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更新于：2026-04-03
Canagliflozin Hemihydrate
卡格列净
更新于：2026-04-03
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 美国 (2013-03-29), |
最高研发阶段(中国)批准上市 |
特殊审评优先审评 (中国) |
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结构/序列
分子式C48H52F2O11S2 |
InChIKeyVHOFTEAWFCUTOS-TUGBYPPCSA-N |
CAS号928672-86-0 |
关联
216
项与 卡格列净 相关的临床试验ChiCTR2600118444
Study on the impact of Canagliflozin combined with chemotherapy on the outcomes of patients with pulmonary tuberculosis and diabetes mellitus comorbidity
开始日期2026-02-15 |
申办/合作机构- |
NCT06913647
Effect of Canagliflozin on Ultrafiltration and Fibrosis in Peritoneal Dialysis: a a Proof-of-concept Randomized Phase II Crossover Clinical Trial
This is a phase II, proof-of-concept, placebo-controlled, double-blind, cross-over randomized clinical trial, assessing the effect of canagliflozin on peritoneal membrane function in patients on PD.
The primary aim of this trial is to determine the short-term effects of canagliflozin, an SGLT-2 inhibitor, on glucose absorption by the peritoneal membrane and on ultrafiltration, as assessed by a standardized peritoneal equilibrium test. The secondary aims are to determine the effect of canagliflozin on solute clearance and on effluent biomarkers of inflammation, angiogenesis, and fibrosis at 26 weeks. We hypothesize that canagliflozin will prevent glucose absorption by the peritoneal membrane, as compared with placebo, and will attenuate the development of inflammation, angiogenesis, and fibrosis of the peritoneal membrane, as assessed by relevant biomarkers in the dialysate.
The primary aim of this trial is to determine the short-term effects of canagliflozin, an SGLT-2 inhibitor, on glucose absorption by the peritoneal membrane and on ultrafiltration, as assessed by a standardized peritoneal equilibrium test. The secondary aims are to determine the effect of canagliflozin on solute clearance and on effluent biomarkers of inflammation, angiogenesis, and fibrosis at 26 weeks. We hypothesize that canagliflozin will prevent glucose absorption by the peritoneal membrane, as compared with placebo, and will attenuate the development of inflammation, angiogenesis, and fibrosis of the peritoneal membrane, as assessed by relevant biomarkers in the dialysate.
开始日期2026-02-01 |
CTIS2025-522742-46-00
CANIDIAP; CANagliflozin In DIAlysis Patients
开始日期2026-02-01 |
100 项与 卡格列净 相关的临床结果
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100 项与 卡格列净 相关的转化医学
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100 项与 卡格列净 相关的专利（医药）
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1,712
项与 卡格列净 相关的文献（医药）2026-06-01·International journal of cardiology. Cardiovascular risk and prevention
Renal and cardiovascular effects of SGLT2 inhibitors among hypertensive patients with chronic kidney disease: A systematic review and meta-analysis
Review
作者: Danny, Siska Suridanda ; Kuncoro, Brm Ario Suryo ; Amalia, Fauqi ; Kosen, Yosua Darmadi ; Pintaningrum, Yusra ; Dharma, Ahmad Surya ; Javier, R Mohamad ; Faizin, Iqbal ; Fiohana, Puput ; Nurpradika, Brianka Yudha ; Firasghani, Muhammad Almy ; Kurniawan, Kristian ; Puspitasari, Renny Anggraeni ; Andiani ; Samudra, Dian
Background:
Chronic kidney disease (CKD) is frequently complicated by hypertension, a dual contributor to disease progression and cardiovascular risk. Despite standard therapy with renin-angiotensin-aldosterone system inhibitors, residual risk remains high. Sodium-glucose cotransporter-2 (SGLT2) inhibitors have emerged as a novel therapy with proven renal and cardiovascular benefits, but their effects in hypertensive CKD patients remain less well defined.
Methods:
We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) that evaluated SGLT2 inhibitors in CKD patients with baseline systolic blood pressure ≥140 mmHg or renovascular disease. PubMed, Embase, and Cochrane Library were searched from inception to August 2024. Eligible RCTs compared an SGLT2 inhibitor versus placebo and reported outcomes in hypertensive subgroups. Primary outcome was a composite of kidney failure, sustained decline in estimated glomerular filtration rate (eGFR ≥40-50 %), or cardiovascular death. Secondary outcomes included kidney-specific endpoints, cardiovascular composite outcomes, and serious adverse events (SAEs). Pooled odds ratios (ORs) were calculated using random-effects models.
Results:
Three RCTs were included: CREDENCE (canagliflozin), DAPA-CKD (dapagliflozin), and EMPA-KIDNEY (empagliflozin), encompassing 5436 hypertensive participants. For the primary outcome, SGLT2 inhibitors reduced risk compared with placebo (OR 0.76, 95 % CI 0.65-0.88). Kidney outcomes showed consistent benefit (OR 0.70, 95 % CI 0.58-0.85). Cardiovascular events were modestly reduced (OR 0.79, 95 % CI 0.64-0.97). SAEs were slightly lower with SGLT2 inhibitors (OR 0.85, 95 % CI 0.74-0.96). Overall certainty of evidence was graded as moderate.
Conclusions:
Among hypertensive patients with CKD, SGLT2 inhibitors significantly reduce renal disease progression and cardiovascular events while maintaining favorable safety. These findings support their integration into standard therapy for this high-risk population.
2026-04-01·CURRENT PHARMACEUTICAL DESIGN
Inclusion Complexes of α and β -cyclodextrin with Canagliflozin Hemihydrate: Design and Characterization
Article
作者: Sagdeo, Archna ; Gupta, Mukul ; Semalty, Ajay ; Pandey, Mukesh ; Chitra ; Gauniya, Priyanka ; Radheshyam ; Semalty, Mona
Introduction::
Canagliflozin hemihydrate (CANA), an antidiabetic drug that functions as a sodiumglucose
co-transporter 2 (SGLT2) inhibitor, is classified under the Biopharmaceutical Classification System
(BCS) as a Class IV drug, characterized by low solubility and low permeability. This study aimed to enhance
the solubility, dissolution, and permeability of CANA by preparing its inclusion complexes with α-
cyclodextrin (α-CD) and β-cyclodextrin (β-CD), followed by characterization of their crystalline and biopharmaceutical
properties.
Methods::
The solubility of CANA in aqueous medium and phase solubility with α and β-cyclodextrin were
conducted. The inclusion complexes in different CANA: α-CD ratios (1:0.25 to 1:6 mM) and CANA: β-CD
ratios (1:0.50 to 1:8 mM) were prepared using the freeze-drying method. The complexes were subjected to
drug content analysis, Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRPD), angle-
dispersive X-ray diffraction (ADXRD), in vitro dissolution, and permeation studies.
Results::
Phase solubility study indicated significant improvements in aqueous solubility of CANA with α-CD
and β-CD. The solubility of CANA increased significantly (more than 100-fold in BCD8 with 0.577 mg/mL)
upon complexation. BCD8 (1:7) with 97.366% and ACD6 (1:4) with 94.6% showed the highest % drug content.
FTIR confirmed interactions between CANA and CDs due to the disappearance or shifting of some characteristic
peaks (e.g., 3390.68 to 3268.91 cm-1 and 1078.07 to 1024.06 cm-1 in ACD6, while 3265.05 to
3268.91 cm⁻¹ and 1025.99 to 1024.06 cm⁻¹ in ACD7).
Discussion::
XRPD and ADXRD showed the crystalline nature of CANA and CDs, while the complexes exhibited
amorphization with diffused peaks. The lowest crystallite size was observed in ACD6 (449.688) and
the highest in ACD3 (966.936 Å). D-spacing was found to be smallest in ACD8 (0.722 Å) and BCD6 (4.080
Å), and the highest in ACD1 (7.276 Å), BCD7, and BCD8 (7.063 Å). The drug release ranged from 64.265%
(ACD3) to 94.306% (BCD7) and increased with lower crystallinity. ACD8 (87.33%) and BCD7 (93.41%) exhibited
the highest % of drug permeability.
Conclusion::
Inclusion complexation with α-CD and β-CD significantly improved the solubility and dissolution
of CANA in aqueous medium. These findings suggest that cyclodextrin-based inclusion complexes offer
a promising approach to enhancing the biopharmaceutical performance of poorly soluble drugs, such as
CANA.
2026-04-01·CURRENT PROBLEMS IN CARDIOLOGY
NRF2-mediated anti-ferroptotic pathways in diabetic cardiomyopathy: Mechanistic insights, therapeutic advances, and challenges in cardiovascular protection
Review
作者: Al-Doaiss, Amin A ; Halawi, Mustafa H ; Thornbury, William ; Almehmadi, Mazen ; Khan, Shahid Ullah ; Alsyaad, Khalid M ; Ahmed, Ahmed Ezzat ; Ibrahim, Essam H ; Taha, Ramadan
Diabetic cardiomyopathy (DCM) remains a major contributor to cardiovascular morbidity and mortality, yet its underlying mechanisms extend beyond hyperglycemia-induced metabolic stress. Emerging evidence identifies ferroptosis, a regulated, iron-dependent lipid peroxidation process, as a central driver of diabetic myocardial injury. This review synthesizes molecular insights demonstrating how chronic hyperglycemia, oxidative stress, and mitochondrial dysfunction create a uniquely ferroptosis-prone cardiac environment. Particular emphasis is placed on the NRF2 signaling network, which orchestrates antioxidant defense through the HO-1 pathway and the SLC7A11-GSH-GPX4 axis. Diabetic impairment of AMPK/AKT-dependent NRF2 activation compromises these protective systems, accelerating lipid peroxidation, mitochondrial damage, inflammation, and cardiomyocyte death. We further evaluate emerging pharmacologic and natural NRF2 activators, including sulforaphane, curcumin, dexmedetomidine, canagliflozin, and 6-gingerol, demonstrating consistent cardioprotective, anti-ferroptotic benefits in preclinical models. Despite encouraging progress, concerns regarding long-term NRF2 overstimulation, metabolic reprogramming, and oncogenic risk underscore the need for carefully optimized therapeutic strategies. By integrating mechanistic advances with translational challenges, this review highlights NRF2-ferroptosis modulation as a promising frontier for targeted DCM therapy and future precision cardiology.
