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更新于：2025-12-24
Molnupiravir
莫诺拉韦
更新于：2025-12-24
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
首次获批日期 英国 (2021-11-14), |
最高研发阶段(中国)批准上市 |
特殊审评紧急使用授权 (美国)、紧急使用授权 (韩国)、附条件批准 (中国) |
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结构/序列
分子式C13H19N3O7 |
InChIKeyHTNPEHXGEKVIHG-QCNRFFRDSA-N |
CAS号2492423-29-5 |
关联
47
项与 莫诺拉韦 相关的临床试验NCT06551844
Adaptive Dengue Antiviral Platform Trial (ADAPT): a Phase 2 Randomized, Adaptive, Open Label Trial for Antiviral Screening in Patients With Early Symptomatic Dengue
This is a randomized, open-label adaptive platform trial aiming to screen the antiviral effectiveness of the experimental drug(s) in early dengue infection
* Primary objectives:
* To determine the antiviral effectiveness of the experimental drug(s) in early dengue infection
* To assess the safety and tolerability of the experimental drug(s) in dengue patients
* Secondary objective:
* To assess the effect of the experimental drug(s) in dengue patients on physiological, clinical and virological parameters
* Primary objectives:
* To determine the antiviral effectiveness of the experimental drug(s) in early dengue infection
* To assess the safety and tolerability of the experimental drug(s) in dengue patients
* Secondary objective:
* To assess the effect of the experimental drug(s) in dengue patients on physiological, clinical and virological parameters
开始日期2025-09-01 |
NCT06667700
A Phase 3, Randomized, Placebo-Controlled, Double-Blind Clinical Study to Evaluate the Efficacy and Safety of Molnupiravir (MK-4482) in Non-Hospitalized Adults With COVID-19 at High Risk for Disease Progression
Researchers are looking for other ways to prevent severe illness from COVID-19. COVID-19 is a virus that most often causes mild flu or cold-like symptoms. However, people with certain health conditions or other factors have a high risk (chance) of getting severely ill from COVID-19, which can require a hospital stay or lead to death. Some people who are high risk for severe illness may be unable to take certain treatments for COVID-19 because they are not available to them, or they take other medicines that may react with a treatment and cause an unwanted effect.
Molnupiravir (MK-4482) is a study medicine designed to stop the COVID-19 virus from copying itself in the body (multiplying). The goal of this study is to learn if molnupiravir prevents severe illness from COVID-19 more than placebo in people who are high risk.
Molnupiravir (MK-4482) is a study medicine designed to stop the COVID-19 virus from copying itself in the body (multiplying). The goal of this study is to learn if molnupiravir prevents severe illness from COVID-19 more than placebo in people who are high risk.
开始日期2024-12-02 |
申办/合作机构 |
NCT06488300
Assessment of Respiratory SYNcytial Virus antivirALs: A Phase 2 Multi-centre Adaptive Randomised Platform Trial For the Assessment of Antiviral Pharmacodynamics in aCute Symptomatic RSV Infection (ARSYNAL-FC)
This trial will use a previously validated platform, to quantitatively assess antiviral effects in low-risk patients with high viral burdens and uncomplicated Respiratory Syncytial Virus (RSV), to determine in-vivo antiviral activity. In this randomised, open-label, controlled, group sequential adaptive platform trial, we will assess and compare the performance of currently licensed interventions (including repurposed drugs) with activity against RSV, and those with potential activity demonstrated in pre-clinical and early clinical studies relative to each-other, and the control (no antiviral treatment).
ARSYNAL-FC study is funded by Wellcome Trust Grant ref: 226933/Z/23/Z through the COVID-19 Therapeutics Accelerator
ARSYNAL-FC study is funded by Wellcome Trust Grant ref: 226933/Z/23/Z through the COVID-19 Therapeutics Accelerator
开始日期2024-07-25 |
申办/合作机构 |
100 项与 莫诺拉韦 相关的临床结果
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100 项与 莫诺拉韦 相关的转化医学
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100 项与 莫诺拉韦 相关的专利（医药）
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1,021
项与 莫诺拉韦 相关的文献（医药）2026-01-01·VIROLOGY
Impact of baseline humoral immunity on treatment outcomes with molnupiravir in the MOVe-OUT randomized, controlled trial
Article
作者: Carmelitano, Patricia ; Paschke, Amanda ; Hilbert, David W ; Strizki, Julie M ; Johnson, Matthew G ; De Anda, Carisa S ; Zhang, Ying ; Wolf, Dominik J ; Brown, Michelle L
BACKGROUND:
In the large, randomized, placebo-controlled MOVe-OUT trial, molnupiravir reduced hospitalization/death in unvaccinated, high-risk adults with mild-to-moderate COVID-19. We investigated humoral immune responses and the impact of anti-SARS-CoV-2 antibodies in MOVe-OUT.
METHODS:
All participants prospectively underwent serum testing for total antibodies (combined IgA, IgG, and/or IgM) to the SARS-CoV-2 nucleocapsid protein and neutralizing antibodies to the spike protein. For participants with a positive baseline anti-nucleocapsid test, samples were retrospectively tested for subtype-specific IgM and IgG anti-nucleocapsid antibodies. Residual baseline samples from all participants were also retrospectively tested for anti-spike IgG antibodies. Clinical and virologic outcomes according to baseline antibody status were determined.
