预约演示
更新于：2026-05-07
Canagliflozin Hemihydrate
卡格列净
更新于：2026-05-07
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 美国 (2013-03-29), |
最高研发阶段(中国)批准上市 |
特殊审评优先审评 (中国) |
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结构/序列
分子式C48H52F2O11S2 |
InChIKeyVHOFTEAWFCUTOS-TUGBYPPCSA-N |
CAS号928672-86-0 |
关联
218
项与 卡格列净 相关的临床试验CTIS2026-525944-14-00
Bioequivalence clinical trial of two formulations of canagliflozin
开始日期2026-06-15 |
申办/合作机构- |
NCT07527390
CANagliflozin In DIALysis Patients
Rationale:
Sodium glucose co-transporter 2 (SGLT2) inhibitors are a relatively new class of drugs originally developed for the treatment of diabetes. Cardiovascular outcome trials with these drugs showed also beneficial effects of these agents on heart failure, cardiovascular disease and kidney outcomes. Secondary analyses from these trials demonstrated that these benefits were consistent in patients with or without type 2 diabetes and with or without chronic kidney disease (CKD) with a lower eGFR threshold of 20 mL/min/1.73m2. However, it is not yet clear if these drugs can also be used in patients with severe kidney disease who require dialysis. This is in part explained because SGLT2 inhibitors bind to a transporter which is located in the luminal side of proximal tubes in the kidney. If kidney function is low, and these patients have no or limited filtering capacity, it is possible that the efficacy of these drugs decrease. Notwithstanding, several animal experiments and preliminary clinical data have suggested that these drugs do have kidney and cardiac protective effects in case of severely decreased kidney function.
The investigators hypothesize that SGLT2 inhibitors are distributed to several tissues in the body on top of the kidney and therefore the investigators would like to investigate the specific tissue distribution of SGLT2 inhibitors in patients on dialysis with-and without residual diuresis.
Sodium glucose co-transporter 2 (SGLT2) inhibitors are a relatively new class of drugs originally developed for the treatment of diabetes. Cardiovascular outcome trials with these drugs showed also beneficial effects of these agents on heart failure, cardiovascular disease and kidney outcomes. Secondary analyses from these trials demonstrated that these benefits were consistent in patients with or without type 2 diabetes and with or without chronic kidney disease (CKD) with a lower eGFR threshold of 20 mL/min/1.73m2. However, it is not yet clear if these drugs can also be used in patients with severe kidney disease who require dialysis. This is in part explained because SGLT2 inhibitors bind to a transporter which is located in the luminal side of proximal tubes in the kidney. If kidney function is low, and these patients have no or limited filtering capacity, it is possible that the efficacy of these drugs decrease. Notwithstanding, several animal experiments and preliminary clinical data have suggested that these drugs do have kidney and cardiac protective effects in case of severely decreased kidney function.
The investigators hypothesize that SGLT2 inhibitors are distributed to several tissues in the body on top of the kidney and therefore the investigators would like to investigate the specific tissue distribution of SGLT2 inhibitors in patients on dialysis with-and without residual diuresis.
开始日期2026-06-01 |
申办/合作机构- |
NCT06858436
The Role of SGLT2 Inhibitors in Stroke-reperfusion Injury:A Multi-Center, Randomized, Open-Label, Controlled Trial
Background:
Reperfusion therapies, including intravenous rt-PA and mechanical thrombectomy, significantly improve outcomes in acute ischemic stroke. However, these interventions also increase the risk of hemorrhagic transformation and malignant edema. Preclinical studies have demonstrated that Canagliflozin, an SGLT2 inhibitor, reduces astrocyte swelling and brain edema in a transient middle cerebral artery occlusion (tMCAo) model. While SGLT2 inhibitors have shown neuroprotective effects in the acute phase of ischemic stroke, their potential to mitigate hemorrhagic transformation and malignant edema following reperfusion therapy in humans remains unexamined.
Aims:
This study aims to evaluate the effect of SGLT2 inhibitors on hemorrhagic transformation and malignant edema in patients undergoing reperfusion therapy for acute ischemic stroke.
Methods:
This is a multi-center, randomized, open-label, controlled study enrolling ischemic stroke patients aged 18 years or older who meet predefined inclusion and exclusion criteria. Participants will be randomized to receive Canagliflozin 100 mg once daily for 14 days or no additional treatment before undergoing mechanical thrombectomy. Clinical data collection will include baseline demographics, medical and medication history, NIHSS scores at admission and 24 hours post-reperfusion, stroke subtype, modified Thrombolysis in Cerebral Infarction (TICI) scores, laboratory results, and modified Rankin Scale (mRS) scores at discharge and 3 months post-stroke.
The primary outcome is to assess the association between Canagliflozin use and the severity of hemorrhagic transformation and malignant edema. Hemorrhagic transformation will be classified using the Heidelberg criteria, and malignant edema will be defined as a midline shift of ≥5 mm. Brain imaging, including CT scans at 24 hours post-intervention and additional scans as clinically indicated, will be reviewed by blinded radiologists. Brain MRA will also be performed to assess infarct size and edema progression.
Importance:
This study aims to explore the potential for repurposing SGLT2 inhibitors as a therapeutic strategy in acute ischemic stroke. If Canagliflozin is shown to reduce hemorrhagic transformation and malignant edema, it could offer a novel adjunctive treatment to improve patient outcomes following reperfusion therapy.
Reperfusion therapies, including intravenous rt-PA and mechanical thrombectomy, significantly improve outcomes in acute ischemic stroke. However, these interventions also increase the risk of hemorrhagic transformation and malignant edema. Preclinical studies have demonstrated that Canagliflozin, an SGLT2 inhibitor, reduces astrocyte swelling and brain edema in a transient middle cerebral artery occlusion (tMCAo) model. While SGLT2 inhibitors have shown neuroprotective effects in the acute phase of ischemic stroke, their potential to mitigate hemorrhagic transformation and malignant edema following reperfusion therapy in humans remains unexamined.
Aims:
This study aims to evaluate the effect of SGLT2 inhibitors on hemorrhagic transformation and malignant edema in patients undergoing reperfusion therapy for acute ischemic stroke.
Methods:
This is a multi-center, randomized, open-label, controlled study enrolling ischemic stroke patients aged 18 years or older who meet predefined inclusion and exclusion criteria. Participants will be randomized to receive Canagliflozin 100 mg once daily for 14 days or no additional treatment before undergoing mechanical thrombectomy. Clinical data collection will include baseline demographics, medical and medication history, NIHSS scores at admission and 24 hours post-reperfusion, stroke subtype, modified Thrombolysis in Cerebral Infarction (TICI) scores, laboratory results, and modified Rankin Scale (mRS) scores at discharge and 3 months post-stroke.
The primary outcome is to assess the association between Canagliflozin use and the severity of hemorrhagic transformation and malignant edema. Hemorrhagic transformation will be classified using the Heidelberg criteria, and malignant edema will be defined as a midline shift of ≥5 mm. Brain imaging, including CT scans at 24 hours post-intervention and additional scans as clinically indicated, will be reviewed by blinded radiologists. Brain MRA will also be performed to assess infarct size and edema progression.
Importance:
This study aims to explore the potential for repurposing SGLT2 inhibitors as a therapeutic strategy in acute ischemic stroke. If Canagliflozin is shown to reduce hemorrhagic transformation and malignant edema, it could offer a novel adjunctive treatment to improve patient outcomes following reperfusion therapy.
开始日期2026-04-13 |
申办/合作机构 |
100 项与 卡格列净 相关的临床结果
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100 项与 卡格列净 相关的转化医学
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100 项与 卡格列净 相关的专利（医药）
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1,811
项与 卡格列净 相关的文献（医药）2026-07-01·JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
Canagliflozin alleviates hyperandrogen-induced granulosa cell ferroptosis in polycystic ovary syndrome mice by activating the AMPK/GSK3β/NRF2 pathway
Article
作者: Liu, Yilin ; Lin, Jindan ; Wang, Yujing ; Zhang, Zhiying ; Cheng, Weilun ; Yan, Shuang ; Qi, Yanfei ; Zhou, Weiyu ; Yu, Haiqiao
Polycystic ovary syndrome (PCOS) is a common metabolic disorder affecting women of reproductive age. Clinical evidence suggests that the SGLT2 inhibitor canagliflozin has potential therapeutic effects in PCOS; however, its mechanisms remain unclear. The hyperandrogenic state in patients with PCOS leads to disrupted iron metabolism and oxidative stress. Herein, we aimed to investigate whether canagliflozin ameliorates PCOS symptoms by reducing oxidative stress and inhibiting granulosa cell ferroptosis, as well as to elucidate the underlying mechanisms. We found that canagliflozin treatment significantly restored the estrous cycle, improved polycystic ovarian morphology, reduced serum testosterone levels, and alleviated metabolic disorders, such as insulin resistance and dyslipidemia, in PCOS-like mice. Mechanistically, canagliflozin activated the AMPK/GSK3β pathway, promoted NRF2 nuclear translocation, upregulated GPX4, and ultimately inhibited lipid peroxidation and mitochondrial damage, thereby attenuating hyperandrogen-induced ferroptosis. These results reveal that canagliflozin exerts protective effects via the AMPK/GSK3β/NRF2 axis, thereby offering a potential alternative for PCOS treatment and identifying a promising drug target for clinical intervention.
2026-06-01·International journal of cardiology. Cardiovascular risk and prevention
Renal and cardiovascular effects of SGLT2 inhibitors among hypertensive patients with chronic kidney disease: A systematic review and meta-analysis
Review
作者: Danny, Siska Suridanda ; Kuncoro, Brm Ario Suryo ; Kosen, Yosua Darmadi ; Amalia, Fauqi ; Pintaningrum, Yusra ; Dharma, Ahmad Surya ; Javier, R Mohamad ; Faizin, Iqbal ; Fiohana, Puput ; Nurpradika, Brianka Yudha ; Firasghani, Muhammad Almy ; Kurniawan, Kristian ; Puspitasari, Renny Anggraeni ; Andiani ; Samudra, Dian
Background:
Chronic kidney disease (CKD) is frequently complicated by hypertension, a dual contributor to disease progression and cardiovascular risk. Despite standard therapy with renin-angiotensin-aldosterone system inhibitors, residual risk remains high. Sodium-glucose cotransporter-2 (SGLT2) inhibitors have emerged as a novel therapy with proven renal and cardiovascular benefits, but their effects in hypertensive CKD patients remain less well defined.
Methods:
We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) that evaluated SGLT2 inhibitors in CKD patients with baseline systolic blood pressure ≥140 mmHg or renovascular disease. PubMed, Embase, and Cochrane Library were searched from inception to August 2024. Eligible RCTs compared an SGLT2 inhibitor versus placebo and reported outcomes in hypertensive subgroups. Primary outcome was a composite of kidney failure, sustained decline in estimated glomerular filtration rate (eGFR ≥40-50 %), or cardiovascular death. Secondary outcomes included kidney-specific endpoints, cardiovascular composite outcomes, and serious adverse events (SAEs). Pooled odds ratios (ORs) were calculated using random-effects models.
Results:
Three RCTs were included: CREDENCE (canagliflozin), DAPA-CKD (dapagliflozin), and EMPA-KIDNEY (empagliflozin), encompassing 5436 hypertensive participants. For the primary outcome, SGLT2 inhibitors reduced risk compared with placebo (OR 0.76, 95 % CI 0.65-0.88). Kidney outcomes showed consistent benefit (OR 0.70, 95 % CI 0.58-0.85). Cardiovascular events were modestly reduced (OR 0.79, 95 % CI 0.64-0.97). SAEs were slightly lower with SGLT2 inhibitors (OR 0.85, 95 % CI 0.74-0.96). Overall certainty of evidence was graded as moderate.
Conclusions:
Among hypertensive patients with CKD, SGLT2 inhibitors significantly reduce renal disease progression and cardiovascular events while maintaining favorable safety. These findings support their integration into standard therapy for this high-risk population.
2026-05-01·Kidney International Reports
Cystatin C Confirms the Canagliflozin eGFR Slope Benefit in CANPIONE
Article
作者: Hatanaka, Takashi ; Sasaki, Motofumi ; Nakatou, Tatsuaki ; Miyamoto, Satoshi ; Fujimoto, Kei ; Miyatake, Nobuyuki ; Shikata, Kenichi ; Heerspink, Hiddo J L ; Toyoda, Masao ; Kitada, Munehiro ; Takahashi, Yasushi ; Nunoue, Tomokazu ; Wada, Takashi ; Hida, Kazuyuki ; Akai, Hiroaki ; Kamei, Shinji ; Nakamura, Tohru ; Ando, Shinichiro ; Murao, Satoshi ; Sugano, Hisashi ; Kuramoto, Hiromi ; Yoshida, Michihiro ; Sakamoto, Kota ; Kawanami, Daiji ; Nakamura, Akihiko ; de Zeeuw, Dick ; Suzuki, Daisuke
Introduction:
In the canagliflozin in type 2 diabetic patients with microalbuminuria in Japanese population (CANPIONE) study with a novel preintervention slope design, canagliflozin attenuated the decline in creatinine-based estimated glomerular filtration rate (eGFR-creatinine) slope in patients with type 2 diabetes mellitus and microalbuminuria. However, because serum creatinine is affected by muscle mass, the reliability of the eGFR-creatinine slope may be limited. Therefore, this prespecified exploratory analysis aimed to evaluate the effect of canagliflozin on the cystatin C-based eGFR (eGFR-cystatin C) slope, which is less affected by muscle mass, to validate the robustness of the previous findings.
Methods:
The chronic eGFR-cystatin C and eGFR-creatinine slopes were assessed using a 2-slope linear spline mixed-effects model. Pearson correlation coefficients were used to evaluate associations between changes in eGFR and body composition-related parameters.
Results:
eGFR trajectories were directionally consistent across both filtration markers. The chronic eGFR-cystatin C slopes in the canagliflozin and control groups were -0.4 (95% confidence interval [CI], -2.6 to 1.8) and -4.9 (-7.1 to -2.6) ml/min per 1.73 m2/year, respectively, corresponding to a between-group difference of 4.4 (1.3-7.6) ml/min per 1.73 m2/year. Similar trends were observed in the eGFR-creatinine slopes derived from the same time points, yielding a comparable treatment effect on the chronic slope (between-group difference: 3.5 [0.2-6.8] ml/min per 1.73 m2/year). Canagliflozin reduced body weight, body mass index (BMI), and waist circumference, whereas little correlation was observed between these changes and changes in eGFR-cystatin C.
Conclusion:
Incorporating the eGFR-cystatin C slope analysis supports the robustness of the previous creatinine-based slope findings, suggesting that the eGFR-creatinine slope analysis retains reasonable clinical reliability in patients treated with sodium-glucose cotransporter 2 inhibitors (SGLT2is).
