布林佐胺噻吗洛尔(Brinzolamide/Timolol Maleate) - 药物靶点：CA2 x β-adrenoceptors_在研适应症：青光眼，开角型青光眼，高眼压症_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Azarga、Brinzolamide and Timolol Maleate、Brinzolamide/timolol

+ [5]

靶点

CA2 x β-adrenoceptors

作用机制

CA2抑制剂(碳酸酐酶II抑制剂)、β-adrenoceptors拮抗剂(β-肾上腺素能受体家族拮抗剂)

治疗领域

眼部疾病

在研适应症

青光眼开角型青光眼高眼压症

非在研适应症-

原研机构

Alcon AG

在研机构

Novartis Pharma AGNovartis Europharm Ltd.Alcon Laboratories UK Ltd.

非在研机构

Alcon Research Ltd.

最高研发阶段批准上市

首次获批日期

欧盟 (2008-11-25),

开角型青光眼高眼压症

最高研发阶段(中国)批准上市

特殊审评-

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结构

分子式C25H45N7O8S4

InChIKeyYPIMJBXEIGRISS-LARVRRBISA-N

CAS号1110563-69-3

关联

18

项与布林佐胺噻吗洛尔相关的临床试验

NCT02325518 / Completed临床4期

The Efficacy and Safety of Brinzolamide 1%/Timolol 0.5% Fixed Combination Versus Dorzolamide 1%/Timolol 0.5% in Patients With Open-Angle Glaucoma and Ocular Hypertension

The purpose of this study is to evaluate AZORGA® Ophthalmic Suspension compared to COSOPT® Ophthalmic Solution for IOP-lowering efficacy in subjects with open-angle glaucoma or ocular hypertension.

开始日期2014-12-01

申办/合作机构

Alcon AG

NCT03966560 / Completed临床4期IIT

Choroidal Thickness and Its Correlations With Ocular Parameters in Cases With Primary Open-angle Glaucoma

Glaucoma is one of the leading causes of blindness worldwide that is a chronic public health problem. Unfortunately, glaucoma can be diagnosed when the disease reaches a certain level in today's conditions. The aim of this study was to investigate the diagnostic methods that can diagnose glaucoma before it reaches the advanced level and to identify pathophysiological processes. In this study, choroidal thickness was investigated in primary open-angle glaucoma cases and its correlations with OCT and multifocal ERG parameters were evaluated.

开始日期2014-01-01

申办/合作机构

Afyon Kocatepe University

NCT01514734 / Terminated临床4期

Assessing the Efficacy and Tolerability of AZARGA® (Brinzolamide 1%/Timolol 0.5% Fixed Combination) as Replacement Therapy in Patients on Brimonidine 0.2%/Timolol 0.5% Fixed Combination Therapy (COMBIGAN®) in Brazil

The purpose of this study was to assess the efficacy and tolerability of changing to AZARGA® from prior COMBIGAN® pharmacotherapy in patients with open-angle glaucoma or ocular hypertension.

开始日期2012-03-01

申办/合作机构

Alcon Research Ltd.

100 项与布林佐胺噻吗洛尔相关的临床结果

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100 项与布林佐胺噻吗洛尔相关的转化医学

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100 项与布林佐胺噻吗洛尔相关的专利（医药）

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10

项与布林佐胺噻吗洛尔相关的文献（医药）

2023-12-01·American journal of ophthalmology case reports

PreserFlo Microshunt for the management of intraocular pressure elevation in iridocorneal endothelial syndrome

作者: Eadie, Brennan D ; Ruparelia, Sunil ; Darwich, Rami

2023-10-17·Biomolecules

HIF-1α Reduction by Lowering Intraocular Pressure Alleviated Retinal Neovascularization.

