预约演示
更新于：2025-05-16
Perflutren lipid microsphere
全氟丙烷脂质微球
更新于：2025-05-16
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2001-07-31), |
最高研发阶段(中国)批准上市 |
特殊审评- |
登录后查看时间轴
结构/序列
分子式C3F8 |
InChIKeyQYSGYZVSCZSLHT-UHFFFAOYSA-N |
CAS号76-19-7 |
关联
66
项与 全氟丙烷脂质微球 相关的临床试验NCT06024772
Prostate Cancer Diagnosis by Multiparametric Ultrasound (Clinical)
NCT06066723
A Cross-sectional Pilot Study of 19F MRI in Healthy Children and Children With Mild Cystic Fibrosis Lung Disease
NCT06797193
Invoking Subharmonics and Subharmonic Aided Pressure Estimation (SHAPE) for Identifying Portal Hypertension
100 项与 全氟丙烷脂质微球 相关的临床结果
登录后查看更多信息
100 项与 全氟丙烷脂质微球 相关的转化医学
登录后查看更多信息
100 项与 全氟丙烷脂质微球 相关的专利（医药）
登录后查看更多信息
2,321
项与 全氟丙烷脂质微球 相关的文献（医药）2025-07-01AMERICAN JOURNAL OF OPHTHALMOLOGY
Colour Doppler and Contrast-Enhanced Ultrasound Characteristics in Degenerative Retinoschisis and Retinal Detachment
Article
作者: LE, Matthew ; Macri, Carmelo ; Gun, Meegan ; Sammouh, Fady ; Lee, Yong Min ; Chan, Weng Onn ; Paris, Jai ; Lim, Wanyin
PURPOSE:
To investigate and compare the characteristics of colour Doppler ultrasound (CDUS) and contrast-enhanced ultrasound (CEUS) in degenerative retinoschisis (RS) and rhegmatogenous retinal detachment (RD).
DESIGN:
Prospective, observational case series.
METHODS:
We prospectively enrolled patients with degenerative RS, acute RD, or chronic RD at two tertiary centres from January 2024 to January 2025. Patients underwent clinical examination, ultrawide field photography and optical coherence tomography (OCT), and CDUS, followed by CEUS with Definity® microbubbles. Ultrasound characteristics between groups were compared.
RESULTS:
We included 65 eyes from 47 patients (25 male, median age 61.8). There were 51 eyes with RS, 6 eyes with acute RD, and 6 eyes with chronic RD. CDUS revealed no pre-contrast doppler flow in any RS, while all acute RD cases demonstrated doppler flow. CEUS displayed mild microbubble uptake in 18 RS cases (median bubble count of 2), whereas all RD cases exhibited florid uptake (median bubble count of 48.2). Compared to RS, acute RD cavities had significantly higher elevation from sclera (by 6.0 CI 2.8-9.2 mm), longer cavity lengths (by 9.8 CI 7.2-12.5), and greater membrane thickness (by 0.89 CI 0.6-1.2 mm). Chronic RD were significantly thicker than RS membranes (by 0.40 CI 0.2-0.6 mm) but were no longer or with greater elevation. Pixelated image analysis showed compared to RS, acute RD showed a higher average total particle count (by 45.83 units), larger particle size (by 66.3 pixels), and greater total particle area (by 3138 pixels). Chronic RD cases had mixed CDUS and CEUS findings.
CONCLUSIONS:
CDUS features differentiating between degenerative RS and RD included the lack of doppler flow in RS, higher and longer cavities in acute RD, and thicker membranes in acute and chronic RD. CEUS features differentiating RS and RD included florid microbubble contrast enhancement in acute RD. These findings could aid in the investigation of cases with diagnostic uncertainty.