RESULTS:
Fewer participants in the molnupiravir (239/709, 33.7 %) than the placebo arm (259/699, 37.1 %) were positive for any baseline anti-SARS-CoV-2 antibody; anti-spike antibodies only, the specific pattern potentially indicating prior vaccination, were detected in 13.8 % molnupiravir-treated and 15.2 % placebo participants. Molnupiravir reduced the risk of hospitalization/death through day 29 in participants who were seronegative at baseline (molnupiravir 40/470 [8.5 %], placebo 64/440 [14.5 %], 95 % confidence interval for the risk difference: -10.3 % to -1.9 %). Post-baseline, most participants exhibited anti-SARS-CoV-2 antibodies by day 10; by day 29, anti-nucleocapsid antibodies were detected in 93.2 % of molnupiravir-treated and 94.9 % of placebo participants and neutralizing anti-SARS-CoV-2 antibodies in 80.8 % and 82.8 %, respectively.
CONCLUSION:
Anti-SARS-CoV-2 antibodies at baseline, more common with placebo, provided protection against poor clinical outcomes. Potentially undisclosed vaccination unlikely impacted the overall trial outcomes. Molnupiravir treatment did not significantly affect development of humoral immunity to SARS-CoV-2 infection.
CLINICALTRIALS:
gov: NCT04575597.
2025-12-31·Emerging Microbes & Infections
Effectiveness of nirmatrelvir/ritonavir and molnupiravir on post-COVID-19 outcomes among outpatients: a target trial emulation investigation
Article
作者: Li, Conglu ; Hui, David S. C. ; Mok, Chris Ka Pun ; Hung, Chi Tim ; Guo, Zihao ; Wang, Huwen ; Li, Kehang ; Boyer, Christopher ; Yam, Carrie Ho Kwan ; Jiang, Xiaoting ; Wei, Yuchen ; Chong, Ka Chun ; Lin, Guozhang ; Yang, Aimin ; Chow, Tsz Yu ; Yeoh, Eng Kiong ; Zhao, Shi ; Jia, Katherine Min ; Wang, Yawen
Limited studies compared the effectiveness of nirmatrelvir/ritonavir and molnupiravir against a control group on post-COVID-19 conditions. Our study examined the association of nirmatrelvir/ritonavir and molnupiravir with post-acute mortality and hospitalizations among outpatients using real-world outpatient records of COVID-19 designated clinics in Hong Kong. This is an observational study using a target trial emulation framework, involving nirmatrelvir-ritonavir versus no antiviral treatment (Trial 1) and molnupiravir versus no antiviral treatment (Trial 2). Outcomes included post-acute mortality, all-cause hospitalization, and hospitalization due to 13 selected sequelae. Relative effectiveness was assessed by comparing the cumulative incidence between two groups, reported as relative risk (RR), along with risk differences (RD) during day 0-30, 31-180, and 181-360. After screening, 140,477 and 96,030 patients were included in Trial 1 and 2, respectively. Compared with no treatment, nirmatrelvir/ritonavir-treated patients exhibited a significantly lower risk of post-acute mortality (31-180 days: RR, 0.71; 95% CI, 0.54-0.96; RD, 0.20%; 181-360 days: RR, 0.64; 95% CI, 0.50-0.82; RD, 0.32%) and all-cause hospitalization (31-180 days: RR, 0.82; 95% CI, 0.76-0.88; RD, 1.11%; 181-360 days: RR, 0.83; 95% CI, 0.78-0.89; RD, 1.18%). Patients receiving molnupiravir had a lower risk of 30-day mortality, but no significant beneficial effect was observed for the post-acute outcomes. In conclusion, this study demonstrated the effectiveness of nirmatrelvir/ritonavir in reducing post-COVID-19 outcomes among outpatients. While we observed the short-term effectiveness of molnupiravir in reducing mortality, no protective effect on long-term post-COVID-19 outcomes was observed.
2025-12-31·RENAL FAILURE
Safety and tolerability of molnupiravir and nirmatrelvir/ritonavir in patients with advanced chronic kidney disease and kidney failure; a cohort study
Article
作者: Ouyang, Tianqi ; Moreno, Daiana ; Sawtell, Rani ; Mejia, Sherley M. ; Sise, Meghan E. ; Strohbehn, Ian
Patients with advanced chronic kidney disease (CKD) and kidney failure were excluded from clinical trials that led to approval of molnupiravir and nirmatrelvir/ritonavir for COVID-19. Between November 2022 and February 2024 there were 100 patients with advanced CKD (N = 81) or kidney failure (N = 19) who received either molnupiravir (N = 40) or nirmatrelvir/ritonavir (N = 60) for COVID-19 within a large healthcare network. Ten (10%) patients were hospitalized within 30 days; 5 hospitalizations were COVID-19 related and 5 were unrelated to COVID-19. Adverse events documented in the electronic health record were uncommon and all were mild to moderate (grade 1 or 2). Despite use of numerous concomitant medications known to interact with nirmaltrelvir/ritonavir, we found no adverse events attributed to a drug-drug interaction. All patients survived >30 days and 3 (3%) died prior to 90 days. Molnupiravir and nirmatrelvir/ritonavir were safe and well tolerated in patients with advanced CKD and kidney failure.
688
项与 莫诺拉韦 相关的新闻（医药）2025-12-13
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截至12月13日15点59分，近期共有 516 本期刊发布了 1042 篇文章，其中糖尿病相关的文章共 423 篇，覆盖 36 个领域的内容。中国专家参与发表的文章有 133 篇。今日，影响因子最高的文章刊登在 Nature medicine (IF: 50.000) 期刊上。
今日头条
Headlines
01 Int J Biol Macromol IF: 08.500 自适应可注射普鲁兰糖/羧甲基壳聚糖水凝胶通过抗菌、促血管生成和免疫调节作用加速糖尿病伤口愈合
Xiao, Zhenyong, Zhao, Hu, Yu, Qiuyi, Luo, Hanwen, Liu, Yan, Liu, Ziying, etc.
