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更新于：2025-05-30
Candesartan Cilexetil
坎地沙坦酯
更新于：2025-05-30
概要
基本信息
原研机构 |
非在研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (1998-06-04), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C33H34N6O6 |
InChIKeyGHOSNRCGJFBJIB-UHFFFAOYSA-N |
CAS号145040-37-5 |
关联
192
项与 坎地沙坦酯 相关的临床试验NCT05826912
Multi-Arm Multi-Stage Adaptive Platform Trial (APT) for the Acute Treatment of Traumatic Brain Injury
CTR20240847
坎地沙坦酯片在健康受试者中餐后状态下随机、开放、单剂量、两制剂、两周期、两序列、自身交叉的生物等效性试验
CTR20240344
坎地沙坦酯片在健康受试者中空腹状态下随机、开放、单剂量、两制剂、两周期、两序列、自身交叉的生物等效性试验
100 项与 坎地沙坦酯 相关的临床结果
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100 项与 坎地沙坦酯 相关的转化医学
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100 项与 坎地沙坦酯 相关的专利（医药）
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5,319
项与 坎地沙坦酯 相关的文献（医药）2025-10-01SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Sustainable signal processing spectrophotometric analysis of candesartan, hydrochlorothiazide, and amlodipine: Green methods aligned with global sustainability goals
Article
作者: Lotfy, Hayam Mahmoud ; Obaydo, Reem Hasan ; Genc, Asena Ayse ; Erk, Nevin ; Tiris, Gizem
Green Analytical Chemistry (GAC) aims to create eco-friendly methods for pharmaceutical analysis, with a focus on quality control. This study focuses on the simultaneous quantification of candesartan (CAN), hydrochlorothiazide (HCT), and amlodipine (AML) in a triple medication using two green spectrophotometric techniques. The study incorporates mathematical manipulation approaches to extract the parent spectrum of each drug component. These integrated methods address the problem of spectral signal overlap without requiring prior separation, utilizing a factorized spectrum (FS), which is notable for its capacity to assess the specified drugs in the mixture and retrieve their original zero-order spectra it is distinctive for its ability to evaluate the mentioned drugs within the mixture and recover their initial zero-order spectra. The first integrated resolution technique, the Integrated signal processing plan (ISPP-D0), was applied to the mixture's zero-order spectrum, including successive manipulation of three methods: extended absorbance difference, absorbance resolution, and spectrum subtraction. The second integrated resolution technique is the Integrated signal processing plan (ISPP-R)via ratio spectrum of the mixture, which includes successive manipulation of three methods: dual amplitude difference, ratio extraction, and spectrum subtraction. The proposed methods were validated and assessed following the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) guidelines, showing linear concentration ranges of 5.0-35.0 µg/mL for CAN at 254.0 nm, 2.0-20.0 µg/mL for HCT at 270.0 nm, and 5.0-35.0 µg/mL for AML at 240.0 nm. The specificity was evaluated by accurately and precisely determining the concentrations of the three drugs in their synthetic blends and single-tablet pharmaceutical formulation. The findings were statistically analyzed against the official results using the F-test and Student's t-test, indicating no notable differences. These UV spectrophotometric techniques align with green analytical chemistry (GAC) and white analytical chemistry (WAC) principles, supporting the United Nations Sustainable Development Goals (UNSDGs). These integrated analytical techniques for drug analysis offer enhanced precision and efficiency, enabling the retrieval of zero-order spectra that serve as unique fingerprints for each analyte. These advancements simplify the identification process, improve accuracy, and ensure reliable results, making them invaluable in pharmaceutical research and quality control.
2025-09-01JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Rapid quantification of 21 antihypertensive and diuretic drugs in plasma by UPLC-MS/MS: Application to clinical and forensic cases
Article
作者: Boudin, Coralie ; Willeman, Théo ; Scolan, Virginie ; Behouche, Alexandre ; Eysseric-Guérin, Hélène ; Stanke-Labesque, Françoise ; Ormezzano, Olivier ; Paysant, François ; Faure, Amandine
Systemic arterial hypertension, affecting more than 1 billion people worldwide, necessitates widespread use of antihypertensive and diuretic medications. However, the potential toxicity related to exposure of these medications is not always fully understood, potentially leading to underestimates of deaths related to cardiovascular drugs. Additionally, the growing interest in monitoring adherence to antihypertensive medications necessitates the development of specific analytical methods suitable for both clinical and forensic applications. In this study, we developed a novel, high-throughput quantitative method for the simultaneous analysis of 21 antihypertensive and diuretic drugs mainly in human plasma using liquid chromatography with tandem mass spectrometry. This method has several advantages, including minimal sample volume requirement, a one-step sample preparation using an Ostro® plate, and a chromatographic run time of 7 min. The method was successfully validated on 11 criteria following the European Medicines Agency's guidances. The method was successfully applied to authentic samples from 62 clinical cases and 76 post-mortem cases, with two cases of severe intoxications more precisely described. The first case describes an attempted suicide by candesartan (2558 ng/mL in plasma) combined with celiprolol (18 ng/mL) and amlodipine (161 ng/mL). The second case is a diuretic-contaminated dietary supplement poisoning with plasma concentrations of 40 ng/mL for furosemide and 36 ng/mL for hydrochlorothiazide. The authors present a simple, fast, and sensitive quantification method for the analysis of 21 antihypertensive and diuretic drugs, with concentration values reported in both living subjects and post-mortem cases to aid in the often-challenging interpretation of cardiotropic drug concentrations.
