Efficacy of Racecadotril in Addition to Standard Treatment i in Decreasing the Duration of Acute Diarrhoea in Children as Compared to Standard of Treatment Alone

Acute watery diarrhea is defined as the passage of 3 or more loose or liquid stools per day for 3 or more days but less than 14 days, including patients with mild to moderate dehydration per WHO classification. The study's outcome variables are stool frequency, measured by the total number of stools passed during 24 and 48 hours from the initiation of treatment, and hospital duration, measured by the total duration of hospital stay in hours. The null hypothesis states that racecadotril combined with standard treatment has no effect on reducing the mean number of stools passed during 48 hours compared to standard treatment alone in pediatric patients with acute watery diarrhea, while the alternate hypothesis suggests that racecadotril combined with standard treatment will significantly reduce the mean number of stools passed during 48 hours compared to standard treatment alone in these patients.

开始日期2024-08-02

申办/合作机构

Liaquat National Hospital & Medical College

ChiCTR2400082597 / Recruiting临床4期IIT

A multicentre, randomised, double-blind, positive drug-controlled clinical study of the efficacy and safety of Fengliao Changweikang Keli in the treatment of acute diarrhoea (Damp-Heat syndrome) in adults

开始日期2024-04-01

申办/合作机构

中国中医科学院西苑医院

ChiCTR2300074826 / Suspended早期临床1期IIT

Effects of probiotic preparations on the treatment of diarrhea in college students

开始日期2023-09-01

申办/合作机构-

100 项与急性腹泻相关的临床结果

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100 项与急性腹泻相关的转化医学

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0 项与急性腹泻相关的专利（医药）

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项与急性腹泻相关的文献（医药）

2025-01-01·International Journal of Food Microbiology

Novel insights into biofilm formation and the key differentially expressed genes in Yersinia enterocolitica from meat: Implications for food safety and disease prevention

Article

作者: Wu, Yue ; Chen, Zongzong ; Xiao, Xiao ; Fang, Zhiguo ; Lou, Xiuqin ; Zhang, Qian

Yersinia enterocolitica is an important foodborne pathogen that can cause a zoonotic disease known as yersiniosis, which causes symptoms such as acute diarrhea, mesenteric adenitis, terminal ileum inflammation, pseudo appendicitis, sepsis, and other complications. The mechanism of biofilm formation in Y. enterocolitica remains poorly understood, with limited research available on this topic. This study systematically examined the distribution characteristics and biofilm formation ability of Y. enterocolitica isolated from poultry and livestock related samples. Analysis of food samples collected indicated significant presence of Y. enterocolitica (207/670, 30.9 %), particularly in frozen duck meat (7/11, 63.6 %). Majority of the isolated strains did not demonstrate biofilm-forming ability (52.7 %), while a notable percentage exhibited moderate (6.8 %) to strong (11.6 %) biofilm-forming ability. Additionally, a significant percentage of strains (16/207, 7.7 %) displayed extremely high optical density/cut-off OD (OD/ODC) ratios (the average OD value of each sample divided by the average OD value of the negative controls of each 96-well plate plus 3 standard deviations) (exceeding 10). Time-course analysis of biofilm formation in 10 isolates revealed three distinct patterns: (i) rapid increase from 6 h to 12 h, with gradual peak between 48 and 72 h followed by a slight decline and stabilization; (ii) little biofilm formation at 24 h with a gradual increase up to 96 h, maintaining this level until 120 h; and (iii) complete absence of biofilm formation throughout the experiment. Subsequent examination of differentially expressed genes (DEGs) in planktonic cells and biofilms of two strains with distinct biofilm formation capabilities identified seven metabolic pathways, including ribosome, photosynthesis, fatty acid degradation, valine, leucine, and isoleucine degradation, as well as pinene, camphor, and geraniol degradation. Significantly elevated expression levels of genes associated with flagellar assembly, bacterial chemotaxis, and quorum sensing (partially) were observed exclusively in planktonic cells of the selected strain with stronger biofilm-forming ability, implying that the heightened expression of flagellar assembly and bacterial chemotaxis-related genes is an important but not sole determinant of biofilm formation. The study contributes to the elucidation of the underlying mechanisms governing biofilm formation in Y. enterocolitica and may offer valuable insights for the advancement of novel food safety strategies.

