Canagliflozin Hemihydrate

近年来，随着再生医学技术飞速发展，羊膜干细胞上清液凭借“不含活细胞、却拥有强大修复与抗衰能力”的独特优势，成为科研、临床与高端修护领域备受关注的生物活性物质。 它究竟是什么？从哪里来？如何发挥作用？是否安全有效？产品该如何选择？今天我们用一篇文章，为你系统、清晰、科学地解读。 什么是干细胞上清液？ 干细胞上清液（Stem Cell Culture Supernatant），是指在体外培养干细胞过程中，从细胞培养液中分离出的、不含细胞的上层透明液体。它不含活细胞，但富含干细胞在生长过程中分泌的多种活性因子。这些活性因子，可以促进细胞再生，调节免疫，抑制炎症改善身体的各项机能从而达到治疗的效果。 活性因子： 简单来说，活性因子就是细胞在活动时分泌出来的“有用物质”，它们就像细胞发出的“信号”或“营养包”，能帮助身体修复、抗炎、延缓衰老。常见的活性因子包括细胞因子和生长因子。 细胞因子（Cytokine）是由细胞分泌的低分子蛋白质生理活性物质的总称，也称活性蛋白。其与细胞间的相互作用有关，影响周围细胞。目前为止研究发现了数百种细胞因子，且还在持续发现新的细胞因子。其中有对特定细胞起到促进增殖、分化作用的内在性蛋白，通称“生长因子”。 首先明确干细胞上清液≠干细胞。其实它是在培养人体干细胞时，培养液中会产生丰富的各类生长因子及外泌体等，将干细胞分离后经过杀菌处理得到的高纯度的上部澄清液体（干细胞培养上清液）。 这种液体中富含干细胞释放出的大量细胞因子（IGF、bEGF，NGF、 HGF、VEGF、G-CSF、TGF-β等）。细胞因子又称细胞活素，是细胞分泌的各种生理活性物质的总称。在调节免疫系统机能、恢复细胞活性以及修复受损老化组织的过程中起着重要的作用。干细胞上清液疗法的抗衰作用主要就是靠这些细胞因子修复体内受损的细胞。简单挑选几种细胞因子进行一下介绍～ 主要细胞因子及其作用 β-NGF： 促进生成神经传导物质，保护神经细胞。当细胞出现损伤时，进行修复。促进脑神经功能恢复，预防脑部老化。预防及改善阿尔兹海默症症状。 VEGF：（vascular endothelial growth factor）⾎管内⽪⽣⻓因⼦，可促进血管内皮细胞增殖，血管新生。通过向毛囊输送营养，促进生发。给肌肤提供能量，使得肌肤光泽。通过产生新的细胞，预防、改善皱纹。 HGF： 促进肌肤细胞增殖及细胞运动。抑制细胞凋亡、诱导形态生成、血管新生等。与组织再生相关。 TGF-α： 通过强化胶原蛋白与弹性蛋白结构，增强肌肤弹性。促进肌肤新生及创伤治愈。通过产生新的细胞，预防、改善皱纹。 TGF-β：（transforming growth factor-beta）转化⽣⻓因⼦，可增殖皮肤细胞，同样具备调整新陈代谢的功效。除此之外，其独特魅力效果在于可促进胶原蛋白新生。 EGF：（epidermal growth factor）表⽪⽣⻓因⼦，由53个单氨基酸构成的生长因子，也是蛋白质的一种，存活于唾液、皮肤、母乳等我们身体的各个部位。EGF受容体存在于我们的皮肤中，发挥作用时会带来皮肤活性化，由此带来良好的新陈代谢。通过产生新的皮肤细胞，预防、缓解皱纹。促进伤口恢复。使肌肤嫩滑富有光泽。健康肤色。 PDGF： 促进受损皮肤细胞再生。促进产生胶原蛋白，改善皱纹。促进生发。 IGF-1：（insulin like growth factor-1）类胰岛素⼀号增⻓因⼦，有利于细胞生长与发育，对皮肤发挥良好功效，对毛发也同样起效。通过产生新的皮肤细胞，预防、缓解皱纹，提升肤质，燃烧面部及身体多余脂肪。刺激毛囊，强韧毛发。 不同来源的干细胞及其差异性： 干细胞广泛存在于身体各个部分，用于再生医疗培养增殖的干细胞主要有4种来源，即脂肪、脐带、牙髓、羊膜。这些不同来源的干细胞，所衍生的干细胞上清液在功效及特性上也存在差异。下面就此为大家介绍： 牙髓来源干细胞上清液 牙髓由来干细胞上清液是由人体牙齿神经（牙髓细胞）生成的培养上清液。尽管下至婴儿上至老者都有着牙髓细胞，但更年轻的牙髓细胞含有更多的生长因子。因此再生医疗相关产品应用的都是儿童乳牙。牙髓细胞被坚硬的牙釉质包裹，因此不易受到癌细胞侵袭等来自外部的不良影响，可以采集到品质优良的干细胞。牙髓来源干细胞还有一大特点是，不仅含有生长因子、还富含外泌体成分。 牙髓来源干细胞上清液主要功效： 1）增强视力 2）改善男性功能（ED） 3）缓解疲劳 4）针对自律神经失调进行改善 5）缓解腰痛关节痛、手脚麻痹、肩膀酸痛 6）改善睡眠 脐带由来干细胞上清液 脐带由来干细胞上清液是使用从脐带处采集的干细胞所生成的培养上清液。脐带在分娩时连接着婴儿和母体，其内部含有多种营养物质。脐带来源干细胞的特点是含有大量细胞因子。 脐带由来干细胞培养上清液主要针对以下症状进行改善： 1）脊髓损伤、多发硬化、帕金森等 2）骨质疏松、骨骼缺损、风湿关节炎症 3）心脏病、糖尿病、糖尿病性肾病、肝硬化、慢性肝炎、间质性肺炎 4）再生不良性贫血、白血病 5）过敏性皮炎、脱发等 脂肪由来干细胞上清液 脂肪由来干细胞上清液是由人体脂肪组织产生的培养上清液。通常使用微创抽脂术提取脂肪。其富含对肝脏有益的生长因子HGF，与包括肝脏在内的内脏细胞之间存在有很强的亲和力。还有益于头发和皮肤相关问题的治疗及改善。 脂肪由来干细胞上清液主要功效如下： 1）改善男性脱发（AGA） 2）改善女性头发稀疏问题 3）改善肝脏功能 4）对皱纹、松弛等肌肤问题起到改善作用 羊膜由来干细胞上清液 羊膜由来干细胞上清液是由羊膜产生的培养上清液，羊膜是指位于子宫和胎盘最内层的半透明薄膜。保护胎儿发育的羊膜所提取的干细胞具有极强的再生能力，特别有助于保持肌肤弹性和滋润、恢复皮肤年轻态效果显著。此外也有改善皮肤松弛的效果。还具有抗炎作用。 什么是羊膜干细胞上清液？ 羊膜干细胞上清液，是从健康人羊膜干细胞在标准化培养过程中，收集、纯化、过滤后得到的无细胞生物活性制剂。 简单理解： 它不含活细胞，但保留了干细胞分泌的全部“修复精华” 包括外泌体、 多种生长因子、 细胞因子、多肽、小分子RNA等数百种活性物质。 旁分泌作用：这是它促进组织修复的核心方式。它能分泌：   · VEGF、HGF：促进血管新生，改善局部血供。   · BDNF、NGF：营养神经，促进神经轴突生长。   · KGF：促进皮肤上皮细胞增殖，实现创面无瘢痕愈合。 它的核心价值在于： 继承干细胞的修复能力，同时避开细胞使用的限制，更安全、更稳定、更易应用。 来源：来自胎盘最内层的天然修护组织 羊膜干细胞上清液的源头，是胎盘羊膜组织。 - 取自健康足月、顺产胎盘的最内层薄膜 - 属于医疗废弃物再利用，无胚胎伦理问题 - 经过严格的传染病筛查、健康筛查 - 免疫原性极低，不易引起排异与过敏 - 在GMP标准车间制备、纯化、除菌、检测 正因来源纯净、制备规范，羊膜干细胞上清液成为目前生物相容性最好、安全性最高的再生医学原料之一。  作用机制： 它为什么能实现抗炎修护？ 羊膜干细胞上清液的效果，不是“概念”，而是建立在清晰的生物学机制之上。 1. 抗炎与微环境稳定原理 通过抑制炎症信号通路、中和促炎因子，降低组织局部过度炎症反应，减少氧化应激损伤，重建稳定的细胞生存微环境，为修复提供基础条件。 它不仅能抑制T淋巴细胞活化，更能诱导生成调节性T细胞（Treg），从根源上重建免疫耐受。同时，它分泌的IL-10和TSG-6等抗炎因子，能有效抑制哮喘、关节炎等疾病中过度的炎症反应。 2. 细胞增殖与组织再生原理 上清液中的生长因子、多肽等活性成分，可与细胞膜受体结合，启动细胞增殖、迁移与分化信号，促进成纤维细胞活化、胶原合成与上皮组织再生，实现结构层面的修复。 3. 免疫调节原理 依托羊膜来源的天然低免疫原性，以及上清液中免疫调节因子的作用，平衡局部免疫应答，减少敏感、应激与异常反应，提升组织相容性与自愈能力。 4. 抗衰与细胞保护原理 通过调控细胞衰老通路、保护线粒体功能、减少细胞凋亡，延长细胞健康生命周期，延缓细胞老化与功能衰退，从根源维持组织年轻状态。 以上四大核心原理协同作用，使羊膜干细胞上清液具备稳定、温和、长效的修复与抗衰生物学基础。  实际应用与效果： 覆盖多场景的修护力 羊膜干细胞上清液的应用范围广泛，且效果均有科学支撑： ✔ 肌肤抗衰与屏障修护 - 改善细纹、松弛、粗糙、光老化 - 修复敏感肌、泛红、干燥、屏障脆弱 - 提亮肤色，增加皮肤细腻度与弹性 ✔ 创面愈合与减少疤痕 - 加速伤口、微创后修复 - 促进胶原有序排列，减少疤痕增生 ✔ 眼部与黏膜修护 - 改善眼表干燥、脆弱 - 支持黏膜组织修复与稳定 ✔ 身体机能与内源抗衰 - 支持细胞年轻化 - 改善慢性炎症相关状态 产品选择 这款超级干细胞羊膜上清液，以天然免疫豁免、高活性、低免疫原的安全特性，集强效抗炎、组织修复、疤痕改善、黏膜修护、抗衰紧致、抗氧化抗糖化于一体，是再生医学级抗炎修护的王牌选择。 核心突出功效 1. 强大抗炎与免疫调节 依托羊膜天然免疫豁免特性，可有效抑制炎症因子，调节免疫，减轻红肿热痛，舒缓泛红敏感，改善慢性炎症与过敏体质。 2. 优异组织愈合与疤痕修复 促进上皮细胞再生，加速创面愈合；同时抑制过度纤维增生，减少疤痕形成，适合术后修复、烧伤、溃疡及皮肤屏障受损修复。 3. 角膜与黏膜修护 对角膜、黏膜等脆弱组织具有高度亲和性，在干眼症、角膜损伤、妇科黏膜修复等领域具备扎实研究基础与应用优势。 4. 抗纤维化与防粘连 可抑制组织异常纤维化，预防术后组织粘连，对肺纤维化等问题也具备一定应用潜力。 5. 全层抗衰紧致 激活成纤维细胞，促胶原/弹性蛋白生成，淡纹、提亮、收紧、细腻肤质。 6. 促血管新生+微循环改善 提升营养输送与代谢，改善暗沉、倦容、局部供血不足。 7. 抗氧化+抗糖化 清除自由基，延缓细胞老化，改善黄气、粗糙、松弛。 主要应用场景 - 日常抗衰、改善慢性炎症 - 敏感肌修复、泛红维稳 - 特应性皮炎等炎症性肌肤护理 - 医美术后抗炎、舒缓、修复 - 眼部护理：干眼、眼表损伤修护 - 慢性伤口、黏膜溃疡愈合护理 - 疤痕改善、防粘连、抗纤维化护理 应用案例 01 神经系统疾病：脑瘫与脊髓损伤  · 机制：通过旁分泌作用唤醒受损但未完全坏死的神经细胞，促进神经网络重建。 · 案例：在治疗早产儿脑白质损伤的临床研究中，接受羊膜干细胞鞘内注射的患儿，在运动功能和认知能力评分上，显著优于常规康复组。在脊髓损伤领域，有案例显示患者的感觉和大小便功能得到改善。 02 自身免疫病：难治性系统性红斑狼疮 · 机制：重置紊乱的免疫系统，抑制攻击自身组织的抗体。 · 案例：一项涉及数十例对传统药物耐药患者的临床试验中，接受羊膜干细胞移植后，总生存率显著提升，病情完全缓解率超过50%。患者的蛋白尿消失，抗ds-DNA抗体滴度下降，补体水平回升。 03 妇科和生殖医学：反复种植失败与卵巢早衰、修复改善子宫内膜炎症 · 机制：修复因机械损伤或感染导致的子宫内膜变薄，改善胚胎着床的“土壤”；同时分化为卵巢颗粒细胞，恢复卵巢功能。 ⽺膜⼲细胞可分化为⼦宫内膜上⽪细胞，补充受损的内膜组织，抑制⼦宫内膜局部的炎症反应，减少炎性细胞浸润，缓解⼦宫内膜充⾎、⽔肿等炎症表现。调节⼦宫局部免疫微环境，降低异常免疫反应对⼦宫内膜的持续损伤，尤其适⽤于⾃身免疫相关的慢性⼦宫内膜炎。 · 案例：在宫腔粘连患者中，通过宫腔镜下将羊膜干细胞移植到内膜后，子宫内膜厚度从平均4mm增加至8mm以上，并有多名患者成功分娩。在卵巢早衰领域，部分患者在接受干细胞卵巢局部注射后恢复月经，并自然受孕。 04 眼科：角膜缘干细胞缺乏症 · 机制：利用羊膜的天然透明特性和抗炎能力，作为培养干细胞的理想载体。移植后能重建健康的角膜上皮，恢复透明度和视力。 · 案例：对于化学烧伤导致的角膜损伤，采用“羊膜负载干细胞”移植后，多数患者视力明显提升，眼表恢复稳定。 05 整形美容与创面修复 · 应用场景：糖尿病足、烧烫伤、难愈性创面、抗衰老。 · 机制：羊膜干细胞的旁分泌作用能促进血管新生，加速肉芽组织生长，且其抗纤维化特性可减少疤痕形成。在皮肤抗衰方面，它能促进胶原蛋白合成，增厚皮肤。 · 案例：糖尿病足是传统治疗的难题，通过将羊膜干细胞联合水凝胶或生物支架移植到创面，可显著缩短溃疡愈合时间，降低截肢风险。在重度烧伤治疗中，利用羊膜作为支架培养干细胞进行移植，能有效促进皮肤再生，减少瘢痕挛缩。 06 呼吸系统疾病 · 应用场景：新冠肺炎后遗症、特发性肺纤维化、慢性阻塞性肺病。 · 机制：羊膜干细胞能归巢到受损的肺组织，分化成肺泡上皮细胞，并通过分泌抗炎因子来减轻肺部炎症、逆转纤维化，从而改善患者的肺功能和血氧水平。 · 案例：在新冠疫情期间，国内外均有使用胎盘/羊膜来源间充质干细胞治疗重症新冠肺炎的临床研究。结果显示，它能显著降低重症患者的细胞因子风暴，提升存活率。目前也有临床研究正将其用于治疗肺纤维化患者。 07 消化系统疾病 · 应用场景：肝硬化失代偿期、溃疡性结肠炎、克罗恩病。 · 机制：羊膜干细胞能分化为肝样细胞，促进受损肝细胞再生，并通过调节肠道免疫来修复肠黏膜。 · 案例：在肝硬化治疗中，通过介入或静脉输注干细胞后，患者腹水减少，白蛋白水平提升，肝功能指标明显好转。治疗克罗恩病的复杂肛瘘时，可实现更高的愈合率，且复发率低于传统手术。局部注射治疗后，超过60%的患者实现瘘道完全愈合。这为许多传统治疗失败的患者提供了保留肛门功能的机会。 08 心血管系统疾病 · 应用场景：心肌梗死、心力衰竭、下肢缺血。 · 机制：羊膜干细胞移植到受损心肌后，能分化为心肌样细胞和血管内皮细胞，改善心脏的射血功能。 · 案例：在心肌梗死动物实验中效果显著。临床研究方面，已有探索通过心导管或直接注射的方式，将干细胞注入梗死区域，观察其安全性及有效性。结果显示，患者的梗死面积缩小，心脏泵血功能得到一定改善。 日本Pure Stem® 产品优势 产品优势： 1：高纯度、高含量； 2：不使用冷冻过的干细胞。冷冻后的干细胞或多或少会有部分破损，与没有冷冻过的干细胞相比，其质量及活性等都会发生改变； 3：根据日本再生医疗法案，所有干细胞均来自经过数道严格检查的健康人体； 细胞培养加工设施： Pure Stem®干细胞上清液产品均是在专门的细胞培养加工设施（CPC）中的高标准无菌培养室完成制备，经过严苛品控工序最终商品化。通过无菌培养室、过滤设备等实施灭菌处理后，再以无血清培养基进行培养加工。 安全性： Pure Stem®资质齐备，所有生物制剂原材料均严格遵守制造规定并接受日本伦理委员会检查。日本很多再生医疗诊所使用的都是Pure Stem®产品，安全有保证。 Pure Stem®干细胞上清液系列产品： 【产品品类】 牙髓干细胞上清液/脂肪干细胞上清液/脐带干细胞上清液； 【剂型】瓶装冻干粉 【含量】1mL/瓶 【包装规格】10瓶/盒 富士HSC-AUヒト脐带&羊水由来幹細胞培養上清液（富士人羊膜高浓度干细胞来源培养上清液）是一种基于羊膜干细胞技术提取的生物活性液体。 1. 来源与成分· 来源：从人羊膜组织中提取干细胞，经培养后获取的上清液。羊膜是胎盘与胎儿之间的半透明薄膜，富含具有高再生能力的干细胞。· 成分：含有多种生长因子（如EGF、FGF、VEGF等）、细胞因子、外泌体及氨基酸、维生素等营养物质，这些成分协同作用，促进细胞修复、再生与代谢。 2. 主要功效· 皮肤修复与抗衰：促进胶原蛋白与弹性纤维生成，改善皱纹、松弛，增强皮肤弹性，加速伤口愈合，减少疤痕形成。· 免疫调节：调节免疫细胞活性，抑制过度炎症反应，辅助改善过敏性疾病、自身免疫性疾病。· 组织再生：对肝损伤、关节损伤、神经损伤等有一定的修复作用，促进受损组织的再生与功能恢复。· 毛发护理：刺激毛囊细胞活性，改善脱发、促进头发生长，增强毛发韧性。3. 使用方式· 静脉点滴：将上清液溶于生理盐水后静脉输注，适用于全身调理，改善慢性疾病、增强免疫力。· 局部注射：注射于面部、头皮、关节等部位，针对性改善皱纹、脱发、关节疼痛等问题。· 外用涂抹：配合美容仪器（如水光针、微针）使用，直接作用于皮肤，促进营养吸收，提升护肤效果。4. 安全性与注意事项· 安全性：经严格质量检测，不含活细胞，过敏与排异反应风险低，但个体差异可能存在，使用前需咨询专业医生。· 禁忌人群：孕妇、哺乳期女性、严重心肝肾功能不全者、对成分过敏者禁用；癌症患者、糖尿病患者需在医生指导下使用。需注意，此类产品多应用于医疗美容或再生医学领域，具体效果因个体差异而异，建议在正规医疗机构由专业医生操作使用。 日本干细胞上清液的优势 日本再生医疗项目走在世界前列，拥有大量干细胞治疗和上清液注射的经验和成功实例，实施严格全面管理，合规性和安全性得到了全面的保证。 干细胞上清液的治疗所用的不是药物，而是人体干细胞在无血清培养（不采用一切动物制品，防止感染症）条件下分泌出的数百种细胞生长因子（这些生长因子在人体内本身就是存在的）。因此干细胞上清液与其说是治疗，不如说是为人体补充随着年龄增长而减少的细胞生长因子，因此安全性是肯定有保障的。 另外干细胞上清液来源于干细胞培养的过程，在干细胞供体的选择・采集这个环节，日本的各大机构也十分谨慎。一般要求是身体健康的日本女性作为干细胞供体，且要进行多项筛查包括HIV・HCV抗体・HBs抗原・HTLV-I抗体・梅毒・单纯疱疹・支原体・细小病毒B19等等。 经过一系列检查后，需要筛选出高质量的干细胞，经过4-5代培养并经过过滤器灭菌处理。为进一步确保其安全性和有效性，工作人员还会对采集的干细胞培养上清液进行质量检查。保证没有杂质，生长因子浓度符合标准才会投入到市场上进行使用。 总而言之，与干细胞治疗不同，干细胞上清液不需要提取客户本人的脂肪进行培养，无需事前准备，随时可以接受治疗，操作便捷所需时间短，同时安全性非常高，几乎没有任何包括过敏和排斥等副作用。 干细胞上清液的应用 干细胞上清液对肌肉，骨骼、内脏、神经、皮肤、毛发等各种身体组织都有促进细胞再生，改善细胞活性的效果。作用于人体各个部分都会产生不同的效果：   应用 应用于身体：修复神经细胞、预防血管硬化、提高免疫力、消除疲劳、恢复身体各项机能。  应用于皮肤：促进胶原蛋白和透明质酸生成，提高皮肤自我再生能力，抵抗皮肤老化。  应用于头发：促进头皮毛母细胞再生，改善发量稀少、脱发等困扰。  干细胞上清液的治疗形式 *静脉点滴 ：将培养上清液配合点滴液进行输液治疗。培养上清液中含有多种细胞成长因子，可以活化体内受损部位的细胞，抑制身体各种组织的衰老现象。 *局部注射（皮下·关节·损伤部位）：将培养上清液注射于想要得到快速疗效的部位。注射后，细胞分裂加速，促进组织复原。比如注射于关节部，抑制关节炎症，促进骨膜再生。 以美容目的注射，可以将干细胞培养上清液直接注入肌肤，还可以配合水光注射、玻尿酸注射、肉毒素注射等，这种方法可以快速发挥效果，让肌肤保持水润、紧致、年轻、纹路细腻，达到1+1>2的深层抗衰效果。 除外，埋线提拉＋人体干细胞培养上清液的组合疗法在日本也十分受欢迎，这种疗法是将人体干细胞培养上清液顺着埋线线材注入皮肤内，可以使人体干细胞培养上清液附着在蛋白线上。（根据需要，也可配合在患者皮肤上注射人体干细胞培养上清液的治疗手法，为患者带来更好的美肤效果。） 在皮肤内侧，由于埋线时被损伤的皮内细胞会在创伤自愈的过程中，产生胶原蛋白。与此同时，人体干细胞培养上清液中含有的成长因子，也会起到促进胶原蛋白再生的效果，使得效果加倍。 直接把含有丰富生理活性物质的干细胞上清液注入头皮，靠这些生长因子修复受损的毛囊细胞，进而改善脱发。如果想要提高效果，在进行头皮注射的同时，还可以进行干细胞上清液的点滴回输。 *直接涂抹于皮肤：可以将干细胞上清液制品直接涂抹于肌肤，改善肌肤问题，促进毛发生长，对过敏性皮炎也有很好的疗效。除此之外，还会有部分机构将干细胞上清液技术使用到点鼻上，通过专业的滴鼻器进行操作，可以在家轻松操作使用。 干细胞上清液治疗案例分享 最后给大家分享一些案例～可以更加直观地感受到干细胞上清液的治疗效果～ 干细胞上清液面部注射案例 干细胞上清液毛发再生案例 干细胞上清液埋线＋玻尿酸＋肉毒素案例 干细胞上清液埋线案例 干细胞上清液埋线案例 往期精彩内容查阅📖👇 NMN与NAD+是什么关系？日本养庵堂NMN、nad+点滴的用法用量使用说明 往期精彩内容查阅📖👇 干细胞上清液与外泌体有什么区别？PureHGF+外泌体Exo在美容抗衰领域有哪些应用 【使用说明】硫酸マグネシウム（硫酸镁）有哪些作用？用法用量及注意事项 不同干细胞上清液（脂肪、脐带、牙髓、羊膜）在细胞因子、功效特性及用法用量上存在哪些差异？ 【再生医疗】NK-EXO免疫细胞外泌体（NK-Exos）在疾病诊断、再生医学、抗衰修复等前沿领域的研究与应用 180款日本医院诊所药局药妆店常见的医药健康产品大全 【使用说明书】日本“大蒜针”武田维生素B注射液（呋硫硫胺アリナミンF50注）成分、副作用、用法用量、注意事项 【再生医疗】日本超级胎盘素リッチプラセンタ使用说明、副作用、用法用量及注意事项 为什么α-硫辛酸（ALA）被称为“抗氧化界的六边形战士”？日新代谢チオクト硫辛酸注射液25mg使用说明 NMN与NAD+是什么关系？日本养庵堂NMN、nad+点滴的用法用量使用说明 【使用说明】ES-玻利他命（ESポリタミン配合顆粒） 润生堂天地苁蓉：滋阴补阳、提精壮气、抗衰老、缓解更年期症状…… NAD+有哪些作用？为什么要补充NAD+？ 日本武田长效降糖药使用说明书：武田老糖（曲格列汀）优势在哪？使用方法和注意事项 长期失眠对人的危害有多严重？当身体发出以下“求救信号”时，绝对不能再熬夜了 二型糖尿病：金丝雀（曲格列汀和卡格列净搭配，摆脱注射胰岛素） 日本人常用三款降压药的区别与选择要点：东和降压氨氯地平片/辉瑞依普利酮高级降压/第一三共奥美沙坦酯&阿折地平HD高级降压 抗癌特效药替吉奥、盐酸阿拉莫林片Anamorelin使用说明，用法用量及副作用注意事项 抗恶性肿瘤产品新型靶向治疗药物使用说明、用法用量及副作用注意事项 日本再生医疗PureStem品牌历史及干细胞上清液、NMN、NAD+产品系列 文章用于交流学习，用药谨遵医嘱！ 免责声明：图文转自网络，不代表本平台立场，仅供读者交流学习，著作权属归原创者所有。如有侵权，请在后台留言联系我们进行删除，谢谢！  10年口碑服务 高端国际医疗与大健康咨询服务 交流咨询V信：S2108885166 整理不易，记得点赞收藏

