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更新于：2026-10-19
Sitagliptin Phosphate
磷酸西格列汀
更新于：2026-10-19
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 美国 (2006-10-16), |
最高研发阶段(中国)批准上市 |
特殊审评优先审评 (中国) |
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结构/序列
分子式C16H20F6N5O6P |
InChIKeyGQPYTJVDPQTBQC-KLQYNRQASA-N |
CAS号654671-77-9 |
关联
729
项与 磷酸西格列汀 相关的临床试验NCT07804381
A Multicenter, Randomized, Double-blind, Placebo-controlled Phase 2 Trial Evaluating the Disease-modifying Efficacy of Sitagliptin Therapy in Early-stage Parkinson's Disease
Parkinson's disease (PD) is a progressive neurodegenerative disorder pathologically characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta and the accumulation of α-synuclein (α-syn) aggregates. To date, all approved treatments, including levodopa, are primarily limited to symptomatic relief, and no disease-modifying therapy (DMT) has been established to fundamentally slow or halt disease progression.
Large-scale epidemiological cohort studies conducted in Taiwan, Sweden, the United Kingdom, and other countries have consistently reported that, among patients with diabetes, DPP-4 inhibitor users had an approximately 30%-40% lower risk of developing Parkinson's disease compared with non-users.
This study aims to evaluate whether 72 weeks of treatment with sitagliptin (100 mg once daily), compared with placebo, delays the time to confirmed motor progression in patients with early-stage PD receiving stable levodopa monotherapy. Confirmed motor progression is defined as an increase of ≥5 points from baseline in the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III score assessed in the OFF state.
Large-scale epidemiological cohort studies conducted in Taiwan, Sweden, the United Kingdom, and other countries have consistently reported that, among patients with diabetes, DPP-4 inhibitor users had an approximately 30%-40% lower risk of developing Parkinson's disease compared with non-users.
This study aims to evaluate whether 72 weeks of treatment with sitagliptin (100 mg once daily), compared with placebo, delays the time to confirmed motor progression in patients with early-stage PD receiving stable levodopa monotherapy. Confirmed motor progression is defined as an increase of ≥5 points from baseline in the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III score assessed in the OFF state.
开始日期2026-12-15 |
申办/合作机构 |
NCT06560333
Evaluate the Efficacy and Safety of the Combined Use of a Sodium-glucose Cotransporter 2 (iSGLT2) Inhibitor and a Dipeptidyl Peptidase-4 (iDPP -4) Inhibitor in the Treatment of Type 2 Diabetes Mellitus in Patients Treated With Metformin
The present study aims to evaluate the efficacy and safety of different combinations of oral antidiabetics in patients with inadequate glycemic control on metformin monotherapy.
开始日期2026-11-30 |
申办/合作机构 |
CTRI/2026/09/117970
Effectiveness and Tolerability of Fixed Dose Combination FDC of Glimepiride, Metformin and Sitagliptin in Patients with Type 2 Diabetes Mellitus, A Real World Retrospective Study from Electronic Medical Records - NIL
开始日期2026-09-29 |
申办/合作机构- |
100 项与 磷酸西格列汀 相关的临床结果
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100 项与 磷酸西格列汀 相关的转化医学
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100 项与 磷酸西格列汀 相关的专利（医药）
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2,574
项与 磷酸西格列汀 相关的文献（医药）2026-01-02·Expert Opinion On Drug Safety
Exploring SGLT-2 inhibitors and sarcopenia in FAERS: a post-marketing surveillance study
Article
作者: Tang, Guowen ; Yuan, Jie ; Ye, Yangli ; Kuai, Zheng ; Zhang, Xiaoyi ; Gao, Lihong
BACKGROUND:
The sodium-dependent glucose transporters 2 inhibitors (SGLT-2i) is associated with body weight loss but the composition of the losing weight remains unclear.
RESEARCH DESIGN AND METHODS:
Disproportionality analyses, including the reporting odds ratio (ROR), the proportional reporting ratio (PRR), the Bayesian confidence propagation neural network (BCPNN), and the multi- item gamma Poisson shrinker (MGPS) algorithms, were employed to quantify the signals of SGLT-2i-associated musculoskeletal and connective tissue disorders AEs.
RESULTS:
The search retrieved a total of 3,206 cases of musculoskeletal and connective tissue disorder-related AEs during the reporting period. This included 1,061 cases for Canagliflozin, 1,052 cases for Dapagliflozin, 1,074 cases for Empagliflozin, and 19 cases for Ertugliflozin. Fifteen preferred terms (PTs) with significant disproportionality were retained. No musculoskeletal and connective tissue system-related AE signals were reported for Ertugliflozin. We identified a risk of muscle necrosis with Canagliflozin use, a risk of sarcopenia with Dapagliflozin use, and a chance of muscle atrophy with Dapagliflozin and Empagliflozin prescriptions. Most cases occurred within the first month after SGLT-2i initiation, and AEs can persist beyond 360 days of use.
CONCLUSIONS:
Our study identified potential new musculoskeletal and connective tissue disorder-related AE signals associated with SGLT-2 inhibitors.
2026-01-01·LUMINESCENCE
Simple and Novel Fluorimetric Protocol for Sitagliptin Estimation Through Sensitivity Enhancement Using Acetic Acid: Application to Pharmaceutical Dosage Form With Green Assessment
Article
作者: Shahin, Reem Y. ; Noureldeen, Deena A. M. ; Attia, Tamer Z. ; Taha, Hager M.
ABSTRACT:
A simple, cost‐effective, reproducible, highly sensitive, and green spectrofluorimetric technique for sitagliptin phosphate estimation has been established in its pure form and commercial formulation. The native fluorescence of sitagliptin was enhanced by inhibiting photoinduced electron transfer through optimization of medium pH. The highest fluorescence intensity of sitagliptin was observed at 296 and 583 nm after excitation at 265 nm, using 0.50‐M acetic acid. The method exhibited a wide linearity range (0.30–4.00 μg/mL) with high correlation coefficient values of 0.9998 at both 296 and 583 nm, limits of detection of 0.09 and 0.10 μg/mL, and the limits of quantitation of 0.27 and 0.29 μg/mL, respectively. The guidelines of ICH have been applied for validation of the proposed method. The obtained results have been compared with the previous reported methods. The developed fluorimetric protocol demonstrated high accuracy and excellent precision for estimation of sitagliptin in commercial tablets. Furthermore, the method was confirmed to be environmentally friendly using AGREE, GAPI, Analytical Eco‐Scale, MA, and AGSA tools. As a conclusion, the proposed fluorimetric protocol is highly suitable for the quality control of sitagliptin phosphate.
2026-01-01·BIOMEDICAL CHROMATOGRAPHY
From Separation to Safety Prediction: Validated RP‐HPLC Method for Simultaneous Estimation of Sitagliptin and Lobeglitazone, LC‐MS/MS Identification of Degradant Products, and In Silico Safety Profiling
Article
作者: Prajapati, Viraj ; Patel, Rutvi ; Shah, Kushal ; Thummar, Kashyap ; Panchal, Gaurav ; Moradia, Akshita
ABSTRACT:
Diabetes mellitus is a global health burden, necessitating effective combination therapies. The fixed‐dose formulation of sitagliptin phosphate (SGP, 100 mg) and lobeglitazone sulfate (LGS, 0.5 mg) offers synergistic benefits by enhancing insulin sensitivity and glucose‐dependent insulin secretion. However, simultaneous quantification remains challenging due to their dosage disparity and the narrow therapeutic index of LGS. This study reports a validated, stability‐indicating RP‐HPLC method for concurrent estimation of SGP and LGS in a synthetic mixture. Separation was achieved on a Pursuit 5 Diphenyl column (150 × 4.6 mm, 5 μm) using a gradient of 0.1% formic acid and acetonitrile at 1.0 mL/min, with PDA detection at 254 nm. The method complied with ICH Q2(R2) guidelines, showing specificity, linearity, accuracy, precision, and robustness. Forced degradation studies revealed marked instability of SGP under acidic and alkaline conditions, whereas LGS remained stable. LC‐MS/MS analysis identified a major degradation product at
m
/
z
234, and probable fragmentation pathways were proposed. In silico ADMET and toxicity profiling predicted high gastrointestinal absorption for all degradation products, with PI‐1 and PI‐2 flagged for carcinogenicity and all except PI‐3 showing nephrotoxicity. This integrated analytical–computational approach provides a reliable tool for quality control and safety assessment of this antidiabetic formulation.
715
项与 磷酸西格列汀 相关的新闻（医药）2026-10-16
Di-tert-butyl dicarbonate (Boc₂O, CAS: 24424-99-5) is often simply described as an “amine protecting reagent,” but in the eyes of pharmaceutical R&D engineers, it is the driving force behind numerous blockbuster drugs. Shunxiang Pharmaceutical has combed through publicly available data from overseas journals and patents to show how this classic reagent underpins the synthetic routes of several star drugs.
GLP-1 Weight-Loss and Anti-Diabetic Drugs
Semaglutide (Ozempic/Wegovy) and tirzepatide (Zepbound/Mounjaro), both GLP-1 receptor agonists, are among the most closely watched metabolic drugs worldwide. In their solid-phase synthesis, the ε-amino group of the lysine side chain is commonly protected using the Boc strategy, with Fmoc-Lys(Boc)-OH and Boc-Lys(Boc)-OH recognized as key intermediates; European Patent EP3398960 also explicitly records the use of Boc-type amino acids such as Boc-His(Trt)-OH as raw materials for the preparation of semaglutide. Stable under basic coupling conditions and readily cleaved by acid, the Boc group precisely meets the needs of stepwise assembly and side-chain modification of long-chain peptides.
Anti-Cancer Drug Docetaxel
Docetaxel (Taxotere) is a classic anti-tumor drug. According to the Journal of Organic Chemistry, its key chiral side chain can be efficiently constructed from Boc-benzylamine in just three steps via dilithiation, enal addition, and oxidation. Here, Boc serves not only as an amine protecting group but also stabilizes the key intermediate through negative charge on nitrogen, providing a concise route to stereoselective synthesis of the side chain, delivering an esterification-ready side chain skeleton from Boc-benzylamine in only three steps.
Anti-Viral Drug Intermediates
In the synthesis of the HCV NS3 protease inhibitor BILN 2061 reported by Boehringer Ingelheim in the Journal of Organic Chemistry, the key building block vinyl-ACCA (1-amino-2-vinylcyclopropanecarboxylic acid) was prepared via a route based on Boc-protected glycine derivatives, achieving enantiomeric purity exceeding 99% ee and successful multikilogram scale-up—a representative case of the Boc strategy supporting industrial production of complex unnatural amino acids.
Antibiotic and Anti-Diabetic Drug Intermediates
In the cephalosporin field, the 7β-Boc-amino cephalosporin intermediates (Boc-ACLE and Boc-ACLH) are constructed in one step via Boc protection with SiO₂ catalysis and ultrasonic assistance, achieving isolated yields of 96% and 96.2%, respectively (Journal of Chemistry). The key intermediate of DPP-4 class anti-diabetic drugs (e.g., sitagliptin), 3-(R)-Boc-amino-4-(2,4,5-trifluorophenyl)butanoic acid, likewise relies on Boc-protected amino acid esters as core raw materials (Synthetic Communications).
Conclusion
From GLP-1 metabolic drugs to anti-tumor, anti-viral, and antibiotic products, Boc anhydride is deeply embedded in modern drug synthesis chains through its mild and controllable protecting-group chemistry. Shunxiang Pharmaceutical supplies high-purity di-tert-butyl dicarbonate with consistent batch quality and controlled impurities, providing reliable support for peptide and pharmaceutical intermediate production.
2026-10-15
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截至10月15日15点59分，近期共有 569 本期刊发布了 1113 篇文章，其中糖尿病相关的文章共 289 篇，覆盖 40 个领域的内容。中国专家参与发表的文章有 72 篇。今日，影响因子最高的文章刊登在 The New England Journal of Medicine (IF: 78.500) 期刊上。
今日头条
Headlines
01 Journal of diabetes research IF: 03.400 韩国家庭共餐与无糖尿病成人糖尿病前期的关联研究
Eun-Ji Jung, Jae Hyeok Lim, Kui Son Choi, Min Jin Ha, Eun-Cheol Park, etc.
糖尿病前期是一种可逆转但常被忽视的疾病状态，是早期干预的关键窗口。家庭共餐行为可能有助于该阶段的疾病管理。本研究旨在探讨韩国家庭共餐行为与成人糖尿病前期患病率之间的关联。
研究分析了2019年至2023年韩国国民健康与营养调查的数据。家庭共餐被定义为每周至少三次与家人共享至少一餐（早餐、午餐或晚餐）。糖尿病前期定义为空腹血糖100-125 mg/dL或糖化血红蛋白（HbA1c）5.7%-6.4%。研究采用性别分层多变量logistic回归分析，并校正了协变量。
研究共纳入16,957名无糖尿病的成人，其中男性6,907名，女性10,050名。糖尿病前期患病率在男性中为49.1%，在女性中为42.3%。参与家庭共餐的男性相比不参与的男性，糖尿病前期风险降低16%（比值比[OR]：0.84，95%置信区间[CI]：0.73-0.97）。而在女性中，这种相关性不显著（OR：0.97，95% CI：0.84-1.11）。在男性中，这种相关性在城市居住、较高家庭收入、较高教育水平、白领职业和已婚状态的社会经济亚组中更为明显。
研究结论指出，定期参与家庭共餐与韩国无糖尿病成年男性较低的糖尿病前期患病率相关。这一发现可能有助于识别可从针对性生活方式干预中获益的人群亚组，以预防糖尿病。
本文由 韩玉莲 编辑
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Journal of diabetes research | Volume 2026, Issue 1
10.1155/jdr/7457214
02 Frontiers in pharmacology IF: 04.800 司美格鲁肽与利拉鲁肽的适应症特异性不良事件特征：一项FAERS比例失衡分析
Samuel A Fisch, Eitan J Neugut, Nicole Cornet, Daniela Quigee, Alfred I Neugut, Daniel E Freedberg, etc.
一项基于FDA不良事件报告系统（FAERS）的比例失衡分析，比较了司美格鲁肽和利拉鲁肽在2型糖尿病和肥胖适应症下的不良事件特征。研究分析了2021年至2025年第三季度的8,213,105份报告，最终纳入33,259份。
结果显示，司美格鲁肽和利拉鲁肽均表现出胃肠道不良事件信号。司美格鲁肽在两种适应症中均显示出胃肠道动力减慢的信号，特别是胃排空受损（2型糖尿病：ROR 8.35，95%CI 1.16-59.97；肥胖：ROR 4.01，95%CI 2.12-7.58）。利拉鲁肽则显示出更严重的胃肠道不良事件信号，包括2型糖尿病中的腹胀（ROR 1.46，95%CI 1.12-1.91）和肥胖中的胰腺炎（ROR 2.90，95%CI 1.91-4.39）。
此外，研究还发现司美格鲁肽与缺血性视神经病变（ROR 4.42，95%CI 1.41-13.87）和自杀意念（ROR 5.98，95%CI 1.24-24.19）等信号相关。与二甲双胍和奥利司他相比，GLP-1RA类药物在胃肠道动力障碍和梗阻性事件方面报告比例更高。
结论指出，司美格鲁肽和利拉鲁肽均与胃肠道动力减慢相关，但司美格鲁肽的胃肠道不良事件报告更多，而利拉鲁肽的胰腺炎和肝损伤报告更多。缺血性视神经病变和自杀意念等信号需谨慎解读，未来需进一步研究因果关系。
本文由 韩玉莲 编辑
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Frontiers in pharmacology | Volume 17, Issue
10.3389/fphar.2026.1936967
03 Frontiers in public health IF: 03.400 归因于肥胖的糖尿病、高血压和心血管疾病的群体负担：一项在Türkiye开展的社区研究
Banu Ersoy Şen, Meltem Yılmaz, Merve Taştan, etc.
肥胖已成为全球公共卫生大流行，其患病率迅速上升，肥胖相关慢性疾病负担日益加重。尽管肥胖患病率高，但诊断率仍然较低，限制了有效的预防和管理。因此，可靠的区域特异性流行病学数据对于指导公共卫生干预和政策制定至关重要。
这项研究旨在调查Türkiye北部Amasya省社区中不同年龄和性别群体的肥胖患病率及其与慢性疾病的关联。研究纳入22,667名成人，其中50.6%为女性，平均年龄46.4±16.1岁。数据收集于2025年6月15日至7月31日期间在实地摊位进行。身高和体重采用标准化程序测量，慢性疾病为自我报告。采用年龄和性别校正的逻辑回归评估肥胖与糖尿病、高血压和心血管疾病的相关性，并进行交互分析，同时计算归因指标。
结果显示，肥胖患病率为29.9%，女性高于男性（35.7% vs. 23.9%）。糖尿病、高血压和心血管疾病的患病率分别为12.1%、16.2%和6.6%，在肥胖个体中显著高于非肥胖个体。校正年龄和性别后，肥胖与糖尿病（aOR=2.88，95% CI 2.65-3.14）、高血压（aOR=2.50，95% CI 2.31-2.70）和心血管疾病（aOR=2.29，95% CI 2.05-2.56）的较高风险相关。肥胖的校正后人群归因分数分别为：糖尿病31.5%、高血压25.8%、心血管疾病26.1%。年龄显著修饰肥胖与所有三种慢性疾病的关联，而未观察到与性别的显著交互作用。
这项基于社区的研究表明，肥胖高度流行，且与糖尿病、高血压和心血管疾病强相关。这些疾病在群体水平上可归因于肥胖的负担巨大，进一步凸显了肥胖作为重大公共卫生问题的重要性。研究结果支持加强基于证据的策略，通过生活方式改变和基于人群的预防方法来促进健康体重。
本文由 韩玉莲 编辑
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Frontiers in public health | Volume 14, Issue
10.3389/fpubh.2026.1963530
04 Frontiers in nutrition IF: 05.100 中国南方儿童肥胖严重程度相关的多维因素：一项横断面研究
Peifeng Zhuang, Bin Lin, Haiqing Li, Jinlu Zheng, Wenlin Tang, Wenbin Ye, etc.
