Establish the First International Database on Semi-quantitative Values Obtained in Scintigraphy With Datscan? in Cadmium-Zinc-Telluride (CZT) Camera (VERITON-CT)

Datscan scintigraphy is a nuclear medicine examination allowing the diagnosis of neurodegenerative pathologies linked to damage to dopaminergic pathways, such as Parkinson's disease (essential for the differential diagnosis of essential tremor).

开始日期2025-07-30

申办/合作机构-

NCT04564092

/ Completed临床1期

A Phase 1, Non-randomised, Noncomparative, Open-label Study to Assess the Safety, Biodistribution, and Internal Radiation Dosimetry of a Single Dose of DaTSCAN™ Ioflupane (123I) Injection in Chinese Healthy Volunteers

This is a phase 1, single-centre, single-group, nonrandomized, noncomparative, open-label, single-dose study to evaluate the safety, biodistribution, internal radiation dosimetry, and effective dose of DaTSCAN™ ioflupane (123I) injection in Chinese Healthy Volunteers.

开始日期2021-05-13

申办/合作机构

GE Healthcare Holdings, Inc.

[+1]

EUCTR2019-000247-27-FR

/ Not yet recruiting临床3期

Non-inferiority study of the molecular imaging of dopamine transporters using [123I]-FP/CIT-SPECT and [18F] LBT-999-PET to distinguish between Parkinson’s Disease and Essential Tremor. - DATTEP

开始日期2021-03-31

申办/合作机构

Zionexa US Corp.

100 项与碘[123I]氟潘相关的临床结果

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100 项与碘[123I]氟潘相关的转化医学

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100 项与碘[123I]氟潘相关的专利（医药）

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339

项与碘[123I]氟潘相关的文献（医药）

2025-07-01·Revista espanola de medicina nuclear e imagen molecular

Justification and impact of SPECT ¹²³I-FP-CIT use in the differential diagnosis and management of movement disorders (MD) in a national referral hospital

Article

作者: Mitjavila Casanovas, M ; Ruiz Solís, S ; Canales Rodríguez, L

AIM:

To evaluate the adequacy and impact of ¹²³I-FP-CIT SPECT in the diagnosis and management of MD according to clinical guidelines.

PATIENTS AND METHODS:

Retrospective study involving 249 patients with suspected parkinsonism (PK) of uncertain origin. All underwent ¹²³I-FP-CIT SPECT and had a clinical follow-up of exceeding 12 months. Requests were classified based on their adherence to clinical guidelines. Variables analyzed included sex, age, justification for the request, management after SPECT, and final diagnosis.

RESULTS:

91.57% of the requests were appropriate, while 8.43% did not adhere to the guidelines. Diagnosis changed in 48.6% of cases and management in 70.68% after the scan, especially in inconclusive cases and initiation of therapy. General neurologists evaluated more cases and made more appropriate requests (96.3% vs 76.67%; p<0.001). However, MD specialists, despite less appropriate use of the guidelines, achieved a higher number of conclusive diagnoses in complex cases.

CONCLUSION:

¹²³I-FP-CIT SPECT has significant clinical impact when used in accordance with clinical guidelines, improving the diagnosis and management of MD. Unjustified scans reduce its utility. Collaboration between general neurologists and MD specialists is fundamental; the latter, although showing less adherence to guidelines in requesting the test, achieve a higher number of conclusive diagnoses in complex cases.

2025-06-04·CURRENT TOPICS IN MEDICINAL CHEMISTRY

Neurological Inflammation in Parkinsonism: Current PrognosticativeDiagnostics and Pitfalls

Article

作者: Sasidharan, Sreenivasan ; Gopinath, Subash C.B. ; Chen, Yeng ; Fakhri, Makram A. ; Lakshmipriya, Thangavel ; Salim, Evan T.

