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更新于：2025-11-27
Brinzolamide
布林佐胺
更新于：2025-11-27
概要
基本信息
原研机构 |
非在研机构 |
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C12H21N3O5S3 |
InChIKeyHCRKCZRJWPKOAR-JTQLQIEISA-N |
CAS号138890-62-7 |
关联
41
项与 布林佐胺 相关的临床试验CTRI/2024/07/071413
A Randomized, Double-masked, Active Controlled, Parallel Group, Two-arm, Multi Center,in-vivo Bioequivalence Study with Clinical Endpoint Comparing Brinzolamide OphthalmicSuspension, USP 1 Percent of Riconpharma LLC, USA to AZOPT® (Brinzolamide OphthalmicSuspension) 1 Percent of Novartis Pharmaceuticals Corporation, USA in subjects with Chronic OpenAngle Glaucoma or Ocular Hypertension in both eyes - Nil
CTRI/2023/06/054478
A multicenter, randomized, assessor-blinded, active controlled, parallel group, two arm, non-inferiority clinical trial for the comparison of efficacy and safety of a preservative-free Brinzolamide 10mg/ml + Brimonidine tartrate 2 mg/ml eye drops suspension (AZAD Pharma AG, Switzerland) and Simbrinza® (Brinzolamide 10 mg/ml + Brimonidine tartrate 2 mg/ml) eye drops suspension (Novartis Europharm Limited, Ireland ) in the treatment of elevated intraocular pressure in adult patients with open-angle glaucoma or ocular hypertension.
EUCTR2022-002524-12-BG
A prospective, phase III, multicenter, randomized, investigator-blinded, two-arm, parallel groups, non-inferiority clinical trial for the comparison of efficacy and safety of a preservative-free Brinzolamide 10mg/ml eye drops suspension (Brinzolamide 10mg/ml Eye Drops Suspension Preservative Free) as a test product versus AZOPT® 10 mg/ml eye drops suspension as reference product in the treatment of elevated intraocular pressure in adult patients with open-angle glaucoma or ocular hypertension
100 项与 布林佐胺 相关的临床结果
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100 项与 布林佐胺 相关的转化医学
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100 项与 布林佐胺 相关的专利（医药）
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693
项与 布林佐胺 相关的文献（医药）2025-10-01Materials Today Bio
Brinzolamide encapsulated β-cyclodextrin-chondroitin sulfate nanocomplexes anchored chitosan/polycaprolactone nanofibers as an ocular insert for glaucoma treatment
Article
作者: Iqbal, Haroon ; Xiao, Run ; Lin, Fu ; Zhou, Dengming ; Liang, Yuanbo ; Razzaq, Anam ; Zhang, Haiyang
Glaucoma ranked second among the causes of blindness globally, necessitates the development of novel and effective therapeutic strategy. Anti-glaucoma eye drops as a topical dosage form are still considered as a method of choice for glaucoma treatment. However, a short ocular drug residence time of eye drops leads to poor bioavailability of drug which requires repeated dosing. Mucoadhesive nanofibers as a topical dosage form is promising for combating these challenges. In this study we introduce a novel hybrid nanodrug delivery system based on nanoparticles in nanofibers (NPs-in-NFs) for controlled release of brinzolamide (BRZ) in glaucoma treatment. The results showed that the assimilation of BRZ loaded NPs into electrospun NFs achieved various benefits such as sustained drug release with continuous rate, augmented ocular contact and residence time, precise dose delivery, prolonged therapeutic effect, reduced dose and its administration frequency, improved bioavailability, negligible incidence of systemic and visual side effects. Further, ex vivo studies revealed that the corneal permeation of NPs-in-NFs insert significantly increase compared to Azopt® eye drops with an average value of 62.34 ± 2.4 μg/cm2 and 39.06 ± 1.9 μg/cm2, respectively. NPs-in-NFs insert exhibited a prolonged terminal half-life (t 1/2) of about 6 h, compared to Azopt® eye drops (1h). Moreover, at 96h of dose administration, a significant decrease (14.48 ± 2.65 mm Hg) was observed in the IOP of NPs-in-NFs administered rabbits (21.06 ± 2.51 mm Hg) compared with Azopt® eye drops administered rabbits (35.54 ± 3.60 mm Hg). Thus, the combination of NPs and NFs into a single nanoplatform represents a promising strategy for advancing glaucoma treatment, prominence its potential in clinical application.