300
项与 卡格列净 相关的新闻（医药）2026-04-01
前200位的药物PS：两份海报数据由亚利桑那大学统计，因不同机构可能使用不同的数据来源，例如制药公司报告、第三方市场分析、处方数据、不同地区的销售数据以及受各个国家汇率波动的影响，可能导致海报的销售数据与其他机构分析有所不同。TOP1Keytruda（Pembrolizumab）适应症：黑色素瘤、非小细胞肺癌、头颈癌、经典霍奇金淋巴瘤、原发性纵隔大B细胞淋巴瘤、膀胱癌、微卫星高度不稳定或错配修复缺陷癌症、胃癌、食道癌、宫颈癌、肝癌、胆道癌、默克尔细胞癌、肾癌、子宫内膜癌、高肿瘤突变负荷癌、皮肤鳞状细胞癌、三阴性乳腺癌等，其适应症范围仍在继续扩大中。简介Keytruda（Pembrolizumab，帕博利珠单抗）是一种PD-1抑制剂，同时也是目前畅销的抗癌药物TOP1，相比于2022年，其销售额增长了21%。Pembrolizumab是一种高度选择性的IgG4-kappa型人源化单克隆抗体，靶向PD-1受体。它通过将具有极高亲和力的PD-1抗体的可变序列嫁接到含有稳定性S228PFc突变的人IgG4-κ同种型上生成。Pembrolizumab包含32个半胱氨酸残基，完整折叠的分子包括4个作为链间键的二硫键和23个链内键。该药由默克公司开发，于2014年9月4日首次获得FDA批准用于治疗转移性恶性黑色素瘤，成为首个获得批准的PD-1治疗药物。自首次批准以来，Pembrolizumab已被批准用于治疗多种癌症。TOP2Eliquis（Apixaban）简介Eliquis（Apixaban，阿哌沙班）是一种抗凝血药物，可有效预防和治疗血栓，已获得中国、美国、加拿大等45个国家的销售权，是一款推荐级别较高的口服抗凝药物。也是2023年销售额最高的小分子药物。Apixaban作为一种口服、直接且高度选择性的Xa因子（FXa）抑制剂，能够独立于抗凝血酶III抑制游离和结合的FXa以及凝血酶原酶，用于预防和治疗血栓栓塞性疾病。该药物以商品名Eliquis销售。2011年5月，欧洲的食品药品监管（EMA）正式批准Apixaban（Eliquis）用于择期膝/髋关节置换术患者的VTE预防，并于2012年首次获得FDA批准。TOP3Ozempic（Semaglutide）简介由Semaglutide（司美格鲁肽）掀起的减肥风暴席卷全球，也引起了GLP-1药物的研发热潮。Semaglutide在2023的销量相较于2022年激增90%，并且有望在今年竞争TOP1销量药物的宝座。Semaglutide是一种类胰高血糖素样肽1（GLP-1）类似物，可通过与GLP-1受体结合并激活其功能，从而刺激胰岛素分泌，降低血糖水平，主要用于管理2型糖尿病。该药物类别的其他成员包括艾塞那肽（Exenatide）和利拉鲁肽（Liraglutide）。Semaglutide于2017年12月获得FDA批准用于皮下注射。该药物的片剂制剂于2019年9月获得口服给药的批准。2021年6月，FDA批准Semaglutide用于治疗成年人的体重管理，这是自2014年以来首个获得批准用于此类用途的药物，后续也获得了加拿大卫生部（HealthCanada）和EMA的批准。TOP4Humira（Adalimumab）简介Humira（Adalimumab，阿达木单抗）是一种特异性靶向人TNF-α的全人重组IgG1单克隆抗体。曾是世界上最畅销的处方药。Adalimumab可特异性地与TNF-α结合并阻断其与p55和p75细胞表面TNF受体的相互作用，用以治疗类风湿关节炎、强直性脊柱炎等疾病。2002年获FDA批准上市，从2005年的年销售额10亿美元到年销售额30亿美元只用了两年的时间，是比较受欢迎的抗自身免疫药物之一。TOP5Bikatarvy（Bictegravir/Emtricitabine/TenofovirAlafenamide）简介在HIV销售药物方面，几乎没有任何产品能与吉利德公司的Bikatarvy（Bictegravir/Emtricitabine/TenofovirAlafenamide）相提并论。Biktarvy（必妥维）用于治疗人类免疫缺陷病毒1型（HIV-1）感染的成人，且患者无对整合酶抑制剂类药物、恩曲他滨或替诺福韦产生病毒耐药。于2018年2月获得美国FDA批准率先在美国上市，2019年8月，该药凭借“防治艾滋病且具有明显临床优势”获得国家药监局批准在国内上市。TOP6Dupixent（Dupilumab）简介Dupixent（Dupilumab，度普利尤单抗）是一种完全人源化的免疫球蛋白G4亚类单克隆抗体，它结合于白细胞介素-4（IL-4）受体，从而抑制该受体的信号传导通路。作为一种白细胞介素-4受体α拮抗剂，dupilumab抑制促炎性细胞因子（称为白细胞介素）的信号传导，这些细胞因子在多种特应性或过敏性疾病（如湿疹、过敏反应和鼻窦炎）中引发炎症和免疫反应。Dupilumab于2017年首次获得FDA批准。它可以作为单药治疗或与其他药物（如皮质类固醇）联合使用。Dupilumab目前正在研究其在由过敏反应或2型炎症驱动的疾病（如儿童特应性皮炎和慢性阻塞性肺疾病）中的潜在治疗用途。此外，它还在研究与另一种靶向IL-33的抗体联合使用。TOP7Stelara（Ustekinumab）简介Stelara（Ustekinumab，乌司奴单抗）目前是第一个也是唯一一个被批准用于溃疡性结肠炎的靶向IL-12和IL-23细胞因子的生物疗法。Ustekinumab是一种人免疫球蛋白(Ig)G1kappa单克隆抗体，用于管理多种涉及IL-12和IL-23信号通路激活的炎症性疾病。该药物的治疗用途始于2009年，当时在加拿大、美国和欧洲首次批准用于治疗中度至重度斑块型银屑病和活动性银屑病关节炎的成人患者。2016年9月，Ustekinumab进一步被批准用于管理特定成人患者的中度至重度克罗恩病。2019年10月，FDA还批准其用于管理成人中度至重度活动性溃疡性结肠炎。TOP8Comirnaty简介2021年，Comirnaty的销售额为368亿美元，2022年，其销售额达到378亿美元。2023年，随着新冠大流行的结束，对疫苗的需求直线下降，其销售额降低至112亿美元。Comirnaty是一种用于主动免疫的疫苗，用于预防由16岁及以上的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的2019年冠状病毒病（COVID-19）。FDA于2021年8月23日正式批准辉瑞-拜恩泰科新冠疫苗Comirnaty上市。TOP9Jardiance（Empagliflozin）简介Jardiance（Empagliflozin，恩格列净）是欧洲和加拿大首个也是唯一一个批准用于治疗所有射血分数症状性慢性心力衰竭成年患者的药物。1835年，从苹果树皮中首次分离出SGLT的抑制剂phlorizin，并在20世纪进行了广泛研究，但由于其缺乏特异性和显著的胃肠道副作用，最终被认为不适合临床使用。为了克服这些限制，首先开发了phlorizin的O-葡萄糖苷类似物，但这些分子在药代动力学上相对不稳定。C-葡萄糖苷phlorizin类似物的发展解决了上一代分子观察到的问题，并导致FDA在2013年批准了canagliflozin，在2014年批准了dapagliflozin和empagliflozin。作为最近批准的“flozin”类药物，empagliflozin对SGLT2的选择性最高，约为SGLT1的2700倍。Empagliflozin还于2022年3月获得欧洲药品管理局（EMA）的批准，并于2022年4月获得加拿大卫生部的批准。TOP10Opdivo（Nivolumab）简介Opdivo（Nivolumab，纳武利尤单抗）和Keytruda同属于PD-1抑制剂，于2014年12月22日首次获得FDA批准。Nivolumab与PD-1结合，防止PD-L1和PD-L2抑制T细胞的作用，从而恢复患者的肿瘤特异性T细胞反应。Nivolumab完全在小鼠体内生产，并移植到人类kappa和IgG4Fc区域上，并通过S228P突变提高了稳定性和减少了变异。当与顺铂和吉西他滨联合使用时，nivolumab适用于成人不可切除或转移性尿路上皮癌患者的一线治疗。TargetMol-盘点:全球热销药物TOP200前200位的药物PS：两份海报数据由亚利桑那大学统计，因不同机构可能使用不同的数据来源，例如制药公司报告、第三方市场分析、处方数据、不同地区的销售数据以及受各个国家汇率波动的影响，可能导致海报的销售数据与其他机构分析有所不同。TOP1Keytruda（Pembrolizumab）适应症：黑色素瘤、非小细胞肺癌、头颈癌、经典霍奇金淋巴瘤、原发性纵隔大B细胞淋巴瘤、膀胱癌、微卫星高度不稳定或错配修复缺陷癌症、胃癌、食道癌、宫颈癌、肝癌、胆道癌、默克尔细胞癌、肾癌、子宫内膜癌、高肿瘤突变负荷癌、皮肤鳞状细胞癌、三阴性乳腺癌等，其适应症范围仍在继续扩大中。简介Keytruda（Pembrolizumab，帕博利珠单抗）是一种PD-1抑制剂，同时也是目前畅销的抗癌药物TOP1，相比于2022年，其销售额增长了21%。Pembrolizumab是一种高度选择性的IgG4-kappa型人源化单克隆抗体，靶向PD-1受体。它通过将具有极高亲和力的PD-1抗体的可变序列嫁接到含有稳定性S228PFc突变的人IgG4-κ同种型上生成。Pembrolizumab包含32个半胱氨酸残基，完整折叠的分子包括4个作为链间键的二硫键和23个链内键。该药由默克公司开发，于2014年9月4日首次获得FDA批准用于治疗转移性恶性黑色素瘤，成为首个获得批准的PD-1治疗药物。自首次批准以来，Pembrolizumab已被批准用于治疗多种癌症。TOP2Eliquis（Apixaban）简介Eliquis（Apixaban，阿哌沙班）是一种抗凝血药物，可有效预防和治疗血栓，已获得中国、美国、加拿大等45个国家的销售权，是一款推荐级别较高的口服抗凝药物。也是2023年销售额最高的小分子药物。Apixaban作为一种口服、直接且高度选择性的Xa因子（FXa）抑制剂，能够独立于抗凝血酶III抑制游离和结合的FXa以及凝血酶原酶，用于预防和治疗血栓栓塞性疾病。该药物以商品名Eliquis销售。2011年5月，欧洲的食品药品监管（EMA）正式批准Apixaban（Eliquis）用于择期膝/髋关节置换术患者的VTE预防，并于2012年首次获得FDA批准。TOP3Ozempic（Semaglutide）简介由Semaglutide（司美格鲁肽）掀起的减肥风暴席卷全球，也引起了GLP-1药物的研发热潮。Semaglutide在2023的销量相较于2022年激增90%，并且有望在今年竞争TOP1销量药物的宝座。Semaglutide是一种类胰高血糖素样肽1（GLP-1）类似物，可通过与GLP-1受体结合并激活其功能，从而刺激胰岛素分泌，降低血糖水平，主要用于管理2型糖尿病。该药物类别的其他成员包括艾塞那肽（Exenatide）和利拉鲁肽（Liraglutide）。Semaglutide于2017年12月获得FDA批准用于皮下注射。该药物的片剂制剂于2019年9月获得口服给药的批准。2021年6月，FDA批准Semaglutide用于治疗成年人的体重管理，这是自2014年以来首个获得批准用于此类用途的药物，后续也获得了加拿大卫生部（HealthCanada）和EMA的批准。TOP4Humira（Adalimumab）简介Humira（Adalimumab，阿达木单抗）是一种特异性靶向人TNF-α的全人重组IgG1单克隆抗体。曾是世界上最畅销的处方药。Adalimumab可特异性地与TNF-α结合并阻断其与p55和p75细胞表面TNF受体的相互作用，用以治疗类风湿关节炎、强直性脊柱炎等疾病。2002年获FDA批准上市，从2005年的年销售额10亿美元到年销售额30亿美元只用了两年的时间，是比较受欢迎的抗自身免疫药物之一。TOP5Bikatarvy（Bictegravir/Emtricitabine/TenofovirAlafenamide）简介在HIV销售药物方面，几乎没有任何产品能与吉利德公司的Bikatarvy（Bictegravir/Emtricitabine/TenofovirAlafenamide）相提并论。Biktarvy（必妥维）用于治疗人类免疫缺陷病毒1型（HIV-1）感染的成人，且患者无对整合酶抑制剂类药物、恩曲他滨或替诺福韦产生病毒耐药。于2018年2月获得美国FDA批准率先在美国上市，2019年8月，该药凭借“防治艾滋病且具有明显临床优势”获得国家药监局批准在国内上市。TOP6Dupixent（Dupilumab）简介Dupixent（Dupilumab，度普利尤单抗）是一种完全人源化的免疫球蛋白G4亚类单克隆抗体，它结合于白细胞介素-4（IL-4）受体，从而抑制该受体的信号传导通路。作为一种白细胞介素-4受体α拮抗剂，dupilumab抑制促炎性细胞因子（称为白细胞介素）的信号传导，这些细胞因子在多种特应性或过敏性疾病（如湿疹、过敏反应和鼻窦炎）中引发炎症和免疫反应。Dupilumab于2017年首次获得FDA批准。它可以作为单药治疗或与其他药物（如皮质类固醇）联合使用。Dupilumab目前正在研究其在由过敏反应或2型炎症驱动的疾病（如儿童特应性皮炎和慢性阻塞性肺疾病）中的潜在治疗用途。此外，它还在研究与另一种靶向IL-33的抗体联合使用。TOP7Stelara（Ustekinumab）简介Stelara（Ustekinumab，乌司奴单抗）目前是第一个也是唯一一个被批准用于溃疡性结肠炎的靶向IL-12和IL-23细胞因子的生物疗法。Ustekinumab是一种人免疫球蛋白(Ig)G1kappa单克隆抗体，用于管理多种涉及IL-12和IL-23信号通路激活的炎症性疾病。该药物的治疗用途始于2009年，当时在加拿大、美国和欧洲首次批准用于治疗中度至重度斑块型银屑病和活动性银屑病关节炎的成人患者。2016年9月，Ustekinumab进一步被批准用于管理特定成人患者的中度至重度克罗恩病。2019年10月，FDA还批准其用于管理成人中度至重度活动性溃疡性结肠炎。TOP8Comirnaty简介2021年，Comirnaty的销售额为368亿美元，2022年，其销售额达到378亿美元。2023年，随着新冠大流行的结束，对疫苗的需求直线下降，其销售额降低至112亿美元。Comirnaty是一种用于主动免疫的疫苗，用于预防由16岁及以上的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的2019年冠状病毒病（COVID-19）。FDA于2021年8月23日正式批准辉瑞-拜恩泰科新冠疫苗Comirnaty上市。TOP9Jardiance（Empagliflozin）简介Jardiance（Empagliflozin，恩格列净）是欧洲和加拿大首个也是唯一一个批准用于治疗所有射血分数症状性慢性心力衰竭成年患者的药物。1835年，从苹果树皮中首次分离出SGLT的抑制剂phlorizin，并在20世纪进行了广泛研究，但由于其缺乏特异性和显著的胃肠道副作用，最终被认为不适合临床使用。为了克服这些限制，首先开发了phlorizin的O-葡萄糖苷类似物，但这些分子在药代动力学上相对不稳定。C-葡萄糖苷phlorizin类似物的发展解决了上一代分子观察到的问题，并导致FDA在2013年批准了canagliflozin，在2014年批准了dapagliflozin和empagliflozin。作为最近批准的“flozin”类药物，empagliflozin对SGLT2的选择性最高，约为SGLT1的2700倍。Empagliflozin还于2022年3月获得欧洲药品管理局（EMA）的批准，并于2022年4月获得加拿大卫生部的批准。TOP10Opdivo（Nivolumab）简介Opdivo（Nivolumab，纳武利尤单抗）和Keytruda同属于PD-1抑制剂，于2014年12月22日首次获得FDA批准。Nivolumab与PD-1结合，防止PD-L1和PD-L2抑制T细胞的作用，从而恢复患者的肿瘤特异性T细胞反应。Nivolumab完全在小鼠体内生产，并移植到人类kappa和IgG4Fc区域上，并通过S228P突变提高了稳定性和减少了变异。当与顺铂和吉西他滨联合使用时，nivolumab适用于成人不可切除或转移性尿路上皮癌患者的一线治疗。
上市批准临床3期加速审批
2026-04-01
·肾指导
收到一位患者的留言，吃了大把的药，却搞不清哪个是核心，哪个是辅助，哪个该长期吃，哪个该见好就收！
今天把这些药物整理成一份完整的列表。建议你收藏起来，需要的时候拿出来对照。
RAS抑制剂(普利类/沙坦类)
普利类——贝那普利、培哚普利、雷米普利等。
沙坦类——氯沙坦、缬沙坦、厄贝沙坦、替米沙坦等。
这是肾病治疗的基石，也是最早被证实能延缓肾功能下降的药物。
扩张肾小球出球小动脉，降低肾小球内部压力，减少蛋白漏出，延缓肾小球硬化。
适用所有有蛋白尿的慢性肾脏病患者，不管有没有高血压。
使用RAS抑制剂能让肾功能下降速度减慢30%左右，尿毒症风险降低30%以上。
提示：要用到足量，用到患者能耐受的最大剂量。用药初期肌酐可能会轻微升高，只要不超过30%，不用停药。定期监测血钾、肌酐。
孕妇禁用，双侧肾动脉狭窄者禁用。
SGLT-2抑制剂(列净类)
达格列净、恩格列净、卡格列净。
降低肾小球内部压力，减少肾小管耗氧，抑制肾脏炎症和纤维化，降尿酸、降体重、降血压。
适用肾小球滤过率在30以上的慢性肾脏病患者，不管有没有糖尿病。
2020年DAPA-CKD试验证实，使用SGLT-2抑制剂能让肾功能下降速度减慢40%到50%，尿毒症风险降低30%以上，全因死亡风险降低30%以上。
提示：用药初期滤过率可能暂时下降5-10个点，这是正常现象，后面会稳住。要多喝水，每天1500-2000毫升。注意尿路感染风险。
非奈利酮
这是最新被证实能延缓肾功能下降的药物。
阻断盐皮质激素受体，抑制肾脏炎症和纤维化，降低肾小球内部压力。
适用：肾小球滤过率在25以上的慢性肾脏病患者，尤其适合糖尿病肾病，最新研究证实对非糖尿病肾病也有效。
非奈利酮能显著降低尿蛋白，延缓肾功能下降，安全性良好。
提示：用药期间要监测血钾。与RAS抑制剂、SGLT-2抑制剂联用效果更好。
激素和免疫抑制剂
激素类——泼尼松、甲泼尼龙等。
免疫抑制剂——环磷酰胺、他克莫司、霉酚酸酯、环孢素等。
生物制剂——利妥昔单抗、贝利尤单抗等。
这类药不是所有人都能用，但对免疫系统攻击肾脏的患者来说，它们是“救命药”。
抑制免疫系统对肾脏的攻击，减轻肾脏炎症，降低蛋白尿。
适用：免疫性肾病患者，如IgA肾病(高危型)、膜性肾病、狼疮性肾炎、局灶节段性肾小球硬化(部分类型)、安卡相关性肾炎等。
提示：必须在医生指导下使用，不能自己乱用，也不能自己乱停。注意监测副作用，如感染、血糖升高、骨质疏松等。该用的时候别怕，不该用的时候别乱用。
雷公藤多苷片
抑制T细胞和B细胞的活化，减少炎症因子释放，降低尿蛋白，延缓肾小球硬化。
适用：IgA肾病、膜性肾病、狼疮性肾炎、局灶节段性肾小球硬化等免疫性肾病患者，尤其适合对激素不耐受或激素依赖的患者。
多项临床研究证实，雷公藤多苷能显著降低免疫性肾病患者的尿蛋白，延缓肾功能下降。对于IgA肾病，雷公藤多苷的疗效与激素相当，但副作用谱不同。
提示：有生殖毒性，年轻患者慎用。可能引起肝功能损害、白细胞减少、月经紊乱。用药期间要定期查肝功、血常规。孕妇、哺乳期妇女禁用。
百令胶囊、金水宝胶囊
补肺肾、益精气。研究证实，它们有抗炎、抗纤维化、调节免疫、改善肾小管间质损伤的作用。
适用：各类慢性肾脏病患者，尤其适合有乏力、腰酸、易感冒等虚证表现的患者。可作为辅助治疗，改善症状，提高生活质量。
百令和金水宝能改善肾病患者乏力、腰酸等症状，对延缓肾功能下降有一定辅助作用。但它们不能替代RAS抑制剂、SGLT-2抑制剂等核心治疗。
提示：是辅助用药，不是主力。吃的时候不要停核心药。性质偏温，容易上火的人要慎用。感冒发烧时停用。
尿毒清颗粒、肾衰宁胶囊
通过肠道吸附毒素、促进排便，增加毒素的肠道排泄，从而降低血肌酐、尿素氮。
适用：慢性肾衰竭患者，尤其是肌酐升高、便秘或大便不畅的患者。可作为辅助排毒治疗。
尿毒清和肾衰宁能短期降低血肌酐，改善消化道症状。但它们不能延缓肾小球硬化的进程，不能替代核心治疗。
提示：是辅助排毒药，不是保肾药。不能替代RAS抑制剂、SGLT-2抑制剂等核心治疗。长期使用要监测电解质，防止腹泻导致脱水。肌酐降了不代表肾好了，要看滤过率。
开同(复方α-酮酸)
配合低蛋白饮食，提供必需氨基酸，减少氮质废物生成，减轻肾脏负担。同时纠正氨基酸代谢紊乱，改善营养不良。
适用：慢性肾衰竭患者，尤其是需要低蛋白饮食的患者。配合优质低蛋白饮食使用，效果更好。
开同配合低蛋白饮食，能延缓肾功能下降，改善营养状况，推迟透析时间。
提示：必须在低蛋白饮食的基础上使用，否则没有意义。吃开同的时候，蛋白质摄入要严格控制在每天每公斤体重0.6克以下。不是所有肾病患者都需要吃，要遵医嘱。
碳酸氢钠片(小苏打)
纠正代谢性酸中毒，减轻酸中毒对肾脏的损伤，延缓肾衰竭进展。
适用：慢性肾衰竭合并代谢性酸中毒的患者，血碳酸氢根低于22mmol/L时需要使用。
纠正酸中毒能延缓肾功能下降，改善营养状况，降低死亡率。
提示：要定期查血碳酸氢根，根据结果调整剂量。不是所有肾病患者都需要吃，血碳酸氢根正常的不需要。长期服用要监测血钠、血压。
中医清血清毒
中药外敷、结肠透析、督灸、隔物灸、中药熏洗、药浴、中频脉冲电治疗等。
清理血液环境，清除免疫复合物和炎症因子，活血化瘀，改善肾脏微循环，温通经络，扶助阳气。
适用：各类慢性肾脏病患者，尤其适合在西药治疗基础上，希望通过中医辅助调理、改善症状、稳定肾功能的患者。
如果有肾病方面问题，可添加微信，一对一指导
2026-03-31
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截至03月31日15点59分，近期共有 497 本期刊发布了 1131 篇文章，其中糖尿病相关的文章共 339 篇，覆盖 32 个领域的内容。中国专家参与发表的文章有 86 篇。今日，影响因子最高的文章刊登在 The New England Journal of Medicine (IF: 78.500) 期刊上。
今日头条
Headlines
01 EHJ-QCCO IF: 04.600 GLP-1受体激动剂与减重手术在患有肥厚型心肌病的肥胖患者中的结局比较：一项多中心倾向匹配分析
Mahmoud, Ahmed K, Awad, Kamal, Sheashaa, Hesham, Kandil, Omneya, Farina, Juan M, Ibrahim, Ramzi, etc.