糖尿病引起的慢性伤口，因其复杂的病理环境，如持续炎症、易发感染和血管生成障碍，一直是临床治疗中的巨大挑战。近日，一项发表在《International journal of biological macromolecules》上的研究，为这一难题带来了新的解决方案。由研究人员Xiao Zhenyong、Zhao Hu、Yu Qiuyi、Luo Hanwen、Liu Yan、Liu Ziying、Xie Xiangtao和Liu Bo共同完成的研究，成功开发出一种名为PCCCu的多功能自适应可注射水凝胶，该水凝胶在实验中展现出加速糖尿病伤口愈合的显著效果。
该研究的核心是一种创新的水凝胶材料。研究人员将氧化普鲁兰糖与羧甲基壳聚糖（CMCS)通过动态的希夫碱反应进行交联，构建了一个灵活的网络结构。在此基础上，他们进一步将具有抗炎活性的姜黄素和具有抗菌潜力的氧化铜纳米颗粒整合到网络中，最终形成了PCCCu水凝胶。这种设计使得水凝胶不仅具备可注射性，能够轻松填充和贴合不规则的伤口创面，还赋予了其结构上的稳定性，为伤口提供了理想的物理屏障和药物递送平台。
为了全面评估PCCCu水凝胶的效能，研究团队进行了一系列严谨的体外实验。结果显示，该水凝胶具有良好的生物相容性，其溶血率低于5%，表明其对血液细胞的安全性。在对抗细菌感染方面，PCCCu水凝胶表现突出，其抗菌率超过90%，为伤口免受感染提供了有力保障。此外，实验还证实该水凝胶具备强大的促血管生成能力，并能通过调节巨噬细胞极化来调控炎症反应，这恰恰针对了糖尿病伤口愈合过程中炎症失控和血管新生不足的核心问题。
研究的最终验证在糖尿病大鼠模型中进行。动物实验的结果令人鼓舞，应用了PCCCu水凝胶的糖尿病伤口，其愈合过程被显著加速。组织学分析进一步揭示了其作用的深层机制：水凝胶处理后的伤口，上皮化进程更快，新生肉芽组织更丰富，血管再生更为活跃，并且胶原纤维的排列也更趋有序和成熟。这些微观层面的改善，共同促成了宏观上伤口更快更好地闭合。
综上所述，这项研究开发的PCCCu自适应可注射水凝胶，通过其抗菌、促血管生成和免疫调节的多重协同作用，在实验模型中有效促进了糖尿病伤口的愈合。该成果为开发新型糖尿病伤口敷料提供了有价值的思路和实验依据。
本文由 丁克芳 编辑
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Int J Biol Macromol | Ahead of Print.
10.1016/j.ijbiomac.2025.149616
02 Diabetes Res Clin Pract IF: 07.400 动态血糖监测在临床实践中对使用胰岛素方案的2型糖尿病患者的效用：病例系列与专家意见
一项聚焦于动态血糖监测技术临床应用的最新综述与专家意见，为使用胰岛素治疗的2型糖尿病患者的精准管理提供了实用指引。这项工作的核心在于，针对亚洲地区相关临床指导相对缺乏的现状，通过结合真实病例与专家分析，旨在帮助临床医生更有效地利用这一技术。
该文章明确指出，对于依赖胰岛素的2型糖尿病患者，动态血糖监测能够提供传统指尖血糖检测难以获取的连续血糖信息，清晰揭示患者全天的血糖波动模式。这不仅有助于医生精细化调整胰岛素剂量和用药方案，还能为患者选择饮食、运动等生活方式提供直观依据，同时免去了频繁扎手指带来的痛苦与不便。
值得关注的是，文章特别区分了三种常见的临床场景进行深入探讨。首先是身体状况相对简单、没有其他严重合并症的患者；其次是同时伴有高血压、血脂异常等心血管疾病风险因素的患者；第三则是需要特别关注的老年糖尿病患者群体。针对每一类人群，动态血糖监测的应用重点和考量均有不同。
为了将理论转化为实践，文中精心展示了五个经过匿名处理的真实临床病例。这些案例均附有详细的动态葡萄糖图谱，生动演示了如何解读数据，并基于数据发现的问题来调整治疗策略，从而改善患者的血糖控制结局。这些来自临床一线的实例，为同行提供了极具参考价值的操作范本。
基于病例分析与现有文献依据，专家们系统阐述了动态血糖监测在上述不同患者群体中能够带来的多重获益。其价值不仅局限于优化降糖效果，更延伸到通过预防和及时处理低血糖事件来提升治疗安全性，并最终改善患者的治疗体验与长期生活质量。
综合所有讨论，文章的最终产出是一份包含十项要点的核心临床实践建议清单。这些建议旨在全方位指导临床工作者，更科学地运用动态血糖监测技术，以实现个体化的血糖控制目标，优化胰岛素治疗方案，增强患者对健康生活方式的执行力，最大程度降低低血糖风险，从而全面守护患者的健康与福祉。
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Diabetes Res Clin Pract | Ahead of Print.
10.1016/j.diabres.2025.113054
03 Drug delivery IF: 08.100 无针注射器与胰岛素笔在糖尿病管理中的有效性、安全性及以患者为中心的结局：一项全面荟萃分析
Wang, Jing, Chen, Xinhao, Ge, Zhili, Xia, Yingran, Tang, Zixiang, Sun, Zehao, etc.