Parkinson's disease (PD) is a persistent neurological degenerative condition that cansignificantly alter one's quality of life. This condition affects the substantia nigra, the region of thebrain that contains dopamine-producing neurons. It is a disorder of the central nervous system thatarises when nerve cells, or neurons, in this brain area are damaged or die. Norepinephrine, anotherchemical messenger that aids in controlling primary physiological processes, such as heart rate andblood pressure, is also deficient in PD patients. The symptoms of PD can interfere with daily activitiesand include fatigue, walking difficulties, limb rigidity, and loss of smell. Researchers are strivingto identify a reliable biomarker for Parkinson's disease. Currently, the Food and Drug Administrationhas approved the radiotracer I-123-ioflupane injection followed by scanning (DATscan-SPECT) for precise analysis. To diagnose Parkinson's disease early, researchers are developingpredictive diagnostic techniques using various biomarkers. The right biosensor can recommend thebest personalized course of action to slow the progression of Parkinson's disease. This review highlightsthe strong performance of diagnostic biomarkers for Parkinson's disease and emphasizes theeffectiveness of the common immuno-, apta- and DNA-sensors for their efficient implementationsfor different biomarkers. Further, it also discusses the potential advantages and drawbacks associatedwith detection methods for improving high-performance diagnostics.

2025-03-01·Brain disorders (Amsterdam, Netherlands)

A proposal of visual assessment of serotonergic deficits in parkinsonian syndromes: An 123I-FP-CIT SPECT study

作者: Yoshioka, Masaru ; Sugimura, Yoko ; Takeda, Atsushi ; Totsune, Tomoko ; Tanaka, Hiroyasu ; Takahashi, Toshiaki ; Oizumi, Hideki ; Baba, Toru ; Nagamatsu, Ken-ichi

¹²³I-FP-CIT, primarily used for imaging dopamine transporters in the nigrostriatal pathway, also shows some affinity for the serotonin transporter (SERT), which is predominantly distributed in the raphe nuclei in the brainstem.Recent imaging studies have demonstrated that compared with Parkinson′s disease (PD), atypical parkinsonian syndromes (PS) exhibit pronounced SERT reduction using semiquant. methods.However, the utility of qual. visual assessment methods for SERT has been poorly discussed to date.The aims of this study were to propose a visual assessment grading system of brainstem ¹²³I-FP-CIT uptake and investigate the ability of this method to differentiate PD from PS.We analyzed the imaging data of 97 parkinsonian patients who underwent ¹²³I-FP-CIT SPECT.First, we graded ¹²³I-FP-CIT uptake in the midbrain and pons with a 4-degree scale and analyzed the interrater agreement of our grading method.Next, we compared the visual grading data of the PD (n = 59) and PS (n = 11) groups and analyzed the diagnostic utility of the qual. visual assessment method.The interrater agreement of the visual grading of ¹²³I-FP-CIT uptake among the three raters was moderate (Fleiss′ Kappa 0.480 for midbrain, 0.488 for pons).The patterns of ¹²³I-FP-CIT uptake in the pons differed significantly between patients with PD and PS (p = 0.035).The visual assessment-based classification showed 81.8 % sensitivity, 61.0 % specificity, 28.1 % pos. predictive value, and 94.7 % neg. predictive value in distinguishing PS from PD.Visual assessment of SERT abnormalities with ¹²³I-FP-CIT may contribute to differentiating PD and PS in clin. settings.

项与碘[123I]氟潘相关的新闻（医药）

2025-09-30

·EINPresswire

April - June 2025 | Potential Signals of Serious Risks/New Safety Information Identified by the FDA Adverse Event Reporting System (FAERS)

