预约演示
更新于：2025-05-16
Brilliant Blue G
亮蓝G
更新于：2025-05-16
概要
基本信息
非在研机构- |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2019-12-20), |
最高研发阶段(中国)- |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C47H49N3NaO7S2 |
InChIKeyRWFXCYWTHJDCMJ-UHFFFAOYSA-N |
CAS号6104-58-1 |
关联
11
项与 亮蓝G 相关的临床试验JPRN-UMIN000031510
Staining with brilliant blue G for the internal limiting membrane - Brilliant blue G stains the internal limiting membrane
JPRN-UMIN000031906
Evaluation of safety of Brilliant Blue G for inner limiting membrane peeling in patients with vitreomacular diseases - Safety of Brilliant Blue G for inner limiting membrane peeling
NCT03020459
Comparing the Surgical Outcomes of Internal Limiting Membrane Peeling-reposition Versus Peeling in Idiopathic Macular Holes: A Randomized Controlled Trial
100 项与 亮蓝G 相关的临床结果
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100 项与 亮蓝G 相关的转化医学
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100 项与 亮蓝G 相关的专利（医药）
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1,474
项与 亮蓝G 相关的文献（医药）2025-08-01JOURNAL OF MOLECULAR STRUCTURE
β-cyclodextrin coated cobalt ferrite nanoparticles (CoFe2O4@BCD NPs) synthesis & performance evaluation for effective dye adsorption
作者: Jose Teran, Francisco ; Boutamine, Zineb ; Alleg, Safia ; Navio, Cristina ; Ortega, Daniel ; Ayachi, Ahmed Abdelhakim ; Alcazar Fuoli, Laura ; Hafirassou, Anissa Zohra
In this study, Beta-Cyclodextrin Coated Cobalt Ferrite nanoparticles (CoFe2O4@BCD NPs) are synthesized and characterized to assess their efficacy in enhancing the adsorption of Coomassie Brilliant Blue dye.The nanoparticles, which is synthesized by coprecipitation method, exhibit an average size of 14 nm and a magnetic saturation of 48.53 A·m2/kg.Rapid adsorption kinetic is observed with 87 % of the removed dye within the first 3 min while achieving saturation within 5 min corresponding to a maximum adsorption capacity of 175.81 mg/g.The adsorption process conforms to a pseudo-second-order kinetic model (R2=1) and remains stable under varying pH, temperature, and saline/glucose conditions even though minor fluctuations in adsorption capacity are noted.Regeneration tests show that the CoFe2O4@BCD NPs retain their performance over five cycles.Cytotoxicity assays on the A549 human alveolar adenocarcinoma cell line confirms their biocompatibility.With their rapid, high-capacity adsorption, magnetic properties, and biocompatibility, CoFe2O4@BCD NPs offer significant potential for future water remediation applications.
2025-06-01JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
A novel intraoperative infection detecting liquid for medication-related osteonecrosis of the jaw
Article
作者: Hokugo, Akishige ; Kubo, Masahiro ; Takeda, Daisuke ; Hasegawa, Takumi ; Shigeoka, Manabu ; Yoneda, Akiko ; Akashi, Masaya ; Arimoto, Satomi ; Shigenaga, Kazuki
Medication-related osteonecrosis of the jaw (MRONJ) is a serious complication by antiresorptive medications and the treatment of MRONJ remains unclear. The present study developed a novel intraoperative infection-detecting liquid for MRONJ using various widely available and inexpensive dyes to detect infected bone areas. First, we performed a preliminary experiment using five dyes in a rat model of MRONJ. Eighteen female Sprague-Dawley (SD) rats were assigned to six dye groups: undyed, acid red, Brilliant Blue, phloxine, methylene blue, and Rose Bengal. Based on visual inspection and histological findings, Brilliant Blue and phloxine were selected for further evaluation. Next, twenty-eight SD rats were assigned to the control, undyed, Brilliant Blue, and phloxine groups and applied to experimentally induced MRONJ. The stained area was completely removed, and the bone defect was closed with sutures. Eight weeks after surgery, soft-tissue evaluation and histological and microcomputed tomography analyses were performed. The area of oral mucosal swelling was significantly smaller in the phloxine group than in the undyed and Brilliant Blue groups. The osteonecrosis area in the phloxine group was significantly smaller than that in the undyed group. These results suggest that phloxine staining is helpful for intraoperative differentiation of infected bone from normal bone.
2025-06-01SEPARATION AND PURIFICATION TECHNOLOGY
Topological defect-structured hydrogel membranes for high-efficiency permeation and selective separation
作者: Ma, Youwei ; Gao, Xusheng ; Gao, Ningning ; Lin, Ligang ; Zhao, Kongyin ; Li, Qi ; Xu, Lijing ; Wang, Minglin ; Chen, Min
Biomass-derived hydrogel membranes that derived from natural polymers exhibit excellent anti-fouling properties, environmental sustainability, and mol./ionic separation performance.However, their applications are significantly hindered by poor mech. strength, excessive swelling behavior, and low permeation flux.In this study, we report the polymer structures featuring topol. defects through the in-situ synthesis of copper oxychloride particles (CP, Cu2(OH)3Cl) within the hydrogel membranes.The functional hydrogel membrane, designated CP-CuCaAlg, was prepared using a strategy that modulates topol. defects through secondary crosslinking.Not only does this approach enhances the mech. and anti-swelling properties of the resulting membrane, it also increases the internal network spacing, thereby effectively overcoming the trade-off between the selective separation and permeation.The CP-CuCaAlg membrane exhibits exceptional dye/salt separation performance, achieving a dye rejection rate of approx. 99.0 % towards Coomassie Brilliant Blue (CBB) and Direct Red 23 (DR).Furthermore, the salt rejection rate for sodium chloride (NaCl) remains below 10.0 %, while the permeate flux achieves an impressive value of 57.63 L m-2h-1 bar-1.We anticipate that our hydrogel membranes featuring the topol. defect structures and high separation efficiency will provide a promising option for the effective treatment of dye wastewater.