一项多中心倾向匹配分析对比了GLP-1受体激动剂（GLP-1 RA）与减重手术（BS）在患有肥厚型心肌病（HCM）的肥胖患者中的结局差异。
一项多中心倾向匹配分析对比了GLP-1受体激动剂（GLP-1 RA）与减重手术（BS）在患有肥厚型心肌病（HCM）的肥胖患者中的结局差异。
一项多中心倾向匹配分析对比了GLP-1受体激动剂（GLP-1 RA）与减重手术（BS）在患有肥厚型心肌病（HCM）的肥胖患者中的结局差异。
研究纳入5002例符合条件的患者，经1:1倾向匹配后每组955例，平均年龄54±13岁，70%为女性，基线体重指数（BMI）均为40.0 kg/m²。
研究将患者分为两组，一组为从未接受过减重手术的GLP-1 RA使用者，另一组为从未使用过GLP-1 RA的减重手术患者，通过倾向匹配平衡人口统计学特征、合并症及用药情况。随访24个月，评估全因死亡率、急性心力衰竭（HF）住院、心律失常、BMI变化及心血管症状等指标。
结果显示，与减重手术相比，GLP-1 RA治疗在全因死亡率和心力衰竭事件方面表现更优。具体数据显示，GLP-1 RA组全因死亡率为2.0%，显著低于BS组的4.4%（HR=0.46，95%CI 0.27-0.80，P=0.004）；HF住院率GLP-1 RA组为8.7%，低于BS组的14.0%（HR=0.60，95%CI 0.46-0.79，P<0.001）。此外，GLP-1 RA组复合心血管结局发生率（10.7%）显著低于BS组（17.2%）（HR=0.60，95%CI 0.47-0.77，P<0.001）。
BMI变化方面，BS组平均降低4.0 kg/m²，高于GLP-1 RA组的2.6 kg/m²（P<0.001）。但两组在心律失常和心血管症状发生率上无显著差异。
研究结论指出，在患有肥厚型心肌病的肥胖患者中，GLP-1 RA治疗与减重手术相比，全因死亡率和心力衰竭事件风险更低。未来研究需进一步验证这一发现。
本文由 韩玉莲 编辑
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EHJ-QCCO | Ahead of Print.
10.1093/ehjqcco/qcag051
02 Frontiers in immunology IF: 05.900 早晨咖啡摄入时间及其与胰岛素抵抗的关联：来自人类和动物实验的证据
Liu, Peiyan, Yao, Guixiang, Wu, Yixia, Zhou, Qi, etc.
近日，一项发表于Frontiers in Immunology的研究通过对美国国家健康与营养检查调查（NHANES）2005-2018年数据的二次分析及小鼠实验，揭示了咖啡摄入时间对胰岛素抵抗的关键影响。
研究发现，早晨集中摄入咖啡（如上午4:00-11:59 AM）与胰岛素抵抗（通过甘油三酯-葡萄糖指数（TyG）、代谢性胰岛素抵抗指数（METS-IR）、甘油三酯/高密度脂蛋白胆固醇比值（TG/HDL-C）三个指标验证）呈线性负相关，而全天分散摄入咖啡则呈J形关联。
进一步动物实验表明，早晨咖啡摄入可降低高脂饮食诱导的小鼠血糖、胰岛素水平，增强葡萄糖耐受性，并通过抑制促炎因子（如IL-1β、IL-6）改善代谢健康。此外，研究证实炎症因子（白细胞计数、中性粒细胞/淋巴细胞比值）在该关联中起部分中介作用。
进一步动物实验表明，早晨咖啡摄入可降低高脂饮食诱导的小鼠血糖、胰岛素水平，增强葡萄糖耐受性，并通过抑制促炎因子（如IL-1β、IL-6）改善代谢健康。此外，研究证实炎症因子（白细胞计数、中性粒细胞/淋巴细胞比值）在该关联中起部分中介作用。
进一步动物实验表明，早晨咖啡摄入可降低高脂饮食诱导的小鼠血糖、胰岛素水平，增强葡萄糖耐受性，并通过抑制促炎因子（如IL-1β、IL-6）改善代谢健康。此外，研究证实炎症因子（白细胞计数、中性粒细胞/淋巴细胞比值）在该关联中起部分中介作用。
这一发现提示，咖啡摄入时间可能是影响代谢健康的关键因素，早晨集中摄入咖啡或为改善胰岛素抵抗的潜在策略。
这一发现提示，咖啡摄入时间可能是影响代谢健康的关键因素，早晨集中摄入咖啡或为改善胰岛素抵抗的潜在策略。
这一发现提示，咖啡摄入时间可能是影响代谢健康的关键因素，早晨集中摄入咖啡或为改善胰岛素抵抗的潜在策略。
本文由 韩玉莲 编辑
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Frontiers in immunology | Volume 17, Issue
10.3389/fimmu.2026.1775412
03 EJPC IF: 07.500 2型糖尿病成人对有氧运动训练的最大摄氧量峰值（VO2peak）反应性决定因素：PROTECTION研究
Michielsen, Matthijs, Gojevic, Tin, Bekhuis, Youri, Claes, Jomme, Machado, Felipe, Claessen, Guido, etc.
European Journal of Preventive Cardiology在线发表的PROTECTION研究表明，26周中等强度骑行计划可显著改善2型糖尿病（T2D）成人的心肺功能（最大摄氧量峰值VO2peak），但个体反应差异显著，脂肪质量和胰岛素抵抗是关键预测因素。
该研究纳入108例T2D成人参与26周监督下的中等强度骑行训练（3次/周），最终88例完成全程（平均年龄59.8±9.2岁，64%为男性）。结果显示，VO2peak平均提升3.6±2.5 mL/kg/min（增幅17%）。分组分析发现，与无反应者相比，高反应者的脂肪质量更低、胰岛素抵抗更小，且基线体能（心肺功能）也较低。
研究通过单变量和多变量LASSO回归分析，识别出影响VO2peak变化的关键因素：女性性别、吸烟、人体测量指标（如体重/体脂）、胰岛素抵抗及β受体阻滞剂或GLP-1受体激动剂的使用与VO2peak改善负相关；而肺功能、肌肉力量和血红蛋白水平与之正相关。多变量模型进一步证实，脂肪质量（%）和胰岛素抵抗是决定VO2peak反应性的核心基线因素。
研究结论指出，26周中等强度骑行能有效提升T2D成人的心肺功能，但个体反应差异较大。建议在糖尿病（前期）诊断后尽早开展运动干预，并结合改善身体成分的措施，以增强心肺功能的提升效果。
本文由 韩玉莲 编辑
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EJPC | Ahead of Print.
10.1093/eurjpc/zwag150
04 Diabetes, obesity & metabolism IF: 05.700 司美格鲁肽1.7 mg用于青少年肥胖治疗的有效性、安全性和药代动力学：基于模型的药物开发方法
Strathe, Anders, Bomberg, Eric M, Jensch, Garrit, Kildegaard, Jonas, Harder-Lauridsen, Nina M, Weghuber, Daniel, etc.
本研究采用基于模型的药物开发方法（MIDD），结合青少年STEP TEENS 3期研究（N=201）和成人STEP研究（约3100名参与者）数据，分析1.7 mg司美格鲁肽在青少年肥胖治疗中的有效性、安全性和药代动力学特征。研究目的是探索青少年肥胖治疗的低剂量选择，评估1.7 mg剂量与成人及2.4 mg剂量的比较效果。
方法上，研究整合了不同剂量（0.25-2.4 mg）的浓度-时间曲线模型，通过模拟分析青少年与成人的药代动力学（PK）参数差异，同时计算BMI变化百分比，估算达成≥5%、≥10%、≥15% BMI降低的比例，并根据暴露量预测胃肠道不良事件（AE）发生率。主要协变量分析显示体重是影响司美格鲁肽暴露量的关键因素。
结果显示，青少年与成人在68周内的司美格鲁肽浓度模拟值相似，表明青少年无需调整剂量即可维持稳定暴露水平。1.7 mg剂量组青少年的平均BMI变化为-15.2%，与2.4mg剂量组（-17.4%）相当，且显著优于安慰剂（P<0.01）。预设BMI降低阈值（≥5%、≥10%、≥15%）的达成比例在青少年、成人及不同剂量组间均无显著差异，胃肠道不良事件发生率也与剂量和人群特征无关。
该研究证实，药代动力学/药效学（PK/PD）和安全性模型证实1.7 mg司美格鲁肽在青少年中具有与成人及2.4m g剂量相当的暴露量、耐受性及BMI降低效果，这些结果支持2024年11月Wegovy标签批准1.7 mg剂量用于≥12岁青少年肥胖治疗，无需额外开展青少年1.7 mg安慰剂对照试验。
本文由 韩玉莲 编辑
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Diabetes, obesity & metabolism | Ahead of Print.
10.1111/dom.70678
中国发表（86）
China
Eur J Med Chem IF: 05.900Ahead of Print.No.01Synthesis, and pharmacological evaluation of iminoguanidine derivatives: Identification of FuBIG showing protective effects against diabetic neuroinflammation with a favorable lactate metabolism profile咪唑胍衍生物的合成及药理学评价：具有良好乳酸代谢谱的FuBIG对糖尿病神经炎症的保护作用DOI: 10.1016/j.ejmech.2026.118792
Br J Clin Pharmacol IF: 03.000Ahead of Print.No.02Comment on 'Renoprotective effects of dapagliflozin in diabetic patients with chronic kidney disease: A retrospective observational study'评论《达格列净对慢性肾脏病糖尿病患者的肾脏保护作用：一项回顾性观察研究》DOI: 10.1002/bcp.70546
Renal failure IF: 03.000Volume 48, Issue 1No.03Hirsutine mitigates high glucose-induced cell injury via autophagy activation and NRF2/GPX4-mediated ferroptosis inhibition汉防己甲素通过激活自噬和NRF2/GPX4介导的铁死亡抑制减轻高糖诱导的细胞损伤DOI: 10.1080/0886022X.2026.2637325
Scientific reports IF: 03.900Ahead of Print.No.04Non-linear associations between red blood cell distribution width/serum albumin ratio with diabetic kidney disease: results from two nationwide studies in the United States and China红细胞分布宽度/血清白蛋白比率与糖尿病肾病的非线性关联：中美两项全国性研究结果DOI: 10.1038/s41598-026-45999-9
Renal failure IF: 03.000Volume 48, Issue 1No.05ADAMTS13 ameliorates diabetic nephropathy by Nrf2/GPX4/eNOS signaling pathwayADAMTS13通过Nrf2/GPX4/eNOS信号通路改善糖尿病肾病DOI: 10.1080/0886022X.2026.2646089
Cellular signalling IF: 03.700Ahead of Print.No.06E3 ubiquitin ligases and deubiquitinases: Promising therapeutic targets for diabetic kidney diseaseE3泛素连接酶和去泛素化酶：糖尿病肾病的潜在治疗靶点DOI: 10.1016/j.cellsig.2026.112513
Int J Nurs Pract IF: 02.000Volume 32, Issue 2No.07Prevalence of Subthreshold Depression in Patients With Diabetes Mellitus: Systematic Review and Meta-Analysis糖尿病患者阈下抑郁的患病率：系统综述与荟萃分析DOI: 10.1111/ijn.70135
International journal of obesity IF: 03.800Ahead of Print.No.08Genetic evidence for the association between schizophrenia and obesity精神分裂症与肥胖关联的遗传证据DOI: 10.1038/s41366-026-02059-6
Zhonghua yixue zazhiVolume 106, Issue 12No.09[Gender differences in comorbidity characteristics among patients with sudden sensorineural hearing loss]突发性神经性耳聋患者合并症特征的性别差异DOI: 10.3760/cma.j.cn112137-20251128-03115
Scientific reports IF: 03.900Ahead of Print.No.10The association of TyG-BMI with MAFLD and liver fibrosis: a cross-sectional study甘油三酯-血糖-体重指数（TyG-BMI）与代谢相关脂肪肝疾病（MAFLD）及肝纤维化的关联：一项横断面研究DOI: 10.1038/s41598-026-46378-0
Acta pharmacologica Sinica IF: 08.400Ahead of Print.No.11Transcutaneous allicin oleogel restores energy homeostasis for obesity treatment经皮大蒜素油凝胶恢复能量稳态以治疗肥胖DOI: 10.1038/s41401-026-01768-y
J Int Med Res IF: 01.500Volume 54, Issue 3No.12Serum high-density lipoprotein partially mediates the inverted L-shaped association between estimated glucose disposal rate and risk of kidney stones: A cross-sectional study from National Health and Nutrition Examination Survey血清高密度脂蛋白部分介导估计葡萄糖利用率与肾结石风险的倒L形关联：来自美国国家健康与营养检查调查的横断面研究DOI: 10.1177/03000605261431933
PloS one IF: 02.600Volume 21, Issue 3No.13Osteoarthritis in older adults: A global health challenge and the role of high BMI in shaping disease trends老年人骨关节炎：全球健康挑战及高体重指数对疾病趋势的影响DOI: 10.1371/journal.pone.0344284
Circulation IF: 38.600Volume 153, Issue 13No.14Response by Gao et al to Letter Regarding Article, "G Protein-Coupled Receptor Kinase 3 Exacerbates Diabetic Heart Injuries Through Direct Phosphorylation of Cannabinoid Receptor 2 in Humans and Mice"高等人对《G蛋白偶联受体激酶3通过直接磷酸化人及小鼠大麻素受体2加重糖尿病心脏损伤》一文相关来信的回应DOI: 10.1161/CIRCULATIONAHA.125.079055
Gut : IF: 25.800Volume 75, Issue 3No.15Two-step clinical care pathway to predict MASLD-related advanced fibrosis and long-term outcomes in type 2 diabetes两步临床护理路径预测2型糖尿病患者代谢功能障碍相关脂肪性肝病的晚期肝纤维化及长期结局DOI: 10.1136/gutjnl-2025-337506
International immunopharmacology IF: 04.700Ahead of Print.No.16The TGFB1-Wnt/β-catenin axis programs a neuroprotective IGF1(+) microglial state during epileptogenesisTGFB1-Wnt/β-catenin轴在癫痫发生过程中编程神经保护性IGF1(+)小胶质细胞状态DOI: 10.1016/j.intimp.2026.116579
Circulation IF: 38.600Volume 153, Issue 13No.17Letter by Wu et al Regarding Article, "G Protein-Coupled Receptor Kinase 3 Exacerbates Diabetic Heart Injuries Through Direct Phosphorylation of Cannabinoid Receptor 2 in Humans and Mice"G蛋白偶联受体激酶3通过直接磷酸化人类和小鼠的大麻素受体2加重糖尿病心脏损伤DOI: 10.1161/CIRCULATIONAHA.125.077325
PeerJ IF: 02.400Volume 14, Issue No.18Impact of EV administration on murine hematology and metabolism小鼠中同源和异源细胞外囊泡给药对代谢和免疫反应的影响DOI: 10.7717/peerj.20952
J Hepatocell Carcinoma IF: 03.400Volume 13, Issue No.19"WBC-HBP Dissociation" Unveils Occult Xanthogranulomatous Inflammation Mimicking Hepatocellular Carcinoma in Diabetic Patients白细胞-肝素结合蛋白解离现象揭示糖尿病患者中类似肝细胞癌的隐匿性黄肉芽肿性炎症DOI: 10.2147/JHC.S596910
Front Cell Dev Biol IF: 04.300Volume 14, Issue No.20A metabolic-inflammatory burden phenotype associated with urinary glucose in colorectal cancer尿糖作为结直肠癌风险分层的代谢-炎症负担标志物DOI: 10.3389/fcell.2026.1797508
Clin Cosmet Investig Dent IF: 01.800Volume 18, Issue No.21Periodontitis Phenotypes and Treatment Outcomes Following Combined Periodontal and Orthodontic Therapy: A Cohort Study联合牙周和正畸治疗后牙周炎表型及治疗效果：一项队列研究DOI: 10.2147/CCIDE.S592473
Infection and drug resistance IF: 02.900Volume 19, Issue No.22Sepsis Caused by Clostridium Perfringens in an Elderly Female Patient with Breast Cancer: A Case Report恶性乳腺癌患者中的产气荚膜梭菌败血症：病例报告及文献综述DOI: 10.2147/IDR.S560686
Materials today bio IF: 10.200Volume 38, Issue No.23Procyanidin capsules attenuate PI3K/AKT-mediated mitochondrial dysfunction and accelerate skin wound healing in diabetic mice原花青素胶囊通过激活PI3K/AKT信号通路促进糖尿病皮肤伤口愈合DOI: 10.1016/j.mtbio.2026.103029
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.24Effectiveness and safety of Chinese traditional medicine Ulcer Ointment for skin ulcers: a systematic review and meta-analysis of randomized controlled trials溃疡软膏（UO）治疗皮肤溃疡的随机对照试验荟萃分析DOI: 10.3389/fphar.2026.1764562
Naunyn Schmiedebergs Arch Pharmacol IF: 03.100Ahead of Print.No.25Atractylenolide III improves ovarian dysfunction and endometrial receptivity in a PCOS rat model by regulating Cybb-mediated oxidative stress苍术酮III通过调节Cybb介导的氧化应激改善PCOS大鼠模型中的卵巢功能障碍和子宫内膜容受性DOI: 10.1007/s00210-026-05264-2
Acta pharmaceutica sinica B IF: 14.600Volume 16, Issue 3No.26Exploiting eNOS activation to achieve tumor vascular normalization via endothelial transcytosis of lipid nanoparticles利用脂质纳米颗粒经内皮细胞胞吞转运激活eNOS以实现肿瘤血管正常化DOI: 10.1016/j.apsb.2025.11.040
Acta pharmaceutica sinica B IF: 14.600Volume 16, Issue 3No.27Single-cell RNA sequencing-guided drug discovery to alleviate radiotherapy-induced esophageal toxicity单细胞RNA测序指导药物发现以减轻放疗诱导的食管毒性DOI: 10.1016/j.apsb.2025.12.038
Frontiers in reproductive health IF: 02.900Volume 7, Issue No.28The role and underlying mechanisms of Qi Gong Wan in enhancing the endometrial receptivity of a rat model with polycystic ovary syndrome七公丸（QGW）对多囊卵巢综合征诱导胰岛素抵抗（PCOS-IR）大鼠模型子宫内膜容受性的影响DOI: 10.3389/frph.2025.1733583
ACS Appl Mater Interfaces IF: 08.200Ahead of Print.No.29Injectable Dual-Cross-Linked Hydrogels Enabling Sequential Drug Release for Synergistic Periodontitis Therapy可注射双交联水凝胶实现顺序药物释放用于协同牙周炎治疗DOI: 10.1021/acsami.6c01751
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.30Impaired awareness of hypoglycemia: can structured education address this persistent challenge?低血糖感知障碍：结构化教育能否解决这一长期挑战？DOI: 10.3389/fendo.2026.1722045
iScience IF: 04.100Volume 29, Issue 4No.31An implantable dual-chamber capsule with three release modes for site-specific delivery and enhanced therapeutic efficacy具有三种释放模式的可植入双腔胶囊，用于定点给药并增强治疗有效性DOI: 10.1016/j.isci.2026.115099
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.32Molecular mechanisms and preclinical evidence of natural products in diabetic osteoporosis: a review天然产物作为糖尿病性骨质疏松症的多靶点调节剂：一篇叙事性综述DOI: 10.3389/fendo.2026.1793925