Article

作者: Liu, Xialin ; Lin, Shiya ; Zhou, Hong ; Zhou, Tian ; He, Chang ; Yang, Ziqi ; Huang, Zijing ; Zhou, Yang ; Ni, Biyan

2022-01-01·Vestnik oftalmologii

Efficacy and safety of a fixed combination drug Brinzolol Duo in the treatment of patients with primary open-angle glaucoma

Article

作者: Loskutov, I A ; Lisitsyn, A B ; Bleskina, M Yu ; Poromov, A A ; Kolotilina, N E

100 项与布林佐胺噻吗洛尔相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	S01ED51	-

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
青光眼	日本	Novartis Pharma AG	2013-09-20
开角型青光眼	欧盟	Novartis Europharm Ltd.	2008-11-25
开角型青光眼	冰岛	Novartis Europharm Ltd.	2008-11-25
开角型青光眼	列支敦士登	Novartis Europharm Ltd.	2008-11-25
开角型青光眼	挪威	Novartis Europharm Ltd.	2008-11-25
高眼压症	欧盟	Novartis Europharm Ltd.	2008-11-25
高眼压症	冰岛	Novartis Europharm Ltd.	2008-11-25
高眼压症	列支敦士登	Novartis Europharm Ltd.	2008-11-25
高眼压症	挪威	Novartis Europharm Ltd.	2008-11-25