一项近期发表于《Drug delivery》期刊的全面荟萃分析，为糖尿病患者的胰岛素注射方式提供了新的循证依据。该研究系统比较了无针注射器与传统胰岛素笔在治疗效果、安全性和患者感受方面的差异。
这项研究由Wang Jing, Chen Xinhao等多位研究者共同完成。为了获得可靠的结论，研究团队系统检索了截至2024年6月，发表在CNKI、Weipu、PubMed等多个主流中英文数据库中的相关随机对照试验。最终，共计22项符合标准的研究被纳入分析，这些研究共涉及2580名糖尿病患者，其中使用无针注射器与胰岛素笔的患者各占一半，均为1290名。
分析结果显示，在控制血糖的核心指标上，无针注射器展现出了一定优势。与使用胰岛素笔的患者相比，使用无针注射器的患者其糖化血红蛋白、空腹血糖以及餐后2小时血糖的下降程度更为显著。这表明，在改善血糖水平方面，无针注射器可能是一种更有效的给药工具。
在安全性方面，研究评估了局部和全身两种类型的风险。在注射局部，无针注射器相关的皮肤不良反应发生率更低。而在全身性风险方面，最为患者关注的低血糖事件，其发生率在两组之间并无统计学上的显著差异，提示两种注射方式的系统性安全风险可能相近。
除了客观的临床指标，研究还关注了患者的主观体验。分析发现，患者对无针注射器的接受度和满意度普遍高于传统的胰岛素笔。这提示，减少或避免针头使用可能从心理和使用感受层面改善患者的治疗体验。
然而，研究也指出了一些未观察到显著差异的领域。例如，在反映日内血糖波动的持续血糖监测相关指标上，两种注射方式并未体现出明显区别。研究者表示，这意味着无针注射器对血糖稳定性的长期影响，仍需更多研究来明确。
综合来看，这项荟萃分析表明，对于需要胰岛素治疗的糖尿病患者，无针注射器在改善部分关键血糖指标、减少局部皮肤反应以及提升患者治疗体验方面可能优于传统胰岛素笔。研究结果为临床选择个体化的胰岛素注射方式提供了参考，但研究者也强调，其长期疗效和安全性仍有待进一步验证。
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Drug delivery | Volume 32, Issue 1
10.1080/10717544.2025.2597906
04 Hepatobiliary Surg Nutr IF: 07.800 评估2型糖尿病中代谢功能障碍相关脂肪性肝病的风险：Fibrosis-4指数仍是可靠工具吗？
Yoneda, Masato, Kobayashi, Takashi, Iwaki, Michihiro, Wada, Naohiro, Nogami, Asako, Nakajima, Atsushi, etc.
近期发表于《Clinical and Molecular Hepatology》的一项重磅荟萃分析，对广泛应用于肝纤维化评估的FIB-4指数在2型糖尿病（T2DM）人群中的可靠性提出了重要质疑。该研究由Han等人完成，系统评估了FIB-4在鉴别T2DM合并代谢功能障碍相关脂肪性肝病（MASLD）患者晚期肝纤维化方面的诊断性能。
研究发现，当使用临床常用的FIB-4低阈值（1.3至1.67）进行筛查时，其排除晚期纤维化的能力——即阴性预测值（NPV）仅为0.82。这一数值低于通常认为足以确保临床信心的0.90门槛。这意味着，即使在FIB-4评分被认为是“低风险”的T2DM患者中，仍有相当一部分人可能实际存在需要关注的晚期肝纤维化，从而面临漏诊风险。
研究进一步揭示，问题在晚期纤维化患病率较高的人群中尤为突出。众所周知，T2DM患者是肝纤维化快速进展的高危群体，其晚期纤维化的患病率可能显著高于普通人群。该分析模拟显示，当患病率上升到30%至50%的范围内时，FIB-4的阴性预测值会急剧下降至0.70以下。这一数据强烈提示，在当前指南推荐的使用FIB-4作为初筛工具的策略下，大量本应被识别出来的高风险T2DM患者可能被错误地归类，从而错失早期干预和专科转诊的时机。
另一方面，当采用较高的FIB-4阈值（2.67至3.25）时，虽然确诊能力很强——特异性高达0.92，阳性预测值达到0.70，但其发现疾病的能力却非常有限，灵敏度低至0.33。这表明高阈值不适用于广泛的筛查目的，因为它会漏掉超过三分之二的晚期纤维化病例。
该荟萃分析共纳入了12项研究，涉及全球范围内5624名经肝脏活检确诊的T2DM合并MASLD患者，确保了结论的广泛代表性和可靠性。分析还指出，患者年龄、更晚期纤维化的比例等因素可能进一步影响FIB-4的准确性，强调了对这一人群需要更个体化的评估方法。
这些发现对广大初级保健医生、内分泌科医生及肝病科医生具有直接的实践意义。它警示临床工作者，对于T2DM患者，单纯依赖FIB-4指数可能不足以安全地排除严重的肝脏疾病。研究团队在文中强调，当前的临床管理路径可能需要调整，例如考虑对T2DM患者采用更低的FIB-4阈值来触发进一步检查，或者更频繁地进行FIB-4评估。
同时，研究支持了当前国际指南中已提及的补充策略的重要性，即在FIB-4初筛后，对于不确定或高危的患者，应积极采用第二线评估工具。这包括诸如振动控制瞬时弹性成像（VCTE）、血清学标志物如增强肝纤维化（ELF）检测，或在亚洲地区应用日益广泛的Mac-2结合蛋白糖基化异构体（M2BPGi）等。开发融合了T2DM特异性风险因素（如血糖控制情况）的新型纤维化评分系统，也被认为是未来的重要方向。
随着全球T2DM和MASLD患病率的持续攀升，如何在资源有限的情况下精准识别出肝病进展风险最高的个体，已成为公共卫生和临床医学面临的关键挑战。这项研究为优化这一高风险人群的肝纤维化筛查策略提供了关键的循证依据，呼吁学界和临床界共同审视并完善现有实践。
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Hepatobiliary Surg Nutr | Volume 14, Issue 6
10.21037/hbsn-2025-439
05 Diabetology & metabolic syndrome IF: 03.900 代谢控制对2型糖尿病合并慢性多支冠状动脉疾病患者心血管结局的影响：一项队列研究
Andrade, Vitor Coutinho, Rezende, Paulo Cury, Hueb, Whady, Garcia, Rosa Maria Rahmi, de Assis, Arthur Cicupira Rodrigues, da Silva, Marcela Francisca, etc.