儿童肥胖已成为全球重大公共卫生挑战。2020年全球约有3890万（5.7%）5岁以下儿童受其影响，对儿童身体、心理及代谢健康产生长期影响。然而，关于饮食、行为、家庭及社会经济等多维度可改变因素与儿童肥胖严重程度之间分级关联的证据仍然有限，尤其是在中国东南部地区。
为此，研究人员在中国福建省开展了一项横断面研究，纳入680名学龄儿童（344名男孩和336名女孩，年龄6~16岁）。研究收集了围产期因素、家族体重状况、父母教育水平、膳食摄入、体力活动及睡眠行为等数据，并依据中国国家标准将肥胖严重程度分为四个有序组别，采用有序logistic回归模型估计关联。
研究结果显示，出生体重和婴儿喂养方式与肥胖严重程度无显著关联。母亲照护与女孩较低的肥胖风险相关。家族聚集性显著：父亲肥胖（OR 1.93，95% CI 1.20-3.06）和兄弟姐妹肥胖（OR 2.26，95% CI 1.16-4.29）与儿童肥胖风险显著正相关。父母教育水平越低，儿童肥胖严重程度越高。
在饮食行为方面，早餐频率随肥胖严重程度增加而逐渐下降。午餐和晚餐中，禽肉、海鲜、蔬菜、水果和豆类的摄入量在各组间显著减少。午餐禽肉摄入与较低肥胖风险显著相关（OR 0.558，95% CI 0.354-0.878）。烧烤、冷饮和膨化食品与肥胖风险增加相关（OR 1.763，95% CI 1.096-2.836）。相比之下，坚果（OR 0.477，95% CI 0.282-0.807）和饼干（OR 0.483，95% CI 0.322-0.723）与较低风险显著相关。
在体力活动方面，球类运动（OR 0.457，95% CI 0.227-0.918）和步行（OR 0.368，95% CI 0.180-0.751）与较低肥胖风险显著相关。较晚的就寝时间和较短的睡眠时长与肥胖严重程度相关。
研究结论指出，儿童肥胖严重程度与多种因素相关，包括家族体重状况、父母教育水平、膳食多样性、零食模式、体力活动及睡眠行为。这些发现可为以家庭为中心的多层面儿童肥胖预防策略提供参考。
本文由 韩玉莲 编辑
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Frontiers in nutrition | Volume 13, Issue
10.3389/fnut.2026.1942160
中国发表（72）
China
Journal of chromatography IF: 02.800Volume 1284, Issue No.01Integration multidimensional assessment, bioactivities and chemometrics to study the effect of different drying methods on Trichosanthis Fructus polysaccharides整合多维评估、生物活性和化学计量学方法研究不同干燥方式对瓜蒌多糖的影响DOI: 10.1016/j.jchromb.2026.125318
Trends Endocrinol Metab IF: 12.600Ahead of Print.No.02Hyocholic acid: a primary bile acid regulating lifespan immunometabolism猪胆酸：一种调节寿命免疫代谢的初级胆汁酸DOI: 10.1016/j.tem.2026.09.016
Zhonghua Wei Zhong Bing Ji Jiu Yi XueVolume 38, Issue 9No.03[Correlation between glycemic variability coefficient and sepsis-induced coagulopathy and analysis of risk factors]血糖变异系数与脓毒症诱导凝血病的相关性及危险因素分析DOI: 10.3760/cma.j.cn121430-20260331-00150
Journal of Advanced Research IF: 13.000Ahead of Print.No.04Identifying overlooked factors associated with multidrug-resistant tuberculosis: an ecological study across 201 countries and regions, 1990-2021识别与多重耐药结核病相关的被忽视因素：一项覆盖201个国家和地区、1990-2021年的生态学研究DOI: 10.1016/j.jare.2026.10.028
European journal of pharmacology IF: 04.700Ahead of Print.No.05Effects of Sitagliptin Combined with GTS-21 on Improving Glycemic Control and Diabetic Nephropathy by Anti-Apoptosis in Leprdb/db Mice西格列汀联合GTS-21通过抗凋亡改善Leprdb/db小鼠血糖控制和糖尿病肾病的作用DOI: 10.1016/j.ejphar.2026.179426
Environmental research IF: 07.700Ahead of Print.No.06Association between organophosphate esters and incident type 2 diabetes risk: modification by genetic risk and lifestyle有机磷酸酯与2型糖尿病发病风险的关联：遗传风险与生活方式的修饰作用DOI: 10.1016/j.envres.2026.125923
Diabetes Res Clin Pract IF: 07.400Ahead of Print.No.07Effectiveness of technology-enabled teleophthalmology and emerging retinal imaging techniques for diabetic retinopathy screening: a systematic review and meta-analysis技术赋能的远程眼科和新兴视网膜成像技术在糖尿病视网膜病变筛查中的有效性：系统综述和荟萃分析DOI: 10.1016/j.diabres.2026.113610
Diabetes Res Clin Pract IF: 07.400Ahead of Print.No.08Dapagliflozin and 54-week kidney function in kidney transplant recipients with post-transplant diabetes mellitus: a randomized controlled trial达格列净与肾移植受者移植后糖尿病54周肾功能：一项随机对照试验DOI: 10.1016/j.diabres.2026.113605
Journal of ethnopharmacology IF: 05.400Ahead of Print.No.09Discovery of the mechanism of Huangqi Guizhi Wuwu Decoction in the treatment of Diabetic Peripheral Neuropathy with Qi Deficiency and Blood Stasis based on the dynamic metabolic trajectory analysis基于动态代谢轨迹分析发现黄芪桂枝五物汤治疗气虚血瘀型糖尿病周围神经病变的作用机制DOI: 10.1016/j.jep.2026.122422
Journal of ethnopharmacology IF: 05.400Ahead of Print.No.10Agriophyllum squarrosum oligosaccharides ameliorate inflammation and lipid accumulation in T2DM-induced MASLD via miR-155-regulated PPARγ signaling pathways沙蓬寡糖通过miR-155调控的PPARγ信号通路改善T2DM诱导的MASLD中的炎症和脂质积累DOI: 10.1016/j.jep.2026.122462
Patient education and counseling IF: 03.100Ahead of Print.No.11Exploring doctor-patient communication in glaucoma care: A systematic review探索青光眼诊疗中的医患沟通：一项系统性综述DOI: 10.1016/j.pec.2026.110333
Clinics IF: 02.400Ahead of Print.No.12Earlier onset of type 2 diabetes mellitus as a risk factor for Irvine-Gass syndrome早发2型糖尿病是Irvine-Gass综合征的风险因素DOI: 10.1016/j.clinsp.2026.101204
Comput Med Imaging Graph IF: 04.900Ahead of Print.No.13De-Seg: Advancing OCTA segmentation with multi-scale feature fusion and edge refinementDe-Seg：通过多尺度特征融合和边缘细化推进OCTA分割DOI: 10.1016/j.compmedimag.2026.102825
Comput Biol Chem IF: 03.100Ahead of Print.No.14Integrated expression profiling and structure-based drug discovery identify EGFR as a druggable target and Tripterygium wilfordii phytochemicals as potential therapeutics for autosomal dominant polycystic kidney disease整合表达谱分析与基于结构的药物发现确定EGFR为可成药靶点及雷公藤植物化学物作为常染色体显性多囊肾病的潜在治疗药物DOI: 10.1016/j.compbiolchem.2026.109477
J Biol Chem IF: 03.900Ahead of Print.No.15An m7G tRNA-derived fragment mediated thermogenic activation of brown adipose tissue through post-transcriptional repression of Uqcr10m7G tRNA衍生片段通过转录后抑制Uqcr10介导棕色脂肪组织的产热激活DOI: 10.1016/j.jbc.2026.113640
JHEP reports IF: 07.500Ahead of Print.No.16Spleen stiffness to rule out high-risk varices in advanced chronic liver disease: an individual patient data meta-analysis脾脏硬度用于排除晚期慢性肝病高危静脉曲张：一项个体患者数据荟萃分析DOI: 10.1016/j.jhepr.2026.102066
Current neuropharmacology IF: 05.300Ahead of Print.No.17From Clinical Manifestations to Neural Mechanisms: A Systematic Review of Neurobehavioral Consequences of Pregabalin Misuse and Abuse从临床表现到神经机制：普瑞巴林误用和滥用的神经行为后果的系统综述DOI: 10.2174/011570159X512277260929095531
Journal of Alzheimer's disease IF: 03.100Ahead of Print.No.18Cross-sectional associations of insulin resistance surrogate indices with cognitive disorders and cognitive performance in UK Biobank英国生物样本库中胰岛素抵抗替代指标与认知障碍及认知表现的横断面关联DOI: 10.1177/13872877261494125
Frontiers in nutrition IF: 05.100Volume 13, Issue No.19Correction: Enteral nutrition-related hyperglycemia in critical illness: cascade conceptual model and implications for precision nursing-a systematic review更正：危重症患者肠内营养相关高血糖：级联概念模型及精准护理的意义——一项系统综述DOI: 10.3389/fnut.2026.2000172
Science translational medicine IF: 14.600Volume 18, Issue 871No.20Metabolomic aging and mortality clocks based on ensemble learning identify systemic aging risk across the human life span in 18,476 individuals基于集成学习的代谢组衰老和死亡时钟在18,476名个体中识别人类全生命周期的系统性衰老风险DOI: 10.1126/scitranslmed.adz4815
PloS one IF: 02.600Volume 21, Issue 10No.21Association between the hemoglobin albumin lymphocyte and platelet score and chronic kidney disease: Insights from patient data and animal models血红蛋白、白蛋白、淋巴细胞和血小板评分与慢性肾脏病的关联：来自患者数据和动物模型的见解DOI: 10.1371/journal.pone.0353085
Sleep & breathing IF: 02.000Volume 30, Issue 6No.22Nonlinear age-related differences in clinical profiles of obstructive sleep apnea: a cross-sectional study of 1,508 Chinese patients阻塞性睡眠呼吸暂停临床特征的年龄相关非线性差异：一项针对1508名中国患者的横断面研究DOI: 10.1007/s11325-026-03836-3
Diabetologia IF: 10.200Ahead of Print.No.23Glucose controls metallothionein 1 gene expression in pancreatic islets via a mechanism involving cellular metabolism, granular zinc and the zinc transporter ZnT8 in rat and mouse葡萄糖通过涉及细胞代谢、颗粒锌和锌转运体ZnT8的机制调控大鼠和小鼠胰岛中金属硫蛋白1基因表达DOI: 10.1007/s00125-026-06900-5
Invest Ophthalmol Vis Sci IF: 04.700Volume 67, Issue 12No.24Targeting Endoplasmic Reticulum Stress With Exogenous GDNF Promotes Diabetic Corneal Epithelial and Neural Repair via PI3K/AKT Signaling外源性GDNF通过PI3K/AKT信号通路靶向内质网应激促进糖尿病角膜上皮和神经修复DOI: 10.1167/iovs.67.12.24
Transl Vis Sci Technol IF: 02.600Volume 15, Issue 10No.25FFA-SegGPT: A Two-Stage Cross-Modal AI System to Optimize the Clinical Workflow of Diabetic Retinopathy FFA InterpretationFFA-SegGPT：一种两阶段跨模态人工智能系统，优化糖尿病视网膜病变FFA解读的临床工作流程DOI: 10.1167/tvst.15.10.16
Autism : IF: 05.600Ahead of Print.No.26Disparities in Social Determinants of Health and Health Outcomes Among Autistic Individuals Without Intellectual Disability in Middle-to-Late Adulthood无智力障碍自闭症个体中晚年的健康社会决定因素与健康结局差异DOI: 10.1177/13623613261489847
Burns and trauma IF: 09.600Volume 14, Issue No.27Hydrogel microneedles for chronic wound microenvironment remodeling: from drug delivery to intelligent treatment用于慢性伤口微环境重塑的水凝胶微针：从药物递送到智能治疗DOI: 10.1093/burnst/tkag051
Int J Gen Med IF: 02.000Volume 19, Issue No.28Exploring the Relationship Between Femoral Neck Torsion Angle and Anteversion Angle Through Three-Dimensional Reconstruction in a Fixed Coordinate System通过固定坐标系三维重建探索股骨颈扭转角与前倾角的关系DOI: 10.2147/IJGM.S633691
Int J Gen Med IF: 02.000Volume 19, Issue No.29Recent Advances in the Diagnosis and Management of Gestational Diabetes Mellitus: A Narrative Review妊娠期糖尿病诊断与管理的最新进展：叙述性综述DOI: 10.2147/IJGM.S644149
Diabetes IF: 07.500Ahead of Print.No.30Skeletal Muscle DPT Ameliorates Obesity and Metabolic Dysfunction via the PERK/eIF2α/ATF4-GDF15 Axis骨骼肌DPT通过PERK/eIF2α/ATF4-GDF15轴改善肥胖和代谢功能障碍DOI: 10.2337/db26-0082
Adipocyte IF: 03.100Volume 15, Issue 1No.31The pro-obesity role of G3BP1 through altering adipogenic differentiation in mice via the PI3K/AKT pathwayG3BP1通过PI3K/AKT通路改变小鼠脂肪生成分化促进肥胖的作用DOI: 10.1080/21623945.2026.2743441
Current cancer drug targets IF: 03.500Ahead of Print.No.32Single-Cell Transcriptomics Identifies Fibroblast-Associated Transcriptional Patterns and Candidate Therapeutic Targets in the Comorbidity of Non-Small Cell Lung Cancer and Obesity单细胞转录组学识别非小细胞肺癌与肥胖共病中的成纤维细胞相关转录模式及候选治疗靶点DOI: 10.2174/0115680096497180260909094944
J Pediatr Gastroenterol Nutr IF: 02.600Ahead of Print.No.33The relationship between gut microbiota-friendly diet and the prevalence and severity of asthma in children肠道微生物群友好饮食与儿童哮喘患病率及严重程度的关系DOI: 10.1002/jpn3.70605
Advanced healthcare materials IF: 09.600Ahead of Print.No.34A Bioinspired Nanomedicine for Thermo-Catalytic Reprogramming of Obese Fat一种用于肥胖脂肪热催化重编程的仿生纳米药物DOI: 10.1002/adhm.71832
Frontiers in nutrition IF: 05.100Volume 13, Issue No.35Obesity and thyroid cancer: mechanisms and clinical implications肥胖与甲状腺癌：机制与临床意义DOI: 10.3389/fnut.2026.1887761
Food science & nutrition IF: 03.800Volume 14, Issue 10No.36Maternal Diglyceride Diet Attenuates Selected Metabolic Effects of Maternal High-Fat Feeding in Offspring via Energy Metabolism and Microbiota Modulation母体甘油二酯饮食通过能量代谢和微生物群调节减轻母体高脂喂养对子代的代谢影响DOI: 10.1002/fsn3.72427
Int J Endocrinol IF: 02.300Volume 2026, Issue No.37Link Between the Cardiometabolic Index and Stroke Risk Across Different Glucose Metabolic Status in Chinese Middle-Aged and Older Adults: A Longitudinal Cohort Study中国中老年人群心脏代谢指数与卒中风险的关联：不同糖代谢状态下的纵向队列研究DOI: 10.1155/ije/6169486
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.38Associations Between Multidimensional Obesity Indices and Diabetic Peripheral Neuropathy and Comparison of Their Discriminative Performance多维肥胖指标与糖尿病周围神经病变的关联及其判别性能比较DOI: 10.2147/DMSO.S634272
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.39Corneal endothelial changes in type 2 diabetes mellitus: a systematic review and meta-analysis with subgroup comparisons by diabetic retinopathy status and disease duration2型糖尿病的角膜内皮变化：按糖尿病视网膜病变状态和病程进行亚组比较的系统综述与荟萃分析DOI: 10.3389/fendo.2026.1982467
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.40Prevalence and risk factors of postmenopausal osteoporosis: a systematic review and meta-analysis based on multivariate logistic regression绝经后骨质疏松症的患病率及危险因素：基于多因素logistic回归的系统评价与meta分析DOI: 10.3389/fendo.2026.1950298
Frontiers in immunology IF: 05.900Volume 17, Issue No.41Diet, hormones, and breast cancer: biomarker-guided assessment of risk and prognosis饮食、激素与乳腺癌：生物标志物引导的风险与预后评估DOI: 10.3389/fimmu.2026.1946846
FCVM IF: 02.900Volume 13, Issue No.42Association between insulin resistance-related indices and cardiovascular disease in patients with atopic dermatitis: mutual validation using real-world and NHANES data胰岛素抵抗相关指数与特应性皮炎患者心血管疾病之间的关联：基于真实世界与NHANES数据的相互验证DOI: 10.3389/fcvm.2026.1903179
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.43Acute glycemic responses to meal-associated alcoholic beverages and ethanol in adults with type 2 diabetes: a systematic review2型糖尿病成人餐时饮用酒精饮料和乙醇的急性血糖反应：一项系统综述DOI: 10.3389/fendo.2026.1967515
Iran J Pharm Res IF: 01.800Volume 25, Issue 1No.44Yishen Xiaoke Formula Delays Renal Fibrosis in Rats with Diabetic Nephropathy by Suppressing the Transforming Growth Factor-Beta 1/Notch Signalling Pathway益肾消渴方通过抑制转化生长因子-β1/Notch信号通路延缓糖尿病肾病大鼠肾脏纤维化DOI: 10.5812/ijpr-171242
Frontiers in fungal biologyVolume 7, Issue No.45Case report: Fatal hematogenous gastrosplenic mucormycosis in an immunocompetent adult following sigmoid perforation, septic shock, and short-term stress glucocorticoids病例报告：免疫健全成人继发于乙状结肠穿孔、脓毒性休克及短期应激性糖皮质激素后的致死性血源性胃脾毛霉病DOI: 10.3389/ffunb.2026.1940494