Frontiers in public health IF: 03.400Volume 14, Issue No.33Confronting the economic burden of diabetes: Can TCM DRG payment reform in China offer a viable solution? Insights from empirical research in Western ChinaDRG支付改革是否降低了中西医结合医院糖尿病患者的住院费用？来自中国西部一项间断时间序列分析的证据DOI: 10.3389/fpubh.2026.1792742
Int J Nanomedicine IF: 06.500Volume 21, Issue No.34Antimicrobial Hydrogel for Diabetic Wound Treatment用于糖尿病伤口治疗的抗菌水凝胶DOI: 10.2147/IJN.S572181
FCVM IF: 02.900Volume 13, Issue No.35Mitochondrial dysfunction in diabetic cardiomyopathy: a review of pathogenic mechanisms and therapeutic strategies糖尿病心肌病中的线粒体功能障碍：病理生理学、治疗策略及未来方向的综合综述DOI: 10.3389/fcvm.2026.1751243
Aging cell IF: 07.100Volume 25, Issue 4No.36Pck1 Deficiency Drives Mitochondrial Dysfunction and Cellular Senescence in AdipocytesPck1缺陷驱动脂肪细胞线粒体功能障碍和细胞衰老DOI: 10.1111/acel.70462
Gut microbes reportsVolume 2, Issue 1No.37Faecalibacterium longum alleviates high-fat diet-induced obesity and protects the intestinal epithelial barrier in mice长双歧杆菌缓解高脂饮食诱导的小鼠肥胖并保护肠上皮屏障DOI: 10.1080/29933935.2025.2459599
Bioactive materials IF: 20.300Volume 62, Issue No.38Nanomaterial-driven modulation of lipid metabolism: Novel strategies toward precision obesity treatment纳米材料驱动的脂质代谢调节：精准肥胖治疗的新策略DOI: 10.1016/j.bioactmat.2026.02.057
Clinical interventions in aging IF: 03.700Volume 21, Issue No.39Dynamic versus Static Metabolic Models for Predicting ECG-Defined Cardiovascular Risk in Elderly MAFLD: A Three-Year Cohort Study动态与静态代谢模型预测老年MAFLD患者心电图定义的心血管风险：一项为期三年的队列研究DOI: 10.2147/CIA.S567520
Frontiers in nutrition IF: 05.100Volume 13, Issue No.40Gut microbiota mediates the anti-obesity effects of Gnaphalium affine methanol extract in HFD-induced obesity香青兰提取物（GAE）通过调节肠道菌群和增强代谢功能减轻高脂饮食（HFD）诱导的肥胖DOI: 10.3389/fnut.2026.1779459
Frontiers in public health IF: 03.400Volume 14, Issue No.41Prevalence and influencing factors of functional constipation in Chinese children and adolescents: a systematic review and meta-analysis中国儿童青少年功能性便秘的患病率及影响因素：一项系统综述与荟萃分析DOI: 10.3389/fpubh.2026.1776863
Frontiers in medicine IF: 03.000Volume 13, Issue No.42Subchondral H-type blood vessel formation aggravates articular cartilage degeneration through LEP-LEPR axis瘦素/瘦素受体信号通路调控骨关节炎中软骨下骨H型血管生成和关节软骨降解DOI: 10.3389/fmed.2026.1751127
Frontiers in immunology IF: 05.900Volume 17, Issue No.43Unveiling the immune microenvironment in diabetic nephropathy: from mechanisms to therapeutics糖尿病肾病中的肾脏免疫微环境：机制、调控及治疗靶点DOI: 10.3389/fimmu.2026.1750484
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.44Assessing the association of FIB-4 index with diabetic kidney disease in patients with diabetes mellitus: a cross-sectional and retrospective study utilizing NHANES and clinical dataFib-4指数作为2型糖尿病患者糖尿病肾病进展的危险因素DOI: 10.3389/fendo.2026.1800874
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.45Unveiling the TrkA-p35/CDK5 axis: a novel therapeutic target in diabetic kidney diseaseTrkA抑制剂通过ERK/EGR1/p35/CDK5信号轴减轻糖尿病肾病中的足细胞损伤DOI: 10.3389/fendo.2026.1791283
iScience IF: 04.100Volume 29, Issue 4No.46Multidimensional analysis of depression and diabetic kidney disease using GBD, NHANES, and MR抑郁与糖尿病肾病：全球负担、观察性关联及遗传因果关系的多层级分析DOI: 10.1016/j.isci.2026.115265
Journal of inflammation research IF: 04.100Volume 19, Issue No.47SIRT2 in Diabetic Kidney Disease: Multifaceted Regulatory Roles and Therapeutic ChallengesSIRT2在糖尿病肾病中的作用机制、调控网络及治疗策略DOI: 10.2147/JIR.S588949
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.48Metabolic Crosstalk in Diabetic Kidney Disease: Synergistic Effects of Glucotoxicity and Lipotoxicity糖尿病肾病中的代谢串扰：糖毒性与脂毒性的协同作用DOI: 10.2147/DMSO.S580866
Digital health IF: 03.300Volume 12, Issue No.49Diabetic peripheral neuropathy identification using enface optical coherence tomography and multi-head attention deep learning algorithm使用多头部注意力深度学习的无创性糖尿病周围神经病变识别DOI: 10.1177/20552076261436274
Naunyn Schmiedebergs Arch Pharmacol IF: 03.100Ahead of Print.No.50Temsirolimus safety evaluation: real-world adverse event analysis from the FDA adverse event reporting system database西罗莫司安全评估：来自FDA不良事件报告系统数据库的真实世界不良事件分析DOI: 10.1007/s00210-026-05233-9
Acta pharmaceutica sinica B IF: 14.600Volume 16, Issue 3No.51Identification of a small-molecule targeting PLAGL2 DNA-binding domain inhibits extracellular matrix formation and enhances lenvatinib sensitivity in hepatocellular carcinoma靶向PLAGL2 DNA结合域的小分子抑制细胞外基质形成并增强肝细胞癌中仑法替尼敏感性DOI: 10.1016/j.apsb.2025.12.016
Frontiers in nutrition IF: 05.100Volume 13, Issue No.52One-month early time-restricted eating enhances cognition via white matter-cortical pathways in males with metabolic syndrome: evidence from TBSS and SBM analyses1个月早期限时饮食改善代谢综合征男性的代谢健康、认知功能及脑结构：基于丘脑-皮质通路视角DOI: 10.3389/fnut.2026.1753462
Frontiers in nutrition IF: 05.100Volume 13, Issue No.53Vitamin D and exercise in obesity: a neurovascular-muscle axis维生素D与运动在肥胖中的作用：神经血管-肌肉轴DOI: 10.3389/fnut.2026.1750915
Drug Des Devel Ther IF: 05.100Volume 20, Issue No.54Matrine in Liver Diseases: Mechanistic Insights and Therapeutic Potential苦参碱在肝脏疾病中的作用机制与治疗潜力DOI: 10.2147/DDDT.S577265
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.55Cardiovascular Outcomes and Safety of GLP-1 Receptor Agonists in Elderly Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis2型糖尿病老年患者中胰高血糖素样肽-1受体激动剂的心血管结局和安全性：一项系统综述和荟萃分析DOI: 10.2147/DMSO.S580095
Frontiers in immunology IF: 05.900Volume 17, Issue No.56Case report: Thymoma-associated GAD65 autoimmunity: a unifying mechanism for multi-organ injury involving nervous, endocrine, and renal systems胸腺瘤相关GAD65自身免疫：一种涉及神经、内分泌和肾脏系统多器官损伤的统一机制DOI: 10.3389/fimmu.2026.1790631
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.57Children with craniopharyngioma resection had better response to recombinant human growth hormone therapy than those with idiopathic short stature儿童颅咽管瘤患者的生长激素治疗：与特发性身材矮小的比较研究DOI: 10.3389/fendo.2026.1768846
Drug Des Devel Ther IF: 05.100Volume 20, Issue No.58A Comprehensive Review on the Cardioprotective and Nephroprotective Effects of Semaglutide, and Its Therapeutic Efficacy and Mechanisms in Cardiorenal Syndrome司美格鲁肽在心肾综合征中的应用：有效性、机制及临床证据综合综述DOI: 10.2147/DDDT.S581491
Drug Des Devel Ther IF: 05.100Volume 20, Issue No.59Potential Antiarrhythmic Mechanisms of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RAs)胰高血糖素样肽-1受体激动剂（GLP-1RAs）与心脏心律失常：作用机制与治疗潜力DOI: 10.2147/DDDT.S579419
Front Cell Dev Biol IF: 04.300Volume 14, Issue No.60Identification of mitochondria-related key genes in type 2 diabetes mellitus and elucidation of the Zhimu-Huangbai herb Pair's mechanism: an integrated approach of bioinformatics, machine learning, and experimental validation知母-黄柏对2型糖尿病的作用：通过线粒体功能多靶点调节的分子机制DOI: 10.3389/fcell.2026.1763178
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.61Plasma R-spondin 2 levels are associated with the progression of diabetic kidney disease血浆R-脊椎蛋白2水平与糖尿病肾病的进展相关DOI: 10.3389/fendo.2026.1787296
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.62Association Between Thyroid Hormone Sensitivity and Peripheral Arterial Disease in Euthyroid Patients with Type 2 Diabetes甲状腺功能正常的2型糖尿病患者中甲状腺激素敏感性与外周动脉疾病的关系DOI: 10.2147/DMSO.S571291
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.63Thyroid Hormone Indices and Histopathological Severity of Diabetic Nephropathy in Euthyroid Patients with Type 2 Diabetes: A Biopsy-Based Cross-Sectional Study甲状腺功能正常的2型糖尿病患者中甲状腺激素指标与糖尿病肾病组织病理学严重程度的关系：一项基于活检的横断面研究DOI: 10.2147/DMSO.S589576
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.64Correlation Between the Thyroid Hormone Levels and Type 2 Diabetes Mellitus in Non-Alcoholic Fatty Liver Disease非酒精性脂肪肝患者中甲状腺激素水平与2型糖尿病的关系：聚焦游离三碘甲状腺原氨酸与游离甲状腺素比值DOI: 10.2147/DMSO.S577491
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.65Emulating the LEADER trial in China: a regulatory science case study on non-interventional research在中国模拟LEADER试验：一项关于非干预性研究的监管科学案例研究DOI: 10.3389/fendo.2026.1777954
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.66Beyond the triglyceride-glucose index, the cholesterol- high-density lipoprotein -glucose index as a superior predictor for diabetes risk in patients with major adverse cardiovascular events: dual evidence from the CHARLS database and real-world data超越甘油三酯-葡萄糖指数，胆固醇-高密度脂蛋白-葡萄糖指数作为主要不良心血管事件患者糖尿病风险的更优预测指标：来自CHARLS数据库和真实世界数据的双重证据DOI: 10.3389/fendo.2026.1797342
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.67Analysis of the association between history of gestational diabetes mellitus and hypertensive disorders in a subsequent pregnancy: a retrospective cohort study妊娠期糖尿病（GDM）复发史与后续妊娠高血压疾病风险独立相关：一项大型回顾性队列研究DOI: 10.3389/fendo.2026.1736779
Frontiers in immunology IF: 05.900Volume 17, Issue No.68Timing of coffee consumption and insulin resistance: evidence from human and animal studies早晨咖啡摄入时间及其与胰岛素抵抗的关联：来自人类和动物实验的证据DOI: 10.3389/fimmu.2026.1775412
FCVM IF: 02.900Volume 13, Issue No.69From lipid dysbalance to cardiorenal decompensation: apoB/ApoA1 ratio is associated with acute cardiorenal injury in CAD patients载脂蛋白B/载脂蛋白A1比值与冠心病患者1型心肾综合征的关联DOI: 10.3389/fcvm.2026.1754713
Frontiers in oncology IF: 03.300Volume 16, Issue No.70The correlation between the triglyceride-glucose index and the odds of cervical cancer甘油三酯-葡萄糖指数与宫颈癌风险的关联研究DOI: 10.3389/fonc.2026.1766167
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.71Association between triglyceride glucose- systemic immune inflammation index and deep venous thrombosis in fresh fracture patient: a real-world retrospective study甘油三酯-葡萄糖系统性炎症指数(TyG-SII)与创伤性骨折患者术前深静脉血栓形成的单中心回顾性研究DOI: 10.3389/fendo.2026.1700809
Appl Biochem Biotechnol IF: 03.300Ahead of Print.No.72Metformin Induces Ferroptosis and Inhibits Malignant Progression in Diabetic Breast Cancer二甲双胍诱导铁死亡并抑制糖尿病乳腺癌的恶性进展DOI: 10.1007/s12010-026-05648-3
Appl Biochem Biotechnol IF: 03.300Ahead of Print.No.73BHMT Protects Against Diabetic Cataracts by Reducing Homocysteine and Counteracting Endoplasmic Reticulum Stress in Lens Epithelial CellsBHMT通过降低同型半胱氨酸并抵消晶状体上皮细胞中的内质网应激来预防糖尿病性白内障DOI: 10.1007/s12010-026-05678-x
Journal of Alzheimer's disease IF: 03.100Ahead of Print.No.74Polygenic and polysocial risk scores in post-type 2 diabetes dementia: Risk stratification and predictive modeling in the UK Biobank cohort多基因和多社会风险评分在2型糖尿病后痴呆中的应用：英国生物样本库队列中的风险分层与预测建模DOI: 10.1177/13872877261435200
Paediatr Perinat Epidemiol IF: 02.500Ahead of Print.No.75Haemoglobin Concentrations and Maternal and Neonatal Outcomes: Identifying Optimal Haemoglobin Ranges血红蛋白浓度与母婴结局：确定最佳血红蛋白范围DOI: 10.1111/ppe.70142
Acta pharmaceutica sinica B IF: 14.600Volume 16, Issue 3No.76Liver-pancreas communication in disease and drug development代谢性疾病中的肝脏-胰腺轴：从机制到治疗DOI: 10.1016/j.apsb.2026.01.018
Acta pharmaceutica sinica B IF: 14.600Volume 16, Issue 3No.77Integrating Chinese medicine and intermittent fasting: A promising approach for treating diabetic vascular calcification整合中医药与间歇性禁食：治疗糖尿病血管钙化的有前景方法DOI: 10.1016/j.apsb.2026.01.004
Frontiers in immunology IF: 05.900Volume 17, Issue No.78Transcending risk factors: the implications of redefining diabetes as an immunometabolic disease for infectious disease studies超越风险因素：将糖尿病重新定义为免疫代谢疾病对传染病研究的意义DOI: 10.3389/fimmu.2026.1794628
Bioactive materials IF: 20.300Volume 62, Issue No.79Intelligent-responsive hydrogel synergistically mediates immune remodel-antibacterial-angiogenesis cascade for diabetic foot ulcer repair智能响应水凝胶协同介导免疫重塑-抗菌-血管生成级联反应用于糖尿病足溃疡修复DOI: 10.1016/j.bioactmat.2026.03.034
Kidney diseases IF: 03.100Volume 12, Issue 1No.80Finerenone in Chinese Patients with Chronic Kidney Disease and Type 2 Diabetes: A FIDELITY Subgroup Analysis非奈利酮用于合并2型糖尿病的慢性肾脏病中国患者：FIDELITY亚组分析DOI: 10.1159/000550850
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Journal of diabetes IF: 03.700Volume 18, Issue 4No.83Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via Promoting Mitophagy富氢透明质酸敷料通过促进线粒体自噬改善糖尿病足溃疡DOI: 10.1111/1753-0407.70209