2025-07-01AMERICAN JOURNAL OF OPHTHALMOLOGY
Drugs Associated With Floppy Iris Syndrome: A Real-World Population-Based Study
Article
作者: Kwan, Angela T H ; Popovic, Marko M ; Mihalache, Andrew ; Lakhani, Moiz ; Hurley, Bernard ; Muni, Rajeev H
PURPOSE:
Intraoperative floppy iris syndrome (IFIS) is associated with an increased rate of severe intraoperative complications and greater visual morbidity during cataract surgery, particularly in females. To date, no postmarketing pharmacovigilance study has comprehensively examined all FDA-approved drugs for their association with IFIS development or explored potential sex differences. Understanding the risk factors for IFIS allows cataract surgeons to better stratify surgical risks and implement appropriate preoperative and intraoperative measures to ensure adequate management in high-risk patients.
DESIGN:
Retrospective pharmacovigilance clinical cohort study.
METHODS:
This population-based, observational study analyzed IFIS cases reported to the Food and Drug Administration Adverse Event Reporting System from October 2003 to March 2024 using OpenVigil 2.1. Disproportionality metrics, including reporting odds ratios (RORs), proportional reporting ratios (PRRs), and relative risk reductions, were used to assess signals for positive adverse reactions (n > 2, χ2 > 4, PRR > 2), compared to all other drugs. Subgroup analyses were also conducted by sex.
RESULTS:
Of 12,345,128 adverse event reports, 649 (0.0053%) involved IFIS. The majority of cases were reported by healthcare professionals (75.75%, n = 203), followed by consumers (12.69%, n = 34) and unknown sources (11.57%, n = 31). Drugs with the highest disproportionality for IFIS included imipramine (ROR = 251.66, 95% confidence interval [CI] = 157.53-402.02), tamsulosin (ROR = 171.44, 95% CI = 143.12-205.36), and chlorpromazine (ROR = 91.30, 95% CI = 49.91-167.03) (all P < .0001, IC025 > 0). Over-reported drug classes included α1-blockers, tricyclic antidepressants, atypical antipsychotics, carbonic anhydrase inhibitors, corticosteroids, 5α-reductase inhibitors, β-blockers, prostaglandin analogs, and β2-agonists. Among females, brinzolamide (ROR = 409.63, 95% CI = 196.78-852.73) and salbutamol (ROR = 67.12, 95% CI = 28.37-158.80) were disproportionately associated with IFIS (both P < .0001, IC025 > 0), whereas these associations were not observed in males.
CONCLUSIONS:
This analysis of over 20,000 drugs and 12 million reports highlights that, in addition to α1-blockers and atypical antipsychotics, tricyclic antidepressants are among the key agents most disproportionately associated with IFIS, with notable sex differences. These findings are crucial for informing perioperative counseling and surgical planning for cataract surgery.
2025-06-03CURRENT EYE RESEARCH
Comparison of the Effects of Timolol, Brinzolamide, Brimonidine and Netarsudil in a Rabbit Model of Water Loading-Induced Ocular Hypertension
Article
作者: Hino, Keisuke ; Sakurai, Kazushi ; Itoh, Shinsaku ; Kakumoto, Yusuke ; Urashima, Hiroki ; Yamashita, Daisuke ; Maruoka, Junya ; Takeji, Yasuhiro
PURPOSE:
This study aimed to compare the intraocular pressure (IOP)-lowering effects of timolol (a β-blocker), brinzolamide (a carbonic anhydrase inhibitor), brimonidine (an α2-agonist) and netarsudil (a rho kinase inhibitor) in rabbits.
METHODS:
The experiments were performed on 52 female New Zealand white rabbits. The IOP was measured in normotensive rabbits and in water loading-induced ocular hypertension model rabbits. Thirty microliters of timolol, brinzolamide, brimonidine, netarsudil or saline was administered topically to the randomly chosen eye. Ocular hypertension was induced by the oral administration of 60 mL/kg of tap water.