Frontiers in immunology IF: 05.900Volume 17, Issue No.46X-linked hyper IgM syndrome with a novel CD40-ligand gene mutation suffered from infection of Talaromyces marneffeiX连锁高IgM综合征伴新型CD40配体基因突变患者感染马尔尼菲篮状菌DOI: 10.3389/fimmu.2026.1875082
Frontiers in medicine IF: 03.000Volume 13, Issue No.47Night-to-night sleep variability and all-cause and cardiovascular mortality: a prospective cohort study with a complementary in vitro circadian-disruption experiment夜间睡眠变异性与全因及心血管死亡：一项前瞻性队列研究及补充性体外昼夜节律紊乱实验DOI: 10.3389/fmed.2026.1917205
Frontiers in medicine IF: 03.000Volume 13, Issue No.48Development and validation of a novel metabolic-inflammatory health-related nomogram for predicting in-hospital mortality in older patients with type 2 diabetes mellitus combined with cardiovascular disease新型代谢-炎症健康相关列线图的开发与验证：用于预测老年2型糖尿病合并心血管疾病患者的院内死亡率DOI: 10.3389/fmed.2026.1914467
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.49CFTR variant-associated hereditary pancreatitis complicated by diabetes mellitus: a case report and literature reviewCFTR变异相关遗传性胰腺炎合并糖尿病：一例病例报告及文献综述DOI: 10.3389/fendo.2026.1907178
AME case reports IF: 00.700Volume 10, Issue No.50Classical Hodgkin lymphoma as a second malignancy in a patient with cervical squamous cell carcinoma following chemoradiotherapy: a case report宫颈鳞状细胞癌患者放化疗后发生经典霍奇金淋巴瘤作为第二恶性肿瘤：一例病例报告DOI: 10.21037/acr-2026-0174
Curēus IF: 01.300Volume 18, Issue 9No.51Association Between Left Atrial Volume Index (LAVI) and Glycemic Control (HbA1c) in Patients With Atrial Fibrillation and Type 2 Diabetes Mellitus左心房容积指数与血糖控制在心房颤动合并2型糖尿病患者中的关联DOI: 10.7759/cureus.116179
Frontiers in microbiology IF: 04.500Volume 17, Issue No.52A compartment-resolved framework for microbial sulfur-reactive sulfur signaling in diabetic cardiomyopathy: from gut metabolism to cardiac sulfur responses糖尿病心肌病中微生物硫-反应性硫信号传导的区室解析框架：从肠道代谢到心脏硫响应DOI: 10.3389/fmicb.2026.1966245
J Diabetes Metab Disord IF: 01.600Volume 25, Issue 2No.53The pharmacotherapy for pediatric obesity: insights and challenges from adult weight-loss medications儿童肥胖的药物治疗：来自成人减肥药物的启示与挑战DOI: 10.1007/s40200-026-02110-3
J Diabetes Metab Disord IF: 01.600Volume 25, Issue 2No.54Modulating inflammatory cytokines through acupuncture: Evidence from a systematic review通过针灸调节炎症细胞因子：来自系统综述的证据DOI: 10.1007/s40200-026-02098-w
Frontiers in medicine IF: 03.000Volume 13, Issue No.55Respiratory event duration reveals novel phenotypes beyond the apnea-hypopnea index in obstructive sleep apnea呼吸事件持续时间揭示阻塞性睡眠呼吸暂停中超越呼吸暂停低通气指数的新型表型DOI: 10.3389/fmed.2026.1960647
Frontiers in public health IF: 03.400Volume 14, Issue No.56The associations between dynapenic obesity and cognitive disorder in older hypertension patients: a multicenter cross-sectional study老年高血压患者肌少性肥胖与认知障碍的关联：一项多中心横断面研究DOI: 10.3389/fpubh.2026.1893791
Frontiers in nutrition IF: 05.100Volume 13, Issue No.57Multidimensional factors associated with childhood obesity severity in southern China: a cross-sectional study中国南方儿童肥胖严重程度相关的多维因素：一项横断面研究DOI: 10.3389/fnut.2026.1942160
Acta diabetologica IF: 02.900Ahead of Print.No.58Aldosterone–mineralocorticoid receptor signaling and residual cardiorenal risk in type 2 diabetes醛固酮-盐皮质激素受体信号与2型糖尿病残余心肾风险DOI: 10.1007/s00592-026-02811-4
J Transl Med IF: 07.500Volume 24, Issue 1No.59NRF2 activation attenuates obesity-induced adipose inflammation by suppressing STING signaling, with depot-specific regulationNRF2激活通过抑制STING信号减轻肥胖诱导的脂肪炎症，并具有脂肪库特异性调控DOI: 10.1186/s12967-026-08887-4
J Cell Mol Med IF: 04.200Volume 30, Issue 20No.60Application of Panax notoginseng Saponins in Skin Wound Repair: Mechanisms and Research Progress三七总皂苷在皮肤创面修复中的应用：机制与研究进展DOI: 10.1111/jcmm.71381
CCI IF: 01.900Ahead of Print.No.61The Impact of Dual Antiplatelet Therapy on Bleeding and Thrombotic Risks in Diabetic Patients Following Coronary Stent Implantation: A Prospective Study双联抗血小板治疗对冠状动脉支架植入术后糖尿病患者出血与血栓风险的影响：一项前瞻性研究DOI: 10.1002/ccd.70940
European journal of pain IF: 03.400Volume 30, Issue 9No.62Veratramine Alleviates Neuropathic Pain in Male Rats With Chronic Constriction Injury and Inhibits the PI3K/Akt Pathway藜芦胺缓解慢性压迫性损伤雄性大鼠的神经病理性疼痛并抑制PI3K/Akt通路DOI: 10.1002/ejp.70383
J Ocul Pharmacol Ther IF: 02.100Ahead of Print.No.63Ocular Distribution and Metabolite Profiling of Vorolanib in Rats and Its In Vitro Metabolism Using Human Recombinant Enzymes伏罗尼布在大鼠眼部分布及代谢物谱及其利用人重组酶的体外代谢研究DOI: 10.1177/10807683261496831
Biomed Environ Sci IF: 04.100Volume 39, Issue 9No.64Associations of the Triglyceride-glucose Index and Its Obesity-related Indices with Microvascular Complications among Individuals with Type 2 Diabetes: A Prospective Cohort Study甘油三酯-葡萄糖指数及其肥胖相关指数与2型糖尿病患者微血管并发症的关联：一项前瞻性队列研究DOI: 10.3967/bes2026.098
Biomed Environ Sci IF: 04.100Volume 39, Issue 9No.65Dietary Live Microbe Intake and Sarcopenia in Shanghai上海地区膳食活性微生物摄入与肌肉减少症的关联研究DOI: 10.3967/bes2026.095
Biomed Environ Sci IF: 04.100Volume 39, Issue 9No.66A Nationwide Cross-Sectional Study of Chronic Urticaria in Chinese Adults with Cardiometabolic Diseases: Epidemiology, Risk Factors, and Effect on Disease Management中国成人慢性荨麻疹合并心血管代谢疾病的全国横断面研究：流行病学、危险因素及对疾病管理的影响DOI: 10.3967/bes2026.084
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.67Transition-Specific Associations of Cardiometabolic Biomarker Burden With Cardio-Renal-Metabolic Multimorbidity Progression: A Multistate Cohort Study心血管代谢生物标志物负担与心血管-肾脏-代谢多病进展的转变特异性关联：一项多状态队列研究DOI: 10.1111/dom.71427
Advanced healthcare materials IF: 09.600Ahead of Print.No.68Immune‑Friendly Skin Interface Remodeling: Chiral Hydrogels for Diabetic Non-Healing Wound Therapy免疫友好型皮肤界面重塑：手性水凝胶用于糖尿病非愈合性创面治疗DOI: 10.1002/adhm.71842
Nature communications IF: 15.700Volume 17, Issue 1No.69PKM2 AP: a micropeptide inhibits vascular calcification via molecular glue-mediated ubiquitination of PKM2PKM2 AP：一种通过分子胶介导的PKM2泛素化抑制血管钙化的微肽DOI: 10.1038/s41467-026-77693-9
Signal Transduct Target Ther IF: 52.700Volume 11, Issue 1No.70Rhein-induced free fatty acid generation cooperates with silver ions for biofilm-infected diabetic wound healing大黄酸诱导游离脂肪酸生成与银离子协同促进生物膜感染的糖尿病伤口愈合DOI: 10.1038/s41392-026-02869-0
Clinical pharmacokinetics IF: 04.000Ahead of Print.No.71Efsubaglutide Alfa: A Comprehensive Pharmacological Review依苏帕格鲁肽α：综合药理学综述DOI: 10.1007/s40262-026-01713-6
Journal of molecular histology IF: 02.200Volume 57, Issue 6No.72Liraglutide ameliorates obese type 2 diabetes by regulating macrophage cholesterol metabolism and H3K27ac modification to promote M2 polarization and adipocyte thermogenic activation利拉鲁肽通过调控巨噬细胞胆固醇代谢和H3K27ac修饰促进M2极化和脂肪细胞产热激活改善肥胖型2型糖尿病DOI: 10.1007/s10735-026-10993-y
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Pain medicine case reportsVolume 10, Issue 7No.04Peripheral Nerve Stimulator Implant for Superior Cluneal Neuralgia in Patients with Peripheral Neuropathy: A Case Series周围神经刺激器植入治疗周围神经病患者的上臀神经痛：病例系列https://pubmed.ncbi.nlm.nih.gov/42874086
J Biol Chem IF: 03.900Ahead of Print.No.05ERK-mediated phosphorylation modulates the autolytic processing of the cysteine protease CAPN3ERK介导的磷酸化调节半胱氨酸蛋白酶CAPN3的自溶加工DOI: 10.1016/j.jbc.2026.113638
Biochem Biophys Res Commun IF: 02.200Ahead of Print.No.06Efonidipine inhibiting CYP4A attenuates palmitate-induced hepatocyte lipotoxicity依福地平抑制CYP4A减轻棕榈酸诱导的肝细胞脂毒性DOI: 10.1016/j.bbrc.2026.154723
Res Social Adm Pharm IF: 02.800Ahead of Print.No.07Pharmacists and Ramadan: From education to practice - A mixed methods systematic review药师与斋月：从教育到实践——一项混合方法系统综述DOI: 10.1016/j.sapharm.2026.10.150
Transplantation proceedings IF: 00.800Ahead of Print.No.08Profound Tacrolimus-Induced Catatonic Encephalopathy in a Kidney Transplant Recipient With Mitochondrial Myopathy: A Cautionary Case of Reversible Neurotoxicity线粒体肌病肾移植受者中他克莫司诱导的严重紧张症性脑病：一例可逆性神经毒性的警示病例DOI: 10.1016/j.transproceed.2026.09.022
Diabetic medicine IF: 03.400Ahead of Print.No.09The DePICtion study: Implementing a diabetes classification tool in UK primary care-A qualitative study with primary care staff and patientsDePICtion研究：在英国初级保健中实施糖尿病分类工具——一项针对初级保健工作人员和患者的定性研究DOI: 10.1111/dme.70493
J Atheroscler Thromb IF: 02.800Ahead of Print.No.10Associations of Albuminuria and eGFR with Stiffness Parameter β in Type 2 Diabetes2型糖尿病患者白蛋白尿与估算肾小球滤过率同僵硬度参数β的关联DOI: 10.5551/jat.66371
Endocrine journal IF: 02.100Ahead of Print.No.11Metreleptin improves glucose metabolism and hepatic steatosis in a patient with Werner syndrome and partial lipodystrophy: a case report with review of literature美曲普汀改善Werner综合征合并部分性脂肪萎缩患者的糖代谢和肝脂肪变性：一例病例报告及文献综述DOI: 10.1507/endocrj.EJ26-0235
Diabetic medicine IF: 03.400Ahead of Print.No.12Capability, opportunity and motivation to support adults with type 1 diabetes experiencing fear of hypoglycaemia: A survey of Australian diabetes healthcare professionals支持经历低血糖恐惧的成人1型糖尿病患者的能力、机会和动机：一项针对澳大利亚糖尿病医疗专业人员的调查DOI: 10.1111/dme.70496
Internal medicine IF: 01.100Ahead of Print.No.13Ampullary Neuroendocrine Carcinoma Presenting with Clinically Confirmed Endogenous Hyperinsulinemic Hypoglycemia以临床确诊的内源性高胰岛素性低血糖为表现的壶腹部神经内分泌癌DOI: 10.2169/internalmedicine.7605-26
Diabetic medicine IF: 03.400Ahead of Print.No.14The impact of frailty on glycaemic control in older adults with type 1 diabetes mellitus: An observational study衰弱对老年1型糖尿病患者血糖控制的影响：一项观察性研究DOI: 10.1111/dme.70498
Diabetic medicine IF: 03.400Ahead of Print.No.15Estimating the long-term cost-effectiveness of a free online Diabetes Self-Management Education and Support service in England: Healthy living for people with type 2 diabetes, using a matched cohort study design基于匹配队列研究设计评估英格兰免费在线糖尿病自我管理教育与支持服务的长期成本效果：针对2型糖尿病患者的健康生活项目DOI: 10.1111/dme.70490
BMJ case reports IF: 00.500Volume 19, Issue 10No.16Diabetic ketoacidosis in a patient with renal cell carcinoma on immune checkpoint inhibitor接受免疫检查点抑制剂治疗的肾细胞癌患者发生糖尿病酮症酸中毒DOI: 10.1136/bcr-2025-268141
Enfermeri?a cli?nicaAhead of Print.No.17The role of nurses in shared decision-making in primary care: Qualitative study护士在初级保健共享决策中的作用：定性研究DOI: 10.1016/j.enfcle.2026.502562
Journal of Advanced Research IF: 13.000Ahead of Print.No.18Association between dental pulp necroptosis-related signaling and elodont incisor growth retardation in hyperglycemic rats高血糖大鼠牙髓坏死性凋亡相关信号与持续生长切牙生长迟缓的关联DOI: 10.1016/j.jare.2026.10.027
Appetite IF: 03.800Ahead of Print.No.19Neuroimaging Insights into the Effects of Non-Nutritive Sweeteners on Appetite Regulation: A Systematic Review非营养性甜味剂对食欲调节影响的神经影像学见解：一项系统综述DOI: 10.1016/j.appet.2026.108803
Brain, behavior, and immunity IF: 07.600Ahead of Print.No.20Early post-sepsis innate behavioral changes in aged mice occur independently of detectable neuroinflammation老年小鼠脓毒症后早期先天行为改变独立于可检测的神经炎症DOI: 10.1016/j.bbi.2026.107062
Toxicol Appl Pharmacol IF: 03.400Ahead of Print.No.21High Normal dietary casein attenuates bisphenol A-induced multiorgan toxicity in rats: Preservation of renal integrity, glucose homeostasis, and immune surveillance via modulation of oxidative stress, inflammation, and apoptosis高正常膳食酪蛋白减轻双酚A诱导的大鼠多器官毒性：通过调节氧化应激、炎症和凋亡保护肾脏完整性、葡萄糖稳态和免疫监视DOI: 10.1016/j.taap.2026.118085
Annals of Vascular Surgery IF: 01.600Ahead of Print.No.22"Not so minor" - Digital Amputation as a precursor to Major Amputation and Mortality in an Irish tertiary vascular centre“并非小问题”——趾截肢作为爱尔兰三级血管中心大截肢和死亡的前兆DOI: 10.1016/j.avsg.2026.09.058
Annals of Vascular Surgery IF: 01.600Ahead of Print.No.23THE CLINICAL PROFILE OF RUPTURE: A 19-YEAR CASE-CONTROL STUDY OF ABDOMINAL AORTIC ANEURYSMS破裂的临床特征：一项为期19年的腹主动脉瘤病例对照研究DOI: 10.1016/j.avsg.2026.09.070
Complement Ther Med IF: 03.500Ahead of Print.No.24Pilot, Feasibility, and Acceptability Evaluation of a Mindfulness-Based Intervention with Diabetes Education in Adolescents with Type 1 Diabetes基于正念的干预联合糖尿病教育在1型糖尿病青少年中的试点、可行性和可接受性评估DOI: 10.1016/j.ctim.2026.103451
Diabetes Res Clin Pract IF: 07.400Ahead of Print.No.25Effects of diagnostic thresholds for gestational diabetes on perinatal mental health: Data from the GEMS randomised clinical trial妊娠糖尿病诊断阈值对围产期心理健康的影响：来自GEMS随机临床试验的数据DOI: 10.1016/j.diabres.2026.113590
Photodiagnosis Photodyn Ther IF: 02.600Ahead of Print.No.26Epivascular Glia and Macular Pigment Changes after Faricimab or Aflibercept during the Loading Phase in Diabetic Macular Edema: A Prospective Non-randomized Pilot Study糖尿病性黄斑水肿负荷期使用Faricimab或Aflibercept后血管周围胶质细胞和黃斑色素变化：一项前瞻性非随机初步研究DOI: 10.1016/j.pdpdt.2026.105687
Cornea IF: 02.100Ahead of Print.No.27The Effects of Age on the Presence of Atypical Corneal Nerve Formations年龄对非典型角膜神经结构存在的影响DOI: 10.1097/ICO.0000000000004341
Journal of tissue viability IF: 02.800Ahead of Print.No.28Findings on the efficacy of sonic debridement in chronic wound management - a case series声波清创在慢性伤口管理中的有效性研究——病例系列DOI: 10.1016/j.jtv.2026.101064