2024-12-31·Expert Review of Vaccines

Combatting infectious diarrhea: innovations in treatment and vaccination strategies

Review

作者: Apostolopoulos, Vasso ; Mishra, Toshika ; Punetha, Swati ; Sharma, Nikita ; Dargahi, Narges ; Sairam, Anand ; Kamaraj, Sathvika ; Vuppu, Suneetha ; Vaghela, Dixa ; Chavda, Vivek P

INTRODUCTIONThe escalating prevalence of infectious diseases is an important cause of concern in society. Particularly in several developing countries, infectious diarrhea poses a major problem, with a high fatality rate, especially among young children. The condition is divided into four classes, namely, acute diarrhea, invasive diarrhea, acute bloody diarrhea, and chronic diarrhea. Various pathogenic agents, such as bacteria, viruses, protozoans, and helminths, contribute to the onset of this condition.AREAS COVEREDThe review discusses the scenario of infectious diarrhea, the prevalent types, as well as approaches to management including preventive, therapeutic, and vaccination strategies. The vaccination techniques are extensively discussed including the available vaccines, their advantages as well as limitations.EXPERT OPINIONThere are several approaches available to develop new-improved vaccines. In addition, route of immunization is important and aerosols/nasal sprays, oral route, skin patches, powders, and liquid jets to minimize needles can be used. Plant-based vaccines, such as rice, might save packing and refrigeration costs by being long-lasting, non-refrigerable, and immunogenic. Future research should utilize predetermined PCR testing intervals and symptom monitoring to identify persistent pathogens after therapy and symptom remission.

2024-12-31·Emerging Microbes & Infections

Coinfection and nonrandom recombination drive the evolution of swine enteric coronaviruses

Article

作者: Song, Wenbo ; Xiao, Shaobo ; Fang, Liurong ; Zhou, Junwei ; Guo, Jiahui ; Yang, Zhixiang ; Lai, Yinan ; Su, Wen ; Li, Zhuang

Coinfection with multiple viruses is a common phenomenon in clinical settings and is a crucial driver of viral evolution. Although numerous studies have demonstrated viral recombination arising from coinfections of different strains of a specific species, the role of coinfections of different species or genera during viral evolution is rarely investigated. Here, we analyzed coinfections of and recombination events between four different swine enteric coronaviruses that infect the jejunum and ileum in pigs, including porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), and swine acute diarrhea syndrome coronavirus (SADS-CoV), and a deltacoronavirus, porcine deltacoronavirus (PDCoV). Various coinfection patterns were observed in 4,468 fecal and intestinal tissue samples collected from pigs in a 4-year survey. PEDV/PDCoV was the most frequent coinfection. However, recombination analyses have only detected events involving PEDV/TGEV and SADS-CoV/TGEV, indicating that inter-species recombination among coronaviruses is most likely to occur within the same genus. We also analyzed recombination events within the newly identified genus Deltacoronavirus and found that sparrows have played a unique host role in the recombination history of the deltacoronaviruses. The emerging virus PDCoV, which can infect humans, has a different recombination history. In summary, our study demonstrates that swine enteric coronaviruses are a valuable model for investigating the relationship between viral coinfection and recombination, which provide new insights into both inter- and intraspecies recombination events among swine enteric coronaviruses, and extend our understanding of the relationship between coronavirus coinfection and recombination.