Acetaminophen-containing products Anaphylactic reaction FDA is evaluating the need for regulatory action. Aptryxol (desvenlafaxine) DaTscan (ioflupane I 123 injection) Desvenlafaxine extended-release tablets Effexor XR (venlafaxine extended-release) capsules Pristiq (desvenlafaxine) extended-release tablets Venlafaxine (venlafaxine hydrochloride) extended-release tablets False positive radioisotope investigation test result potentially secondary to a drug interaction with venlafaxine FDA is evaluating the need for regulatory action. Barium sulfate-containing products Entero Vu 24% (barium sulfate) oral suspension E-Z-Disk (barium sulfate) tablets Liquid E-Z-Paque (barium sulfate) oral suspension Readi-Cat 2 (barium sulfate) oral suspension Readi-Cat 2 Smoothie (barium sulfate) oral suspension Taglitol V (barium sulfate) oral suspension Varibar Honey (barium sulfate) oral suspension Varibar Nectar (barium sulfate) oral suspension Varibar Pudding (barium sulfate) oral paste Varibar Thin Honey (barium sulfate) oral suspension Varibar Thin Liquid (barium sulfate) oral suspension Anaphylactic reaction FDA is evaluating the need for regulatory action. Blincyto (blinatumomab) for injection Columvi (glofitamab-gxbm) injection Elrexfio (elranatamab-bcmm) injection Epkinly (epcoritamab-bysp) injection Imdelltra (tarlatamab-dlle) for injection Kimmtrak (tebentafusp-tebn) injection Lunsumio (mosunetuzumab-axgb) injection Talvey (talquetamab-tgvs) injection Tecvayli (teclistamab-cqyv) injection Progressive multifocal leukoencephalopathy FDA is evaluating the need for regulatory action. BRAF kinase inhibitors Braftovi (encorafenib) capsules Ojemda (tovorafenib) for oral suspension; tablets Tafinlar (dabrafenib) capsules; tablets Zelboraf (vemurafenib) tablets Gingival hypertrophy FDA is evaluating the need for regulatory action. Briumvi (ublituximab-xiiy) injection Kesimpta (ofatumumab) injection Acute hepatic failure The "Warnings and Precautions" section of the labeling was updated in August 2025 to include information about liver injury. Example: Briumvi labeling Briumvi (ublituximab-xiiy) injection Kesimpta (ofatumumab) injection Ocrevus (ocrelizumab) injection Ocrevus Zunovo (ocrelizumab and hyaluronidase-ocsq) injection Central nervous system infection FDA is evaluating the need for regulatory action. Crexont (carbidopa and levodopa) extended-release capsules Dhivy (carbidopa and levodopa) tablets Duopa (carbidopa and levodopa) enteral suspension Rytary (carbidopa and levodopa) extended-release capsules Sinemet (carbidopa and levodopa) tablets Sinemet CR (carbidopa and levodopa) sustained-release tablets Stalevo (carbidopa, levodopa and entacapone) tablets Vyalev (foscarbidopa and foslevodopa) injection Seizure FDA is evaluating the need for regulatory action. Crysvita (burosumab-twza) injection Hypercalcemia The "Dosage and Administration", "Warnings and Precautions" and "Adverse Reactions" sections of the labeling were updated in August 2025 to include information about hypercalcemia. Crysvita labeling Dexmedetomidine-containing products Dexmedetomidine injection Precedex (dexmedetomidine hydrochloride) injection Igalmi (dexmedetomidine) sublingual film Diabetes insipidus FDA is evaluating the need for regulatory action. Dupixent (dupilumab) injection Ocular infections, irritations, and inflammation FDA is evaluating the need for regulatory action. Eprontia (topiramate) oral solution Qudexy XR (topiramate) extended-release capsules Qsymia (phentermine and topiramate) extended-release capsules Topamax (topiramate) tablets Topamax Sprinkle (topiramate) capsules Trokendi XR (topiramate) extended-release capsules Hypersensitivity FDA is evaluating the need for regulatory action. Gavreto (pralsetinib) capsules Chylothorax FDA is evaluating the need for regulatory action. Glucagon-like peptide-1 (GLP-1) receptor agonists Adlyxin (lixisenatide) injection Bydureon (exenatide) for extended-release injectable suspension Bydureon BCise (exenatide extended-release) injectable suspension Byetta (exenatide) injection Mounjaro (tirzepatide) injection Ozempic (semaglutide) injection Rybelsus (semaglutide) tablets Saxenda (liraglutide) injection Soliqua 100/33 (insulin glargine and lixisenatide) injection Trulicity (dulaglutide) injection Victoza (liraglutide) injection Wegovy (semaglutide) injection Xultophy 100/3.6 (insulin degludec and liraglutide) injection Zepbound (tirzepatide) injection Intestinal obstruction and fecal impaction FDA is evaluating the need for regulatory action. Imbruvica (ibrutinib) capsules; tablets; oral suspension Nail and nail bed conditions (excluding infections and infestations) FDA is evaluating the need for regulatory action. MEK inhibitors Avmapki Fakzynja Co-pack (avutometinib capsules; defactinib tablets) Cotellic (cobimetinib) tablets Mekinist (trametinib) tablets; oral solution Mektovi (binimetinib) tablets Koselugo (selumetinib) capsules Gingival hypertrophy FDA is evaluating the need for regulatory action. Neffy (epinephrine nasal spray) Product storage error FDA is evaluating the need for regulatory action. Nurtec ODT (rimegepant) orally disintegrating tablets Zavzpret (zavegepant) nasal spray Anaphylactic reaction The "Contraindications" and "Warnings and Precautions" sections of the labeling were updated in August 2025 to include information about hypersensitivity reactions, including anaphylaxis. Example: Nurtec ODT labeling Rozlytrek (entrectinib) capsules; oral pellets Brugada syndrome FDA is evaluating the need for regulatory action. Sodium-glucose cotransporter-2 (SGLT2) inhibitors Fournier's gangrene FDA is evaluating the need for regulatory action. Teriparatide injection (a particular generic product) Device malfunction FDA is evaluating the need for regulatory action. Vizamyl (flutemetamol F18 injection) Anaphylactic reaction The "Warnings and Precautions" section of the labeling was updated in June 2025 to include information about anaphylaxis and other serious hypersensitivity reactions. Vizamyl labeling Legal Disclaimer: EIN Presswire provides this news content "as is" without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the author above.