321
项与 卡格列净 相关的新闻（医药）2026-05-05
·短话说肾
肾病线上咨询请点这里
2025+KDIGO+IgA肾病和IgA血管炎临床实践管理指南.pdf
2025-KDIGO-IgA肾病和IgA血管炎临床实践管理指南(中文翻译版).pdf
中国成人IgA肾病及IgA血管炎肾炎临床实践指南（2025）.pdf
导读
长期以来，慢性肾脏病被视为不可逆转的进展性疾病，治疗目标仅限于延缓肾功能恶化。
然而，随着SGLT2抑制剂、非甾体类盐皮质激素受体拮抗剂、GLP-1受体激动剂等创新疗法的出现，这一传统认知正被彻底颠覆。
近期《国际肾脏》杂志在线发表了由Navdeep Tangri教授领衔的国际权威专家团队撰写的特约社论，首次系统提出将“慢性肾脏病缓解”作为新的治疗目标，标志着肾病治疗理念的根本性转变。
01
重新定义治疗目标
从延缓进展到实现缓解
慢性肾脏病的治疗范式正在经历革命性转变。
过去三十年，见证了从单纯延缓疾病进展到真正实现病情缓解的重大突破。
这一转变的核心在于对“缓解”概念的重新界定—对于中重度慢性肾脏病患者，缓解意味着肾功能年下降速度小于1毫升/分钟/1.73平方米（与健康老龄化相当）；
对于早期患者，则要求肾功能恢复正常且无蛋白尿。
这个全新的定义将治疗目标从“推迟透析”提升到了“维持肾脏健康”的高度。
02
糖尿病肾病
缓解已成现实目标
在糖尿病肾病领域，治疗效果取得了显著进步。
早期研究中，安慰剂组的肾功能年下降速度高达10~15毫升/分钟/1.73平方米，即使使用血管紧张素转换酶抑制剂也只能modestly减缓至8~10毫升/分钟/1.73平方米。
随着SGLT2抑制剂的问世，CREDENCE研究显示卡格列净能将肾功能下降速度从每年4.52毫升/分钟改善至1.85毫升/分钟。
更令人振奋的是，联合治疗带来了更大获益：SGLT2抑制剂与GLP-1受体激动剂联用可使肾功能下降速度进一步减缓至每年1.3~1.5毫升/分钟。
最近的CONFIDENCE试验证实，大多数患者在接受SGLT2抑制剂与非甾体类盐皮质激素受体拮抗剂联合治疗后，蛋白尿水平下降超过50%。
这些突破性进展表明，实现糖尿病肾病缓解已成为可行的临床目标。
03
肾小球疾病
迈向缓解新时代
在肾小球疾病领域，治疗理念同样需要更新。
以IgA肾病为例，传统治疗下患者肾功能年下降速度约为2~3毫升/分钟/1.73平方米。
而新型靶向B细胞疗法能够将这一数字降至约1毫升/分钟/1.73平方米。
这意味着，针对疾病根本免疫机制的治疗，结合传统支持疗法，能够显著提高缓解可能性。
这种治疗策略的转变，为肾小球疾病患者带来了前所未有的希望。
04
实现缓解的关键路径
实现慢性肾脏病缓解需要多管齐下。
首先，早期发现至关重要—通过系统性的肾功能和蛋白尿筛查，在疾病早期阶段及时干预。
其次，必须克服临床惰性，积极采用联合治疗方案。
现有证据表明，联合使用RAS抑制剂、SGLT2抑制剂、非甾体类盐皮质激素受体拮抗剂和GLP-1受体激动剂等药物，能够最大程度地实现蛋白尿正常化和肾功能稳定。
最后，需要建立以初级医疗为主导、专科医生提供支持的分级诊疗体系，确保患者能够及时获得最佳治疗。
05
展望未来
慢性肾脏病治疗的转折点:缓解不再是一个遥远的概念，而是可以通过现有疗法实现的具体目标。
这一转变要求整个肾病学界更新治疗理念，从医疗政策制定到临床实践，都需要围绕“实现缓解”这一目标进行重构。
随着更多创新疗法的出现和治疗策略的优化，慢性肾脏病的治疗前景从未如此光明。
现在是时候将治疗重点从“延缓疾病进展”彻底转向“维持肾脏健康”，为全球数百万慢性肾脏病患者带来新的希望。
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肾病综合征的“三高一低”
IgA肾病免疫治疗药物归类梳理
慢性肾炎也有“中国地域特色”
如何综合判断肾脏健康状况
Telitacicept控IgAN蛋白尿
平衡RAASi应用与高钾血症风险
WHO首个关于肾脏健康决议
非奈利酮治IgA肾病循证升级
AI预测急性肾损伤能提前两天
早期蛋白尿缓解与IgAN患者长期预后
为何服用SGLT2i需多喝水
重磅:2025中国IgA肾病指南发布
CKD患者从UACR>10mg/g起风险高
耐赋康®被纳入《中国IgAN指南(预审版)》
eGFR差异越大死亡风险越低
守护肾脏健康背诵ABCDE
SGLT2i在CKD患者中应用要点
何时选基于"胱抑素C″的eGFR
GFR三年总斜率是CKD关键终点
IgA肾病预后评估需看GS比例
KDIGO IgA肾病指南(草案)解读
用RAASi后血钾升高怎么解
IgAN多机制联合治疗临床价值
近九成人不知自己患肾脏病
中国东南部肾病谱数据发布
《2025中国狼疮肾炎指南》发布
蛋白尿>0.5g/g时IgAN风险增
尿路感染是SGLT2i的“甜蜜负担”
激素用于不同蛋白尿IgAN患者疗效
KDIGO首部儿童肾病综合征指南发布
最新中国DKD流行病学调查结果
睡得过長增肾小管损伤风险
血压忽高忽低比高血压更危险
SGLT2i和RAASi联用降血钾
雷夫利珠单抗降IgAN蛋白尿
IgAN患者尿蛋白控制目标差异
IgA肾病治疗呼吁新的范式
不同人群GFR升高的不同评估
如何解读IgA肾病病理报告
黄瓜是肾病患者的"天然良药″
耐赋康®获国家药监局完全批准
CKD患者体力活动和锻炼共识
蛋白尿.高血压.肾功能三者关系
重视肾损伤分子-1的检测
IgA肾病当前治疗方案最新进展
肾穿前后注意事项与并发症处理
13项尿液检查指标意义解析
很伤肾的六种喝水方式
IgA肾病尿毒症风险到底是多少
三类少尿临床特点和诊断依据
RASi早期联合SGLT2i心肾双护
肾动脉狭窄何时需要警惕
耐赋康®的临床适用相关问题
血肌酐升高为何要用碳酸氢钠
APRIL如何改写IgA肾病"命运"
肾脏体积增大或缩小常见病变
短话说肾文辑25年04月
共探IgA肾病诊疗新未来
CKD患者怎样补充维生素
肾功能与健康预期寿命的关系
CKD管理需关注甲状腺功能
肾病常用六类评分工具解读
SGLT-2ⅰ保护晚期CKD患者心肾
二年蛋白尿轨迹预测IgAN进展
慢性肾脏病患者可以喝咖啡吗
盘点延缓CKD进展新靶点药物
短期GFR斜率预测CKD终点
从中国数据看IgA肾病治疗变革
各类肾病的长期生存情况调查
凤毛麟角的二种“降尿素氮”药物
到了尿毒症期是早透还是晚透
中国IgA肾病流行病学全景图
激素的种类与应用及注意事项
CKD蛋白尿管理用好四类药
中西医结合治疗IgAN临床实践
CKD治疗进入SGLT2i新时代
肾内科AER与ACR指标区别解析
非奈利酮降低UACR达48%
用SGLT2i的尿路感染风险如何
《短话说肾》封面图片解析
《短话说肾》封面图集
KDIGO 2024 IgAN指南更新解读
非奈利酮联合与单药治疗比较
全球CKD指南"圣经级"更新的价值
蛋白尿轨迹是IgAN进展预测因素
肾小球滤过功能的评估方法
肾彩超检查的四类指标解读
切除阑尾治疗IgA肾病有效吗
解密牙周炎与CKD之间的联系
CKD患者eGFR与卒中风险相关
憋尿的危害竟然如此之大
深海鱼油治疗IgA肾病存争议
CKD患者发生低血压怎么办
肾小球疾病与长期不良健康结局
慢性肾脏病的二项治疗目标
达格列净延缓eGFR下降速率
血常规指标肾友全解读
为什么肥胖会伤肾
CKD是心衰患者的沉默杀手
血尿的八个常见错误观点
女人和男人谁的肾更脆弱
疗效数据看SGLT2i心肾双护
亚洲首例异种肾移植患者术后超30天
独居悄悄加速肾衰竭风险
eGFR才是肾功能的“生命线”
肾脏“求救信号”→尿液"管型"
尿常规肾功能检查趣图
我国IgA肾病的地理版图
CKD的5类常用治疗用药
浅谈肾损早期标志物尿NAG
肾功能指标与死亡率随机研究
泽戈奇拜单抗治IgAN1/2期试验
低eGFR的流行病学患病率
NS-IgAN临床病理特征及预后
腰围越大CKD风险越高
肌酐可量化老年人肌肉量
IgAN创新药西贝瑞单抗申报上市
无论CKD早晚期SGLT2i都可降死亡率
达格列净降蛋白尿效果因人而异
重磅:阿曲生坦获FDA加速批准
CKD"微炎症"的七类治疗药物
SGLT-2i治疗晚期肾病也有效
谁来预测IgAN長期进展风险
早期发现CKD的五个关键步骤
肾脏移植四问四答
肾脏国际杂志|您的肾脏还好吗
真实世界中泰它西普治IgAN有效
《睡眠健康核心信息及释义》
IgAN狡诈和凶残程度远超想象
专家揭秘SGLT2i的"隐藏技能"
短话说肾文辑25年03月
耐赋康®去年7个月卖了3.5亿
突破传统的CKD新型生物标志物
达格列净适合我用吗？
耐赋康®的现实与预期里程碑
CKD治疗进入综合保护新纪元
肾移植有望不受限血型匹配
IgAN性别差异背后的医学密码
GLP-1RAs护CKD患者心肾获益
肾源稀缺"边缘供肾″势在必行
IgA肾病诊断困境及生物标志物
系统梳理CKD的防治策略
不同年龄eGFR正常参考范围
SGLT2i治疗后eGFR下降怎么解
有蛋白尿患者心脏骤停风险升71%
阿塞西普治疗IgAN疗效分析
破解老年CKD与衰弱恶性循环
警惕"肠病″伤肾的无声警报
中国CKD流行病学和疾病负担
狼疮肾炎诊疗的十个关键
肾病瞄准肥胖患者的九个问题
非奈利酮重塑CKD治疗格局
SGLT2i竟是从苹果树意外而来
蛋白尿管理的5大误区
阿塞西普治IgAN長期有效安全
SGLT2i开启CKD综合治疗新范式
睡眠时间过長增肾损害风险
国际IgA肾病联盟主席最新综述
读懂"肾三联″3大类治疗药物选用
心肾“共管”抓2指标降风险
APRIL在IgAN治疗中的潜力
细数SGLT2i跨越百年成長史
列净类药常用知识5问5答
梳理IgA肾病新药研究及治疗突破
CKD一线药物联用再获循证支持
达格列净和恩格列净的区别
泰它西普治IgAN随机II期研究
CKD一线治疗药物重塑治疗格局
SGLT2i推荐哪些CKD患者用
IgAN不建议起始免疫抑制治疗
CKD治疗一线药物又有新发现
图表告知体检做哪些肾检项目
新型药物引领下的CKD指南变迁
eGFR随时间波动与肾脏结局相关
补体抑制剂治IgAN两月给药一次
梳理CKD治疗的5大类常用药
eGFR斜率可预测老年心衰风险
可买到医保价耐赋康®的医院药店
肾小球滤过率下降意味什么
早诊早治穿透"肾"生不确定性
耐赋康®己409家执行医保价格
系膜IgM沉积对IgAN预后作用
肾脏是全身最能"忍"的器官
守护肾脏是生命延续的必答题
抓住肾病“蛛丝马迹”ABCDE法
“肾“陷迷茫之穿透人生
IgA肾病从经验用药到精准医疗
CKD患者睡眠障碍的诊治进展
谈谈肾动脉狭窄的症状与诊治
IgA肾病风险预测关键指标评估
CKD患者“症状关卡”如何度过
二表定肾功能不全者药物调整
SGLT2i连获国内外指南一线推荐
慢性扁桃体炎和IgA肾病
小小碳酸氢钠对肾脏好处多
耐赋康®报销前价每合5千值得用吗
不同肾病如何规范使用激素
肾病好不好治看看补体C3
IgAN病理报告关键指标与分级
肌酐超标一点肾脏有问题吗
CKM综合征死亡累积发病率
IgA肾病新兴疗法及获批药物
肾小球滤过率的十个问题
训练减小eGFR快速下降风险
耐赋康®的用法用量和注意事项
恩格列净给患者带来长期心肾获益
IgAN传统治疗方案的三大争议
少尿的定义原因与产生机制
IgAN血尿背后的真相与策略
CKD3期最新研究新发现
伊普可泮治IgAN Ⅲ期研究揭晓
2025新版GFR计算公式发布
鸿篇巨著:IgA肾病规范化诊疗全书
炎症评分与发生CKD的风险
关于IgAN新药"耐赋康″详细信息
肾科常用又有潜在肾毒性药物
短话说肾文辑25年02月
临床结果细胞疗法临床2期
2026-04-30
*本资料仅供医疗卫生专业人士参考，请勿向非医疗卫生专业人士发放
截至04月30日15点59分，近期共有 579 本期刊发布了 1148 篇文章，其中糖尿病相关的文章共 344 篇，覆盖 32 个领域的内容。中国专家参与发表的文章有 109 篇。今日，影响因子最高的文章刊登在 Journal of the American Medical Association (IF: 55.000) 期刊上。
今日头条
Headlines
01 Wound repair and regeneration IF: 03.400 糖尿病足溃疡住院后30天再入院：一项全国性分析
Sanaka, Krishna O, Mitra, Nandita, Margolis, David J, etc.
糖尿病足溃疡是糖尿病成人住院的常见原因，与高发病率和死亡率相关。住院后再入院仍然常见，但描述再入院模式和驱动因素的全国代表性证据有限。
这项回顾性队列研究使用了2022年美国全国再入院数据库，旨在描述30天全因再入院率，识别与再入院相关的因素，并比较美国糖尿病足溃疡住院成人的指标住院和再入院情况。通过诊断代码识别诊断为糖尿病足溃疡的成人住院，并进行调查加权分析以生成全国估计。
在估计的234,797次初始住院中，13.3%的患者在30天内再入院，超过了全国住院患者平均水平8.2%。再入院患者中肾脏疾病、心血管疾病和精神健康状况的患病率更高。多变量分析显示，肾脏疾病、心血管合并症、烟草使用、药物使用障碍和双相情感障碍与再入院风险增加相关。相反，初始住院期间的感染相关诊断和手术，包括骨感染、手术清创和下肢截肢，与再入院风险降低相关。再入院住院时间更长，急性全身性疾病患病率更高。
这些发现表明，糖尿病足溃疡住院后早期再入院主要由全身性医疗不稳定驱动，而非局部感染复发，强调了多学科住院和出院后护理策略的必要性。
本文由 韩玉莲 编辑
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Wound repair and regeneration | Volume 34, Issue 3
10.1111/wrr.70165
02 Journal of diabetes IF: 03.700 糖尿病神经病变的人口统计学和临床特征：来自2012-2017年韩国国民健康保险服务的数据
Jeong, Su Jin, Kim, Sun Keun, Kim, Chong Hwa, etc.
糖尿病神经病变（DN）是2型糖尿病（T2DM）最常见的慢性并发症，既往研究报告的患病率在23%至54.5%之间。本研究利用韩国国民健康保险服务（NHIS）2012年至2017年的数据，评估了DN的患病率、临床特征及治疗情况。
研究分析了NHIS样本数据中870万按年龄、性别、资格和收入分层的人群。DN的定义采用ICD-10编码（E10.4-E14.4, G59.0, G63.2, G99.0）以及同时开具糖尿病和DN处方的标准。计算了糖尿病患者中每年的DN患病率，并比较了有和无DN患者的治疗模式及患者特征。
结果显示，DN患病率从2012年的23.4%下降至2017年的21.5%。约半数DN患者接受了药物治疗，其中单药治疗比例高达82%，二联治疗占15%，三联治疗占3%。最常处方的药物是α-硫辛酸（52.1%-55.0%），其次是抗惊厥药（30.4%-34.5%）、三环类抗抑郁药、SNRIs和γ-亚麻酸。DN患者通常年龄较大，女性居多，且合并症更多，如高血压、血脂异常、心血管疾病、糖尿病足和截肢。他们更可能使用胰岛素或多种口服降糖药。
结论指出，约四分之一的T2DM患者患有DN，其中半数接受了治疗，主要为α-硫辛酸单药治疗。DN患者往往年龄较大且合并多种疾病，导致住院率更高。
本文由 天纳乾坤 编辑
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Journal of diabetes | Volume 18, Issue 5
10.1111/1753-0407.70196
03 JAMA dermatology IF: 11.000 美国国家银屑病基金会关于GLP-1受体激动剂治疗银屑病的入门指南：综述
Samip Sheth, Joseph F. Merola, Brittany N. Weber, Ronald Prussick, Jensen Yeung, Clive Liu, etc.
美国国家银屑病基金会医学委员会近日在《JAMA dermatology》上发表了一篇综述，为皮肤科医生介绍了GLP-1受体激动剂（GLP-1 RAs）在银屑病治疗中的应用。
银屑病是一种慢性免疫介导疾病，常伴有心血管、代谢、肌肉骨骼、精神、肝脏、肾脏和肺部共病。GLP-1 RAs已获美国食品药品监督管理局批准用于2型糖尿病、肥胖、心血管风险降低、慢性肾脏病、阻塞性睡眠呼吸暂停和代谢功能障碍相关脂肪性肝炎，这些疾病在银屑病患者中常见。新出现的证据表明，GLP-1 RAs和双重葡萄糖依赖性促胰岛素多肽/GLP-1激动剂可能通过免疫调节改善银屑病皮损。如果在大规模随机临床试验中得到证实，基于GLP-1的疗法可能为同时治疗皮肤疾病和心血管代谢共病提供机会。
综述的观察部分指出，GLP-1 RAs与银屑病面积和严重程度指数（PASI）评分降低相关，尤其在肥胖或2型糖尿病患者中。研究报告PASI相对降低约40%至80%，同时生活质量改善，但大多数研究规模较小（7-48例患者）、短期（≤6个月）且缺乏对照组。司美格鲁肽和利拉鲁肽与C反应蛋白、白细胞介素-6、血脂和内脏脂肪减少相关。在小型转化队列中，PASI改善与浅表脂肪和真皮γδ T细胞密度减少相关。GLP-1 RAs可与甲氨蝶呤、环孢素和生物制剂安全联用。不良反应主要为短暂胃肠道症状，胰腺炎和胆囊事件罕见。早期数据显示代谢和免疫调节双重益处。
综述结论认为，基于GLP-1的疗法靶向银屑病中共享的代谢和炎症通路。当前证据支持在选定的代谢共病患者中考虑辅助使用，但最终结论尚需更大规模随机临床试验证实。
本文由 韩玉莲 编辑
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JAMA dermatology | Ahead of Print.
10.1001/jamadermatol.2026.0859
04 Frontiers in endocrinology IF: 04.600 糖尿病视网膜病变与焦虑和抑郁的双向关系：一项荟萃分析
Fan, Seng, Gai, Ziyue, Ma, Hui, Wen, Ziye, Ma, Chunlei, Fan, Dongying, etc.