*本资料仅供医疗卫生专业人士参考，请勿向非医疗卫生专业人士发放 截至04月18日15点59分，近期共有 491 本期刊发布了 1051 篇文章，其中糖尿病相关的文章共 286 篇，覆盖 32 个领域的内容。中国专家参与发表的文章有 60 篇。今日，影响因子最高的文章刊登在 Journal of the American Medical Association (IF: 55.000) 期刊上。 今日头条 Headlines 01 JAMA IF: 55.000 FDA批准无需禁食禁水的GLP-1肥胖症药物 Samantha Anderer 2026年4月17日，美国FDA批准新型口服GLP-1受体激动剂药物orforglipron（商品名Foundayo）用于成人超重或肥胖治疗。该药物无需遵循禁食禁水要求，相比司美格鲁肽（需空腹且30分钟后才能饮食）大幅提升用药灵活性。在临床试验中，17.2mg剂量orforglipron联合低热量饮食和运动，18个月内平均减重约27磅，不良反应以恶心、便秘、腹泻为主，与其他GLP-1药物相似。FDA指出，或forglipron的获批将为肥胖患者提供新选择，有望改善治疗依从性。 本文由 天纳乾坤 编辑 扫描二维码查看源文 JAMA | Ahead of Print. 10.1001/jama.2026.2113 02 Lancet Diabetes Endocrinol IF: 41.800 卡格列肽与司美格鲁肽联合使用对比司美格鲁肽单独使用在日本和台湾超重或肥胖（伴或不伴2型糖尿病）成人中的有效性和安全性（REDEFINE 5）：一项多中心、随机、活性对照、3a期试验 Toshimasa Yamauchi, Niels-Peter Becker, Christoffer Andersen Hagemann, Kuo-Chin Huang, Arihiro Kiyosue, Soo Lim, etc. 2023年4月3日至9月15日，REDEFINE 5试验在日本21个社区及医院和台湾1个站点开展，旨在评估卡格列肽与司美格鲁肽联合用药在东亚超重或肥胖成人中的有效性与安全性。该研究为多中心、随机、双盲、活性对照的3a期试验，共纳入355名筛查对象，其中331人被随机分配至联合用药组（164人）或对照组（167人）。 研究对象需满足年龄≥18岁、BMI≥27 kg/m²（伴随至少2种肥胖相关并发症）或BMI≥35 kg/m²（伴随至少1种并发症），且可伴或不伴2型糖尿病。参与者接受每周1次皮下注射（联合组为卡格列肽2.4 mg+司美格鲁肽2.4 mg，对照组为司美格鲁肽2.4 mg），同时配合生活方式干预，治疗持续68周。 主要终点为68周时体重相对基线的变化。结果显示，联合用药组平均体重降低18.4%（标准差0.7），显著高于对照组的11.9%（标准差0.7），治疗差异为-6.5个百分点（95%置信区间-8.4至-4.6，p<0.0001）。不良事件方面，联合组87%的参与者（164人）报告不良事件，对照组84%（167人），其中最常见的均为胃肠道疾病（联合组53%，对照组51%）。联合组有1例死亡报告，经研究者判断与治疗无关。 该研究结果表明，卡格列肽与司美格鲁肽联合使用在东亚超重或肥胖成人（伴或不伴2型糖尿病）中具有显著减重效果，且安全性可接受。 本文由 牛祥 编辑 扫描二维码查看源文 Lancet Diabetes Endocrinol | Ahead of Print. 10.1016/S2213-8587(25)00402-4 03 EClinicalMedicine IF: 10.000 妊娠糖尿病与孕前肥胖：瑞典女性2型糖尿病的长期风险 Jon Edqvist, Annika Rosengren, Demir Djekic, Christina E. Lundberg, Karin Andréasson, Pigi Dikaiou, etc. 瑞典一项针对115万初产妇的大型队列研究显示，孕前肥胖与妊娠糖尿病（GDM）显著增加女性2型糖尿病（T2DM）长期风险。研究中，1.9%的初产妇被诊断为GDM，其中1.5%被随访至T2DM发生。结果表明，GDM与孕前BMI叠加显著提升T2DM风险：BMI≥35kg/m²且有GDM的女性，T2DM风险是无GDM者的100倍，10年发生率超50%；即使BMI正常（<25kg/m²），GDM也使T2DM风险升高约12倍。生存分析显示，肥胖GDM女性30年T2DM累积风险超50%，且长期风险持续数十年。该研究提示，需对GDM女性进行长期随访，实施生活方式干预以预防T2DM。 本文由 天纳乾坤 编辑 扫描二维码查看源文 EClinicalMedicine | Volume 95, Issue 10.1016/j.eclinm.2026.103912 中国发表（60） China Human mutation IF: 03.700Volume 2026, Issue No.01PAPPA2 c.392G>C Heterozygous Mutation Associates Primary Open-Angle Glaucoma in a Chinese FamilyPAPPA2 c.392G>C突变通过IGFBP5积累降低蛋白水平并导致原发性开角型青光眼DOI: 10.1155/humu/5591097 npj aging IF: 06.000Ahead of Print.No.02Genetic and molecular factors underlying human longevity and epigenetic aging人类长寿及表观遗传衰老的遗传与分子因素DOI: 10.1038/s41514-026-00384-8 Journal of ethnopharmacology IF: 05.400Ahead of Print.No.03Miao Medicine Jinshanxiaoke Granules Alleviates MASLD via Ampk/Ppar-α and Pi3k/Akt-Mediated Restoration of Hepatic Lipid Homeostasis苗族药金砂消克颗粒通过AMPK/Ppar-α和Pi3k/Akt信号通路介导的肝脏脂质稳态恢复缓解代谢功能障碍相关脂肪性肝病DOI: 10.1016/j.jep.2026.121677 European journal of pharmacology IF: 04.700Ahead of Print.No.04Acute Hyperglycemia Induces NETosis and Futile Recanalization after Ischemic Stroke via RAGE/DIAPH1 Pathway急性高血糖通过RAGE/DIAPH1通路诱导缺血性卒中后中性粒细胞胞外陷阱形成及无效再通DOI: 10.1016/j.ejphar.2026.178860 Am J Physiol Endocrinol Metab IF: 03.100Ahead of Print.No.05Exercise ameliorates adipose tissue insulin resistance by activating the lactate/GPR81 signaling pathway in DIO-IR mice运动通过激活乳酸/GPR81信号通路改善DIO-IR小鼠脂肪组织胰岛素抵抗DOI: 10.1152/ajpendo.00321.2025 BMC musculoskeletal disorders IF: 02.400Ahead of Print.No.06Impact of pediatric obesity on surgical outcomes of lower extremity fractures: a nationwide analysis (2010-2019)儿童肥胖对下肢骨折手术结局的影响：2010-2019年全国性分析DOI: 10.1186/s12891-025-09349-6 Int J Behav Nutr Phys Act IF: 05.500Ahead of Print.No.07Effects of exercise on multiple health outcomes in children and adolescents with overweight or obesity: a meta-analysis of 176 randomized controlled trials and its implications for global obesity prevention运动对超重或肥胖儿童和青少年多种健康结局的影响：对176项随机对照试验的荟萃分析及其对全球肥胖预防的意义DOI: 10.1186/s12966-026-01913-0 ESMO gastrointestinal oncologyVolume 11, Issue No.08Real-world treatment outcomes for pancreatic neuroendocrine tumours: a single tertiary referral institute experience胰腺神经内分泌肿瘤的真实世界治疗结局：单一三级转诊机构的经验DOI: 10.1016/j.esmogo.2025.100293 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.09Multi-omics identifies a T2DM-associated immune-regulatory network modulated by electroacupuncture多组学鉴定电针调节的2型糖尿病相关免疫调节网络DOI: 10.3389/fendo.2026.1742131 Theranostics IF: 13.300Volume 16, Issue 10No.10Photothermal-driven multifunctional injectable hydrogel platform for promoting diabetic bone defect repair through synergistic immunomodulation and bone homeostasis光热辅助ZIF-8/TA-MXene异质结水凝胶用于多功能糖尿病骨缺损修复DOI: 10.7150/thno.130240 Frontiers in pharmacology IF: 04.800Volume 17, Issue No.11Mitochondria-mediated inflammation and diabetic wound healing: mechanisms and therapeutic strategies线粒体介导的炎症与糖尿病伤口愈合：机制及治疗策略DOI: 10.3389/fphar.2026.1786693 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.12Association of a novel index, the total cholesterol-high-density lipoprotein-glucose index, with diabetes mellitus in Chinese adults: a retrospective cohort study总胆固醇-高密度脂蛋白-葡萄糖指数与中国成年人糖尿病的关联：一项回顾性队列研究DOI: 10.3389/fendo.2026.1774965 Zhonghua yufang yixue zazhiVolume 60, Issue 4No.13[Clinical pathway of gel-based preparations for wound healing of diabetic foot ulcer]基于凝胶制剂的糖尿病足溃疡创面愈合临床路径DOI: 10.3760/cma.j.cn112150-20250820-00809 Molecular Medicine Reports IF: 03.500Volume 33, Issue 6No.14[Retracted] SUMO1/UBC9‑decreased Nox1 activity inhibits reactive oxygen species generation and apoptosis in diabetic retinopathy[撤回] SUMO1/UBC9降低的Nox1活性抑制糖尿病视网膜病变中的活性氧生成和细胞凋亡DOI: 10.3892/mmr.2026.13877 FCVM IF: 02.900Volume 13, Issue No.15Effect of sarcopenia on risk of atrial fibrillation: a systematic review and meta-analysis of observational studies肌少症对心房颤动风险的影响：一项观察性研究的系统综述与荟萃分析DOI: 10.3389/fcvm.2026.1721219 FCVM IF: 02.900Volume 13, Issue No.16Association between systemic inflammation indices and carotid plaques in acute coronary syndrome急性冠脉综合征患者全身炎症参数与颈动脉斑块的关联DOI: 10.3389/fcvm.2026.1762926 Frontiers in medicine IF: 03.000Volume 13, Issue No.17Duodenal perforation following right nephrectomy in a paraplegic patient with pyonephrosis: a case report and clinical insights糖尿病性截瘫患者术后十二指肠穿孔：一例报告及临床启示DOI: 10.3389/fmed.2026.1745528 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.18The intellectual landscape of cognitive impairment in type 2 diabetes: knowledge structure, research focuses and rising trends2型糖尿病认知障碍的知识图谱：知识结构、研究热点与前沿趋势DOI: 10.3389/fendo.2026.1809245 J Transl Med IF: 07.500Ahead of Print.No.19Low serum dehydroepiandrosterone sulfate is related to diabetic retinopathy in males with type 2 diabetes mellitus低血清硫酸脱氢表雄酮与2型糖尿病男性的糖尿病视网膜病变相关DOI: 10.1186/s12967-026-08121-1 BMC endocrine disorders IF: 03.300Ahead of Print.No.20Altered cortical thickness in type 2 diabetes mellitus patients revealed by coordinate-based meta-analysis基于坐标的荟萃分析揭示2型糖尿病患者的皮质厚度改变DOI: 10.1186/s12902-026-02276-0 PloS one IF: 02.600Volume 21, Issue 4No.21Unveiling the mechanism of calcitriol in treating type 2 diabetes mellitus: A combined network pharmacology and in vitro approach targeting ERS-related pathways骨化三醇通过核心基因STAT3、HSP90AA1、MAPK1和PIK3R1靶向内质网应激相关通路改善2型糖尿病DOI: 10.1371/journal.pone.0347246 FCVM IF: 02.900Volume 13, Issue No.22Association between blood lipid levels, BMI, and hypertension among employees in petrochemical enterprises石油化工行业员工血脂异常、脂质参数、非传统脂质标志物及体重指数与高血压风险的关联DOI: 10.3389/fcvm.2026.1788552 Food & function IF: 05.400Ahead of Print.No.23Multi-omics reveals gut microbiome- and metabolome-specific responses to sugar alcohols多组学揭示肠道微生物组和代谢组对糖醇的特异性反应DOI: 10.1039/d6fo00282j Food science & nutrition IF: 03.800Volume 14, Issue 4No.24Unveiling the Role of Rumen Microbiome in Modulating Intramuscular Fat Deposition of Pingliang Red Cattle揭示瘤胃微生物组在调控平凉红牛肌内脂肪沉积中的作用DOI: 10.1002/fsn3.71681 Frontiers in pharmacology IF: 04.800Volume 17, Issue No.25The physiochemical characteristics of Phragmites communis trin polysaccharides and in vitro anti-diabetic effects of their different fractions芦苇（Phragmites communis Trin）多糖的理化特性及其不同组分的体外抗糖尿病作用DOI: 10.3389/fphar.2026.1727657 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.26Adiposity measured by body roundness index is significantly associated with increased stroke prevalence: a population-based cross-sectional study体圆度指数与卒中患病率：中国心脏健康研究队列的横断面分析DOI: 10.3389/fendo.2026.1761630 Frontiers in nutrition IF: 05.100Volume 13, Issue No.27Nutrition and health canteen-based lifestyle intervention: association with weight management, lipid metabolism regulation, and inflammation alleviation in middle-aged adults营养与健康食堂策略对中年成年人体重及代谢结局的影响：一项单组前后测研究DOI: 10.3389/fnut.2026.1754647 FCVM IF: 02.900Volume 13, Issue No.28The triglyceride-glucose index shows a stronger association with complex coronary artery disease than the ACEF score among young and middle-aged adults with aortic valve calcification甘油三酯-葡萄糖指数在合并主动脉瓣钙化的中青年成人中与复杂冠状动脉疾病的关联比ACEF评分更强DOI: 10.3389/fcvm.2026.1753991 Frontiers in medicine IF: 03.000Volume 13, Issue No.29Association between serum vitamin D levels and the risk of diabetic retinopathy: a meta-analysis血清维生素D水平与糖尿病视网膜病变风险的关联：一项荟萃分析DOI: 10.3389/fmed.2026.1771156 Frontiers in immunology IF: 05.900Volume 17, Issue No.30Autoimmune polyglandular syndrome type 1 with compound heterozygous AIRE gene pathogenic variants and stage 1 type 1 diabetes mellitus: case report and literature review of Chinese population伴复合杂合AIRE基因突变的1型自身免疫性多内分泌综合征合并1型糖尿病1期：中国人群病例报告及文献综述DOI: 10.3389/fimmu.2026.1781304 JEADV IF: 08.000Ahead of Print.No.31Predictors of clinical response to biologics in psoriasis: A systematic review and meta-analysis银屑病患者对生物制剂临床反应的预测因素：一项系统综述和荟萃分析DOI: 10.1111/jdv.70462 J Cachexia Sarcopenia Muscle IF: 09.100Volume 17, Issue 2No.32Sarcopenic Obesity in Children: An Emerging Complication Evidenced by Clinical Data and a Juvenile Mouse Model儿童肌少性肥胖：通过临床数据和幼年小鼠模型证实的一种新兴并发症DOI: 10.1002/jcsm.70278 Pak J Med Sci IF: 01.700Volume 42, Issue 3No.33Risk factors for surgical site infections after hysterectomy: A systematic review and meta-analysis子宫切除术后手术部位感染风险因素的系统综述与荟萃分析DOI: 10.12669/pjms.42.3.13718 FCVM IF: 02.900Volume 13, Issue No.34Effect of obstructive sleep apnea-hypopnea syndrome on myocardial mechanics in