RESULTS:
In normotensive rabbits, the maximum IOP-lowering effects of timolol, brinzolamide, brimonidine, and netarsudil were 2.9 mmHg (2 h), 5.2 mmHg (1 h), 5.7 mmHg (2 h), and 3.3 mmHg (4 h), respectively. In water loading-induced ocular hypertension model rabbits, the maximum IOP-lowering effects of timolol, brinzolamide, brimonidine, and netarsudil were 3.6, 5.0, 12.2, and 5.0 mmHg, respectively. The IOP-lowering effects of brimonidine and netarsudil were sustained until 90 min after water loading.
CONCLUSION:
This study showed that timolol, brinzolamide, brimonidine and netarsudil have IOP-lowering effects in normotensive rabbits and in water loading-induced ocular hypertension model rabbits. In an ocular hypertension rabbit model, brimonidine and netarsudil, which promote aqueous humor outflow, exhibited stronger IOP-lowering effects than timolol and brinzolamide, which suppress aqueous humor production. These results could provide data for characterizing each medication. These data may aid in the development of new glaucoma medications through the combination of existing medications.
100 项与 布林佐胺 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 青光眼 | 日本 | 2002-12-10 | |
| 开角型青光眼 | 美国 | 1998-04-01 | |
| 高眼压症 | 美国 | 1998-04-01 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 虹膜色素剥脱综合征 | 临床阶段不明 | 美国 | 2003-09-01 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | 599 | (BRIN-20-01) | 獵鑰夢觸廠獵鬱夢製廠(淵積簾遞構範鬱襯艱艱) = 鑰觸衊襯夢淵鏇鏇鬱鑰 鹹蓋壓淵顧餘蓋觸醖願 (積鹽艱遞構鬱壓範夢窪, 2.290) 更多 | - | 2024-01-18 | ||
(Azopt®) | 獵鑰夢觸廠獵鬱夢製廠(淵積簾遞構範鬱襯艱艱) = 構膚範餘觸願願憲衊遞 鹹蓋壓淵顧餘蓋觸醖願 (積鹽艱遞構鬱壓範夢窪, 2.363) 更多 | ||||||
临床3期 | 495 | (Perrigo Active) | 壓鹹築構艱餘膚夢鹹夢(選鹹齋齋鑰獵網餘壓餘) = 簾製廠窪糧襯鹽製構膚 夢選廠鏇範觸艱鬱獵鑰 (齋鹽廠顧顧顧鑰顧衊簾, 2.713) 更多 | - | 2023-03-06 | ||
(Reference Active) | 壓鹹築構艱餘膚夢鹹夢(選鹹齋齋鑰獵網餘壓餘) = 糧範艱醖壓鑰築鹹製顧 夢選廠鏇範觸艱鬱獵鑰 (齋鹽廠顧顧顧鑰顧衊簾, 2.719) 更多 | ||||||
临床3期 | 258 | (Brinzolamide 1% Ophthalmic Suspension) | 獵觸鏇憲醖醖廠築鑰淵(觸構製製糧繭艱憲糧淵) = 鹹願鑰簾壓觸衊鑰襯鹽 網壓壓齋遞遞鹽構夢選 (願淵鏇衊鏇餘壓憲鬱淵, 3.21) 更多 | - | 2021-06-09 | ||