上市批准生物类似药

2025-03-30

·SYNAPSE

GE HealthCare Completes Acquisition of Nihon Medi-Physics (NMP), a Leading Radiopharmaceutical Company in Japan

GE HealthCare has completed its acquisition of Sumitomo Chemical’s 50% stake in Nihon Medi-Physics (NMP), giving it full ownership. As part of GE HealthCare, NMP, already a leading radiopharmaceutical company in Japan, is positioned to enhance patient access to next-generation radiopharmaceuticals that enable detection and diagnosis of disease. CHICAGO--(BUSINESS WIRE)--Mar. 31, 2025-- GE HealthCare Technologies Inc. (GE HealthCare or the Company) (Nasdaq: GEHC) has completed its acquisition of the remaining 50% stake in Nihon Medi-Physics Co., Ltd (NMP), from Sumitomo Chemical, giving it full ownership. As part of GE HealthCare, NMP can further build on its expertise in developing and manufacturing proprietary and in-licensed radiopharmaceuticals used in single photon emission computed tomography (SPECT) and positron emission tomography (PET) molecular imaging procedures to detect and diagnose disease. Kevin O’Neill, President & CEO of GE HealthCare’s Pharmaceutical Diagnostics (PDx) segment, who will also become President of NMP, said: “We are delighted to welcome Nihon Medi-Physics to GE HealthCare, increasing our existing footprint and offering in Japan, where our contrast media and medical devices are used every day to enable imaging procedures across the country. Japan is on a path to becoming a leader in the $7 billion molecular imaging global market and a center of excellence for Asian markets. As part of GE HealthCare, NMP will play a key role in that journey, including bringing its deep expertise and scale to global innovators looking to bring next-generation radiopharmaceuticals to the Japan market and beyond.” NMP’s product portfolio includes GE HealthCare radiopharmaceuticals used to enable molecular imaging across neurology, cardiology and oncology procedures. NMP, headquartered in Tokyo, was formed in 1973 and generated revenues of 28.2B JPY (~$183M) in 2023. GE HealthCare acquired Amersham plc in 2004, and subsequently held a 50% stake in NMP. The Company expects this transaction to be neutral to Adjusted EPS in year one and accretive thereafter.