2025-06-01FLUID PHASE EQUILIBRIA
Accurate calculation and reliable prediction of second virial coefficients for nonpolar mixtures
作者: Qin, Kang ; Xu, Liu ; Duan, Yuan-Yuan
The virial equation of state has a theor. advantage in the calculations of mixturesThe second mixture virial coefficients are with the theor. rigid mixing rules and composed of the second virial coefficients for pure fluids and the cross second virial coefficientsBased on the generalized corresponding state principle second virial coefficient model for pure fluids we proposed before, the generalized cross second virial coefficient models were established with three characteristic parameters for nonpolar binaries in this work.The calculation of the mixture critical temperature requires the binary interaction coefficients (kij).The mixture acentric factor was determined by the arithmetic mean.The mixture critical pressure could be calculated without the critical sp. volumeFor the most sensitive mixing rule of the mixture critical temperature, the kij was optimized for 145 nonpolar binaries.An easily accessible characteristic correlating parameter, the reduced diameter, was proposed to develop the predictive kij correlations for common nonpolar binaries.Due to the complex intermol. interactions between two different mols., the kij correlations were proposed resp. for alkane/alkane binaries, nonpolar binaries containing fluorocarbon, nonpolar binaries containing nitrogen or oxygen, nonpolar binaries containing simple fluids, nonpolar binaries containing carbon dioxide and nonpolar binaries containing neon.Our work was validated to perform satisfactorily from the comparison with the Chueh-Prausnitz kij correlation, Fender-Halsey kij correlation, and Meng kij correlation.Together with our previous work, this work could accurately calculate and reliably predict the second virial coefficients for common nonpolar mixtures
2025-06-01Computational and Theoretical Chemistry
Electron and positron impact ionization cross sections of neutral molecular species dissociating from C4F7N and its mixtures
作者: Geetha, D. ; Gupta, Dhanoj
The electron and positron impact ionization cross sections are reported for neutral fragments originating from C4F7N and their mixture with air, CO2, and N2 using the Binary-Encounter Bethe (BEB) method and its variants, such as BEB-W and BEB-B.The neutral targets studied are HF, CO, CO2, COF2, CHF3, CF3, CF4, C2F4, C2F6, C3F6, C3F8, C4F6, C4F8, C4F10, CN, HCN, CFN, C2N2, C2FN, C2F3N, C3F3N, C3F4N, C3F5N mols.The results for most of the targets for electron imapct ionization compare well with the available exptl. and theor. results.However, for most of the mols., the estimates of positron impact ionization are the first attempt.The correlation of the maximum ionization cross section for both electrons and positrons with the polarizability and the number of electrons of the target gave a good correlation fit.The cross section data presented in this article are important for C4F7N plasma.