一项发表于《Frontiers in Endocrinology》的荟萃分析系统评估了糖尿病视网膜病变（DR）与焦虑、抑郁之间的双向关系。研究共纳入34项观察性研究，涉及383,195例患者，覆盖14个国家。
结果显示，DR患者发生抑郁的风险显著高于非DR患者（OR=1.58，95%CI:1.24-2.02，P<0.001）；反之，抑郁患者发生DR的风险也显著升高（OR=2.13，95%CI:1.53-2.98，P<0.001），提示两者存在双向关系。此外，DR患者发生焦虑的风险是非DR患者的2.23倍（95%CI:1.07-4.68，P=0.033）。
亚组分析表明，研究设计、地区和混杂因素可能是异质性的来源。敏感性分析显示结果总体稳健，但存在发表偏倚。
研究建议，在DR的临床治疗中应重视患者的心理状态，实施个性化心理护理，以改善患者预后。
本文由 韩玉莲 编辑
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Frontiers in endocrinology | Volume 17, Issue
10.3389/fendo.2026.1764745
中国发表（109）
China
Scientific reports IF: 03.900Ahead of Print.No.01A case control study of subjective sleep characteristics and polycystic ovary syndrome主观睡眠特征与多囊卵巢综合征的病例对照研究DOI: 10.1038/s41598-026-50477-3
Complement Ther Clin Pract IF: 03.000Ahead of Print.No.02Effect of acupoint catgut embedding therapy on polycystic ovary syndrome: a systematic review and meta-analysis穴位埋线疗法对多囊卵巢综合征有效性的系统评价与Meta分析DOI: 10.1016/j.ctcp.2026.102056
Journal of hazardous materials IF: 11.300Ahead of Print.No.03Biomarker-anchored screening of dietary microplastics via a gut microbiota-informed machine learning model基于肠道微生物组信息的机器学习模型实现膳食微塑料的生物标志物锚定筛查DOI: 10.1016/j.jhazmat.2026.142219
Chung-Hua Wai K'o Tsa ChihAhead of Print.No.04[Define benchmarks for low-risk sleeve gastrectomy: based on the greater China metabolic and bariatric surgery database]低风险袖状胃切除术的基准定义：基于大中华区减重代谢手术数据库DOI: 10.3760/cma.j.cn112139-20251110-00525
Orthopaedic surgery IF: 02.100Ahead of Print.No.05Research Progress on Risk Factors for Acute Kidney Injury After Antibiotic-Loaded Bone Cement Spacer Treatment for Periprosthetic Joint Infection抗生素骨水泥间隔物治疗假体周围感染后急性肾损伤危险因素的研究进展DOI: 10.1111/os.70327
Mol Cell Endocrinol IF: 03.600Ahead of Print.No.06Adiponectin ameliorates chronic-intermittent-hypoxia-induced insulin resistance by modulating macrophage inflammation in visceral white adipose tissue脂联素通过调节内脏白色脂肪组织巨噬细胞炎症改善慢性间歇性缺氧诱导的胰岛素抵抗DOI: 10.1016/j.mce.2026.112809
Biomaterials advances IF: 06.000Ahead of Print.No.07A upper critical solution temperature- and synergistic antioxidant-responsive tremella polysaccharide hydrogel for enhancing diabetic wound healing一种上临界溶解温度和协同抗氧化响应的银耳多糖水凝胶促进糖尿病伤口愈合DOI: 10.1016/j.bioadv.2026.214900
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.08Association Between Maternal Diabetes and the Risk of Cancers in Mother-Offspring: A Meta-Analysis of 44.9 Million Pregnancies母亲糖尿病与母子癌症风险的关联：一项基于4490万妊娠的荟萃分析DOI: 10.1111/dom.70835
Scientific data IF: 06.900Ahead of Print.No.09Chinese Food Images for Full-cycle Nutrition Analysis Towards Diabetes Management面向糖尿病管理的全周期营养分析的中餐图像数据集DOI: 10.1038/s41597-026-07334-9
Endocrine journal IF: 02.100Ahead of Print.No.10Soluble tumor necrosis factor receptors in diabetes: risk sensing and receptor-resolved targeting糖尿病中可溶性肿瘤坏死因子受体：风险感知与受体靶向策略DOI: 10.1507/endocrj.EJ26-0050
Diabetes & metabolic syndrome IF: 03.400Ahead of Print.No.11Letter to the editor-The predictive value of estimated glucose disposal rate for all-cause and cardiovascular mortality in the US non-diabetic population aged ≥60 years: A population-based cohort study致编辑的信——估计葡萄糖利用率对美国≥60岁非糖尿病人群全因和心血管死亡率的预测价值：一项基于人群的队列研究DOI: 10.1016/j.dsx.2026.103419
Talanta IF: 06.100Ahead of Print.No.12A novel time-gated luminescent ruthenium(II) complex probe for highly sensitive detection of methylglyoxal in foods and complex biological samples一种新型时间门控发光钌(II)配合物探针用于食品和复杂生物样品中甲基乙二醛的高灵敏检测DOI: 10.1016/j.talanta.2026.129907
Environmental research IF: 07.700Ahead of Print.No.13Long-term exposure to ambient PM(2.5) constituents and risk of microvascular complications among individuals with type 2 diabetes mellitus: a nationwide cohort study in UK长期暴露于环境PM2.5组分与2型糖尿病患者微血管并发症风险：一项英国全国性队列研究DOI: 10.1016/j.envres.2026.124589
Photodiagnosis Photodyn Ther IF: 02.600Ahead of Print.No.14Correlation between fundus color and retinal microcirculation in Type 2 Diabetes Mellitus patients2型糖尿病患者眼底颜色与视网膜微循环的相关性DOI: 10.1016/j.pdpdt.2026.105493
Ophthalmology IF: 09.500Ahead of Print.No.15Decoding Gene-Lifestyle Synergy in Diabetic Retinopathy Development: A Transethnic Prospective Cohort Study解码糖尿病视网膜病变发展中的基因-生活方式协同作用：一项跨种族前瞻性队列研究DOI: 10.1016/j.ophtha.2026.04.017
Biomedizinische Technik IF: 01.800Ahead of Print.No.16RetinalFRNet: retinal vessel segmentation in OCTA images using the feature reconstruction networkRetinalFRNet：利用特征重建网络在OCTA图像中进行视网膜血管分割DOI: 10.1515/bmt-2026-0107
Bioorganic chemistry IF: 04.700Ahead of Print.No.17Puerarin alleviates type 2 diabetes by targeting AKT1 to inhibit ferroptosis: Integrating network pharmacology, proteomics and experimental validation葛根素通过靶向AKT1抑制铁死亡缓解2型糖尿病：网络药理学、蛋白质组学与实验验证的整合研究DOI: 10.1016/j.bioorg.2026.109915
Immunopharmacol Immunotoxicol IF: 03.000Ahead of Print.No.18Vildagliptin alleviates cardiomyocyte apoptosis and inflammatory responses in the treatment of non-valvular atrial fibrillation by regulating the NO/sGC/cGMP signaling pathway维格列汀通过调节NO/sGC/cGMP信号通路减轻非瓣膜性心房颤动中的心肌细胞凋亡和炎症反应DOI: 10.1080/08923973.2026.2639559
Cell reports. Methods IF: 04.500Ahead of Print.No.19Integrated multi-dimensional modeling of non-model bacteria identifies engineering targets for acarbose biosynthesis optimization非模式细菌的多维整合建模鉴定阿卡波糖生物合成优化的工程靶点DOI: 10.1016/j.crmeth.2026.101426
Journal of ethnopharmacology IF: 05.400Ahead of Print.No.20Corrigendum to "Integrative pharmacology reveals the mechanisms of Erzhi Pill, a traditional Chinese formulation, against diabetic cardiomyopathy" [J. Ethnopharmacol., 296, (2022), 115474]对《整合药理学揭示传统中药方剂二至丸抗糖尿病心肌病的作用机制》[J. Ethnopharmacol., 296, (2022), 115474]的勘误DOI: 10.1016/j.jep.2026.121734
Cardiovascular Diabetology IF: 10.600Ahead of Print.No.21Metabolomic signatures of hepatic steatosis reveal heterogeneity in cardiometabolic risk and responses to lifestyle interventions in type 2 diabetes: a post hoc analysis肝脏脂肪变性的代谢组学特征揭示2型糖尿病中心血管代谢风险及生活方式干预反应的异质性：一项事后分析DOI: 10.1186/s12933-026-03194-0
ACS nano IF: 16.000Ahead of Print.No.22Self-Cascading Copper-Based Nanoassemblies Trigger Bacterial Cuproptosis-Like Death and Promote Wound Healing for Diabetic Drug-Resistant Bacterial Infections自级联铜基纳米组装体触发细菌铜死亡样死亡并促进糖尿病耐药细菌感染的伤口愈合DOI: 10.1021/acsnano.5c21619
Journal of medicinal chemistry IF: 06.800Ahead of Print.No.23Design and Synthesis of USP1 Inhibitors: Synergistic Antitumor Activity with PARP Inhibitors in Triple-Negative Breast CancerUSP1抑制剂的设计与合成：与PARP抑制剂在三阴性乳腺癌中的协同抗肿瘤活性DOI: 10.1021/acs.jmedchem.5c03804
ACS nano IF: 16.000Ahead of Print.No.24Clinically Validated Leptin Receptor as a Target for Liposomal Delivery of Metformin in Endometriosis Therapy临床验证的瘦素受体作为脂质体递送二甲双胍治疗子宫内膜异位症的靶点DOI: 10.1021/acsnano.5c18417
Gait & posture IF: 02.400Ahead of Print.No.25Multi-modal sensor fusion in smart footwear to capture altered gait dynamics in patients with diabetic peripheral neuropathy: System validation and clinical applications智能鞋具多模态传感器融合捕捉糖尿病周围神经病变患者步态动力学改变：系统验证与临床应用DOI: 10.1016/j.gaitpost.2026.110196
PloS one IF: 02.600Volume 21, Issue 4No.26Artemether ameliorates type 1 diabetic liver injury alongside the associated defects in mitochondrial ultrastructure and central carbon metabolism蒿甲醚改善1型糖尿病肝损伤及相关的线粒体超微结构和中心碳代谢缺陷DOI: 10.1371/journal.pone.0348214
Diabetes Metab Res Rev IF: 06.000Volume 42, Issue 4No.27Metformin: Historical Origins, Mechanisms of Action, and Emerging Clinical Applications二甲双胍：历史起源、作用机制及新兴临床应用DOI: 10.1002/dmrr.70171
Science progress IF: 02.900Volume 109, Issue 2No.28Leukocyte VCS parameters as potential auxiliary markers associated with diabetes and its inflammatory complications: A retrospective cross-sectional study白细胞VCS参数作为糖尿病及其炎症并发症潜在辅助标志物的回顾性横断面研究DOI: 10.1177/00368504261445505
Am J Chin Med IF: 05.500Ahead of Print.No.29Acupuncture for Neuropathic Pain: Mechanisms, Clinical Efficacy and Future Perspectives针灸治疗神经病理性疼痛：机制、临床有效性及未来展望DOI: 10.1142/S0192415X26500254
Future science OA IF: 02.100Volume 12, Issue 1No.30Mapping ophthalmic research on glycosylation and glycation: a PRISMA-compliant bibliometric and co‑citation analysis眼科糖基化与糖化研究图谱：一项符合PRISMA规范的文献计量与共引分析DOI: 10.1080/20565623.2026.2663167
International wound journal IF: 02.500Volume 21, Issue 2No.31Analysis of pathogen distribution and associated risk factors for surgical site infections following laparoscopic urological surgeries腹腔镜泌尿外科手术后手术部位感染的病原体分布及相关危险因素分析DOI: 10.1111/iwj.14721
Annals of hematology IF: 02.400Volume 105, Issue 5No.32Low dose of sitagliptin: effectively prevent liver aGVHD and accelerate neutrophil engraftment低剂量西格列汀：有效预防肝脏急性移植物抗宿主病并加速中性粒细胞植入DOI: 10.1007/s00277-026-07036-7
Minerva anestesiologica IF: 02.800Ahead of Print.No.33Efficacy of intranasal insulin in preventing postoperative delirium and its impact on insulin resistance in elderly non-cardiac surgical patients: a systematic review and meta-analysis鼻内胰岛素预防老年非心脏手术患者术后谵妄的有效性及其对胰岛素抵抗的影响：系统评价与荟萃分析DOI: 10.23736/S0375-9393.26.19719-3
Br J Hosp Med (Lond) IF: 01.800Volume 87, Issue 4No.34Clinical Efficacy of Continuous Nursing Plus Shared Outpatient Care on Remission of Type 2 Diabetes Mellitus延续性护理联合共享门诊管理对2型糖尿病缓解的临床有效性DOI: 10.31083/BJHM49861
Clin Pharmacol Drug Dev IF: 01.800Volume 15, Issue 5No.35Comparative Pharmacokinetics and Bioequivalence Assessment of Metformin/Pioglitazone Tablet in Fasting and Fed Conditions: A Randomized Study in Healthy Chinese Subjects二甲双胍/吡格列酮片在空腹和进食条件下的比较药代动力学和生物等效性评估：一项在中国健康受试者中开展的随机研究DOI: 10.1002/cpdd.70063
Br J Hosp Med (Lond) IF: 01.800Volume 87, Issue 4No.36Clinical Value of High-Channel 12-Lead Holter in Assisting Early Identification of Arrhythmias in High-Risk Populations高通道12导联动态心电图在高危人群心律失常早期识别中的临床价值DOI: 10.31083/BJHM52968
JAHA IF: 05.300Ahead of Print.No.37Allostatic Load of Glucose Homeostasis, Epigenetic Biomarkers, and All-Cause and Cardiovascular Death: A Prospective Cohort Study葡萄糖稳态的适应性负荷、表观遗传生物标志物与全因及心血管死亡：一项前瞻性队列研究DOI: 10.1161/JAHA.125.047287
Kaohsiung J Med Sci IF: 03.100Ahead of Print.No.38ZFP36L1 Enhances Microglial Ferroptosis in Ischemic Stroke by Reducing FTO-Mediated N6-Methyladenosine Demethylation of ACSL1 mRNAZFP36L1通过减少FTO介导的ACSL1 mRNA N6-甲基腺苷去甲基化增强缺血性卒中中的小胶质细胞铁死亡DOI: 10.1002/kjm2.70212
International wound journal IF: 02.500Volume 21, Issue 2No.39RETRACTED: The effect of placing drains and no drains after caesarean section in obese patients on patients' post-operative wound complications: A meta-analysis已撤回：肥胖患者剖宫产后放置引流管与不放置引流管对术后伤口并发症影响的荟萃分析DOI: 10.1111/iwj.14576
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.40Gut microbiome dysbiosis in PCOS: from pathogenesis to microbiome-targeted therapies多囊卵巢综合征中的肠道微生物群失调：从发病机制到微生物靶向治疗DOI: 10.3389/fendo.2026.1747766
BMC public health IF: 03.600Ahead of Print.No.41Associations between multiple air pollutants and insulin resistance in Chinese adults: the moderating role of physical activity多种空气污染物与中国成年人胰岛素抵抗的关联：体力活动的调节作用DOI: 10.1186/s12889-026-27595-8
Reprod Biol Endocrinol IF: 04.700Volume 24, Issue 1No.42Editorial expression of concern: Resveratrol relieves gestational diabetes mellitus in mice through activating AMPK编辑关注声明：白藜芦醇通过激活AMPK缓解小鼠妊娠期糖尿病DOI: 10.1186/s12958-026-01560-x
Fayixue zazhiVolume 42, Issue 1No.43[Synthetic Drug： Pregabalin]合成药物：普瑞巴林DOI: 10.12116/j.issn.1004-5619.2026.360302
BMC ophthalmology IF: 01.700Volume 26, Issue 1No.44Correlation between the expression levels of miR-199a-3p and FN1 in serum and aqueous humor and the severity of type 2 diabetic retinopathy in a Chinese population中国人群中血清和房水中miR-199a-3p与FN1表达水平与2型糖尿病视网膜病变严重程度的相关性DOI: 10.1186/s12886-026-04838-1
BMC endocrine disorders IF: 03.300Ahead of Print.No.45The role of resistance training in improving beta-cell function in type 2 diabetes: a systematic review and meta-analysis抗阻训练改善2型糖尿病β细胞功能的作用：系统综述与荟萃分析DOI: 10.1186/s12902-026-02286-y
Journal of nanobiotechnology IF: 12.600Ahead of Print.No.46Extracellular vesicles inherit lactate from aggregated MSCs to alleviate type 1 diabetes mellitus via H(2)S-induced CD8(+) T cell exhaustion细胞外囊泡继承聚集间充质干细胞的乳酸通过H2S诱导CD8+ T细胞耗竭缓解1型糖尿病DOI: 10.1186/s12951-026-04466-3
Frontiers in psychiatry IF: 03.200Volume 17, Issue No.47The associations of systemic inflammation and insulin resistance-related indicators with psychopathology and BDNF in patients with chronic schizophrenia慢性精神分裂症患者全身炎症和胰岛素抵抗相关指标与精神病理学及BDNF的关联DOI: 10.3389/fpsyt.2026.1802167
Frontiers in neurology IF: 02.800Volume 17, Issue No.48Beyond BMI: independent and opposing effects of overweight and obesity and triglycerides on 90-day functional outcomes after acute ischemic stroke超越体重指数：超重与肥胖和甘油三酯对急性缺血性卒中后90天功能结局的独立且相反的影响DOI: 10.3389/fneur.2026.1782157
Frontiers in immunology IF: 05.900Volume 17, Issue No.49Targeted regulation of adipose tissue macrophages from an immunometabolic perspective: a novel therapeutic approach for obesity-related metabolic disorders从免疫代谢角度靶向调控脂肪组织巨噬细胞：肥胖相关代谢性疾病的新治疗策略DOI: 10.3389/fimmu.2026.1803488
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.50Association between stress hyperglycemic ratio and stroke in older people with metabolic syndrome: a prospective cohort study from UK Biobank应激性高血糖比率与代谢综合征老年人群卒中风险的关联：一项来自英国生物样本库的前瞻性队列研究DOI: 10.3389/fendo.2026.1758847
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.51Endocrine-informed monitoring of scoliosis in Prader-Willi syndrome: integrating neuroendocrine pathophysiology, growth hormone therapy, and pubertal transitionPrader-Willi综合征脊柱侧弯的内分泌指导监测：整合神经内分泌病理生理学、生长激素治疗与青春期过渡DOI: 10.3389/fendo.2026.1803919
FCVM IF: 02.900Volume 13, Issue No.52Efficacy and safety of levosimendan in acute heart failure patients with different body mass index: a multicenter, retrospective, observational real-world study左西孟旦在不同体重指数急性心力衰竭患者中的有效性和安全性：一项多中心、回顾性、观察性真实世界研究DOI: 10.3389/fcvm.2026.1790085
