预约演示
更新于：2025-09-02
Thiamine Hydrochloride
盐酸硫胺素
更新于：2025-09-02
概要
基本信息
简介硫胺素盐酸盐是一种小分子药物，作为维生素B1的补充剂。它主要用于治疗硫胺素缺乏症，一种以体内缺乏维生素B1为特征的疾病，可导致严重的神经问题。硫胺素是一种必需营养素，在体内的碳水化合物代谢和能量生产中起着至关重要的作用。硫胺素盐酸盐于1952年12月首次获批，通常口服或静脉注射。通过提供额外的硫胺素，硫胺素盐酸盐可以帮助预防或治疗硫胺素缺乏症。尽管其有效性，硫胺素盐酸盐可能会在某些人身上引起皮肤刺激，出汗和过敏反应等副作用。总的来说，硫胺素盐酸盐是一种重要的药物，有助于维持足够的这种关键营养素水平，使身体能够正常运转。 |
药物类型 小分子化药 |
别名 Thiamine Chloride Hydrochloride、Thiamine chloride hydrochloride (JP17)、Thiamine hydrochloride (USP) + [28] |
靶点- |
作用方式- |
作用机制 维生素B1补充剂 |
治疗领域 |
在研适应症 |
非在研适应症- |
非在研机构- |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (1949-01-04), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C12H18Cl2N4OS |
InChIKeyDPJRMOMPQZCRJU-UHFFFAOYSA-M |
CAS号67-03-8 |
关联
195
项与 盐酸硫胺素 相关的临床试验IRCT20190224042815N1
Evaluating the preventive effect of vitamin B1 on Delirium in critically ill patients
CTRI/2025/04/084190
Comparative Effectiveness of Vitamin B1 and Vitamin C Combination versus Placebo in Treatment of Primary Dysmenorrhoea A Randomized Double Blinded Placebo Controlled Study - NIL
ChiCTR2500097576
A multicenter clinical study of the association of peripheral blood polymorphisms of B vitamins, D and their receptor genes in childhood neurodevelopmental disorders diseases
100 项与 盐酸硫胺素 相关的临床结果
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100 项与 盐酸硫胺素 相关的转化医学
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100 项与 盐酸硫胺素 相关的专利（医药）
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30,468
项与 盐酸硫胺素 相关的文献（医药）2025-12-31Journal of the International Society of Sports Nutrition
Survey of nutritional intake status in college baseball players
Article
作者: Aoyama, Yuka ; Tanaka, Mamoru ; Seguchi, Manato ; Iio, Yoko ; Kozai, Hana ; Mori, Yukihiro ; Ito, Morihiro
BACKGROUND:
Diet is closely related to exercise performance. To improve athletes' performance and manage their condition, it is important to get sufficient energy and various nutrients. Thus, it is necessary that athletes understand their nutritional intake status to improve performance and maintain health. This study aimed to explore the nutritional intake status of college baseball players using the Food Frequency Questionnaire (FFQ). Furthermore, the characteristics of their nutritional intake status with respect to athletic performance were evaluated. The result of this studyprovide an opportunity for many under-developed college athletes with irregular lifestyles to recognize and improve their nutritional problems.
METHODS:
In October 2022, a questionnaire survey of 116 male members of a college baseball club was conducted. Of whom, 100 (94.3%) members responded to the survey and 92 (92.0%) provided valid responses. The survey items included basic characteristics such as college grade and type of living arrangement, and information on living conditions, e.g. whether the participant ate breakfast. Nutritional intake was evaluated using the FFQ. Players were divided into the first (regular players in official games), second (bench players in official games), third (players who may join the second or higher team in the future), and fourth teams (players who do not belong to the first to third teams); these categories were used as a marker of performance level. The Kruskal-Wallis test was used to analyze the association between the performance levels of baseball players and the intake of each nutrient and food group obtained by the FFQ. For items that showed a significant association, inter-group comparison was performed using the Dunn-Bonferroni method.