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J Natl Compr Canc Netw IF: 16.400Ahead of Print.No.19Clinically Sufficient Vitamin D Levels With Survival and Cardiovascular Outcomes in a Prospective Cohort of 3,995 Individuals Diagnosed With Invasive Breast Cancer临床充足的维生素D水平与3995例浸润性乳腺癌患者的生存及心血管结局的前瞻性队列研究DOI: 10.6004/jnccn.2025.7111
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J Natl Compr Canc Netw IF: 16.400Ahead of Print.No.34Results of the AiM, PLan, and act on LIFestYles (AMPLIFY) Weight Loss Intervention Among Survivors of Obesity-Related Cancers: A Randomized Clinical Trial肥胖相关癌症幸存者减重干预（AMPLIFY研究）的结果：一项随机临床试验DOI: 10.6004/jnccn.2026.7012
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Vitamins and hormonesVolume 131, Issue No.54Acromegaly-Physiopathology and etiology肢端肥大症-病理生理学和病因学DOI: 10.1016/bs.vh.2026.01.001
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Proc Natl Acad Sci U S A IF: 09.100Volume 123, Issue 14No.65Fatty acid regulation of feeding in Caenorhabditis elegans reveals the potential ancestral origin of a GLP-1-like multiagonist signaling system秀丽隐杆线虫中脂肪酸对摄食的调节揭示了类似GLP-1的多激动剂信号系统的潜在祖先起源DOI: 10.1073/pnas.2530979123
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PloS one IF: 02.600Volume 21, Issue 3No.70Testing the feasibility of blood flow restriction training to enhance the HEALTH benefits of exercise in individuals with type 2 diabetes (BOOST-HEALTH Trial): Study Protocol测试血流限制训练在增强2型糖尿病患者运动健康益处方面的可行性（BOOST-HEALTH试验）：研究方案DOI: 10.1371/journal.pone.0346176
PloS one IF: 02.600Volume 21, Issue 3No.71Psychosocial predictors of non-adherence to antihypertensive medication among Korean adults: A nationwide cross-sectional study韩国成年人降压药物不依从的心理社会预测因素：一项全国性横断面研究DOI: 10.1371/journal.pone.0345509
Diabetes care IF: 16.600Ahead of Print.No.72Screening for Diabetes and Prediabetes in Cystic Fibrosis Using a Nonfasting 50-Gram 1-Hour Oral Glucose Challenge Test囊性纤维化中使用非空腹50克1小时口服葡萄糖耐量试验筛查糖尿病和前驱糖尿病DOI: 10.2337/dc25-2806
PloS one IF: 02.600Volume 21, Issue 3No.73Temporal-spatial trends in childbirth in Ontario, Canada加拿大安大略省分娩的时空趋势DOI: 10.1371/journal.pone.0342215
PloS one IF: 02.600Volume 21, Issue 3No.74Editorial Note: Machine learning-driven Diabetes Health Tracer (DHT): Optimizing prognosis using RaSK_GraDe and RaSK_GraDeL models社论注记：机器学习驱动的糖尿病健康追踪器（DHT）：使用RaSK_GraDe和RaSK_GraDeL模型优化预后DOI: 10.1371/journal.pone.0346001
PloS one IF: 02.600Volume 21, Issue 3No.75The effect of game-based education on adherence to treatment and anxiety level in type 2 diabetics started on insulin therapy游戏化教育对开始胰岛素治疗的2型糖尿病患者的治疗依从性和焦虑水平的影响DOI: 10.1371/journal.pone.0345292
Hormone research in p?diatrics : IF: 02.700Ahead of Print.No.76T1D GRS: a tool for identifying children and adolescents with monogenic diabetesT1D GRS：一种用于识别儿童和青少年单基因糖尿病的工具DOI: 10.1159/000551615
Age and ageing IF: 07.100Volume 55, Issue 3No.77Effectiveness of non-pharmacological and pharmacological interventions in preventing delirium in older adults: a systematic review and meta-analysis of randomised controlled trials非药物和药物干预措施在预防老年人谵妄中的有效性：一项随机对照试验的系统综述和荟萃分析DOI: 10.1093/ageing/afag068
Frontiers in physiology IF: 03.400Volume 17, Issue No.78MsrB2 deficiency amplifies ECM-driven cardiac fibrosis under hypertensive stress甲硫氨酸亚砜还原酶B2（MsrB2）缺陷在高血压应激下放大细胞外基质驱动的心脏纤维化DOI: 10.3389/fphys.2026.1772933
Gut microbes reportsVolume 3, Issue 1No.79Obesity-associated gut microbiome influences diet-induced metabolic and cognitive outcomes in older adults肥胖与肠道菌群作为老年人群认知衰退的关键驱动因素：系统综述与荟萃分析DOI: 10.1080/29933935.2025.2605879
iScience IF: 04.100Volume 29, Issue 4No.80Accumulated mtDNA mutations are linked to specific impairments in NADH-linked respiration累积的mtDNA突变与NADH相关呼吸的特定损伤相关联DOI: 10.1016/j.isci.2026.115184
iScience IF: 04.100Volume 29, Issue 4No.81A Novel mechanism for depot-specific leptin gene expression regulation and its persistence after weight loss脂肪库特异性瘦素基因表达调控的新机制及其减重后的持续性DOI: 10.1016/j.isci.2026.115101
Frontiers in medicine IF: 03.000Volume 13, Issue No.82Limited transferability of European-based body mass index and blood pressure polygenic scores to admixed Brazilian cohorts英国生物样本库衍生多基因风险评分在巴西队列中的有限可转移性DOI: 10.3389/fmed.2026.1771205
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.83Six-year Follow-Up of Nonpharmacological and Nonsurgical Obesity Treatments非药物和非手术肥胖治疗的六年随访DOI: 10.2147/DMSO.S590255
JCEM case reportsVolume 4, Issue 4No.84Unanticipated remission of primary hyperparathyroidism following cinacalcet西那卡塞治疗后原发性甲状旁腺功能亢进症的意外缓解DOI: 10.1210/jcemcr/luag014
Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.85Continuous glucose monitoring, diabetes distress, and well-being in adults with type 1 diabetes: findings from a National Survey in Lithuania连续性葡萄糖监测、1型糖尿病患者的糖尿病困扰及幸福感：来自立陶宛全国性调查的结果DOI: 10.3389/fcdhc.2026.1708124
Preventive medicine reports IF: 02.400Volume 65, Issue No.86Sex differences in the prospective associations of long COVID with incident cardiometabolic and respiratory diseases from a population-based longitudinal study in Michigan密歇根州基于人群的纵向研究中，长期新冠与新发心血管代谢及呼吸系统疾病关联的性别差异DOI: 10.1016/j.pmedr.2026.103449
J Clin Exp Hepatol IF: 03.200Volume 16, Issue 3No.87The Association Between Genetic Polymorphism in the Receptor for Advanced Glycation End-Products and Metabolic Dysfunction-Associated Steatotic Liver Disease晚期糖基化终产物受体基因多态性与代谢功能障碍相关脂肪性肝病的关联DOI: 10.1016/j.jceh.2026.103530
Kidney medicine IF: 03.400Volume 8, Issue 4No.88Primary Care Use and Clinical Outcomes in a Prevalent Cohort of Patients Receiving Hemodialysis接受中心性血液透析的医疗保险受益人中初级医疗服务使用情况及临床结局DOI: 10.1016/j.xkme.2026.101278
In silico pharmacologyVolume 14, Issue 1No.89NMR-guided metabolomic evaluation of Aegle marmelos (L.) Correa: unveiling antihypertensive, antidiabetic, and anti-inflammatory activitiesNMR引导的木苹果代谢组学评估：揭示其抗高血压、抗糖尿病及抗炎活性DOI: 10.1007/s40203-026-00609-4
Bioinformation IF: 01.900Volume 21, Issue 12No.90Maternal obesity and its impact on pregnancy孕妇肥胖及其对妊娠的影响DOI: 10.6026/973206300214648
Bioinformation IF: 01.900Volume 21, Issue 12No.91Oral lesions in patients with systemic diseases: A hospital-based observational study系统性疾病患者的口腔病变：一项基于医院的观察性研究DOI: 10.6026/973206300214359
J Taibah Univ Med Sci IF: 01.900Volume 21, Issue 2No.92Evaluation of the circular RNA Pum1_0014, miRNA-146a, and miRNA-141-3p as biomarkers in PCOSPum1_0014环状RNA、miRNA-146a和miRNA-141-3p作为多囊卵巢综合征生物标志物的评估DOI: 10.1016/j.jtumed.2026.03.002
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.93Metabolic-associated steatotic liver disease in children and adolescents: a scoping review and narrative synthesis of epidemiology, risk factors, and screening approaches with emerging implications for sub-Saharan Africa撒哈拉以南非洲地区儿童代谢相关脂肪性肝病：范围综述DOI: 10.3389/fendo.2026.1784970
Int J Nanomedicine IF: 06.500Volume 21, Issue No.94Chitosan-Microcapsulated Insulin Alleviates Mesenteric Microcirculation Dysfunction via Modulating COX-2 and VCAM-1 Expression in Rats with Diabetes Mellitus [Retraction]壳聚糖微囊化胰岛素通过调节糖尿病大鼠COX-2和VCAM-1表达改善肠系膜微循环功能障碍 [撤稿]DOI: 10.2147/IJN.S599834
Acta Cardiologica Sinica IF: 01.800Volume 42, Issue 2No.95Nirmatrelvir/Ritonavir-Induced Calcium Channel Blocker Intoxication Successfully Treated by High Dose Insulin Therapy奈玛特韦/利托那韦诱导的钙通道阻滞剂中毒经大剂量胰岛素治疗成功DOI: 10.6515/ACS.202603_42(2).20251213B
Br J Community NursVolume 31, Issue 4No.96Management of diabetes when comorbid with dementia痴呆合并糖尿病的管理DOI: 10.12968/bjcn.2026.0042
Curēus IF: 01.300Volume 18, Issue 2No.97Differentiated and Poorly Differentiated Thyroid Carcinoma in Ovarian Teratoma With Primary Papillary Thyroid Carcinoma: A Series of Two Case Reports卵巢畸胎瘤中合并原发性乳头状甲状腺癌的分化型和未分化型甲状腺癌：两例病例报告DOI: 10.7759/cureus.104169
Curēus IF: 01.300Volume 18, Issue 2No.98Exercise Intervention for Blood Pressure Reduction in Diabetic Patients: A Systematic Review and Meta-Analysis糖尿病患者的血压降低运动干预：一项系统综述和荟萃分析DOI: 10.7759/cureus.104244
Curēus IF: 01.300Volume 18, Issue 2No.99Clinico-Microbiological Profile of Carbapenem-Resistant Acinetobacter baumannii Isolates From Intensive Care Unit Patients and In Vitro Activity of Sulbactam-Durlobactam: A Cross-Sectional Study From Eastern India印度东部三级医院重症监护病房中碳青霉烯耐药鲍曼不动杆菌的临床及抗菌药物敏感性分析DOI: 10.7759/cureus.104172
Curēus IF: 01.300Volume 18, Issue 2No.100Intramedullary Spinal Cord Abscess With Brain Abscess Secondary to Empyema: A Report of a Rare Case继发于脓胸的髓内脊髓脓肿合并脑脓肿：一例罕见病例报告DOI: 10.7759/cureus.104151
Curēus IF: 01.300Volume 18, Issue 2No.101Assessing Mortality Prediction: Comparing the Effectiveness of the Fournier Gangrene Severity Index and the Uludag Index评估死亡率预测：比较Fournier坏疽严重度指数与Uludag指数的有效性DOI: 10.7759/cureus.104290
Curēus IF: 01.300Volume 18, Issue 2No.102Emphysematous Gastritis With Portal and Mesenteric Venous Gas Complicated by Septic Shock and Ileus: A Case Report伴有门静脉和肠系膜静脉气体的气肿性胃炎，表现为严重休克和肠梗阻：一例报告及文献综述DOI: 10.7759/cureus.104164
Frontiers in nutrition IF: 05.100Volume 13, Issue No.103Barriers and facilitators for consuming a plant-based diet in patients with knee osteoarthritis: a qualitative study膝关节骨关节炎患者食用植物性饮食的障碍与促进因素：一项定性研究DOI: 10.3389/fnut.2026.1743219
J Public Health ResVolume 15, Issue 1No.104In-hospital mortality and its predictors among adult ischemic stroke patients in public hospitals in the Harari region, Eastern Ethiopia: A retrospective cohort study埃塞俄比亚东部哈拉里市公立医院成人缺血性卒中患者的死亡率及其预测因素：一项回顾性队列研究DOI: 10.1177/22799036261433150
Kidney medicine IF: 03.400Volume 8, Issue 4No.105Outcomes and Risk Factors of Widened Difference in Estimated Glomerular Filtration Rate Based on Creatinine or Cystatin C: Adjust Model Development With More Than 300,000 UK Biobank Participants慢性肾脏病流行病学协作组（CKD-EPI）基于肌酐、胱抑素C及两者结合估算肾小球滤过率（eGFR）：英国生物样本库中的差异分析与预测价值DOI: 10.1016/j.xkme.2026.101288
Infection and drug resistance IF: 02.900Volume 19, Issue No.106Management of Diabetic Foot Infections Using Phage Therapy噬菌体疗法在糖尿病足感染中的综合综述DOI: 10.2147/IDR.S577526
Curēus IF: 01.300Volume 18, Issue 2No.107Unprovoked Deep Vein Thrombosis as a Manifestation of Cushing's Disease自发性深静脉血栓形成作为库欣病的一种表现DOI: 10.7759/cureus.104148
Farmaceuticos comunitarios IF: 00.500Volume 18, Issue 2No.108Mystery Shopper: Antibiotics for sale at flea markets in a Mexican urban area神秘购物者：墨西哥城市地区跳蚤市场中抗生素的销售情况DOI: 10.33620/FC.2173-9218.2026.16
Bioinformation IF: 01.900Volume 21, Issue 12No.109Gender differences in outcomes among patients with heart failure and preserved ejection fraction: A retrospective cohort study射血分数保留的心力衰竭患者结局中的性别差异：一项回顾性队列研究DOI: 10.6026/973206300214355
Safety and health at work IF: 02.900Volume 17, Issue 1No.110Do the Long-Term Cardiometabolic Effects of Night Shift Work Differ Between Men and Women? A 17-Year Cohort Study of the U.S. Workforce夜班工作对男女心代谢健康的长期影响是否存在差异？一项针对美国劳动力的17年队列研究DOI: 10.1016/j.shaw.2025.11.001
FCVM IF: 02.900Volume 13, Issue No.111Impact of a combined care ambulatory and home-based aerobic exercise program using wearables on anxiety and depression in patients with metabolic syndrome结合门诊和家庭有氧运动项目及远程可穿戴设备监测改善代谢综合征患者的焦虑和抑郁症状DOI: 10.3389/fcvm.2026.1798233
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.112Selective phosphoinositide 3-kinase inhibitors and implication in diabetic retinopathy as pharmacological tools磷酸肌醇3-激酶异构体选择性及定量构效关系（QSAR）在糖尿病视网膜病变药物设计中的研究DOI: 10.3389/fphar.2026.1744181
Int Med Case Rep J IF: 00.600Volume 19, Issue No.113Bilateral Superior Branch Retinal Artery Occlusions in a Patient on Pembrolizumab使用帕博利珠单抗治疗的患者出现双眼分支视网膜动脉闭塞DOI: 10.2147/IMCRJ.S584574
Frontiers in medicine IF: 03.000Volume 13, Issue No.114Diabetic retinopathy severity detection using an improved Whale optimization algorithm and convolutional Kolmogorov-Arnold network使用改进鲸鱼优化算法和卷积Kolmogorov-Arnold网络的糖尿病视网膜病变严重程度检测DOI: 10.3389/fmed.2026.1709872