Rev Argent Microbiol IF: 02.100Ahead of Print.No.29Antimicrobial resistance and antibiotic therapy in patients with urinary tract infections and asymptomatic bacteriuria: A Peruvian perspective尿路感染与无症状性菌尿患者的抗菌药物耐药性及抗生素治疗：秘鲁视角DOI: 10.1016/j.ram.2026.100760
Clin Neurol Neurosurg IF: 01.600Ahead of Print.No.30Differentiating pituitary metastasis from hypophysitis: A two-center study using conventional MRI and clinical features鉴别垂体转移瘤与垂体炎：基于常规MRI和临床特征的双中心研究DOI: 10.1016/j.clineuro.2026.109662
Diabetes & metabolic syndrome IF: 03.400Ahead of Print.No.31Evaluation of a local healthy moderate carbohydrate (LHMC) diet and structured exercise for diabetes remission in early type 2 diabetes mellitus: A nutrition intervention study from India评估本地健康中等碳水化合物饮食与结构化运动对早期2型糖尿病缓解的作用：一项来自印度的营养干预研究DOI: 10.1016/j.dsx.2026.103487
J Pharmacol Exp Ther IF: 03.800Ahead of Print.No.32Sirtuin 1-microRNA regulatory networks in liver diseases: Mechanistic convergence, cellular senescence, and translational implications肝脏疾病中的Sirtuin 1-微小RNA调控网络：机制汇聚、细胞衰老及转化意义DOI: 10.1016/j.jpet.2026.105031
Injury IF: 02.000Ahead of Print.No.33Association of neighborhood social vulnerability with reoperation after operative treatment of proximal humerus fractures社区社会脆弱性与肱骨近端骨折手术治疗后再手术的关联DOI: 10.1016/j.injury.2026.113769
J Plast Reconstr Aesthet Surg IF: 02.400Ahead of Print.No.34GLP-1 receptor agonist use and postoperative complications after body contouring surgery following massive weight loss减重手术后身体塑形手术中GLP-1受体激动剂使用与术后并发症的关系DOI: 10.1016/j.bjps.2026.09.040
Clin Transl Sci IF: 02.800Volume 19, Issue 10No.35Analysis of Virologic and Clinical Predictors for Hospitalization, Supported by Machine Learning, in a Phase 3 Molnupiravir COVID-19 Treatment Trial在3期molnupiravir COVID-19治疗试验中，通过机器学习支持分析住院的病毒学和临床预测因素DOI: 10.1111/cts.70720
Journal of chromatography IF: 02.800Ahead of Print.No.36Development and validation of qualitative methods for the detection of GLP-1 receptor agonists in serum and dried blood spots by LC-HRMS/MS for doping control purposes用于兴奋剂检测的血清和干血斑中GLP-1受体激动剂的LC-HRMS/MS定性方法的开发与验证DOI: 10.1016/j.jchromb.2026.125326
J Matern Fetal Neonatal Med IF: 01.600Volume 39, Issue 1No.37Characterizing vaginal misoprostol induction in individuals with and without severe obesity严重肥胖与非严重肥胖个体阴道米索前列醇引产的特征分析DOI: 10.1080/14767058.2026.2744004
Surg Obes Relat Dis IF: 03.800Ahead of Print.No.38Clinical outcomes in solid organ transplant recipients undergoing Roux-en-Y gastric bypass surgery: a propensity score-matched study实体器官移植受者接受Roux-en-Y胃旁路手术的临床结局：一项倾向性评分匹配研究DOI: 10.1016/j.soard.2026.09.015
Internal medicine IF: 01.100Ahead of Print.No.39Changes in Gait Speed During a 12-Month Multidisciplinary Obesity Management Program Including Semaglutide: A Real-World Observational Study in Japanese Adults With Musculoskeletal Disorders包含司美格鲁肽的12个月多学科肥胖管理项目期间步速变化：一项针对患有肌肉骨骼疾病的日本成人的真实世界观察性研究DOI: 10.2169/internalmedicine.8145-26
J Obes Metab Syndr IF: 07.900Ahead of Print.No.40Perspectives on Community-Based Pediatric Obesity Prevention and Management Programs in South Korea: A Qualitative Interview Study of School and Local Public Health Center Providers韩国社区儿童肥胖预防与管理项目的视角：对学校和地方公共卫生中心提供者的定性访谈研究DOI: 10.7570/jomes25099
Journal of neuroendocrinology IF: 04.100Volume 38, Issue 10No.41Changes in leptin and melanocortin peptides in cerebrospinal fluid after diet versus bariatric surgery饮食与减重手术后脑脊液中瘦素和黑皮质素肽的变化DOI: 10.1111/jne.70292
Journal of applied gerontology : IF: 02.000Ahead of Print.No.42Beyond BMI: The Role of Abdominal Obesity in Hypertension Risk Among Adults Aged 45 Years and Older in India超越体重指数：腹型肥胖在印度45岁及以上成年人高血压风险中的作用DOI: 10.1177/07334648261497261
Canadian journal of diabetes IF: 02.600Ahead of Print.No.43The Causal Role of Adiponectin in Type 2 Diabetes across Ages and Sexes - An Observational and Mendelian Randomization Study脂联素在2型糖尿病中的因果作用：跨年龄和性别的观察性与孟德尔随机化研究DOI: 10.1016/j.jcjd.2026.09.010
Fish & shellfish immunology IF: 03.900Ahead of Print.No.44A c-Jun N-terminal kinase (JNK) homolog from Macrobrachium rosenbergii participates in immune defense against Aeromonas hydrophila罗氏沼虾c-Jun N末端激酶（JNK）同源物参与抗嗜水气单胞菌的免疫防御DOI: 10.1016/j.fsi.2026.111771
Diabetes Res Clin Pract IF: 07.400Ahead of Print.No.45Capturing human-machine interplay in automated insulin delivery systems through day-to-day variability of the automated correction index (ACI-V%)通过自动校正指数日间变异性（ACI-V%）捕捉自动胰岛素输送系统中的人机交互DOI: 10.1016/j.diabres.2026.113613
Reproductive toxicology IF: 02.800Ahead of Print.No.46Glycerol supplementation attenuates testicular inflammation and miRNA dysregulation in obese rats甘油补充减轻肥胖大鼠的睾丸炎症和微小RNA失调DOI: 10.1016/j.reprotox.2026.109380
Archives of medical research IF: 03.400Ahead of Print.No.47Sex-Specific Neurobehavioral Programming in Offspring by a Maternal High-Fat, Plant-Based Diet: A Central Role of the Hippocampus母体高脂植物性饮食对子代神经行为编程的性别特异性影响：海马的核心作用DOI: 10.1016/j.arcmed.2026.103530
Heart, Lung and Circulation IF: 02.200Ahead of Print.No.48Lipoprotein(a) Reporting by Australian Chemical Pathology Laboratories澳大利亚化学病理实验室的脂蛋白(a)检测报告实践DOI: 10.1016/j.hlc.2026.05.016
The Lancet Psychiatry IF: 24.800Volume 13, Issue 11, Page 905-974, e14No.49Change in HbA1c and weight after initiation of antipsychotic treatment in people with severe mental illness in England: an individual-level interrupted time-series analysis英格兰严重精神疾病患者启动抗精神病药物治疗后糖化血红蛋白和体重的变化：个体水平中断时间序列分析DOI: 10.1016/S2215-0366(26)00274-9
The Lancet Psychiatry IF: 24.800Volume 13, Issue 11, Page 905-974, e14No.50GLP-1 receptor agonist initiation and risk of psychiatric hospitalisation and emergency department presentation in adults with schizophrenia and type 2 diabetes in the USA: an observational cohort study using electronic health records dataGLP-1受体激动剂起始治疗与精神分裂症合并2型糖尿病成人患者精神科住院及急诊就诊风险：基于电子健康记录数据的观察性队列研究DOI: 10.1016/S2215-0366(26)00276-2
The Lancet Psychiatry IF: 24.800Volume 13, Issue 11, Page 905-974, e14No.51Preventing predictable harm in severe mental illness预防严重精神疾病中可预测的伤害DOI: 10.1016/S2215-0366(26)00301-9
EJPC IF: 07.500Ahead of Print.No.52Outcomes in patients with diabetes, atherosclerotic cardiovascular disease, and heart failure treated with tirzepatide or dulaglutide: SURPASS-CVOT analysis合并糖尿病、动脉粥样硬化性心血管疾病和心力衰竭患者接受替尔泊肽或度拉糖肽治疗的结果：SURPASS-CVOT分析DOI: 10.1093/eurjpc/zwag452
Cardiovascular Diabetology IF: 10.600Ahead of Print.No.53Event-anchored piecewise trajectories of the triglyceride-glucose index before and after incident cardiovascular disease: a propensity score-matched longitudinal study from the English Longitudinal Study of Ageing甘油三酯-葡萄糖指数在心血管疾病发病前后的以事件为锚点的分段轨迹：来自英国老龄化纵向研究的倾向评分匹配纵向研究DOI: 10.1186/s12933-026-03387-7
JAMA surgery IF: 14.900Ahead of Print.No.54Bariatric Surgery Is Preventive Medicine减重手术是预防医学DOI: 10.1001/jamasurg.2026.4778
NEJM IF: 78.500Ahead of Print.No.55Continuous Glucose Monitoring in Non–Insulin-Treated Type 2 Diabetes非胰岛素治疗的2型糖尿病中的持续葡萄糖监测DOI: 10.1056/NEJMoa2608571
NEJM IF: 78.500Volume 395, Issue 15No.56Adult Attention Deficit–Hyperactivity Disorder成人注意缺陷多动障碍DOI: 10.1056/NEJMcp2516040
NEJM IF: 78.500Volume 395, Issue 15No.57Setmelanotide for the Treatment of Acquired Hypothalamic ObesitySetmelanotide用于治疗获得性下丘脑性肥胖DOI: 10.1056/NEJMc2610994
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.58Identifying a high-risk CKM syndrome phenotype: association of albuminuria with subclinical hemodynamic alterations via portable noninvasive cardiometer识别高风险心血管-肾脏-代谢综合征表型：白蛋白尿与便携式无创心排量监测仪检测的亚临床血流动力学改变的关联DOI: 10.3389/fendo.2026.1966139
Journal of opioid managementVolume 22, Issue 5No.59Comparison of long-term outcomes between opioid-free and opioid-based anesthesia in head and neck cancer surgeries: A pilot study头颈癌手术中无阿片类麻醉与阿片类麻醉长期结局的比较：一项初步研究DOI: 10.5055/jom.0996
JAMA psychiatry IF: 17.100Ahead of Print.No.60Patient-Reported Changes in Alcohol Use Following Glucagon-Like Peptide-1 Receptor Agonist Initiation胰高血糖素样肽-1受体激动剂启用后患者报告的酒精使用变化DOI: 10.1001/jamapsychiatry.2026.3242
Aesthetic surgery journal / IF: 03.900Ahead of Print.No.61Glucagon-Like Peptide-1 Receptor Agonist-Associated Facial Changes: A Comprehensive Review of Pathophysiology, Clinical Manifestations, Risk Factors, Prevention, and Management胰高血糖素样肽-1受体激动剂相关的面部变化：病理生理学、临床表现、危险因素、预防和管理的综合综述DOI: 10.1093/asj/sjag230
PRiMERVolume 10, Issue No.62Glycemic Outcomes Associated With GLP-1 Receptor Agonist Shortages in Type 2 Diabetes2型糖尿病患者中GLP-1受体激动剂短缺相关的血糖结局DOI: 10.22454/PRiMER.2026.826203
Med J Islam Repub IranVolume 40, Issue No.63Mechanisms of Vestibular System Damage in Diabetes Mellitus: Implications for Benign Paroxysmal Positional Vertigo Pathogenesis and Recurrence糖尿病中前庭系统损伤的机制：对良性阵发性位置性眩晕发病机制和复发的影响DOI: 10.47176/mjiri.40.75
Plant signaling & behavior IF: 03.600Volume 21, Issue 1No.64γ-aminobutyric acid is associated with calcium, reactive oxygen species, and nitric oxide responses and enhanced cadmium tolerance in Salvadora persicaγ-氨基丁酸与钙、活性氧和一氧化氮响应相关并增强Salvadora persica的镉耐受性DOI: 10.1080/15592324.2026.2748062
AME case reports IF: 00.700Volume 10, Issue No.65Thyroid storm revealing suspected evolving autoimmune polyglandular syndrome type 2 with steroid-limited assessment of autoimmune adrenal insufficiency: a case report甲状腺危象揭示疑似进展性自身免疫性多腺体综合征2型伴类固醇限制性自身免疫性肾上腺功能不全评估：一例病例报告DOI: 10.21037/acr-2026-0181
Clinical science IF: 07.700Ahead of Print.No.66Deletion of Nephrocystin-4 Exacerbates Kidney and Cardiac Function in Mice Cardiorenal Syndrome Model via the Interaction with Itch E3 ligaseNephrocystin-4缺失通过与其Itch E3连接酶的相互作用加重小鼠心肾综合征模型中的肾脏和心脏功能DOI: 10.1042/CS20262448
J Mol Neurosci IF: 02.700Volume 76, Issue 4No.67"Morphological, Functional, and Molecular Progression of Blood-Brain Barrier Dysfunction in Alzheimer's Disease"阿尔茨海默病中血脑屏障功能障碍的形态学、功能与分子进展DOI: 10.1007/s12031-026-02610-0
Current pharmaceutical design IF: 02.800Ahead of Print.No.68Emerging Therapeutic Strategies for Graves' Disease: Current Advances and Future PerspectivesGraves病的新兴治疗策略：当前进展与未来展望DOI: 10.2174/0113816128537581261007065942
Brain : IF: 11.700Ahead of Print.No.69Biallelic variants in PIKFYVE cause a hypomyelinating leukodystrophy with endolysosomal dysfunctionPIKFYVE双等位基因变异导致伴内溶酶体功能障碍的低髓鞘性脑白质营养不良DOI: 10.1093/brain/awag355
ACS Pharmacol Transl Sci IF: 03.700Volume 9, Issue 10No.70A Human Glucoregulatory Model for the Rational Design and Evaluation of Diabetes Therapeutics用于糖尿病治疗药物理性设计与评估的人类血糖调控模型DOI: 10.1021/acsptsci.6c00356
ACS Pharmacol Transl Sci IF: 03.700Volume 9, Issue 10No.71Hepatic Overexpression of a Novel Soluble Endogenous Transforming Growth Factor β Type II Receptor-Immunoglobulin G1 Fc Fusion Protein (TβRII-SE/Fc) Attenuates Early Stage Metabolic Dysfunction-Associated Steatotic Liver Disease in Rats肝脏过表达新型可溶性内源性转化生长因子β II型受体-免疫球蛋白G1 Fc融合蛋白（TβRII-SE/Fc）减轻大鼠早期代谢功能障碍相关脂肪性肝病DOI: 10.1021/acsptsci.6c00410
ACS Pharmacol Transl Sci IF: 03.700Volume 9, Issue 10No.72Diabetes-Associated Cognitive Dysfunction: Pathophysiology, Molecular Mechanisms, and Emerging Therapeutic Strategies糖尿病相关认知功能障碍：病理生理学、分子机制与新兴治疗策略DOI: 10.1021/acsptsci.6c00440
Clin Exp Dermatol IF: 02.800Ahead of Print.No.73Prescribed insulin use in type II diabetes mellitus and skin cancer risk: A systematic review 32型糖尿病中处方胰岛素使用与皮肤癌风险：一项系统综述3DOI: 10.1093/ced/llag444
Cancer reports IF: 01.900Volume 9, Issue 10No.74Periprocedural Wound Complication Risks in Cancer Pain Patients Following Targeted Cancer Therapy: A Retrospective Analysis癌症疼痛患者接受靶向癌症治疗后的围手术期伤口并发症风险：一项回顾性分析DOI: 10.1002/cnr2.70664
J Clin Invest IF: 13.600Ahead of Print.No.75Manganese availability determines hepatic insulin sensitivity by enhancing Akt activity锰的可利用性通过增强Akt活性决定肝脏胰岛素敏感性DOI: 10.1172/JCI200951
J Clin Invest IF: 13.600Ahead of Print.No.76SGLT1/2 inhibitor sotagliflozin, but not SGLT2-selective inhibitor empagliflozin, attenuates platelet activation and thrombosisSGLT1/2抑制剂索格列净而非SGLT2选择性抑制剂恩格列净可减弱血小板活化和血栓形成DOI: 10.1172/JCI201899
Salud pública de México IF: 03.100Volume 68, Issue 5 (sept-oct)No.77[Not Available]2025年Ensanut视觉健康模块的方法学设计与范围DOI: 10.21149/18641
JIC IF: 01.400Ahead of Print.No.78Chronic total occlusion percutaneous coronary interventions in dialysis patients透析患者的慢性完全闭塞经皮冠状动脉介入治疗DOI: 10.25270/jic/26.00260
Diabetes care IF: 16.600Ahead of Print.No.79Erratum. Sodium-Glucose Cotransporter 2 Inhibitor Use and Risk of Liver-Related Events in Patients With Type 2 Diabetes: A Meta-analysis of Observational Cohort Studies. Diabetes Care 2025;48:1042-1052勘误。钠-葡萄糖协同转运蛋白2抑制剂使用与2型糖尿病患者肝脏相关事件风险：观察性队列研究的Meta分析。Diabetes Care 2025;48:1042-1052DOI: 10.2337/dc27-er01