项与急性腹泻相关的新闻（医药）

2024-09-20

·医药地理

智能驱动，协同升级｜Pharma Match赋能供需对接新篇章

在快速迭代的科技引领型医疗健康领域，供需协同作为贯穿基础研究、生产制造、深入市场的核心链条，其效率与精确度直接影响着行业的创新能力与长远发展。然而，当前的医疗健康市场供需对接遭遇诸多挑战，传统方式过度依赖人工操作与直接沟通，不仅程序复杂、耗时费力，而且在信息传递环节极易出现偏差与不对称，严重阻碍了企业对市场变化的即时感知与灵活应对，进一步加剧了资源的错配与成本的上升。正是在此紧迫形势下，Pharma Match横空出世，为这一困境带来了革命性的突破方案。依托其创新的平台架构，Pharma Match正在逐步重塑医疗健康行业的供需对接格局。随着该平台的不断拓展与广泛应用，一个全新的、基于智能技术的医疗健康供需对接时代正加速到来。扫描下方二维码发布需求，开启您的医药行业供需对接之旅，体验高效、智能的合作新模式。产品供给奥恬萍®米格列醇片：化学制剂。用于改善成人2型糖尿病患者血糖控制。美消丹®红金消结片：化学制剂。用于气滞血瘀所致乳腺小叶增生，子宫肌瘤卵巢囊肿。维朴芬®醋氯芬酸肠溶片：化学制剂。用于治疗骨关节炎、类风湿性关节炎和强直性脊椎炎等引起的疼痛和炎症的症状治疗。维动啉®多潘立酮片：化学制剂。用于缓解恶心和呕吐症状；用于功能性消化不良，反流性食管炎，糖尿病胃轻瘫等治疗。清立停®蒙脱石散：化学制剂。用于成人及儿童急、慢性腹泻；用于食道、胃、十二指肠疾病引起的相关疼痛症状的辅助治疗。铝碳酸镁片：化学制剂。主要用于治疗胆酸相关性疾病，急、慢性胃炎，反流性食管炎，胃、十二指肠溃疡，与胃酸有关的胃部不适症状，也可以预防非甾体类药物的胃粘膜损伤。二甲硅油乳剂：化学制剂。可用于用于改善因为肠道内的气体过多而引起的腹部症状。磷酸钠盐散：化学制剂。用于患者肠道内窥镜检查前清理肠道、患者手术前清理肠道、患者结肠X-光线检查前清理肠道。氨茶碱口服溶液：化学制剂。适用于支气管哮喘、喘息性支气管炎、阻塞性肺气肿等缓解喘息症状；也可用于心源性肺水肿引起的哮喘。盐酸氨溴索口服溶液：化学制剂。用于治疗急、慢性呼吸道疾病引起的痰液黏稠，咳痰困难；预防呼吸道感染。铝碳酸镁咀嚼片：化学制剂。适应症：慢性胃炎；与胃酸有关的胃部不适症状，如胃痛、胃灼热感（烧心）、酸性嗳气、饱胀等。西吡氯铵含片：化学制剂。可用于急性咽炎,牙龈炎。【合作方式】扫描底部二维码入驻平台获取产品详细信息无论您是寻找合作伙伴，还是希望推广自己的产品和服务，我们平台都能提供全面的支持。加入我们，让供需对接平台成为您拓展业务、提升竞争力的强有力工具。在这里，每一次连接都可能转化为无限的商机。立即行动，开启您的医药行业新篇章！ END 如需获取更多数据洞察信息或公众号内容合作，请联系医药地理小助手微信号：pharmadl001