Preventive medicine reports IF: 02.400Volume 65, Issue No.115Nationwide trends and geographic variations of diabetes in pregnancy in Thailand: Epidemiology, neonatal outcomes, and healthcare costs under the universal health coverage scheme (2013-2023)泰国妊娠期糖尿病全国趋势与地理变异：全民医保计划下的流行病学、新生儿结局及医疗费用（2013-2023）DOI: 10.1016/j.pmedr.2026.103452
J Diabetes Metab Disord IF: 01.600Volume 25, Issue 1No.116The transformative role of artificial intelligence in gestational diabetes mellitus: advancements in screening, management, and long-term outcome prediction人工智能在妊娠糖尿病管理中的变革性作用：筛查、管理及长期预后预测的进展DOI: 10.1007/s40200-025-01817-z
Bioinformation IF: 01.900Volume 21, Issue 12No.117Prevalence of gestational diabetes using IADPSG criteria in North India: A cross-sectional study北印度地区应用IADPSG标准的妊娠糖尿病患病率：一项横断面研究DOI: 10.6026/973206300214876
Bioinformation IF: 01.900Volume 21, Issue 12No.118Impact of thyroid autoantibodies on pregnancy: A prospective cohort study甲状腺自身抗体对妊娠的影响：一项前瞻性队列研究DOI: 10.6026/973206300214749
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.119Machine Learning-Derived Predictive Risk Score for Prediabetes and Type 2 Diabetes Development in Parous WomenG4PD指数：机器学习推导的经产妇女糖尿病前期和2型糖尿病风险评分DOI: 10.2147/DMSO.S590000
Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.120Prediabetes in acute coronary syndrome: an overlooked predictor of adverse outcomes糖尿病前期在急性冠脉综合征中的作用：被忽视的不良结局预测因子DOI: 10.3389/fcdhc.2026.1745724
Glob Cardiol Sci PractVolume 2025, Issue 2No.121Evaluation of electrocardiographic alterations before and after bariatric surgery重度肥胖患者减重手术前后的心电图变化DOI: 10.21542/gcsp.2025.22
J Cardiovasc Surg (Torino) IF: 01.500Ahead of Print.No.122Operative time and outcome after carotid endarterectomy for symptomatic and asymptomatic carotid stenosis: a retrospective multicenter cohort study有症状和无症状颈动脉狭窄患者颈动脉内膜切除术的手术时间与结局：一项回顾性多中心队列研究DOI: 10.23736/S0021-9509.26.13541-1
East Mediterr Health J IF: 01.900Volume 32, Issue 3No.123Association between vitamin D deficiency and metabolic syndrome among adults in Arab countries阿拉伯国家成年人维生素D缺乏与代谢综合征的关联DOI: 10.26719/2026.32.3.156
Gut microbes reportsVolume 2, Issue 1No.124Gut microbial metabolites as a convergence point between autoimmunity and solid tumors肠道微生物群在连接自身免疫性疾病与癌症中的作用DOI: 10.1080/29933935.2025.2470805
Curēus IF: 01.300Volume 18, Issue 2No.125Association of Gastrointestinal Symptoms and Psychological Issues With the Intake of Fruits, Vegetables, and Junk Food in School Children: A Community-Based Study From Melmaruvathur, Tamil Nadu, India印度泰米尔纳德邦学童中显著的胃肠道症状、心理问题及异常营养状况：一项基于社区的研究DOI: 10.7759/cureus.104262
Curēus IF: 01.300Volume 18, Issue 2No.126Racial and Gender Disparities in the Occurrence and Outcomes of Alcohol-Associated Hepatitis in Hospitalized Patients With Prior Bariatric Surgery减重手术后酒精性肝炎的结局：基于全国住院患者样本的分析DOI: 10.7759/cureus.104251
Curēus IF: 01.300Volume 18, Issue 2No.127Skin-Only Closure Versus Bogota Bag: A Comparative Study of Complete Fascial Approximation Rates皮肤仅闭合术与波哥大袋闭合术：完整筋膜近似率的对比研究DOI: 10.7759/cureus.104203
Curēus IF: 01.300Volume 18, Issue 2No.128Spectrum and Management of Anorectal Disorders: A Retrospective Analysis From the United Arab Emirates阿联酋肛门直肠疾病回顾性分析：人口统计学特征、临床表现与管理策略DOI: 10.7759/cureus.104155
JCEM case reportsVolume 4, Issue 4No.129Phenotypic heterogeneity and polygenic risk scores in a family of maturity-onset diabetes of the young青年成熟期糖尿病家族的表型异质性与多基因风险评分DOI: 10.1210/jcemcr/luag001
Indian journal of orthopaedics IF: 01.100Volume 60, Issue 3No.130Obesity and Knee Arthroplasty: One Size Does Not Fit All-A Review with an Indian Perspective肥胖与膝关节置换术：一刀切并不适用——从印度视角的综述DOI: 10.1007/s43465-025-01669-y
Indian journal of orthopaedics IF: 01.100Volume 60, Issue 3No.131Functional Outcome of Single Bundle ACL Reconstruction with Superficial Quadriceps Tendon Graft in an Indian Cohort: A 3-Year Study印度队列中浅层股四头肌肌腱单束前交叉韧带重建的功能结果：一项为期3年的研究DOI: 10.1007/s43465-026-01750-0
Indian journal of orthopaedics IF: 01.100Volume 60, Issue 3No.132Impact of Glucagon-Like Peptide-1 Receptor Agonists on Knee Arthroplasty Outcomes胰高血糖素样肽-1受体激动剂与全膝关节置换术结局：一项系统综述和荟萃分析DOI: 10.1007/s43465-025-01646-5
Frontiers in public health IF: 03.400Volume 14, Issue No.133From gene to plate in Indonesia: a food system framework for the triple burden of malnutrition遗传创新、生物多样性与气候智能型农业：秘鲁、印度尼西亚和南非应对三重营养不良负担的系统性方法DOI: 10.3389/fpubh.2026.1755411
Curēus IF: 01.300Volume 18, Issue 3No.134Defining, Evaluating, and Managing Postoperative Respiratory Depression: An e-Delphi Study术后呼吸抑制（PORD）的共识定义与临床框架：一项电子德尔菲研究DOI: 10.7759/cureus.104612
J Taibah Univ Med Sci IF: 01.900Volume 21, Issue 2No.135Effectiveness of a school-based obesity control program among adolescents in Makkah: A pretest-posttest intervention study麦加青少年基于学校的肥胖控制项目的有效性：一项前测-后测干预研究DOI: 10.1016/j.jtumed.2026.03.005
J Taibah Univ Med Sci IF: 01.900Volume 21, Issue 2No.136Variations in serum ferritin levels in women with polycystic ovarian syndrome undergoing assisted reproduction接受辅助生殖治疗的多囊卵巢综合征女性血清铁蛋白水平的变化DOI: 10.1016/j.jtumed.2026.03.004
Bioinformation IF: 01.900Volume 21, Issue 12No.137Assessment of health management strategies and socioeconomic factors contributing to obesity in urban populations城市人群中健康管理策略及社会经济因素对肥胖的影响评估DOI: 10.6026/973206300215038
ArXivVolume 2026, Issue No.138Modeling Metabolic State Transitions in Obesity Using a Time-Varying Lambda-Omega Framework使用时变λ-Ω框架模拟肥胖中的代谢状态转变https://pubmed.ncbi.nlm.nih.gov/41907585
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.139The melanocortin receptors as targets for general obesity: contextualizing clinical failures and analyzing future perspectives促黑素激动剂：从临床前失败到肥胖治疗的新兴疗法DOI: 10.3389/fendo.2026.1797586
Frontiers in physiology IF: 03.400Volume 17, Issue No.140Effects of psychophysiological stress on perceptual responses during low-volume high intensity interval exercise: insights from ACTH and cortisol in overweight-to-obese adults低容量高强度间歇运动改善超重和肥胖成人的心理生理应激及感知反应DOI: 10.3389/fphys.2026.1762153
Plast Reconstr Surg Glob Open IF: 01.800Volume 14, Issue 3No.141Management of Severe Buried Penis With Bilateral Hernia重度埋藏阴茎合并双侧疝的管理DOI: 10.1097/GOX.0000000000007601
FCVM IF: 02.900Volume 13, Issue No.142The impact of body composition variability on coagulation monitoring in patients on direct oral factor Xa inhibitors for treatment of venous thromboembolism生物信息指导的抗Xa治疗（BIARIVA）中的体成分与凝血监测：一项初步研究DOI: 10.3389/fcvm.2026.1773664
Acta Cardiologica Sinica IF: 01.800Volume 42, Issue 2No.143Goal Attainment Rate in Secondary Prevention in Taiwan - A Chang Gung Research Database Study台湾动脉粥样硬化性心血管疾病患者二级预防中低密度脂蛋白胆固醇目标达标率研究——基于长庚研究数据库DOI: 10.6515/ACS.202603_42(2).20251012A
Expert Rev Clin Pharmacol IF: 03.000Ahead of Print.No.144Pharmacokinetics, efficacy, and safety of arsenic formulations in acute promyelocytic leukemia treatment急性早幼粒细胞白血病治疗中砷制剂的药代动力学、有效性和安全性DOI: 10.1080/17512433.2026.2652979
Kidney medicine IF: 03.400Volume 8, Issue 4No.145SGLT2 Inhibitors, Muscle Loss, and Creatinine-Based Estimated GFR: An Integrative Conceptual Review of Renoprotection基于肌酐的eGFR终点评估中肌肉质量流失对SGLT2抑制剂肾脏保护作用的影响DOI: 10.1016/j.xkme.2026.101297
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.146Safety and efficacy of tirzepatide in transplant recipients: a systematic review and meta-analysis替尔泊肽在实体器官移植受者中的安全性和有效性：一项系统综述和荟萃分析DOI: 10.3389/fphar.2026.1735987
Pediatrics international IF: 00.900Volume 68, Issue 1No.147A nonsurgical cecal slurry model for neonatal sepsis: Pathophysiological insights and therapeutic applications用于新生儿败血症的非手术盲肠浆模型：病理生理学见解与治疗应用DOI: 10.1111/ped.70381
Frontiers in reproductive health IF: 02.900Volume 8, Issue No.148Correction: The role and underlying mechanisms of Qi Gong Wan in enhancing the endometrial receptivity of a rat model with polycystic ovary syndrome修正：芪功丸在增强多囊卵巢综合征大鼠模型子宫内膜容受性中的作用及潜在机制DOI: 10.3389/frph.2026.1826232
Curēus IF: 01.300Volume 18, Issue 2No.149Exploring the Immunological Shield Hypothesis: A Population-Based Exploration of Phenotypic Divergence Between Lipedema and Celiac Disease Autoimmunity脂肪性水肿与乳糜泻：全国代表性大样本中的不同表型DOI: 10.7759/cureus.104222
Curēus IF: 01.300Volume 18, Issue 2No.150Necrobiosis Lipoidica in Pregnancy Complicated by Gestational Diabetes Mellitus: A Case Report妊娠期糖尿病合并坏死性类脂质硬化症病例报告DOI: 10.7759/cureus.104273
Curēus IF: 01.300Volume 18, Issue 2No.151Insulin Glulisine Versus Regular Human Insulin for Prednisolone-Associated Hyperglycemia Assessed by Continuous Glucose Monitoring: An Open-Label Crossover Study连续葡萄糖监测评估的赖脯胰岛素与常规人胰岛素治疗泼尼松龙相关高血糖的开放标签交叉研究DOI: 10.7759/cureus.104228
Am J Lifestyle Med IF: 01.300Ahead of Print.No.152Medication Deprescribing Practices Among Lifestyle Medicine Providers: A Cross-Sectional Survey生活方式医学临床医生在启动生活方式医学糖尿病管理后调整降糖药物的调查DOI: 10.1177/15598276261430281
Discover analyticsVolume 4, Issue 1No.153Flexible statistical approaches for modeling nonlinear relationships in diabetes prediction using splines, Bayesian kernel regression and Bayesian regression trees使用皮马印第安人数据库进行糖尿病预测的非线性统计方法比较分析DOI: 10.1007/s44257-026-00057-6
Genom PsychiatryVolume 1, Issue 4No.154Varying levels of interleukin 1 receptor antagonist (Il1rn) gene expression affect circulating leptin concentrations and fat distribution白细胞介素1受体拮抗剂（Il1rn）基因表达水平的变化影响循环瘦素浓度和脂肪分布DOI: 10.61373/gp025l.0056
Toxicon X IF: 02.800Volume 30, Issue No.155Biochemical characterisation and substrate-specific proteolytic diversity of venom metalloproteinases in African puff adders非洲黑眉蝮蛇（Bitis arietans）毒液金属蛋白酶的生化与免疫学特征DOI: 10.1016/j.toxcx.2026.100253
Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.156Cumulative burden of diabetes-related complications and health-related quality of life in primary care: a cross-sectional study from Mexico墨西哥基层医疗中2型糖尿病相关并发症累积负担及健康相关生活质量研究：一项横断面研究DOI: 10.3389/fcdhc.2026.1773692
3 biotech IF: 02.900Volume 16, Issue 4No.157α-Glucosidase inhibitor: identifying key targets and mechanisms in type 2 diabetesα-葡萄糖苷酶抑制剂：识别2型糖尿病的关键靶点和机制DOI: 10.1007/s13205-026-04772-5
Frontiers in medicine IF: 03.000Volume 13, Issue No.158Skin lesions in patients treated with growth hormone and those with growth hormone excess: a current overview接受生长激素治疗患者及生长激素过多患者的皮肤表现：当前综述DOI: 10.3389/fmed.2026.1777658
Neurochemical research IF: 03.800Volume 51, Issue 2No.159Vitamin D(3) Attenuates Alzheimer's Disease-Like Pathology via Remodeling Amyloid Protein Production and Clearance Pathway in Wistar Rats维生素D₃通过重塑淀粉样蛋白产生与清除途径减轻Wistar大鼠的阿尔茨海默病样病理DOI: 10.1007/s11064-026-04721-x
Tremor Other Hyperkinet Mov (N Y) IF: 02.100Volume 16, Issue No.160Paroxysmal Hemidystonia as the Presenting Manifestation of Previously Undiagnosed Diabetes Mellitus发作性偏身肌张力障碍作为既往未诊断糖尿病的首发表现DOI: 10.5334/tohm.1185
Curēus IF: 01.300Volume 18, Issue 2No.161Weight Regain After GLP-1-Based Therapy Discontinuation: Failure, Physiology, or Follow-Up GapGLP-1受体激动剂疗法停药后的体重反弹：失败、生理机制还是随访缺口DOI: 10.7759/cureus.104259
Int J Nephrol Renovasc Dis IF: 02.500Volume 19, Issue No.162Current Insights and Future Directions on the Role of GLP-1 Receptor Agonists in Chronic Kidney DiseaseGLP-1受体激动剂在慢性肾脏病中的应用现状与未来方向DOI: 10.2147/IJNRD.S522424
Plast Reconstr Surg Glob Open IF: 01.800Volume 14, Issue 3No.163The Glucagon-like Peptide-1 Receptor Agonist Era and Its Influence on Body-Contouring Referrals After Weight Loss in Appalachia胰高血糖素样肽-1受体激动剂时代及其对阿巴拉契亚地区减重后体型塑造转诊的影响DOI: 10.1097/GOX.0000000000007620
Int J Gen Med IF: 02.000Volume 19, Issue No.164Association Between Genotype and Plasma Levels of EPCR in Type 2 Diabetes Mellitus in Jazan Region, Saudi Arabia: A Case-Control Study内皮蛋白C受体（EPCR）多态性rs867186与2型糖尿病患者血浆可溶性EPCR水平及血液学参数的关联DOI: 10.2147/IJGM.S566052
