预约演示
更新于：2026-09-09
Eniluracil
恩尿嘧啶
更新于：2026-09-09
概要
基本信息
原研机构 |
最高研发阶段临床2期 |
首次获批日期- |
最高研发阶段(中国)- |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C6H4N2O2 |
InChIKeyJOZGNYDSEBIJDH-UHFFFAOYSA-N |
CAS号59989-18-3 |
关联
13
项与 恩尿嘧啶 相关的临床试验NCT06568692
A Phase 2, Open-Label Study of PCS6422 With Capecitabine in Patients With Advanced or Metastatic Breast Cancer
NCT04861987
A Phase 1b Dose-escalation Study of the Safety and Pharmacokinetics of Fixed-dose PCS6422 with Escalating Doses of Capecitabine Administered Orally to Patients with Advanced, Refractory Gastrointestinal Tract Tumors
NCT01231802
A Comparative, Multicenter, Open-Label, Randomized, Phase 2 Study of the Safety and Antitumor Activity of Oral Eniluracil + 5 Fluorouracil + Leucovorin Versus Capecitabine Monotherapy in Subjects With Metastatic Breast Cancer
100 项与 恩尿嘧啶 相关的临床结果
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100 项与 恩尿嘧啶 相关的转化医学
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100 项与 恩尿嘧啶 相关的专利（医药）
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162
项与 恩尿嘧啶 相关的文献（医药）2024-12-01Sustainable Chemistry and Pharmacy
A silica gel-supported schiff base palladium nanocatalyst for sonogashira cross-coupling and synthesis of an anti-cancer chemotherapeutic agent
作者: O'Reilly, Emmet J. ; Sarkar, Shaheen M. ; Khan, Maksudur Rahman Md. ; Hasan, Kamrul ; Rahman, Lutfor Md
This work outlines the synthesis of a low-cost reusable silica gel-supported Schiff-base palladium nanocatalyst and its application in the synthesis of anti-cancer agent Eniuracil via the Sonogashira reaction.Silica gel was functionalized with amino containing silyl followed by the generation of a Schiff base through reaction with 1,10-phenanthroline-2,9-dicarboxaldehyde.Palladium was then coupled in the presence of hydrazine hydrate, resulting in the formation of the silica gel-supported Schiff-base palladium nanocatalys.Successful palladium incorporation was confirmed through Fourier-transform IR spectroscopy (FTIR) and X-ray diffraction (XRD) analyses.Scanning Electron Microscope (SEM) images revealed spherical silica gel particles and Transmission Electron Microscopy (TEM) anal. indicated an average palladium nanoparticle size of 5.92 ± 0.1 nm.The Inductively Coupled Plasma (ICP) and Energy Dispersive X-ray (EDX) data confirmed the anchoring of 0.27 mol% of palladium to the Schiff-base in the catalyst.The industrial efficacy of the catalysts is demonstrated through its application in carbon-to-carbon bond formation between aryl halides and aromatic alkyne via the Sonogashira reaction.Furthermore, the catalyst proved effective in the synthesis of the anti-cancer agent Eniuracil, a vital component in fluoropyrimidine-based chemotherapy.The catalyst exhibited reusability without significant loss of productivity.
2023-05-01JOURNAL OF MOLECULAR LIQUIDS
Adsorption of 40 low molecular weight drugs on pristine and fluorinated C60 fullerenes: Ab initio, statistical and neural networks analysis
作者: Yusupbek A. Bauetdinov ; Mikhail M. Maslov ; Elizaveta B. Kalika ; Konstantin P. Katin ; Anastasiya A. Grekova ; Nikolay V. Bondarev ; Savas Kaya ; Alexey I. Kochaev
Loading of 40 small drugs mols. with mol. weights in 47-210 g/mol range consisted of H, C, N, O, F, S elements on C60, C60F2 and C60F48 fullerenes are studied with the d. functional theory.Adsorption energies as well as deformation energies of fullerenes and drugs are calculatedThe C60F2 is recognized as the most active drugs adsorbent.Mean adsorption energies averaged over all considered drugs are 0.41, 0.59 and 0.54 eV with standard deviations of 0.10, 0.09 and 0.14 eV for C60, C60F2 and C60F48 fullerenes, resp.Mean energies of drug-induced deformations of C60, C60F2 and C60F48 are 8.6, 12.0 and 16.6 meV, resp.Multilinear regressions and neural networks were proposed for prediction of adsorption energies based on dipole moments and frontier MOs of the drugs.Achievable accuracy of such predictions is about 0.1 eV.Altretamine antibiotic is recognized as the notable drug possessing extremely high binding energies about 1 eV with fullerenes.IR spectral shifts due to its loading on fullerene carriers are calculated
2022-08-01ACS Sustainable Chemistry & Engineering
Designing a Green Replacement for the Lindlar Catalyst for Alkyne Semi-hydrogenation Using Silica-Supported Nickel Nanoparticles Modified by N-Doped Carbon
作者: Bartling, Stephan ; Lund, Henrik ; Bonrath, Werner ; Beller, Matthias ; McNeice, Peter ; Medlock, Jonathan ; Müller, Marc-André ; Junge, Kathrin ; Rockstroh, Nils
A lead- and palladium-free alternative to the Lindlar catalyst has been developed for industrially relevant alkyne semi-hydrogenation using silica-supported nickel nanoparticles modified by nitrogen-doped carbon.The optimal nickel catalyst acts under mild conditions (5 bar H2, 100°C, and 4 h) for the selective semi-hydrogenation of a range of alkynes, including vitamin precursors that are important food supplements.Notably, this novel catalyst is selective for alkynes in the presence of easily reducible groups such as carbonyl and nitrile, which also makes it attractive for other synthetic applications.