2024-07-28

·罗欣药业

罗欣药业注射用头孢哌酮钠舒巴坦钠、蒙脱石散通过仿制药质量和疗效一致性评价

近日，罗欣药业集团股份有限公司（股票代码：002793.SZ，以下简称“罗欣药业”）旗下注射用头孢哌酮钠舒巴坦钠（2.0g）、蒙脱石散（3g、2g、1g）两款产品顺利通过仿制药质量和疗效一致性评价。截止目前，罗欣药业已有24款药物通过仿制药质量和疗效一致性评价。头孢哌酮/舒巴坦的抗菌成分头孢哌酮为第三代头孢菌素，其通过在细菌繁殖期抑制敏感细菌细胞壁粘肽的生物合成而达到杀菌作用。头孢哌酮/舒巴坦复方制剂对所有对头孢哌酮敏感的细菌均具有抗菌活性。另外它对多种细菌，特别是下列细菌均表现出协同抗菌作用，例如：流感嗜血杆菌、拟杆菌属、葡萄球菌属、醋酸钙不动杆菌等。在体外试验中，头孢哌酮/舒巴坦对临床许多重要致病菌具有抗菌活性，例如：革兰阳性菌、革兰阴性菌、厌氧菌。蒙脱石散用于成人急、慢性腹泻，儿童急性腹泻，为天然蒙脱石微粒粉剂，具有层纹状结构和非均匀性电荷分布，对消化道内的病毒、病菌及其产生的毒素、气体等有极强的固定、抑制作用，使其失去致病作用；此外对消化道黏膜还具有很强的覆盖保护能力，修复、提高黏膜屏障对攻击因子的防御功能，具有平衡正常菌群和局部止痛作用。此次两款产品顺利通过仿制药一致性评价，一方面有利于产品提高市场竞争力及占有率，同时也进一步表明罗欣药业在一致性评价产品的研究及仿制药开发领域已经积累了丰富的实践经验，为后续更多产品过评奠定基础。未来，罗欣药业将继续秉持“传递健康”理念，深入实施科技创新，关注未被满足的临床需求，持续推进高质量创新药品研发成果落地，为全球患者提供更多创新药物选择。

一致性评价

2024-07-26

·米内网

【市场】10亿大品种，罗欣过评了

精彩内容 7月25日，罗欣药业发布公告，其下属子公司山东罗欣乐康制药的蒙脱石散一致性评价补充申请获批过评。米内网数据显示，蒙脱石散在2023年中国三大终端六大市场（统计范围见文末）销售规模超过10亿元。此外，其下属子公司山东罗欣药业集团的注射用头孢哌酮钠舒巴坦钠2.0g规格一致性评价补充申请获批过评。蒙脱石散由IPSEN PHARMA研发，用于成人急、慢性腹泻，儿童急性腹泻。近年中国零售药店终端蒙脱石散销售情况（单位：亿元）来源：米内网格局数据库蒙脱石散在2023年中国三大终端六大市场销售规模超过10亿元，其中，院外市场（零售药店终端：城市实体药店+网上药店）是主力销售渠道，同比增长超过60%，是止泻药、肠道抗炎/抗感染药TOP2产品，法国益普生的市场份额最大。米内网数据显示，蒙脱石散有44家企业拥有生产批文，山东罗欣乐康制药、湖南方盛制药、扬子江药业集团等35家企业过评，暂无一致性评价补充申请在审，福建太平洋制药、四川依科制药等5家企业以仿制4类报产在审，获批后视同过评。罗欣药业消化系统及代谢药过评情况来源：米内网一致性评价数据库截至目前，罗欣药业在消化系统及代谢药领域已有11款产品通过/视同通过一致性评价。注射用奥美拉唑钠、奥美拉唑肠溶胶囊、艾司奥美拉唑镁肠溶片等4款产品在2023年中国三大终端六大市场均是10亿级别的大品种。资料来源：公司公告、米内网数据库注：米内网《中国三大终端六大市场药品竞争格局》，统计范围是：城市公立医院和县级公立医院、城市社区中心和乡镇卫生院、城市实体药店和网上药店，不含民营医院、私人诊所、村卫生室，不含县乡村药店；上述销售额以产品在终端的平均零售价计算。如有疏漏，欢迎指正！本文为原创稿件，转载请注明来源和作者，否则将追究侵权责任。投稿及报料请发邮件到872470254@qq.com稿件要求详询米内微信首页菜单栏商务及内容合作可联系QQ：412539092 【分享、点赞、在看】点一点不失联哦

一致性评价