并购诊断试剂

2025-02-06

·化学经纬

书籍分享||新药化学全合成路线手册

内容介绍本书归纳和综述了新药的化学合成路线。覆盖范围为近5年美国FDA批准上市的新分子实体药共109个。针对每一个药物，本书给出了药物简介，药物化学结构信息，产品上市信息，药品专利保护和市场独占权保护信息，化学全合成路线和参考文献等。这些合成路线大多是目前制药工业中正在使用的化学合成工艺，有较高的实用性和学术价值。对参与反应的起始原料、中间体、反应产物都给出了详细的化学结构。每一步化学合成反应都给出了重要的化学试剂、催化剂、所使用的溶剂、合成反应条件及文献出处等。本书的特点是：作者从浩如烟海的科技文献中，精心挑选出最新、最有实用价值的合成方法，汇编成化学合成路线图，内容简洁，深入浅出，逻辑性强，容易理解，以最少的篇幅表达最多的技术信息，可帮助读者很快找到他们需要的药物合成方法及最可靠的原始科学论文。读者对象： 1.任何从事与化学合成、药物合成、精细化工相关专业的科研人员、企业管理人员。 2.有机化学专业、药学专业、生物制药专业等大专院校的高年级学生、研究生、教师及科研人员。 3.从事客户委托的药物原料与药物中间体合成的科研人员、企业管理人员。编辑推荐对于制药企业而言,一个好的药物全合成路线, 可以大大缩短生产周期,简化生产工艺,降低生产成本,节约能源,减少或消除对环境的化学污染与排放。本书为了顺应我国近年来生物制药及医药工业飞速发展的潮流编写的，详细介绍了近五年美国FDA批准上市的所有（109个）新分子实体药的化学全合成路线。这些全合成路线多数是国外制药厂目前正在使用的工艺，其经济效益及社会效益都是极为显著，因此本书既有较高的科学价值又有很大的实用性。作者简介陈清奇，旅美药学家和化学家，担任美国MedKoo生物医药科研公司总裁，同时兼任美国数家生物制药公司的技术顾问，中国国内数个大学的客座教授。研究领域为药物化学，纳米医学体外诊断技术。书籍目录 Abiraterone Acetate（醋酸阿比特龙）001 Aclidinium Bromide（阿克利溴铵）006 Afatinib（阿法替尼）009 Alcaftadine（阿卡他定）014 Alogliptin（阿格列汀）017 Apixaban（阿哌沙班）022 Apremilast（阿普斯特）028 Avanafil（阿伐那非）033 Axitinib（阿西替尼）038 Azilsartan Kamedoxomil（阿齐沙坦酯钾盐）044 Bazedoxifene（巴多昔芬）048 Bedaquiline（贝达喹啉）053 Belinostat（贝利司他）060 Boceprevir（波西普韦）064 Bosutinib（博舒替尼）071 Cabozantinib（卡博替尼）075 Canagliflozin（卡格列净）078 Carfilzomib（卡非佐米）083 Ceftaroline Fosamil（头孢洛林酯）087 Ceftolozane（噻呋特啰嗪）094 Ceritinib（色瑞替尼）098 Clobazam（氯巴占）101 Cobicistat（可比司他）104 Crizotinib（克里唑蒂尼）112 Dabigatran Etexilate Mesylate（甲磺酸达比加群酯）118 Dabrafenib（达拉菲尼）123 Dapagliflozin（达格列净）127 Dasabuvir（达沙布韦）132 Deferiprone（去铁酮）136 Dienogest（地诺孕素）138 Dolutegravir（度鲁特韦）141 Droxidopa（屈昔多巴）145 Efinaconazole（艾氟康唑）149 Eliglustat（依利格鲁司特）152 Elvitegravir（埃替格韦）155 Empagliflozin（依帕列净）161 Enzalutamide（恩杂鲁胺）166 Eribulin Mesylate（甲磺酸艾日布林）168 Eslicarbazepine Acetate（艾利西平醋酸酯）175 Estradiol Valerate（雌二醇戊酸酯）180 Ezogabine（依佐加滨）185 Finafloxacin（非那沙星）193 Fingolimod Hydrochloride（盐酸芬戈莫德）197 Florbetapir F 18（氟比他匹）205 Flutemetamol F 18（富特米他）211 Gabapentin Enacarbil（加巴喷丁恩那卡比）214 Gadobutrol（钆布醇）218 Gadoterate Meglumine（钆特酸葡甲胺）224 