obese patients阻塞性睡眠呼吸暂停低通气综合征严重程度对肥胖患者心肌力学的影响：一项使用整体纵向应变的前瞻性研究DOI: 10.3389/fcvm.2026.1672585 Scientific reports IF: 03.900Ahead of Print.No.35The relationship between abdominal obesity indices and the risk of metabolic dysfunction-associated fatty liver disease: a prospective cohort study腹型肥胖指数与代谢功能障碍相关脂肪肝疾病风险的关系：一项前瞻性队列研究DOI: 10.1038/s41598-026-49030-z Int J Mol Med IF: 05.800Volume 57, Issue 6No.36Context‑dependent duality of the apelin/elabela‑APJ system in diabetes and its complications (Review)阿佩林/埃拉贝拉-APJ系统在糖尿病及其并发症中的上下文依赖性双重作用（综述）DOI: 10.3892/ijmm.2026.5832 Zhonghua yufang yixue zazhiVolume 60, Issue 4No.37[Analysis of the comorbidity prevalence and related factors of elevated blood pressure and overweight and obesity in children aged 7-9 years in Zhejiang Province from 2018 to 2024]2018-2024年浙江省7-9岁儿童血压升高与超重肥胖共病患病率及相关因素分析DOI: 10.3760/cma.j.cn112150-20250828-00836 Int J Mol Med IF: 05.800Volume 57, Issue 6No.38Glycolytic lactylation modulates cell death decisions in diabetic kidney disease: Metabolic‑epigenetic interplay between ferroptosis and autophagy in fibrotic remodeling (Review)糖酵解乳酸化调节糖尿病肾病中的细胞死亡决定：纤维化重塑中铁死亡与自噬的代谢-表观遗传相互作用（综述）DOI: 10.3892/ijmm.2026.5831 Renal failure IF: 03.000Volume 48, Issue 1No.39Targeting the NAD(+)-SIRT3 axis to mitigate metabolic memory in diabetic kidney disease靶向NAD(+)-SIRT3轴以减轻糖尿病肾病中的代谢记忆DOI: 10.1080/0886022X.2026.2648912 Journal of Advanced Research IF: 13.000Ahead of Print.No.40SFRP2 aggravates diabetic kidney disease by repressing the renal protective CH25H/25-hydroxycholesterol axis in mesangial cellsSFRP2通过抑制系膜细胞中肾脏保护性CH25H/25-羟胆固醇轴加重糖尿病肾病DOI: 10.1016/j.jare.2026.04.043 Metabolism IF: 11.900Ahead of Print.No.416-Phosphofructokinase-2/fructose-2,6-bisphosphatase 3: A potential target in the development of diabetes and its complications6-磷酸果糖激酶-2/果糖-2,6-双磷酸酶3：糖尿病及其并发症治疗的潜在靶点DOI: 10.1016/j.metabol.2026.156621 Journal of food science IF: 03.400Volume 91, Issue 4No.42Preparation of Soluble Dietary Fiber From Lotus Root by Enzymatic Hydrolysis Under High Pressure and Its Hypoglycemic Effect in Vivo高压下酶解从莲藕制备可溶性膳食纤维及其体内降血糖效果DOI: 10.1111/1750-3841.71022 Journal of diabetes research IF: 03.400Volume 2026, Issue 1No.43A Nomogram Prediction Model and Validation of Hypoglycemia Risk in Patients With Decompensated Cirrhosis and Type 2 Diabetes失代偿期肝硬化合并2型糖尿病患者低血糖风险的诺模图预测模型及验证DOI: 10.1155/jdr/6812038 Int J Mol Med IF: 05.800Volume 57, Issue 6No.44RNA‑binding proteins as epithelial transcriptome orchestrators in gastric cancer: Immune‑metabolic crosstalk and therapeutic vulnerability (Review)RNA结合蛋白作为胃癌上皮转录组的调控者：免疫代谢串扰与治疗脆弱性（综述）DOI: 10.3892/ijmm.2026.5827 Medicine IF: 01.400Volume 105, Issue 16No.45Saturation effect of anion gap in predicting long-term mortality in critically ill patients with chronic obstructive pulmonary disease (COPD): A retrospective cohort study based on the MIMIC-IV database阴离子间隙的饱和效应对重症慢性阻塞性肺疾病（COPD）患者长期死亡率的预测作用：基于MIMIC-IV数据库的回顾性队列研究DOI: 10.1097/MD.0000000000041364 Biomaterials science IF: 05.700Ahead of Print.No.46Macrophage polarization-regulating hydrogels for bone regeneration用于骨再生的巨噬细胞极化调节水凝胶DOI: 10.1039/d6bm00283h Advanced science IF: 14.100Ahead of Print.No.47Dual-Mode Type I/II Photosensitization of a Stable Mesoporous Hydrogen-Bonded Organic Framework for Antibacterial Therapy双模式I/II型光动力作用的稳定介孔氢键有机框架用于抗菌治疗DOI: 10.1002/advs.75173 Frontiers in medicine IF: 03.000Volume 13, Issue No.48Development and internal validation of a LASSO-based clinical prediction model for nontuberculous mycobacterial pulmonary disease versus pulmonary tuberculosis基于LASSO的非结核分枝杆菌肺病与肺结核临床预测模型的开发及内部验证DOI: 10.3389/fmed.2026.1785899 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.49Latest advances and controversies of exercise therapy in the management of type 2 diabetes运动疗法在2型糖尿病管理中的最新进展与争议DOI: 10.3389/fendo.2026.1822069 Frontiers in psychiatry IF: 03.200Volume 17, Issue No.50Prevalence and influencing factors of insomnia in patients with coronary heart disease: a systematic review and meta-analysis冠心病患者失眠的患病率及影响因素：一项系统综述和荟萃分析DOI: 10.3389/fpsyt.2026.1748293 Theranostics IF: 13.300Volume 16, Issue 10No.51Bioadhesive and hemostatic microneedles integrated with NIR-responsive Ti(3)C(2)/CeO(2) heterojunction nanozymes for accelerated diabetic wound healing集成NIR响应型Ti(3)C(2)/CeO(2)异质结纳米酶的生物粘附止血微针用于加速糖尿病创面愈合DOI: 10.7150/thno.130627 Physiological reports IF: 01.900Volume 14, Issue 8No.52Ponatinib confers adult human cardiomyocyte toxicity via inhibition of AKT signaling普纳替尼通过抑制AKT信号传导导致成人人心肌细胞毒性DOI: 10.14814/phy2.70877 Cardiovascular Toxicology IF: 03.700Volume 26, Issue 5, Page 44- 45No.53Sex-Specific Associations Between Cadmium Exposure and Mortality Risk in Cardiovascular Disease Patients: A Cohort Study Integrating Molecular Mechanisms of Myocardial Dysfunction镉暴露与心血管疾病患者死亡率风险的性别特异性关联：整合心肌功能障碍分子机制的队列研究DOI: 10.1007/s12012-026-10117-8 Animal microbiome IF: 04.400Volume 8, Issue 1No.54Multi-omics characterization of blood metabolites and cervical microbiota associated with estrus in simmental cattle西门塔尔牛发情状态分析：血液代谢组学和宫颈微生物群揭示发情相关的代谢重编程和群落结构改变DOI: 10.1186/s42523-026-00571-8 Indian Pediatrics IF: 01.500Ahead of Print.No.55Weight Loss and Metabolic Remission in Obese Children with MASLD: Reflections on the Use of ALT and Cohort Selection肥胖儿童代谢相关脂肪性肝病（MASLD）的体重减轻与代谢缓解：关于ALT使用及队列选择的反思DOI: 10.1007/s13312-026-00335-2 Frontiers in nutrition IF: 05.100Volume 13, Issue No.56High-fat diet, triglyceride glucose index, and gastrointestinal cancer: integrative insights from human and animal studies高脂饮食、甘油三酯-葡萄糖指数与胃肠道癌症风险：一项全国性研究DOI: 10.3389/fnut.2026.1734895 Food science & nutrition IF: 03.800Volume 14, Issue 4No.57Mechanisms and Production of Hypoglycaemic Peptides: Exploring the Potential of Chlamydomonas reinhardtii莱茵衣藻：功能性食品开发的低血糖肽可持续来源DOI: 10.1002/fsn3.71790 Nature metabolism IF: 20.800Ahead of Print.No.58Longitudinal multimorbidity trajectories shape personalized glycaemic patterns纵向慢性病共存轨迹塑造个性化血糖模式DOI: 10.1038/s42255-026-01512-0 Journal of global health IF: 04.300Volume 16, Issue No.59Individual and household determinants of overweight and obesity among children and adolescents in China中国儿童和青少年超重与肥胖的个体及家庭决定因素DOI: 10.7189/jogh.16.04096 Journal of global health IF: 04.300Volume 16, Issue No.60National, regional and provincial prevalence of peripheral artery disease in Chinese adults in 2023: an updated systematic review and modelling study2023年中国成年人外周动脉疾病的国家、地区及省级患病率：一项更新的系统综述与建模研究DOI: 10.7189/jogh.16.04155 其他发布内容（223） More Published Articles Am J Prev Cardiol IF: 05.900Ahead of Print.No.01Small, dense LDL-C as a predictor of cardiovascular risk and benefit of alirocumab in patients with recent acute coronary syndrome receiving optimized statin treatment小而密低密度脂蛋白胆固醇作为近期急性冠脉综合征患者接受优化他汀治疗时心血管风险的预测因子及阿利西尤单抗的治疗益处DOI: 10.1016/j.ajpc.2026.101643 Basic Research in Cardiology IF: 08.000Ahead of Print.No.02Empagliflozin improves metabolism and prevents myocardial and coronary dysfunction in streptozotocin-diabetic and non-diabetic rats subjected to ischemia/reperfusion恩格列净改善代谢并预防链脲佐菌素诱导的糖尿病及非糖尿病大鼠缺血/再灌注时的心肌和冠状动脉功能障碍DOI: 10.1007/s00395-026-01177-6 JAMA IF: 55.000Ahead of Print.No.03FDA Approves Weekly Basal Insulin for Adults With Type 2 DiabetesFDA批准首个每周一次基础胰岛素用于成人2型糖尿病DOI: 10.1001/jama.2026.2111 JAMA IF: 55.000Ahead of Print.No.04Metabolically Healthy Obesity in Children Still Raises Cardiometabolic Risk儿童代谢健康型肥胖仍会增加心血管代谢风险DOI: 10.1001/jama.2026.2112 Endocrine connections IF: 02.800Ahead of Print.No.05Metformin improves endotoxemia and alters folliculogenesis in women with polycystic ovary syndrome二甲双胍改善多囊卵巢综合征女性的内毒素血症并改变卵泡发生DOI: 10.1530/EC-26-0120 JMIR IF: 06.000Ahead of Print.No.06A Digital Diabetes Self-Management Education and Support Program Integrated With Continuous Glucose Monitoring Improves Glycemic Control: A Randomized Controlled Trial结合持续葡萄糖监测的数字化糖尿病自我管理教育与支持项目改善血糖控制：一项随机对照试验DOI: 10.2196/78321 PLOS global public health IF: 02.500Volume 6, Issue 4No.07Morbidity burden and predictors of hospitalization among unaccompanied migrants and persons prone to statelessness in Ghana加纳无人陪伴移民及易无国籍人士的疾病负担与住院预测因素DOI: 10.1371/journal.pgph.0006316 Appl Physiol Nutr Metab IF: 02.000Volume 51, Issue No.08Low- and no-calorie sweeteners and health: unravelling the evidence and controversy低热量和无热量甜味剂与健康：解读证据与争议DOI: 10.1139/apnm-2025-0440 Science IF: 45.800Volume 392, Issue 6795No.09HNF1B integrates signals in a feed-forward loop driving kidney disease progressionHNF1B通过前馈环路整合信号驱动肾脏疾病进展DOI: 10.1126/science.aea3219 Brain and behavior IF: 02.700Volume 16, Issue 4No.10Prenatal (1-3)IGF-1 Treatment Is Ineffective and Behaviorally Detrimental in a Rat Model of Cortical Malformation产前(1-3)IGF-1治疗在皮质畸形大鼠模型中无效且对行为有害DOI: 10.1002/brb3.71405 BMC infectious diseases IF: 03.000Ahead of Print.No.11Characterising the urinary metabolome in HIV/TB coinfection and the impact of antiretroviral treatmentHIV/TB合并感染患者尿代谢组的表征及抗逆转录病毒治疗的影响DOI: 10.1186/s12879-025-12389-x Br J Gen Pract IF: 05.200Ahead of Print.No.12Pre-diagnostic prescription patterns in pancreatic cancer: a retrospective cohort study胰腺癌诊断前的处方模式：一项回顾性队列研究DOI: 10.3399/BJGP.2025.0780 Contemporary clinical trials IF: 01.900Ahead of Print.No.13Effects of pistachio consumption on cognition, cardiometabolic risk factors, and life satisfaction in older adults: Protocol for a remote-based randomized controlled trial开心果食用对老年人认知、心脏代谢风险因素及生活满意度的影响：一项基于远程的随机对照试验方案DOI: 10.1016/j.cct.2026.108316 Cell Mol Neurobiol IF: 04.800Ahead of Print.No.14Unknotting the Role of circRNAs and IGF2BP3 in Alzheimer's Disease阐明circRNAs和IGF2BP3在阿尔茨海默病中的作用DOI: 10.1007/s10571-026-01724-8 Amino acids IF: 02.400Ahead of Print.No.15Maternal dietary citrulline supplementation increases fetal growth and programs pancreatic development in the lambs母羊日粮补充瓜氨酸可促进羔羊胎儿生长并调控胰腺发育DOI: 10.1007/s00726-026-03520-6 Ital J Dermatol Venerol IF: 02.600Ahead of Print.No.16Acral acanthotic anomaly: a comprehensive review肢端棘状异常：综合综述DOI: 10.23736/S2784-8671.26.08479-3 Obesity science & practice IF: 01.900Volume 12, Issue 2No.17Trends and Disparities in Obesity-Related Mortality Among U.S. Adults: A CDC WONDER Analysis (1968-2025)1968-2025年美国成人肥胖相关死亡率趋势：基于CDC WONDER数据的全国分析DOI: 10.1002/osp4.70146 Ulus Travma Acil Cerrahi Derg IF: 00.800Volume 32, Issue 3No.18A new scoring system for the prediction of mortality in Fournier's gangrene: The Eğin scoreEgin评分：一种预测Fournier坏疽死亡率的新评分系统DOI: 10.14744/tjtes.2025.55901 Obesity IF: 04.700Ahead of Print.No.19Structural Drivers of Neighborhood Food Access: Implications for Policy Change社区食物获取的结构性驱动因素：对政策变革的启示DOI: 10.1002/oby.70205 Cell biochemistry and function IF: 02.700Volume 44, Issue 4No.20Melanocortin 3 Receptors Do Not Specifically Localize to Primary Cilia in Cultured Human and Rodent Neurons黑色素皮质素3受体在培养的人类和啮齿动物神经元中并不特异性定位于初级纤毛DOI: 10.1002/cbf.70216 American journal of men's health IF: 02.400Volume 20, Issue 2No.21Unmasking Masculinity: Biological, Behavioral, and Social Determinants of Testosterone Deficiency in U.S. Men, 2011-2023揭示男性气质：2011-2023年美国男性睾酮缺乏的生物学、行为学和社会决定因素DOI: 10.1177/15579883261433808 Public health nutrition IF: 03.000Ahead of Print.No.22What's on the Menu? A Review of School Meal Quality Across 29 Countries菜单上有什么？