Frontiers in nutrition IF: 05.100Volume 13, Issue No.53The correlation between nutrition index scores and nutrition status of preschool children in a district of Shanghai上海市某区学龄前儿童营养指数评分与营养状况的相关性研究DOI: 10.3389/fnut.2026.1746871
Frontiers in nutrition IF: 05.100Volume 13, Issue No.54Associations of umbilical cord vitamin D levels with childhood cardiometabolic risks: a longitudinal mother-child study脐带维生素D水平与儿童期心脏代谢风险的关联：一项纵向母婴研究DOI: 10.3389/fnut.2026.1777909
Frontiers in nutrition IF: 05.100Volume 13, Issue No.55Fasting blood glucose to high-density lipoprotein cholesterol ratio and MASLD risk: non-linear association and BMI mediation in non-diabetic adults空腹血糖与高密度脂蛋白胆固醇比值与非糖尿病成人脂肪性肝病风险的非线性关联及体重指数的中介作用DOI: 10.3389/fnut.2026.1818931
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.56Predictive Value of the second-Trimester Triglyceride-Glucose Index and Its Derived Indices for Macrosomia in Gestational Diabetes Mellitus妊娠期糖尿病孕妇孕中期甘油三酯-葡萄糖指数及其衍生指数对巨大儿的预测价值DOI: 10.2147/DMSO.S577687
J Int Med Res IF: 01.500Volume 54, Issue 4No.57A metabolic-inflammatory phenotype of pelvic floor dysfunction: A machine learning-based cross-sectional study in a nationally representative US population盆底功能障碍的代谢炎症表型：一项基于机器学习、具有全国代表性的美国人群横断面研究DOI: 10.1177/03000605261438949
J Int Med Res IF: 01.500Volume 54, Issue 4No.58Association between anthropometric indices and mortality risk among individuals with depression: A population-based cohort study抑郁患者人体测量指标与死亡风险的关联：一项基于人群的队列研究DOI: 10.1177/03000605261442794
Am J Respir Cell Mol Biol IF: 05.300Ahead of Print.No.59FTO Alleviates COPD Pathogenesis by Demethylating S100A9 to Suppress ERK1/2-Drp1-Driven MitophagyFTO通过去甲基化S100A9抑制ERK1/2-Drp1驱动的线粒体自噬减轻COPD发病机制DOI: 10.1093/ajrcmb/aanag094
Diabetology & metabolic syndrome IF: 03.900Volume 18, Issue 1No.60Beyond the known: prospective research directions for the gut-brain axis in obesity and type 1 diabetes mellitus超越已知：肥胖与1型糖尿病中肠脑轴的未来研究方向DOI: 10.1186/s13098-025-02038-3
BMC women's health IF: 02.700Ahead of Print.No.61PCOS combined with obesity aggravates the metabolic and immune abnormality in females多囊卵巢综合征合并肥胖加重女性代谢与免疫异常DOI: 10.1186/s12905-026-04492-1
International wound journal IF: 02.500Volume 21, Issue 2No.62Evaluation of diabetic foot care knowledge, determinants of self-care practices and the efficacy of health education糖尿病足护理知识、自我护理实践的决定因素及健康教育的有效性评估DOI: 10.1111/iwj.14704
International wound journal IF: 02.500Volume 21, Issue 2No.63RETRACTED: Efficacy of autologous platelet-rich plasma combined with negative pressure sealing drainage in the treatment of patients with diabetic foot ulcer自体富血小板血浆联合负压封闭引流治疗糖尿病足溃疡患者的有效性：一项系统评价与荟萃分析DOI: 10.1111/iwj.14700
International wound journal IF: 02.500Volume 21, Issue 2No.64RETRACTED: Effects of continuing nursing intervention on high-risk patients with diabetic foot ulcers: A meta-analysis持续护理干预对高危糖尿病足溃疡患者有效性的荟萃分析DOI: 10.1111/iwj.14683
Frontiers in bioscience IF: 03.100Volume 31, Issue 4No.65Emodin Alleviates Lipid Accumulation and Renal Tubular Injury in Rats With DN via Inhibiting HIF-1α Expression大黄素通过抑制HIF-1α表达减轻糖尿病肾病大鼠脂质蓄积和肾小管损伤DOI: 10.31083/FBL49862
Frontiers in bioscience IF: 03.100Volume 31, Issue 4No.66Effect of Endogenous FGF21 Deficiency on the Inflammatory Microenvironment of the Retina内源性FGF21缺乏对视网膜炎症微环境的影响DOI: 10.31083/FBL47702
J Integr Neurosci IF: 02.700Volume 25, Issue 4No.67Regional Associations Between Ocular Vascular Parameters and Enlarged Perivascular Spaces in the Basal Ganglia and Centrum Semiovale眼部血管参数与基底节和半卵圆中心血管周围间隙扩大的区域关联DOI: 10.31083/JIN49070
J Diabetes Investig IF: 03.000Ahead of Print.No.68Comment on 'Glycemic control and renal function decline in patients with chronic coronary syndrome: A multicenter cohort study'对《慢性冠状动脉综合征患者的血糖控制与肾功能下降：一项多中心队列研究》的评论DOI: 10.1111/jdi.70325
Materials horizons IF: 10.700Ahead of Print.No.69Multi-kingdom biofilms breached: microneedle delivery of metabolically targeted organic silver-photosensitizers for polymicrobial infections in diabetic foot ulcers多界生物膜突破：微针递送代谢靶向有机银光敏剂治疗糖尿病足溃疡中的多种微生物感染DOI: 10.1039/d6mh00459h
J Diabetes Investig IF: 03.000Ahead of Print.No.70Letter to the Editor in response to the article 'Prevalence and risk factors of sarcopenia in Asian adults with type 2 diabetes: A systematic review and meta-analysis'对《亚洲2型糖尿病成人肌少症的患病率与危险因素：系统综述与荟萃分析》一文的致编辑信DOI: 10.1111/jdi.70323
Frontiers in surgery IF: 01.800Volume 13, Issue No.71Risk factors associated with postoperative necrosis after digital replantation: a systematic review and meta-analysis断指再植术后坏死相关危险因素的系统评价与Meta分析DOI: 10.3389/fsurg.2026.1795247
Frontiers in neurology IF: 02.800Volume 17, Issue No.72Incidence of cognitive impairment post first stroke: a systematic review and meta-analysis首次卒中后认知障碍发生率的系统评价与荟萃分析DOI: 10.3389/fneur.2026.1782749
Frontiers in physiology IF: 03.400Volume 17, Issue No.73Efficacy and safety of gabapentinoid combination therapy versus monotherapy for the treatment of neuropathic pain加巴喷丁类药物联合治疗与单药治疗神经病理性疼痛的有效性和安全性比较DOI: 10.3389/fphys.2026.1802999
Frontiers in medicine IF: 03.000Volume 13, Issue No.74Incidence and risk factors of oral mucosal pressure injury in patients with oral tracheal intubation: systematic review and meta-analysis经口气管插管患者口腔黏膜压力性损伤发生率及危险因素的系统评价与Meta分析DOI: 10.3389/fmed.2026.1783726
Frontiers in medicine IF: 03.000Volume 13, Issue No.75Association between serum 25-hydroxyvitamin D, nutritional status, and inflammatory markers in sepsis patients with and without sarcopenia脓毒症合并与不合并肌少症患者血清25-羟基维生素D、营养状态和炎症标志物的关联研究DOI: 10.3389/fmed.2026.1816016
Frontiers in medicine IF: 03.000Volume 13, Issue No.76Construction and validation of a machine learning-based prediction model for postoperative complications in patients with chronic otitis media基于机器学习的慢性中耳炎术后并发症预测模型的构建与验证DOI: 10.3389/fmed.2026.1805224
Frontiers in medicine IF: 03.000Volume 13, Issue No.77Impact of liuwei dihuang pills (decoction) on early diabetic nephropathy: a systematic review and meta-analysis六味地黄丸（汤）对早期糖尿病肾病影响的系统评价与Meta分析DOI: 10.3389/fmed.2026.1802975
Maternal-fetal medicine IF: 01.700Volume 8, Issue 2No.78Global Guidelines on Placenta Accreta Spectrum Disorders: A Commentary From the Chinese Perspective全球胎盘植入性疾病指南：来自中国视角的评论DOI: 10.1097/FM9.0000000000000320
Frontiers in immunology IF: 05.900Volume 17, Issue No.79Influences of dietary intake on Chinese women with gestational diabetes mellitus by inhibiting gut microbiome on plasma metabolome膳食摄入通过抑制肠道微生物组对血浆代谢组的影响在中国妊娠期糖尿病女性中的作用DOI: 10.3389/fimmu.2026.1745459
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.80Association of the glucose metabolism continuum (fasting plasma glucose/HbA1c) with tear-film stability and secretion: ocular surface evidence across non-diabetes, prediabetes, and diabetes血糖代谢连续谱（空腹血糖/糖化血红蛋白）与泪膜稳定性和分泌的关联：跨越非糖尿病、糖尿病前期和糖尿病的眼表证据DOI: 10.3389/fendo.2026.1788051
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.81Machine learning-based prediction of NAFLD in patients with type 2 diabetes using routine clinical and biochemical indicators基于常规临床和生化指标的机器学习预测2型糖尿病患者非酒精性脂肪性肝病DOI: 10.3389/fendo.2026.1761846
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.82New findings in diabetic kidney disease: correlation and enhanced combined diagnostic value of sclerostin and 25(OH)VD糖尿病肾脏病新发现：硬骨素与25(OH)VD的相关性及联合诊断价值提升DOI: 10.3389/fendo.2026.1817017
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.83The association of serum uric acid with severity and prognosis of patients with diabetic foot ulcers血清尿酸与糖尿病足溃疡患者严重程度及预后的关联DOI: 10.3389/fendo.2026.1732361
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.84Low early-pregnancy serum lipoprotein(a) as an independent associated factor for gestational diabetes mellitus: a retrospective cohort study孕早期血清脂蛋白(a)低水平是妊娠期糖尿病的独立相关因素：一项回顾性队列研究DOI: 10.3389/fendo.2026.1780579
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.85Correction: Multi-feature integrated machine learning prediction model for early nephropathy in elderly living with type 2 diabetes mellitus更正：多特征集成机器学习预测模型用于老年2型糖尿病患者早期肾病DOI: 10.3389/fendo.2026.1807912
Int Med Case Rep J IF: 00.600Volume 19, Issue No.86Ultrasound-Guided Superior Laryngeal Nerve Block Combined with Cricothyroid Membrane Puncture for Awake Tracheal Intubation in a Patient with a Laryngeal Tumor: A Case Report and Literature Review超声引导喉上神经阻滞联合环甲膜穿刺用于喉肿瘤患者清醒气管插管：病例报告与文献综述DOI: 10.2147/IMCRJ.S589800
Frontiers in nutrition IF: 05.100Volume 13, Issue No.87Association between cumulative changes of the C-reactive protein-triglyceride glucose index and the incidence of rapid kidney function decline: a nationwide prospective cohort studyC反应蛋白-甘油三酯葡萄糖指数累积变化与肾功能快速下降发生率的关联：一项全国性前瞻性队列研究DOI: 10.3389/fnut.2026.1795444
Frontiers in nutrition IF: 05.100Volume 13, Issue No.88Structural elucidation and antidiabetic activity of polysaccharides from the parasitic plant Orobanche cumana寄生植物向日葵列当多糖的结构解析与抗糖尿病活性研究DOI: 10.3389/fnut.2026.1785297
Frontiers in nutrition IF: 05.100Volume 13, Issue No.89Microbiota-metabolites interaction associated with glycemic improvement following a dietary herbal intervention in type 2 diabetes2型糖尿病膳食草药干预后与血糖改善相关的微生物群-代谢物相互作用DOI: 10.3389/fnut.2026.1793130
Frontiers in nutrition IF: 05.100Volume 13, Issue No.90New directions in mulberry leaf research for diabetes: a translational approach based on multi-component synergy桑叶糖尿病研究新方向：基于多组分协同的转化策略DOI: 10.3389/fnut.2026.1792767
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.91FGFR1/YAP1 signaling in endothelial cells drives renal fibrosis and offers a therapeutic target内皮细胞中FGFR1/YAP1信号驱动肾脏纤维化并提供治疗靶点DOI: 10.3389/fphar.2026.1766265
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.92Paeoniflorin as a candidate disease-modifying therapy for diabetic peripheral neuropathy: mechanisms, exposure challenges, and translational priorities芍药苷作为糖尿病周围神经病变候选疾病修饰疗法：机制、暴露挑战与转化优先事项DOI: 10.3389/fphar.2026.1751578
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.93Development and Validation of a Nursing-Integrated Nomogram to Predict 1-Year Ulcer Recurrence in Patients with Diabetic Foot Ulcers After Endovascular Therapy整合护理评估的列线图预测糖尿病足溃疡患者血管内治疗后1年溃疡复发的开发与验证DOI: 10.2147/DMSO.S591186
The FASEB journal : IF: 04.200Volume 40, Issue 9No.94The E3 Ligase RNF8 Promotes Ubiquitination and Degradation of ChREBPα During Liver Stress ResponseE3连接酶RNF8在肝脏应激反应中促进ChREBPα的泛素化和降解DOI: 10.1096/fj.202600106R
Endocrinol Diabetes Metab IF: 02.600Volume 9, Issue 3No.95Hypoglycaemia Risk Prediction Models for Type 2 Diabetes: A Systematic Review and Meta-Analysis2型糖尿病低血糖风险预测模型的系统评价与荟萃分析DOI: 10.1002/edm2.70227
Journal of diabetes IF: 03.700Volume 18, Issue 5No.96Mitochondrial Homeostasis in Pancreatic β Cell Function: Mechanisms and Therapeutic Targets for Diabetes胰腺β细胞功能中的线粒体稳态：糖尿病的机制与治疗靶点DOI: 10.1111/1753-0407.70228
Chinese Medical Journal IF: 07.300Ahead of Print.No.97Molecular mechanisms and novel therapeutic targets of diabetic kidney disease糖尿病肾病的分子机制与新型治疗靶点DOI: 10.1097/CM9.0000000000004025
J Int Med Res IF: 01.500Volume 54, Issue 4No.98Emerging therapies for type 1 diabetes: Immunotherapy and gene editing advances1型糖尿病新兴疗法：免疫治疗与基因编辑进展DOI: 10.1177/03000605261440833
J Int Med Res IF: 01.500Volume 54, Issue 4No.99Endothelial activation and stress index links to cardiovascular disease in postmenopausal women mediated by arterial stiffness: A cross-sectional study of National Health and Nutrition Examination Survey 1999-2018内皮激活与应激指数与绝经后女性心血管疾病相关：动脉僵硬度的中介作用——基于1999-2018年美国国家健康与营养调查的横断面研究DOI: 10.1177/03000605261434398
J Int Med Res IF: 01.500Volume 54, Issue 4No.100Effects of probiotic supplementation on glycemic control in children with type 1 diabetes: A systematic review and meta-analysis益生菌补充对1型糖尿病儿童血糖控制的影响：系统评价与荟萃分析DOI: 10.1177/03000605261443077
Frontiers in nutrition IF: 05.100Volume 13, Issue No.101Plant-based caloric restriction diets versus conventional calorie-restricted diets for weight loss and metabolic health in obese adults: a 12-week randomized, open-label, non-inferiority trial植物性热量限制饮食与传统热量限制饮食对肥胖成人减重和代谢健康的影响：一项12周随机、开放标签、非劣效性试验DOI: 10.3389/fnut.2026.1805225
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.102Bidirectional relationship of diabetic retinopathy with anxiety and depression: a meta-analysis糖尿病视网膜病变与焦虑和抑郁的双向关系：一项荟萃分析DOI: 10.3389/fendo.2026.1764745
J Integr Neurosci IF: 02.700Volume 25, Issue 4No.103Roles of Metformin and Pioglitazone in Regulating A1-like Astrocyte Activation in EAE Mice二甲双胍和吡格列酮在调节EAE小鼠A1样星形胶质细胞激活中的作用DOI: 10.31083/JIN47364
Frontiers in microbiology IF: 04.500Volume 17, Issue No.104Metformin exacerbates diabetic amyotrophy via oxidative stress and gut microbiota alterations达格列净通过氧化应激和肠道菌群改变加重糖尿病性肌萎缩DOI: 10.3389/fmicb.2026.1778515
Frontiers in immunology IF: 05.900Volume 17, Issue No.105Sheep placental extract ameliorates polycystic ovary syndrome in rats by regulating ERβ-mediated Treg cells via the TGF-β1/Smad3 signaling pathway羊胎盘提取物通过TGF-β1/Smad3信号通路调节ERβ介导的Treg细胞改善大鼠多囊卵巢综合征DOI: 10.3389/fimmu.2026.1777841
Journal of nanobiotechnology IF: 12.600Ahead of Print.No.106Bio-inspired suction cup microneedle loaded fusion membrane targeting nano-drug delivery system treat androgenetic alopecia仿生吸盘微针负载融合膜靶向纳米递药系统治疗雄激素性脱发DOI: 10.1186/s12951-026-04391-5
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.107Quercetin in metabolic diseases: mechanisms, therapeutics, and multidimensional frontiers槲皮素在代谢性疾病中的作用：机制、治疗和多维前沿DOI: 10.3389/fendo.2026.1800322