Wounds IF: 01.100Volume 38, Issue 9No.80Prospective evaluation of the clinical effectiveness of an innovative catalytic wound care technology创新催化伤口护理技术临床有效性的前瞻性评估DOI: 10.25270/wnds/25122
PLOS pathogens IF: 04.900Ahead of Print.No.81Intranasal HSV‑1 infection drives region‑specific interferon‑dominant microglial remodeling鼻内HSV-1感染驱动区域特异性干扰素主导的小胶质细胞重塑DOI: 10.1371/journal.ppat.1014684
PloS one IF: 02.600Volume 21, Issue 10No.82Subnational spatial co-distribution of tuberculosis and diabetes mellitus across Ghana's 16 regions following administrative reorganisation: An ecological analysis行政重组后加纳16个地区结核病与糖尿病的次国家级空间共分布：一项生态学分析DOI: 10.1371/journal.pone.0354405
PloS one IF: 02.600Volume 21, Issue 10No.83Low diet quality increases the genetic risk of high blood cholesterol levels in Asian Indian adults [CURES - 165]低饮食质量增加亚洲印度成年人高血胆固醇水平的遗传风险 [CURES - 165]DOI: 10.1371/journal.pone.0357182
Gerontology : IF: 03.000Ahead of Print.No.84Local RAGE Inhibition Attenuates Early Diabetic Retinal Pathology in Streptozotocin-Induced Rats局部RAGE抑制减轻链脲佐菌素诱导大鼠的早期糖尿病视网膜病变DOI: 10.1159/ger/acxag008
J Biomol Struct Dyn IF: 02.400Ahead of Print.No.85Structure-dynamics analysis of insulin receptor modulation by plant-derived ligands suggests a potential regulatory role for Asn711植物来源配体调控胰岛素受体的结构动力学分析提示Asn711的潜在调控作用DOI: 10.1080/07391102.2026.2741934
Diabetes care IF: 16.600Ahead of Print.No.86Contemporary Sex-Specific Mortality Risk in Type 1 Diabetes During the Era of Advanced Therapeutic Care当代先进治疗护理时代1型糖尿病的性别特异性死亡风险DOI: 10.2337/dc26-1472
Journal of periodontology IF: 03.800Ahead of Print.No.87Association between xerostomia and peri-implant health: A retrospective cohort study口干症与种植体周围健康之间的关联：一项回顾性队列研究DOI: 10.1002/jper.70192
GeroScience IF: 05.400Ahead of Print.No.88Plasma biomarkers of neurodegeneration and physical performance in older adults老年人神经退行性变的血浆生物标志物与身体表现DOI: 10.1007/s11357-026-02570-8
Clin Rev Allergy Immunol IF: 11.300Volume 69, Issue 1No.89Single-cell Transcriptomics in Autoimmune Diseases: Mechanistic Insights, Cross-disease Convergence, and Translational Challenges in Rheumatoid Arthritis, Systemic Lupus Erythematosus, Type 1 Diabetes, and Multiple Sclerosis自身免疫性疾病中的单细胞转录组学：类风湿关节炎、系统性红斑狼疮、1型糖尿病和多发性硬化中的机制见解、跨疾病趋同及转化挑战DOI: 10.1007/s12016-026-09211-0
J Cardiovasc Surg (Torino) IF: 01.500Ahead of Print.No.90Bailout stenting strategy in complex femoropopliteal lesions: mid-term outcomes with drug-eluting versus bare-metal stents复杂股腘动脉病变的补救性支架策略：药物洗脱支架与裸金属支架的中期结局DOI: 10.23736/S0021-9509.26.13592-7
JACC: Cardiovascular Imaging IF: 15.200Ahead of Print.No.91Bending the Curve: Revealing Population Risk With Quantitative Atherosclerotic Plaque扭转曲线：利用定量动脉粥样硬化斑块揭示人群风险DOI: 10.1016/j.jcmg.2026.09.002
Invest Ophthalmol Vis Sci IF: 04.700Volume 67, Issue 12No.92Neuroprotective and Anti-Inflammatory Effects of SOCS1 Mimetic Peptides in Mouse Diabetic RetinopathySOCS1模拟肽在小鼠糖尿病视网膜病变中的神经保护与抗炎作用DOI: 10.1167/iovs.67.12.21
J Diabetes Sci Technol IF: 03.700Ahead of Print.No.93Redistributing Insulin Pumps for Patients Facing Access Barriers为面临获取障碍的患者重新分配胰岛素泵DOI: 10.1177/19322968261493576
J Diabetes Sci Technol IF: 03.700Ahead of Print.No.94Effectiveness of Continuous Glucose Monitoring in Non-Intensively Managed Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials持续葡萄糖监测在非强化管理的2型糖尿病中的有效性：随机对照试验的系统评价与荟萃分析DOI: 10.1177/19322968261489265
J Diabetes Sci Technol IF: 03.700Ahead of Print.No.95From Clinician-Based Risk Score to Diabetes Complications: Validating the Glycemia Risk Index with the Virtual Diabetes Control and Complications Trial Continuous Glucose Monitoring Data从临床医生风险评分到糖尿病并发症：利用虚拟糖尿病控制与并发症试验的连续葡萄糖监测数据验证血糖风险指数DOI: 10.1177/19322968261489629
J Acquir Immune Defic Syndr IF: 02.900Ahead of Print.No.96Cross-sectional Comparison of the PREVENT and Pooled Cohort Equations for 10-Year Atherosclerotic Cardiovascular Risk Estimates in a U.S. Cohort of Black and Latina Transgender Women with HIVPREVENT与汇总队列方程在美国黑人及拉丁裔跨性别女性HIV感染者中10年动脉粥样硬化性心血管风险估计的横断面比较DOI: 10.1097/QAI.0000000000003985
J Diabetes Sci Technol IF: 03.700Ahead of Print.No.97Performance of a 15-Day Continuous Glucose Monitoring System in Children and Adolescents With Diabetes15天连续血糖监测系统在儿童和青少年糖尿病患者中的性能表现DOI: 10.1177/19322968261493981
Blood Pressure IF: 02.300Ahead of Print.No.98Epidemiology of Uncontrolled and Treatment‑Resistant Hypertension: A Registry‑Based Observational Study未控制高血压与难治性高血压的流行病学：一项基于注册的观察性研究DOI: 10.1080/08037051.2026.2749134
Curr Comput Aided Drug Des IF: 01.600Ahead of Print.No.99In silico and Network Pharmacology Identification of Acacia senegal Phytochemicals as Potential α-Amylase Inhibitors计算机模拟与网络药理学鉴定Acacia senegal植物化学物质作为潜在α-淀粉酶抑制剂DOI: 10.2174/0115734099489718260910060820
Current diabetes reviews IF: 01.900Ahead of Print.No.100Chronotherapeutic and Circadian Rhythm-Based Strategies in Diabetes Management: A Critical Opinion Based on Evidences糖尿病管理中的时间治疗与昼夜节律策略：基于证据的批判性观点DOI: 10.2174/0115733998495346261007070830
Endocrinol Diabetes Metab IF: 02.600Volume 9, Issue 6No.101Real-World Metabolic Improvements in Women With and Without Polyendocrine Metabolic Syndrome via a Multidisciplinary Telehealth Care Platform通过多学科远程医疗平台，患有多内分泌代谢综合征与不患该综合征的女性在真实世界中均获得代谢改善DOI: 10.1002/edm2.70332
Nanoscale IF: 05.100Ahead of Print.No.102Fibroblast-derived exosomes in wound healing and regenerative medicine: mechanisms, therapeutic potential, and clinical perspectives成纤维细胞来源外泌体在伤口愈合与再生医学中的机制、治疗潜力及临床前景DOI: 10.1039/d6nr01426g
Geriatr Gerontol Int IF: 02.500Volume 26, Issue 10No.103Comparison of Metabolic Dysfunction-Associated Steatotic Liver Disease Between Individuals With Werner Syndrome and Those With Insulin-Resistant Type 2 Diabetes: Hepatic Steatosis and Fibrosis IndicesWerner综合征患者与胰岛素抵抗型2型糖尿病患者代谢功能障碍相关脂肪性肝病的比较：肝脏脂肪变性和纤维化指标DOI: 10.1111/ggi.70866
Epidemiology and infection IF: 02.200Volume 154, Issue No.104Burden of RSV hospital disease and its comorbidities in adults in Spain (2016-2023)西班牙成人呼吸道合胞病毒住院疾病负担及其合并症（2016-2023年）DOI: 10.1017/S0950268826102076
Endocr Metab Immune Disord Drug Targets IF: 02.000Ahead of Print.No.105Study of Krüppel-like Factor 14 rs4731702 Polymorphism in Type 2 Diabetes MellitusKrüppel样因子14 rs4731702基因多态性与2型糖尿病的研究DOI: 10.2174/0118715303406864260803042753
Current organic synthesis IF: 02.500Ahead of Print.No.106L-Arginine Schiff Bases for Diabetic Wound Healing via Nitric Oxide Synthase Inhibition: Synthesis, In Vitro Activity, and In Silico InsightsL-精氨酸席夫碱通过抑制一氧化氮合酶促进糖尿病伤口愈合：合成、体外活性及计算机模拟研究DOI: 10.2174/0115701794490198260909153846
Phys Chem Chem Phys IF: 02.900Ahead of Print.No.107Delineating the structural distortions in hIAPP protofibrils by rationally designed hexapeptides using computer simulations利用计算机模拟解析理性设计的六肽对hIAPP原纤维的结构破坏作用DOI: 10.1039/d6cp01811d
Diabetes Technol Ther IF: 06.300Ahead of Print.No.108Efficacy and Safety of the MiniMed™ Vivera™ Algorithm: Results from a First-in-Human Feasibility TrialMiniMed™ Vivera™算法的有效性与安全性：首次人体可行性试验结果DOI: 10.1177/15209156261496632
Canadian liver journal IF: 01.200Volume 9, Issue 3No.109Cardiometabolic comorbidity and health outcomes of persons with metabolic dysfunction-associated steatotic liver disease (MASLD) in Ontario, Canada加拿大安大略省代谢功能障碍相关脂肪性肝病患者的代谢相关合并症与健康结局DOI: 10.3138/canlivj-2026-0020
Curēus IF: 01.300Volume 18, Issue 9No.110Recurrent Pericarditis With Cardiac Tamponade in a Patient With Systemic Lupus Erythematosus: A Case Report系统性红斑狼疮患者复发性心包炎伴心脏压塞：一例病例报告DOI: 10.7759/cureus.116182
Respir Med Case Rep IF: 00.800Volume 64, Issue No.111Early-onset severe voriconazole-induced liver injury with progressive cholestasis in pulmonary aspergillosis: A case report肺曲霉病患者中伏立康唑诱导的早发性严重肝损伤伴进行性胆汁淤积：一例病例报告DOI: 10.1016/j.rmcr.2026.102522
Curēus IF: 01.300Volume 18, Issue 9No.112Triple Renal Pathology in a Patient With Myeloperoxidase-Associated Vasculitis, Diabetic Nephropathy, and Immunoglobulin A Nephropathy: A Case Report一例髓过氧化物酶相关性血管炎、糖尿病肾病与免疫球蛋白A肾病三重肾脏病理的病例报告DOI: 10.7759/cureus.116188
Current opinion in endocrine and metabolic researchVolume 33, Issue No.113The Evolving Genomic Landscape of Pediatric Papillary Thyroid Cancer儿童甲状腺乳头状癌基因组景观的演变DOI: 10.1016/j.coemr.2023.100483
Drug Des Devel Ther IF: 05.100Volume 20, Issue No.114Oral Obesity Medicines in the Era of Cardiovascular-Kidney-Metabolic Syndrome (CKM): Beyond Weight Loss Toward Disease Modification心血管-肾脏-代谢综合征时代的口服减重药物：超越减重，迈向疾病修饰DOI: 10.2147/DDDT.S637685
Ethnicity & health IF: 02.000Ahead of Print.No.115The association between body mass index and perioperative outcomes by ethnicity and socioeconomic status: a systematic review of systematic reviews体重指数与围手术期结局的关联：基于种族和社会经济地位的系统综述再综述DOI: 10.1080/13557858.2026.2733954
Annals of plastic surgery IF: 01.600Ahead of Print.No.116Impact of Postbariatric Body Contouring Procedures on Patient Body Weight and Metabolism减重术后身体塑形手术对患者体重和代谢的影响DOI: 10.1097/SAP.0000000000004928
Clin Exp Rheumatol IF: 03.300Ahead of Print.No.117Phenotype-based risk stratification for deep vein thrombosis in Behçet's disease: a global 10-year longitudinal study基于表型的白塞病深静脉血栓风险分层：一项全球10年纵向研究DOI: 10.55563/clinexprheumatol/ir8mqc
JAMA surgery IF: 14.900Ahead of Print.No.118Bariatric Surgery and Risk of Obesity-Related Cancer by Age and Sex减重手术与肥胖相关癌症风险：年龄和性别的影响DOI: 10.1001/jamasurg.2026.4798
Curr Allergy Asthma Rep IF: 04.600Volume 26, Issue 1No.119Obesity-Related Asthma: Structure and Inflammation肥胖相关哮喘：结构与炎症DOI: 10.1007/s11882-026-01302-4
Brain imaging and behavior IF: 02.400Volume 20, Issue 5No.120The role of neighborhood socioeconomic environment in the association between glycemic control and the developing brain社区社会经济环境在血糖控制与大脑发育关联中的作用DOI: 10.1007/s11682-026-01211-0
Sleep & breathing IF: 02.000Volume 30, Issue 6No.121A dynamic triad: why weight trajectory matters in pediatric obesity, sleep apnea, and metabolic risk动态三联征：为何体重轨迹在儿童肥胖、睡眠呼吸暂停与代谢风险中至关重要DOI: 10.1007/s11325-026-03838-1
Acta diabetologica IF: 02.900Ahead of Print.No.122GLP-1 receptor agonists and hair loss: adverse effect, epiphenomenon, or therapeutic paradox?GLP-1受体激动剂与脱发：不良反应、伴随现象还是治疗悖论？DOI: 10.1007/s00592-026-02812-3
Acta diabetologica IF: 02.900Ahead of Print.No.123Risk of recurrent acute pancreatitis with GLP-1 receptor agonists after prior pancreatitis: a systematic review既往胰腺炎后使用GLP-1受体激动剂复发性急性胰腺炎的风险：一项系统评价DOI: 10.1007/s00592-026-02809-y
Acta diabetologica IF: 02.900Ahead of Print.No.124Gestational diabetes mellitus in Italian diabetes clinics: clinical characteristics, screening practices and management from the amd annals registry意大利糖尿病诊所中的妊娠期糖尿病：来自AMD Annals注册中心的临床特征、筛查实践与管理DOI: 10.1007/s00592-026-02816-z
Journal of dental research IF: 05.900Ahead of Print.No.125GLP-1 Receptor Agonists in Dentistry: Promise, Pitfalls, and Evidence GapsGLP-1受体激动剂在牙科中的应用：前景、隐患与证据空白DOI: 10.1177/00220345261488338
Small IF: 12.100Ahead of Print.No.126Fenestrated Microneedle Biosensor for Continuous In Vivo Lactate Monitoring in Interstitial Fluid用于连续体内间质液乳酸监测的开窗微针生物传感器DOI: 10.1002/smll.76250
Expert Opin Pharmacother IF: 02.700Ahead of Print.No.127Obesity: oral therapy for those afraid of needles肥胖症：针对恐针患者的口服治疗DOI: 10.1080/14656566.2026.2749645
Current diabetes reviews IF: 01.900Ahead of Print.No.128Gliflozin-Derived SGLT2 Inhibitors: Recent Advances and Future Perspectives in the Management of Type 2 Diabetes格列净衍生的SGLT2抑制剂：2型糖尿病管理的最新进展与未来展望DOI: 10.2174/0115733998505609261006104914
Current drug delivery IF: 03.000Ahead of Print.No.129Pharmacological and Therapeutic Roles of Wild Pistachio and Its Nanoformulations in Endocrine, Metabolic, and Other Diseases: A Comprehensive Review野生开心果及其纳米制剂在内分泌、代谢及其他疾病中的药理与治疗作用：一项综合性综述DOI: 10.2174/0115672018452820261006095941
Strabismus IF: 00.800Ahead of Print.No.130Potocki-Shaffer syndrome associated with Brown syndrome: expansion of the ocular phenotype in a child with an 11p11.2-p11.12 deletionPotocki-Shaffer综合征合并Brown综合征：一例11p11.2-p11.12缺失患儿眼部表型的扩展DOI: 10.1080/09273972.2026.2746025
J Pediatr Gastroenterol Nutr IF: 02.600Ahead of Print.No.131Chronic conditions associated with paediatric onset inflammatory bowel diseases: A population-based study与儿童期起病炎症性肠病相关的慢性疾病：一项基于人群的研究DOI: 10.1002/jpn3.70609
Health Care Women Int IF: 00.900Ahead of Print.No.132Effects of 6- versus 12-week supervised multimodal exercise on health outcomes and adherence in women with obesity: A pilot study6周与12周监督下多模式运动对肥胖女性健康结局和依从性的影响：一项初步研究DOI: 10.1080/07399332.2026.2743908
J Pediatr Endocrinol Metab IF: 01.000Ahead of Print.No.133Fatty liver and adipokines: converging pathways linking insulin resistance to early atherosclerosis in obese children and adolescents脂肪肝与脂肪因子：肥胖儿童和青少年中连接胰岛素抵抗与早期动脉粥样硬化的汇聚通路DOI: 10.1515/jpem-2026-0302