一项发表在Diabetology & metabolic syndrome上的研究，深入探讨了代谢控制水平对于2型糖尿病合并慢性多支冠状动脉疾病患者长期心血管健康的关键影响。该研究由Andrade, Vitor Coutinho、Rezende, Paulo Cury、Hueb, Whady等研究者共同完成。
研究团队回顾性分析了自1995年至2010年间纳入的884名患者数据，最终筛选出718名符合条件的研究对象进行深入分析。这些患者平均年龄为61岁，其中女性占比35.3%。研究的核心在于评估低密度脂蛋白胆固醇、糖化血红蛋白和甘油三酯这三项关键代谢指标的控制情况与心血管结局之间的关联。根据指标达标数量，患者被分为四个组别进行长期随访，平均随访时间长达8年。
分析结果显示，患者代谢控制情况分布如下：27.8%的患者三项指标均控制在目标范围内，36.2%的患者有两项达标，24.3%的患者仅一项达标，而11.7%的患者则三项指标均未达标。研究团队在调整了年龄、性别、吸烟状况、射血分数、病变血管数量及初始治疗方案等多种潜在混杂因素后，进行了严谨的统计分析。
研究发现了一个清晰的趋势：代谢指标控制得越差，主要不良心血管事件的发生风险就越高，呈现出显著的“剂量-反应”关系。具体而言，与三项指标全部达标的患者群体相比，那些没有任何一项指标达标的患者，在长期随访中遭遇全因死亡、心肌梗死、卒中或非计划性血运重建等复合终点的风险增加了近三倍，其风险比高达2.87。
这项研究通过长期的队列数据表明，对于已经确诊为稳定型冠状动脉疾病和2型糖尿病的患者而言，持续、综合地管理好血脂和血糖等代谢指标，对于降低未来发生严重心血管事件的风险具有明确的临床重要性。研究结果强调了在这一高危人群中实施全面风险管理策略的必要性。
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Diabetology & metabolic syndrome | Ahead of Print.
10.1186/s13098-025-02027-6
中国发表（133）
China
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BMJ open IF: 02.300Volume 15, Issue 12No.05Developing policy on sugar-sweetened beverages for children and adolescents in China: a qualitative study of stakeholder views and perceptions制定中国儿童及青少年含糖饮料政策的探索：一项关于利益相关者观点与认知的定性研究DOI: 10.1136/bmjopen-2025-098746
Phytomedicine IF: 08.300Ahead of Print.No.06Shenling Baizhu Powder attenuates cognitive impairment via the gut-brain axis in diet-induced obese mice参苓白术散通过肠-脑轴改善饮食诱导肥胖小鼠的认知障碍DOI: 10.1016/j.phymed.2025.157654
Journal of applied toxicology IF: 02.800Ahead of Print.No.07Atypical Antipsychotics-Induced Glucose and Lipid Metabolism Disorders and Therapeutic Intervention非典型抗精神病药所致糖脂代谢紊乱及治疗干预DOI: 10.1002/jat.70036
International immunopharmacology IF: 04.700Ahead of Print.No.08GLP-1 receptor agonist liraglutide facilitates rotator cuff healing by reducing tendon cell inflammation and endoplasmic reticulum stress through the GLP-1R-AMPK/SIRT1 pathwayGLP-1受体激动剂利拉鲁肽通过GLP-1R-AMPK/SIRT1通路减轻肌腱细胞炎症和内质网应激促进肩袖愈合DOI: 10.1016/j.intimp.2025.116010
Eur J Med Res IF: 03.400Ahead of Print.No.09Combined triglyceride-glucose index and systemic inflammation response index are associated with coronary artery stenosis severity in acute coronary syndrome: a retrospective cohort study联合甘油三酯-葡萄糖指数与全身炎症反应指数与急性冠脉综合征冠脉狭窄严重程度相关：一项回顾性队列研究DOI: 10.1186/s40001-025-03650-9
Free radical biology & medicine IF: 08.200Ahead of Print.No.10Insulin-activated β-cell-liver axis protects against acetaminophen-induced acute liver injury by suppressing oxidative stress and purine catabolism胰岛素激活的β细胞-肝脏轴保护对乙酰氨基酚所致急性肝损伤的机制：抑制氧化应激与嘌呤分解代谢DOI: 10.1016/j.freeradbiomed.2025.12.009
Advanced science IF: 14.100Ahead of Print.No.11Colorectal Cancer Cell's Weapon: RNF32 Engages SPP1(+) Macrophages to Foster Liver Metastasis, Targeted by Indole-3-Acetic Acid结直肠癌细胞的武器：RNF32募集SPP1阳性巨噬细胞促进肝转移，吲哚-3-乙酸可靶向干预DOI: 10.1002/advs.202519735
J Genet Eng Biotechnol IF: 02.800Volume 23, Issue 4No.12Bioinformatics and experimental validation of MAPK pathway activation in diabetic kidney disease induced by glucose variability血糖波动诱导的糖尿病肾病中MAPK通路激活的生物信息学与实验验证DOI: 10.1016/j.jgeb.2025.100598
Biochim Biophys Acta Mol Basis Dis IF: 04.200Ahead of Print.No.13Duration-dependent alterations of lipid profiles and microvascular complications in GCK-MODYGCK-MODY中脂质谱与微血管并发症的时长依赖性改变DOI: 10.1016/j.bbadis.2025.168137
Stem cell research & therapy IF: 07.300Ahead of Print.No.14Dual-target hUCMSCs/EVs therapy for autism spectrum disorder: remodeling gut microbiota and modulating neuroimmune crosstalk in a valproic acid-induced C57BL/6 mice model双靶向hUCMSCs/EVs疗法治疗自闭症谱系障碍：在丙戊酸诱导的C57BL/6小鼠模型中重塑肠道微生物群及调控神经免疫交互DOI: 10.1186/s13287-025-04829-x
