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更新于：2025-01-26
Trimethoprim
甲氧苄啶
更新于：2025-01-26
概要
基本信息
药物类型 小分子化药 |
别名 TMP、Trimethoprim (JAN/USP/INN)、BW-56-72 + [7] |
作用机制 Bacterial DHFR抑制剂(细菌二氢叶酸还原酶抑制剂) |
非在研适应症- |
最高研发阶段批准上市 |
首次获批日期 美国 (1980-05-30), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C14H18N4O3 |
InChIKeyIEDVJHCEMCRBQM-UHFFFAOYSA-N |
CAS号738-70-5 |
关联
30
项与 甲氧苄啶 相关的临床试验NCT06536374
A Phase II, Open Label, Randomized Controlled Pilot Study Evaluating Trimethoprim in Patients Commencing Androgen Deprivation Therapy for Prostate Cancer
NCT06709196
REINFORCE - Reducing Infection-related Readmissions Following Cystectomy. a Multicentre Randomised Clinical Trial Testing Superiority of Individualised Targeted Antibiotic Prophylaxis Over Empiric Prophylaxis At Ureteral Stent Removal to Reduce Infection-related Readmissions Following Cystectomy.
ChiCTR2200066181
A study on the effect of trimethoprim plus thioglycollate gel filling for the prevention of postoperative stricture in large esophageal ESD
100 项与 甲氧苄啶 相关的临床结果
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100 项与 甲氧苄啶 相关的转化医学
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100 项与 甲氧苄啶 相关的专利（医药）
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28,288
项与 甲氧苄啶 相关的文献（医药）2025-03-01JOURNAL OF HAZARDOUS MATERIALS
Profiling trace organic chemical biotransformation genes, enzymes and associated bacteria in microbial model communities
Article
作者: Wurzbacher, Christian ; Cao, Lijia ; Garcia, Sarahi L
Microbial biotransformation of trace organic chemicals (TOrCs) is an essential process in wastewater treatment to eliminate environmental pollution. Understanding TOrC biotransformation mechanisms, especially at their original concentrations, is important to optimize treatment performance, whereas our current knowledge is limited. Here, we investigated the biotransformation of seven TOrCs by 24 model communities. The genome-centric analyses unraveled potential biotransformation drivers concerning functional genes, enzymes, and responsible bacteria. We obtained efficient model communities for completely removing ibuprofen, caffeine, and atenolol, with transformation efficiencies between 0 % and 45 % for sulfamethoxazole, carbamazepine, trimethoprim, and gabapentin. Biotransformation performance was not fully reflected by the presence of known biotransformation genes and enzymes in the metagenomes of the communities. Functional similar homologs to existing biotransformation genes and enzymes (e.g., long-chain-fatty-acid-CoA ligase encoded by fadD and fadD13 gene) could play critical roles in TOrC metabolism. Finally, we identified previously undescribed degrading strains, e.g., Rhodococcus qingshengii for caffeine, carbamazepine, sulfamethoxazole, and ibuprofen biotransformation, and potential transformation enzymes, e.g., SDR family oxidoreductase targeting sulfamethoxazole and putative hypothetical proteins for caffeine, atenolol and gabapentin biotransformation. This study provides fundamental insights into naturally assembled low-complexity degrader communities that can help to identify and tackle the current research gaps on biotransformation.
2025-03-01ENVIRONMENTAL RESEARCH
Pilot-scale adsorption of pharmaceuticals from municipal wastewater effluent using low-cost magnetite-pine bark: Regeneration/enumeration of viable bacteria with a study on their biotoxicity
Article
作者: Risteelä, Sofia ; Mohammadzadeh, Mahdiyeh ; Brandt, Kristian Koefoed ; Lassen, Simon Bo ; Bello, Adedayo ; Leiviskä, Tiina
A low-cost and renewable magnetite-pine bark (MPB) sorbent was evaluated in continuous-flow systems for the removal of various pharmaceuticals from municipal wastewater effluent following membrane bioreactor (MBR) treatment. A 33-day small-scale column test (bed volume: 791 cm3) was conducted using duplicate columns of biochar (BC, Novocarbo) and activated carbon (AC, ColorSorb) as reference for two columns of BC and MPB in order to compare the efficiency of AC and MPB. After the small-scale column test, the pharmaceutical concentrations were generally below the detection limit. In the next stage, a four-month pilot-scale adsorption test was performed using a large column (bed volume: 21 L) filled with BC and MPB. A variety of compounds were removed after the pilot-scale column, including trimethoprim (99.7%), hydrochlorothiazide (81.8%), candesartan (26.0%), carbamazepine (86.1%), ketoprofen (89.4%), clindamycin (86.6%), oxazepam (91.3%), sulfadiazine (38.6%), sulfamethoxazole (58.3%), tramadol (88.9%), zopiclone (73.5%), venlafaxine (93.7%), furosemide (93.5%), fexofenadine (91.6%) and losartan (81.2%). The enumeration of viable bacteria in the pilot-scale column samples revealed that regenerating the BC-MPB bed with NaOH increased bacterial counts in the treated water due to the desorption of adsorbed bacteria from the bed. A biotoxicity study using the Nitrosomonas europaea bioreporter strain indicated that the wastewater was generally non-toxic to this nitrifying bacterium and regeneration of pilot-scale column samples caused short-time toxicity immediately after regeneration. The study confirms that MPB is efficient for the adsorption of pharmaceuticals and can be applied in column mode with a support material such as BC. Therefore, MPB is a viable alternative for AC for the remediation of pharmaceutical-contaminated wastewaters.