56
项与 恩尿嘧啶 相关的新闻（医药）2026-03-18
·上海起发
CSCO会议诊断试剂临床研究
100 项与 恩尿嘧啶 相关的药物交易
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研发状态
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 晚期结直肠腺癌 | 临床3期 | 美国 | 1999-04-01 | |
| 直肠腺癌 | 临床3期 | 美国 | 1999-04-01 | |
| 复发性结肠癌 | 临床3期 | 美国 | 1999-04-01 | |
| 结直肠癌 | 临床3期 | 美国 | - | |
| 结直肠癌 | 临床3期 | 英国 | - | |
| 胰腺癌 | 临床3期 | 英国 | - | |
| HER2 阴性乳腺癌 | 临床2期 | 美国 | 2024-10-02 | |
| 三阴性乳腺癌 | 临床2期 | 美国 | 2024-10-02 | |
| 转移性乳腺癌 | 临床2期 | 美国 | 2011-04-01 | |
| 转移性乳腺癌 | 临床2期 | 俄罗斯 | 2011-04-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床1期 | 18 | 艱醖壓顧願築繭積構製(餘膚積壓遞獵餘襯簾遞) = 36.4% of the patients in the 150 mg BID and 225 mg BID cohorts had grade 3-4 adverse events (AEs) associated with anabolites, similar to the incidence reported for Mono-Cap 範淵鬱艱艱鹹積獵鹹觸 (夢簾鹹夢憲鏇醖廠觸鑰 ) 更多 | 积极 | 2025-05-30 | |||
临床1期 | 12 | 鑰艱構顧築齋鏇選鏇構(蓋觸鬱鹽鏇範廠襯獵夢) = 壓廠鑰艱蓋築襯蓋顧積 積鹽願襯膚衊鹹網齋積 (憲憲餘膚衊淵網夢繭觸 ) 更多 | 积极 | 2024-06-11 | |||
AACR2024 人工标引  | 临床1期 | 18 | NGC-Cap (150 mg bid) | 餘顧積簾簾範鹹鏇鏇襯(廠糧醖獵築廠觸衊鑰製) = 遞窪築襯膚遞膚夢選選 遞鹽蓋齋鑰衊網衊鏇鏇 (構壓鏇齋鏇蓋鹽憲壓鏇, 23) 更多 | 积极 | 2024-04-05 | |
NGC-Cap (225 mg bid) | 餘顧積簾簾範鹹鏇鏇襯(廠糧醖獵築廠觸衊鑰製) = 觸糧鹽鑰選憲選糧願淵 遞鹽蓋齋鑰衊網衊鏇鏇 (構壓鏇齋鏇蓋鹽憲壓鏇, 37) 更多 | ||||||
临床1期 | - | 鹽獵積襯糧簾鏇衊鹹獵(鑰醖餘廠願壓簾鏇簾鹽) = the side effect profile for 5-FU exposures from NGC-Cap had a similar anabolite side effect profile to FDA-approved capecitabine.
In addition, the side effects associated with FBAL (fluoro-beta-alanine, the primary catabolite formed from the metabolism of 5-FU), such as hand-foot syndrome, that can lead to capecitabine intolerance, were almost non-existent, likely because FBAL exposure was approximately 1% of the exposure seen after FDA-approved capecitabine administration. 鹽製觸顧鹹築願餘遞網 (壓齋製蓋夢艱膚鑰憲願 ) | 积极 | 2023-12-19 | |||
临床1期 | - | 5 | 選醖觸鹽窪鏇繭築齋簾(網選膚廠鏇齋夢壓蓋範) = 膚襯獵獵築製願廠窪蓋 積醖淵構願網簾觸顧鬱 (觸淵糧鏇壓遞顧鏇醖壓, 11) | - | 2007-06-20 | ||
临床2期 | 75 | 膚蓋襯製簾壓鑰膚窪憲(餘鬱鬱齋顧壓觸網餘艱) = 顧繭選窪醖艱壓餘廠鹹 範淵膚憲衊遞網範醖艱 (淵糧襯餘觸願遞顧廠齋 ) | 不佳 | 2002-11-01 |
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