BMC urology IF: 01.900Ahead of Print.No.15Association between red cell distribution width-to-albumin ratio and risk of diabetic kidney disease: a cross-sectional NHANES study红细胞分布宽度与白蛋白比值与糖尿病肾病风险的相关性：一项基于NHANES的横断面研究DOI: 10.1186/s12894-025-02009-w
Nature communications IF: 15.700Ahead of Print.No.16Genetic profiling of the circulating proteome in common diseases suggests causal proteins and improves risk prediction常见疾病中循环蛋白质组的遗传图谱分析提示致病蛋白并提升风险预测效能DOI: 10.1038/s41467-025-67238-x
Pediatric research IF: 03.100Ahead of Print.No.17Sleep heterogeneity in adolescents with type 1 diabetes: correlations with glycemic control, stigma, and resilience青少年1型糖尿病患者的睡眠异质性：与血糖控制、病耻感及心理韧性的相关性研究DOI: 10.1038/s41390-025-04644-3
Nature communications IF: 15.700Ahead of Print.No.18Hyperglycemia exacerbates osteoarthritis by impairing macrophage efferocytosis through modulation of CD11b lactylation高血糖通过CD11b乳酸化修饰损伤巨噬细胞胞葬作用加剧骨关节炎DOI: 10.1038/s41467-025-67473-2
Obesity reviews IF: 07.400Ahead of Print.No.19Circulating Proteins Link Obesity With Cardiac Remodeling: Insights From Mendelian Randomization循环蛋白连接肥胖与心脏重塑：孟德尔随机化研究的启示DOI: 10.1111/obr.70059
Nano letters IF: 09.100Ahead of Print.No.20Programming Molecular Switches within Capacitive PEDOT:DNA Hydrogels for Deciphering Pathophysiological Microenvironment Dynamics in Diabetic Wound在电容式PEDOT:DNA水凝胶中编程分子开关用于解码糖尿病伤口病理生理微环境动态DOI: 10.1021/acs.nanolett.5c05009
J Neurointerv Surg IF: 04.300Ahead of Print.No.21Safety and efficacy of sequential intra-arterial and intravenous administration of tirofiban during the periprocedural period of stenting in perforator-rich intracranial arteries穿支丰富颅内动脉支架围手术期序贯动脉内与静脉内应用替罗非班的安全性与有效性DOI: 10.1136/jnis-2025-024471
Int J Biol Macromol IF: 08.500Ahead of Print.No.22Adaptive injectable pullulan/carboxymethyl chitosan hydrogel accelerates diabetic wound healing through antibacterial, angiogenic, and immunomodulatory effects自适应可注射普鲁兰糖/羧甲基壳聚糖水凝胶通过抗菌、促血管生成和免疫调节作用加速糖尿病伤口愈合DOI: 10.1016/j.ijbiomac.2025.149616
European journal of pharmacology IF: 04.700Ahead of Print.No.23Metformin's Hidden Power: Unveiling Its Role in Melanoma Suppression Through endo-lysosome pH and Autophagy Regulation二甲双胍的隐藏力量：通过内溶酶体pH与自噬调控揭示其在黑色素瘤抑制中的作用DOI: 10.1016/j.ejphar.2025.178438
Fitoterapia IF: 02.600Ahead of Print.No.24Amide alkaloids from the fruits of Piper longum L. and their bioactivities长果胡椒果实中酰胺生物碱的分离鉴定及其生物活性研究DOI: 10.1016/j.fitote.2025.107024
Fitoterapia IF: 02.600Ahead of Print.No.25Integrating mouse oral trial, LC-HRMS-based untargeted metabolomics and network pharmacology for screening bioactive components of Astragalus membranaceus curing type-II diabetes mellitus (T2DM)整合小鼠口服试验、LC-HRMS非靶向代谢组学与网络药理学技术筛选黄芪治疗2型糖尿病的生物活性成分DOI: 10.1016/j.fitote.2025.107033
Arch Biochem Biophys IF: 03.000Ahead of Print.No.26LncRNA SNHG6 Attenuates Ferroptosis in High Glucose-treated Renal Tubular Epithelial Cells by Stabilizing YY1 to Activate the PI3K/AKT/GSK-3β PathwayLncRNA SNHG6通过稳定YY1激活PI3K/AKT/GSK-3β通路减轻高糖处理的肾小管上皮细胞铁死亡DOI: 10.1016/j.abb.2025.110702
Phytomedicine IF: 08.300Ahead of Print.No.27Safranal accelerates diabetic wound healing by suppressing ferroptosis through modulation of transcription factor Forkhead Box O3藏花醛通过调节转录因子Forkhead Box O3抑制铁死亡从而加速糖尿病伤口愈合DOI: 10.1016/j.phymed.2025.157675
Phytomedicine IF: 08.300Ahead of Print.No.28Corylin ameliorates diabetic osteoporosis by inhibiting inflammation via targeting RAG1Corylin通过靶向RAG1抑制炎症改善糖尿病骨质疏松症DOI: 10.1016/j.phymed.2025.157671
Phytomedicine IF: 08.300Ahead of Print.No.29Swietenine attenuates renal tubular injury by activating mitophagy in diabetic nephropathySwietenine通过激活线粒体自噬减轻糖尿病肾病的肾小管损伤DOI: 10.1016/j.phymed.2025.157668
Biomedicine & pharmacotherapy IF: 07.500Ahead of Print.No.30Chiglitazar, a PPAR pan-agonist: Impacts on type 2 diabetes mellitus and multi-system metabolic regulation - A reviewPPAR泛激动剂Chiglitazar：对2型糖尿病及多系统代谢调节的影响——一篇综述DOI: 10.1016/j.biopha.2025.118850