29个国家学校餐质量回顾DOI: 10.1017/S1368980026102456 Childhood obesity IF: 01.400Ahead of Print.No.23Parents' Insights on a Summer Obesity Prevention Intervention at SUN Meals Program Sites for Elementary School-Aged Children家长对针对小学年龄段儿童的SUN Meals项目点夏季肥胖预防干预措施的见解DOI: 10.1177/21532176261443775 Obes Res Clin Pract IF: 02.300Ahead of Print.No.24Financial incentives for weight management in adolescents and young adults: A systematic review and meta-analysis of randomized controlled trials青少年和年轻成年人的体重管理财务激励：一项随机对照试验的系统综述和荟萃分析DOI: 10.1016/j.orcp.2026.03.007 Pancreatology IF: 02.700Ahead of Print.No.25Glucagon-like Peptide-1 receptor agonists are not associated with increased risk of pancreatic cancer: A systematic review and meta-analysis胰高血糖素样肽-1受体激动剂与胰腺导管腺癌风险增加无关：一项系统综述和荟萃分析DOI: 10.1016/j.pan.2026.04.005 Advances in wound care IF: 05.600Ahead of Print.No.26Overcoming Challenges in Wound Infection: Biofilm and Antimicrobial Resistance克服伤口感染的挑战：生物膜与抗菌药物耐药性DOI: 10.1177/21621918261440437 BMJ open IF: 02.300Volume 16, Issue 4No.27Optimising sleep and managing stress by integrating a behavioural intervention during cardiac rehabilitation: rationale and design of the OPTICARE-RESST multicentre randomised controlled trial心脏康复期间整合行为干预优化睡眠和管理压力：OPTIMCARE-RESST多中心随机对照试验的原理与设计DOI: 10.1136/bmjopen-2026-117963 Prog Neuropsychopharmacol Biol Psychiatry IF: 03.900Ahead of Print.No.28Chronobiological disruption in ADHD: Developmental mechanisms linking sleep, behavior, and comorbid conditions注意缺陷多动障碍（ADHD）中的昼夜节律紊乱：睡眠、行为和共病的发育机制DOI: 10.1016/j.pnpbp.2026.111700 Urology IF: 02.000Ahead of Print.No.29Varicocele and Untreated Hypogonadism Synergistically Increase Prostate Cancer Risk via Testosterone Shunt Physiology and can be Ameliorated with Testosterone Therapy精索静脉曲张与未治疗性腺功能减退症通过睾酮分流生理机制协同增加前列腺癌风险DOI: 10.1016/j.urology.2026.04.016 The Journal of surgical research IF: 01.700Ahead of Print.No.30Factors Associated With Complications and Increased Length of Stay After Bariatric Surgery in Pediatric Patients儿童患者减重手术后并发症及住院时间延长的相关因素DOI: 10.1016/j.jss.2026.03.065 The American journal of surgery IF: 02.700Ahead of Print.No.31Endoscopic sleeve gastroplasty: A déjà-vu?内镜下袖状胃成形术：一种似曾相识？DOI: 10.1016/j.amjsurg.2026.116976 Advanced science IF: 14.100Ahead of Print.No.32ACLY-Driven Metabolic Reprogramming Promotes Histone Acetylation and Inflammation-Associated Fibrosis in Chronic Kidney DiseaseACLY驱动的代谢重编程促进慢性肾脏病中的组蛋白乙酰化和炎症相关纤维化DOI: 10.1002/advs.75247 J Chin Med Assoc IF: 02.400Volume 89, Issue 4No.33Comprehensive review of current management and precision medicine in pancreatic cancer胰腺癌当前治疗及精准医学综合综述DOI: 10.1097/JCMA.0000000000001365 New Zealand medical journal IF: 01.300Volume 139, Issue 1633No.34Dietary sugar intake as a risk factor for early-onset colorectal cancer in young New Zealanders新西兰年轻人饮食中糖分摄入作为早发性结直肠癌的风险因素DOI: 10.26635/6965.7378 Gastro Hep advancesVolume 5, Issue 5No.35The Jejunal Microbiota in Patients With Chronic Pancreatitis: Results From a Pilot Study慢性胰腺炎患者的空肠微生物群：一项试点研究结果DOI: 10.1016/j.gastha.2026.100907 IJTLD openVolume 3, Issue 4No.36Can we optimise the TB response amid funding constraints using evidence-based, cost-effective strategies优化结核病应对策略DOI: 10.5588/ijtldopen.25.0771 ESMO gastrointestinal oncologyVolume 11, Issue No.37Impact of diabetes mellitus on treatment efficacy in patients with advanced pancreatic cancer: the Italian, multicenter, observational PANCAKE study糖尿病和血糖模式对胰腺癌患者生存结果及化疗有效性的影响DOI: 10.1016/j.esmogo.2025.100276 Clinical epidemiology IF: 03.200Volume 18, Issue No.38Incidence and Risk Factors of Postoperative Urinary Retention in Gynecologic Surgery: A Systematic Review and Meta-Analysis妇科手术后术后尿潴留的发生率及危险因素：一项系统综述和荟萃分析DOI: 10.2147/CLEP.S595297 Frontiers in pharmacology IF: 04.800Volume 16, Issue No.39Molecular and pathophysiological intersections between arterial hypertension, pulmonary inflammation and diabetes mellitus动脉高血压、肺部炎症与糖尿病之间复杂的免疫学、分子及病理生理相互作用DOI: 10.3389/fphar.2025.1734861 Int J Telemed Appl IF: 02.200Volume 2026, Issue No.40Implementation of Integrated Telemedicine Services in Resource-Limited Somalia: A Case Study of Baano Healthcare Technology索马里综合远程医疗服务的实施：以Baano医疗技术为例的案例研究DOI: 10.1155/ijta/3667956 Kidney medicine IF: 03.400Volume 8, Issue 3No.41How Far Is a Kidney Willing to Go? Kidney Transplant Outcomes Based on Distance Donor Kidney Travels to Transplant Centers已故捐赠者肾脏移植的距离与结局：一项多中心分析DOI: 10.1016/j.xkme.2026.101262 bioRxivVolume 2026, Issue No.42Genetic and pharmacologic modulation of RAGE rescues the diabetes-mediated impairments to bone at multiple length scales2型糖尿病小鼠模型中晚期糖基化终产物(AGEs)诱导骨细胞衰老并改变骨粘弹性特性DOI: 10.64898/2026.04.02.716153 Curēus IF: 01.300Volume 18, Issue 3No.43When Metabolism Recovers but the Brain Does Not: A Case Report of Posterior Reversible Encephalopathy Syndrome (PRES)-Like Encephalopathy After Extreme Metformin-Associated Lactic Acidosis当代谢恢复而大脑未恢复时：一例严重二甲双胍相关乳酸酸中毒后类似可逆性后部脑病综合征（PRES）的脑病病例报告DOI: 10.7759/cureus.105129 Frontiers in pharmacology IF: 04.800Volume 17, Issue No.44Analysis of metabolic rewiring in MDR1-overexpressing drug-resistant glioblastomaMDR1过表达胶质母细胞瘤细胞的代谢重编程增强药物耐药性并可通过二甲双胍靶向逆转DOI: 10.3389/fphar.2026.1760920 Biomaterials advances IF: 06.000Ahead of Print.No.45A biomimetic in vitro glomerular filtration barrier model for investigating renal barrier dysfunction in hyperglycemia用于研究高血糖状态下肾脏屏障功能障碍的仿生体外肾小球滤过屏障模型DOI: 10.1016/j.bioadv.2026.214885 Bioorganic chemistry IF: 04.700Ahead of Print.No.46Network pharmacology study and preclinical validation highlight the anti-diabetic potential of Persicaria lapathifolia (L.) Delarbre leaf extract via AMPK/Akt pathways网络药理学研究与临床前验证凸显水蓼（Persicaria lapathifolia (L.) Delarbre）叶提取物通过AMPK/Akt通路的抗糖尿病潜力DOI: 10.1016/j.bioorg.2026.109857 Kidney360 IF: 03.000Ahead of Print.No.47CRITICAL ROLE OF DYSREGULATED AUTOPHAGY IN PATHOPHYSIOLOGY OF PODOCYTOPATHY自噬失调在足细胞病病理生理学中的关键作用DOI: 10.34067/KID.0000001152 J Clin Endocrinol Metab IF: 05.100Ahead of Print.No.48Insights from changes in NDEV biomarkers of metabolism: Effects of PPARγ and GLP1 receptor agonists on brain metabolism代谢中神经元衍生细胞外囊泡（NDEV）生物标志物变化的见解：PPARγ和GLP1受体激动剂对脑代谢的影响DOI: 10.1210/clinem/dgag176 APMIS : IF: 02.600Volume 134, Issue 4No.49A Survey of the Microbiome, Culturome and ARG Profile of a Cohort of Chronic Diabetic Foot Lesions慢性糖尿病足溃疡队列的微生物组、培养组及抗生素抗性基因谱调查DOI: 10.1111/apm.70203 J Infect Dev Ctries IF: 01.200Volume 20, Issue 3No.50Microbiology and antibiotic resistance of diabetes-related foot infections in Brazil: a systematic review巴西糖尿病相关足部感染的微生物学及抗生素耐药性：一项系统综述DOI: 10.3855/jidc.20077 Annals of African medicine IF: 00.600Ahead of Print.No.51Hyperglycemia with Ketoacidosis following Acute Necrotizing Pancreatitis: A Case Suggestive of Pancreatogenic Diabetes急性坏死性胰腺炎后高血糖伴酮症酸中毒：提示胰源性糖尿病的病例DOI: 10.4103/aam.aam_735_25 American journal of perinatology IF: 01.200Ahead of Print.No.52A Practical Approach to Insulin Pump, CGM, and Automated Insulin Delivery in the Management of Type 1 Diabetes in Pregnancy妊娠1型糖尿病管理中胰岛素泵、CGM及自动胰岛素输注的实用方法DOI: 10.1055/a-2854-5752 Journal of medical case reports IF: 00.900Ahead of Print.No.53Osteomyelitis of anterior maxilla involving bilateral sinuses post-rodenticide toxicity: a case report灭鼠药中毒后累及双侧上颌窦的上颌前部骨髓炎一例报告DOI: 10.1186/s13256-026-06012-z J Vitreoretin Dis IF: 00.500Ahead of Print.No.54Survival Rates After Pars Plana Vitrectomy for Proliferative Diabetic Retinopathy增殖性糖尿病视网膜病变行玻璃体切除术后的生存率DOI: 10.1177/24741264261432178 Curēus IF: 01.300Volume 18, Issue 4No.55Clinical Outcomes of High-Dose Aflibercept 8 mg in Polypoidal Choroidal Vasculopathy: A Systematic Review and Meta-Analysis玻璃体腔内注射8mg阿柏西普治疗息肉状脉络膜血管病变的系统综述与荟萃分析DOI: 10.7759/cureus.106769 Experimental Eye Research IF: 02.700Ahead of Print.No.56Texture-based analysis of retinal OCT images can discriminate the early impact of type 1 and type 2 diabetes on the retina: evidence from animal models基于纹理分析的视网膜OCT图像可区分1型和2型糖尿病对视网膜的早期影响：来自动物模型的证据DOI: 10.1016/j.exer.2026.111028 Klin Monbl Augenheilkd IF: 00.800Ahead of Print.No.57[Optical coherence tomography angiography]光学相干断层扫描血管造影术DOI: 10.1055/a-2729-1450 Curēus IF: 01.300Volume 18, Issue 3No.58Dextromethorphan for Restless Legs Syndrome: Testing the Glutamate Theory右美沙芬治疗不宁腿综合征：谷氨酸理论的验证DOI: 10.7759/cureus.105315 The spine journal IF: 04.700Ahead of Print.No.59Evaluating the Utility of Melatonin in Spine Surgery: A Systematic Review and Meta-Analysis of Randomized Clinical