100 项与 亮蓝G 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 眼科外科手术 | 美国 | 2019-12-20 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 纤维化 | 临床前 | - | - | 2013-04-01 |
| 肾炎 | 临床前 | - | - | 2013-04-01 |
| 视网膜变性 | 临床前 | 日本 | 2011-04-01 |
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临床结果
临床结果
适应症
分期
评价
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N/A | - | (No-dye group) | 願選齋鹽鹹憲鏇廠願壓(鬱鬱願積範獵鑰鑰顧獵) = The rates of changes in deficiency of EZ at 1 and 6 months compared with baseline in BBG group were significantly greater than those in no dye group 顧壓夢構夢網餘鏇憲壓 (繭積願構願蓋憲鏇餘鹽 ) 更多 | - | 2019-07-01 | ||
(BBG group) | |||||||
N/A | 输尿管梗阻 P2X7 receptor | - | (Sham operated and saline infusion) | 鹽選網繭製壓糧鏇鏇積(醖蓋淵餘鏇膚襯構醖夢) = 淵醖廠鹽鑰觸願構襯醖 餘鏇鬱糧範淵膚鹽窪壓 (餘築範顧襯築膚觸壓鏇 ) 更多 | 积极 | 2012-10-30 | |
Sham and BBG 25mg/kg intravenously (IV) | 鹽選網繭製壓糧鏇鏇積(醖蓋淵餘鏇膚襯構醖夢) = 夢遞製蓋鏇糧構糧繭廠 餘鏇鬱糧範淵膚鹽窪壓 (餘築範顧襯築膚觸壓鏇 ) 更多 | ||||||
N/A | - | 範簾選鹽壓鑰夢膚獵襯(顧鑰願壓製膚餘鏇觸顧) = 艱顧繭範夢築窪鏇簾鑰 遞觸遞積糧窪餘襯憲醖 (積艱願築膚鬱積築鹽蓋 ) 更多 | - | 2011-04-01 | |||
Vehicle (0.9% NaCl) | 願窪醖願夢積遞齋選膚(齋鹹膚醖構醖鏇繭膚襯) = 獵鬱觸範餘鑰窪遞構網 窪襯鏇選齋膚齋構鏇願 (廠遞獵願蓋廠襯淵醖鹹 ) | ||||||
N/A | - | 憲鑰廠糧窪襯壓膚積網(憲構遞鑰顧簾遞選簾醖) = 範築艱餘鏇鹹鏇廠鏇糧 選窪壓築衊選構積鹹鹹 (獵鹽網網鬱鑰願艱獵繭 ) | 积极 | 2011-04-01 | |||
N/A | 视网膜穿孔 辅助 | - | 願鹹顧簾鏇願齋範憲壓(鑰選網餘憲顧蓋範膚淵) = 壓壓鹽網願壓築襯鏇蓋 憲艱願鏇衊觸築糧餘淵 (構鹹齋構積夢繭選餘鏇 ) 更多 | - | 2010-10-18 | ||
願鹹顧簾鏇願齋範憲壓(鑰選網餘憲顧蓋範膚淵) = 網夢願憲艱選選遞齋壓 憲艱願鏇衊觸築糧餘淵 (構鹹齋構積夢繭選餘鏇 ) 更多 | |||||||
N/A | 8 | 網鬱構醖獵範積鹽觸窪(膚艱窪憲繭顧壓餘醖艱) = 憲獵網築遞築鬱範糧鑰 膚鏇積壓膚鏇製積積構 (淵顧積齋憲顧膚蓋顧選 ) 更多 | 积极 | 2010-04-01 | |||
(SF6 gas tamponade) | 網鬱構醖獵範積鹽觸窪(膚艱窪憲繭顧壓餘醖艱) = 夢網醖網膚選繭積製選 膚鏇積壓膚鏇製積積構 (淵顧積齋憲顧膚蓋顧選 ) 更多 | ||||||
N/A | - | 繭蓋襯艱顧積築餘觸積(構壓齋顧廠構鏇簾鹽構) = 廠願鬱範蓋齋鹽選範壓 糧鬱願衊鹽鏇蓋繭淵鏇 (廠膚鑰範齋觸襯壓窪選 ) 更多 | 积极 | 2009-10-26 | |||
繭蓋襯艱顧積築餘觸積(構壓齋顧廠構鏇簾鹽構) = 選蓋廠鹽網壓鑰壓襯願 糧鬱願衊鹽鏇蓋繭淵鏇 (廠膚鑰範齋觸襯壓窪選 ) 更多 |
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