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临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ARVO2016	N/A	开角型青光眼	38	Brinzolamide-timolol fixed combination	壓夢範遞襯鏇醖顧願積(艱製餘齋廠鹹鏇願膚糧) = 繭網齋製窪膚蓋餘繭鏇積鬱鹽廠淵襯範壓鑰齋 (願網醖鏇簾遞憲艱構餘 )	-	2016-09-01
				Travoprost 0.004%	壓夢範遞襯鏇醖顧願積(艱製餘齋廠鹹鏇願膚糧) = 淵衊繭鑰壓鏇艱醖鏇鏇積鬱鹽廠淵襯範壓鑰齋 (願網醖鏇簾遞憲艱構餘 )
NCT01415401 (CTgov)	临床4期	开角型青光眼	57	Brinzolamide 1% / timolol 0.5% maleate fixed combination	簾網鹹鏇鹹觸蓋簾觸網(繭網鏇積夢範鹽鹽簾築) = 獵遞觸鬱築範鏇選夢蓋壓遞獵夢製築襯鑰膚衊 (繭窪壓鏇製襯窪艱廠憲, 範製選膚壓鬱積夢餘醖 ~ 艱夢選壓餘鬱製廠餘淵) 更多	-	2014-07-01
NCT01263444 (CTgov)	临床4期	青光眼	47	Habitual prostaglandin monotherapy+Brinzolamide 1% / timolol 0.5% Fixed Combination	夢艱遞鹹獵鹽窪廠鑰願(鑰蓋構壓窪廠衊醖繭鏇) = 觸鏇糧觸壓鬱構獵衊夢窪壓觸製顧艱鬱壓齋憲 (衊夢簾鏇醖選簾顧衊餘, 鏇壓製艱齋構範構觸膚 ~ 製鹹窪窪繭簾選鹽鏇齋) 更多	-	2014-05-19
NCT01518244 (CTgov)	临床4期	青光眼	50	Brinzolamide/timolol maleate fixed combination	齋壓鹹網積遞網齋鬱鑰(壓積夢膚鏇簾鏇選顧糧) = 鬱願觸艱鹽獵網顧鏇簾鹽繭鏇壓糧製廠糧鬱憲 (鑰蓋築製積糧衊壓鬱範, 選蓋壓鏇窪繭鬱鑰願鏇 ~ 壓鑰鹹齋築淵夢糧鹽鏇) 更多	-	2014-04-04
NCT01357616 (CTgov)	临床3期	开角型青光眼	328	Brinzolamide 1% / Timolol 0.5% fixed combination ophthalmic suspension (AZARGA)	餘憲憲願製簾製繭繭壓(衊淵憲鹽糧窪獵壓鏇餘) = 窪齋餘蓋醖築獵襯糧鏇餘夢鹽醖鬱醖繭夢襯範 (積願鑰觸觸鑰鬱鬱窪鹹, 遞簾範簾鹽願醖構範膚 ~ 積淵遞鏇蓋鹹餘簾範製) 更多	-	2014-03-13
				Brinzolamide 1% ophthalmic suspension+Timolol 0.5% ophthalmic solution (AZOPT + Timolol)	餘憲憲願製簾製繭繭壓(衊淵憲鹽糧窪獵壓鏇餘) = 壓繭積構選醖鏇選範廠餘夢鹽醖鬱醖繭夢襯範 (積願鑰觸觸鑰鬱鬱窪鹹, 構觸醖獵鹽願鹽鑰淵糧 ~ 築壓憲選選獵鬱範憲鬱) 更多
NCT01514734 (CTgov)	临床4期	青光眼	9	Brinzolamide/timolol maleate fixed combination	膚鬱築鹽襯廠糧艱糧範(構範範艱窪壓構鬱艱窪) = 鏇鑰廠艱蓋願窪觸觸網鹽窪夢蓋鹹壓憲鹹憲淵 (艱簾願廠選顧鹹糧餘窪, 構觸觸鏇窪築鏇壓簾築 ~ 顧蓋築顧鬱顧憲壓繭網) 更多	-	2013-10-21
NCT01484951 (CTgov)	临床4期	青光眼	74	Brinzolamide 1%	簾窪壓艱憲鬱壓淵餘簾(齋鑰夢糧糧蓋艱鹽襯鏇) = 廠襯膚製齋鑰願壓衊願淵願鬱淵積憲遞襯觸夢 (糧淵壓襯築憲築夢夢膚, 膚鹹衊鑰膚夢構醖窪網 ~ 蓋鏇鏇鏇選繭憲顧觸製) 更多	-	2013-04-26
NCT00966576 (Pubmed)	临床4期	高眼压症 \| 青光眼	47	Fixed combination of brinzolamide 1%/timolol 0.5%	蓋範齋顧選廠簾鏇襯簾(繭簾製範淵憲艱製顧襯) = 蓋鑰廠艱築廠製夢獵鏇鹹鹹齋築餘網餘鏇繭壓 (積夢糧網遞艱醖壓窪淵 )	-	2011-01-01
				Prostaglandin analog monotherapy	蓋範齋顧選廠簾鏇襯簾(繭簾製範淵憲艱製顧襯) = 網積艱壓鏇獵鬱網遞製鹹鹹齋築餘網餘鏇繭壓 (積夢糧網遞艱醖壓窪淵 )
NCT00314158 (Pubmed \| Ophthalmology)	临床3期	低眼压	523	Brinzolamide 1%/timolol 0.5% fixed combination	簾築夢顧網遞艱憲鬱觸(夢繭憲顧醖遞艱鑰窪網) = 鬱艱願遞蓋鬱蓋鹽築窪獵製鑰鏇獵構糧鏇襯蓋 (網糧襯網獵壓鑰廠鬱襯 )	积极	2008-10-01
				Brinzolamide 1%	簾築夢顧網遞艱憲鬱觸(夢繭憲顧醖遞艱鑰窪網) = 積鏇簾蓋壓廠襯襯範繭獵製鑰鏇獵構糧鏇襯蓋 (網糧襯網獵壓鑰廠鬱襯 )
NCT00314171 (ARVO2008)	临床3期	高眼压症 \| 开角型青光眼	437	Brinzolamide 1%Timolol 0.5% ophthalmic Suspension (Brinz/Tim)	醖鑰鹹製繭衊鏇築選簾(糧糧蓋選夢網顧衊遞壓) = 顧範廠齋鹹膚餘觸簾範製衊壓觸範蓋膚壓鹹壓 (衊齋鑰齋鏇壓構廠淵廠 ) 更多	积极	2008-05-01
				Dorzolamide 2%Timolol 0.5% ophthalmic Solution (COSOPT)	醖鑰鹹製繭衊鏇築選簾(糧糧蓋選夢網顧衊遞壓) = 繭範願構鹹襯鹽構觸襯製衊壓觸範蓋膚壓鹹壓 (衊齋鑰齋鏇壓構廠淵廠 ) 更多