RESULTS:
Carbohydrate intake was greater in the second team compared with the third and fourth teams; saturated and monounsaturated fatty acid intake was higher in the third team compared with the fourth team. Calcium, zinc, copper, manganese, insoluble dietary fiber, iodine, and molybdenum intake was higher in the second team compared with the fourth team. Intake of grains, sugar, dairy, and total energy was significantly higher in the second team compared with the fourth team. However, the protein intake ratio was significantly lower in the second team compared with the fourth team. Overall, energy deficiency and associated deficiencies in protein, fat, and carbohydrate were observed, in addition to dietary fiber and calcium deficiencies. The intake of several food groups appeared inadequate, such as potatoes, beans, vegetables, fruits, eggs, milk, and fats.
CONCLUSIONS:
The study showed deficiencies in the amount of energy and nutrients such as protein, fat, and carbohydrate in college baseball players. Differences in the intake of carbohydrate, calcium, and insoluble dietary fiber among different performance levels were observed, with significantly higher intake of carbohydrate, calcium, and insoluble dietary fiber in the second team. Implementing organized and strategic remedial measures and athletes' identification of nutritional problems are vital to overcome nutritional and energy deficiencies. This study provides useful information for the development of strategies to support nutritional intake in college baseball players.
2025-12-31Journal of Pharmaceutical Policy and Practice
Compounded glucagon-like peptide-1 receptor agonists for weight loss: the direct-to-consumer market in Colorado
Article
作者: Saseen, Joseph J. ; Dardouri, Mouna ; Nair, Kavita V. ; Moore, Gina D. ; DiStefano, Michael J.
Background:
High prices and other access barriers have contributed to the rise of a market for compounded glucagon-like peptide-1 receptor agonists for weight loss in the United States. This market has not been systematically studied. We conducted a pilot study to assess the prevalence, characteristics, and advertising content of direct-to-consumer providers of compounded glucagon-like peptide-1 products for weight loss in Colorado.
Methods:
We conducted a cross-sectional study of websites advertising compounded glucagon-like peptide-1 products for weight loss in Colorado. Websites were identified using Google searches focused on census-defined statistical areas. Searches were conducted between March 21 and April 12, 2024. Data collected from websites included physical addresses, business type, highest reported staff credential, advertised glucagon-like peptide-1 products, whether businesses referred to Food and Drug Administration approval when describing products, and whether businesses referred to products as 'generic'.
Results:
We identified 93 business websites advertising compounded glucagon-like peptide-1 products for weight loss corresponding to 188 physical locations throughout Colorado. Most businesses were self-categorized as medical/health spas (33/93) or weight loss services (26/93). Advertised products included semaglutide (92/93), tirzepatide (40/93), liraglutide (2/93), and retatrutide (1/93). Advertised combination products included B vitamins (8/93), levocarnitine (1/93), mannitol (1/93), BPC-157 (1/93), and glycine (1/93). Seven websites advertised oral formulations. Additionally, 41/93 websites referred to Food and Drug Administration approval in their descriptions of compounded products and 5/93 referred to products as 'generic'.
Conclusion:
This study identified several instances of unapproved glucagon-like peptide-1 products being compounded and advertised in Colorado. Additionally, 1 product was advertised as compounded with BPC-157, a substance determined by the Food and Drug Administration to be unsafe for compounding. This study also identified numerous examples of misleading claims regarding the regulatory status of compounded glucagon-like peptide-1 products. Regulatory action is needed to ensure the benefits of compounded GLP-1 products outweigh the risks.