Ibrutinib（依鲁替尼）227 Icatibant（艾替班特）232 Idelalisib（艾代拉里斯）234 Indacaterol （茚达特罗）236 Ingenol Mebutate（巨大戟醇甲基丁烯酸酯）240 Ioflupane 123I（碘[123I]氟潘）242 Ivacaftor（依瓦卡特）247 Ledipasvir（雷迪帕韦）250 Linaclotide（利那洛肽）259 Linagliptin（利拉利汀）261 Lomitapide（洛美他派）267 Lorcaserin（氯卡色林）270 Lucinactant（芦西纳坦）274 Luliconazole（卢立康唑）276 Lurasidone（鲁拉西酮）279 Macitentan（马西替坦）283 Miltefosine（米替福新）286 Mipomersen Sodium（米泊美生钠）290 Mirabegron（米拉贝隆）292 Naloxegol（纳罗克格）296 Netupitant（奈妥吡坦）299 Nintedanib（尼达尼布）303 Olaparib（奥拉帕尼）307 Olodaterol（奥达特罗）311 Omacetaxine Mepesuccinate（高三尖杉酯碱）315 Ombitasvir（艾姆伯韦）319 Ospemifene（奥培米芬）323 Paritaprevir（帕瑞它韦）327 Pasireotide（帕瑞肽）331 Peramivir（帕拉米韦）333 Perampanel（吡仑帕奈）337 Pirfenidone（吡非尼酮）343 Pomalidomide（泊马度胺）345 Ponatinib（泊那替尼）351 Regorafenib（瑞戈非尼）355 Rilpivirine（利匹韦林）357 Riociguat（利奥西呱）366 Rivaroxaban（利伐沙班）370 Roflumilast（罗氟司特）378 Ruxolitinib（鲁索替尼）384 Simeprevir（司美匹韦）388 Sofosbuvir（索非布韦）396 Suvorexant（苏沃雷生）401 Tafluprost（他氟前列腺素）405 Tasimelteon（他司美琼）409 Tavaborole（它瓦波罗）413 Tedizolid Phosphate（磷酸特地唑胺）415 Telaprevir（替拉瑞韦）418 Teriflunomide（特立氟胺）426 Ticagrelor（替格瑞洛）430 Tofacitinib（托法替尼）438 Trametinib（曲美替尼）443 Umeclidinium（芜地溴铵）447 Vandetanib（凡德他尼）450 Vemurafenib（威罗菲尼）456 Vilanterol（维兰特罗）460 Vilazodone Hydrochloride（盐酸维拉佐酮）463 Vismodegib（维莫德吉）468 Vorapaxar（沃拉帕沙）470 Vortioxetine（沃替西汀）473 附录1本书使用的期刊名称缩写表477 附录2专利文献代码481 附录3美国药品专利中的用途代码定义484 附录4美国药品市场独占权代码定义530 附录5美国FDA于2010—2014批准上市的药物名单563 英文索引607 中文索引611 CAS登记号索引613 下载方式现在，这份资料分享给大家。小编在公众号设置了自动回复功能，在公众号后台回复关键词：新药全合成 ●书籍分享||有机氧化反应原理与应用 ●书籍分享||有机卤化反应原理及应用 ●推荐合成书籍【有机缩合反应原理与应用】 ●推荐合成书籍【有机环合反应原理与应用】 ●书籍分享||有机还原反应原理与应用 ●ChemDraw使用让你从化学菜鸟变成老鸟 ●干货分享||有机合成: 策略与控制 ●干货分享||有机合成工艺研发-副反应抑制法 ●基础有机化学(邢其毅)第3、4版教材+习题解析 ●ChemDrawV20最新版详细安装图文教程 ●干货分享||核磁共振二维谱 ●书籍分享||全合成中的经典:更多的目标、战略和方法 ●书籍分享||实用药物化学 ●书籍分享||基于模仿创新的小分子药物发明 ●书籍分享||制药工艺开发-目前的化学与工程挑战 ●书籍分享||手性合成:不对称反应及其应用(第5版) ●书籍分享||新药研发案例研究--明星药物如何从实验室走向市场 ●书籍分享||英汉·汉英化学化工词汇 ●书籍分享||有机化学结构与功能（第四版） ●书籍分享||过渡金属有机化学(原著第6版） ●重磅书籍分享||不对称催化基础 ●书籍分享||药物设计学-唐赟