Frontiers in public health IF: 03.400Volume 14, Issue No.108Dissociation between subjective sleep quality and lipid dysregulation in underground miners: night shift work as an independent risk factor for hypercholesterolemia井下矿工主观睡眠质量与血脂异常的解离：夜班工作是高胆固醇血症的独立危险因素DOI: 10.3389/fpubh.2026.1759787
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.109The DBC1-HIF-1α-PPAR-γ axis regulates Treg cell differentiation to promote myocardial fibrosis in experimental diabetic cardiomyopathy through the paracrine secretion of AregDBC1-HIF-1α-PPAR-γ轴通过旁分泌Areg调节Treg细胞分化促进实验性糖尿病心肌病心肌纤维化DOI: 10.3389/fendo.2026.1780666
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J Biol Chem IF: 03.900Ahead of Print.No.03The tumor suppressor NDRG2 recruits protein phosphatase 2A to suppress STAT5 phosphorylation in adult T-cell leukemia/lymphoma肿瘤抑制因子NDRG2招募蛋白磷酸酶2A抑制成人T细胞白血病/淋巴瘤中STAT5的磷酸化DOI: 10.1016/j.jbc.2026.113080
Arch Gynecol Obstet IF: 02.500Volume 313, Issue 1No.04Advanced fetal cardiac monitoring in gestational diabetes mellitus: HbA1c remains the relevant predictor of perinatal outcome under optimal metabolic control妊娠期糖尿病中的高级胎儿心脏监测：在最佳代谢控制下，HbA1c仍是围产结局的相关预测因子DOI: 10.1007/s00404-026-08427-x
Int J Behav Med IF: 01.700Ahead of Print.No.05Motivating Women with Gestational Diabetes: Are Healthcare Professionals Saying the Right Words?激励妊娠期糖尿病女性：医疗专业人员是否使用了恰当的语言？DOI: 10.1007/s12529-026-10460-8
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Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.07High Prevalence of Metabolic Dysfunction-Associated Steatohepatitis With Significant Fibrosis in Primary Care and Endocrinology Clinics初级保健和内分泌门诊中代谢功能障碍相关脂肪性肝炎伴显著纤维化的高患病率DOI: 10.1111/dom.70799
Food science of animal resources IF: 03.700Volume 44, Issue 5No.08ω-6 and ω-3 Polyunsaturated Fatty Acids: Inflammation, Obesity and Foods of Animal Resourcesω-6和ω-3多不饱和脂肪酸：炎症、肥胖与动物源食品DOI: 10.5851/kosfa.2024.e65
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European radiology IF: 04.700Ahead of Print.No.35Pacinian corpuscle loss on routine forefoot MRI as an imaging biomarker for large-fiber sensory dysfunction in type 2 diabetic polyneuropathy常规前足MRI上帕西尼小体丢失作为2型糖尿病多发性神经病中大纤维感觉功能障碍的影像生物标志物DOI: 10.1007/s00330-026-12576-7
MMW - Fortschritte der MedizinVolume 168, Issue 8No.36[Not Available][不可用]DOI: 10.1007/s15006-026-5925-8
J Gen Intern Med IF: 04.200Ahead of Print.No.37Bridging the Gap: Portal Messages as a Tool to Improve Breast Cancer and Diabetes Screening Rates弥合差距：门户消息作为提高乳腺癌和糖尿病筛查率的工具DOI: 10.1007/s11606-026-10452-0
Int Urol Nephrol IF: 01.900Ahead of Print.No.38Blood pressure effects of SGLT2 inhibitors in kidney transplant recipients: a systematic review and meta-analysisSGLT2抑制剂对肾移植受者血压影响的系统评价与荟萃分析DOI: 10.1007/s11255-026-05162-9
Scientific reports IF: 03.900Ahead of Print.No.39Effect of statins and ACE inhibitors on the metabolome in the Adolescent Type 1 Diabetes cardio-renal Intervention Trial (AdDIT) cohort他汀类药物和ACE抑制剂对青少年1型糖尿病心脏-肾脏干预试验（AdDIT）队列代谢组的影响DOI: 10.1038/s41598-026-50044-w
Nutrition & diabetes IF: 05.200Ahead of Print.No.40Distinct meal timing and frequency patterns contribute to daily glycemic variability不同的进餐时间和频率模式对每日血糖变异性的影响DOI: 10.1038/s41387-026-00424-y
West J Nurs Res IF: 01.700Ahead of Print.No.41Psychometric Properties of the Indonesian Version of the Motivation and Attitudes Toward Health Change Scale and Its Role in Glycemic Outcomes in Type 2 Diabetes印尼版健康改变动机与态度量表的心理测量学特性及其在2型糖尿病血糖结局中的作用DOI: 10.1177/01939459261437835
Ultrasound in medicine & biology IF: 02.600Ahead of Print.No.42The feasibility of combining focused ultrasound and copper-cystine biohybrid for diabetic wound healing聚焦超声与铜-胱氨酸生物杂合体联合用于糖尿病伤口愈合的可行性研究DOI: 10.1016/j.ultrasmedbio.2026.03.018
J Int Med Res IF: 01.500Volume 54, Issue 4No.43Association between appendicular lean mass-to-body weight ratio and metabolic syndrome in community-dwelling older adults in Taiwan: A cross-sectional study台湾社区老年人四肢瘦体重与体重比值与代谢综合征的关联：一项横断面研究DOI: 10.1177/03000605261443913
Tohoku J Exp Med IF: 01.600Ahead of Print.No.44Subacute-Onset Hypothyroidism in an Elderly Patient with Polymyalgia Rheumatica: A Case Report老年风湿性多肌痛患者亚急性起病甲状腺功能减退症一例DOI: 10.1620/tjem.2026.J042
J Atheroscler Thromb IF: 02.800Ahead of Print.No.45Association between cardiovascular disease risk factors and white matter lesions: The Tohoku Medical Megabank Cohort Study心血管疾病危险因素与白质病变的关联：东北医疗大型队列研究DOI: 10.5551/jat.65993
Internal medicine IF: 01.100Ahead of Print.No.46A Rare Case of Adult-Onset Human Parechovirus Type A3 Encephalitis成人发病的人副肠孤病毒A3型脑炎罕见病例DOI: 10.2169/internalmedicine.6738-25
Methods in enzymologyVolume 729, Issue No.47Single-molecule fluorescence spectroscopy and imaging of heterogeneous amyloid β aggregation异质性淀粉样β聚集的单分子荧光光谱与成像DOI: 10.1016/bs.mie.2026.01.033
Methods in enzymologyVolume 729, Issue No.48Time-resolved solid-state nuclear magnetic resonance studies of amyloid-β oligomer formation时间分辨固态核磁共振研究淀粉样蛋白-β寡聚体形成DOI: 10.1016/bs.mie.2026.01.035
Methods in enzymologyVolume 729, Issue No.49Opportunities and challenges in the use of pressure-jump NMR to study Aβ and protein oligomerization利用压力跳跃核磁共振研究Aβ和蛋白质寡聚化的机遇与挑战DOI: 10.1016/bs.mie.2026.01.036
BMJ open IF: 02.300Volume 16, Issue 4No.50Understanding the impact, reach and implementation of a health systems intervention to improve diabetes and hypertension care in pluralistic urban public primary care in Bangladesh: a study protocol理解孟加拉国多元城市公共初级保健中改善糖尿病和高血压护理的卫生系统干预的影响、覆盖和实施：一项研究方案DOI: 10.1136/bmjopen-2025-104331
BMJ open IF: 02.300Volume 16, Issue 4No.51Evaluation of an education intervention to support genomics research participation: a community-based pre-post study among participants under-represented in diabetes genomics research支持基因组学研究参与的教育干预评估：一项在糖尿病基因组学研究中代表性不足的参与者中开展的社区前后对照研究DOI: 10.1136/bmjopen-2025-100157
J Dr Nurs Pract IF: 00.200Ahead of Print.No.52Increasing Type 2 Diabetes Screening and Treatment Rates at a Community Clinic在社区诊所提高2型糖尿病筛查和治疗率DOI: 10.1891/JDNP-2024-0063
Canadian family physician IF: 02.400Volume 70, Issue 1No.53Prise en charge du diabète de type 2 chez les patients fragiles脆弱患者2型糖尿病的管理DOI: 10.46747/cfp.7001e10
Diabetes & metabolic syndrome IF: 03.400Ahead of Print.No.54The effect of baseline prediabetes on the relation between lipoprotein (a) and incident type 2 diabetes mellitus and cardiovascular outcomes: observations from the UK-Biobank基线糖尿病前期状态对脂蛋白(a)与2型糖尿病及心血管结局关系的影响：来自英国生物银行的研究DOI: 10.1016/j.dsx.2026.103422
Kidney international IF: 12.600Ahead of Print.No.55A MEF2C transcription factor network regulates proliferation of glomerular endothelial cells in diabetic kidney diseaseMEF2C转录因子网络调控糖尿病肾病中肾小球内皮细胞增殖DOI: 10.1016/j.kint.2026.03.020
Environmental pollution IF: 07.300Ahead of Print.No.56Prenatal Exposure to Gas Stoves, Mold, and Water Damage: Associations With Gestational Duration and Fetal Growth in the ECHO Cohort产前暴露于燃气灶、霉菌和水损：与ECHO队列中妊娠时长和胎儿生长的关联DOI: 10.1016/j.envpol.2026.128219
Social science & medicine IF: 05.000Ahead of Print.No.57Using a life table to quantify survival-related selection bias in studies of racial health disparities使用生命表量化种族健康差异研究中的生存相关选择偏倚DOI: 10.1016/j.socscimed.2026.119341
Biosensors & bioelectronics IF: 10.500Ahead of Print.No.58Real-time, label-free impedimetric monitoring of insulin secretion from three-dimensional stem cell-derived islets实时无标记阻抗监测三维干细胞来源胰岛的胰岛素分泌DOI: 10.1016/j.bios.2026.118720
Atención primaria IF: 01.600Ahead of Print.No.59[Effectiveness of telemedicine interventions for the management of gestational diabetes in primary care centers]远程医疗干预在基层医疗中心管理妊娠期糖尿病中的有效性DOI: 10.1016/j.aprim.2026.103504
Diabetes & metabolism IF: 04.700Ahead of Print.No.60Bone phenotype in familial partial lipodystrophy type 2: insulin resistance and sclerostin家族性部分脂肪营养不良2型中的骨表型：胰岛素抵抗与硬骨素DOI: 10.1016/j.diabet.2026.101762
Eye IF: 03.200Ahead of Print.No.61Risk of cerebrovascular and cardiovascular outcomes in patients with an ICD code for ocular migraine眼型偏头痛患者脑血管和心血管结局的风险DOI: 10.1038/s41433-026-04479-0
Scientific reports IF: 03.900Ahead of Print.No.62Reimbursement restrictions reduce liver fibrosis screening in adults with diabetes in Ontario: a population-based interrupted time series analysis报销限制降低了安大略省糖尿病成人患者的肝纤维化筛查率：一项基于人群的间断时间序列分析DOI: 10.1038/s41598-026-48600-5
J Diabetes Complications IF: 03.100Ahead of Print.No.63Association between chronic low-grade inflammation and metabolic syndrome and their impact on the risk of coronary artery disease in type 1 diabetes1型糖尿病中慢性低度炎症与代谢综合征的关联及其对冠状动脉疾病风险的影响DOI: 10.1016/j.jdiacomp.2026.109331
BMJ open IF: 02.300Volume 16, Issue 4No.64Prevent 6:1 trial: pI rotocol for a feasibility trial of a 6:1 intermittent diet for weight gain prevention in women at increased risk of breast cancerPrevent 6:1试验：6:1间歇性饮食预防乳腺癌高风险女性体重增加的可行性试验方案DOI: 10.1136/bmjopen-2025-113204
Trends Endocrinol Metab IF: 12.600Ahead of Print.No.65Neuroprotective strategies for cognitive decline in type 2 diabetes2型糖尿病认知衰退的神经保护策略DOI: 10.1016/j.tem.2026.04.003
Endocrinol Diabetes Metab Case Rep IF: 00.700Volume 2026, Issue 2No.66Pheochromocytoma and primary hyperparathyroidism: a very rare association in a neurofibromatosis type 1 patient unmasked by Takotsubo syndrome嗜铬细胞瘤与原发性甲状旁腺功能亢进症：Takotsubo综合征揭示的1型神经纤维瘤病患者中极为罕见的关联DOI: 10.1530/EDM-25-0109
Internal medicine IF: 01.100Ahead of Print.No.67Impact of Tirzepatide on FIB-4 in Patients with Type 2 Diabetes: A Comparison between GLP-1RA-naïve and GLP-1RA Switch Initiation in a Retrospective Cohort替尔泊肽对2型糖尿病患者FIB-4的影响：GLP-1RA初治与转换治疗的回顾性队列比较DOI: 10.2169/internalmedicine.6886-25
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.68Efficacy and Safety of Pregabalin and Alpha-Lipoic Acid Combination in Patients With Painful Diabetic Peripheral Neuropathy: A Randomized, Open-Label, Non-Inferiority, Phase IV Clinical Trial and Subgroup Analysis (OPTIMUM Study)普瑞巴林与α-硫辛酸联合治疗痛性糖尿病周围神经病变患者的有效性和安全性：一项随机、开放标签、非劣效性、IV期临床试验及亚组分析（OPTIMUM研究）DOI: 10.1111/dom.70795
Domestic animal endocrinology IF: 02.100Ahead of Print.No.69Ertugliflozin decreases the insulin spike in non-insulin dysregulated standardbred horses following intra-articular triamcinolone administration艾托格列净降低非胰岛素调节异常的标准马关节内注射曲安奈德后的胰岛素峰值DOI: 10.1016/j.domaniend.2026.107016
Annals of family medicine IF: 05.100Ahead of Print.No.70Underuse of Pharmacologic Therapies for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Before Specialist Evaluation专科评估前肌痛性脑脊髓炎/慢性疲劳综合征药物治疗使用不足DOI: 10.1370/afm.250266
Nature IF: 48.500Ahead of Print.No.71A cell atlas charts the immune architecture of diabetic kidney disease细胞图谱揭示糖尿病肾病的免疫结构DOI: 10.1038/d41586-026-01177-5
Cardiovascular Diabetology IF: 10.600Ahead of Print.No.72Cardiovascular–kidney–metabolic syndrome: a comprehensive review of pathophysiology, epidemiology, diagnosis, and management心血管-肾脏-代谢综合征：病理生理学、流行病学、诊断和管理的全面综述DOI: 10.1186/s12933-026-03177-1
JMIR serious games IF: 04.100Volume 14, Issue No.73User Experience of a Virtual Reality-Based Treadmill for Children With a Chronic Disease Affecting Physical Health: Cross-Sectional Feasibility Study基于虚拟现实的跑步机对患有影响身体健康的慢性疾病儿童的用户体验：横断面可行性研究DOI: 10.2196/82953
Hormone research in p?diatrics : IF: 02.700Ahead of Print.No.74U.S. Adolescents of Asian Ethnicity have Higher Risk of Polycystic Ovary Syndrome美国亚裔青少年患多囊卵巢综合征风险更高DOI: 10.1159/000552156
Journal of obesity IF: 03.900Volume 2026, Issue 1No.75Prevalence and Factors Associated With Severe Obesity Among U.S. Adults: A Cross-Sectional Study美国成年人重度肥胖的患病率及相关因素：一项横断面研究DOI: 10.1155/jobe/3831008
JMIR human factors IF: 03.000Volume 13, Issue No.76Continuous Glucose Monitoring for Personalized Nutrition in Real-World Vively App Users: Retrospective Observational Study真实世界Vively应用用户中持续葡萄糖监测用于个性化营养的回顾性观察研究DOI: 10.2196/80734
JMIR human factors IF: 03.000Volume 13, Issue No.77Evaluation of Combined Educational Methods on Motivational Interviewing for Final-Year Medical Students: Mixed Methods Study联合教育方法对医学生动机性访谈能力的影响：混合方法研究DOI: 10.2196/89126
Annals of Cardiac Anaesthesia IF: 01.300Ahead of Print.No.78Incidence and Associated Factors of ST-Segment Changes in Noncardiac Surgery Under General Anesthesia全身麻醉下非心脏手术ST段改变的发生率及关联因素DOI: 10.4103/aca.aca_243_25
Zh Nevrol Psikhiatr Im S S KorsakovaVolume 126, Issue 4. Vyp. 2No.79[Transitional cognitive syndrome: Reconsidered classification of cognitive disorders]过渡性认知综合征：认知障碍分类的再思考DOI: 10.17116/jnevro202612604247
PloS one IF: 02.600Volume 21, Issue 4No.80Catastrophic health care expenditure among older people with non-communicable diseases in 11 European Union Member States11个欧盟成员国患有非传染性疾病的老年人灾难性医疗支出研究DOI: 10.1371/journal.pone.0346341
Einstein IF: 01.100Volume 24, Issue No.81Factors associated with sleep quality and duration in mothers of children with autism spectrum disorder: a cross-sectional study自闭症谱系障碍儿童母亲睡眠质量与时长相关因素：一项横断面研究DOI: 10.31744/einstein_journal/2026AO2004
Clin J Am Soc Nephrol IF: 07.100Ahead of Print.No.82SGLT2 Inhibitors versus GLP-1 Receptor Agonists Type 2 Diabetes, The Kidney ConundrumSGLT2抑制剂与GLP-1受体激动剂在2型糖尿病中的比较：肾脏难题DOI: 10.2215/CJN.0000001068
Zh Nevrol Psikhiatr Im S S KorsakovaVolume 126, Issue 4. Vyp. 2No.83[Current evidence-based approaches to the treatment of vascular cognitive impairment]当前血管性认知障碍治疗的循证方法DOI: 10.17116/jnevro202612604278
PloS one IF: 02.600Volume 21, Issue 4No.84Spatial and temporal modeling of breast cancer mortality in Kansas: An R-INLA approach堪萨斯州乳腺癌死亡率时空建模：基于R-INLA方法DOI: 10.1371/journal.pone.0347607
PloS one IF: 02.600Volume 21, Issue 4No.85Implications of acute change in estimated Glomerular Filtration Rate (eGFR) for the effect of sodium-glucose cotransporter-2 inhibitors (SGLT-2i) on long-term endpoints估算肾小球滤过率急性变化对钠-葡萄糖协同转运蛋白2抑制剂长期终点效应的影响DOI: 10.1371/journal.pone.0347741