研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 心脏病 | 中国 | 2022-11-15 | |
| 造影剂 | 美国 | 2001-07-31 |
未上市
10 条进展最快的记录, 后查看更多信息
登录
| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 慢性劳累性骨筋膜室综合征 | 临床3期 | 美国 | 2020-07-01 | |
| 肾脏疾病 | 临床3期 | 中国 | 2017-11-10 | |
| 肾脏疾病 | 临床3期 | 中国 | 2017-11-10 | |
| 肾细胞癌 | 临床3期 | 中国 | 2017-11-10 | |
| 肾细胞癌 | 临床3期 | 中国 | 2017-11-10 | |
| 肝病 | 临床3期 | 中国 | 2017-09-21 | |
| 肝病 | 临床3期 | 中国 | 2017-09-21 | |
| 肝细胞癌 | 临床3期 | 美国 | 2016-04-01 | |
| 心脏衰竭 | 临床2期 | 美国 | 2017-06-01 | |
| 子宫附件疾病 | 临床1期 | 美国 | 2017-08-01 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
临床1/2期 | 36 | NH002 (Cohort 1) | 顧築齋艱窪範膚鑰獵艱(醖糧鏇齋衊鏇構廠築繭) = 遞醖齋壓選壓憲衊醖夢 獵範齋窪鏇艱遞艱鬱衊 (繭觸夢齋廠選憲糧餘窪, 19.37) 更多 | - | 2024-12-20 | ||
NH002 (Cohort 2) | 顧築齋艱窪範膚鑰獵艱(醖糧鏇齋衊鏇構廠築繭) = 願糧憲鏇襯鹽餘齋壓壓 獵範齋窪鏇艱遞艱鬱衊 (繭觸夢齋廠選憲糧餘窪, 24.07) 更多 | ||||||
临床2/3期 | 56 | Intravitreal Tissue Plasminogen Activator (TPA) | 鑰窪鬱夢齋範窪構膚艱(憲淵鏇範壓製窪構壓膚) = 繭鏇窪選醖壓顧鹹觸鹽 鏇醖構襯餘遞築廠糧鑰 (範觸憲糧壓鏇艱獵艱積 ) | 积极 | 2024-12-01 | ||
Perfluoropropane (C3F8) | 鑰窪鬱夢齋範窪構膚艱(憲淵鏇範壓製窪構壓膚) = 遞憲積獵窪艱鏇鑰網襯 鏇醖構襯餘遞築廠糧鑰 (範觸憲糧壓鏇艱獵艱積 ) | ||||||
临床2/3期 | 56 | 範鏇壓衊鏇餘夢繭壓糧(積製夢鏇糧觸餘壓構膚) = 廠鹽繭壓蓋製鹹齋窪構 鹹構壓鏇範獵廠窪築鏇 (繭鑰壓顧獵艱願醖衊鑰 ) | 积极 | 2024-09-19 | |||
TPA | 範鏇壓衊鏇餘夢繭壓糧(積製夢鏇糧觸餘壓構膚) = 襯構範窪壓襯觸製鬱網 鹹構壓鏇範獵廠窪築鏇 (繭鑰壓顧獵艱願醖衊鑰 ) | ||||||
N/A | 6 | 築鏇鏇鑰蓋簾齋醖壓鬱 = 襯積蓋願鹽範簾夢淵鏇 顧蓋簾選憲夢壓築壓鏇 (觸糧鏇餘積築衊齋鹽淵, 積選鏇構遞築積廠繭製 ~ 積鏇繭獵壓蓋醖醖醖餘) 更多 | - | 2024-08-26 | |||
临床1期 | - | - | perflutren lipid microsphere injection (DEFINITY®) (Male subjects) | 夢觸範糧齋範鹽醖餘鬱(繭廠觸積選積衊獵顧鬱) = 鏇窪蓋廠積選蓋鬱製壓 構糧艱選鏇壓願觸餘壓 (觸鏇顧積餘窪襯艱獵艱 ) 更多 | - | 2024-01-02 | |
perflutren lipid microsphere injection (DEFINITY®) (Female subjects) | 夢觸範糧齋範鹽醖餘鬱(繭廠觸積選積衊獵顧鬱) = 艱夢鏇膚憲醖遞鏇範廠 構糧艱選鏇壓願觸餘壓 (觸鏇顧積餘窪襯艱獵艱 ) 更多 | ||||||
临床3期 | 131 | Logiq E9 Scanner (Contrast-enhanced ultrasound)+Ultrasound contrast agent (Contrast-enhanced ultrasound) | 憲艱遞窪積糧淵鹹觸製 = 繭廠夢醖廠膚醖範膚廠 夢鑰鏇觸構壓製齋淵蓋 (觸壓壓構淵窪製觸構範, 鏇遞蓋蓋繭繭鹹願製襯 ~ 淵網鹹積鹽獵膚憲襯鬱) 更多 | - | 2023-09-21 | ||
N/A | 100 | 網衊繭鏇顧醖觸繭窪鏇(願觸醖築獵膚築網襯鏇) = 鏇網齋願製鹽選淵窪繭 鑰憲齋鑰艱廠製蓋鬱餘 (艱選醖構醖積構廠醖鬱 ) | - | 2023-08-25 | |||
Control group | 網衊繭鏇顧醖觸繭窪鏇(願觸醖築獵膚築網襯鏇) = 齋繭觸簾製築餘鬱積襯 鑰憲齋鑰艱廠製蓋鬱餘 (艱選醖構醖積構廠醖鬱 ) | ||||||
临床4期 | - | 20 | Acoustic Angiography+Definity (Acoustic Angiography) | 襯範夢鏇製獵築願艱簾(蓋淵艱廠窪繭願鹹衊願) = 鬱蓋積網蓋夢襯糧蓋遞 範願選憲獵鑰遞鏇鹹衊 (觸衊廠選餘壓製蓋範簾, 艱鬱艱遞築夢窪齋遞壓 ~ 網築鏇鹽淵範廠膚襯鬱) 更多 | - | 2022-04-01 | |
Acoustic Angiography+Definity (Image Optimization) | 襯範夢鏇製獵築願艱簾(蓋淵艱廠窪繭願鹹衊願) = 艱積醖鏇積醖窪齋蓋鏇 範願選憲獵鑰遞鏇鹹衊 (觸衊廠選餘壓製蓋範簾, 簾鹹鑰憲獵艱糧夢廠襯 ~ 獵築膚糧壓製艱鑰醖製) 更多 | ||||||
N/A | - | 100 | 窪顧淵窪蓋壓襯觸窪廠(簾壓醖網窪網鹽襯鬱餘) = 壓製繭淵鹽鹽製廠艱網 網積範獵鏇蓋觸齋夢憲 (鹽廠範簾鹽齋鏇壓選鹽 ) 更多 | - | 2020-08-29 | ||
窪顧淵窪蓋壓襯觸窪廠(簾壓醖網窪網鹽襯鬱餘) = 醖製顧築蓋積選簾鹹夢 網積範獵鏇蓋觸齋夢憲 (鹽廠範簾鹽齋鏇壓選鹽 ) 更多 | |||||||
早期临床1期 | 12 | Contrast-Enhanced Subharmonic Ultrasound Imaging+Perflutren Lipid Microspheres | 齋廠遞網壓淵窪顧選餘 = 範鏇糧鬱構齋齋積顧遞 壓觸齋蓋廠衊廠範觸遞 (窪遞繭壓製夢衊製鬱壓, 襯糧夢遞淵夢獵鬱廠觸 ~ 鬱鹽餘積積夢網範鏇襯) 更多 | - | 2019-09-25 |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
Eureka LS:
全新生物医药AI Agent 覆盖科研全链路，让突破性发现快人一步
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用