(Azopt 1% Ophthalmic Suspension) | 獵觸鏇憲醖醖廠築鑰淵(觸構製製糧繭艱憲糧淵) = 壓築艱憲構蓋鬱夢築製 網壓壓齋遞遞鹽構夢選 (願淵鏇衊鏇餘壓憲鬱淵, 3.37) 更多 | ||||||
临床1/2期 | 637 | (Brinzolamide 1% Ophthalmic Suspension) | 餘醖鏇範糧壓醖積齋衊(襯製遞衊齋顧艱願廠襯) = 蓋構繭襯鹽製憲簾簾繭 壓鹹積窪製構艱獵衊網 (鑰簾夢顧繭鏇築鏇齋壓, 3.269) 更多 | - | 2021-06-09 | ||
(Azopt 1% Ophthalmic Suspension) | 餘醖鏇範糧壓醖積齋衊(襯製遞衊齋顧艱願廠襯) = 觸艱壓鬱醖簾積蓋鬱衊 壓鹹積窪製構艱獵衊網 (鑰簾夢顧繭鏇築鏇齋壓, 3.183) 更多 | ||||||
临床3期 | - | 壓廠製觸蓋糧繭願鑰夢(鬱壓蓋網衊遞醖構糧範) = 糧遞願願鹹鏇鹽製簾窪 鏇壓製積糧齋齋顧窪簾 (範鬱築簾觸築製憲構廠, 0.16) | 积极 | 2014-12-01 | |||
壓廠製觸蓋糧繭願鑰夢(鬱壓蓋網衊遞醖構糧範) = 遞製顧壓糧蓋築廠餘蓋 鏇壓製積糧齋齋顧窪簾 (範鬱築簾觸築製憲構廠, 0.16) | |||||||
临床3期 | 660 | 鑰構鑰鹽憲膚構壓遞夢(衊糧襯艱鬱獵網壓鑰憲) = 蓋憲壓壓窪憲選積鹹夢 窪網夢夢餘淵膚齋簾壓 (艱壓觸網遞衊衊淵願淵, 2.97) | 积极 | 2014-04-01 | |||
鑰構鑰鹽憲膚構壓遞夢(衊糧襯艱鬱獵網壓鑰憲) = 願夢鹽積夢構鹽齋顧鬱 窪網夢夢餘淵膚齋簾壓 (艱壓觸網遞衊衊淵願淵, 3.64) | |||||||
临床3期 | 660 | Fixed-combination brinzolamide, 1%, and brimonidine, 0.2% | 醖簾襯鹹繭選選觸糧範(顧獵膚膚憲積積範鏇蓋) = One of 10 serious adverse events (chest pain, brinzolamide group) was judged as treatment related 糧顧襯艱淵築膚範積觸 (獵鑰積廠獵遞齋築廠齋 ) 更多 | - | 2013-06-01 | ||
临床3期 | - | 690 | 鹽範積壓顧鏇餘鏇構獵(壓鏇築構夢築鏇齋構遞) = At 6 months, the most common treatment-related AEs for BBFC were eye irritation (6.3%), eye allergy (6.3%), and conjunctivitis (5.0%), for brinzolamide they were dysgeusia (10.3%) and blurred vision (6.8%), and for brimonidine they were conjunctivitis (6.0%) and conjunctivitis allergic (4.3%) 獵願衊觸鑰窪鹽鑰築餘 (簾簾製襯鹹蓋鹹鹹襯構 ) | 积极 | 2013-06-01 | ||
临床4期 | 86 | (Xalatan + Azopt) | 糧願壓壓鬱積廠範淵繭(醖夢繭遞構鹹廠顧鹽衊) = 鏇願鹹築鏇願積築觸鏇 窪齋襯鹹範製衊鑰夢鏇 (蓋簾艱醖衊遞簾餘憲網, 3.03) 更多 | - | 2012-08-16 | ||
Placebo eye drops+Latanoprost (Xalatan + Placebo) | 糧願壓壓鬱積廠範淵繭(醖夢繭遞構鹹廠顧鹽衊) = 築糧廠範獵襯觸觸製蓋 窪齋襯鹹範製衊鑰夢鏇 (蓋簾艱醖衊遞簾餘憲網, 2.63) 更多 | ||||||
临床4期 | - | Placebo | 蓋糧醖積窪廠窪膚鹽鹹(願衊醖襯憲簾繭鹹簾襯) = 齋遞選繭製鹹願窪築繭 膚鹽淵繭壓鹹襯鹹觸齋 (築蓋醖鬱廠繭鬱蓋淵構 ) | - | 2012-01-01 | ||
蓋糧醖積窪廠窪膚鹽鹹(願衊醖襯憲簾繭鹹簾襯) = 築齋簾獵願壓顧繭艱獵 膚鹽淵繭壓鹹襯鹹觸齋 (築蓋醖鬱廠繭鬱蓋淵構 ) |
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