J Clin Pharmacol IF: 02.300Volume 66, Issue 10No.134Mechanistic Prediction of Maternal, Fetal, and Amniotic Fluid Betamethasone Concentrations to Support Dosing Optimization in Pregnancy母体、胎儿及羊水中倍他米松浓度的机制性预测以支持妊娠期给药优化DOI: 10.1002/jcph.70308
J Clin Med Res IF: 02.000Volume 18, Issue 9No.135Common Carotid Artery Extra-Media Thickness as a Marker of Perivascular Obesity and Cardiometabolic Risk in Individuals Without Cardiovascular Disease颈总动脉外膜厚度作为无心血管疾病个体血管周围肥胖和心脏代谢风险的标志物DOI: 10.14740/jocmr6657
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.136Diabetes Mellitus in Patients with Schizophrenia: A Systematic Review and Meta-Analysis of Prevalence of Types and Risk Factors精神分裂症患者的糖尿病：类型患病率与风险因素的系统综述与荟萃分析DOI: 10.2147/DMSO.S650265
Canadian liver journal IF: 01.200Volume 9, Issue 3No.137Metabolic dysfunction-associated steatotic liver disease assessment and management: Clinical practice guidance from the Canadian Association for the Study of the Liver代谢功能障碍相关脂肪性肝病的评估与管理：加拿大肝病研究学会临床实践指南DOI: 10.3138/canlivj-2026-9-3-guidelines
Frontiers in toxicology IF: 04.600Volume 8, Issue No.138Mapping DEHP-induced metabolic dysregulation through multi-omics and systems biology: an adverse outcome pathway network approach通过多组学和系统生物学解析DEHP诱导的代谢失调：有害结局路径网络方法DOI: 10.3389/ftox.2026.1930835
Aesthet Surg J Open Forum IF: 01.900Volume 8, Issue No.139The Impact of Glucagon-Like Peptide-1 Receptor Agonist-Induced Nutritional Deficiencies on Skin Health: A Narrative Review With a Proposed Framework for the Aesthetic Practitioner胰高血糖素样肽-1受体激动剂诱导的营养缺乏对皮肤健康的影响：叙述性综述及为美容从业者提出的框架DOI: 10.1093/asjof/ojag169
Journal of the Endocrine Society IF: 03.100Volume 10, Issue 11No.140Potential links between PCOS/PMOS and Alzheimer disease and related dementias多囊卵巢综合征/多内分泌代谢性卵巢综合征与阿尔茨海默病及相关痴呆的潜在关联DOI: 10.1210/jendso/bvag206
Hepatobiliary Surg Nutr IF: 07.800Volume 15, Issue 5No.141Body mass index and ampulla of Vater cancer incidence and survival: a cohort study of 1.7 million Norwegians体重指数与Vater壶腹癌发病率和生存率：一项170万挪威人的队列研究DOI: 10.21037/hbsn-2024-636
Hepatobiliary Surg Nutr IF: 07.800Volume 15, Issue 5No.142Normal weight, hidden risk: adiposity is a better determinant of liver cancer than body mass index正常体重，隐藏风险：脂肪堆积比体重指数更能决定肝癌风险DOI: 10.21037/hbsn-2026-0411
BMFH IF: 02.900Volume 45, Issue 4No.143Bifidobacterium adolescentis protects the intestinal barrier from obesity-related inflammatory stimuli in association with the nuclear translocation of nuclear factor kappa B青春双歧杆菌通过核因子κB核转位保护肠道屏障免受肥胖相关炎症刺激DOI: 10.12938/bmfh.2026-022
Acta gastroenterológica latinoamericanaVolume 56, Issue 3No.144Glucagon-Like Peptide-1 Receptor Agonist and Gastrointestinal Adverse Effects: A Comprehensive Review胰高血糖素样肽-1受体激动剂与胃肠道不良反应：综合综述DOI: 10.52787/agl.v56i3.690
Int J Womens Health IF: 02.600Volume 18, Issue No.145Burden, Trends, and Future Projections of Polycystic Ovary Syndrome in the Gulf Cooperation Council Countries, 1990-2023, with Projections to 2050: A Global Burden of Disease Study海湾合作委员会国家多囊卵巢综合征的疾病负担、趋势及未来预测（1990-2023年，并预测至2050年）：一项全球疾病负担研究DOI: 10.2147/IJWH.S644317
Przegl?d Menopauzalny IF: 01.700Volume 25, Issue 2No.146Associations between body composition, physical activity, and life satisfaction in perimenopausal women aged 40-50 years: a cross-sectional study40-50岁围绝经期女性体重指数、体力活动与生活满意度的关联：一项横断面研究DOI: 10.5114/pm.2026.163868
BMJ Global Health IF: 06.100Volume 11, Issue 10No.147Estimating the potential health impact of taxing sugar-sweetened drinks in Thailand: a modelling study估算泰国对含糖饮料征税的潜在健康影响：一项建模研究DOI: 10.1136/bmjgh-2025-021625
Nature IF: 48.500Ahead of Print.No.148Artificial intelligence-enabled clinical phenotyping of human brown fat - Nature人工智能赋能的人类棕色脂肪临床表型分析DOI: 10.1038/s41586-026-11162-7
Frontiers in medicine IF: 03.000Volume 13, Issue No.149Cross-modal fusion of OCT and OCT angiography enface for improved diagnostics of diabetic retinopathyOCT与OCTA enface的跨模态融合提升糖尿病视网膜病变诊断效能DOI: 10.3389/fmed.2026.1900570
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.150Investigating the effect of diet-induced prediabetes on the HPA-axis, sympathetic nervous system and endogenous opioids in male Sprague-Dawley rats探究饮食诱导的糖尿病前期对雄性Sprague-Dawley大鼠HPA轴、交感神经系统及内源性阿片系统的影响DOI: 10.3389/fendo.2026.1925577
Frontiers in nephrologyVolume 6, Issue No.151SGLT2 inhibitors as a strategy for volume management in peritoneal dialysis: a case series钠-葡萄糖协同转运蛋白2抑制剂作为腹膜透析容量管理策略：病例系列DOI: 10.3389/fneph.2026.1942462
FCVM IF: 02.900Volume 13, Issue No.152Cardiovascular outcomes of oral incretin-based drugs in type 2 diabetes: a GRADE-assessed meta-analysis of 67,679 patients口服肠促胰素类药物在2型糖尿病中的心血管结局：一项纳入67,679例患者的GRADE评估荟萃分析DOI: 10.3389/fcvm.2026.1884895
Med J Islam Repub IranVolume 40, Issue No.153Latent Class Analysis for Clustering Iranian Individuals Based on Cardiovascular Risk Factors基于心血管危险因素对伊朗个体进行聚类分析的潜在类别分析DOI: 10.47176/mjiri.40.88
3 biotech IF: 02.900Volume 16, Issue 11No.154Machine learning-driven discovery of TGFBR1 inhibitors from Mangifera indica for Atorvastatin-based antidiabetic therapy机器学习驱动的芒果中TGFBR1抑制剂发现及其用于基于阿托伐他汀的降糖治疗DOI: 10.1007/s13205-026-05088-0
JCEM case reportsVolume 4, Issue 11No.155Aortic coarctation and McArdle disease in histiocytosis-lymphadenopathy plus syndrome: expanding the SLC29A3 spectrum组织细胞增生症-淋巴结病附加综合征中的主动脉缩窄与McArdle病：扩展SLC29A3谱系DOI: 10.1210/jcemcr/luag289
JCEM case reportsVolume 4, Issue 11No.156Hypoinsulinemic hypoglycemia with hemihypertrophy in a Filipino infant: management in a resource-limited setting一例菲律宾婴儿低胰岛素性低血糖伴偏身肥大：资源有限环境下的管理DOI: 10.1210/jcemcr/luag231
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.157Commentary: Pembrolizumab-induced type-1 diabetes mellitus: clinical characteristics, therapeutic strategies, and prognosis from a retrospective analysis of 43 published cases评论：帕博利珠单抗诱导的1型糖尿病——基于43例已发表病例回顾性分析的临床特征、治疗策略与预后DOI: 10.3389/fendo.2026.1986405
Frontiers in nutrition IF: 05.100Volume 13, Issue No.158Comparative accuracy of automated carbohydrate estimation using NutriDish and ChatGPT-5 against dietitian-derived reference valuesNutriDish与ChatGPT-5自动估算碳水化合物的准确性比较：以营养师推导的参考值为基准DOI: 10.3389/fnut.2026.1927840
Med J Islam Repub IranVolume 40, Issue No.159Introducing Prostaglandin Endoperoxide Synthase-2 as a Remarkable Player in the Development of Gastroesophageal Reflux Disease前列腺素内过氧化物合酶-2在胃食管反流病发展中的重要作用DOI: 10.47176/mjiri.40.78
Indian journal of orthopaedics IF: 01.100Volume 60, Issue 10No.160Predictors of Non-union in Subtrochanteric Femur Fractures: A Multivariate Logistic Regression Analysis股骨转子下骨折不愈合的预测因素：多因素Logistic回归分析DOI: 10.1007/s43465-026-01882-3
Curēus IF: 01.300Volume 18, Issue 9No.161Predictive Factors for Diabetes Insipidus and Syndrome of Inappropriate Secretion of Antidiuretic Hormone After Transsphenoidal Surgery for Pituitary Adenoma垂体腺瘤经蝶手术后尿崩症与抗利尿激素不适当分泌综合征的预测因素DOI: 10.7759/cureus.116176
Med J Islam Repub IranVolume 40, Issue No.162Diabetes Status and the Association Between a Coronary Artery Disease Polygenic Risk Score and Incident Coronary Artery Disease in an Iranian Prospective Cohort糖尿病状态与伊朗前瞻性队列中冠状动脉疾病多基因风险评分及新发冠状动脉疾病之间的关联DOI: 10.47176/mjiri.40.89
AME case reports IF: 00.700Volume 10, Issue No.163Where did the iron go?-a case report of a patient with severe iron deficiency anemia despite parenteral and oral iron supplementation due to semaglutide application铁去哪儿了？——一例因应用司美格鲁肽导致尽管接受肠外和口服铁补充仍出现严重缺铁性贫血患者的病例报告DOI: 10.21037/acr-2026-0027
Indian journal of orthopaedics IF: 01.100Volume 60, Issue 10No.164Occurrence and Determinants of Periprosthetic Fractures of the Femur During Intraoperative and Post-operative Period in Patients Undergoing Hip Arthroplasty: A Prospective Cohort Study髋关节置换术患者术中及术后股骨假体周围骨折的发生率及决定因素：一项前瞻性队列研究DOI: 10.1007/s43465-026-01808-z
JCEM case reportsVolume 4, Issue 11No.165Primary adrenal small cell neuroendocrine carcinoma in a patient with sarcoidosis and synchronous colon adenocarcinoma结节病合并同步升结肠腺癌患者中原发性肾上腺小细胞神经内分泌癌一例DOI: 10.1210/jcemcr/luag313
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.166The CKM-GDM multi-organ precision model: reframing gestational diabetes as an early cardiovascular-kidney-metabolic event in Southeast AsiaCKM-GDM多器官精准模型：将妊娠期糖尿病重新定义为东南亚地区早期心血管-肾脏-代谢事件DOI: 10.3389/fendo.2026.1949130
FCVM IF: 02.900Volume 13, Issue No.167Effect of rosuvastatin and ezetimibe therapy on LDL-cholesterol reduction and non-invasive arterial injury markers in children with heterozygous familial hypercholesterolemia: a prospective, open-label, randomized study瑞舒伐他汀与依折麦布治疗对杂合子家族性高胆固醇血症儿童低密度脂蛋白胆固醇降低及无创动脉损伤标志物的影响：一项前瞻性、开放标签、随机研究DOI: 10.3389/fcvm.2026.1933757
Indian journal of orthopaedics IF: 01.100Volume 60, Issue 10No.168Body Mass Index-Related Changes in Tibial Morphology: Considerations for Intramedullary Nailing体重指数相关的胫骨形态变化：髓内钉置入的考量DOI: 10.1007/s43465-026-01921-z
Int J Hypertens IF: 01.700Volume 2026, Issue No.169From Adiposity to Diastolic Dysfunction: The Integrated Role of Epicardial Fat, Autonomic Dysregulation, and Morning Blood Pressure Surge in Obesity从肥胖到舒张功能障碍：心外膜脂肪、自主神经失调与晨峰血压在肥胖中的整合作用DOI: 10.1155/ijhy/8528281
J Diabetes Metab Disord IF: 01.600Volume 25, Issue 2No.170The hepato-thyroid axis in male obesity: unraveling inter-organ crosstalk through non-invasive biomarkers男性肥胖中的肝-甲状腺轴：通过无创生物标志物揭示器官间串扰DOI: 10.1007/s40200-026-02107-y
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.171The role of sitagliptin in modifying metabolic, hormonal and clinical parameters in polycystic ovarian syndrome patients: a randomized controlled trial西格列汀对多囊卵巢综合征患者代谢、激素及临床指标的影响：一项随机对照试验DOI: 10.3389/fphar.2026.1822226
AME case reports IF: 00.700Volume 10, Issue No.172Urogenital abscess with a complex etiology: a case report复杂病因的泌尿生殖系统脓肿：一例病例报告DOI: 10.21037/acr-2026-0132
Frontiers in Nuclear MedicineVolume 6, Issue No.173Absolute stress myocardial blood flow is reduced in patients with prior cardiac disease despite normal perfusion and ejection fraction on rubidium-82 PET: an Arabian Gulf cohort阿拉伯湾队列研究：既往心脏病患者尽管灌注和射血分数正常，但绝对负荷心肌血流量降低：一项铷-82 PET研究DOI: 10.3389/fnume.2026.1957482
N Am Spine Soc J IF: 02.500Volume 28, Issue No.174GLP-1 receptor agonists in elective spine surgery: a systematic review of fusion outcomes, perioperative safety, and procedure-specific risk胰高血糖素样肽-1受体激动剂在择期脊柱手术中的应用：融合结局、围手术期安全性和手术特异性风险的系统综述DOI: 10.1016/j.xnsj.2026.100942
DEN open IF: 01.500Volume 7, Issue 1No.175Evaluating a Modified American Society of Anesthesiologists Physical Status-Based Sedation Management System for Pancreatobiliary Endoscopy: A Prospective Feasibility Study评估基于改良美国麻醉医师协会体能状态分级的胰胆内镜镇静管理系统：一项前瞻性可行性研究DOI: 10.1002/deo2.70445
Afr J Reprod Health IF: 01.000Volume 30, Issue 19No.176Maternal risk factors for hypertension in pregnancy: A quantitative study on the role of demographics, obesity, and healthcare compliance妊娠期高血压的母体风险因素：关于人口统计学、肥胖和医疗依从性作用的定量研究DOI: 10.29063/ajrh2026/v30i19.7
Frontiers in immunology IF: 05.900Volume 17, Issue No.177Saccharomyces boulardii reduces food intake and attenuates weight gain in diet-induced obese mice: links to gut microbial, metabolic, and immune remodeling布拉氏酵母菌减少饮食诱导肥胖小鼠的进食量并减轻体重增长：与肠道微生物、代谢及免疫重塑的关联DOI: 10.3389/fimmu.2026.1925200
Hypertension Research IF: 04.600Ahead of Print.No.178Pre-pregnancy BMI and hypertensive disorders of pregnancy in Japan: population burden and simulated BMI reduction scenarios for preconception and interpregnancy care日本孕前体重指数与妊娠期高血压疾病：人群负担及孕前和孕期保健中模拟体重指数降低情景DOI: 10.1038/s41440-026-02847-7
Arthritis & rheumatology IF: 10.900Ahead of Print.No.179Higher risk of Long COVID among patients with autoimmune rheumatic diseases and immunomodulatory therapy: a retrospective cohort analysis of national US data自身免疫性风湿病患者和免疫调节治疗中Long COVID风险更高：一项基于美国国家数据的回顾性队列分析DOI: 10.1002/art.70361
Nutrition journal IF: 03.800Volume 25, Issue 1No.180Intake of ultra-processed foods in Sweden and its association with diet quality and weight status: cross-sectional analyses from three national dietary surveys瑞典超加工食品摄入及其与膳食质量和体重状况的关联：来自三项全国膳食调查的横断面分析DOI: 10.1186/s12937-026-01408-5
Dermatology and therapy IF: 04.200Ahead of Print.No.181Obesity and Early Biologic Failure in Psoriasis: An Italian Multicentre Retrospective Cohort Study肥胖与银屑病早期生物制剂治疗失败：一项意大利多中心回顾性队列研究DOI: 10.1007/s13555-026-01956-y
J Gen Intern Med IF: 04.200Ahead of Print.No.182Self-Reported Obesity Medicine Competence, Knowledge, and Attitudes Among US Medical Students: An Eight-School Pre- vs. Post-Intervention Study美国医学生自我报告的肥胖医学能力、知识和态度：一项八所学校干预前后研究DOI: 10.1007/s11606-026-10913-6