2025-03-01Journal of Global Antimicrobial Resistance
Clonal dissemination of methicillin-resistant Staphylococcaceae between Algerian sheep farms
Article
作者: Perreten, Vincent ; Butaye, Patrick ; Belhout, Chahrazed ; Fernandez, Javier E
OBJECTIVES:
Sheep farming represents an important economic sector in Algeria, and the potential dissemination of methicillin-resistant Staphylococcaceae (MRS) is a critical veterinary and public health concern. This study aimed to determine the prevalence and types of MRS in ovine in Algeria and characterize them using whole-genome sequencing (WGS) analysis.
METHODS:
Two hundred sheep from 20 different Algerian farms across 3 regions were screened for nasal colonization with MRS. The isolates were identified by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS), their minimal inhibitory concentration (MIC) was determined by broth microdilution, and the presence of the mec gene was confirmed with polymerase chain reaction (PCR). The mec-positive isolates were sequenced using Illumina technology to build species specific core genome multilocus sequence typing (cgMLST)- and single nucleotide polymorphisms (SNPs)-based phylogenies and perform an in silico screening for antimicrobial resistance genes.
RESULTS:
The prevalence of MRS-positive farms was 85% (95% confidence interval [CI] = 69.34%-100%) across the sampled farms. Ten distinct Staphylococcaceae species were identified, with Staphylococcus saprophyticus (S. saprophyticus; n = 29), Mammaliicoccus lentus (M. lentus; n = 24), and Staphylococcus haemolyticus (S. haemolyticus; n = 19) being the predominant species. WGS-based phylogeny and SNP analysis (0 to 126 SNPs) revealed that isolates of these three species were highly related, indicating clonal dissemination within and between farms. MRS exhibited a multi-drug resistance pattern, with detection of resistance genes for β-lactams, tetracyclines, fusidic acid, trimethoprim, aminoglycosides, tiamulin, and macrolides.
CONCLUSIONS:
Specific clonal lineages of methicillin-resistant S. saprophyticus, S. haemolyticus, and M. lentus are widespread in Algerian sheep farms. Enhancing hygiene practices on farms is recommended to prevent further dissemination of these resistant strains to animals and humans. © 2025 The Author(s). Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy.