AIDS IF: 03.100Volume 40, Issue 6No.86SGLT2 inhibitor dapagliflozin attenuates HIV-associated cardiac fibrosis, steatosis and diastolic dysfunction in a mouse model via inhibition of TGFβ signalingSGLT2抑制剂达格列净通过抑制TGFβ信号减轻HIV相关的心脏纤维化、脂肪变性和舒张功能障碍（小鼠模型）DOI: 10.1097/QAD.0000000000004464
The Lancet HIV IF: 13.000Volume 13, Issue 5, Page e287-e356No.87Incidence, risk factors, and cardiovascular impact of hypertension in people with HIV: a secondary analysis of the REPRIEVE trialHIV感染者高血压的发病率、危险因素及心血管影响：REPRIEVE试验的二次分析DOI: 10.1016/S2352-3018(26)00036-6
PloS one IF: 02.600Volume 21, Issue 4No.88Criterion validity and divergent risk profiles of long-term opioid therapy across medicare and medicaid长期阿片类药物治疗在Medicare和Medicaid中的标准效度及风险特征差异DOI: 10.1371/journal.pone.0347943
JMIR research protocols IF: 01.500Volume 15, Issue No.89The Current Landscape of Remote Patient Monitoring Regarding Diabetes Mellitus and Hypoglycemia: Protocol for a Scoping Review远程患者监测在糖尿病和低血糖管理中的现状：范围综述方案DOI: 10.2196/88197
Science advances IF: 12.500Volume 12, Issue 18No.90IRS4 is a PI3K-activating cancer dependency up-regulated through DNA rearrangements or epigenetic mechanisms in multiple solid tumorsIRS4是一种通过DNA重排或表观遗传机制在多种实体瘤中上调的PI3K激活型癌症依赖性基因DOI: 10.1126/sciadv.aeb3503
Annals of Cardiac Anaesthesia IF: 01.300Ahead of Print.No.91Incidence and Predictors of Postoperative Atrial Fibrillation Following Cardiac Surgery: A Systematic Review心脏手术后新发房颤的发生率及预测因素：一项系统综述DOI: 10.4103/aca.aca_285_25
Heart Rhythm IF: 05.700Ahead of Print.No.92Identification of Clinical Risk Factors for Arrhythmia Recurrence in Atrial Fibrillation Patients Undergoing Catheter Ablation: A Systematic review and Meta-analysis房颤导管消融术后心律失常复发的临床危险因素识别：系统评价与荟萃分析DOI: 10.1016/j.hrthm.2026.04.046
Heart IF: 04.400Ahead of Print.No.93Derivation and validation of a prediction model for long-term mortality in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention: the PREDICT-ST-Elevation Myocardial Infarction scoreST段抬高型心肌梗死患者经皮冠状动脉介入治疗后长期死亡率预测模型的推导与验证：PREDICT-STEMI评分DOI: 10.1136/heartjnl-2026-327811
Indian Journal of Ophthalmology IF: 01.800Volume 74, Issue 5No.94Biosimilar anti-vascular endothelial growth factor agents: Clinical outcomes, safety, and cost-effectiveness in India生物类似药抗血管内皮生长因子制剂在印度的临床结局、安全性和成本有效性DOI: 10.4103/IJO.IJO_3222_25
JAMA dermatology IF: 11.000Ahead of Print.No.95Deuterated Pentoxifylline Analog in the Treatment of Necrobiosis Lipoidica: A Nonrandomized Clinical Trial氘代己酮可可碱类似物治疗类脂质渐进性坏死：一项非随机临床试验DOI: 10.1001/jamadermatol.2026.0863
Lasers in medical science IF: 02.400Volume 41, Issue 1No.96Photobiomodulation combined with dynamic thermal imaging as a diagnostic tool for chronic leg ulcers光生物调节联合动态热成像作为慢性腿部溃疡的诊断工具DOI: 10.1007/s10103-026-04878-5
Am J Physiol Heart Circ Physiol IF: 04.100Ahead of Print.No.97Myeloid transglutaminase 2 regulates Treg-Th17 balance in a female model of Angiotensin II-induced hypertension and vascular stiffening髓系转谷氨酰胺酶2在血管紧张素II诱导的高血压和血管硬化雌性模型中调节Treg-Th17平衡DOI: 10.1152/ajpheart.00095.2026
Journal of fluorescence IF: 03.100Ahead of Print.No.98Design and Optimization of a Glucose Fluorescence Nano-biosensor Based on Graft Copolymer of Poly(acrylic acid)-co-(vinyl phenyl boronic acid)-g-gelatin to Modify CdTe/TGA QDs基于聚丙烯酸-co-乙烯基苯硼酸-g-明胶接枝共聚物修饰CdTe/TGA量子点的葡萄糖荧光纳米生物传感器的设计与优化DOI: 10.1007/s10895-026-04763-y
International ophtalmology IF: 01.400Volume 46, Issue 1No.99Clinical and demographic characteristics of glaucoma patients in Kingston, Jamaica牙买加金斯敦青光眼患者的临床和人口学特征DOI: 10.1007/s10792-026-04020-y
J Pediatr Endocrinol Metab IF: 01.000Ahead of Print.No.100Psychosocial adaptation of parents of children with type 1 diabetes: a cross-sectional study1型糖尿病患儿父母的心理社会适应：一项横断面研究DOI: 10.1515/jpem-2026-0061
J Pediatr Endocrinol Metab IF: 01.000Ahead of Print.No.101Age and sexual maturation at Spermarche in boys with Laron syndromeLaron综合征男孩首次遗精的年龄与性成熟DOI: 10.1515/jpem-2026-0043
Advances in physiology education IF: 01.700Ahead of Print.No.102The Development and Impact of an Innovative Graduate Program To Promote Entry to Physiology-Related Careers: The Master of Health Science in Medical Physiology创新研究生项目促进生理学相关职业发展的开发与影响：医学生理学健康科学硕士DOI: 10.1152/advan.00060.2026
Diabetes care IF: 16.600Ahead of Print.No.103Misguided Brushes of a Pen Continue to Dismantle and Destroy Biomedical Research in the United States: We Can No Longer Afford Complacency and Fear. We Must All Act Now!错误的笔触持续瓦解和摧毁美国生物医学研究：我们不能再容忍自满与恐惧，必须立即行动！DOI: 10.2337/dci26-0068
Metab Syndr Relat Disord IF: 01.700Ahead of Print.No.104Serum Proenkephalin A as a Marker of Renal Dysfunction and Glycemic Status in Diabetic Nephropathy血清前脑啡肽A作为糖尿病肾病肾功能不全和血糖状态的标志物DOI: 10.1177/15578518261444701
Pancreas IF: 01.700Ahead of Print.No.105Predictive Power of Imaging: Assessing Parenchymal Fibrosis in Pediatric Chronic Pancreatitis影像学预测能力：评估儿童慢性胰腺炎实质纤维化DOI: 10.1097/MPA.0000000000002658
Pol Arch Intern Med IF: 04.700Volume 136, Issue 4No.106Corrections: Assessment of the type 2 diabetes risk using the Finnish Diabetes Risk Score questionnaire, and its predictors at the population level in Poland更正：使用芬兰糖尿病风险评分问卷评估2型糖尿病风险及其在波兰人群水平上的预测因素DOI: 10.20452/pamw.17283
Medical care research and review IF: 02.200Ahead of Print.No.107Defining the Social Needs Service Cascade: Evidence From A Multistakeholder Qualitative Study定义社会需求服务级联：来自多利益相关者定性研究的证据DOI: 10.1177/10775587261439173
Global spine journal IF: 03.000Ahead of Print.No.108Incidence and Risk Factors for 30- and 90-day Reoperations Following Biportal Endoscopic Lumbar Discectomy for Single-Level Lumbar Disc Herniations单节段腰椎间盘突出症双通道内镜下椎间盘切除术后30天和90天再手术的发生率及危险因素DOI: 10.1177/21925682261448186
Plast Reconstr Surg IF: 03.400Ahead of Print.No.109Massive Weight Loss with Bariatric Surgery and GLP-1RA Therapy Predicts Postoperative Complications Following Abdominal Body Contouring减重手术与GLP-1RA治疗导致的巨大体重下降预示腹部塑形术后并发症DOI: 10.1097/PRS.0000000000013015
Inflammopharmacology IF: 05.300Ahead of Print.No.110Dapagliflozin mitigates acute pancreatitis induced by L-arginine in Rats through modulation of TLR-4/NF-κB/NLRP3 pathway: integrated biochemical, histopathological, and in silico study达格列净通过调节TLR-4/NF-κB/NLRP3通路减轻L-精氨酸诱导的大鼠急性胰腺炎：整合生化、组织病理学和计算机模拟研究DOI: 10.1007/s10787-026-02190-w
Am J Physiol Renal Physiol IF: 03.400Ahead of Print.No.111Dapagliflozin ameliorates high-fat diet-induced, megalin-mediated autolysosomal dysfunction in proximal tubules via suppression of megalin-dependent endocytosis达格列净通过抑制megalin依赖性内吞改善高脂饮食诱导的近端肾小管megalin介导的自噬溶酶体功能障碍DOI: 10.1152/ajprenal.00448.2025
Archives of osteoporosis IF: 02.800Volume 21, Issue 1No.112Bone health in young adults with inflammatory arthritis: assessment of associated factors of low bone mineral density年轻成人炎症性关节炎患者的骨骼健康：低骨密度相关因素的评估DOI: 10.1007/s11657-026-01710-z
JAMA psychiatry IF: 17.100Ahead of Print.No.113Semaglutide and Effort-Based Decision-Making in Major Depressive Disorder: A Randomized Clinical Trial司美格鲁肽与重度抑郁症中基于努力的决策：一项随机临床试验DOI: 10.1001/jamapsychiatry.2026.0594
Irish journal of medical science IF: 01.600Ahead of Print.No.114Associations of Mediterranean, DASH, and MIND diet adherence with metabolic parameters in individuals with type 2 diabetes mellitus: a cross-sectional study地中海饮食、DASH饮食和MIND饮食依从性与2型糖尿病患者代谢参数的相关性：一项横断面研究DOI: 10.1007/s11845-026-04415-x
J Egypt Public Health Assoc IF: 02.500Volume 101, Issue 1No.115Psychometric evaluation of the Arabic brief forms of the diabetes distress scale in Egyptian patients with type II diabetes阿拉伯语简短版糖尿病痛苦量表在埃及2型糖尿病患者中的心理测量学评估DOI: 10.1186/s42506-026-00216-3
Retinal cases & brief reportsAhead of Print.No.116Atypical (Three-Quadrant) Central Retinal Vein Occlusion: A Report of two cases and review of literature非典型（三象限）视网膜中央静脉阻塞：两例报告及文献综述DOI: 10.1097/ICB.0000000000001929
Nursing research IF: 02.200Ahead of Print.No.117Perceived Family Support and Treatment Adherence in Older Adults With Type 2 Diabetes老年2型糖尿病患者感知到的家庭支持与治疗依从性DOI: 10.1097/NNR.0000000000000914
Wound repair and regeneration IF: 03.400Volume 34, Issue 3No.118A First-In-Human Study of Pyroligneous Extract, the Biomaterial Derived From Pyrolytic Palm Kernel Shell Wood Vinegar as a Novel Wound Healing Aid on Diabetic Foot Ulcer热解棕榈仁壳木醋液衍生的生物材料——焦木提取物作为糖尿病足溃疡新型伤口愈合辅助剂的首次人体研究DOI: 10.1111/wrr.70166
Multiple sclerosis : IF: 05.000Ahead of Print.No.119Use of semaglutide and tirzepatide among people with multiple sclerosis司美格鲁肽和替尔泊肽在多发性硬化患者中的使用情况DOI: 10.1177/13524585261442033
Food science of animal resources IF: 03.700Volume 44, Issue 1No.120Oral Administration of Lactilactobacillus curvatus LB-P9 Promotes Hair Regeneration in Mice口服弯曲乳杆菌LB-P9促进小鼠毛发再生DOI: 10.5851/kosfa.2023.e74
Clinical transplantation IF: 01.900Volume 40, Issue 5No.121Hypoglycemia Occurrence and Risk Factors in Insulin Independent Patients After Total Pancreatectomy With Islet Autotransplantation全胰腺切除联合胰岛自体移植后胰岛素独立患者低血糖的发生率及危险因素DOI: 10.1111/ctr.70549
Physiology IF: 10.300Ahead of Print.No.122Multicellular Crosstalk and Therapeutic Vaccines in Heart Failure心力衰竭中的多细胞串扰与治疗性疫苗DOI: 10.1152/physiol.00007.2026
JAMA Network Open IF: 09.700Volume 9, Issue 4No.123Hypertrophic Cardiomyopathy and Risk of Out-of-Hospital Cardiac Arrest肥厚型心肌病与院外心脏骤停风险DOI: 10.1001/jamanetworkopen.2026.9673
Am J Physiol Regul Integr Comp Physiol IF: 02.300Ahead of Print.No.124B-Raf is required for normal murine cardiac development and functionB-Raf对小鼠正常心脏发育和功能是必需的DOI: 10.1152/ajpregu.00063.2025
The Prostate IF: 02.500Ahead of Print.No.125Prostate Cancer, Genetic Susceptibility, and Risk of Chronic Non-Urological Complications前列腺癌、遗传易感性与慢性非泌尿系统并发症风险DOI: 10.1002/pros.70190
J Eval Clin Pract IF: 02.100Volume 32, Issue 4No.126A Remote Chronic Disease Management Program to Improve Cardiovascular and Metabolic Outcomes in a Diverse Community-Based Diabetic Population: Study Design of the TAMIS Trial远程慢性病管理项目改善多样化社区糖尿病人群心血管和代谢结局：TAMIS试验研究设计DOI: 10.1111/jep.70456
Cell biochemistry and biophysics IF: 02.500Ahead of Print.No.127Distinct Antibody Signatures to Human Endogenous Retroviruses and Mycobacterium Paratuberculosis in Newly Diagnosed Tunisian Type 1 Diabetes Patients新诊断突尼斯1型糖尿病患者中人内源性逆转录病毒和副结核分枝杆菌的独特抗体特征DOI: 10.1007/s12013-026-02068-2
Journal of Human Hypertension IF: 03.400Ahead of Print.No.128Consensus on the management of hypertension in individuals with diabetes by Asian-Pacific Society of hypertension (APSH) & Diabetes Asia Study Group (DASG).亚太高血压学会与糖尿病亚洲研究组关于糖尿病患者高血压管理的共识DOI: 10.1038/s41371-026-01150-9
JAMA Cardiology IF: 14.100Ahead of Print.No.129Timeliness of Transthyretin Cardiac Amyloidosis Diagnosis in the Medicare Population医疗保险人群中转甲状腺素蛋白心脏淀粉样变性诊断的及时性DOI: 10.1001/jamacardio.2026.0833
JACC IF: 22.300Ahead of Print.No.130Development and Validation of a Clinical Polygenic Risk Report in U.S.-Based Health Systems for 8 Cardiovascular Conditions美国医疗系统中8种心血管疾病临床多基因风险报告的开发与验证DOI: 10.1016/j.jacc.2026.03.035
Mol Cell Biochem IF: 03.700Ahead of Print.No.131Elevated placental inflammation as a mediator of adverse outcomes in gestational diabetes mellitus胎盘炎症升高作为妊娠期糖尿病不良结局的介导因素DOI: 10.1007/s11010-026-05561-7
Irish journal of medical science IF: 01.600Ahead of Print.No.132Reduced fetal MAPSE and TAPSE in gestational diabetes mellitus: a prospective case-control study妊娠期糖尿病胎儿二尖瓣环收缩期位移与三尖瓣环收缩期位移降低：一项前瞻性病例对照研究DOI: 10.1007/s11845-026-04426-8
Soc Psychiatry Psychiatr Epidemiol IF: 03.500Ahead of Print.No.133Association between maternal pregnancy complications and long-term depressive and anxiety disorders: evidence from the UK millennium cohort study母体妊娠并发症与长期抑郁和焦虑障碍的关联：来自英国千禧队列研究的证据DOI: 10.1007/s00127-026-03094-4
JAHA IF: 05.300Ahead of Print.No.134Acute Impact of Transcatheter Edge-to-Edge Repair of Tricuspid Regurgitation on Right Ventricular Hemodynamics经导管缘对缘修复三尖瓣反流对右心室血流动力学的急性影响DOI: 10.1161/JAHA.125.047560
Endokrynologia Polska IF: 02.100Volume 77, Issue 2No.135Eradicating hyperandrogenism? Hormonal changes following Helicobacter pylori eradication in women with polycystic ovary syndrome: an observational case series根除幽门螺杆菌后多囊卵巢综合征女性的激素变化：一项观察性病例系列研究DOI: 10.5603/ep.110428
Saudi pharmaceutical journal IF: 03.400Volume 34, Issue 2No.136Efficacy and safety of pharmacological and procedural interventions in the management of hypertriglyceridemia-induced acute pancreatitis: a systematic review药物和介入干预治疗高甘油三酯血症诱导的急性胰腺炎的有效性和安全性：一项系统评价DOI: 10.1007/s44446-026-00078-y
Kaohsiung J Med Sci IF: 03.100Ahead of Print.No.137Efficacy of CPAP Therapy on Liver Steatosis and Insulin Resistance in Fatty Liver Patients With Obstructive Sleep Apnea: A 4-Year Follow-Up Cohort StudyCPAP治疗对阻塞性睡眠呼吸暂停合并脂肪性肝病患者肝脏脂肪变性和胰岛素抵抗的有效性：一项4年随访队列研究DOI: 10.1002/kjm2.70222
JAHA IF: 05.300Ahead of Print.No.138Glucose-6-Phosphate Dehydrogenase Modifies the Impact of Glucose on Arterial Aging in A Sex-Specific Manner葡萄糖-6-磷酸脱氢酶以性别特异性方式调节葡萄糖对动脉老化的影响DOI: 10.1161/JAHA.125.045538
JAMA IF: 55.000Ahead of Print.No.139Pigmentary Changes That Developed During Pregnancy妊娠期色素沉着变化DOI: 10.1001/jama.2026.2928
Rev Endocr Metab Disord IF: 08.000Ahead of Print.No.140Hypothalamic regulation of energy homeostasis: Quo vadis下丘脑对能量稳态的调控：何去何从DOI: 10.1007/s11154-026-10042-9
Obesity surgery IF: 03.100Ahead of Print.No.141Food Consumption by Processing Levels in Adults Two or More Years After Sleeve Gastrectomy: Associations with Surgical Outcomes and Eating Behaviors袖状胃切除术后两年及以上成年人按加工级别分类的食物消费：与手术结局和饮食行为的关联DOI: 10.1007/s11695-026-08582-9