Cell reports IF: 06.900Ahead of Print.No.31Tracing the origin of testosterone-producing Leydig cells during pubertal development, homeostasis, and regeneration追踪睾酮生成Leydig细胞在青春期发育、稳态和再生过程中的起源DOI: 10.1016/j.celrep.2025.116674
J Diabetes Investig IF: 03.000Ahead of Print.No.32FGF11 regulated by CTBP1-AS2/miR-520a-5p/miR-432-5p axis inhibits the progression and angiogenesis in high glucose-treated human microvascular endothelial cellsCTBP1-AS2/miR-520a-5p/miR-432-5p轴调控的FGF11抑制高糖处理的人微血管内皮细胞的进展与血管生成DOI: 10.1111/jdi.13990
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Skin research and technology IF: 03.200Volume 31, Issue 12No.35Clinical Characteristics of Plantar Warts and Association With BMI: A Retrospective Case Series Study跖疣的临床特征及其与BMI的关联：一项回顾性病例系列研究DOI: 10.1111/srt.70303
Gut microbes IF: 11.000Volume 17, Issue 1No.36Helicobacter pylori infection aggravates hepatic steatosis by lactylation-driven WTAP-mediated m(6)A modification幽门螺杆菌感染通过乳酸化驱动的WTAP介导的m6A修饰加重肝脏脂肪变性DOI: 10.1080/19490976.2025.2599543
Gynecological endocrinology IF: 01.700Volume 41, Issue 1No.37A review of immunometabolic crosstalk in PCOS-related pregnancy loss: mechanisms and emerging therapeutic strategiesPCOS相关流产中免疫代谢串扰的综述：机制与新兴治疗策略DOI: 10.1080/09513590.2025.2600160
Int J Clin Oncol IF: 02.800Ahead of Print.No.38Advances in endometrial cancer screening: a comprehensive review of current methods and emerging technologies子宫内膜癌筛查进展：现有方法与新兴技术的全面综述DOI: 10.1007/s10147-025-02941-9
Breast Cancer Res Treat IF: 03.000Volume 215, Issue 1No.39Risk factors for postoperative bleeding following breast cancer surgery: a systematic review and meta-analysis乳腺癌术后出血的风险因素：一项系统评价与荟萃分析DOI: 10.1007/s10549-025-07849-6
Molecular biology reports IF: 02.800Volume 53, Issue 1No.40Exploration of common therapeutic targets for diabetic nephropathy and diabetic foot ulcers by integrated bioinformatics analysis and experimental validation整合生物信息学分析与实验验证探索糖尿病肾病和糖尿病足溃疡的共同治疗靶点DOI: 10.1007/s11033-025-11350-0
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The FASEB journal : IF: 04.200Volume 39, Issue 24No.43Bruceine A Ameliorates Osteoporosis Through Suppression of RACK1-Mediated OsteoclastogenesisBruceine A通过抑制RACK1介导的破骨细胞生成改善骨质疏松DOI: 10.1096/fj.202502953R
JMIR serious games IF: 04.100Volume 13, Issue No.44Development and Evaluation of a Monocular Camera-Based Mobile Exergame for at-Home Intervention in Individuals at High Risk of Type 2 Diabetes: Randomized Controlled Trial开发与评估基于单目摄像头的移动体感游戏用于2型糖尿病高风险人群的家庭干预：一项随机对照试验DOI: 10.2196/75823
Journal of materials chemistry IF: 05.700Ahead of Print.No.45A multifunctional composite hydrogel with natural polymer silk fibroin and gelatin for promoting chronic wound healing一种用于促进慢性伤口愈合的含天然聚合物丝素蛋白和明胶的多功能复合水凝胶DOI: 10.1039/d5tb02034d
Endocrine connections IF: 02.800Ahead of Print.No.46Real-world Pharmacovigilance Study of Drug-induced Diabetes Insipidus from the FAERS Database基于FAERS数据库的药物性尿崩症真实世界药物警戒研究DOI: 10.1530/EC-25-0734
Journal of global health IF: 04.300Volume 15, Issue No.47Longitudinal insights into comorbidity patterns and burden among middle-aged and older adults with diabetes in China: a nine-year cohort study using CHARLS中国中老年糖尿病患者合并症模式与负担的纵向洞察：一项基于CHARLS的九年队列研究DOI: 10.7189/jogh.15.04353
Journal of Alzheimer's disease IF: 03.100Ahead of Print.No.48Hsa_circ_0015335 as a potential biomarker for cognitive decline in type 2 diabetes mellitusHsa_circ_0015335：一个潜在的2型糖尿病认知功能下降生物标志物DOI: 10.1177/13872877251405447
Drug delivery IF: 08.100Volume 32, Issue 1No.49Efficacy, safety, and patient-centered outcomes of needle-free injectors versus insulin pens in diabetes management: a comprehensive meta-analysis无针注射器与胰岛素笔在糖尿病管理中的有效性、安全性及以患者为中心的结局：一项全面荟萃分析DOI: 10.1080/10717544.2025.2597906