Trials褪黑素在脊柱手术中的效用评估：一项随机临床试验的系统综述和荟萃分析DOI: 10.1016/j.spinee.2026.04.020 BMC pregnancy and childbirth IF: 02.700Ahead of Print.No.60Women's experiences of navigating gestational diabetes in Denmark: a qualitative study of healthcare and self-care, with a focus on dietary education and delivery丹麦女性应对妊娠糖尿病的经历：一项关于医疗保健和自我护理的定性研究，重点关注饮食教育和分娩DOI: 10.1186/s12884-026-09055-8 Current nutrition reports IF: 05.500Volume 15, Issue 1No.61Plant-Based Diet and Pregnancy-Related Disorders: A Narrative Review植物性饮食与妊娠相关疾病：叙述性综述DOI: 10.1007/s13668-026-00759-z Antioxidants & redox signaling IF: 06.100Ahead of Print.No.62Impact of Endothelium-Derived Mitochondrial Reactive Oxygen Species on Obesity-Associated Atherosclerosis内皮源性线粒体活性氧对肥胖相关动脉粥样硬化的影响DOI: 10.1177/15230864261443843 Obstetrics and Gynecology IF: 04.700Ahead of Print.No.63Cardiovascular-Related Maternal Mortality心血管相关孕产妇死亡率DOI: 10.1097/AOG.0000000000006297 Subst Abuse Treat Prev Policy IF: 03.200Ahead of Print.No.64A hospital-based multi-centric observational study to explore the prevalence and correlates of non-medical use and dependence of pregabalin among the patients with substance use disorder in Punjab & Chandigarh以医院为基础的多中心观察性研究，探索旁遮普邦和昌迪加尔物质使用障碍患者中普瑞巴林的非医疗使用及依赖的患病率和相关因素DOI: 10.1186/s13011-026-00730-9 American journal of therapeutics IF: 02.500Ahead of Print.No.65Two-Year Biomarker Trends and Kidney/Mortality Outcomes After Semaglutide Versus Phentermine-Topiramate and Naltrexone-Bupropion in People With Obesity and Without Diabetes司美格鲁肽与苯丁胺-托吡酯和纳曲酮-安非他酮在无糖尿病肥胖人群中使用两年后的生物标志物趋势及肾脏/死亡率结局DOI: 10.1097/MJT.0000000000002132 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.66Cardiometabolic Profiles of Oral and Subcutaneous Glucagon-Like Peptide-1 Receptor Mono-Agonists in Adults With Overweight or Obesity: A Systematic Review and Network Meta-Analysis超重或肥胖成人中口服和皮下胰高血糖素样肽-1受体单激动剂的心血管代谢特征：一项系统综述和网络荟萃分析DOI: 10.1111/dom.70742 Curēus IF: 01.300Volume 18, Issue 3No.67Association of Neutrophil-to-Lymphocyte Ratio With Early Diabetic Nephropathy in Patients With Type 2 Diabetes Mellitus中性粒细胞-淋巴细胞比率与2型糖尿病患者早期糖尿病肾病的关联DOI: 10.7759/cureus.105087 Curēus IF: 01.300Volume 18, Issue 3No.68Uncontrolled Diabetes as the Sole Risk Factor in a Rare Candida glabrata Tubo-Ovarian Abscess未控制的糖尿病作为罕见光滑念珠菌输卵管卵巢脓肿的唯一危险因素DOI: 10.7759/cureus.105065 Health science reports IF: 02.100Volume 9, Issue 4No.69Joint Modeling of Fasting Blood Sugar Changes and Cardiovascular Disease Progression in Type-2 Diabetes Mellitus Patients: A Retrospective Cohort Study2型糖尿病患者空腹血糖变化与心血管疾病进展的联合建模：一项回顾性队列研究DOI: 10.1002/hsr2.72327 Rural and remote health IF: 02.500Volume 26, Issue 2No.70Understanding physical activity adherence in vulnerable adults with type 2 diabetes in the rural Brazilian Amazon理解巴西亚马逊农村地区弱势成年2型糖尿病患者的体力活动依从性DOI: 10.22605/RRH10544 J Clin Endocrinol Metab IF: 05.100Ahead of Print.No.71Polygenic risk scores and lifestyle factors predicting new onset of type 2 diabetes in the Japanese general population多基因风险评分和生活方式因素预测日本普通人群2型糖尿病的新发DOI: 10.1210/clinem/dgag171 Bone IF: 03.600Ahead of Print.No.72Proteomic profiling links increased mast cell activity in regenerating callus to impaired scaffold-guided bone regeneration in diabetic rats蛋白质组学分析揭示糖尿病大鼠再生愈伤组织中肥大细胞活性增强与支架引导骨再生受损的关联DOI: 10.1016/j.bone.2026.117901 J Infect Dev Ctries IF: 01.200Volume 20, Issue 3No.73Risk factors linked to surgical site infections: a prospective survey on an Albanian population following abdominal surgery与手术部位感染相关的风险因素：阿尔巴尼亚人群腹部手术后的前瞻性调查DOI: 10.3855/jidc.22105 Metab Syndr Relat Disord IF: 01.700Ahead of Print.No.74Can the Diagnosis of Metabolic Syndrome and the Severity of the Disease Be Determined with the Help of Inflammatory Biomarkers?炎症生物标志物能否辅助代谢综合征的诊断及疾病严重程度判断？DOI: 10.1177/15578518261443921 Endocrine research IF: 01.800Ahead of Print.No.75Broad-Spectrum Effects of Carbohydrate Reduction on Inflammatory and Immune Mediators in Type 2 Diabetes碳水化合物减少对2型糖尿病炎症和免疫介质的广谱影响DOI: 10.1080/07435800.2026.2659579 Clinical science IF: 07.700Volume 140, Issue 5No.76Burn-associated metabolic dysfunction: could extracellular vesicles play a role?烧伤相关代谢功能障碍：细胞外囊泡是否可能发挥作用？DOI: 10.1042/CS20260147 Mol Nutr Food Res IF: 04.200Volume 70, Issue 8No.77Supercritically Extracted Mealworm Oil Alleviates High-Fat Diet-Induced Obesity by Modulating Gut Microbiota in Mice超临界萃取黄粉虫油通过调节小鼠肠道菌群缓解高脂饮食诱导的肥胖DOI: 10.1002/mnfr.70445 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.78Effects of Premeal Versus Postmeal Metformin Administration on Postmeal Glycemic Control in Individuals With Type 2 Diabetes Mellitus: A Randomized, 8-Week Crossover Study餐前与餐后服用二甲双胍对2型糖尿病患者餐后血糖控制的影响：一项随机、8周交叉研究DOI: 10.1111/dom.70768 Curēus IF: 01.300Volume 18, Issue 3No.79Anti-Glutamic Acid Decarboxylase 65 (Anti-GAD65) Autoimmune Encephalopathy: A Case of Diagnostic and Treatment Challenge抗谷氨酸脱羧酶65自身免疫性脑炎：一例诊断与治疗挑战的病例DOI: 10.7759/cureus.105312 Curēus IF: 01.300Volume 18, Issue 3No.80Type 3c Diabetes Mellitus: Epidemiology, Diagnosis, Management, and Research Imperatives With Insights From the United Arab Emirates and Global Contexts3c型糖尿病：阿拉伯联合酋长国及全球背景下的流行病学、病理生理学、诊断、管理及临床意义综述DOI: 10.7759/cureus.105089 Biology of Sport IF: 05.000Volume 43, Issue No.81Aging reimagined: Bridging clinical modulation and scientific breakthroughs衰老：不可避免的命运还是可改变的状况？DOI: 10.5114/biolsport.2026.156224 Advances in physical educationVolume 7, Issue 3No.82The Effect of Wrestling Training and Sauna Practice on Cortisol and Insulin Hormones摔跤训练和桑拿练习对皮质醇和胰岛素激素的影响DOI: 10.4236/ape.2017.73024 Saudi journal of ophthalmology IF: 01.200Volume 40, Issue 1No.83Sociodemography, diabetes mellitus clinical parameters, and retinal morphology as predictors of neurodegeneration in preclinical diabetic retinopathy临床及视网膜形态学分析揭示的糖尿病视网膜病变前期神经退行性改变的预测因素DOI: 10.4103/sjopt.sjopt_42_24 Frontiers in nutrition IF: 05.100Volume 13, Issue No.84Legume intake on gut microbiome and glycemia in type 2 diabetes management: narrative review豆类摄入对2型糖尿病的影响：肠道微生物群与血糖结局综述DOI: 10.3389/fnut.2026.1785186 Frontiers in nutrition IF: 05.100Volume 13, Issue No.85Long-term effects of plant vs. animal protein supplementation on body composition, muscle strength, physical performance, and cardiometabolic risk factors in adults:a systematic review and meta-analysis of randomized controlled trials18岁及以上成年人长期摄入植物性蛋白与动物性蛋白对身体成分、肌肉力量、体能及心脏代谢风险因素的影响：系统综述与荟萃分析DOI: 10.3389/fnut.2026.1813846 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.86Differentiating obesity with and without prediabetes through skin findings: results from PREVIEW sub-study通过皮肤表现鉴别有或无糖尿病前期的肥胖患者：PREVIEW子研究结果DOI: 10.3389/fendo.2026.1796607 Frontiers in pediatrics IF: 02.000Volume 14, Issue No.87Maternal opioids downregulate adiponectin receptor signaling and alter growth in offspring: pilot study母体阿片类药物暴露对新生儿ADIPOR1表达和身体成分的性别特异性及剂量依赖性影响DOI: 10.3389/fped.2026.1755488 Taiwan journal of ophthalmology IF: 01.200Volume 16, Issue 1No.88Therapeutic targets for fibro-inflammation in Graves' orbitopathy格雷夫斯眶病纤维炎症通路的治疗靶点：综合综述DOI: 10.4103/tjo.TJO-D-25-00057 bioRxivVolume 2026, Issue No.89Post-Inhibitory Rebound by δ-Cells Converts Inhibition into Excitation and Confers Islet Plasticityδ细胞的抑制后反弹将抑制转化为兴奋并赋予胰岛可塑性DOI: 10.1101/2025.11.10.687745 bioRxivVolume 2026, Issue No.90Insulin Growth Factor 1 affects glutamate receptor activity differently in primary cultures of neocortical versus hippocampal neuronsIGF-1通过AMPA受体信号调控新皮层神经元的谷氨酸能反应DOI: 10.64898/2026.04.04.716504 bioRxivVolume 2026, Issue No.91A Real Time Quaking Induced Conversion (RT-QuIC) Assay for Detection of Misfolded Insulin Protein实时震颤诱导转换（RT-QuIC）检测胰岛素错误折叠和聚集的方法开发DOI: 10.64898/2026.04.08.717350 bioRxivVolume 2026, Issue No.92From bats to humans: uncovering ISG15 as a new resistance factor in type 1 diabetes从蝙蝠到人类：揭示ISG15作为1型糖尿病的新抵抗因子DOI: 10.64898/2026.04.02.713107 Cancer Treat Res Commun IF: 02.400Ahead of Print.No.93Apoptosis induction and migration suppression through regulation of IGF-1R/FoxO signaling pathways in Panc1 pancreatic cancer cells by hAMSCs secretome: An in vitro cell-based therapy人类羊膜间充质干细胞分泌物通过调控IGF-1R/FoxO信号通路诱导Panc1胰腺癌细胞凋亡并抑制迁移：一种体外细胞疗法DOI: 10.1016/j.ctarc.2026.101172 Curēus IF: 01.300Volume 18, Issue 3No.94Effectiveness and Safety of Saroglitazar in Patients With Metabolic Disease in India Stratified by Estimated Glomerular Filtration Rate (eGFR): A Retrospective, Observational, Electronic Medical Record (EMR)-Based Real-World Evidence Study印度代谢性疾病患者按估算肾小球滤过率(eGFR)分层的Saroglitazar疗效与安全性：一项回顾性、观察性、基于电子病历(EMR)的真实世界证据研究DOI: 10.7759/cureus.105083 Curēus IF: 01.300Volume 18, Issue 3No.95Re-evaluating Cardiovascular Risk: A Narrative Review Challenging the Cholesterol Hypothesis and Identifying Modern Dietary Drivers重新评估心血管风险：一篇挑战胆固醇假说并识别现代饮食驱动因素的叙事性综述DOI: 10.7759/cureus.105311 Health science reports IF: 02.100Volume 9, Issue 4No.96A Cross-Sectional Study on the Role of Biochemical Markers in Cardiovascular Disease Risk Assessment: Comparison of Urban and Rural Populations in Pakistan巴基斯坦城乡人群心血管疾病风险评估中生化标志物作用的横断面研究DOI: 10.1002/hsr2.72374 Annals of neurosciences IF: 02.400Ahead of Print.No.97A Follow-up Study of Peripheral Neurological and Biochemical Involvement in Gestational and Overt Diabetes Mellitus妊娠期和显性糖尿病的外周神经及生化受累随访研究DOI: 10.1177/09727531261435737 Frontiers in neuroscience IF: 03.200Volume 20, Issue No.98Attenuation of mGluR1/5-dependent synaptic plasticity and ERK pathway dysfunction in the hippocampus of diabetic rats糖尿病大鼠海马中mGluR1/5依赖性突触可塑性衰减及ERK通路功能障碍DOI: 10.3389/fnins.2026.1814915 Pak J Med Sci IF: 01.700Volume 42, Issue 3No.99Association of exclusive breast feeding and early cereal introduction with the development of Type-1 diabetes mellitus (T1DM)纯母乳喂养与早期谷物辅食添加对1型糖尿病(T1DM)发生的关联研究DOI: 10.12669/pjms.42.3.13063 Annals of African medicine IF: 00.600Ahead of Print.No.100Prevalence of Nonalcoholic Fatty