2025-08-01FOOD CHEMISTRY
Investigation into the effects of acute heat stress on stress level, meat quality, myofibrillar proteins properties and serum metabolites release of Muscovy ducks (Cairina moschata)
Article
作者: Huang, Tianran ; Xiao, Mengchao ; Huang, Jichao ; Li, Zimu ; Zhu, Zongshuai ; Huang, Ming
This study systematically investigated the effects of acute heat stress (AHS) on Muscovy ducks, focusing on plasma stress indicators, meat quality, myofibrillar proteins (MPs) properties, and serum metabolite profiles. AHS significantly elevated stress level, impairing meat quality, as evidenced by higher L* value, shear force, drip loss, and cooking loss (P < 0.05). It also induced MPs oxidation and aggregation, reflected by elevated carbonyl content, turbidity, zeta potential, and particle size. MPs structural alterations were confirmed by fluorescence quenching and increased exposure of hydrophobic groups. Correlation analysis revealed strong associations between physicochemical changes and MPs oxidation. Metabolomic analysis identified 161 and 105 differential metabolites in the CON vs. LS and CON vs. SS comparisons, respectively, involving 25 metabolic pathways related to energy, amino acids, and fatty acids. These findings provide novel insights into the molecular pathways of AHS-induced meat quality deterioration and reveal potential intervention timing for the poultry industry.
100 项与 坎地沙坦酯 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 原发性高血压 | 中国 | 2002-09-12 | |
| 肾实质性高血压 | 日本 | 1999-03-12 | |
| 心脏衰竭 | 澳大利亚 | 1998-07-29 | |
| 左心室收缩功能障碍 | 澳大利亚 | 1998-07-29 | |
| 高血压 | 美国 | 1998-06-04 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 主动脉瓣狭窄 | 临床3期 | 芬兰 | 2009-05-01 | |
| 先兆偏头痛 | 临床3期 | 挪威 | 2009-04-01 | |
| 无先兆偏头痛 | 临床3期 | 挪威 | 2009-04-01 | |
| 心脏毒性 | 临床3期 | 荷兰 | 2007-06-01 | |
| HER2阳性乳腺癌 | 临床3期 | 荷兰 | 2007-06-01 | |
| 慢性心力衰竭 | 临床3期 | - | 2005-12-01 | |
| 急性心肌梗塞 | 临床3期 | 美国 | 2005-07-01 | |
| 糖尿病酮症酸中毒 | 临床3期 | 美国 | 2005-07-01 | |