Cell biochemistry and biophysics IF: 02.500Ahead of Print.No.142Effects of Diet-Induced Obesity and Exercise Intervention on Testicular Germ Cell Health: Modulation of SIRT1/FoxO1 and SIRT1/PGC-1α Signaling Axes饮食诱导肥胖与运动干预对睾丸生殖细胞健康的影响：SIRT1/FoxO1和SIRT1/PGC-1α信号轴的调节DOI: 10.1007/s12013-026-02076-2
BJS open IF: 04.500Volume 10, Issue 2No.143Sleeve gastrectomy versus Roux-en-Y-gastric bypass in patients with body mass index over 50 kg/m2: international multicentre cohort袖状胃切除术与Roux-en-Y胃旁路术在体重指数超过50 kg/m²患者中的比较：国际多中心队列研究DOI: 10.1093/bjsopen/zrag028
J Clin Pharmacol IF: 02.300Volume 66, Issue 5No.144Assessment of the Drug-Drug Interaction Potential of Lotiglipron (PF-07081532) with Midazolam, Omeprazole, Dabigatran, Rosuvastatin, and the Oral Contraceptives Levonorgestrel and Ethinyl Estradiol评估Lotiglipron（PF-07081532）与咪达唑仑、奥美拉唑、达比加群、瑞舒伐他汀以及口服避孕药左炔诺孕酮和炔雌醇的药物相互作用潜力DOI: 10.1002/jcph.70158
Health informatics journal IF: 02.300Volume 32, Issue 2No.145An informatics-based data-led prioritization strategy to facilitate objective and equitable care for an ethnically diverse urban cohort of people with type 1 diabetes: A proof-of-concept study基于信息学的数据主导优先排序策略：为种族多样化的城市1型糖尿病患者群体提供客观公平护理的概念验证研究DOI: 10.1177/14604582261436276
Crit Rev Food Sci Nutr IF: 08.800Ahead of Print.No.146A scoring system for validity assessment of biomarkers of food intake食物摄入生物标志物有效性评估评分系统DOI: 10.1080/10408398.2026.2633561
Nutrition and health IF: 01.400Ahead of Print.No.147Influence of autonomic function on the thermic effect of food and postprandial insulin sensitivity in individuals with obesity, submitted to a test meal with or without ultra-processed foods: Secondary analysis of a randomized trial自主神经功能对肥胖个体食物热效应和餐后胰岛素敏感性的影响：一项随机试验的二次分析DOI: 10.1177/02601060261446525
Nutrition reviews IF: 04.900Ahead of Print.No.148Methyl Donor Nutrient Intake as a Modulator of the Association between FTO Gene Variants and BMI: A Systematic Review with Meta-Analysis and Meta-Regression甲基供体营养素摄入作为FTO基因变异与体重指数之间关联的调节因素：系统综述、荟萃分析和荟萃回归DOI: 10.1093/nutrit/nuag035
Journal of human lactation : IF: 01.800Ahead of Print.No.149Linking Early Infant Growth With Milk-Derived Antibodies, Hormones, and Macronutrients During Exclusive Breastfeeding纯母乳喂养期间早期婴儿生长与母乳中抗体、激素和宏量营养素的关联DOI: 10.1177/08903344261430138
Open Heart IF: 02.800Volume 13, Issue 1No.150Are clinical improvements in anxiety or depression associated with improvement in walking fitness following a cardiac rehabilitation programme?心脏康复计划后焦虑或抑郁的临床改善是否与步行能力的改善相关？DOI: 10.1136/openhrt-2026-004051
Thyroid research IF: 01.800Volume 19, Issue 1No.151Measuring thyroid-stimulating hormone receptor antibodies using the IMMULITE(®) 2000 TSI assay is better than using the BRAHMS TRAK assay in an unselected clinical population, but both perform worse than expected: a real-world retrospective observational study在未经筛选的临床人群中，使用IMMULITE® 2000 TSI检测法测量促甲状腺激素受体抗体优于BRAHMS TRAK检测法，但两者表现均低于预期：一项真实世界回顾性观察研究DOI: 10.1186/s13044-026-00296-5
Int J Reprod Biomed IF: 01.800Volume 24, Issue 2No.152Therapeutic effects of Foeniculum vulgare and Achillea millefolium on ovarian function in a mouse model of polycystic ovary syndrome: An experimental study茴香和蓍草对多囊卵巢综合征小鼠模型卵巢功能的治疗作用：一项实验研究DOI: 10.18502/ijrm.v24i2.21053
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.153Molecular mechanisms of insulin resistance and altered carbohydrate metabolism in PCOS: a scoping review多囊卵巢综合征胰岛素抵抗与碳水化合物代谢改变的分子机制：一项范围综述DOI: 10.3389/fendo.2026.1810805
bioRxivVolume 2026, Issue No.154Distinct Molecular Mechanisms Regulate Feeding State-Dependent CO (2) Chemotaxis Plasticity During Different Life Stages in Caenorhabditis elegans不同生命阶段中进食状态依赖的CO2趋化可塑性的不同分子机制DOI: 10.64898/2026.02.06.704338
BMC research notes IF: 01.700Ahead of Print.No.155In vitro assessment of the impact of di(2-ethylhexyl) phthalate and its metabolites on the function and transcription of key glucose sensing proteins in a rat pancreatic β-cell line邻苯二甲酸二(2-乙基己基)酯及其代谢物对大鼠胰腺β细胞系关键葡萄糖感应蛋白功能和转录影响的体外评估DOI: 10.1186/s13104-026-07830-6
JACC: AdvancesVolume 5, Issue 5No.156Characteristics, Management, and Outcomes of Diabetes Subtypes in Patients With Cardiogenic Shock心源性休克患者糖尿病亚型的特征、管理及主要终点DOI: 10.1016/j.jacadv.2026.102766
Diabetology & metabolic syndrome IF: 03.900Ahead of Print.No.157Prognostic value of advanced imaging biomarkers for the progression of diabetic retinopathy: a systematic review先进影像生物标志物对糖尿病视网膜病变进展的预后价值：一项系统评价DOI: 10.1186/s13098-026-02159-3
Current obesity reports IF: 11.000Volume 15, Issue 1No.158The Epidemiology of the Global Syndemic in Africa: New Evidence and Key Insights非洲全球共病流行病学：新证据与关键见解DOI: 10.1007/s13679-026-00717-4
Frontiers in health services IF: 02.700Volume 6, Issue No.159Therapeutic intensity and patient-reported outcomes among heart failure patients in a pharmacist-led medication therapy adherence clinic program in Malaysia马来西亚药师主导的药物治疗依从性门诊项目中心力衰竭患者的治疗强度与患者报告结局DOI: 10.3389/frhs.2026.1784432
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.160Acromegalic features and hypoglycemia: Doege-Potter syndrome肢端肥大症特征与低血糖：Doege-Potter综合征DOI: 10.22088/cjim.17.1.205
JCEM case reportsVolume 4, Issue 5No.161A rare case of dual hormone-secreting pulmonary neuroendocrine tumor causing concurrent Cushing syndrome and acromegaly一例罕见的双重激素分泌性肺神经内分泌肿瘤导致库欣综合征和肢端肥大症并存DOI: 10.1210/jcemcr/luag092
Journal of Hypertension IF: 04.100Volume 44, Issue 6No.162Response to letter 'Sex-specific associations between TyG index and emotional states'对《TyG指数与情绪状态的性别特异性关联》一信的回复DOI: 10.1097/HJH.0000000000004289
Int J Eat Disord IF: 04.300Ahead of Print.No.163Sex Differences in Social, Health, and Lifestyle Characteristics Associated With Binge-Eating Behaviors: Results From a French National Random Population-Based Study与暴食行为相关的社会、健康和生活方式特征的性别差异：基于法国全国随机人群研究的结果DOI: 10.1002/eat.70113
J Integr Neurosci IF: 02.700Volume 25, Issue 4No.164Lipid Ratio Biomarkers as Protective Factors for Depressive Symptoms in Newly Diagnosed Metabolic Syndrome: Evidence From Regression Modeling脂质比值生物标志物作为新诊断代谢综合征患者抑郁症状的保护因素：来自回归模型的证据DOI: 10.31083/JIN49628
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.165The association between appendicular skeletal muscle index and liver steatosis and fibrosis: A cross-sectional study四肢骨骼肌指数与肝脏脂肪变性和纤维化的关联：一项横断面研究DOI: 10.22088/cjim.17.1.113
Front Sports Act Living IF: 02.600Volume 8, Issue No.166Physiological and cortical determinants of exercise tolerance in sedentary women with obesity久坐肥胖女性运动耐量的生理和皮层决定因素DOI: 10.3389/fspor.2026.1771921
Int J Womens Health IF: 02.600Volume 18, Issue No.167Comparison of Surgical Outcomes Among Open, Laparoscopic, and Robotic Surgeries in Women with Obesity Diagnosed with Endometrial Cancer: Results from a Quaternary Hospital in Thailand肥胖子宫内膜癌患者开腹、腹腔镜与机器人手术结局比较：泰国一家四级医院的结果DOI: 10.2147/IJWH.S598487
JBMR plus IF: 02.400Volume 10, Issue 5No.168Pain medication use in patients with X-linked hypophosphatemia treated with burosumab: a retrospective real-world study布罗索尤单抗治疗X连锁低磷血症患者的止痛药使用：一项回顾性真实世界研究DOI: 10.1093/jbmrpl/ziag047
Journal of affective disorders reportsVolume 24, Issue No.169Insights from deep learning models on new-onset anxiety in patients following bariatric metabolic surgery深度学习模型对减重代谢手术后新发焦虑的洞察DOI: 10.1016/j.jadr.2026.101061
Frontiers in psychology IF: 02.900Volume 17, Issue No.170Didactic adaptation of basketball in physical education to reduce anxiety and emotional eating in adolescent girls with obesity: a randomized controlled trial体育教育中篮球教学适应性改编对肥胖青少年女性焦虑和情绪性进食的影响：一项随机对照试验DOI: 10.3389/fpsyg.2026.1753266
Front Behav Neurosci IF: 02.900Volume 20, Issue No.171Revisiting food addiction in the era of GLP-1-based obesity pharmacotherapy via neural reward pathways linking feeding and substance use在基于GLP-1的肥胖药物治疗时代重新审视食物成瘾：通过连接进食与物质使用的神经奖赏通路DOI: 10.3389/fnbeh.2026.1805953
J Diabetes Investig IF: 03.000Ahead of Print.No.172Validation of the ST1RE risk engine in Chinese with type 1 diabetes and comparison with the JADE, RECODe, and UKPDS risk scoresST1RE风险引擎在中国1型糖尿病患者中的验证及与JADE、RECODe和UKPDS风险评分的比较DOI: 10.1111/jdi.70316
British journal of nutrition IF: 03.000Ahead of Print.No.173Patterns of dietary habits are associated with metabolic health status in adults膳食习惯模式与成人代谢健康状态相关DOI: 10.1017/S0007114526106722
Mol Nutr Food Res IF: 04.200Volume 70, Issue 9No.174Maternal Chrono-Nutrition and Placental DNA Methylation: The BiSC Study母亲时间营养与胎盘DNA甲基化：BiSC研究DOI: 10.1002/mnfr.70465
Lipids IF: 01.600Ahead of Print.No.175Hepatic Lipids as Molecular Targets in Obesity-Associated Insulin Resistance in Rodent Models: A Systematic Review and Meta-Analysis啮齿动物模型中肝脏脂质作为肥胖相关胰岛素抵抗的分子靶点：系统综述与荟萃分析DOI: 10.1002/lipd.70061
J Diabetes Investig IF: 03.000Ahead of Print.No.176Time in range during caloric restriction in type 2 diabetes with obesity肥胖2型糖尿病患者热量限制期间的血糖在目标范围内时间DOI: 10.1111/jdi.70308
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.177Indirect Comparative Efficacy and Safety of Tirzepatide Versus Oral Semaglutide for the Treatment of Overweight and Obesity替尔泊肽与口服司美格鲁肽治疗超重和肥胖的间接比较有效性和安全性DOI: 10.1111/dom.70773
British journal of nutrition IF: 03.000Ahead of Print.No.178Contribution of meals to energy and nutrient intakes and implication of skipping meals on nutritional status among primary schoolchildren in Malaysia马来西亚小学生膳食对能量和营养素摄入的贡献及不吃饭对营养状况的影响DOI: 10.1017/S0007114526107314
J Health Popul Nutr IF: 02.800Ahead of Print.No.179Malnutrition among men in Ghana: socio-demographic factors and rural-urban differences加纳男性营养不良：社会人口因素与城乡差异DOI: 10.1186/s41043-026-01325-7
Allergy IF: 12.000Ahead of Print.No.180Longitudinal Follow-Up of Gut and Salivary Microbiota in Children With Food Protein-Induced Enterocolitis Syndrome食物蛋白诱导性小肠结肠炎综合征患儿肠道和唾液微生物群的纵向随访DOI: 10.1111/all.70363
Frontiers in bioscience IF: 03.100Volume 31, Issue 4No.181Potential Application of HIF-PH Inhibitors to Treat Kidney DiseasesHIF-PH抑制剂治疗肾脏疾病的潜在应用DOI: 10.31083/FBL47718
Frontiers in bioscience IF: 03.100Volume 31, Issue 4No.182The Gut-Lung Axis, Epigenetics and Respiratory Disease肠-肺轴、表观遗传学与呼吸系统疾病DOI: 10.31083/FBL48743
Revista de neurología IF: 00.800Volume 81, Issue 4No.183Peripheral Neuropathy: A Phenotype-Driven Review for Diagnosis and Management周围神经病变：基于表型的诊断与管理综述DOI: 10.31083/RN48384
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.184Investigating the effect of pirfenidone on lung CT scans in patients with severe COVID-19 Hospitalized at Shahid Sadoughi Hospital, Yazd, Iran吡非尼酮对重症COVID-19患者肺部CT扫描影响的研究DOI: 10.22088/cjim.17.1.163
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.185Detecting coronary artery disease among the individuals with left-sided dominant coronary circulation左侧优势型冠状动脉循环个体中冠状动脉疾病的检测DOI: 10.22088/cjim.17.1.173
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.186Association of interleukin-8 and neutrophil-to-lymphocyte ratio with clinical indices in diabetic nephropathy白细胞介素-8和中性粒细胞与淋巴细胞比值与糖尿病肾病临床指标的相关性DOI: 10.22088/cjim.17.1.191
Sleep AdvVolume 7, Issue 2No.187Using consumer sleep trackers for sleep extension interventions: retention, adherence, and user experiences使用消费者睡眠追踪器进行睡眠延长干预：保留率、依从性和用户体验DOI: 10.1093/sleepadvances/zpag025
Health science reports IF: 02.100Volume 9, Issue 5No.188How Pre-Pregnancy Weight and Polycystic Ovary Syndrome Impact Pregnancy Outcomes: A Population-Based Cohort Study孕前体重与多囊卵巢综合征对妊娠结局的影响：一项基于人群的队列研究DOI: 10.1002/hsr2.72088
Frontiers in ophthalmologyVolume 6, Issue No.189Use of preoperative swept-source optical coherence tomography in vitrectomy for advanced diabetic eye disease: a pilot study术前扫频源光学相干断层扫描在晚期糖尿病眼病玻璃体切除术中的应用：一项初步研究DOI: 10.3389/fopht.2026.1688660
Clin Med Insights Endocrinol Diabetes IF: 03.000Volume 19, Issue No.190Euthyroid Sick Syndrome Precipitated By Rapid Weight Loss Following Semaglutide Initiation: A Case Report司美格鲁肽治疗后快速减重诱发正常甲状腺病态综合征：一例病例报告DOI: 10.1177/11795514261443862
RSC advances IF: 04.600Volume 16, Issue 24No.191Bacterial metabolite-directed synthesis of biogenic TiO(2)-Zn nanocomposites: characterization and multifunctional biomedical evaluation细菌代谢物导向合成生物源TiO₂-Zn纳米复合材料：表征与多功能生物医学评价DOI: 10.1039/d6ra00881j
Frontiers in chemistry IF: 04.200Volume 14, Issue No.192Phytochemical profiling and multi-target pharmacological evaluation of Symphyotrichum squamatum unveils its potential as a source of antidiabetic and anti-inflammatory agentsSymphyotrichum squamatum的植物化学谱系及多靶点药理学评价揭示其作为抗糖尿病和抗炎药物来源的潜力DOI: 10.3389/fchem.2026.1734411
J Pharm Policy Pract IF: 02.500Volume 19, Issue 1No.193Asthma and chronic obstructive disease overlap (ACO), a systematic review of prevalence and co-morbidity factors based on diagnostic criteria哮喘与慢性阻塞性肺疾病重叠（ACO）：基于诊断标准的患病率和共病因素系统综述DOI: 10.1080/20523211.2026.2654490
J Pharm Policy Pract IF: 02.500Volume 19, Issue 1No.194The prevalence and predictor factors of urinary tract infection in type 2 diabetes mellitus patients receiving SGLT2 inhibitors in Qatar: A retrospective cohort study卡塔尔2型糖尿病患者使用SGLT2抑制剂后尿路感染的患病率及预测因素：一项回顾性队列研究DOI: 10.1080/20523211.2026.2645913
Frontiers in public health IF: 03.400Volume 14, Issue No.195Central adiposity outperforms disordered eating behavior in predicting type 2 diabetes risk in young adults: an explainable machine learning approach中心性肥胖在预测年轻人2型糖尿病风险方面优于饮食行为紊乱：一项可解释机器学习方法DOI: 10.3389/fpubh.2026.1778156
Frontiers in public health IF: 03.400Volume 14, Issue No.196Correction: Influence of the COVID-19 pandemic on chronic disease management among indigenous people in Canada更正：COVID-19大流行对加拿大原住民慢性病管理的影响DOI: 10.3389/fpubh.2026.1817733
Int J Microbiol IF: 03.200Volume 2026, Issue No.197Coevolution of Human Diet and Gut Microbiome: Implications for Nutrigenomics and Cross-Population Health人类饮食与肠道微生物组的共同进化：对营养基因组学和跨人群健康的影响DOI: 10.1155/ijm/5597426
