次口服给药受试制剂盐酸贝尼地平片（规格：8 mg，由江苏诚康药业有限公司生产，灵康药业集团股份有限公司提供）与参比制剂盐酸贝尼地平片（可力洛®，规格：8 mg；Kyowa Kirin Co., Ltd.持证，灵康药业集团股份有限公司提供）在健康成年受试者体内的药代动力学，评价空腹/餐后状态下两种制剂的生物等效性。次要研究目的研究受试制剂盐酸贝尼地平片和参比制剂盐酸贝尼地平片（可力洛®）在健康成年受试者中的安全性。

开始日期-

申办/合作机构

灵康药业集团股份有限公司

CTR20240452 / CompletedN/A

卡维地洛片（10mg）空腹/餐后状态下在健康受试者中的生物等效性试验

主要目的：在健康男性与女性受试者中于空腹/餐后条件下，评价受试制剂卡维地洛片（规格：10 mg，生产商：浙江华海药业股份有限公司）和 Daiichi Sankyo Co., Ltd.为持证商的参比制剂卡维地洛片（ARTIST，规格： 10 mg）的生物等效性。次要目的：观察受试制剂卡维地洛片与参比制剂卡维地洛片（ARTIST）在健康受试者中的安全性。

开始日期2024-03-09

申办/合作机构

浙江华海药业股份有限公司

CTR20234308 / CompletedN/A

卡维地洛片（10mg）健康人体生物等效性研究

主要目的：本研究以福安药业集团宁波天衡制药有限公司生产的卡维地洛片（规格：10mg）为受试制剂，按生物等效性研究的有关规定，以原研厂家Daiichi Sankyo Co., Ltd.生产的卡维地洛片（规格：10mg，商品名：ARTIST®）为参比制剂，评估受试制剂和参比制剂在空腹/餐后条件下给药后的生物等效性。次要目的：观察受试制剂卡维地洛片和参比制剂卡维地洛片（ARTIST®）在健康受试者中的安全性。

开始日期2024-01-22

申办/合作机构

福安药业集团宁波天衡制药有限公司

100 项与肾实质性高血压相关的临床结果

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100 项与肾实质性高血压相关的转化医学

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0 项与肾实质性高血压相关的专利（医药）

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104

项与肾实质性高血压相关的文献（医药）

2021-12-09·Vnitřní lékařství

Renoparenchymatózní hypertenze - aktuality v diagnostice a léčbě

Article

作者: Oulehle, Kateřina ; Ciferská, Hana ; Zakiyanov, Oskar ; Vachek, Jan ; Tesař, Vladimír

Renal parenchymal disease is the most common cause of secondary hypertension, accounting for up to 5% cases of all cases of systemic hypertension. Renal parenchymal hypertension occurs as a complication of a wide variety of glomerular and tubulointerstitial diseases and may aggravate the decline of kidney function. The pathophysiology of renal parenchymal hypertension represents a combined interaction of the impaired sodium handling leading to volume expansion, alteration of the renin-angiotensin system, abnormalities in endogenous vasodepressor compounds and possibly enhanced activity of vasoactive substances. Renal parenchymal hypertension can occur in acute and chronic kidney disease, manifesting early in the renal function impairment. It often requires complex pharmacological treatment of blood pressure and is prognostically unfavorable in terms of cardiovascular and renal complications. This form of secondary hypertension can often be successfully treated by therapy of the underlying renal disease. In case of insufficient blood pressure compensation, renal impairment progresses. The aim of this paper is to give a brief overview of renoparenchymatous hypertension, current diagnostic possibilities and principles of therapy.

2019-12-01·Experimental Physiology

Hydrogen inhalation attenuated bleomycin‐induced pulmonary fibrosis by inhibiting transforming growth factor‐β1 and relevant oxidative stress and epithelial‐to‐mesenchymal transition

