Hypothesis of "AN-ACC pathological network" suggests that ACC overactivation and abnormal functional connectivity with other brain regions is the neuropathological mechanism for the onset of AN. Currently, rare studies have been conducted on dTMS targeting ACC as an intervention in patients with AN. In this research, dTMS, a neuroregulatory technology, is used for the first time to intervene with ACC in the treatment of adult AN. A randomized controlled study design is adopted, in which patients with AN are divided into the dTMS treatment group and the pseudo-stimulation group by 1:1 randomization, followed by 6-week intervention and half-year follow up, to clarify the near-term and long-term efficacy and safety of the dTMS treatment. Meanwhile, baseline fMRI data will be extracted and combined with clinical features to establish an efficacy prediction model, which will provide theoretical and practical basis for the pioneering ACC-targeted dTMS treatment in China, helping to establish a new type of intervention program for AN, with expected results of innovation.

开始日期2024-04-30

申办/合作机构

上海市精神卫生中心（上海市心理咨询培训中心）

[+3]

NCT05553782 / Not yet recruiting早期临床1期IIT

Therapeutic Drug Screening Using a Novel Implantable Microdevice (IMD) in Adenoid Cystic Carcinoma (ACC) and Salivary Cancers: a Window of Opportunity Study

This research study is studying the effect of different drugs as possible treatments for adenoid cystic carcinoma (ACC), a type of head and neck cancer.
The name of the study intervention involved in this study is:
-implantable microdevice

开始日期2023-11-01

申办/合作机构

Dana-Farber Cancer Institute, Inc.

NCT04706845 / CompletedN/A

Understanding the Burden of ACC Through the Eyes of Patients

This is a comprehensive, cross-sectional study conducted with approximately 40-60 individuals affected by ACC who may know the results of molecular profiling of their tumor.
Primary Objectives:
To identify the specific burdens faced by patients with ACC
To compare/contrast the burdens faced by patients with ACC at different disease stages (no evident disease, metastatic disease/watchful waiting, progressive disease)

开始日期2021-01-11

申办/合作机构

Ayala Pharmaceuticals, Inc.

[+2]

100 项与乙酰辅酶A羧化酶缺乏症相关的临床结果

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100 项与乙酰辅酶A羧化酶缺乏症相关的转化医学

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0 项与乙酰辅酶A羧化酶缺乏症相关的专利（医药）

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567

项与乙酰辅酶A羧化酶缺乏症相关的文献（医药）

2024-12-01·Molecular Biology Reports

Fetal agenesis of corpus callosum: chromosomal copy number abnormalities and postnatal follow-up

Article

作者: Lin, Na ; Fu, Meimei ; Xu, Liangpu ; Cai, Meiying ; Que, Yanting ; Huang, Hailong

AbstractObjectiveAgenesis of the corpus callosum (ACC) is an anomaly that can occur in fetuses during pregnancy. However, there is currently no treatment for fetal ACC. Therefore, we conducted a retrospective analysis of obstetric outcomes of fetal ACC to explore the relationship between fetal ACC phenotypes and chromosomal copy number abnormalities.Methods and resultsAmniotic fluid or umbilical cord blood were extracted from pregnant women with fetal ACC for karyotype analysis and chromosomal microarray analysis (CMA). Among the 48 fetuses with ACC, 22 (45.8%, 22/48) had isolated ACC, and 26 (54.2%, 26/48) had non-isolated ACC. Chromosomal abnormalities were detected via karyotype analysis in four cases. In addition to the four cases of pathogenic copy number variations (CNVs) detected using karyotype analysis, CMA revealed two cases of pathogenic CNVs with 17q12 microduplication and 16p12.2 microdeletion. The obstetric outcomes of 26 patients with non-isolated ACC were followed up, and 17 chose to terminate the pregnancy. In addition, seven of the nine cases with non-isolated ACC showed no obvious abnormality during postnatal follow-up, whereas only one case with normal CMA showed an abnormal phenotype at six months. Of the 22 patients with isolated ACC, six chose to terminate the pregnancy. Postnatal follow-up of 16 isolated ACC cases revealed only one with benign CNV, presenting with intellectual disability.ConclusionPregnant women with fetal ACC should be offered prenatal CMA, particularly non-isolated ACC. Patients with ACC should undergo prolonged postnatal follow-up, and appropriate intervention should be provided if necessary.

2024-09-06·The Oncologist

A review of mitotane in the management of adrenocortical cancer

Review

作者: Gilbert, Jill ; Srinivas, Sandy ; Tito Fojo, Antonio ; Hallanger-Johnson, Julie ; Kiseljak-Vassiliades, Katja ; Bancos, Irina ; Del Rivero, Jaydira ; Aboujaoude, Emily ; Raj, Nitya ; Vaidya, Anand ; Else, Tobias ; Reidy-Lagunes, Diane

AbstractImportanceMitotane (Lysodren, o,p'-DDD [1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane)] is currently the only United States Food and Drug Administration and European Medicines Agency-approved product for the treatment of adrenocortical carcinoma.ObservationsMitotane is challenging to administer; however, its toxicities (specifically adrenal insufficiency) are well known, and the management of adverse consequences has established approaches. While often viewed through the prism of a cytotoxic agent, it can also interfere with hormone production making it a valuable asset in managing functional ACC. A recently completed prospective trial has shed some light on its use in the adjuvant setting, but further clarity is needed. Many think mitotane has a role in the advanced or metastatic setting, although prospective data are lacking and retrospective analyses are often difficult to interpret.Conclusions and relevanceWhen used carefully and thoughtfully, especially in patients with hormonal excess, mitotane is an important component of the treatment armamentarium for ACC.

2024-09-01·Biochemical and Biophysical Research Communications

Socially activated neurons in the anterior cingulate cortex are essential for social behavior in mice

Article

作者: Takemoto, Tomoya ; Seiriki, Kaoru ; Kitagawa, Kohei ; Hashimoto, Hitoshi ; Nakazawa, Takanobu ; Kasai, Atsushi

Social behavior, defined as any mode of communication between conspecifics is regulated by a widespread network comprising multiple brain structures. The anterior cingulate cortex (ACC) serves as a hub region interconnected with several brain regions involved in social behavior. Because the ACC coordinates various behaviors, it is important to focus on a subpopulation of neurons that are potentially involved in social behavior to clarify the precise role of the ACC in social behavior. In this study, we aimed to analyze the roles of a social stimulus-responsive subpopulation of neurons in the ACC in social behavior in mice. We demonstrated that a subpopulation of neurons in the ACC was activated by social stimuli and that silencing the social stimulus-responsive subpopulation of neurons in the ACC significantly impaired social interaction without affecting locomotor activity or anxiety-like behavior. Our current findings highlight the importance of the social stimulus-responsive subpopulation of neurons in the ACC for social behavior and the association between ACC dysfunction and impaired social behavior, which sheds light on therapeutic interventions for psychiatric conditions.