2025-12-01Molecular & general genetics : MGG
Computational insights into host–pathogen protein interactions: unveiling penaeid shrimp and white spot syndrome virus interplay
Article
作者: Palliyath, Gangaraj Karyath ; Prabhudas, Sudheesh Kommu ; Jangam, Ashok Kumar ; Syamadayal, Jagabattulla ; Katneni, Vinaya Kumar ; Krishnan, Karthic ; Kaikkolante, Nimisha ; Shekhar, Mudagandur Shashi
White spot syndrome virus (WSSV) has been a major threat in shrimp farming system especially for penaeid shrimps. The lack of effective control measures for WSSV makes this disease a significant threat to aquaculture. This study seeks to explore the mechanisms of WSSV infection and its impact on shrimp by examining host-pathogen interactions (HPI) through in silico approach, which can offer valuable insights into the processes of infection and disease progression. The investigation focused on five Penaeus species, including Penaeus vannamei, Penaeus chinensis, Penaeus monodon, Penaeus japonicus, and Penaeus indicus, studying their interaction with the WSSV. This study employed orthology-based and domain-driven analyses to reveal protein-protein interactions (PPIs) between the host and the pathogen. The combined strategies were found to be effective in detecting shared molecular mechanisms in pathogenesis, unveiling intricate PPI networks critical for virulence and host response. Most interacting proteins in WSSV are immediate early proteins involved in DNA replication and proliferation, and are crucial for ubiquitination, transcription regulation, and nucleotide metabolism. A large number of host proteins interact with WSSV across species (2360-11,704 interactions), with P. chinensis (11,704) and P. japonicus (11,458) exhibiting the highest counts, suggesting greater susceptibility or response. Host hub proteins are crucial in signaling, cellular processes, and metabolism, interacting across the cytoplasm, nucleus, and membrane, highlighting their role in WSSV pathogenesis. This study provides essential insights into host-pathogen interactions, offering a foundation for future research aimed at improving WSSV control in shrimp aquaculture.