Eur Arch Psychiatry Clin Neurosci IF: 03.700Ahead of Print.No.183Testing whether prolactin and glucose associations differ by sex检验催乳素与血糖的关联是否存在性别差异DOI: 10.1007/s00406-026-02406-8
Communications biology IF: 05.100Volume 9, Issue 1No.184KCNQ1 disruption alters human neuronal development through mitochondrial and insulin signalling pathwaysKCNQ1缺失通过线粒体和胰岛素信号通路改变人类神经元发育DOI: 10.1038/s42003-026-11111-0
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.185Reappraising the Role of GH/IGF-I Axis and β-Cell Failure: Insights From Two Genetic Syndromes重新评估GH/IGF-I轴与β细胞衰竭的作用：来自两种遗传综合征的启示DOI: 10.1111/dom.71386
Proteomics IF: 03.900Ahead of Print.No.186Meet the Editorial Team. An Interview With Prof David Greening, Associate Editor, Proteomics, Baker Heart and Diabetes Institute, Melbourne, Australia认识编辑团队：专访澳大利亚墨尔本贝克心脏与糖尿病研究所蛋白质组学副主编David Greening教授DOI: 10.1002/pmic.70191
Crit Rev Ther Drug Carrier Syst IF: 02.500Volume 43, Issue 3No.187Stimuli-Responsive Wound Management: A Focus on Innovative pH-Driven Healing Systems刺激响应性伤口管理：聚焦创新的pH驱动愈合系统DOI: 10.1615/CritRevTherDrugCarrierSyst.2026058031
Nepal J Ophthalmol IF: 00.200Volume 17, Issue 34No.188Corneal Endothelial Morphology in Type II Diabetic versus Non-Diabetic Individuals using Specular Microscopy使用镜面显微镜比较II型糖尿病患者与非糖尿病个体的角膜内皮形态DOI: 10.3126/nepjoph.v17i34.74598
Arthroscopy : IF: 05.400Ahead of Print.No.189Arthroscopic Bankart Repair Is Associated With Lower 90-Day Emergency Department Use Than Open Repair, With Smoking, Medicaid Insurance, and Depression as Additional Independent Predictors关节镜Bankart修复术相比开放修复术与更低的90天急诊使用相关，吸烟、Medicaid保险和抑郁是额外的独立预测因素DOI: 10.1002/arj.70639
Nepal J Ophthalmol IF: 00.200Volume 18, Issue 35No.190Severity of Primary Open Angle Glaucoma at First Presentation and Associated Factors in Tertiary Hospital三级医院中原发性开角型青光眼首次就诊时的严重程度及相关因素DOI: 10.3126/nepjoph.v18i35.82846
Egyptian Journal of ImmunologyVolume 33, Issue 4No.191Impact of probiotic supplementation on serum klotho levels and inflammatory status in patients with diabetic kidney disease补充益生菌对糖尿病肾病患者血清klotho水平及炎症状态的影响DOI: 10.55133/eji.330404
IUBMB life IF: 03.200Volume 78, Issue 10No.192The Receptor for Advanced Glycation End Products: Regulation and Implications in Metabolic Diseases晚期糖基化终产物受体：在代谢性疾病中的调控与意义DOI: 10.1002/iub.70137
Can J Public Health IF: 02.600Ahead of Print.No.193Self-reported impact of the sugar-sweetened beverage tax on consumer attitudes among adults in Newfoundland and Labrador: A comparison with other Canadian provinces in 2021 and 2022含糖饮料税对Newfoundland and Labrador成年人消费者态度自我报告影响的比较研究：2021年和2022年与加拿大其他省份的对比DOI: 10.17269/s41997-026-01259-x
European journal of pediatrics IF: 02.600Volume 185, Issue 11No.194Exercise management in pediatric type 1 diabetes: a multicenter study of healthcare professionals' perspectives儿童1型糖尿病的运动管理：一项关于医疗保健专业人员观点的多中心研究DOI: 10.1007/s00431-026-07472-7
Prostate Cancer Prostatic Dis IF: 05.800Ahead of Print.No.195Fracture risk and fracture risk factor assessment among men at prostate cancer diagnosis前列腺癌诊断时男性的骨折风险及骨折风险因素评估DOI: 10.1038/s41391-026-01151-2
J Gen Intern Med IF: 04.200Ahead of Print.No.196Representation of the LGBTQIA+ Patient Community in Cardiovascular Disease Clinical GuidelinesLGBTQIA+患者群体在心血管疾病临床指南中的代表性DOI: 10.1007/s11606-026-10857-x
Nepal J Ophthalmol IF: 00.200Volume 17, Issue 34No.197Real-world Outcomes and Predictors of Vision Loss after Panretinal Photocoagulation for Diabetic Retinopathy: Five-year Follow-up全视网膜光凝治疗糖尿病视网膜病变后的真实世界结局与视力丧失预测因素：五年随访DOI: 10.3126/nepjoph.v17i34.86992
Nepal J Ophthalmol IF: 00.200Volume 17, Issue 34No.198Awareness, Knowledge, and Practice on Retinal Diseases at High-altitude of Nepal尼泊尔高海拔地区视网膜疾病的意识、知识与实践DOI: 10.3126/nepjoph.v17i34.68246
Epidemiology and infection IF: 02.200Volume 154, Issue No.199Presence of post-COVID-19 condition in six ethnic groups in Amsterdam, the Netherlands: a retrospectively reconstructed time interval approach荷兰阿姆斯特丹六个族裔群体中COVID-19后状况的存在情况：一项回顾性重建时间间隔方法研究DOI: 10.1017/S095026882610199X
Biomed Environ Sci IF: 04.100Volume 39, Issue 9No.200Long-term National Trends in the Prevalence of Type 2 Diabetes Mellitus and the Association with Social Determinants of Health in Korean Adults, 2007-20242007-2024年韩国成人2型糖尿病患病率的长期全国趋势及其与社会健康决定因素的关联DOI: 10.3967/bes2026.090
Toxicol Mech Methods IF: 02.700Ahead of Print.No.201Molecular Toxicological Mechanisms of Pharmaceutical Nitrosamines: DNA Damage, Metabolic Activation, Carcinogenesis, and Advanced Analytical Detection Strategies药物亚硝胺的分子毒理学机制：DNA损伤、代谢活化、致癌作用及先进分析检测策略DOI: 10.1080/15376516.2026.2749670
BMC pharmacology & toxicology IF: 02.700Volume 27, Issue 1No.202Correction to: In vitro comparative quality evaluation of different brands of metformin hydrochloride tablets available in Mekelle City, Tigray Regional State, Ethiopia更正：埃塞俄比亚提格雷州默克莱市市售不同品牌盐酸二甲双胍片的体外质量比较评价DOI: 10.1186/s40360-026-01202-3
Nepal J Ophthalmol IF: 00.200Volume 17, Issue 34No.203Evaluation of Optical Coherence Tomography Angiography Parameters following Intravitreal Ranibizumab Biosimilar in Diabetic Macular Oedema玻璃体腔注射雷珠单抗生物类似药治疗糖尿病性黄斑水肿后光学相干断层扫描血管成像参数的评估DOI: 10.3126/nepjoph.v17i34.69532
Nepal J Ophthalmol IF: 00.200Volume 18, Issue 35No.204Retinal Nerve Fibre Layer and Ganglion Cell Complex Thickness in Diabetes Mellitus without Diabetic Retinopathy无糖尿病视网膜病变的糖尿病患者视网膜神经纤维层和神经节细胞复合体厚度研究DOI: 10.3126/nepjoph.v18i35.75209
Nepal J Ophthalmol IF: 00.200Volume 18, Issue 35No.205Visual Outcomes of Ranibizumab Versus Bevacizumab in Diabetic Retinopathy: An Analytical Study雷珠单抗与贝伐珠单抗治疗糖尿病视网膜病变的视觉结局：一项分析性研究DOI: 10.3126/nepjoph.v18i35.82606
J Long Term Eff Med ImplantsVolume 36, Issue 2No.206Influence of Metabolic Syndrome on Peri-Implant Tissue Health and Disease: A Comparative Evaluation of Clinical, Radiographic, and Red Complex Microbiological Parameters代谢综合征对种植体周围组织健康与疾病的影响：临床、影像学和红色复合体微生物学参数的比较评估DOI: 10.1615/JLongTermEffMedImplants.2025061104
J Microbiol Biotechnol IF: 03.100Volume 36, Issue No.207Isolation and Characterization of Levilactobacillus brevis FBL-3 from Godeulppaegi Kimchi and Screening of Medium Components for γ-Aminobutyric Acid Production从Godeulppaegi Kimchi中分离鉴定Levilactobacillus brevis FBL-3及产γ-氨基丁酸培养基组分筛选DOI: 10.4014/jmb.2608.08011
BMC endocrine disorders IF: 03.300Volume 26, Issue 1No.208Levothyroxine dose requirements, oral bioavailability and gut microbiome enterotype dynamics during the early post-bariatric period: a single-centre, prospective, cohort study减重手术后早期左甲状腺素剂量需求、口服生物利用度及肠道微生物组肠型动态：一项单中心、前瞻性、队列研究DOI: 10.1186/s12902-026-02599-y
J Long Term Eff Med ImplantsVolume 36, Issue 2No.209Harnessing the Therapeutic Potential of Locally Delivered 1% Metformin Gel for Modulation of Clinical and Inflammatory Parameters in Peri-Implantitis Disease: A Prospective Clinical Evaluation利用局部递送1%二甲双胍凝胶调节种植体周围炎临床和炎症参数的治疗潜力：一项前瞻性临床评估DOI: 10.1615/JLongTermEffMedImplants.2025062172
Chemistry & biodiversity IF: 02.500Volume 23, Issue 10No.210Bioactive Compounds and Antidiabetic Properties of Launaea mucronata Hydroethanolic Extract: Phytochemical and Pharmacological InsightsLaunaea mucronata 氢乙醇提取物的生物活性化合物与抗糖尿病特性：植物化学与药理学见解DOI: 10.1002/cbdv.71780
Acta neuropsychiatrica IF: 02.500Volume 38, Issue No.211Effects of glucagon-like peptide-1 (GLP-1) mono-agonists on reward processing in animal models: a systematic review胰高血糖素样肽-1（GLP-1）单激动剂对动物模型奖赏加工的影响：一项系统综述DOI: 10.1017/neu.2026.10097
Alzheimer's & dementia IF: 11.100Volume 22, Issue 10No.212Sphingolipid and ceramide associations with tau pathology vary across diverse ethnoracial groups in postmortem brain tissue死后脑组织中鞘脂和神经酰胺与tau病理的关联在不同种族群体中存在差异DOI: 10.1002/alz.71690
Expert Opin Pharmacother IF: 02.700Ahead of Print.No.213Pharmacotherapy for MASLD/MASH: approved therapies, drug repurposing, and emerging mechanism-based candidatesMASLD/MASH的药物治疗：已获批疗法、药物重定位及新兴机制候选药物DOI: 10.1080/14656566.2026.2749643
J Clin Endocrinol Metab IF: 05.100Ahead of Print.No.214Iopanoic Acid in Severe Thyrotoxicosis: Rediscovering an Effective Therapy碘番酸在严重甲状腺毒症中的应用：重新发现一种有效疗法DOI: 10.1210/clinem/dgag421
204
Diabetes Mellitus(DM)
糖尿病
95
Obesity
肥胖症
54
Insulin
胰岛素
29
Type 2 diabetes mellitus(T2DM)
2型糖尿病
16
Semaglutide
司美格鲁肽
15
Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA)
胰高血糖素样肽-1受体激动剂
12
Diabetic Retinopathy
糖尿病视网膜病
9
Metformin
二甲双胍
7
Tirzepatide
替尔泊肽
7
Metabolic Syndrome
代谢综合征
5
Liraglutide
利拉鲁肽
4
Type 1 diabetes mellitus(T1DM)
1型糖尿病
4
Hypoglycemic Agents
降糖药
4
Diabetic Foot
糖尿病足
4
Diabetes Complications
糖尿病并发症
3
Diabetic acidosis
糖尿病性酸中毒
3
Sotagliflozin
索格列净
3
Dapagliflozin
达格列净
3
Pregabalin
普瑞巴林
3
Diabetic Peripheral Neuropathy(PDN)
糖尿病周围神经病变
3
Gestational Diabetes Mellitus(GDM)
妊娠糖尿病
3
Dulaglutide
度拉糖肽
3
gamma-Aminobutyric Acid(GABA)
γ-氨基丁酸
2
Exenatide
艾塞那肽
2
Gastrointestinal lipase inhibitor
胃肠道脂肪酶抑制剂
2
Orlistat
奥利司他
2
Empagliflozin
恩格列净
2
Sitagliptin
西他列汀
1
Diabetic Cardiomyopathies
糖尿病心肌病
1
Ertugliflozin
艾托格列净
1
Bexagliflozin
贝沙格列净
1
Canagliflozin
卡格列净
1
Alzheimer Disease and Diabetes Mellitus
阿尔茨海默病与糖尿病
1
Mazdutide
玛仕度肽
1
Orforglipron
奥氟格列隆
1
Diabetic Kidney Disease(DKD)
糖尿病肾脏病
1
Diabetic Neuropathies
糖尿病性神经病变
1
Dipeptidyl-Peptidase IV Inhibitors(DPP-4i)
二肽基肽酶-4抑制剂
1
Lixisenatide
利司那肽
1
Gabapentin
加巴喷丁
编辑：韩玉莲
审校：韩玉莲
临床结果
2026-10-14
·我药说说
0. 一句话速览
通化东宝（600867.SH），中国"胰岛素双雄"里的另一位——不是甘李那样靠三代胰岛素类似物起家的"技术狠人"，而是一家从1985年吉林通化长白山下走出来的老牌药企，靠"人胰岛素"这一块最朴素、也最刚需的蛋糕，坐了三十多年国产胰岛素头把交椅。它的名字里藏着中国胰岛素产业半部创业史：创始人李一奎，当年正是"甘李"二字里的那个"李"——甘忠如的"甘"加上李一奎的"李"，共同孵化了后来分道扬镳的甘李药业。
但这家"老大哥"在2024年，迎来了上市以来第一次归母净利润亏损：受胰岛素第二轮集采降价、渠道库存补差、以及一个从法国ADOCIA公司买来的双胰岛素项目"翻车"三记重锤叠加，全年营收20.10亿元、净利-0.43亿元。到了2025年，它又以一种近乎戏剧性的方式"满血复活"——营收29.47亿元、净利12.19亿元，扭亏为盈；2026年上半年继续增长，营收15.53亿元、净利2.96亿元。
通化东宝的故事，是一个典型的"老牌药企如何在集采的血海里、在技术迭代的洪流里，艰难寻找第二增长曲线"的故事。它的基本盘（人胰岛素+胰岛素类似物）依然稳健，市占率国内第一；它的第二曲线（GLP-1赛道）也早已埋下伏笔——利拉鲁肽已经卖到了17个海外国家，司美格鲁肽、德谷胰岛素利拉鲁肽复方、GLP-1/GIP双靶点创新药都在路上。但它也背负着"源头创新弱、依赖外部引进"的软肋，以及控股股东高比例质押的隐忧。读懂通化东宝，就读懂了半个中国糖尿病用药的国运变迁。
1. 它是一家什么样的公司
通化东宝的全称是"通化东宝药业股份有限公司"，注册地和总部都在吉林省通化市通化县东宝新村。公司始建于1985年，1994年8月24日在上海证券交易所上市，是A股最早的一批医药上市公司之一，股票代码600867，到2026年已经上市三十多年，是一家不折不扣的"医药老字号"。
公司的实际控制人是李一奎。截至2026年8月，控股股东东宝实业集团股份有限公司持股31.63%，李一奎个人直接持股0.58%，是公司的灵魂人物和掌舵者。公司的法定代表人（董事长）是李佳鸿，董事会秘书是吴灵犀。
通化东宝的主营业务，一句话就能说清：它是中国最大的"人胰岛素"生产企业，同时正在加速向胰岛素类似物和GLP-1赛道升级。 具体产品线可以分为几块：
（1）人胰岛素系列（基本盘，市占率国内第一）。 这是通化东宝最老、也最稳的家底，包括人胰岛素注射液、精蛋白人胰岛素注射液、精蛋白人胰岛素混合注射液（30R/40R/50R）等。人胰岛素是"第二代胰岛素"，通过基因工程重组技术生产，相比第一代动物胰岛素，纯度更高、免疫原性更低。通化东宝在这一领域深耕数十年，据医药魔方销量数据，2024年公司人胰岛素产品市场占有率攀升至43.7%，稳居国内第一。
（2）胰岛素类似物系列（升级盘，正在放量）。 这是通化东宝近几年主攻的"第三代胰岛素"，包括甘精胰岛素注射液、门冬胰岛素注射液、门冬胰岛素30注射液、门冬胰岛素50注射液。胰岛素类似物是在人胰岛素基础上改造氨基酸序列，更符合生理性分泌曲线，是当下糖尿病治疗的主流。这是通化东宝从"二代"向"三代"跨越的关键。
（3）口服降糖药与GLP-1等新品（第二曲线）。 利拉鲁肽注射液（GLP-1受体激动剂）、恩格列净片（SGLT-2抑制剂）、磷酸西格列汀片（DPP-4抑制剂）、瑞格列奈片、依托考昔片（痛风/镇痛），以及传统中成药镇脑宁胶囊等。
（4）在研管线（未来牌）。 司美格鲁肽注射液、德谷胰岛素利拉鲁肽注射液、GLP-1/GIP双靶点受体激动剂、XO/URAT1双靶点抑制剂（痛风）、URAT1抑制剂等，覆盖糖尿病、减重、痛风等代谢内分泌领域。
从商业模式上看，通化东宝是一家典型的"自建专业化销售团队+学术推广+医药商业配送"的处方药企业。由于胰岛素产品的销售专业性极强，公司自建了专业的学术推广团队和商务团队，产品通过医药商业公司配送到医院和零售渠道。这种重销售、重渠道的模式，决定了它是一家"吃慢钱、吃长钱"的公司——一旦渠道铺开、产品进院，就是持续稳定的现金流，但也意味着销售费用长期高企。
2. 它凭什么活着：核心壁垒拆解
通化东宝能活三十多年，并且在集采血战里"摔而不倒"，靠的是几道实打实的护城河。
第一道壁垒：人胰岛素"国内第一"的存量地位与产能规模。
胰岛素是典型的"高壁垒、重资产、强监管"的生意。通化东宝是国内最早实现重组人胰岛素产业化的企业之一，它的"甘舒霖"系列人胰岛素，陪伴了几代中国糖尿病患者。43.7%的人胰岛素市占率、国内第一的地位，意味着它在最基础的糖尿病用药上，拥有庞大的患者基数和医生认知。这种存量地位，是几十年渠道、品牌、质量口碑积累出来的，不是后来者用钱能短时间砸出来的。
更重要的是产能。胰岛素生产需要大规模发酵、纯化、制剂灌装，通化东宝拥有国家级企业技术中心、国家GMP和欧盟GMP认证的生产车间。这种重资产产能，既是成本优势的来源，也是后来者难以逾越的门槛。
第二道壁垒：全线A/A1类集采中标换来的渠道覆盖。
2024年4月的胰岛素专项集采续标中，通化东宝全系列胰岛素产品以A类中选，其中甘精胰岛素、预混型门冬胰岛素以A1类中选。这意味着它拿到了首年采购需求量的90%甚至100%，以及全国集采二次分配量中30%以上的份额。签约量从首次集采的约2600万支，大幅增长到约4500万支。
集采给通化东宝带来的最大红利，不是利润，是进院数量。随着集采落地，通化东宝的胰岛素类似物在医院准入上实现巨大突破——甘精胰岛素新增准入约1400家医院，门冬胰岛素新增准入约3000家医院，预混型门冬胰岛素新增准入约5000家医院。这种覆盖全国、尤其深入基层的渠道网络，是它"以价换量"战略的根基。
第三道壁垒：中成药+多品类的"分散风险"结构。
很多人忽略了，通化东宝不只是一家胰岛素公司。它还有镇脑宁胶囊等中成药，以及恩格列净、西格列汀、瑞格列奈、依托考昔片等化药。这种"生物药+化学药+中成药"的多品类结构，让它在胰岛素集采冲击下，不至于"全军覆没"，有一定的风险分散能力。
第四道壁垒：海外注册的"先行者"地位。
通化东宝在出海这件事上，其实走得比很多人想象的早。它的利拉鲁肽注射液已经拿到包括尼加拉瓜在内的多个新兴市场国家的药品注册证书，人胰岛素原料药通过了欧盟EMA上市批准前的GMP检查，利拉鲁肽注射液获得了哥伦比亚GMP证书。这种海外注册能力的积累，是很多国产药企不具备的稀缺能力。
3. 财务真相：营收与利润的"剪刀差"
通化东宝这几年的财务曲线，是一幅剧烈的"过山车"图景。我们用最硬的数据还原真相。
营业收入与利润：从15.82亿到亏损再到12.19亿的剧烈波动。
年份
营业收入（亿元）
同比增速
归母净利润（亿元）
同比增速
扣非净利润（亿元）
2022
27.78
-
15.82
-
8.41
2023
30.75
+10.68%
11.68
-26.17%
11.68
2024
20.10
-34.66%
-0.43
-103.66%
-0.09
2025
29.47
+46.66%
12.19
扭亏为盈
约12.19
2026H1
15.53
+11.13%
2.96
+37.32%
-
数据来源：通化东宝2024年年度报告、2025年年度报告、2026年半年度报告及相关公告。
这张表里藏着几个关键真相，值得我们逐条拆开。
真相一：2022年的15.82亿净利，是集采前的"最后的辉煌"。
2022年是胰岛素专项集采落地前的最后一年（2022年5月首轮集采才开始执行），也是通化东宝业绩的历史高点——归母净利润15.82亿元。这个数字，后来成了它再也回不去的高点。
真相二：2024年的-0.43亿亏损，是三记重锤叠加的结果。
这是通化东宝上市以来第一次归母净利润亏损，也是本文最值得深挖的部分。亏损的原因，不是单一因素，而是"三记重锤"：
