预约演示

更新于：2025-05-07

Teratoma, Testicular

睾丸畸胎瘤

更新于：2025-05-07

基本信息

别名

TERATOMA, TESTICULAR、TESTICULAR TERATOMA、TESTIS, TERATOMA

+ [23]

简介

A non-seminomatous germ cell tumor arising from the testis. It is characterized by the presence of various tissues which correspond to the different germinal layers (endoderm, mesoderm, and ectoderm). Testicular teratomas in children follow a benign clinical course whereas in postpubertal patients may metastasize to other anatomic sites.

关联

项与睾丸畸胎瘤相关的药物

Ipilimumab

伊匹木单抗

靶点

CTLA4

作用机制

CTLA4抑制剂

在研机构

Bristol Myers Squibb Co. [+12]

原研机构

Bristol Myers Squibb Co.

在研适应症

晚期肝细胞癌 [+305]

非在研适应症

复发性急性淋巴细胞白血病 [+98]

最高研发阶段批准上市

首次获批国家/地区

美国

首次获批日期2011-03-25

项与睾丸畸胎瘤相关的临床试验

JPRN-UMIN000054107

/ RecruitingN/AIIT

A trial to evaluate the feasibility of using radio-controlled miniature cars to reduce preoperative anxiety in children. - A trial to evaluate the feasibility of using radio-controlled miniature cars to reduce preoperative anxiety in children.

开始日期2024-03-20

申办/合作机构

Kyushu University

JPRN-jRCTs031180410

/ Recruiting临床3期IIT

A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients with Germ Cell Tumors; AGCT1531

开始日期2020-05-22

申办/合作机构-

NCT01434355

/ CompletedN/AIIT

Molecular Epidemiology of Pediatric Germ Cell Tumors

This research trial studies deoxyribonucleic acid (DNA) samples from younger patients with germ cell tumor and their parents or siblings. Studying samples of tumor tissue and saliva from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

开始日期2011-11-01

申办/合作机构

The Children's Oncology Group Foundation, Inc.

[+1]

100 项与睾丸畸胎瘤相关的临床结果

登录后查看更多信息

100 项与睾丸畸胎瘤相关的转化医学

登录后查看更多信息

0 项与睾丸畸胎瘤相关的专利（医药）

登录后查看更多信息

747

项与睾丸畸胎瘤相关的文献（医药）

2025-01-01·BMJ Case Reports

Spigelian hernia and cryptorchidism syndrome: open spigelian hernia repair and laparoscopic one-stage orchiopexy for ectopic testis

Article

作者: Ablatt, Saniya ; Escobar, Mauricio Antonio

Spigelian hernia and cryptorchidism syndrome in children is increasingly reported in the literature. A variety of phenotypes have been reported, so diagnostic approaches and operative techniques remain poorly defined. The case of an infant male who presented with a left spigelian hernia and ipsilateral cryptorchidism who was initially misdiagnosed with an ectopic inguinal testis is presented. He underwent diagnostic laparoscopy which revealed an ectopic left testis within the spigelian hernia defect with a gubernaculum present. Collaborative decision making between paediatric surgery and paediatric urology resulted in the final operative repair entailing laparoscopic orchiopexy, open left spigelian and inguinal hernia repair, right inguinal hernia repair and umbilical hernia repair. We conclude that a laparoscopic orchiopexy of an ectopic testis within a spigelian hernia is a safe method to address this rare phenomenon, but collaborative multidisciplinary discussion is ideal to weigh operative strategies and management.

2025-01-01·IJU Case Reports

Total en bloc spondylectomy in testicular immature teratoma: Long‐term survival amidst vertebral metastasis escalated by growing teratoma syndrome

Article

作者: Ito, Noriyuki ; Maruno, Kouhei ; Tamaki, Masahiro ; Kikkawa, Kazuro ; Nakashima, Masakazu ; Yamada, Yuya ; Takahashi, Toshifumi ; Hazama, Tatsuya

IntroductionWe present a rare case of long‐term survival following metastasectomy for lumbar metastasis with growing teratoma syndrome.Case presentationAn 18‐year‐old man presented with left scrotal mass and lumbago. Alpha‐fetoprotein was elevated to 648.8 ng/mL, while human chorionic gonadotropin and lactate hydrogenase were normal. Pathology of left inguinal orchiectomy revealed immature teratoma, and computed tomography confirmed a single metastasis in the second lumbar vertebra. After two courses of bleomycin, etoposide, cisplatin chemotherapy, alpha‐fetoprotein decreased, but computed tomography confirmed an enlarged lumbar metastasis. A vertebral biopsy demonstrated teratoma with a dominant mature component, and growing teratoma syndrome was suspected. Following additional etoposide, cisplatin chemotherapy, and normalization of alfa‐fetoprotein, total spondylectomy was performed. Vertebral pathology proved mature teratoma. After adjuvant chemotherapy, he has been recurrence‐free for 17 years.ConclusionSpondylectomy of a single metastatic vertebra contributed to long‐term survival in a testicular teratoma case.

2024-12-01·Journal of Cancer Research and Therapeutics

Characteristics and prognosis of testicular mixed teratoma and seminoma

Article

作者: Li, Kai ; Fan, Caibin ; Sun, Fengdan

ABSTRACTBackground:To evaluate the association of demographic and clinicopathological characteristics with the survival of patients with testicular mixed teratoma and seminoma (TMTS).Methods:The data of 3296 eligible patients with TMTS who underwent surgery between 2010 and 2015 were obtained from the Surveillance, Epidemiology, and End Results database. Overall survival (OS) and cancer-specific survival (CSS) were determined using the Kaplan–Meier survival curves. The association of demographic and clinicopathological characteristics with the OS and CSS of patients with TMTS was assessed using the Cox proportional hazard regression model.Results:The number of patients with TMTS increased annually. In Kaplan–Meier analyses, TMTS patients with advanced T stage (P < 0.001 for OS and P < 0.001 for CSS), lymph node metastasis (P < 0.001 for OS and P < 0.001 for CSS), distant metastasis (P < 0.001 for OS and P < 0.001 for CSS), no regional lymph node resection (P = 0.003 for OS and P = 0.002 for CSS), large tumor size (P = 0.001 for OS and P = 0.001 for CSS), and LVI (P < 0.001 for OS and P < 0.001 for CSS) exhibited inferior OS and CSS. Moreover, distant metastasis (HR 11.224, P < 0.001; HR 15.817, P < 0.001) and regional lymph node resection (HR 0.425, P = 0.003; HR 0.366, P = 0.004) were identified as independent prognostic factors for OS and CSS in patients with TMTS through multivariable analyses.Conclusions:Distant metastasis and lymph node metastasis were deemed important prognostic factors for OS and CSS in patients with TMTS. Therefore, a comprehensive understanding and clinical assessments of these prognostic factors are necessary before tailoring clinical management and treatment plan specified for patients with TMTS.

分析

对领域进行一次全面的分析。

或

查看完整样例数据

Eureka LS:

全新生物医药AI Agent 覆盖科研全链路，让突破性发现快人一步

立即开始免费试用!

智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。

立即开始数据试用!

智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。