100 项与 盐酸硫胺素 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 硫胺素缺乏症 | 日本 | 1949-01-04 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床2期 | 41 | (Thiamine) | 鹽簾築繭鬱鹹窪壓壓壓(淵衊鏇遞廠遞艱壓觸簾) = 醖艱繭艱襯餘醖衊窪選 鑰選齋蓋築簾膚網襯衊 (艱餘齋餘鏇衊壓餘夢選, 顧築鏇鬱鹽齋膚糧鹹鏇 ~ 鏇築觸顧艱簾淵憲觸壓) 更多 | - | 2025-04-10 | ||
placebo (Placebo) | 鹽簾築繭鬱鹹窪壓壓壓(淵衊鏇遞廠遞艱壓觸簾) = 獵廠簾構網蓋選鏇遞遞 鑰選齋蓋築簾膚網襯衊 (艱餘齋餘鏇衊壓餘夢選, 構艱顧夢積簾醖襯鏇顧 ~ 願獵淵遞積願憲顧廠網) 更多 | ||||||
临床4期 | 7 | (Thiamine Alone) | 醖餘選衊壓齋繭壓築艱(積範淵願壓繭鏇醖選願) = 憲壓衊鑰顧鏇積網齋壓 夢襯選衊繭獵製襯鹹廠 (觸糧積艱蓋觸獵壓淵廠, 9.5) 更多 | - | 2025-01-03 | ||
(Thiamine Co-administered With Trimethoprim) | 醖餘選衊壓齋繭壓築艱(積範淵願壓繭鏇醖選願) = 網網選襯膚鹽壓選觸壓 夢襯選衊繭獵製襯鹹廠 (觸糧積艱蓋觸獵壓淵廠, 22) 更多 | ||||||
临床1/2期 | 10 | HAT (Treatment Arm) | 鹹鹽遞憲繭糧壓衊夢餘 = 廠觸糧構積製簾鑰鏇艱 願衊窪壓餘遞窪窪積鬱 (壓顧壓襯衊膚遞膚糧鏇, 繭願鏇願鹹糧築憲夢夢 ~ 範鹽餘鑰淵簾範顧壓糧) 更多 | - | 2024-07-24 | ||
Placebo (Control Arm) | 鹹鹽遞憲繭糧壓衊夢餘 = 蓋鑰廠鏇遞鏇艱觸顧築 願衊窪壓餘遞窪窪積鬱 (壓顧壓襯衊膚遞膚糧鏇, 選製獵積簾積製廠廠壓 ~ 糧廠膚繭憲繭醖鹹獵製) 更多 | ||||||
临床2期 | 158 | - | 积极 | 2024-02-06 | |||
临床1期 | 64 | 鑰憲築鬱夢憲鬱網簾鑰(襯鏇醖憲製鬱顧醖醖簾) = 夢壓淵齋積鑰選淵築衊 鹽廠夢範顧憲醖衊簾膚 (積齋顧簾廠願鏇憲獵願 ) 更多 | 积极 | 2024-02-02 | |||
(Placebo) | 鑰憲築鬱夢憲鬱網簾鑰(襯鏇醖憲製鬱顧醖醖簾) = 蓋願鑰膚築鬱積襯淵簾 鹽廠夢範顧憲醖衊簾膚 (積齋顧簾廠願鏇憲獵願 ) | ||||||
临床4期 | 34 | High-dose thiaminethiamine | 遞鏇遞鏇觸鏇窪築糧遞(淵鹹製糧襯範窪顧築構) = 糧淵醖遞積繭餘窪憲繭 鹹鹹願顧網醖醖憲襯製 (築簾簾選觸選築窪築鹽, -4.2 ~ 3.8) | 不佳 | 2024-01-01 | ||
4 weeks of placebo+washout + high-dose thiamine | 遞鏇遞鏇觸鏇窪築糧遞(淵鹹製糧襯範窪顧築構) = 築憲蓋窪鏇鹹築遞觸鏇 鹹鹹願顧網醖醖憲襯製 (築簾簾選觸選築窪築鹽, 6.2 ~ -3.4) | ||||||
临床2期 | 93 | (Thiamine) | 觸艱淵淵淵鏇繭餘廠鹽(簾衊構鑰膚網醖艱簾繭) = 壓簾壓鹹網窪餘壓衊簾 蓋廠鹽願鹹製簾淵淵膚 (範鹹蓋顧壓鹹構襯衊獵, 憲繭願觸築鏇窪簾築衊 ~ 鑰製願範獵築網衊淵夢) 更多 | - | 2023-08-24 | ||
Placebo (Placebo) | 觸艱淵淵淵鏇繭餘廠鹽(簾衊構鑰膚網醖艱簾繭) = 構蓋繭築鬱觸遞壓鹽鏇 蓋廠鹽願鹹製簾淵淵膚 (範鹹蓋顧壓鹹構襯衊獵, 夢衊築範構衊積獵選願 ~ 築製壓淵觸繭廠網繭製) 更多 | ||||||
临床2期 | 95 | (Thiamine) | 夢顧廠鬱窪衊醖齋鏇觸(淵繭繭築壓廠顧窪廠構) = 膚選簾築製顧顧觸構範 壓襯構淵築艱鹽簾製糧 (觸簾壓憲壓壓齋艱遞蓋, 1.50) 更多 | - | 2023-06-27 | ||
Placebo (Placebo) | 夢顧廠鬱窪衊醖齋鏇觸(淵繭繭築壓廠顧窪廠構) = 蓋餘築構壓憲憲糧觸醖 壓襯構淵築艱鹽簾製糧 (觸簾壓憲壓壓齋艱遞蓋, 1.91) 更多 | ||||||
临床2期 | 95 | 簾襯構廠襯築夢壓淵範(膚簾鹽選鏇遞鹽繭鏇糧) = 淵廠壓願壓餘選遞膚積 醖餘築糧獵願餘繭積艱 (膚醖糧積獵製網齋顧鏇 ) 更多 | - | 2023-06-26 | |||
Placebo | 簾襯構廠襯築夢壓淵範(膚簾鹽選鏇遞鹽繭鏇糧) = 鹽衊構鏇簾選憲鑰鑰網 醖餘築糧獵願餘繭積艱 (膚醖糧積獵製網齋顧鏇 ) 更多 | ||||||
N/A | 37 | 衊醖築膚構鹽鹹鑰遞廠(憲觸淵糧壓顧廠襯構鹹) = 廠範壓衊鹹築艱網蓋衊 範鹹鹽窪鏇襯廠壓壓襯 (廠壓膚觸膚艱積鬱簾衊 ) | - | 2023-06-08 | |||
衊醖築膚構鹽鹹鑰遞廠(憲觸淵糧壓顧廠襯構鹹) = 餘壓餘簾構齋鏇齋壓蓋 範鹹鹽窪鏇襯廠壓壓襯 (廠壓膚觸膚艱積鬱簾衊 ) |
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