第一锤：集采降价+渠道库存补差。 2024年胰岛素集采续标，通化东宝各产品中标价格均有不同程度下降。更关键的是，集采降价带来了"价格下调预期"，商业客户纷纷控制库存、减少发货，导致2024年上半年国内胰岛素制剂销量仅1880万支，环比2023年下半年的4523万支减少2643万支，环比减少58%。同时，公司还对集采实施前流通环节的库存产品，按原供货价与集采价的差额进行一次性冲销或返还。据公司对上交所问询函的回复，价格变动导致收入减少约1.53亿元，销量波动导致收入减少约7.40亿元，合计导致利润总额减少约8.42亿元。
第二锤：终止双胰岛素项目THDB0207，计提巨额损失。 通化东宝决定终止可溶性甘精赖脯双胰岛素注射液（THDB0207，即BioChaperone Combo）的临床研究。这个项目是公司2018年从法国SA ADOCIA公司引进的，为此支付了预付商业化权利款25352.36万元。项目终止后，公司对该项目研发资本化金额6455.82万元全额计提资产减值准备，并将2.54亿元的预付权利款确认为损失。扣除所得税影响后，这两项合计减少2024年净利润约27036.95万元。
第三锤：商标侵权诉讼赔偿。 通化东宝的"长舒霖"甘精胰岛素，被甘李药业起诉侵害其"长秀霖"商标权。2025年2月终审判决，通化东宝赔偿甘李药业经济损失及维权开支共计6131.21万元。
这三记重锤，几乎把通化东宝2024年的利润"清零"甚至"砸穿"。
真相三：2025年的扭亏，是"以价换量"战略的集中兑现。
2025年，通化东宝营收29.47亿元，同比暴增46.66%，净利12.19亿元扭亏为盈。这一年发生了什么？核心是"量"的爆发——集采第二轮落地后，通化东宝以A/A1类中标的红利开始兑现，胰岛素类似物销量大增。2025年一季度，胰岛素类似物销量就大幅增长123%，其中门冬系列胰岛素销量同比增长超260%。以价换量的逻辑，在这一年彻底兑现。
真相四：经营现金流，是这家公司最硬的底。
抛开利润表上的剧烈波动，看真金白银：2024年经营现金流净额4.60亿元（虽有下滑但仍为正），2025年继续改善。通化东宝的分红也极其慷慨——现金分红连续多年在4亿元以上，累计分红超33亿元，分红金额占净利润比例超过50%。2025年度拟派发现金红利每股0.30元（含税）。这种持续、大额的分红能力，说明通化东宝的"造血能力"是真实且健康的——卖胰岛素收到的是真钱，不是纸面利润。
一句话总结财务真相： 通化东宝的财务，是一幅典型的"集采冲击—底部亏损—强势反转"图景。2024年的亏损是集采阵痛+研发翻车+诉讼赔偿的一次性集中释放，2025年的扭亏是"以价换量"战略的兑现。它的现金流和分红能力是真实健康的，但利润的波动性也暴露了它"单一赛道、重渠道"的脆弱性。
4. 管线/产品盘点：手里到底有什么牌
通化东宝的牌，分三副：已经打熟的"人胰岛素+胰岛素类似物基本盘"，正在开牌的"GLP-1第二曲线"，以及作为补充的"口服降糖药+痛风+中成药"。
已上市产品（现金牛基本盘）
人胰岛素系列（甘舒霖）是压舱石，市占率国内第一；胰岛素类似物（甘精、门冬系列）是正在放量的升级盘。2024年集采续标全线A/A1类中标后，门冬系列胰岛素2024年下半年销量同比增长超300%，胰岛素类似物占公司总收入比例已接近40%。此外，利拉鲁肽注射液（GLP-1）、恩格列净片（SGLT-2）、磷酸西格列汀片（DPP-4）等新品已上市销售，瑞格列奈片、依托考昔片等也在放量。
在研管线（第二增长曲线）
这是通化东宝的"未来牌"，核心是围绕GLP-1和痛风两大方向：
司美格鲁肽注射液（THDB0225）——重磅GLP-1。 这是通化东宝布局的重磅产品，对标诺和诺德的"减重药王"司美格鲁肽。据公开信息，其中国III期临床试验已于2024年10月完成末例患者入组，进度处于国内前列。但需要注意的是，通化东宝的司美格鲁肽布局的是降糖适应症，未单独布局减重适应症。
德谷胰岛素利拉鲁肽注射液——全球首创复方。 这是全球首个上市的"胰岛素类似物+GLP-1受体激动剂"复方制剂，融合了两种药物的双组分优势。通化东宝在2025年3月完成III期临床试验首例受试者给药，属于国产进度领先的品种。这是通化东宝管线里技术含量较高、也较有看点的一张牌。
GLP-1/GIP双靶点受体激动剂（THDBH120）——减重创新药。 这是通化东宝在减重赛道真正押注的创新药，对标礼来的替尔泊肽（GLP-1/GIP双靶点）。2025年2月获得降糖和减重Ib期临床试验积极的顶线结果，减重适应症II期临床试验完成首例受试者给药。这是通化东宝管线里"含金量最高、也最不确定"的一张牌。
痛风赛道（XO/URAT1双靶点等）。 通化东宝把治疗领域从糖尿病拓展到了痛风等代谢疾病，布局了XO/URAT1双靶点抑制剂（THDBH151片，具有First-in-class潜力）、URAT1抑制剂（THDBH130片）等，其中多个项目IIa期临床试验达到主要终点。
管线盘点小结： 通化东宝的牌面，是一个"基本盘稳、但创新成色参差"的结构。人胰岛素+胰岛素类似物是现金牛，GLP-1赛道（利拉鲁肽、司美格鲁肽、德谷利拉、双靶点）是第二曲线，痛风赛道是补充。但需要客观指出的是，通化东宝的GLP-1管线里，利拉鲁肽和司美格鲁肽都是"类似药"（生物类似药/仿制药性质），真正的创新药（双靶点THDBH120）还处在早期阶段，尚未形成明确的临床数据优势。
这里还要补一个重要的观察维度：通化东宝的研发体系，呈现出鲜明的"产业化强、源头创新弱"的特征。从公开信息看，它的研发架构是"四地联动"——上海隆棵负责前沿技术孵化、杭州紫星负责管线转化与早期临床、北京中心负责临床注册申报、通化总部负责产业化量产落地。这套体系的优势在于全链条无职能重叠、转化效率高，但短板也极其明显：最上游的"原创研发环节"是缺失的。换句话说，通化东宝擅长的是把别人发明出来的分子，快速、低成本、高质量地做出来卖出去，而不是自己从零发明一个新分子。这种"制造型药企"的基因，决定了它在需要"源头创新"的GLP-1减重、First-in-class创新药赛道上，天然处于劣势，只能靠"引进"来补短板——而引进的风险，双胰岛素THDB0207已经用2.54亿元的代价给全市场上了生动的一课。
5. 关键交易与资本动作：钱和资源的流向
通化东宝近两年的资本动作，透露出这家老牌药企在转型期的挣扎与取舍。
动作一：回购+增持，管理层和控股股东"自证信心"。
2024年，通化东宝先后完成两期股份回购，合计回购约3827万股、金额约3亿元，占总股本1.95%，分别用于股权激励和注销。同时，控股股东东宝实业集团及董事长完成了首期增持，合计增持1053万股、金额8149万元。2025年10月起，公司又启动新一轮回购，累计回购300万股、金额2757万元。这种"回购+增持"的组合拳，是管理层在市场信心低迷时传递的信号。
动作二：控股股东高比例质押——最扎眼的隐忧。
这是通化东宝最需要警惕的一点。据2025年1月公告，控股股东东宝集团及其一致行动人合计持股6.22亿股，其中累计质押5.59亿股，占其所持股份的89.97%，占公司总股本的28.55%；其中东宝集团自身持股约6亿股，质押比例高达93.25%。如此高的质押比例，意味着一旦股价大幅下跌，可能触发质押风险，进而引发控股权变动的风险。这是悬在通化东宝头上的一把达摩克利斯之剑。
动作三：从法国ADOCIA引进双胰岛素项目——一次"翻车"的教训。
2018年，通化东宝从法国SA ADOCIA公司引进了可溶性甘精赖脯双胰岛素注射液（THDB0207）项目，并为此支付了2.54亿元的预付商业化权利款。这个项目最终在2024年被终止，2.54亿元打水漂。这个案例，是通化东宝"源头创新弱、依赖外部引进"的缩影——它引以为傲的产业化能力很强，但在最上游的分子设计、原创专利上，却常常要依赖外部。
动作四：参股君合盟——向合成生物"投石问路"。
2024年5月，通化东宝以自有资金1亿元增资君合盟生物制药（杭州），取得8.6759%的股权。君合盟是一家专注重组蛋白创新药物和合成生物学的企业，主要在研产品包括重组A型肉毒毒素、重组I/III型人胶原蛋白、重组人生长激素等。这笔投资，是通化东宝向"合成生物学"这一前沿方向的一次战略性试水。
动作五：出海——从"胰岛素"到"GLP-1"的步步为营。
通化东宝的出海，走的是"新兴市场先行的务实路线"。人胰岛素30R在乌兹别克斯坦获批上市，人胰岛素原料药通过欧盟GMP检查，利拉鲁肽注射液拿到哥伦比亚GMP证书、埃及GMP审计，以及尼加拉瓜等多个新兴市场国家的注册证书。截至2024年，通化东宝已实现海外收入1.03亿元，同比增长近80%，利拉鲁肽在海外17个新兴市场国家布局注册。这种"农村包围城市"的出海策略，虽然不像甘李授权美纳里尼那样"一单爆赚"，但胜在扎实、可持续。
资本动作小结： 通化东宝的钱和资源，正在沿着"回购增持稳信心→聚焦胰岛素+GLP-1主线→新兴市场出海→参股合成生物试水"的路径流动。这是一个老牌药企在转型期典型的"稳字当头、步步为营"的打法，但也暴露了它"源头创新靠外部、控股股东高质押"的软肋。
6. 风险与隐忧：客观泼冷水
写到这里，笔者必须放下"胰岛素双雄"的滤镜，客观地给通化东宝泼几盆冷水。
风险一：控股股东高比例质押——最大的悬顶之剑。
这是通化东宝最需要警惕的风险。控股股东东宝集团质押比例一度高达93.25%，虽然公司解释称东宝集团资产负债率较高、营收水平不够高、投资项目占用资金等，但如此高的质押比例，本质上暴露的是控股股东自身的资金链紧张。一旦通化东宝股价持续下跌，触及质押平仓线，可能引发连锁反应，甚至动摇控股权。这是所有关注通化东宝的投资者都必须正视的问题。
风险二："源头创新弱、依赖外部引进"的基因短板。
通化东宝的产业化能力是顶级的——它能把胰岛素做到国内第一、市占率43.7%，能把利拉鲁肽从菌株到制剂全链条自主落地。但它的"源头创新能力"是短板：最核心的双胰岛素项目THDB0207是从法国ADOCIA引进的，最后还翻了车（损失2.54亿）；司美格鲁肽、德谷胰岛素等分子，也多带有"类似药/复方"的性质，缺乏真正意义上First-in-class的原创分子。在一个越来越看重"源头创新"的医药时代，这个短板会越来越致命。
风险三：GLP-1减重赛道的"红海绞杀"与"适应症错位"。
通化东宝的GLP-1布局，存在一个微妙的"错位"：它最接近上市的司美格鲁肽、利拉鲁肽，布局的都是降糖适应症，而没有布局减重适应症（这是当下GLP-1最大的市场红利所在）。而真正布局减重的GLP-1/GIP双靶点THDBH120，还处在II期早期阶段。这意味着，通化东宝很可能"错过减重赛道最肥的一波红利"——等它的减重创新药做出来，GLP-1减重赛道可能已经是一片比现在更惨烈的红海，诺和诺德、礼来、以及国内信达、恒瑞等一众玩家早已杀成血海。
风险四：利润波动性大，业绩"过山车"风险仍在。
2024年的亏损已经证明，通化东宝的业绩对"集采政策"和"研发项目成败"高度敏感。集采已经进入常态化、多轮化，未来胰岛素价格仍有进一步下降的可能；而研发项目（尤其是引进项目）的失败风险，会时不时地"暴雷"。这种高波动性，意味着通化东宝不是一个可以"闭眼持有"的标的。
风险五：商标纠纷暴露的同业"内耗"。
通化东宝与甘李药业之间的"长舒霖/长秀霖"商标纠纷，最终以通化东宝赔偿6131万元告终。这背后，是"胰岛素双雄"本是同根生、却反目成仇的复杂历史。这种同业之间的内耗，不仅耗费了真金白银，也分散了管理层精力。
风险小结： 通化东宝不是一家可以"闭眼买"的公司。它的人胰岛素基本盘稳健、现金流健康，但控股股东高质押、源头创新弱、GLP-1减重布局错位、利润波动大，这些都是实实在在的硬伤。投资者需要用更挑剔的眼光，去审视这家"老牌胰岛素龙头"的真实成色。
7. 它值不值得长期关注：独立判断
笔者给出明确的立场：通化东宝值得长期关注，但现阶段"观察"的权重高于"看多"，更不构成"看空"。
看多的理由，是硬的：
第一，基本盘是真的稳。 人胰岛素市占率43.7%、国内第一，胰岛素类似物全线A/A1类集采中标、签约量4500万支，加上多品类的分散结构，让通化东宝在胰岛素这个刚需赛道上，有足够的"压舱石"。
第二，现金流和分红是真的好。 连续多年4亿元以上的现金分红、累计超33亿元、分红比例超50%，这是这家老牌药企最诚实的底。一家能持续产生强劲现金流、又坚持高比例分红的公司，长期不会差到哪去。
第三，GLP-1第二曲线已经"在路上"。 利拉鲁肽卖到了17个海外国家，德谷胰岛素利拉鲁肽复方国产进度领先，司美格鲁肽III期完成入组，GLP-1/GIP双靶点进入II期。这条管线虽然创新成色参差，但方向正确、步步推进。
但"观察"的理由，同样硬：
第一，控股股东高质押是绕不开的坎。 这是笔者对通化东宝最大的顾虑。在控股股东质押风险没有实质化解之前，任何"看多"都要打个问号。
第二，GLP-1减重布局错位，可能错过最大红利。 通化东宝最接近上市的GLP-1产品是"降糖"适应症，而"减重"这个最大的市场红利，它的创新药还太早。这种错位，可能让它在减重赛道"起了个大早、赶了个晚集"。
第三，利润波动性大，业绩"过山车"风险仍在。 2024年的亏损已经敲响警钟，未来集采降价、研发翻车的风险依然存在。
结论： 通化东宝是一家"基本盘稳、弹性看GLP-1、隐忧在质押"的公司。如果你看重它的现金流、分红和人胰岛素龙头地位，可以保持关注；如果你在意控股股东质押风险和GLP-1减重布局错位，就再等等。笔者的态度是：把通化东宝放进观察清单，盯住三个变量——控股股东质押风险的化解进展、德谷胰岛素利拉鲁肽复方的上市进度、GLP-1/GIP双靶点THDBH120的II期数据。 这三个变量，决定了通化东宝的转型是"老树发新芽"还是"温水煮青蛙"。
8. 几个值得深挖的背景线索
线索一：李一奎——一个把名字刻进中国胰岛素产业史的男人。
通化东宝的创始人李一奎，是中国胰岛素产业绕不开的名字。他早年与甘忠如合作，一个出技术（甘忠如）、一个出资金和资源（李一奎），共同孵化了甘李药业——"甘李"二字，就是甘忠如的"甘"加上李一奎的"李"。后来，两人分道扬镳：甘忠如带着甘李药业，主攻三代胰岛素类似物，做成了"国产三代胰岛素领头羊"；李一奎守着通化东宝，主攻二代人胰岛素，做成了"国产二代胰岛素老大哥"。这两家"本是同根生"的公司，如今在集采的战场上正面交锋，还打了一场"长舒霖/长秀霖"的商标官司。这段恩怨，本身就是中国胰岛素产业从无到有、从跟跑到并跑的一部缩影。
线索二："甘李"分家——中国胰岛素双雄的宿命对决。
通化东宝和甘李药业，是中国胰岛素市场最经典的"双雄"叙事。一个主攻人胰岛素（二代），一个主攻胰岛素类似物（三代），曾经是错位竞争、井水不犯河水。但近年来，随着两家都开始向对方的地盘渗透——通化东宝上马胰岛素类似物、甘李也布局人胰岛素——两者越来越短兵相接。2026年上半年，甘李营收22.23亿元（+7.56%）、净利6.09亿元（+0.94%），通化东宝营收15.53亿元（+11.13%）、净利2.96亿元（+37.32%）。"胰岛素双雄"的对比，本身就是中国糖尿病用药格局变迁的一面镜子：甘李胜在"技术代差"，通化东宝胜在"存量规模"。
线索三：胰岛素集采——一场改变中国糖尿病用药格局的"国运之战"。
胰岛素是中国第一个被纳入国家集采的生物药。集采前，中国胰岛素市场被诺和诺德、赛诺菲、礼来三家外资垄断，国产份额不足20%，价格高昂。两轮集采后，国产胰岛素份额大幅提升，三代胰岛素使用量占比从58%提升到70%，通化东宝、甘李等国产企业借机完成了对基层市场的渗透。这场集采，本质上是国家用"以价换量"的杠杆，撬动了一次国产胰岛素对进口品牌的"国运级"替代。通化东宝是这场替代的重要参与者，但它也付出了2024年亏损的代价。这一课，值得所有关注中国医药政策的人反复咀嚼。
线索四：双胰岛素THDB0207——一次"引进翻车"的深刻教训。
通化东宝2018年从法国ADOCIA公司引进的双胰岛素项目THDB0207，最终在2024年终止，2.54亿元预付权利款打了水漂。这个案例，是国产药企"license-in（引进）"模式的一个经典反面教材——引进了海外分子的中国权益，但分子本身的研发风险和临床不确定性，最终还是得自己扛。通化东宝的"产业化强、源头创新弱"，正是它一次次在"引进"上栽跟头的根源。这给所有"重引进、轻原创"的药企提了个醒。
线索五：东北药企的"通化帮"。
通化，这个地处长白山麓、吉林省东南部的小城，却是中国医药产业一个特殊的存在——这里孕育了通化东宝、通化金马、紫鑫药业等一批药企，形成了独特的"通化医药帮"。通化东宝作为其中资格最老、体量最大的代表，见证了中国东北医药产业的兴衰。它的命运，某种程度上也是东北民营药企转型困境的一个缩影：守着传统赛道的老本，艰难追赶创新药的时代浪潮。
9. 深度补充：把两个关键问题彻底讲透
问题一：通化东宝的"人胰岛素龙头"地位，在"三代胰岛素"时代还值钱吗？
这是理解通化东宝价值的核心问题。要讲透它，得先说清胰岛素的"代际"逻辑。
胰岛素分三代：第一代是动物胰岛素（从猪、牛胰脏提取），第二代是人胰岛素（基因工程重组技术生产，氨基酸序列与人胰岛素完全一致），第三代是胰岛素类似物（在人胰岛素基础上改造氨基酸序列，使起效更快或更平稳）。从临床价值看，三代胰岛素类似物相比二代人胰岛素，有更符合生理的分泌曲线、更低的低血糖风险，是当前的主流方向。中国的胰岛素市场，也正在经历从"二代"向"三代"的迁移——三代胰岛素使用量占比已从集采前的58%提升到70%。
那么，通化东宝赖以起家的"人胰岛素（二代）"龙头地位，在"三代"时代还值钱吗？笔者的判断是："存量"值钱，"增量"缩水。
"存量值钱"的逻辑在于：中国有大量基层糖尿病患者，他们对价格敏感，人胰岛素作为最基础、最便宜的胰岛素，在基层市场依然有庞大的刚性需求。通化东宝43.7%的人胰岛素市占率，意味着它锁定了这个最大的存量市场，这是它的"现金牛"。
"增量缩水"的逻辑在于：随着三代胰岛素类似物集采降价、以及医保覆盖，越来越多的患者会从"二代"升级到"三代"。人胰岛素的增量市场，正在被胰岛素类似物蚕食。这就是为什么通化东宝要拼命上马甘精、门冬等胰岛素类似物——它必须在新旧代际的切换中，守住自己的份额。
所以，通化东宝的"人胰岛素龙头"地位，是一块"值钱但在缩水"的蛋糕。它真正的未来，取决于两件事：一是能否在胰岛素类似物上复制它在人胰岛素上的成功（目前看，门冬系列放量很快，有戏）；二是能否在GLP-1这个"下一代"赛道上卡位成功（目前看，减重布局偏晚，存疑）。
问题二：GLP-1会不会"颠覆"胰岛素？通化东宝的"第二曲线"到底成色如何？
这是理解通化东宝未来价值的另一个核心问题。
GLP-1（胰高血糖素样肽-1）受体激动剂，是近年来最火的代谢疾病靶点。它的作用远不止降血糖：能促进胰岛素分泌、抑制胰高血糖素分泌、延缓胃排空、抑制食欲——尤其是最后两点，让它从"降糖药"进化成了"减重药"，催生了司美格鲁肽、替尔泊肽这样的"药王"级产品。
那么，GLP-1会不会"颠覆"胰岛素？笔者的判断是：GLP-1会重塑代谢疾病的治疗格局，但不会完全取代胰岛素。 两者解决的是糖尿病治疗中的不同问题——胰岛素是"外源补充"（直接给身体补充胰岛素），GLP-1是"内源调控"（激活身体自身的胰岛素分泌并抑制食欲）。对于1型糖尿病和部分胰岛素分泌功能衰竭的2型糖尿病患者，胰岛素依然是不可替代的救命药。GLP-1更多是在2型糖尿病早期、以及肥胖/超重人群中，提供一种"治本"的选择。
所以，通化东宝"胰岛素基本盘+GLP-1第二曲线"的双轮战略，方向是对的。但它的GLP-1第二曲线"成色如何"，要打一个问号：
成色不足的地方在于"适应症错位"。 通化东宝最接近上市的GLP-1产品（利拉鲁肽已上市、司美格鲁肽III期完成入组），布局的都是降糖适应症。而降糖适应症的GLP-1，面临的是胰岛素、DPP-4、SGLT-2等众多成熟降糖药的竞争，市场空间和商业价值，远不如"减重适应症"（这是当下GLP-1最大的红利所在）。通化东宝真正布局减重的GLP-1/GIP双靶点THDBH120，还处在II期早期，等到它做出来，减重赛道可能已经红海泛滥。
成色尚可的地方在于"德谷胰岛素利拉鲁肽复方"。 这款"胰岛素+GLP-1"的复方制剂，是通化东宝管线里较有差异化的一张牌。它融合了胰岛素的降糖和GLP-1的减重/减副作用优势，国产进度领先。如果它能顺利上市，可能成为通化东宝在"胰岛素+GLP-1"交叉地带的一个特色产品。
笔者的判断： 通化东宝的GLP-1第二曲线，方向正确、但节奏偏慢、且存在"降糖错位"的软肋。它最现实的看点，是"胰岛素类似物放量+德谷利拉复方上市"这条"稳中求进"的路径，而不是押注减重创新药的"大开大合"。投资者应该把期望值放平——通化东宝的转型，是一场"守正出奇"的持久战，而不是"毕其功于一役"的豪赌。
最后，还要点破一个更深层的逻辑：通化东宝和甘李药业这对"胰岛素双雄"，其实代表了两种截然不同的转型路径。甘李走的是"技术代差"路线——用一款真正的创新药（双周一次GLP-1博凡格鲁肽）去撬动海外授权、撬动估值重估，虽然利润成色有瑕疵，但故事性感、想象空间大；通化东宝走的是"存量深耕"路线——守住人胰岛素的现金流基本盘，用胰岛素类似物和复方制剂稳扎稳打地升级，虽然扎实、稳健，但缺少一款能点燃市场的"爆点产品"，故事平淡、估值缺乏弹性。这两种路径没有绝对的高下之分，但对投资者来说，意味着完全不同的持有体验：买甘李，买的是"赌性"和"弹性"；买通化东宝，买的是"确定性"和"分红"。想清楚自己到底在买什么，比纠结哪家更好，更重要。
10. 数据出处与参考文献
1. 通化东宝药业股份有限公司2024年年度报告，上海证券交易所，2025年4月30日。
2. 通化东宝药业股份有限公司2025年年度报告，上海证券交易所，2026年4月19日。
3. 通化东宝药业股份有限公司2026年半年度报告，上海证券交易所，2026年8月25日。
4. 通化东宝药业股份有限公司关于研发项目终止暨计提资产减值准备的公告，2026年8月25日。
5. 通化东宝关于上海证券交易所对公司2024年年度报告的信息披露监管问询函的回复公告（公告编号：2025-047），2025年7月12日。
6. 证券时报·e公司《通化东宝2025年实现净利润12.19亿元，同比实现扭亏为盈》，孙宪超，2026年4月19日。
7. 证券时报·e公司《胰岛素双雄半年报：拓展海外市场 加码管线研发》，孙宪超，2026年8月25日。
8. 人民财讯《通化东宝：上半年净利润2.96亿元，同比增长37.32%》，司迪，2026年8月24日。
9. 通化东宝官网《通化东宝：2025年一季度收入恢复双位数增长，胰岛素类似物销量大增123%》，2025年4月30日。
10. 财联社《业绩颓势延续 通化东宝Q3销售费用超3亿元》，何凡，2024年10月24日。
11. 北京商报《净利大降九成 胰岛素龙头失速》，丁宁，2025年1月22日。
12. 证券时报·e公司《通化东宝2024年净利预减逾9成 推进创新药研发》，2025年1月20日。
13. 证券时报《沪市胰岛素龙头齐发利好 "集采红利+出海破局"双轮驱动》，陈雨康，2026年3月4日。
14. 通化东宝关于利拉鲁肽注射液获境外药品注册证书的公告，2026年5月25日。
（注：本文所引财务数据均来自公司公开披露的定期报告与公告；部分行业背景与赛道判断综合自公开研报与媒体报道，观点部分为笔者独立判断，已明确标注。）
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*免责声明：本文为独立研究观察，所引用数据均来自公开渠道，观点仅代表笔者个人判断，不构成任何投资建议。医药行业研发与商业化存在高度不确定性，投资者应独立决策、自担风险。*
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 2型糖尿病 | 美国 | 2006-10-16 | |
| 2型糖尿病 | 美国 | 2006-10-16 |
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 炎症 | 临床3期 | 加拿大 | 2015-08-01 | |
| 低血糖 | 临床3期 | - | 2010-06-22 | |
| 高脂血症 | 临床3期 | 加拿大 | 2008-02-01 | |
| 终末期肾脏病 | 临床3期 | - | 2007-10-19 | |
| 妊娠期糖尿病 | 临床2期 | 意大利 | 2011-05-01 | |
| 胰岛素抵抗 | 临床2期 | 意大利 | 2011-05-01 | |
| 糖尿病前期 | 临床2期 | 意大利 | 2011-05-01 | |
| 2型糖尿病肾脏病 | 临床2期 | 美国 | 2009-06-05 | |
| 葡萄糖耐受不良 | 临床2期 | 美国 | 2009-03-01 | |
| 心脏衰竭 | 临床1期 | 美国 | 2008-04-01 |
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| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
N/A | 2,290 | 範鏇醖獵鏇網廠獵艱衊(鏇鏇願遞製遞鹹淵餘願) = 艱窪醖顧淵顧製願製鏇 艱鬱網願艱網齋鹹窪築 (窪鏇餘築鬱糧繭鬱顧窪 ) 更多 | 积极 | 2026-06-20 | |||
範鏇醖獵鏇網廠獵艱衊(鏇鏇願遞製遞鹹淵餘願) = 製淵獵窪獵廠鏇願願獵 艱鬱網願艱網齋鹹窪築 (窪鏇餘築鬱糧繭鬱顧窪 ) | |||||||
临床2期 | 12 | 艱範襯糧選窪鏇蓋壓膚(壓鹹鹹繭獵製鏇製鹽鏇): P-Value = 0.008 更多 | 积极 | 2026-05-29 | |||
临床2期 | 48 | 鏇壓餘糧積構遞遞顧憲(鑰艱積築窪遞鬱獵選醖) = 壓糧廠鬱齋糧蓋艱築鬱 憲齋蓋廠齋憲製繭夢願 (願願壓構築餘窪鹹糧簾 ) 更多 | 积极 | 2026-05-29 | |||
临床3期 | 7,850 | (Glargine Insulin U-100) | 壓膚構齋艱製糧憲鬱顧(襯繭製築鹽廠廠餘醖構) = 鹽醖夢願餘積蓋糧鑰遞 製壓鑰選簾選淵夢醖選 (網構憲製鬱遞膚蓋製選, 膚蓋顧醖窪選糧鹹廠繭 ~ 壓簾遞淵繭鹽遞簾齋艱) 更多 | - | 2026-02-10 | ||
(Glimepiride) | 壓膚構齋艱製糧憲鬱顧(襯繭製築鹽廠廠餘醖構) = 襯築鹹窪觸觸選構選願 製壓鑰選簾選淵夢醖選 (網構憲製鬱遞膚蓋製選, 齋鹹選願範獵鹽顧選顧 ~ 廠鏇膚鹽壓醖鹽築夢鑰) 更多 | ||||||
临床4期 | 18 | (Sitagliptin Group) | 網齋壓簾鑰獵鬱窪鏇遞(積壓淵網觸選窪壓艱簾) = 艱膚膚築壓壓製壓積壓 遞鹽遞窪膚壓餘範鹽繭 (遞選選遞壓膚憲築網觸, 製積簾夢膚鑰糧夢壓積 ~ 觸蓋遞鑰簾網餘鬱艱鬱) 更多 | - | 2026-01-28 | ||
(Dapagliflozin Group) | 網齋壓簾鑰獵鬱窪鏇遞(積壓淵網觸選窪壓艱簾) = 築構顧顧夢簾積鏇淵願 遞鹽遞窪膚壓餘範鹽繭 (遞選選遞壓膚憲築網觸, 膚簾鏇鏇糧鑰鑰繭鏇艱 ~ 糧窪鏇構願簾範廠鏇積) 更多 | ||||||
临床3期 | 132 | 鬱遞顧憲繭醖壓餘繭糧(壓積遞遞蓋衊範繭襯鑰): Difference = 0.11 (95.0% CI, 0.03 ~ 0.19), P-Value = 0.0063 更多 | 积极 | 2025-10-14 | |||
Placebo | |||||||
临床4期 | 4 | (LCZ696) | 鹹遞獵範鹹築艱觸選醖(夢膚鹽蓋鏇築夢鏇壓壓) = 遞鏇糧觸衊醖遞鑰顧醖 醖膚夢憲顧醖選製艱獵 (廠鹹獵齋膚艱醖顧製築, 鹹構夢觸網製膚齋築餘 ~ 簾構遞憲網鑰鹽網鏇獵) | - | 2025-08-03 | ||
(Valsartan) | 鹹遞獵範鹹築艱觸選醖(夢膚鹽蓋鏇築夢鏇壓壓) = 餘網遞衊廠蓋蓋衊餘艱 醖膚夢憲顧醖選製艱獵 (廠鹹獵齋膚艱醖顧製築, 鹹壓餘遞淵簾鬱襯願餘 ~ 繭鹽積蓋夢窪願艱遞窪) 更多 | ||||||
临床4期 | 701 | 獵鹹願繭壓繭齋遞膚網(鏇膚範衊餘觸願糧齋鹹) = 糧製範醖鹹鑰衊壓鹹鑰 壓鏇蓋淵繭構窪膚網蓋 (憲夢憲鏇範獵衊鑰簾構 ) 更多 | 积极 | 2025-05-05 | |||
Metformin combined with Sitagliptin 100 mg | 獵鹹願繭壓繭齋遞膚網(鏇膚範衊餘觸願糧齋鹹) = 範築構糧構醖獵鏇鹽製 壓鏇蓋淵繭構窪膚網蓋 (憲夢憲鏇範獵衊鑰簾構 ) 更多 | ||||||
临床3期 | - | 製壓壓獵願構遞廠夢憲(膚顧鹹艱膚齋範鹹選衊) = 膚願鏇膚蓋範膚鹹醖繭 糧範艱鑰構醖廠鑰願淵 (糧觸積選膚鑰網鬱簾糧 ) 更多 | 积极 | 2024-11-15 | |||
製壓壓獵願構遞廠夢憲(膚顧鹹艱膚齋範鹹選衊) = 繭糧繭襯製選構廠蓋夢 糧範艱鑰構醖廠鑰願淵 (糧觸積選膚鑰網鬱簾糧 ) 更多 | |||||||
临床3期 | 4,098 | 齋製構窪蓋製廠網顧選(夢遞觸壓築齋範餘網製) = 獵觸窪膚壓糧壓積選壓 鹽窪積淵衊餘廠憲憲襯 (觸蓋簾製淵衊鏇衊鬱醖 ) | 积极 | 2024-03-01 | |||
齋製構窪蓋製廠網顧選(夢遞觸壓築齋範餘網製) = 壓蓋淵顧獵鬱願築廠築 鹽窪積淵衊餘廠憲憲襯 (觸蓋簾製淵衊鏇衊鬱醖 ) |
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