Curēus IF: 01.300Volume 18, Issue 2No.165Fulminant Toxic Megacolon Without Identifiable Underlying Cause Requiring Emergent Total Colectomy: A Case Report暴发性中毒性巨结肠无明确根本病因需紧急全结肠切除一例报告DOI: 10.7759/cureus.104288
Curēus IF: 01.300Volume 18, Issue 2No.166A Rare Case of Tirzepatide-Associated Immune Thrombocytopenia替尔泊肽相关免疫性血小板减少症的罕见病例DOI: 10.7759/cureus.104281
Curēus IF: 01.300Volume 18, Issue 2No.167Drug Prescribing Patterns in Geriatric Patients With Type 2 Diabetes Mellitus at a Tertiary Care Teaching Hospital: A Cross-Sectional Study老年2型糖尿病患者在三级医院的处方模式：一项真实世界观察性研究DOI: 10.7759/cureus.104264
Curēus IF: 01.300Volume 18, Issue 2No.168X-ray Findings in a Case of Acute Osteomyelitis Following Puncture Injury: A Case Report穿刺伤后急性骨髓炎一例的X线表现：病例报告DOI: 10.7759/cureus.104291
Curēus IF: 01.300Volume 18, Issue 2No.169Where Is the Lactate Coming From? An Unusual Presentation of Persistent Lactic Acidosis乳酸从何而来？持续性乳酸酸中毒的罕见表现DOI: 10.7759/cureus.104328
Curēus IF: 01.300Volume 18, Issue 2No.170Understanding Diabetes Distress: A Study of Contributing Factors Among Adults With Type 2 Diabetes in Rural East Godavari, Andhra Pradesh印度安得拉邦农村地区2型糖尿病成年患者糖尿病困扰的患病率及相关因素DOI: 10.7759/cureus.104183
Curēus IF: 01.300Volume 18, Issue 2No.171Determinants of Left Ventricular Diastolic Dysfunction in Normotensive Patients With Type 2 Diabetes Mellitus: A Tertiary Hospital-Based Study in Ghana正常血压2型糖尿病患者左心室舒张功能障碍的决定因素：基于加纳一家三级医院的研究DOI: 10.7759/cureus.104317
J Public Health ResVolume 15, Issue 1No.172Traditional diets and cultural beliefs affecting diabetes prevention and control in Africa撒哈拉以南非洲2型糖尿病预防与控制：传统非洲饮食和以社区为中心的方法综合综述DOI: 10.1177/22799036261430965
Bioinformation IF: 01.900Volume 21, Issue 12No.173Management of type 2 diabetes mellitus using Yoga: Implications for immunological and autonomic dysfunction使用瑜伽管理2型糖尿病：对免疫和自主神经功能障碍的影响DOI: 10.6026/973206300214777
Bioinformation IF: 01.900Volume 21, Issue 12No.174Salivary and serum alkaline phosphatase as biomarkers in type 2 diabetes mellitus: Association with periodontal health and disease唾液和血清碱性磷酸酶作为2型糖尿病的生物标志物：与牙周健康和疾病的关联DOI: 10.6026/973206300214559
Bioinformation IF: 01.900Volume 21, Issue 12No.175Evaluation of antioxidant enzyme activity among Indian patients with type 2 diabetes mellitus印度2型糖尿病患者抗氧化酶活性的评估DOI: 10.6026/973206300215029
Bioinformation IF: 01.900Volume 21, Issue 12No.176Integrative management of chronic kidney disease: A case study combining siddha and modern medicine慢性肾脏病的综合管理：结合悉达（传统）医学与现代医学的案例研究DOI: 10.6026/973206300214344
Clinical ophthalmology IF: 02.200Volume 20, Issue No.177Glucagon-Like Peptide-1 Analogs Associated with a Reduced Risk of Legal Blindness in Type 2 Diabetics with Cardiovascular Risks胰高血糖素样肽-1受体激动剂降低2型糖尿病合并心血管风险因素患者的法律失明风险DOI: 10.2147/OPTH.S581826
Front Mol Biosci IF: 04.000Volume 13, Issue No.178Non-coding RNA biomarkers in resistant hypertension: a scoping review抵抗性高血压中的循环非编码RNA生物标志物：一项范围综述DOI: 10.3389/fmolb.2026.1786399
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.179Real-World Effectiveness and Safety of Imeglimin in Type 2 Diabetes: Prospective Multi-Center Study in Bangladesh伊格列净在2型糖尿病中的真实世界观察性研究——孟加拉国患者DOI: 10.2147/DMSO.S576436
Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.180Significant shortening of leukocyte telomeres one year after childbirth in women with type 1 diabetes mellitus: a prospective cohort study1型糖尿病女性分娩后一年内白细胞端粒显著缩短：一项前瞻性队列研究DOI: 10.3389/fcdhc.2026.1776531
Journal of inflammation research IF: 04.100Volume 19, Issue No.181Diagnosis and Management of Comorbid Autoimmune Disorders in Children with Chronic Spontaneous Urticaria儿童慢性自发性荨麻疹患者合并自身免疫性疾病的诊断与管理DOI: 10.2147/JIR.S558731
Frontiers in veterinary science IF: 02.900Volume 13, Issue No.182Case Report: Bexagliflozin as an adjunct decongestive strategy in a cat with congestive heart failure and advanced chronic kidney disease病例报告：贝格列净作为伴充血性心力衰竭和晚期慢性肾脏病猫的辅助减充血策略DOI: 10.3389/fvets.2026.1791139
FCVM IF: 02.900Volume 12, Issue No.183Safety and efficacy of physical activity in hypertrophic cardiomyopathy patients: a systematic review and metanalysis肥厚型心肌病患者的运动：安全性和有效性的荟萃分析DOI: 10.3389/fcvm.2025.1739956
Kidney international reports IF: 05.700Volume 11, Issue 5No.184Cystatin C Confirms the Canagliflozin eGFR Slope Benefit in CANPIONE卡格列净对基于胱抑素C的估算肾小球滤过率斜率的影响DOI: 10.1016/j.ekir.2026.106374
Circulation IF: 38.600Ahead of Print.No.185Effect of APOC3 Inhibition with Olezarsen on Coronary Atherosclerosis: Essence-TIMI 73b Imaging Study奥雷沙恩抑制载脂蛋白C-III对冠状动脉粥样硬化的影响：Essence-TIMI 73b成像研究DOI: 10.1161/CIRCULATIONAHA.126.080012
Frontiers in nutrition IF: 05.100Volume 13, Issue No.186Potential lipid-lowering effects of Coffea arabica pulp extract product in hyperlipidemia-obese subjects: a randomized double-blind placebo-controlled trial绿原酸富集的咖啡果渣提取物改善高脂血症和肥胖成人的脂质谱：一项随机、双盲、安慰剂对照试验DOI: 10.3389/fnut.2026.1755054
Curēus IF: 01.300Volume 18, Issue 2No.187Holmes Tremor Secondary to a Brainstem Haemorrhage With Partial Symptomatic Improvement Following Levetiracetam Use左乙拉西坦使用后部分症状改善的脑干出血继发霍姆斯震颤DOI: 10.7759/cureus.104226
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.188Gabapentin CNS exposure and analgesic response are modulated by OCT2 genotype in patients with chronic neuropathic pain加巴喷丁中枢神经系统暴露和镇痛反应受慢性神经病理性疼痛患者中OCT2基因型调节DOI: 10.3389/fphar.2026.1760901
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.189GLP-1 Receptor Agonist Therapy in Older Adults with Diabetes: A Qualitative Analysis of Phase 4 ClinicalTrials.gov StudiesGLP-1受体激动剂在2型糖尿病老年患者中的应用：4期临床试验的定性分析DOI: 10.2147/DMSO.S584052
NEJM IF: 78.500Ahead of Print.No.190IVUS-Guided versus Angiography-Guided PCI in Unprotected Left Main Coronary Disease血管内超声引导与血管造影引导在无保护左主干冠状动脉疾病中的经皮冠状动脉介入治疗比较DOI: 10.1056/NEJMoa2600440
Current obesity reports IF: 11.000Volume 15, Issue 1No.191Beyond the Scale: Setting Goals for Outcomes Beyond Weight in Evidence-based Obesity Treatment超越体重秤：在循证肥胖治疗中设定超越体重的结局目标DOI: 10.1007/s13679-026-00706-7
Rev Endocr Metab Disord IF: 08.000Ahead of Print.No.192Hypothalamus-liver talks: whispers in the language of metabolism下丘脑-肝脏对话：代谢语言中的低语DOI: 10.1007/s11154-026-10031-y
J Comput Aided Mol Des IF: 03.100Volume 40, Issue 1No.193In silico and in vitro study for the limonoid isolated from Swietenia macrophylla as potential α-glucosidase inhibitor桃花心木中分离的柠檬苦素作为潜在α-葡萄糖苷酶抑制剂的计算机和体外研究DOI: 10.1007/s10822-026-00785-7
Journal of molecular modeling IF: 02.500Volume 32, Issue 4No.194Quantum modeling of Stokes-Induced Stark Fields in quercetin-ZnO nanohybrids for bias-free bioelectric repair of chronic diabetic foot ulcers槲皮素-ZnO纳米杂化物中Stokes诱导斯塔克场的量子建模用于慢性糖尿病足溃疡的无偏生物电修复DOI: 10.1007/s00894-026-06693-9
Clinical Research in Cardiology IF: 03.700Ahead of Print.No.195Impact of the invasively measured flow-gradient pattern on clinical outcomes and ventricular remodeling after transcatheter aortic valve implantation in patients with severe aortic stenosis and preserved ejection fraction射血分数保留的重度主动脉瓣狭窄患者经导管主动脉瓣置换术后，有创测量的血流梯度模式对临床终点及心室重构的影响DOI: 10.1007/s00392-026-02881-y
Clinical Research in Cardiology IF: 03.700Ahead of Print.No.196Impact of residential noise pollution on early-onset myocardial infarction risk results from the DECIBEL-MI (Determination of Environmental CIty-noise's Burden, Exposure, and Link to Myocardial Infarction) study居住噪声污染对早发性心肌梗死风险的影响——DECIBEL-MI研究结果DOI: 10.1007/s00392-026-02902-w
Clinical Research in Cardiology IF: 03.700Ahead of Print.No.197Impact of catheter ablation for atrial fibrillation on cardiac ventricular electrical activity: assessment of premature ventricular complex burden导管消融对心房颤动的心脏心室电活动的影响：室性早搏负荷评估DOI: 10.1007/s00392-026-02906-6
Inflammopharmacology IF: 05.300Ahead of Print.No.198Enhanced wound healing in diabetic rats using Boswellia serrata Roxb.- Zn gel: a multifunctional approach targeting inflammation, oxidative stress, and tissue regeneration使用乳香提取物-锌凝胶增强糖尿病大鼠伤口愈合：针对炎症、氧化应激和组织再生的多功能方法DOI: 10.1007/s10787-026-02214-5
Infectious diseases and therapy IF: 05.300Ahead of Print.No.199Respiratory Syncytial Virus Immunization Strategies for Older Adults in Gulf Cooperation Council Countries: Expert Consensus and Recommendations海湾合作委员会国家老年人呼吸道合胞病毒免疫策略：专家共识与建议DOI: 10.1007/s40121-026-01313-8
J Muscle Res Cell Motil IF: 01.700Volume 47, Issue 2No.200Effects of culture media glucose concentration on LHCN-M2 skeletal muscle cell viability, differentiation and metabolic phenotype: a proof-of-concept study培养基葡萄糖浓度对LHCN-M2骨骼肌细胞活力、分化及代谢表型的影响：一项概念验证研究DOI: 10.1007/s10974-026-09729-y
Pancreas IF: 01.700Ahead of Print.No.201Whole Metagenomic Profiling Identifies a Gut Microbial Signature for Chronic Pancreatitis via Machine Learning全宏基因组分析通过机器学习识别慢性胰腺炎的肠道微生物特征DOI: 10.1097/MPA.0000000000002618
Kidney360 IF: 03.000Volume 7, Issue 3No.202Erosion of Immune Regulation in Diabetic Kidney Disease糖尿病肾病中免疫调节的侵蚀DOI: 10.34067/KID.0000001182
Journal of Alzheimer's disease IF: 03.100Ahead of Print.No.203The ABOARD-RWD infrastructure: Using linked real-world data to study the diagnosis and management of dementiaABOARD-RWD基础设施：利用链接的真实世界数据研究痴呆症的诊断与管理DOI: 10.1177/13872877261429858
Alcohol and alcoholism : IF: 02.200Volume 61, Issue 3No.204Moderate-to-heavy habitual alcohol use appears to be detrimentally associated with inflammation even when accounting for diet quality in humans: findings from an observational intensive longitudinal study中度至重度习惯性饮酒即使在考虑饮食质量时也与炎症呈不利关联：一项观察性强化纵向研究的结果DOI: 10.1093/alcalc/agag015
The Journal of school health IF: 01.800Volume 96, Issue 5No.205Evaluation of the Impact of a Psychoeducational Program on Type 1 Diabetes in Italian Schools: A Pre-Post Study评估心理教育项目对意大利学校1型糖尿病的影响：一项前后测研究DOI: 10.1111/josh.70141
The Journal of rural health IF: 02.700Volume 42, Issue 2No.206Barriers to consulting for symptoms of possible colorectal cancer among rural patients in England: A cross-sectional survey英格兰农村患者对可能结直肠癌症状咨询的障碍：一项横断面调查DOI: 10.1111/jrh.70142
Advanced materials IF: 26.800Ahead of Print.No.207AI-Guided 4D Printing of Carnivorous Plants-Inspired Microneedles for Accelerated Wound HealingAI引导的4D打印受食肉植物启发的微针用于加速伤口愈合DOI: 10.1002/adma.202523665
Wound repair and regeneration IF: 03.400Volume 34, Issue 2No.208Comparative Efficacy of Platelet-Rich Plasma, Platelet-Rich Fibrin, and Conventional Therapy in Chronic Non-Healing Skin Ulcers: A Randomised Clinical Trial富血小板血浆、富血小板纤维蛋白与常规治疗在慢性难愈性皮肤溃疡中的比较有效性：一项随机临床试验DOI: 10.1111/wrr.70151
Nephrol Dial Transplant IF: 05.600Ahead of Print.No.209Better cardiorenal protection for patients with CKD and type 1 diabetes对慢性肾病合并1型糖尿病患者更好的心肾保护DOI: 10.1093/ndt/gfag076
J Am Coll Surg IF: 03.400Ahead of Print.No.210Unraveling Metabolic Syndrome解读代谢综合征DOI: 10.1097/XCS.0000000000001952
J Prim Care Community Health IF: 02.500Volume 17, Issue No.211Self-Reported Depression, Anxiety, Stress, Health-Related Quality of Life, and Diabetes Distress During a 2-Year Pedometer-Based Physical Activity Intervention in Prediabetes and Type 2 Diabetes: Secondary Outcomes of a Randomized Controlled Trial针对前驱糖尿病和2型糖尿病患者的为期2年基于计步器的体力活动干预中自我报告的抑郁、焦虑、压力、健康相关生活质量及糖尿病困扰：随机对照试验的次要结局DOI: 10.1177/21501319261434134
Am J Physiol Renal Physiol IF: 03.400Ahead of Print.No.212NBL1 Associates with Renal Phenotypes in Mice, but Partial Nbl1 Reduction Does Not Ameliorate Kidney DiseaseNBL1与小鼠肾脏表型相关，但部分Nbl1减少并不能改善肾脏疾病DOI: 10.1152/ajprenal.00465.2025
J Geriatr Psychiatry Neurol IF: 02.500Ahead of Print.No.213The Role of Posttraumatic Stress Disorder as a Risk Factor for Dementia: A Meta-Analysis创伤后应激障碍作为痴呆风险因素的作用：一项荟萃分析DOI: 10.1177/08919887261435186
Pancreas IF: 01.700Ahead of Print.No.214Longitudinal Study of Comorbidities and Clinical Outcomes in Persons With Pancreatic Disease Using Electronic Health Records使用电子健康记录对胰腺疾病患者的合并症及临床结局进行纵向研究DOI: 10.1097/MPA.0000000000002636
