更新于：2024-11-01

Complications associated with artificial fertilization

人工授精相关并发症

更新于：2024-11-01

基本信息

别名

Complication associated with artificial fertilisation, unspecified、Complication associated with artificial fertilization, unspecified、Complications associated with artificial fertilisation

+ [5]

简介-

关联

项与人工授精相关并发症相关的药物

Corifollitropin alfa

靶点

FSHR

作用机制

FSHR激动剂

在研机构

Merck Sharp & Dohme Corp. [+1]

原研机构

Merck Sharp & Dohme Corp.

在研适应症

性腺机能减退 [+2]

非在研适应症

人工授精相关并发症 [+4]

最高研发阶段批准上市

首次获批国家/地区

欧盟 [+3]

首次获批日期2010-01-25

项与人工授精相关并发症相关的临床试验

IRCT20130812014333N223 / SuspendedN/AIIT

Evaluation of safety and effectiveness of placenta mesenchymal stem cell-derived exosomes on embryo implantation rate in women with recurrent implantation failure: a clinical trial

开始日期2024-09-05

申办/合作机构

Kermanshah University of Medical Sciences

NCT06433518 / Not yet recruitingN/AIIT

What Should Be The Optimal Ovulation Triggering Size in Poseidon Group 4 Patients Undergoing Ovarian Stimulation?

This observational clinical study aims to determine the optimal timing of ovulation triggering in women aged 35 and above with poor ovarian reserve.
For this purpose, cases undergoing ovarian stimulation for assisted reproductive treatment and planned final oocyte triggering will be evaluated in two separate groups:
1. **Experimental Group**: Final oocyte triggering will be performed when the follicle or follicles measure between 13-16 mm.
2. **Control Group**: Final oocyte triggering will be performed when the follicle or follicles measure greater than 17 mm.
All triggers will be administered uniformly with 6500 units of recombinant hCG and 0,2 mg triptorelin injections.
The primary outcome of the study will be the number of mature oocytes. Secondary outcomes will include fertilization rates, embryo counts, and implantation rates.
Primary and secondary outcomes will be compared between the two groups.

开始日期2024-07-01

申办/合作机构

Centrum Clinic IVF Center

IRCT20160422027520N23 / SuspendedN/AIIT

Investigating the effect of intrauterine injection of Extracellular vesicles derived from human umbilical cord Wharton's Jelly mesenchymal stem cells in the healing process of women with intrauterine adhesions(Asherman syndrome)

开始日期2024-04-03

申办/合作机构

Tabriz University of Medical Sciences

100 项与人工授精相关并发症相关的临床结果

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100 项与人工授精相关并发症相关的转化医学

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0 项与人工授精相关并发症相关的专利（医药）

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项与人工授精相关并发症相关的文献（医药）

2022-07-18·Computational and Mathematical Methods in Medicine

Effect Analysis of Degranulated Cell in Early Fertilization on FET Outcome and Offspring Safety with Data Mining

Article

作者: Chen, Bo ; Zhou, Liling ; Li, Qingyang ; Liu, Rongju ; Zhao, Li

In vitro fertilization and embryo transfer is one type of assisted reproductive technology, although the technology is now more mature. Many factors, however, will have an impact on oocyte fertilization, embryo growth, pregnancy outcome, and child safety due to the journey from clinical to the laboratory. The influence of degranulated cells early in fertilization on frozen embryo transfer (FET) results is investigated in this study. This article analyzes 255 patients who underwent in vitro fertilization (IVF) and FET transplantation at the author’s central unit from January 1, 2015, to June 30, 2021. Among them, IVF-assisted conception is the early degranulation of homologous oocyte fertilization. Correlation analysis is performed by observing the embryonic outcome of the early degranulation group and the overnight fertilization group and the clinical outcome after FET. Through data mining analysis, the results show that the polyfertilization rate and 0PN rate for the early degranulation group are significantly higher than the overnight fertilization group (9.87% vs. 8.24% and 3.14% vs. 1.69%). In terms of normal fertilization rate, there is no significant difference between D3 high-quality embryo rate and D5 high-quality blastocyst rate (64.07% vs. 65.15%, 27.5% vs. 26.5%, and 15.97% vs. 17.35%). There is no significant difference in the complete recovery rate of embryos after thawing (93.24% vs. 93.46%), and the implantation rate, clinical pregnancy rate, abortion rate, and live birth rate are not significantly different between the two groups after FET. The offspring outcomes of singletons do not differ significantly between the two groups; however, twins born early degranulate have much greater rates of ultralow birth weight and ultrapreterm children than twins born overnight fertilization (14.29% vs. 0). Therefore, it can be concluded that degranulation of cells early in fertilization is a desirable method to prevent fertilization disorders. However, under the premise of ensuring that no fertilization disorder occurs, it is not appropriate to degranulate all the oocytes of the patient at the early stage of fertilization.

2016-01-01·Zhonghua nan ke xue = National journal of andrology

[Normal sperm morphology and the outcomes of routine in vitro fertilization].

Article

作者: He, Bing ; Qin, Jie ; Mao, Xian-bao ; Tan, Wei-hong ; Pan, Qi ; Cheng, Jun-ping ; Chi, Yan ; Huang, Tai-shuai

OBJECTIVETo explore the application value of morphology assessment of sperm from fresh semen in routine in vitro fertilization (IVF).METHODSWe analyzed the morphology of the sperm from fresh or optimized semen samples and, based on the sperm morphology of the raw semen, allocated 908 IVF cycles due to the pure tubal factor to different groups: morphologically normal sperm (MNS) ≤ 4%, > 4% - ≤ 15%, and > 15% in Trial 1 and MNS ≤ 1%, > 1% - ≤ 2%, > 2% - ≤ 3%, and > 3%-- ≤ 4% in Trial 2. We compared the rates of fertilization, cleavage, high-quality embryo, -blastocyst formation, and pregnancy among different groups.RESULTSThe total fertilization rate was significantly lower in the MNS ≤ 4% than in the MNS > 4% - ≤ 15% and >15% groups (74.40% vs 78.61% and 80.03%, P < 0.01). Compared with the MNS ≤ 1%, > 1% - ≤ 2%, and > 2% - ≤ 3% groups, the MNS > 3% - ≤ 4% group showed remarkably increased rates of 2PN normal fertilization (77.23%, 78.97% and 78.99% vs 85.47%, P < 0.01), cleavage (95.71%, 96.01% and 97.27% vs 98.73%, P < 0.05), and blastocyst formation (53.85%, 49.01% and 49.55% vs 63.41%, P < 0.01). No statistically significant differences were observed in the rates of clinical pregnancy, implantation, early abortion, live birth, or malformation at birth among different groups (P > 0.05).CONCLUSIONMNS ≤ 4% affected the total rate of fertilization while MNS ≤ 3% reduced the rate of normal fertilization in IVF. However, even MNS ≤ 1% did not result in fertilization disorder or failure. Therefore, teratozoospermia alone was not an indicator of ICSI and sperm mor- phology assessment had no obvious value for predicting the rates of embryo quality, clinical pregnancy, and live birth in IVF.