Liver Disease in Type 1 Diabetes Mellitus and Utility of Noninvasive Tests1型糖尿病患者非酒精性脂肪肝疾病的患病率及无创检测的效用DOI: 10.4103/aam.aam_716_25 Urogynecology IF: 01.200Ahead of Print.No.101Age and Perioperative Outcomes Following Minimally Invasive Sacrocolpopexy年龄与微创骶骨固定术后围手术期结局的关系DOI: 10.1097/SPV.0000000000001859 Clinical science IF: 07.700Volume 140, Issue 5No.102An emerging role for eosinophils as pro-angiogenic drivers of adipose tissue beiging嗜酸性粒细胞作为脂肪组织褐变的促血管生成驱动因子的新兴作用DOI: 10.1042/CS20250051 Pediatric dermatology IF: 01.200Ahead of Print.No.103Setmelanotide in Bardet-Biedl Syndrome: A Case Report塞姆洛肽治疗巴德-毕德尔综合征的病例报告DOI: 10.1111/pde.70186 Curēus IF: 01.300Volume 18, Issue 3No.104Correlation of Urinary Bisphenol A and Phthalates With Overweight and Obesity in Children儿童尿中双酚A和邻苯二甲酸盐与超重及肥胖的相关性DOI: 10.7759/cureus.105308 Curēus IF: 01.300Volume 18, Issue 3No.105Association of Lifestyle Factors With Blood Pressure Control Among Hypertensive U.S. Adults: An Analysis of the National Ambulatory Medical Care Survey (NAMCS) 2010-2015美国高血压成年人的生活方式因素、社会人口统计学特征与血压控制的关联：一项基于国家门诊医疗护理调查（NAMCS）2010-2015年的分析DOI: 10.7759/cureus.105112 Curēus IF: 01.300Volume 18, Issue 3No.106Contraception in Women With Medical Comorbidities: Clinical Risk Stratification and Individualized Therapeutic Strategies患有合并症女性的避孕管理：临床风险分层与个体化治疗策略DOI: 10.7759/cureus.105102 Curēus IF: 01.300Volume 18, Issue 3No.107Efficacy of Risankizumab in Moderate to Severe Psoriasis Considering Body Mass Index: A Scoping ReviewRisankizumab在中重度斑块状银屑病中的疗效与安全性：一项范围综述DOI: 10.7759/cureus.105055 Curēus IF: 01.300Volume 18, Issue 3No.108Meal Frequency and Body Composition in Obese Adults Presenting for a Weight-Loss Program: A Cross-Sectional Study肥胖成人减重计划中膳食频率与身体成分的横断面研究DOI: 10.7759/cureus.105105 Health science reports IF: 02.100Volume 9, Issue 4No.109Beyond BMI: Visceral Fat and Comorbidities as Major Risk Factors for Urinary Incontinence in Elderly Women-A Case-Control Study中年和老年女性尿失禁：与身体成分和慢性疾病的关联DOI: 10.1002/hsr2.72330 Paediatrics & child health IF: 02.000Volume 31, Issue 3No.110A new Canadian clinical practice guideline for managing obesity in children: Some tried, some true and some very new加拿大新发布的儿童肥胖管理临床实践指南：部分经验证、部分需谨慎、部分全新DOI: 10.1093/pch/pxaf075 Frontiers in pain research IF: 02.700Volume 7, Issue No.111Systemic inflammation mediating the relationship between lifestyle factors and musculoskeletal pain: a systematic review系统性综述：全身炎症在介导生活方式与肌肉骨骼疼痛关系中的作用DOI: 10.3389/fpain.2026.1755744 Food science & nutrition IF: 03.800Volume 14, Issue 4No.112Nutritional Status, School Time, and Eating Patterns in Children From 7 to 10 Years: Quantitative Evaluation of Macro and Micronutrients in the School Diet7-10岁儿童营养状况、在校时间与饮食模式：学校饮食中宏量与微量营养素的定量评估DOI: 10.1002/fsn3.71719 Neuroscience appliedVolume 5, Issue No.113Weight matters: Higher BMI is associated with changes in the brain connectome in health and depression体重很重要：健康和抑郁状态下，更高的体重指数与大脑连接组变化相关DOI: 10.1016/j.nsa.2026.106984 Frontiers in pharmacology IF: 04.800Volume 17, Issue No.114Editorial: Women in gastrointestinal and hepatic pharmacology: 2024社论：2024年胃肠与肝脏药理学领域的女性研究DOI: 10.3389/fphar.2026.1838196 bioRxivVolume 2026, Issue No.115Colonic metabolomic and transcriptomic alterations in a mouse model of metabolic syndrome代谢综合征小鼠模型中的结肠代谢组学和转录组学改变DOI: 10.64898/2026.04.02.716131 bioRxivVolume 2026, Issue No.116Engineered Lactate Catabolizing Probiotics Reveal Timescale Dependent Microbiome-Host Metabolic Coupling工程化乳酸分解益生菌揭示依赖时间尺度的微生物组-宿主代谢耦合DOI: 10.64898/2026.04.07.716956 bioRxivVolume 2026, Issue No.117A VLP-based immunogen that elicits selective anti-Myostatin antibodies, enhances muscle mass and strength, and reduces adiposity一种基于病毒样颗粒的免疫原，可引发选择性抗肌抑素抗体，增强肌肉质量和力量并减少肥胖DOI: 10.64898/2026.04.06.716693 bioRxivVolume 2026, Issue No.118Early Epigenetic and Metabolic Responses to the Adipocyte Secretome Reveal Stress-Adaptive States in Triple-Negative Breast Cancer脂肪细胞分泌组对三阴性乳腺癌的早期表观遗传和代谢反应揭示应激适应状态DOI: 10.64898/2026.04.06.716548 Arthroplasty today IF: 02.100Volume 37, Issue SupplNo.119Rural vs Urban Outcomes in Total Knee and Hip Arthroplasty: A Study of Patient-Reported Outcomes and Web-Based Tool Efficacy农村与城市在全膝关节和髋关节置换术中的结局对比：一项关于患者报告结局和基于网络工具有效性的研究DOI: 10.1016/j.artd.2025.101885 Circ Popul Health OutcomesAhead of Print.No.120Leveraging Neighborhood-Level Interventions to Improve Cardiovascular Health: A Scoping Review利用社区层面干预措施改善心血管健康：一项范围综述DOI: 10.1161/CIRCOUTCOMES.125.012870 The Journal of school health IF: 01.800Volume 96, Issue 5No.121Physical Activity Disparities Between Students With and Without Disabilities Across School-Based Physical Activity Contexts有残疾和无残疾学生在基于学校的体力活动场景中的体力活动差异DOI: 10.1111/josh.70154 Aliment Pharmacol Ther IF: 06.700Ahead of Print.No.122Affinity Proteomics-Based Non-Invasive Detection of Clinically Significant Liver Disease基于亲和蛋白质组学的临床显著肝病无创检测DOI: 10.1111/apt.70656 British journal of surgery : IF: 08.800Ahead of Print.No.123Navigating Uncharted Territory in Surgical Innovation: A systematic review of non-standard Metabolic Bariatric Surgery procedures探索外科创新的未知领域：一项非标准代谢减重手术流程的系统综述DOI: 10.1093/bjs/znag047 Eating and weight disorders IF: 02.800Ahead of Print.No.124Associations between job stress, eating behaviors, and body mass index among healthcare professionals at King Faisal Medical Complex, Taif, Saudi Arabia沙特阿拉伯泰夫国王费萨尔医疗中心医疗保健专业人员的工作压力、饮食行为与体重指数之间的关联DOI: 10.1007/s40519-026-01856-2 Trends Endocrinol Metab IF: 12.600Ahead of Print.No.125A fuel partitioning perspective on appetite suppression by GLP-1 receptor agonists从燃料分配视角探讨GLP-1受体激动剂的食欲抑制作用DOI: 10.1016/j.tem.2026.03.013 Surg Obes Relat Dis IF: 03.800Ahead of Print.No.126Early and late complications after laparoscopic Roux-en-Y gastric bypass and sleeve gastrectomy: a nationwide propensity-score matched study腹腔镜Roux-en-Y胃旁路术和袖状胃切除术后的早期和晚期并发症：一项全国性倾向得分匹配研究DOI: 10.1016/j.soard.2026.03.016 Clinical nutrition IF: 07.400Ahead of Print.No.127Sarcopenic obesity: Call to action and nutritional agenda from the international clinical nutrition community肌少症性肥胖：国际临床营养界的行动呼吁与营养议程DOI: 10.1016/j.clnu.2026.106645 PLoS medicine IF: 09.900Volume 23, Issue 4No.128Association between gabapentinoid treatment, concurrent use with opioid or benzodiazepine and the risk of drug poisoning: A self-controlled case series study加巴喷丁类药物使用与全因药物中毒风险的自控制病例系列研究DOI: 10.1371/journal.pmed.1005035 Diabetes Metab Res Rev IF: 06.000Volume 42, Issue 4No.129Changes in Brain Volumetric Measures Associated With Type 1 Diabetes Depict an Evolutionary Adaptation Process to Developmental Cognitive Demands1型糖尿病相关的脑体积测量变化描述对发育性认知需求的进化适应过程DOI: 10.1002/dmrr.70169 Diabetes Metab Res Rev IF: 06.000Volume 42, Issue 4No.130An 11-Year Study to Predict Major Complications According to Biological Age in Patients With Diabetes: National Health Information Database (NHIS-NHID 2002-2020)根据生物年龄预测糖尿病患者主要并发症的11年研究：国家健康信息数据库（NHIS-NHID 2002-2020）DOI: 10.1002/dmrr.70170 Nature communications IF: 15.700Ahead of Print.No.131Precision cardiovascular risk prediction in type 1 diabetes: An IMI2 SOPHIA analysis1型糖尿病的精准心血管风险预测：一项IMI2 SOPHIA研究分析DOI: 10.1038/s41467-026-72029-z Kidney medicine IF: 03.400Volume 8, Issue 3No.132Cost-Effectiveness Analysis of Artificial Intelligence-Driven Risk Stratification in Patients With Diabetic Kidney Disease in the US Veterans Population美国退伍军人健康管理局糖尿病肾病人工智能驱动风险分层策略的成本效益分析DOI: 10.1016/j.xkme.2026.101261 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.133Use of Glucagon-Like Peptide-1 Receptor Agonists and Risk of Parkinson's Disease: Scandinavian Cohort Study胰高血糖素样肽-1受体激动剂的使用与帕金森病风险：一项斯堪的纳维亚队列研究DOI: 10.1111/dom.70760 The Journal of surgical research IF: 01.700Ahead of Print.No.134Glucagon-Like Peptide-1 Receptor Agonists in Managing High Stoma Output: A Scoping Review胰高血糖素样肽-1受体激动剂在高造瘘口输出管理中的范围综述DOI: 10.1016/j.jss.2026.03.080 Curēus IF: 01.300Volume 18, Issue 3No.135Sodium-Glucose Cotransporter-2 Inhibitors Across the Glycemic Spectrum: Cardiovascular and Renal Outcomes With Mechanistic Insights从2型糖尿病到心血管与肾脏保护：SGLT2抑制剂的综合综述DOI: 10.7759/cureus.105114 Science IF: 45.800Volume 392, Issue 6795No.136Stem cell control in the lung by an autocrine injury-activated Igf complex肺部中由自分泌损伤激活的Igf复合物调控的干细胞DOI: 10.1126/science.adt1310 Curr Opin Clin Nutr Metab Care IF: 03.500Ahead of Print.No.137Perioperative drug pharmacokinetics in patients with obesity肥胖患者围手术期药物药代动力学DOI: 10.1097/MCO.0000000000001225 Curēus IF: 01.300Volume 18, Issue 3No.138Right Meralgia Paresthetica After a Laparoscopic ProGrip™ Bilateral Implant for Inguinal Hernia Repair: A Case Report腹腔镜ProGrip™双侧植入修复腹股沟疝术后发生右侧股外侧皮神经炎：一例报告DOI: 10.7759/cureus.105059 Curēus IF: 01.300Volume 18, Issue 3No.139Compartment Syndrome Secondary to Envenomation by Bothrops asper: Anesthetic Challenges矛头蝮蛇咬伤致骨筋膜室综合征：麻醉挑战DOI: 10.7759/cureus.105327 Cancer epidemiology IF: 02.300Ahead of Print.No.140Maternal obesity and the intergenerational risk of cancer: Epidemiologic evidence and mechanistic insights母体肥胖与后代癌症的代际风险：流行病学证据与机制见解DOI: 10.1016/j.canep.2026.103079 PloS one IF: 02.600Volume 21, Issue 4No.141Parental, pregnancy and neonatal characteristics during the perinatal period as potential risk factors for childhood cancer: FeToxCancer case-control study瑞典基于人群的病例对照研究：围产期特征与儿童癌症风险DOI: 10.1371/journal.pone.0333752 EHJ-QCCO IF: 04.600Ahead of Print.No.142Anti-Obesity Medications in Adults with Congenital Heart Disease: A Comprehensive Review and Expert Clinical Recommendations成人先天性心脏病患者的抗肥胖药物：综合综述与专家临床建议DOI: 10.1093/ehjqcco/qcag067 Disease-a-month IF: 04.300Ahead of Print.No.143Approved weight loss drugs for obesity with a thorough emphasis on GLP-1 agonist medications: A systematic review针对肥胖症的已批准减肥药物，重点强调GLP-1受体激动剂药物：一项系统综述DOI: 10.1016/j.disamonth.2026.102113 BMJ open IF: 02.300Volume 16, Issue 4No.144Metformin use and the risk of incident osteoarthritis