上市批准高管变更

100 项与碘[123I]氟潘相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D10014	碘[123I]氟潘	V09AB03	DB08824

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适应症	国家/地区	公司	日期
路易体病	美国	GE Healthcare, Inc.	2022-11-01
诊断试剂	日本	Nihon Medi-Physics Co., Ltd.	2013-09-20
特发性震颤	韩国	Samyoung Unitech Co. Ltd.	2011-04-15
帕金森病	韩国	Samyoung Unitech Co. Ltd.	2011-04-15
帕金森障碍	欧盟	GE Healthcare B.V.	2000-07-27
帕金森障碍	冰岛	GE Healthcare B.V.	2000-07-27
帕金森障碍	列支敦士登	GE Healthcare B.V.	2000-07-27
帕金森障碍	挪威	GE Healthcare B.V.	2000-07-27

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适应症	最高研发状态	国家/地区	公司	日期
多系统萎缩	临床3期	中国	GE Healthcare Holdings, Inc.	2020-06-28
多系统萎缩	临床3期	中国	GE Healthcare B.V.	2020-06-28
多系统萎缩	临床3期	中国	通用电气药业（上海）有限公司	2020-06-28
多系统萎缩	临床3期	中国	GE Healthcare Pvt Ltd.	2020-06-28
进行性核上性麻痹	临床3期	中国	GE Healthcare Pvt Ltd.	2020-06-28
进行性核上性麻痹	临床3期	中国	通用电气药业（上海）有限公司	2020-06-28
进行性核上性麻痹	临床3期	中国	GE Healthcare B.V.	2020-06-28
进行性核上性麻痹	临床3期	中国	GE Healthcare Holdings, Inc.	2020-06-28
阿尔茨海默症	临床3期	德国	GE Healthcare Holdings, Inc.	2003-11-01
血管性痴呆	临床3期	德国	GE Healthcare Holdings, Inc.	2003-11-01