Germs IF: 01.700Volume 16, Issue 1No.198Variety of Clostridioides difficile Ribotypes in CDI Patients in Las Vegas, NV内华达州拉斯维加斯CDI患者中艰难梭菌核糖体类型的多样性DOI: 10.3390/germs16010002
Curēus IF: 01.300Volume 18, Issue 3No.199Elevated Lipoprotein(a) and Cardiovascular Outcomes After Percutaneous Coronary Intervention: A Systematic Review经皮冠状动脉介入治疗后脂蛋白(a)升高与心血管结局：一项系统评价DOI: 10.7759/cureus.106009
Curēus IF: 01.300Volume 18, Issue 3No.200Early-Remitting Neonatal Diabetes in a Growth-Restricted Preterm Infant Requiring Insulin: A Case Report生长受限早产儿需胰岛素治疗的早期缓解型新生儿糖尿病：一例病例报告DOI: 10.7759/cureus.106025
Frontiers in physiology IF: 03.400Volume 17, Issue No.201Modulation of the serotonergic system restores oxidative balance and gene expression in the brain and heart of rats with obesity induced by overnutrition血清素系统调节恢复营养过剩诱导肥胖大鼠脑和心脏的氧化平衡与基因表达DOI: 10.3389/fphys.2026.1783080
Frontiers in medicine IF: 03.000Volume 13, Issue No.202Systemic strategies to prevent early diabetic retinopathy: targeting polyunsaturated fatty acid metabolism and eicosanoid signaling预防早期糖尿病视网膜病变的系统性策略：靶向多不饱和脂肪酸代谢和类花生酸信号DOI: 10.3389/fmed.2026.1802443
J Clin Exp DentVolume 18, Issue 3No.203Nonsurgical Periodontal Therapy for Diabetes Patients with Periodontal Disease非手术牙周治疗对伴有牙周病的糖尿病患者的疗效DOI: 10.4317/jced.63729
J Public Health ResVolume 15, Issue 2No.204Understanding community needs: Comprehensive analysis of the family adoption program conducted in coastal region of South India理解社区需求：印度南部沿海地区家庭收养计划的综合分析DOI: 10.1177/22799036261439972
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.205Relationship between apolipoprotein M levels and diabetic retinopathy in patients with type 2 diabetes mellitus2型糖尿病患者载脂蛋白M水平与糖尿病视网膜病变的关系DOI: 10.3389/fendo.2026.1809680
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.206Dermatologic outcomes associated with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a large-scale target trial emulation胰高血糖素样肽-1受体激动剂与2型糖尿病患者皮肤结局的关联：一项大规模目标试验模拟研究DOI: 10.3389/fendo.2026.1801203
Frontiers in digital health IF: 03.800Volume 8, Issue No.207ChatGPT for diabetes education: potential, accuracy, and accessibility in patient supportChatGPT在糖尿病教育中的应用：患者支持中的潜力、准确性与可及性DOI: 10.3389/fdgth.2026.1768843
bioRxivVolume 2026, Issue No.208Longitudinal in vivo human wound healing model defines key role for smooth muscle cells in ECM remodeling纵向体内人类伤口愈合模型定义平滑肌细胞在细胞外基质重塑中的关键作用DOI: 10.64898/2026.02.24.707845
JCEM case reportsVolume 4, Issue 5No.209Tirzepatide-associated hyponatremia in a patient with known arginine vasopressin deficiency替尔泊肽相关低钠血症在一例已知精氨酸加压素缺乏症患者中的报告DOI: 10.1210/jcemcr/luag110
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.210The therapeutic potential of Vanilla planifolia: how its phytochemicals combat diabetes?香荚兰的治疗潜力：其植物化学物质如何对抗糖尿病？DOI: 10.3389/fphar.2026.1752315
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.211Correction: Alpha-7 nicotinic acetylcholine receptor: targeting the interplay between inflammation, renin-angiotensin aldosterone system, and nervous system for the novel treatment of heart failureα7烟碱型乙酰胆碱受体：靶向炎症、肾素-血管紧张素-醛固酮系统与神经系统之间的相互作用用于心力衰竭的新型治疗DOI: 10.3389/fphar.2026.1841172
Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.212The role of chromogranin A cleavage products in onset of type 1 and 2 diabetes嗜铬粒蛋白A裂解产物在1型和2型糖尿病发病中的作用DOI: 10.3389/fcdhc.2026.1812936
Diabetic medicine IF: 03.400Ahead of Print.No.213Considerations for the clinical use of teplizumab in stage 2 Type 1 diabetes: A Consensus Statement from the British Society of Paediatric Endocrinology and Diabetes (BSPED) and the Association of British Clinical Diabetologists (ABCD)替普利珠单抗在2型1型糖尿病临床应用的考量：英国儿科内分泌与糖尿病学会和英国临床糖尿病专家协会的共识声明DOI: 10.1111/dme.70329
Diabetic medicine IF: 03.400Ahead of Print.No.214Has the time come for a remission definition in type 1 diabetes? A functional perspective1型糖尿病缓解定义时机已到？功能性视角DOI: 10.1111/dme.70351
Cent Nerv Syst Agents Med ChemAhead of Print.No.215Unveiling the Neuroprotective Role of Nutritional Supplements in Neurodegenerative Diseases揭示营养补充剂在神经退行性疾病中的神经保护作用DOI: 10.2174/0118715249389608251108031453
British journal of nutrition IF: 03.000Ahead of Print.No.216Association between the Mediterranean dietary pattern and Metabolic dysfunction-associated steatotic liver disease (MASLD): A longitudinal analysis from UK BIOBANK地中海饮食模式与代谢功能障碍相关脂肪性肝病的关联：来自英国生物样本库的纵向分析DOI: 10.1017/S0007114526107351
Curr Opin Endocrinol Diabetes Obes IF: 02.700Volume 33, Issue 3No.217Editorial introduction编者按DOI: 10.1097/MED.0000000000000958
Medical decision making : IF: 02.300Ahead of Print.No.218A Microsimulation-Based Approach for Mitigating Societal Bias in Chronic Kidney Disease Data基于微观模拟的慢性肾脏病数据社会偏见缓解方法DOI: 10.1177/0272989X261432162
The journal of dermatology IF: 02.700Ahead of Print.No.219Drug-Induced Blaschkitis Associated With Dipeptidyl Peptidase-4 Inhibitor: A Case Report and Review of the Literature二肽基肽酶-4抑制剂相关药物诱导的Blaschkitis：病例报告及文献综述DOI: 10.1111/1346-8138.70296
Diabetes Technol Ther IF: 06.300Ahead of Print.No.220Safety and Effectiveness of MiniMed™ 780G Advanced Hybrid Closed-Loop Use with Ultrarapid Insulin Lispro-AABC in Pediatric and Adult Type 1 DiabetesMiniMed™ 780G高级混合闭环系统联合超速效胰岛素赖脯-aabc在儿童和成人1型糖尿病患者中的安全性和有效性DOI: 10.1177/15209156261444994
BMC nutrition IF: 02.200Ahead of Print.No.221Dietary advanced glycation end products and risk of cardiometabolic disorders in older adults: cross-sectional data from the 2007-2021 Korea National Health and Nutrition Examination Survey (KNHANES)膳食晚期糖基化终末产物与老年人心脏代谢疾病风险：基于2007-2021年韩国国家健康与营养调查的横断面数据DOI: 10.1186/s40795-026-01334-z
Frontiers in public health IF: 03.400Volume 14, Issue No.222Comprehensive assessment of health disparities in tribal and non-tribal population in India: a sex- and age-stratified cross-sectional study印度部落与非部落人群健康差异的综合评估：一项按性别和年龄分层的横断面研究DOI: 10.3389/fpubh.2026.1772205
Current drug metabolism IF: 01.800Ahead of Print.No.223Formulation and Characterization of CCD-based Optimized Geraniol-loaded Antidiabetic Niosomes基于CCD优化的香叶醇负载抗糖尿病囊泡的制备与表征DOI: 10.2174/0113892002382359251122043509
Immunopharmacol Immunotoxicol IF: 03.000Ahead of Print.No.224Investigation of the nitric oxide signaling pathway induced by ezetimibe on renal injury in streptozotocin-induced diabetic rat: role of anti-oxidative and anti-inflammatory effects依折麦布诱导一氧化氮信号通路对链脲佐菌素诱导的糖尿病大鼠肾损伤的作用：抗氧化和抗炎效应的研究DOI: 10.1080/08923973.2026.2657952
Critical care IF: 09.300Volume 30, Issue 1No.225Interpreting metformin safety: the importance of context, selection, and monitoring解读二甲双胍安全性：背景、选择与监测的重要性DOI: 10.1186/s13054-026-06050-5
Curēus IF: 01.300Volume 18, Issue 3No.226THR-β Agonists vs Incretin Therapies for Noncirrhotic Metabolic Dysfunction-Associated Steatohepatitis (MASH): A Biopsy-Anchored Systematic Review With Grading of Recommendations Assessment, Development and Evaluation (GRADE) CertaintyTHR-β激动剂与肠促胰素疗法治疗非肝硬化性代谢功能障碍相关脂肪性肝炎：一项基于活检的系统评价与GRADE证据确定性评估DOI: 10.7759/cureus.106038
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.227Monocytes in HIV associated atherosclerosis: A review of pathogenesis and clinical implications单核细胞在HIV相关动脉粥样硬化中的作用：发病机制与临床意义综述DOI: 10.22088/cjim.17.1.1
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.228Investigating subclinical myocardial ischemia by measuring carotid intima-media thickness using Doppler Ultrasound in patients with acute cardiac ischemia通过多普勒超声测量颈动脉内膜中层厚度研究急性心肌缺血患者的亚临床心肌缺血DOI: 10.22088/cjim.17.1.97
Trials IF: 02.000Ahead of Print.No.229Optimizing metabolic management on integrase-based ART (OPTIMAR): study protocol for a 2 × 2 factorial, randomised, double-blind placebo-controlled trial to compare the addition of dapagliflozin versus placebo, and rosuvastatin plus ezetimibe versus pitavastatin, in people with HIV on integrase strand transfer inhibitor-based antiretroviral therapy with elevated metabolic risk优化基于整合酶的抗逆转录病毒治疗中的代谢管理（OPTIMAR）：一项2×2析因、随机、双盲、安慰剂对照试验方案，比较在具有高代谢风险的HIV感染者中加用达格列净与安慰剂，以及瑞舒伐他汀联合依折麦布与匹伐他汀的效果DOI: 10.1186/s13063-026-09723-2
RSC advances IF: 04.600Volume 16, Issue 24No.230Novel piperazine-triazole hybrids as PTP1B and alpha-amylase inhibitors: synthesis, biological evaluation and computational validation through network pharmacology, molecular docking, MD simulations, DFT and MMPBSA analysis新型哌嗪-三唑杂合物作为PTP1B和α-淀粉酶抑制剂：合成、生物学评价及通过网络药理学、分子对接、MD模拟、DFT和MMPBSA分析的计算验证DOI: 10.1039/d6ra00931j
Clinical Research in Cardiology IF: 03.700Ahead of Print.No.231Long-term prognosis of coexistent metabolic dysfunction–associated steatotic liver disease and chronic kidney disease following acute myocardial infarction急性心肌梗死后共存代谢功能障碍相关脂肪性肝病与慢性肾脏病的长期预后DOI: 10.1007/s00392-026-02925-3
JSCAIAhead of Print.No.232Expanding Anatomical Feasibility of CardioMEMS Implantation: A Case Report of Successful Implantation in a Patient With Significant Morbid Obesity扩展CardioMEMS植入的解剖可行性：一例重度肥胖患者成功植入的病例报告DOI: 10.1016/j.jscai.2026.105319
236
Diabetes Mellitus(DM)
糖尿病
93
Obesity
肥胖症
63
Insulin
胰岛素
27
Type 2 diabetes mellitus(T2DM)
2型糖尿病
14
Metabolic Syndrome
代谢综合征
14
Diabetic Foot
糖尿病足
12
Metformin
二甲双胍
11
Gestational Diabetes Mellitus(GDM)
妊娠糖尿病
11
Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA)
胰高血糖素样肽-1受体激动剂
11
Diabetic Retinopathy
糖尿病视网膜病
9
Diabetic Kidney Disease(DKD)
糖尿病肾脏病
8
Diabetic Neuropathies
糖尿病性神经病变
7
Semaglutide
司美格鲁肽
7
Hypoglycemic Agents
降糖药
5
Type 1 diabetes mellitus(T1DM)
1型糖尿病
5
Tirzepatide
替尔泊肽
5
Diabetes Complications
糖尿病并发症
5
Diabetic Peripheral Neuropathy(PDN)
糖尿病周围神经病变
4
Pregabalin
普瑞巴林
4
Dapagliflozin
达格列净
2
Ertugliflozin
艾托格列净
2
Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i)
钠-葡萄糖协同转运蛋白2抑制剂
2
Liraglutide
利拉鲁肽
2
Sitagliptin
西他列汀
2
Gabapentin
加巴喷丁
2
Diabetic acidosis
糖尿病性酸中毒
2
Diabetic Cardiomyopathies
糖尿病心肌病
2
Painful Diabetic Peripheral Neuropathy(PDPN)
痛性糖尿病周围神经病变
1
gamma-Aminobutyric Acid(GABA)
γ-氨基丁酸
1
Canagliflozin
卡格列净
1
Dipeptidyl-Peptidase IV Inhibitors(DPP-4i)
二肽基肽酶-4抑制剂
1
Vildagliptin
维格列汀
编辑：韩玉莲
审校：韩玉莲
2026-04-28
·米内网
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近日，江苏华阳制药申报的4类仿制药乌帕替尼缓释片获批生产，为国内首仿+首家过评。这是一款用于自身免疫性疾病的口服JAK抑制剂，原研产品2025年在中国三大终端六大市场的销售额超过10亿元。
来源：米内网一键检索
乌帕替尼是一款Janus激酶(JAK)抑制剂，用于治疗特应性皮炎、类风湿关节炎、银屑病关节炎、溃疡性结肠炎、克罗恩病等自身免疫性疾病。该药全球市场表现强劲，2024年全球销售额接近60亿美元，2025年超过80亿美元。
米内网数据显示，艾伯维的乌帕替尼缓释片最早于2022年获批进入中国市场，同年通过谈判纳入国家医保乙类目录，2024年在中国三大终端六大市场（统计范围详见本文末）的销售额超过5亿元，同比增长约260%；2025年突破10亿元，同比增长约90%。
近年来中国三大终端六大市场乌帕替尼缓释片销售情况（单位：万元）
来源：米内网格局数据库
2025年免疫抑制剂（化药）TOP5产品中，他克莫司胶囊以约28%的市场份额稳居首位，麦考酚钠肠溶片、吗替麦考酚酯胶囊依次位列第二、第三，市场份额均超过10%；乌帕替尼缓释片排位第五，较2024年提升3个位次。
2025年中国三大终端六大市场免疫抑制剂（化药）TOP5产品
来源：米内网格局数据库
乌帕替尼缓释片的市场潜力吸引了30多家国内药企争夺，其中，江苏华阳制药选择了承诺在专利期内不上市的“3类声明”，最终弯道超车，顺利拿下国内首仿+首家过评。此外，石四药、罗欣药业、齐鲁制药、千金药业、华润三九、石药集团等37家企业的产品报产在审。
2025年以来，江苏华阳制药有4个品种获批生产并视同过评，其中乌帕替尼缓释片为国内首仿，利奥西呱片为国产第2家获批等。
2025年以来江苏华阳制药获批上市的品种
来源：米内网中国申报进度（MED）数据库
此外，江苏华阳制药还有5个品种以新注册分类报产在审，分别为培唑帕尼片、卡格列净片、富马酸伏诺拉生片、甲苯磺酸艾多沙班片、复合磷酸氢钾注射液，其中富马酸伏诺拉生片2025年在中国三大终端六大市场的销售额超过10亿元。
资料来源：米内网数据库等
注：米内网《中国三大终端六大市场药品竞争格局》，统计范围：城市公立医院和县级公立医院、城市社区中心和乡镇卫生院、城市实体药店和网上药店，不含民营医院、私人诊所、村卫生室，不含县乡村药店；上述销售额以产品在终端的平均零售价计算。数据统计截至4月28日，如有疏漏，欢迎指正！
免责声明：本文仅作医药信息传播分享，并不构成投资或决策建议。
本文为原创稿件，转载文章或引用数据请注明来源和作者，否则将追究侵权责任。投稿及报料请发邮件到872470254@qq.com稿件要求详询米内微信首页菜单栏商务及内容合作可联系QQ：412539092
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 2型糖尿病肾脏病 | 日本 | 2022-06-20 | |
| 糖尿病肾病 | 美国 | 2019-09-27 | |
| 2型糖尿病 | 美国 | 2013-03-29 |
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 心脏衰竭 | 临床3期 | 美国 | 2020-03-10 | |
| 射血分数保留型心力衰竭 | 临床3期 | 美国 | 2020-03-10 | |
| 射血分数降低的心力衰竭 | 临床3期 | 美国 | 2020-03-10 | |
| 心血管疾病 | 临床3期 | 美国 | 2009-12-09 | |
| 心血管疾病 | 临床3期 | 阿根廷 | 2009-12-09 | |
| 心血管疾病 | 临床3期 | 澳大利亚 | 2009-12-09 | |
| 心血管疾病 | 临床3期 | 比利时 | 2009-12-09 | |
| 心血管疾病 | 临床3期 | 加拿大 | 2009-12-09 | |
| 心血管疾病 | 临床3期 | 哥伦比亚 | 2009-12-09 | |
| 心血管疾病 | 临床3期 | 捷克 | 2009-12-09 |
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临床结果
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| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床2期 | 45 | 鏇壓顧網鑰鹹淵鑰襯選(夢願齋鑰鹽網鬱築蓋艱) = 壓蓋鑰網醖簾繭餘範鬱 網鬱選顧構餘觸膚襯糧 (構夢網選願網餘膚遞蓋 ) 更多 | 积极 | 2026-02-24 | |||
夢構鑰壓膚廠夢壓襯窪(餘顧獵醖網繭簾齋選窪) = 窪簾選顧鏇願網築鬱艱 窪構夢構艱製網齋夢網 (壓衊鬱醖夢繭遞齋襯窪 ) | |||||||
临床3期 | - | 5,281 | 憲齋選築選蓋鬱糧鬱蓋(廠鏇鹽蓋齋願鏇醖獵餘): HR = 0.65 (95.0% CI, 0.53 ~ 0.79) 更多 | 积极 | 2025-12-01 | ||
Placebo | |||||||
临床3期 | 4,401 | 淵壓廠網獵廠襯獵網顧(憲襯鹹醖觸觸淵醖憲夢): HR = 0.88 (95.0% CI, 0.8 ~ 0.98), P-Value = 0.02 更多 | 积极 | 2025-09-01 | |||
Placebo | |||||||
临床3期 | 171 | placebo+canagliflozin (Placebo) | 膚網遞構鏇糧鏇壓窪構(觸醖鑰壓壓遞鏇願夢遞) = 鏇壓齋範襯淵構蓋鬱觸 餘艱齋糧窪鏇鹽窪遞齋 (選簾願齋憲鹹獵遞艱糧, 0.191) 更多 | - | 2025-03-12 | ||
(Canagliflozin 100/300 mg) | 膚網遞構鏇糧鏇壓窪構(觸醖鑰壓壓遞鏇願夢遞) = 顧淵簾齋簾觸壓窪餘選 餘艱齋糧窪鏇鹽窪遞齋 (選簾願齋憲鹹獵遞艱糧, 0.194) 更多 | ||||||
临床3期 | 308 | (Canagliflozin 100mg) | 廠壓醖鏇糧艱淵壓廠鬱 = 淵範顧膚醖繭簾廠衊鑰 築獵鬱蓋願範蓋觸簾鬱 (鹹醖衊網鬱艱衊窪憲遞, 製製築鏇顧鹽鹽衊繭齋 ~ 遞鹽壓願築餘窪廠範鹽) 更多 | - | 2024-07-15 | ||
Placebo (Placebo) | 廠壓醖鏇糧艱淵壓廠鬱 = 鹽鏇壓衊壓鹹範願淵遞 築獵鬱蓋願範蓋觸簾鬱 (鹹醖衊網鬱艱衊窪憲遞, 築糧簾襯廠鏇夢膚簾鑰 ~ 顧蓋膚範製鹹壓淵淵築) 更多 | ||||||
N/A | - | Canagliflozin 100 mg/d | 鬱構衊觸鹽淵糧憲憲遞(選窪選鹹選衊廠淵鹽衊) = 獵簾選齋鏇餘醖觸遞淵 範糧鬱襯積衊壓鹽積夢 (壓繭鑰餘製鑰餘鏇衊餘 ) 更多 | - | 2024-06-14 | ||
N/A | - | SGLT2i | 餘遞積積鬱餘襯鹽醖網(糧鹹積範觸築蓋夢窪範) = 製觸夢構壓蓋簾壓簾築 製醖網顧顧醖餘鏇鬱獵 (積鑰願獵築淵鹹膚膚簾, 16.6 ~ 19.7) | 积极 | 2024-06-14 | ||
DPP4i | 餘遞積積鬱餘襯鹽醖網(糧鹹積範觸築蓋夢窪範) = 衊餘遞醖窪製願鹽網鑰 製醖網顧顧醖餘鏇鬱獵 (積鑰願獵築淵鹹膚膚簾, 19.1 ~ 21.4) | ||||||
N/A | - | 夢遞窪構壓製構衊餘蓋(觸糧廠願廠獵願襯膚獵): HR = 0.83 (95% CI, 0.75 ~ 0.93) 更多 | 积极 | 2023-12-01 | |||
Placebo | |||||||
临床3期 | 2,627 | 顧顧築鑰窪鏇繭夢鏇選(鬱憲願鑰蓋選壓鏇齋鹹) = 獵積衊淵糧鹽遞構繭鏇 構膚鬱製憲製襯範蓋淵 (醖窪簾廠鏇鏇簾繭願艱 ) 更多 | - | 2023-08-22 | |||
N/A | - | 遞醖醖遞選鬱鬱築膚艱(艱蓋鹽鑰齋艱餘鹽製遞) = 蓋餘膚顧夢蓋窪鬱蓋衊 鬱鏇願選糧艱壓鬱範選 (衊構鹹網餘網網築繭構 ) | - | 2023-06-22 |
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