among individuals with diabetes: a register-based nested case-control study二甲双胍使用与糖尿病患者新发骨关节炎风险的关系：一项基于登记的巢式病例对照研究DOI: 10.1136/bmjopen-2025-115587 Blood neoplasiaVolume 3, Issue 2No.145Acid ceramidase inhibition enhances BCL-2 targeting in venetoclax-resistant acute myeloid leukemia酸性神经酰胺酶与B细胞淋巴瘤因子2在急性髓系白血病中的联合靶向DOI: 10.1016/j.bneo.2026.100196 BMJ open IF: 02.300Volume 16, Issue 4No.146Dapagliflozin for cardiorenal protection after intensive care unit discharge: a protocol for a randomised controlled trial evaluating dapagliflozin at ICU discharge for cardiorenal protection (DAPA-ICU)达格列净在重症监护病房出院后的心肾保护：一项评估达格列净在重症监护病房出院时进行心肾保护的随机对照试验方案（DAPA-ICU）DOI: 10.1136/bmjopen-2025-108119 JBI evidence implementationVolume 24, Issue 2No.147Optimizing cystic fibrosis-related diabetes screening in adults using the oral glucose tolerance test (OGTT): a single center mixed methods study优化成人囊性纤维化相关糖尿病筛查使用口服葡萄糖耐量试验（OGTT）：单中心混合方法研究DOI: 10.1097/XEB.0000000000000531 Mol Nutr Food Res IF: 04.200Volume 70, Issue 8No.148Lactational Western-Style Fat Exposure in Mice Programs Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Male Offspring哺乳期西式脂肪暴露在小鼠中导致雄性后代代谢功能障碍相关脂肪性肝病（MASLD）DOI: 10.1002/mnfr.70468 Mol Nutr Food Res IF: 04.200Volume 70, Issue 8No.149Chia Oil Supplementation Attenuates Obesity-Induced Hepatic Steatosis, PVAT Inflammation, and Endothelial Dysfunction in Mice奇亚籽油补充剂减轻肥胖诱导的肝脏脂肪变性、血管周脂肪组织炎症和小鼠内皮功能障碍DOI: 10.1002/mnfr.70469 Clinical nephrology IF: 01.000Ahead of Print.No.150From shelter to stroke: A mediation-proxy analysis of homelessness-associated stroke risk in dialysis patients从庇护所到卒中：透析患者无家可归相关卒中风险的中介代理分析DOI: 10.5414/CN111835 BMC nephrology IF: 02.400Ahead of Print.No.151Case report: dual pathology of LMX1B-associated nephropathy and iga nephropathy in a middle-aged woman病例报告：中年女性LMX1B相关肾病与IgA肾病的双重病变DOI: 10.1186/s12882-026-04973-3 Antioxidants & redox signaling IF: 06.100Ahead of Print.No.152Beneficial Effects of Corylin on Metabolic Dysfunction-Associated Fatty Liver DiseaseCorylin对代谢功能障碍相关脂肪肝疾病的有益作用DOI: 10.1177/15230864261443781 Frontiers in public health IF: 03.400Volume 14, Issue No.153Determinants of self-monitoring adherence in type 2 diabetes: bridging the gap in patient care约旦2型糖尿病患者自我血糖监测依从性研究DOI: 10.3389/fpubh.2026.1784888 Diabetes care IF: 16.600Ahead of Print.No.154Glycemic Outcomes of Endocrinology Consultation for Type 2 Diabetes by Visit Modality: A Retrospective Cohort Study2型糖尿病内分泌科咨询方式对血糖结局的影响：一项回顾性队列研究DOI: 10.2337/dc25-1134 Clin Transl Gastroenterol IF: 03.000Ahead of Print.No.155Predictors of Discordance Between Controlled Attenuation Parameter and Magnetic Resonance-Proton Density Fat Fraction in Hepatic Steatosis肝脏脂肪变性中控制衰减参数与磁共振质子密度脂肪分数不一致的预测因素DOI: 10.14309/ctg.0000000000001042 Asia Pac J Public Health IF: 00.900Ahead of Print.No.156Prevalence and Factors Associated With Undiagnosed Diabetes Mellitus, Hypertension, and Hypercholesterolemia Among Orang Asli in Malaysia马来西亚原住民中未确诊的糖尿病、高血压和高胆固醇血症的患病率及相关因素DOI: 10.1177/10105395261435159 Arthroscopy : IF: 05.400Ahead of Print.No.157Editorial Commentary: Outcomes and Complication Risk in Type 1 Diabetic Patients Undergoing Hip Arthroscopy-Diabetes is NOT a Single Disease社论评论：1型糖尿病患者接受髋关节镜检查的结局与并发症风险——糖尿病并非单一疾病DOI: 10.1002/arj.70142 J Diabetes Investig IF: 03.000Ahead of Print.No.158Data-driven cluster analysis of adults with prediabetes: Findings from the Japan diabetes prevention study基于数据的糖尿病前期成人聚类分析：日本糖尿病预防研究的发现DOI: 10.1111/jdi.70302 Clinical transplantation IF: 01.900Volume 40, Issue 4No.159Center Geography or Center Practice? Decomposing Geographic Variation in Access to Kidney Transplantation Before Versus After Circles中心地理因素还是中心实践因素？分解圆前后肾移植获取机会的地理差异DOI: 10.1111/ctr.70543 Arthroscopy : IF: 05.400Ahead of Print.No.160Type 1 Diabetes Mellitus Correlates With Increased Postoperative Complications and Rates of Conversion to Total Hip Arthroplasty Following Hip Arthroscopy for Femoroacetabular Impingement Syndrome1型糖尿病与股髋臼撞击综合征髋关节镜术后并发症增加及全髋关节置换术转换率升高相关DOI: 10.1002/arj.70140 Analytical chemistry IF: 06.700Ahead of Print.No.161Isotope Dilution NanoLC-MS/MS Quantitation of Methylglyoxal DNA-Protein Cross-Links: Formation and Repair in Human Cells同位素稀释纳升级液相色谱-串联质谱法定量甲基乙二醛DNA-蛋白质交联物：人类细胞中的形成与修复DOI: 10.1021/acs.analchem.5c06852 Biomaterials science IF: 05.700Ahead of Print.No.162Engineering immune-evasive islet replacement: cell-intrinsic and peri-graft strategies构建免疫逃逸型胰岛替代：细胞内在策略与移植物周围策略DOI: 10.1039/d6bm00014b Journal of periodontal research IF: 03.400Ahead of Print.No.163Periodontitis and Incident Diabetes Mellitus: A Nationwide Cohort Study From Korea牙周炎与新发糖尿病：来自韩国的全国性队列研究DOI: 10.1111/jre.70111 eLifeVolume 14, Issue No.164Uncovering shared and tissue-specific molecular adaptations to intermittent fasting in liver, brain, and muscle揭示间歇性禁食在肝脏、大脑和肌肉中的共享及组织特异性分子适应DOI: 10.7554/eLife.107332 Foot and ankle international IF: 02.200Ahead of Print.No.165How Much First Ray Should Be Sacrificed? Rethinking Surgical Strategy in the Diabetic Forefoot应该牺牲多少第一跖骨？重新思考糖尿病前足的手术策略DOI: 10.1177/10711007261434976 Foot and ankle international IF: 02.200Ahead of Print.No.166Comparative Effectiveness of Transmetatarsal First Ray Amputation and Hallux Amputation in a Diabetic Foot Ulcer Cohort糖尿病足溃疡队列中跖骨间第一列截肢术与拇趾截肢术的比较有效性DOI: 10.1177/10711007261425671 Australasian journal on ageing IF: 01.800Volume 45, Issue 2No.167The Epidemiological Profile of Older Adults of Pacific Peoples Ethnicity in New Zealand Assessed for Home Support and Aged Residential Care新西兰接受家庭支持和老年住宅护理评估的太平洋民族老年人流行病学特征DOI: 10.1111/ajag.70143 Ann Clin Transl Neurol IF: 03.900Ahead of Print.No.168Risk of Non-Arteritic Anterior Ischemic Optic Neuropathy in Idiopathic Intracranial Hypertension Patients Treated with GLP-1 Receptor Agonists接受GLP-1受体激动剂治疗的特发性颅内高压患者中非动脉炎性前部缺血性视神经病变的风险DOI: 10.1002/acn3.70406 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.169Semaglutide Treatment in Young Adults Living With Type 2 Diabetes: A Post Hoc Analysis From the SUSTAIN and PIONEER Clinical Trials司美格鲁肽治疗2型糖尿病年轻成年患者：来自SUSTAIN和PIONEER临床试验的事后分析DOI: 10.1111/dom.70770 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.170Pharmacokinetic Bioequivalence of Orforglipron Tablets and Capsules in Healthy Participants With Obesity or Overweight奥伐格隆片剂和胶囊剂在健康肥胖或超重参与者中的药代动力学生物等效性DOI: 10.1111/dom.70783 Future medicinal chemistry IF: 03.400Ahead of Print.No.171Design, synthesis, and antidiabetic activity of new furan-clubbed 1,2,3-triazole derivatives as α-glucosidase inhibitors新型呋喃连接1,2,3-三唑衍生物作为α-葡萄糖苷酶抑制剂的设计、合成及抗糖尿病活性DOI: 10.1080/17568919.2026.2658012 J Reprod Infant Psychol IF: 01.600Ahead of Print.No.172The experience of women with diabetes in pre-pregnancy, antenatal and postpartum period in Australia澳大利亚患有糖尿病的女性在孕前、产前及产后的经历DOI: 10.1080/02646838.2026.2655979 Curēus IF: 01.300Volume 18, Issue 3No.173Ten-Year Cardiovascular Disease Risk Among Employees Aged 40 Years and Older at the University of Sharjah: A Cross-Sectional Study沙迦大学40岁及以上员工十年心血管疾病风险：一项横断面研究DOI: 10.7759/cureus.105045 Curēus IF: 01.300Volume 18, Issue 3No.174Probiotic and Postbiotic Delivery Systems for the Management of Chronic Wounds: A Review of Emerging Strategies益生菌在慢性伤口治疗中的应用：综述DOI: 10.7759/cureus.105081 Curēus IF: 01.300Volume 18, Issue 3No.175Peri-Operative Surgical Risk and Postoperative Outcomes in Patients With COPD Undergoing Abdominal Surgery: A Retrospective Observational Study慢性阻塞性肺疾病患者接受腹部手术的围手术期手术风险及术后结局：一项回顾性观察研究DOI: 10.7759/cureus.105280 Curēus IF: 01.300Volume 18, Issue 3No.176Awareness of Diabetic Retinopathy Among Known Diabetics巴基斯坦某三甲医院已知糖尿病患者对糖尿病视网膜病变的认知：一项横断面研究DOI: 10.7759/cureus.105168 Curēus IF: 01.300Volume 18, Issue 3No.177Clinical Profile of Patients With Isolated Lateral Rectus Palsy in Adults成人孤立性外直肌麻痹患者的临床特征DOI: 10.7759/cureus.105158 Case reports in orthopedics IF: 00.600Volume 2026, Issue No.178Periprosthetic Joint Infection With Salmonella Species 2 Years After Unicompartmental Knee Arthroplasty Treated With Debridement, Antibiotics, and Implant Retention (DAIR): A Case Report and Review of the Literature单室膝关节置换术后2年沙门氏菌属假体周围关节感染采用清创、抗生素及植入物保留（DAIR）治疗：病例报告与文献综述DOI: 10.1155/cro/2056500 IJVM IF: 01.100Volume 2026, Issue No.179A Sedentary Behaviour Reduction Programme in Patients With Peripheral Arterial Disease: A Mixed-Method Feasibility Study外周动脉疾病患者久坐行为减少方案：一项混合方法可行性研究DOI: 10.1155/ijvm/1159242 IJID regions IF: 01.700Volume 18, Issue No.180Clinical approach to drug-resistant tuberculosis of the brain and spine in a low-income setting: A case series低收入环境下脑和脊柱耐药性结核病的临床处理：病例系列研究DOI: 10.1016/j.ijregi.2026.100847 Saudi journal of ophthalmology IF: 01.200Volume 40, Issue 1No.181Factors associated with the endothelial cell density of the donor corneas与供体角膜内皮细胞密度相关的因素DOI: 10.4103/sjopt.sjopt_231_24 ISME communications IF: 06.100Volume 6, Issue 1No.182Bayesian inference captures metabolite-bacteria interactions in a microbial community贝叶斯推理捕捉微生物群落中的代谢物-细菌相互作用DOI: 10.1093/ismeco/ycag066 Drugs in context IF: 02.800Volume 15, Issue No.183Effectiveness of silymarin with lifestyle intervention in NAFLD and metabolic syndrome: a prospective single-arm study水飞蓟素联合生活方式干预在非酒精性脂肪肝和代谢综合征中的有效性：一项前瞻性单臂研究DOI: 10.7573/dic.2025-12-5 Curēus IF: 01.300Volume 18, Issue 3No.184Severe Hypercalcemia and Acute Kidney Injury as Initial Manifestations of Multisystem Sarcoidosis in an Adolescent With Type 1 Diabetes: A Case Report1型糖尿病青少年以严重高钙血症和急性肾损伤为首发表现的多系统结节病1例报告DOI: 10.7759/cureus.105121 Curēus IF: 01.300Volume 18, Issue 3No.185Impact of Dedicated Nurse Time on Electronic Health Record (EHR)-Based Diabetes Quality Measures: A Pre-Post Observational Study利用注册护士提高家庭医学诊所糖尿病质量指标依从性的质量改进项目DOI: 10.7759/cureus.105341 Curēus IF: 01.300Volume 18, Issue 3No.186Transcatheter Aortic Valve Replacement Within a Structured Secondary Prevention Framework in