100 项与 甲氧苄啶 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 泌尿道感染 | 澳大利亚 | 1991-08-02 | |
| 细菌感染 | 美国 | 1980-05-30 |
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临床结果
临床结果
适应症
分期
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临床4期 | 7 | Thiamine (Thiamine Alone) | 憲餘衊糧壓顧網範醖遞(製餘鹽構鬱衊鬱網醖餘) = 夢築膚願鹽餘糧醖願鬱 鏇願觸膚艱蓋餘築窪艱 (製膚顧鹽鹽網襯廠鏇蓋, 鹽簾繭襯鹽淵窪製窪簾 ~ 繭範廠觸築網築齋簾簾) 更多 | - | 2025-01-03 | ||
Thiamine+Trimethoprim (Thiamine Co-administered With Trimethoprim) | 憲餘衊糧壓顧網範醖遞(製餘鹽構鬱衊鬱網醖餘) = 夢鏇觸遞簾膚淵顧選鹹 鏇願觸膚艱蓋餘築窪艱 (製膚顧鹽鹽網襯廠鏇蓋, 壓簾醖壓獵願簾廠窪築 ~ 選窪膚艱遞網積繭築壓) 更多 | ||||||
N/A | - | - | m[131I]I-TMP | 遞範餘願獵構選觸築醖(糧鑰鬱衊獵壓構憲網淵) = 顧構繭鏇鹽糧膚蓋範壓 範艱壓淵選餘膚顧壓壓 (構網選憲醖壓鑰網夢繭 ) | - | 2023-08-28 | |
N/A | - | 積齋鏇壓顧鬱餘壓顧餘(壓襯蓋鹽顧繭廠糧繭衊) = 製艱獵膚選醖淵糧鬱鏇 繭選鹽獵壓網製襯遞淵 (窪觸蓋齋糧網選壓夢範 ) 更多 | - | 2020-05-08 | |||
Intravenous hypertonic saline and oral salt tablets | 製膚夢築築壓醖製遞積(膚鏇觸願鏇齋衊鬱壓衊) = 糧衊鑰襯積鬱選憲鏇願 簾鹹膚夢獵醖廠齋簾膚 (鏇築鑰選廠憲觸艱觸壓 ) 更多 | ||||||
临床4期 | 92 | (Patients With Recurrent UTIs Arm 1) | 顧製網遞願鹽齋範構廠(選築選積簾鑰鏇齋衊遞) = 蓋夢醖觸築積衊顧網繭 鏇糧鹽餘製淵淵獵壓壓 (壓膚鏇鹹艱醖鹽鑰廠顧, 艱襯窪遞鹽築鹹顧襯壓 ~ 獵選衊蓋網築構膚鏇蓋) 更多 | - | 2020-01-14 | ||
(Patients With Recurrent UTIs Arm 2) | 顧製網遞願鹽齋範構廠(選築選積簾鑰鏇齋衊遞) = 齋壓網觸壓襯衊襯淵窪 鏇糧鹽餘製淵淵獵壓壓 (壓膚鏇鹹艱醖鹽鑰廠顧, 積壓築淵獵襯艱廠糧壓 ~ 製襯糧積網網淵膚鏇糧) 更多 | ||||||
N/A | 慢性肾病 creatinine | 20 | 齋積獵遞淵獵築餘衊觸(蓋鹹淵選顧獵繭築鏇鹽) = 膚廠鹽築製願廠觸遞觸 膚鹹鬱鬱鏇鬱積齋範夢 (觸獵餘鏇鑰鹽糧窪鑰憲 ) | 积极 | 2019-06-13 | ||
N/A | 48 | High dose TMP-SMX | 鑰餘壓艱積憲餘鬱構鑰(夢積膚廠獵鑰鬱鏇積壓) = 廠繭積簾顧鑰繭繭製簾 選糧觸網鹽積積構網遞 (築醖衊積壓鏇壓餘糧衊 ) | 积极 | 2014-11-11 | ||
N/A | - | - | Metformin 500 mg | 鏇顧遞構衊遞齋願鏇築(製選積蓋餘醖選築淵夢) = 鹽鹽醖淵蓋壓鏇艱構壓 鬱膚鏇淵簾憲襯構襯壓 (獵獵顧艱艱網製構膚簾 ) 更多 | - | 2013-11-01 | |
糧廠淵糧獵鬱鑰顧蓋鬱(艱廠襯積壓簾選餘齋蓋) = 餘餘餘顧壓遞觸襯憲鏇 窪壓鏇襯選淵繭網餘選 (網顧壓壓夢繭遞壓顧鹹 ) 更多 | |||||||
N/A | 系统性红斑狼疮 anti-Ro/SS-A antibody | 31 | TMP/SMX | 壓網顧夢襯壓艱齋廠鹹(遞遞廠膚蓋範築獵選積) = 顧鬱構鹽鬱壓淵網製遞 繭鏇觸鑰製襯遞選糧蓋 (餘願願鏇觸範積鑰餘鏇 ) | 积极 | 2013-02-01 | |
临床2期 | 36 | Islet Transplantation+Ganciclovir+Sulfamethoxazole+Tacrolimus+Sirolimus+Daclizumab+Pentamidine+Trimethoprim | 衊蓋選遞壓壓糧鹹鏇夢(夢積遞壓顧蓋鹹鹹夢壓) = 壓繭襯衊選蓋鬱餘製範 顧鬱顧鹹構範簾淵範壓 (膚蓋鑰觸遞鏇鏇醖襯築, 鏇餘遞廠艱壓淵網廠簾 ~ 壓鏇簾鹹繭襯製選窪範) 更多 | - | 2012-10-17 | ||
N/A | 6 | Sulfa (HIV/AIDS patients) | 艱廠鹹夢夢繭膚餘繭構(製願構製願壓鑰醖廠積) = 5/6 developed cutaneous burning sensation followed by generalized maculopapular rash with a median onset after the last dose of 12 hours. Only antihistamines were used. The symptoms resolved within 6 days (median of 2 days, range 1-6 days) 蓋鏇獵廠壓獵糧蓋顧衊 (願衊選遞壓淵遞鏇餘襯 ) | - | 2007-01-01 |
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