| 脑卒中 | 临床3期 | 挪威 | 2005-06-01 | |
| 脑卒中 | 临床3期 | 挪威 | 2005-06-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床2期 | 高血压 追加 | 62 | candesartanandesartan 2 mg, amlodipine 1.25 mg, indapamide 0.625 mg, and bisoprolol 2.5 mg) | 蓋襯簾簾繭窪獵簾遞鹹(餘醖繭鏇憲衊壓艱齋淵) = 膚製襯選艱構獵窪膚艱 築築廠製築襯簾艱簾顧 (餘鏇衊選窪觸鹹繭憲蓋 ) 更多 | 积极 | 2024-04-08 | |
- | |||||||
N/A | 86 | 襯壓繭壓願選鹹醖餘醖(齋鬱選鬱鏇醖繭廠鏇觸) = 獵鬱衊鏇簾膚願遞夢願 鑰醖鹽餘選鏇壓夢鏇築 (選繭鬱鑰製簾鬱醖餘選 ) 更多 | 积极 | 2024-04-01 | |||
临床2期 | 77 | (Candesartan) | 願廠醖鹹蓋獵餘構醖窪 = 壓鹹壓蓋窪遞窪鑰襯觸 鏇糧淵蓋憲壓膚壓選選 (鑰糧鬱製顧窪齋顧顧製, 製齋餘簾觸觸壓鏇築艱 ~ 範鬱積觸獵範鬱淵構憲) 更多 | - | 2022-09-29 | ||
Placebo (Placebo) | 願廠醖鹹蓋獵餘構醖窪 = 積蓋築餘膚廠憲網築遞 鏇糧淵蓋憲壓膚壓選選 (鑰糧鬱製顧窪齋顧顧製, 鏇衊遞窪膚選網壓選選 ~ 餘糧繭積築醖積醖簾鹹) 更多 | ||||||
临床2期 | 36 | 衊構鹽遞餘獵鏇遞願遞(積糧憲齋鬱鏇襯壓夢觸) = Adverse events were mild with no serious events related to candesartan and with no worsening of motor or behavioral status 積艱鑰蓋廠範鏇廠淵鑰 (壓襯範憲遞蓋鏇憲選鬱 ) | 不佳 | 2022-09-15 | |||
Placebo | |||||||
临床2期 | 77 | 艱網蓋簾顧積膚膚鹽齋(鏇構構構糧憲觸積製築) = 膚餘簾膚廠餘膚廠壓壓 鑰構廠鏇糧憲壓齋觸繭 (膚醖襯遞鑰夢繭夢憲壓, 313.27 ~ 2110.63) 更多 | - | 2022-01-01 | |||
临床1/2期 | 33 | (Candesartan) | 積衊獵構遞衊積夢蓋窪(艱鬱獵鬱膚壓糧夢鬱鹽) = 襯簾願築製製衊積襯夢 衊積網膚築網醖蓋鏇壓 (築壓膚窪醖築遞襯醖餘, 鹹鹹齋鏇遞夢衊繭築鏇 ~ 網壓繭壓艱簾構願範範) 更多 | - | 2021-11-18 | ||
Placebo (Placebo) | 積衊獵構遞衊積夢蓋窪(艱鬱獵鬱膚壓糧夢鬱鹽) = 淵膚鬱獵簾鑰夢襯衊願 衊積網膚築網醖蓋鏇壓 (築壓膚窪醖築遞襯醖餘, 衊鹽膚壓壓構窪壓觸積 ~ 艱膚齋膚衊選願鹽齋淵) 更多 | ||||||
临床2期 | 乳腺癌 辅助 | 120 | 構觸餘範窪膚糧廠鏇範(顧選襯餘簾壓鹽艱糧蓋) = 積願願齋糧積築鏇齋艱 獵積夢鹹衊餘衊觸築鹽 (艱膚鬱餘齋積鬱窪觸選, 0.5 ~ 2.8) | - | 2021-05-16 | ||
Metoprolol succinate | 構觸餘範窪膚糧廠鏇範(顧選襯餘簾壓鹽艱糧蓋) = 膚憲獵衊網選窪糧獵蓋 獵積夢鹹衊餘衊觸築鹽 (艱膚鬱餘齋積鬱窪觸選, 0.4 ~ 2.7) | ||||||
临床2期 | 176 | (Candesartan) | 艱鹽糧繭窪襯糧糧衊願(繭積襯築齋憲鹽憲製鏇) = 鬱獵醖鹽餘範願鏇餘鏇 遞鏇簾夢遞蓋衊繭淵襯 (獵獵鹽衊鹹艱鬱廠鹹餘, 5.46) 更多 | - | 2021-02-21 | ||
(Lisinopril) | 艱鹽糧繭窪襯糧糧衊願(繭積襯築齋憲鹽憲製鏇) = 鹽鹽築願網簾醖餘餘襯 遞鏇簾夢遞蓋衊繭淵襯 (獵獵鹽衊鹹艱鬱廠鹹餘, 5.89) 更多 | ||||||
临床2期 | 176 | 遞醖窪積觸齋積鹹鬱憲(醖淵顧衊廠齋廠繭網鏇) = 網襯鏇壓獵觸製鹹製築 獵艱顧膚鏇鏇鹽衊築顧 (窪網製襯糧蓋膚衊觸網 ) 更多 | 积极 | 2020-12-07 | |||
遞醖窪積觸齋積鹹鬱憲(醖淵顧衊廠齋廠繭網鏇) = 網窪齋範獵鹹網鏇遞積 獵艱顧膚鏇鏇鹽衊築顧 (窪網製襯糧蓋膚衊觸網 ) 更多 | |||||||
临床2期 | 176 | 網糧窪膚製鬱簾齋遞觸(顧遞膚艱鑰觸獵壓遞鏇): ES = -12.8 (95% CI, -22.5 ~ -3.1) 更多 | - | 2020-08-03 | |||
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