Cardiovascular Disease心血管疾病结构化二级预防框架下的经导管主动脉瓣置换术DOI: 10.7759/cureus.105072 Kardiologia Polska IF: 03.800Ahead of Print.No.187D-dimer testing in cardiovascular disease: Laboratory and clinical pitfalls心血管疾病中的D-二聚体检测：实验室和临床陷阱DOI: 10.33963/v.phj.112156 Retinal cases & brief reportsVolume 19, Issue 5No.188DIET-INDUCED RESOLUTION OF MACULAR OEDEMA FOLLOWING REMISSION OF TYPE 2 DIABETES MELLITUS IN A PATIENT UNDERGOING THERAPEUTIC CARBOHYDRATE REDUCTION治疗性碳水化合物减少后2型糖尿病缓解患者的饮食诱导黄斑水肿消退DOI: 10.1097/ICB.0000000000001614 Curēus IF: 01.300Volume 18, Issue 3No.189Knowledge, Attitudes, and Practices of Non-ophthalmologist Physicians and Optometrists Regarding Diabetic Retinopathy: A Scoping Review非眼科医生和验光师对糖尿病视网膜病变的知识、态度和实践：一项范围综述DOI: 10.7759/cureus.105133 ESC Heart Failure IF: 03.700Ahead of Print.No.190Glucagon-Like Peptide-1 Receptor Agonists in Patients with Heart Failure with Reduced Ejection Fraction胰高血糖素样肽-1受体激动剂在射血分数降低的心力衰竭患者中的研究DOI: 10.1093/eschf/xvag111 EJHF IF: 10.800Ahead of Print.No.191Hemodynamic Changes in Response to GLP-1 Treatment in ICD and CRT Patients: Insights From HeartLogic Sensor Data胰高血糖素样肽-1治疗对ICD和CRT患者的血流动力学变化：来自HeartLogic传感器数据的见解DOI: 10.1093/ejhf/xuag114 JHLT IF: 06.000Volume 45, Issue 5, Page 719-906, A1No.192Metabolic Syndrome and Its Impact on Outcomes After Lung Transplantation代谢综合征及其对肺移植后结局的影响DOI: 10.1016/j.healun.2026.02.1619 bioRxivVolume 2026, Issue No.193A conserved peptidase governs glucose homeostasis in Bacteroides拟杆菌中一种保守肽酶调控葡萄糖稳态DOI: 10.64898/2026.04.10.717545 Curēus IF: 01.300Volume 18, Issue 3No.194Idiopathic Intracranial Hypertension Without Papilledema in a Transgender Woman With HIV: A Case Report and Review of Risk FactorsHIV阳性跨性别女性的无视乳头水肿特发性颅内高压：病例报告及危险因素回顾DOI: 10.7759/cureus.105116 BMC medicine IF: 08.300Volume 24, Issue 1No.195Genetic predisposition to high BMI, ultra-processed food consumptions in childhood, and adiposity in young adulthood: a 17-year prospective cohort study of 3061 individuals儿童期高体重指数遗传易感性、超加工食品摄入与青年期肥胖的17年前瞻性队列研究（3061名个体）DOI: 10.1186/s12916-026-04764-5 Archives of toxicology IF: 06.900Ahead of Print.No.196Therapeutically relevant rimonabant exposure drives epigenetic remodeling in neuronal cells and rat brain tissue治疗相关的利莫那班暴露在神经元细胞和大鼠脑组织中驱动表观遗传重塑DOI: 10.1007/s00204-026-04369-0 Obesity surgery IF: 03.100Ahead of Print.No.197Prophylactic Tranexamic Acid as Prevention for Early Postoperative Bleeding after Roux-en-Y Gastric Bypass氨甲环酸预防Roux-en-Y胃旁路术后早期出血DOI: 10.1007/s11695-026-08658-6 Obesity surgery IF: 03.100Ahead of Print.No.198Prioritizing Clinically Relevant Criteria for Longitudinal Obesity Management: A Systemic Framework to Support Decision-Making纵向肥胖管理中优先考虑临床相关标准：支持决策的系统框架DOI: 10.1007/s11695-026-08652-y Biogerontology IF: 04.100Volume 27, Issue 3No.199Dietary unsaturated fatty acids distinctly associate with the early age sleep-wake cycle and gut integrity in aged fruit flies, Drosophila melanogaster饮食不饱和脂肪酸与老年果蝇（黑腹果蝇）早期睡眠-觉醒周期和肠道完整性的显著关联DOI: 10.1007/s10522-026-10434-z J Autism Dev Disord IF: 02.800Ahead of Print.No.200Chronic Disease Incidence and Onset in Adults With Autism Spectrum Disorder: A 26-Year Matched Cohort Study自闭症谱系障碍成人慢性病发病率与发病情况：一项26年配对队列研究DOI: 10.1007/s10803-026-07282-8 Experimental brain research IF: 01.600Volume 244, Issue 5No.201How does body mass influence inhibitory control? Event-related potentials evidence across the full BMI spectrum体重如何影响抑制控制？全BMI谱的事件相关电位证据DOI: 10.1007/s00221-026-07292-z Aesthetic plastic surgery IF: 02.800Ahead of Print.No.202Outcomes of Body Contouring Surgery After Bariatric Surgery vs. GLP-1 Receptor Agonist-Induced Weight Loss: A Propensity Score Matched Analysis减重手术后的体型塑造手术与GLP-1受体激动剂诱导减重的结果比较：一项倾向得分匹配分析DOI: 10.1007/s00266-026-05861-9 Eur J Orthop Surg Traumatol IF: 01.500Volume 36, Issue 1No.203Metformin use and outcomes after arthroscopic full thickness rotator cuff repair: a real-world, propensity score-matched cohort study二甲双胍使用与关节镜下全层肩袖修复术后结局：一项真实世界、倾向评分匹配队列研究DOI: 10.1007/s00590-026-04754-6 Naunyn Schmiedebergs Arch Pharmacol IF: 03.100Ahead of Print.No.204Zingerone as a neuroprotective agent in experimental diabetes: evidence from oxidative stress, inflammatory, and apoptotic markers姜辣素作为实验性糖尿病中的神经保护剂：来自氧化应激、炎症和凋亡标志物的证据DOI: 10.1007/s00210-026-05268-y Clinical epigenetics IF: 04.400Volume 18, Issue 1No.205Early blood DNA methylation patterns associated with glycemic progression in a prospective Indian cohort前瞻性印度队列中与血糖进展相关的早期血液DNA甲基化模式DOI: 10.1186/s13148-026-02064-6 Metabolic brain disease IF: 03.500Volume 41, Issue 1No.206Association of Wnt1, PORCN, RSPO2 and neuroinflammation with cognitive impairment, depression and quality of life in type 2 diabetes mellitus: a case-control studyWnt1、PORCN、RSPO2及神经炎症与2型糖尿病中认知障碍、抑郁和生活质量的关联：一项病例对照研究DOI: 10.1007/s11011-026-01842-8 International journal of obesity IF: 03.800Ahead of Print.No.207Childhood adversity and gestational diabetes: examining the mediating effect of BMI and depression through interventional mediation analysis童年逆境与妊娠糖尿病：通过干预中介分析考察体重指数和抑郁的中介效应DOI: 10.1038/s41366-026-02080-9 Curēus IF: 01.300Volume 18, Issue 3No.208An Observational Study to Evaluate Dry Eye Status in Type 2 Diabetes Mellitus Patients and Its Association With Diabetic Retinopathy2型糖尿病患者干眼症状态及其与糖尿病视网膜病变相关性的观察性研究DOI: 10.7759/cureus.105279 Pak J Med Sci IF: 01.700Volume 42, Issue 3No.209Quality of Life in relation to Vitamin-D levels in asymptomatic young health care professionals in a tertiary care hospital: Quality of Life and Vitamin-D (QoLD) study三级医院无症状年轻医护人员的生活质量与维生素D水平的关系：生活质量与维生素D（QoLD）研究DOI: 10.12669/pjms.42.3.11603 Rheumatology IF: 04.400Ahead of Print.No.210A rare JAK2 mutation associated with adult-onset Still's disease and exacerbated vaccine-induced innate immune response与成人起病型斯蒂尔病相关的罕见JAK2突变及疫苗诱导的先天免疫反应加剧DOI: 10.1093/rheumatology/keag207 Recent patents on biotechnologyVolume 20, Issue 3No.211Unveiling the Modern Therapeutic Properties and Folk Medicinal Riches of Rubia cordifolia茜草（Rubia cordifolia）的现代治疗特性与民间药用财富揭秘DOI: 10.2174/0118722083359338250611055647 Clinical epigenetics IF: 04.400Volume 18, Issue 1No.212Ultra-mild bisulphite sequencing for DNA methylation analysis from low-input clinical specimens用于低输入量临床样本DNA甲基化分析的超温和亚硫酸氢盐测序DOI: 10.1186/s13148-026-02110-3 BMC health services research IF: 03.000Ahead of Print.No.213Exploring implementation and sustainability of a community paramedicine model to reduce hospitalizations: a pragmatic randomized trial探索社区医护人员模式减少住院的实施与可持续性：一项务实的随机试验DOI: 10.1186/s12913-026-14532-z Eye IF: 03.200Ahead of Print.No.214Diabetes and uveitis. A large cohort evaluation of the association between glycaemic control and incident undifferentiated anterior uveitis. (The DULCE Study)糖尿病与葡萄膜炎：大型队列研究评估血糖控制与新发未分化型前葡萄膜炎的关联（DULCE研究）DOI: 10.1038/s41433-026-04464-7 Advances in therapy IF: 04.000Ahead of Print.No.215Glucagon-Like Peptide-1 Receptor Agonists: Their Therapeutic Potential in Cystic Fibrosis胰高血糖素样肽-1受体激动剂：它们在囊性纤维化中的治疗潜力DOI: 10.1007/s12325-026-03599-z Nature aging IF: 19.400Ahead of Print.No.216p21(+)TREM2(+) senescent macrophages fuel inflammaging and metabolic dysfunction-associated steatotic liver diseasep21阳性TREM2阳性衰老巨噬细胞驱动炎性衰老与代谢功能障碍相关脂肪性肝病DOI: 10.1038/s43587-026-01101-6 Jpn J Ophthalmol IF: 01.900Ahead of Print.No.217Evaluation of objective ocular cyclodeviation according to age, sex, and eye side根据年龄、性别和眼侧评估客观眼球旋转偏斜DOI: 10.1007/s10384-026-01349-w Japanese journal of radiology IF: 04.100Ahead of Print.No.218Imaging findings of diabetic complications from head to toe: a comprehensive radiologic review糖尿病并发症的影像学表现：从头到脚的全面放射学综述DOI: 10.1007/s11604-026-01988-6 J Racial Ethn Health Disparities IF: 02.400Ahead of Print.No.219Examining Racial and Ethnic Disparities in Low-Risk Cesarean Section Deliveries in the Colorado Healthy Start Study科罗拉多州健康起步研究中低风险剖宫产分娩的种族和族裔差异DOI: 10.1007/s40615-025-02808-9 J Endocrinol Invest IF: 03.500Ahead of Print.No.220Adverse effect of age on pancreatic islet morphology, islet cell turnover and lineage-labelled hormone expression in mice年龄对小鼠胰腺胰岛形态、胰岛细胞更新和谱系标记激素表达的不良影响DOI: 10.1007/s40618-026-02884-6 Hypertension Research IF: 04.600Ahead of Print.No.221Effects of tirzepatide, a dual GIP and GLP-1 receptor agonist, on blood pressure, cardiac function, and sympathetic nervous system in stroke-prone spontaneously hypertensive rats双效GIP和GLP-1受体激动剂替尔泊肽对卒中易感性自发性高血压大鼠的血压、心脏功能和交感神经系统的影响DOI: 10.1038/s41440-026-02632-6 Curēus IF: 01.300Volume 18, Issue 3No.222Collaborative Management of Opioid Use Disorder and Cancer Care in a Patient With Medical Complexity and Housing Instability多学科管理一名患有阿片类药物使用障碍、晚期癌症和无家可归的患者：一例报告DOI: 10.7759/cureus.105337 The journal of neuroscience : IF: 04.000Volume 46, Issue 15No.223GABA and Glx Distinctively Predict Motor Learning and Retention in Young and Older Adultsγ-氨基丁酸（GABA）和谷氨酸谷氨酰胺（Glx）独特预测年轻人和老年人的运动学习与保持DOI: 10.1523/JNEUROSCI.1440-25.2026 134 Diabetes Mellitus(DM) 糖尿病 99 Obesity 肥胖症 65 Insulin 胰岛素 23 Type 2 diabetes mellitus(T2DM) 2型糖尿病 13 Diabetic Retinopathy 糖尿病视网膜病 12 Metformin 二甲双胍 9 Semaglutide 司美格鲁肽 9 Type 1 diabetes mellitus(T1DM) 1型糖尿病 8 Metabolic Syndrome 代谢综合征 7 Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA) 胰高血糖素样肽-1受体激动剂 5 Hypoglycemic Agents 降糖药 5 Liraglutide 利拉鲁肽 5 Diabetic Foot 糖尿病足 5 Diabetic Kidney Disease(DKD) 糖尿病肾脏病 4 Diabetes Complications 糖尿病并发症 4 Gabapentin 加巴喷丁 4 Tirzepatide 替尔泊肽 4 Gestational Diabetes Mellitus(GDM) 妊娠糖尿病 3 Pregabalin 普瑞巴林 3 Diabetic acidosis 糖尿病性酸中毒 2 Dapagliflozin 达格列净 2 Empagliflozin 恩格列净 2 gamma-Aminobutyric Acid(GABA) γ-氨基丁酸 2 Dulaglutide 度拉糖肽 1 Exenatide 艾塞那肽 1 Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i) 钠-葡萄糖协同转运蛋白2抑制剂 1 Canagliflozin 卡格列净 1 Lixisenatide 利司那肽 1 Diabetic Peripheral Neuropathy(PDN) 糖尿病周围神经病变 1 Ertugliflozin 艾托格列净 1 Diabetic Cardiomyopathies 糖尿病心肌病 1 Diabetic Neuropathies 糖尿病性神经病变 编辑：牛祥 审校：牛祥