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适应症

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT04193527 (CTgov)	临床3期	特发性震颤 \| 进行性核上性麻痹 \| 多系统萎缩 ... 更多	172	DaTSCAN™ ioflupane (123I) (DaTSCAN™ Ioflupane: Participants With Parkinsonian Syndrome (PS))	網壓膚齋積糧襯壓遞壓 = 獵獵憲淵築鹹鹽鏇蓋鬱壓齋淵繭襯鏇築選憲憲 (襯構鑰鬱衊獵觸鏇繭鏇, 襯鏇廠願觸憲觸簾蓋顧 ~ 遞艱餘淵顧鹽齋餘顧衊) 更多	-	2023-10-16
				DaTSCAN™ ioflupane (123I) (DaTSCAN™ Ioflupane: Participants With Essential Tremor (ET))	願繭憲選淵鑰繭壓選選 = 願願網構製餘衊艱壓鏇築壓夢構膚衊醖獵艱製 (構齋蓋鬱願遞餘糧製窪, 築觸積餘構夢膚鬱顧膚 ~ 範構鏇選襯鏇鏇夢襯衊) 更多
NCT04564092 (CTgov)	临床1期	-	9	DaTSCAN™ Ioflupane (123I) Injection	鏇壓憲鬱膚鹹淵夢窪顧 = 遞蓋淵築獵積夢築範鹽廠製觸襯衊廠鬱艱憲遞 (積壓醖窪夢醖膚衊膚窪, 襯築憲簾壓鹹繭願餘構 ~ 鏇願廠簾鏇齋觸選構膚) 更多	-	2023-08-02
AAN2022	N/A	REM睡眠行为障碍	34	123I-FP-CIT	網憲艱繭膚衊積憲鑰鏇(壓鹹襯觸壓齋簾餘鏇糧) = 簾範窪醖鬱鹽糧鬱積鹹鬱糧築醖憲艱蓋製憲積 (醖窪醖範艱鏇構鹹夢艱 ) 更多	-	2022-05-03
				123I-FP-CIT	網憲艱繭膚衊積憲鑰鏇(壓鹹襯觸壓齋簾餘鏇糧) = 齋糧範醖窪製蓋壓艱網鬱糧築醖憲艱蓋製憲積 (醖窪醖範艱鏇構鹹夢艱 ) 更多
NCT01141023 (PPMI, EAN2019)	临床2期	帕金森病 [123I]FP-CIT SPECT \| MDS-UPDRS	389	[123I]FP-CIT SPECT (PD patients with drooling)	鬱範蓋獵範鏇憲淵膚鏇(鬱膚夢醖製範膚餘齋鏇): HR = 1.823 (95% CI, 1.176 ~ 2.827), P-Value = 0.007	积极	2019-06-27
				[123I]FP-CIT SPECT (PD patients without drooling)
NCT01141023 (PPMI, EAN2019)	临床2期	帕金森病 [123I]FP-CIT SPECT	390	[123I]FP-CIT (PD patients with gait impairment)	遞獵醖鹹憲壓構齋鑰製(膚鏇夢鹽範醖鏇夢淵網) = 製窪鏇憲鹹鑰夢壓鹹鑰壓鑰鹹繭糧壓鑰醖願衊 (襯齋夢鹽遞構鏇鹽繭鹽 )	积极	2019-06-27
NCT01141023 (PPMI, AAN2015)	临床2期	帕金森病 dopamine transporter (DAT)	167	123-I Ioflupane SPECT	蓋鑰鹹壓齋淵選醖積網(顧醖糧襯襯淵壓憲顧壓) = 壓網鹽網網鑰獵艱鏇鑰鹹遞艱餘獵廠糧繭鬱膚 (膚鑰壓鹽鬱夢壓鏇壓範 )	积极	2015-04-06
NCT01141023 (PPMI, SNMMI2014)	临床2期	帕金森病 dopamine transporter SPECT imaging	298	123-I Ioflupane SPECT	淵築餘鹽淵簾觸艱觸遞(觸艱簾餘憲網網蓋齋鹽) = 壓顧選鏇壓齋築鹹壓糧艱遞餘繭範範醖願壓窪 (廠醖鹹醖淵製鏇鏇淵憲, 15.6%)	积极	2014-11-05
				123-I I-Ioflupane (PD subjects with 3 SPECT scans)	淵築餘鹽淵簾觸艱觸遞(觸艱簾餘憲網網蓋齋鹽) = 願鹽製糧糧糧簾壓鏇網艱遞餘繭範範醖願壓窪 (廠醖鹹醖淵製鏇鏇淵憲, 15.6%)
AAIC 12008 \| AAIC 22008	N/A	路易体病 123I-FP-CIT SPECT	325	123I-FP-CIT SPECT	鹽選積選膚顧鬱餘艱憲(鏇廠憲獵鹹顧糧壓鏇鹹) = 網遞遞餘顧夢憲艱膚網鑰鹹遞鏇艱糧艱積夢窪 (構蓋鹹觸鑰獵簾簾膚選 ) 更多	积极	2008-07-01