East Mediterr Health J IF: 01.900Volume 32, Issue 3No.215The urgency of addressing the physical inactivity crisis in the Eastern Mediterranean Region解决东地中海地区体力不活动危机的紧迫性DOI: 10.26719/2026.32.3.127
Gut microbes reportsVolume 2, Issue 1No.216Alterations in gut microbiota characteristics along a type 2 diabetes risk gradient linked with family history与家族史相关的2型糖尿病风险梯度中肠道菌群组成DOI: 10.1080/29933935.2025.2527766
Gut microbes reportsVolume 2, Issue 1No.217Toxic metals impact gut microbiota and metabolic risk in five African-origin populations非洲起源个体中的有毒金属暴露、肠道微生物群与心脏代谢风险DOI: 10.1080/29933935.2025.2481442
Frontiers in big data IF: 02.300Volume 9, Issue No.218FunduScope: a human-centered, machine learning-based interactive tool for training junior ophthalmologists in diabetic retinopathy detectionFunduScope：一种以人为主导、基于机器学习的交互式工具，用于培训初级眼科医生进行糖尿病视网膜病变检测DOI: 10.3389/fdata.2026.1676922
Food Science and Biotechnology IF: 03.100Volume 35, Issue 5No.219Multifaceted role of plant polyphenols in human health: a comprehensive review植物多酚在人类健康中的多方面作用：综述DOI: 10.1007/s10068-025-01991-z
Curēus IF: 01.300Volume 18, Issue 2No.220When Drainage is Not Enough in Emphysematous Pyelonephritis Complicated by Necrotizing Fasciitis: A Case Report气肿性肾盂肾炎并发坏死性筋膜炎时引流不足：一例报告DOI: 10.7759/cureus.104189
Journal of Cardiac Failure IF: 08.200Ahead of Print.No.221Fat Distribution and Postural Changes in Pulmonary Capillary Wedge Pressure in Patients with Obesity and HFpEF肥胖和射血分数保留的心力衰竭（HFpEF）患者的脂肪分布与肺毛细血管楔压的体位变化DOI: 10.1016/j.cardfail.2026.03.029
JACC: Clinical Electrophysiology IF: 07.700Ahead of Print.No.222The Liraglutide Effects in Atrial Fibrillation (LEAF) Study利拉鲁肽对心房颤动（LEAF）研究的影响DOI: 10.1016/j.jacep.2026.03.026
World journal of surgery IF: 02.500Ahead of Print.No.223Enhanced Recovery After Surgery (ERAS) Protocol for Abdominal Wall Reconstruction. A Scoping Review of Items Included in Current Protocols腹部重建术后的加速康复（ERAS）方案：当前方案中包含项目的范围综述DOI: 10.1002/wjs.70356
Diabetic medicine IF: 03.400Ahead of Print.No.224'Darkness as we face the unknown': Biopsychosocial-spiritual experiences of parents of children and young people with type 1 diabetes from the Middle East and North Africa (MENA) region面对未知的黑暗：中东和北非（MENA）地区患有1型糖尿病的儿童和青少年的父母的生物-心理-社会-精神体验DOI: 10.1111/dme.70303
Journal of neurochemistry IF: 04.000Volume 170, Issue 4No.225How Glutamate and GABA «Became» Neurotransmitters: Personal Account of a 65 Years' Voyage谷氨酸和GABA如何“成为”神经递质：一位研究者65年的历程自述DOI: 10.1111/jnc.70325
Clinical endocrinology IF: 02.400Ahead of Print.No.226Apparent Bilateral Aldosterone Suppression During Adrenal Vein Sampling: An Artefact of the Liaison Chemiluminescence Immunoassay and Other Causes Revealed by Comparisons With Another Commercial Immunoassay and Mass Spectrometry肾上腺静脉取样期间的明显双侧醛固酮抑制：Liaison化学发光免疫分析法的假象及与另一种商业免疫分析法和质谱法比较揭示的其他原因DOI: 10.1111/cen.70135
World J Biol Psychiatry IF: 03.800Ahead of Print.No.227Effect of appetite hormone dysregulation on symptom trajectory in adolescents with attention deficit hyperactivity disorder: an exploratory prospective study食欲激素失调对青少年注意力缺陷多动障碍症状轨迹的影响：一项探索性前瞻性研究DOI: 10.1080/15622975.2026.2646508
ANZ journal of surgery IF: 01.600Ahead of Print.No.228Patient Reported Outcomes After Total Pancreatectomy With Islet Autotransplantation: A Narrative Review全胰腺切除联合胰岛自体移植术后患者报告结局：一项叙事综述DOI: 10.1111/ans.70638
Ann Agric Environ Med IF: 01.200Volume 33, Issue 1No.229Multifactorial influence of type 2 diabetes on cardiovascular risk assessed by PolSCORE, SCORE2 in the age group 40-69 years2型糖尿病对40-69岁人群心血管风险的多因素影响（PolSCORE与SCORE2评估）DOI: 10.26444/aaem/205804
Pediatric obesity IF: 02.700Volume 21, Issue 4No.230Metabolic Complications and Ultrasound-Detected Liver Abnormalities in Paediatric Patients With Duchenne Muscular Dystrophy杜氏肌营养不良症患儿的代谢并发症及超声检测的肝脏异常DOI: 10.1111/ijpo.70106
Int J Soc Psychiatry IF: 02.700Ahead of Print.No.231Disordered Eating in Patients With Remission Schizophrenia: A Highly Prevalent but Largely Under-Explored Condition Despite Its Potential Relation to Psychopathology缓解期精神分裂症患者的进食障碍：一种高度流行但在很大程度上未被充分探索的疾病，尽管其可能与精神病理学相关DOI: 10.1177/00207640261424409
Gut microbes IF: 11.000Volume 18, Issue 1No.232Dysregulated eating behaviour and microbiota-based interventions targeting eating disorders and food addiction进食行为失调与针对进食障碍和食物成瘾的基于微生物群的干预措施DOI: 10.1080/19490976.2026.2647535
Pediatric obesity IF: 02.700Volume 21, Issue 4No.233Associations of Maternal Pre-Pregnancy BMI With Frontostriatal Connectivity in Young Children母亲孕前BMI与幼儿前额纹状体连接性的关联DOI: 10.1111/ijpo.70101
Medical science monitor IF: 02.100Volume 32, Issue No.234Social Attitudes Towards Public Health Interventions in Community Pharmacies in Poland: A Nationwide Cross-Sectional Survey波兰社区药房公共卫生干预措施的社会态度：全国横断面调查DOI: 10.12659/MSM.951732
Journal of neurochemistry IF: 04.000Volume 170, Issue 4No.235Cocaine-Induced Immediate-Early Gene Expression in the Nucleus Accumbens: Roles of Separate cAMP Sensors可卡因诱导伏隔核中即早基因表达：不同cAMP传感器的作用DOI: 10.1111/jnc.70374
Aust N Z J Obstet Gynaecol IF: 01.700Volume 66, Issue 2No.236Perinatal Outcomes After Sleeve Gastrectomy Compared to a Matched Control Group减重手术后妊娠的围产期结局与匹配对照组比较DOI: 10.1111/ajo.70117
Wound repair and regeneration IF: 03.400Volume 34, Issue 2No.237Autologous Blood Clot Therapy for Wounds: Investigating the Chemotactic Effect on PBMCs and Fibroblasts in Diabetes自体血凝块疗法治疗伤口：研究其对糖尿病患者外周血单核细胞和成纤维细胞的趋化作用DOI: 10.1111/wrr.70153
European journal of neurology IF: 03.900Volume 33, Issue 4No.238Subjective Memory Impairment in the General Adult Population: Associations With Early-Life Cognition, Concurrent Objective Memory, Dementia Risk Factors普通成年人群中的主观记忆障碍：与早年认知、同期客观记忆及痴呆风险因素的关联DOI: 10.1111/ene.70556
European journal of pain IF: 03.400Volume 30europeanjournalofpain, Issue 4, Page e70252-e70262No.239Short-Term Sleep Disruption Does Not Modify Responses to Experimentally Induced Knee Pain in Healthy Individuals短期睡眠中断不会改变健康个体对实验性膝关节疼痛的反应DOI: 10.1002/ejp.70260
Ann Agric Environ Med IF: 01.200Volume 33, Issue 1No.240Effect of overweight and obesity on clinical course and prognosis in patients with acute coronary syndromes超重和肥胖对急性冠脉综合征患者临床进程及预后的影响DOI: 10.26444/aaem/213894
Journal of food science IF: 03.400Volume 91, Issue 4No.241A Critical Review of Antidiabetic Properties of Tempeh From Various Substrates各种底物发酵天贝的抗糖尿病特性批判性综述DOI: 10.1111/1750-3841.71014
Clinical toxicology IF: 03.300Ahead of Print.No.242Recommendations from the Clinical Toxicology Recommendations Collaborative on the administration of activated charcoal in acute oral overdose临床毒理学推荐协作组关于急性口服过量中毒中活性炭给药的建议DOI: 10.1080/15563650.2025.2609807
Hypertension IF: 08.200Ahead of Print.No.243Dietary Sodium-Regulated Plasma SVEP1 and Inverse Salt Sensitivity饮食钠调节的血浆SVEP1与反向盐敏感性DOI: 10.1161/HYPERTENSIONAHA.125.26827
Natural product research IF: 01.600Ahead of Print.No.244Harnessing mangroves for epigenetic therapies利用红树林进行表观遗传疗法DOI: 10.1080/14786419.2026.2649921
Brain : IF: 11.700Ahead of Print.No.245Synapse-associated neuropathological markers in Alzheimer disease阿尔茨海默病中突触相关的神经病理标志物DOI: 10.1093/brain/awag117
European Journal of Immunology IF: 03.700Volume 56, Issue 4No.246Systemic Type I Interferon Blockade Mitigates Insulin Resistance in a Preclinical Model of Psoriasis系统性I型干扰素阻断可减轻银屑病临床前模型中的胰岛素抵抗DOI: 10.1002/eji.70160
The FASEB journal : IF: 04.200Volume 40, Issue 7No.247Obesity Disrupts H3K4me3-Mediated Lactate Accumulation and Efferocytosis in Hypoxic Macrophages肥胖破坏缺氧巨噬细胞中H3K4me3介导的乳酸积累和胞葬作用DOI: 10.1096/fj.202502626R
Journal of health psychology IF: 02.200Ahead of Print.No.248Technology readiness associated with insulin pump and automated insulin delivery system use in young adults with type 1 diabetes与1型糖尿病青年成年人胰岛素泵及自动化胰岛素递送系统使用相关的技术准备度DOI: 10.1177/13591053261433230
Diabetic medicine IF: 03.400Ahead of Print.No.249Exploring inequities in access to diabetes technologies among children and young people with type 1 diabetes: Perspectives of parents and young people from ethnic minority groups and low socio-economic areas探索1型糖尿病儿童和青少年获取糖尿病技术的不平等：少数族裔及低社会经济区域群体父母与青少年的视角DOI: 10.1111/dme.70304
Medeniyet medical journal IF: 01.100Volume 41, Issue 1No.250Impact of SARS-CoV-2 Infection on Diabetic Ketoacidosis in Children with Newly Diagnosed Type-1 Diabetes: A Prospective Multicenter Study严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染对新诊断1型糖尿病儿童糖尿病酮症酸中毒的影响：一项前瞻性多中心研究DOI: 10.4274/MMJ.galenos.2026.55256
211
Diabetes Mellitus(DM)
糖尿病
103
Obesity
肥胖症
70
Insulin
胰岛素
32
Type 2 diabetes mellitus(T2DM)
2型糖尿病
18
Metformin
二甲双胍
16
Diabetic Kidney Disease(DKD)
糖尿病肾脏病
13
Metabolic Syndrome
代谢综合征
13
Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA)
胰高血糖素样肽-1受体激动剂
8
Semaglutide
司美格鲁肽
8
Gestational Diabetes Mellitus(GDM)
妊娠糖尿病
7
Hypoglycemic Agents
降糖药
7
Diabetic Retinopathy
糖尿病视网膜病
5
Diabetic Foot
糖尿病足
5
Liraglutide
利拉鲁肽
4
Tirzepatide
替尔泊肽
3
Dulaglutide
度拉糖肽
3
Diabetes Complications
糖尿病并发症
2
Diabetic Cardiomyopathies
糖尿病心肌病
2
gamma-Aminobutyric Acid(GABA)
γ-氨基丁酸
2
Gabapentin
加巴喷丁
2
Exenatide
艾塞那肽
2
Type 1 diabetes mellitus(T1DM)
1型糖尿病
1
Dipeptidyl-Peptidase IV Inhibitors(DPP-4i)
二肽基肽酶-4抑制剂
1
Sitagliptin
西他列汀
1
Albiglutide
阿必鲁肽
1
Lixisenatide
利司那肽
1
Diabetic Peripheral Neuropathy(PDN)
糖尿病周围神经病变
1
Diabetic Neuropathies
糖尿病性神经病变
1
Diabetic acidosis
糖尿病性酸中毒
1
Bexagliflozin
贝沙格列净
1
Canagliflozin
卡格列净
1
Dapagliflozin
达格列净
编辑：韩玉莲
审校：韩玉莲
临床结果临床3期
100 项与 卡格列净 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 2型糖尿病肾脏病 | 日本 | 2022-06-20 | |
| 糖尿病肾病 | 美国 | 2019-09-27 | |
| 2型糖尿病 | 美国 | 2013-03-29 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 心脏衰竭 | 临床3期 | 美国 | 2020-03-10 | |
| 射血分数保留型心力衰竭 | 临床3期 | 美国 | 2020-03-10 | |
| 射血分数降低的心力衰竭 | 临床3期 | 美国 | 2020-03-10 | |
| 心血管疾病 | 临床3期 | 美国 | 2009-12-09 | |
| 心血管疾病 | 临床3期 | 阿根廷 | 2009-12-09 | |
| 心血管疾病 | 临床3期 | 澳大利亚 | 2009-12-09 | |
| 心血管疾病 | 临床3期 | 比利时 | 2009-12-09 | |
| 心血管疾病 | 临床3期 | 加拿大 | 2009-12-09 | |
| 心血管疾病 | 临床3期 | 哥伦比亚 | 2009-12-09 | |
| 心血管疾病 | 临床3期 | 捷克 | 2009-12-09 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床2期 | 45 | 觸積鑰願網鏇夢觸鬱襯(齋遞網觸顧網遞壓鑰網) = 夢鏇憲構積製築築製構 夢蓋網襯積積淵範憲膚 (衊襯衊廠積壓鑰憲餘鹹 ) 更多 | 积极 | 2026-02-24 | |||
壓繭鏇範築壓淵憲廠築(構窪觸膚憲壓膚衊鏇襯) = 膚築選觸築廠鹹構願膚 淵廠壓夢襯積蓋鏇鏇壓 (衊觸製憲襯膚繭鏇鹽選 ) | |||||||
临床3期 | - | 5,281 | 糧鏇膚蓋醖範鹽鹹襯獵(鏇衊製鏇憲顧鹹遞齋構): HR = 0.65 (95.0% CI, 0.53 ~ 0.79) 更多 | 积极 | 2025-12-01 | ||
Placebo | |||||||
临床3期 | 4,401 | 壓艱憲願蓋顧顧顧醖襯(憲鑰窪糧夢襯膚齋襯網): HR = 0.88 (95.0% CI, 0.8 ~ 0.98), P-Value = 0.02 更多 | 积极 | 2025-09-01 | |||
Placebo | |||||||
临床3期 | 171 | placebo+canagliflozin (Placebo) | 網簾鹹範膚遞鬱獵鑰遞(獵鑰網廠醖淵壓醖簾繭) = 構獵遞淵願觸夢網鬱壓 餘鏇蓋鹹範鑰製齋範襯 (鑰壓選選壓積願選繭願, 0.191) 更多 | - | 2025-03-12 | ||
(Canagliflozin 100/300 mg) | 網簾鹹範膚遞鬱獵鑰遞(獵鑰網廠醖淵壓醖簾繭) = 獵顧獵構糧壓膚顧襯繭 餘鏇蓋鹹範鑰製齋範襯 (鑰壓選選壓積願選繭願, 0.194) 更多 | ||||||
临床3期 | 308 | (Canagliflozin 100mg) | 廠餘壓願廠壓餘鹹鹹範 = 簾壓窪蓋廠鬱糧繭糧遞 積淵夢鹽鏇襯齋鬱鹽襯 (鑰範齋範構淵顧鹹蓋憲, 蓋餘蓋齋壓獵觸選糧糧 ~ 夢觸餘醖糧餘遞遞簾蓋) 更多 | - | 2024-07-15 | ||
Placebo (Placebo) | 廠餘壓願廠壓餘鹹鹹範 = 簾餘壓糧齋積選窪蓋製 積淵夢鹽鏇襯齋鬱鹽襯 (鑰範齋範構淵顧鹹蓋憲, 顧鑰鏇製顧膚構遞鹽範 ~ 顧鹹壓範鬱蓋醖鹽範鏇) 更多 | ||||||
N/A | - | Canagliflozin 100 mg/d | 構襯製網窪壓製壓膚醖(壓遞淵窪餘遞範衊鹽網) = 壓窪蓋範艱衊積顧鬱壓 鏇艱膚淵製築廠鑰網範 (憲繭齋鏇壓窪膚鹹齋夢 ) 更多 | - | 2024-06-14 | ||
N/A | - | SGLT2i | 淵襯構蓋製鏇衊範鑰憲(壓衊艱構廠襯艱醖網構) = 齋鬱繭積鹹壓觸願鏇糧 壓觸獵積齋構簾積鬱構 (簾衊範繭網觸餘糧糧衊, 16.6 ~ 19.7) | 积极 | 2024-06-14 | ||
DPP4i | 淵襯構蓋製鏇衊範鑰憲(壓衊艱構廠襯艱醖網構) = 顧製憲淵齋製顧艱簾糧 壓觸獵積齋構簾積鬱構 (簾衊範繭網觸餘糧糧衊, 19.1 ~ 21.4) | ||||||
N/A | - | 齋鹹鑰築顧憲製製顧構(壓簾網廠獵繭選繭簾衊): HR = 0.83 (95% CI, 0.75 ~ 0.93) 更多 | 积极 | 2023-12-01 | |||
Placebo | |||||||
临床3期 | 2,627 | 糧網淵製窪夢壓糧醖憲(蓋鏇繭遞窪鹹鏇襯繭餘) = 遞構齋衊繭蓋遞積艱積 窪壓憲憲製構鑰簾築衊 (齋憲壓餘遞窪繭獵遞衊 ) 更多 | - | 2023-08-22 | |||
N/A | - | 淵鏇觸獵廠積鹹願簾窪(積鏇憲衊餘顧構壓淵簾) = 憲積壓醖糧鹹衊範鏇築 鑰選夢蓋鬱繭夢鬱選夢 (夢艱鬱醖選網壓選餘願 ) | - | 2023-06-22 |
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