Article

作者: Jiang, Dingyuan ; Geng, Jing ; Dong, Run ; Dai, Huaping ; Gao, Li

NEW FINDINGS• What is the central question of this study? The aim was to explore the effects and underlying mechanisms of H₂ on bleomycin-induced pulmonary fibrosis. • What are the main findings and its importance? Our results indicate that, in bleomycin-induced pulmonary fibrosis, H₂ inhalation attenuated oxidative stress and reversed the pulmonary epithelial-to-mesenchymal transition process by reducing reactive oxygen species production and inhibiting the expression of transforming growth factor-β1, α-smooth muscle actin and collagen I to improve fibrotic injury and exert anti-fibrogenic effects. Thus, H₂ inhalation has promising therapeutic potential as a useful adjuvant treatment for patients with idiopathic pulmonary fibrosis, which deserves further study and evaluation.ABSTRACTHydrogen (H₂ ) can protect against tissue damage. The effect of H₂ inhalation therapy on the pathogenesis of pulmonary fibrosis remains unknown. This study was designed to explore the effects and underlying mechanisms of H₂ inhalation on bleomycin (BLM)-induced pulmonary fibrosis. A rat model of pulmonary fibrosis was established with BLM. Rats were randomly divided into control and H₂ inhalation groups. Haematoxylin and Eosin staining and Mason's Trichrome staining were performed to evaluate pulmonary fibrosis injury, inflammatory cell infiltration, structural disorder and collagen deposition. qRT-PCR and western blot assays were used to determine the expression of TNF-α, TGF-β1, α-SMA, E-cadherin, N-cadherin, vimentin, VEGF and collagen type I at both mRNA and protein levels. The contents of reactive oxygen species, TGF-β1, TNF-α, malondialdehyde and hydroxyproline were determined with biochemical test kits or ELISA kits. Bleomycin-stimulated rats exhibited typical symptoms of pulmonary fibrosis, which featured an increase in collagen deposition, alveolitis, fibrosis and parenchymal structural disorder in the lung. However, BLM-induced oxidative stress was attenuated by H₂ inhalation therapy, which reduced the contents of reactive oxygen species, malondialdehyde and hydroxyproline, enhanced the activity of glutathione peroxidase and decreased the expression of TGF-β1 and TNF-α. In addition, H₂ inhalation also inhibited BLM-induced epithelial-to-mesenchymal transition by inhibiting TGF-β1, increasing the expression level of the epithelial cell marker E-cadherin, and decreasing the expression level of the mesenchymal cell marker vimentin in a time-dependent manner. In addition, H₂ inhalation downregulated α-SMA expression and suppressed collagen I generation, exerting anti-fibrogenic effects. Hydrogen inhalation therapy attenuates BLM-induced pulmonary fibrosis by inhibiting TGF-β1, relevant oxidative stress and epithelial-to-mesenchymal transition.

2019-02-01·Experimental and Molecular Pathology4区 · 医学

HIVAN associated tubular pathology with reference to ER stress, mitochondrial changes, and autophagy

4区 · 医学

Review

作者: Sanketh Andhavarapu ; Girma Asemu ; Harry Davis ; Vivek Patel ; Akhil Katuri ; Joseph L. Bryant ; Tapas K. Makar ; Dhruvil Patel

Human immunodeficiency virus associated nephropathy (HIVAN) is a unique form of a renal parenchymal disorder. This disease and its characteristics can be accredited to incorporation of DNA and mRNA of human immunodeficiency virus type 1 into the renal parenchymal cells. A proper understanding of the intricacies of HIVAN and the underlying mechanisms associated with renal function and disorders is vital for the potential development of a reliable treatment for HIVAN. Specifically, the renal tubule segment of the kidney is characterized by its transport capabilities and its ability to reabsorb water and salts into the blood. However, the segment is also known for certain disorders, such as renal tubular epithelial cell infection and microcyst formation, which are also closely linked to HIVAN. Furthermore, certain organelles, like the endoplasmic reticulum (ER), mitochondria, and lysosome, are vital for certain underlying mechanisms in kidney cells. A paradigm of the importance of said organelles can be seen in documented cases of HIVAN where the renal disorder results increased ER stress due to HIV viral propagation. This balance can be restored through the synthesis of secretory proteins, but, in return, the secretion requires more energy; therefore, there is a noticeable increase in mitochondrial stress. The increased ER changes and mitochondrial stress will greatly upregulate the process of autophagy, which involves the cell's lysosomes. In conjunction, we found that ER stress and mitochondrial changes are associated in the Tg26 animal model of HIVAN. The aim of our review is to consolidate current knowledge of important mechanisms in HIVAN, specifically related to the renal tubules' association with ER stress, mitochondrial changes and autophagy. Although the specific regulatory mechanism detailing the cross-talk between the various organelles is unknown in HIVAN, the continued research in this field may potentially shed light on a possible improved treatment for HIVAN.