The Journal of headache and pain IF: 07.900Volume 26, Issue 1No.50L3MBTL2 as a novel therapeutic target for trigeminal neuralgia: evidence from integrated TWAS, multi-tissue MR, and experimental validationL3MBTL2作为三叉神经痛的新治疗靶点：来自TWAS、多组织MR及实验验证的证据DOI: 10.1186/s10194-025-02218-6
Journal of pain research IF: 02.500Volume 18, Issue No.51Causal Relationships Between Neuropathic Pain and Alzheimer's Disease: A Multi-Omics Mendelian Randomization Study with Exploratory Evidence of a Potential Protective Role of Diabetic Neuropathy神经病理性疼痛与阿尔茨海默病之间的因果关系：一项结合多组学孟德尔随机化与糖尿病神经病变潜在保护作用的探索性证据研究DOI: 10.2147/JPR.S554433
Frontiers in public health IF: 03.400Volume 13, Issue No.52Multimorbidity patterns and cognitive frailty in adults aged over 50 years: China perspective中国50岁以上成年人的多重慢病模式与认知衰弱DOI: 10.3389/fpubh.2025.1701955
Future medicinal chemistry IF: 03.400Ahead of Print.No.53Small molecule inhibitors of HG-induced VEC ferroptosis: synthetic advances and therapeutic applications高血糖诱导的血管内皮细胞铁死亡的小分子抑制剂：合成进展与治疗应用DOI: 10.1080/17568919.2025.2602422
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.54Accurate screening of patients with diabetes based on physical examination: pancreas imaging features from chest CT and laboratory data基于体检的糖尿病患者精准筛查：胸部CT胰腺影像特征与实验室数据DOI: 10.3389/fendo.2025.1698247
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.55Prediction model for cognitive impairment in maintenance hemodialysis patients: the role of diabetes维持性血液透析患者认知功能损害的预测模型：糖尿病的作用DOI: 10.3389/fendo.2025.1594605
Risk Manag Healthc Policy IF: 02.000Volume 18, Issue No.56Analysis of Risk Factors of Postoperative Dry Eye in Cataract Patients Based on Lens Nucleus Hardness Grading基于晶状体核硬度分级的白内障患者术后干眼危险因素分析DOI: 10.2147/RMHP.S565376
Frontiers in immunology IF: 05.900Volume 16, Issue No.57Tumor-associated Tn and STn antigens: from molecular mechanism to precision diagnosis and treatment肿瘤相关Tn与STn抗原：从分子机制到精准诊疗DOI: 10.3389/fimmu.2025.1660852
Frontiers in nutrition IF: 05.100Volume 12, Issue No.58Comprehensive assessment of dietary micronutrient profiles and their effects on hemoglobin levels and anemia: provincial nutrition and health monitoring膳食微量营养素谱及其对血红蛋白水平与贫血影响的综合评估：省级营养与健康监测DOI: 10.3389/fnut.2025.1638705
Frontiers in nutrition IF: 05.100Volume 12, Issue No.59Association between geriatric nutritional risk index and fecal incontinence in individuals with stroke: mediating roles of systemic immune inflammation index and oxidative balance scores老年营养风险指数与卒中患者大便失禁的关联：系统免疫炎症指数和氧化平衡评分的中介作用DOI: 10.3389/fnut.2025.1692314
ACS Appl Mater Interfaces IF: 08.200Ahead of Print.No.60Mitochondrial-Targeting Drug-Loaded Nanoparticles Reprogram Macrophage Metabolism via ROS/NO Co-elimination for Diabetic Wound Healing线粒体靶向载药纳米颗粒通过ROS/NO共消除重编程巨噬细胞代谢促进糖尿病伤口愈合DOI: 10.1021/acsami.5c19664
ACS nano IF: 16.000Ahead of Print.No.61Anchoring Sn-Containing High-Entropy Alloy PtFeCoNiCuSn on SnO(2) for Improving Acetone Detection Ability将含锡高熵合金PtFeCoNiCuSn锚定在SnO2上以提升丙酮检测能力DOI: 10.1021/acsnano.5c15097
ACS sensors IF: 09.100Ahead of Print.No.62An Ant-Nest-Structured Wearable Sensor with pH Calibration for Reliable Monitoring of Sweat Glucose一种集成pH校准的蚁巢结构可穿戴传感器用于汗液葡萄糖可靠监测DOI: 10.1021/acssensors.5c03084
Zhong Nan Da Xue Xue Bao Yi Xue BanVolume 50, Issue 8No.63[Latent profile types and influencing factors of medication adherence mechanisms among rural older adults with multiple chronic conditions]农村多重慢病老年人用药依从性机制的潜在剖面类型及影响因素研究DOI: 10.11817/j.issn.1672-7347.2025.250141
Molecular Medicine Reports IF: 03.500Volume 33, Issue 2No.64Influence and treatment of insulin receptor substrate/PI3K/Akt‑mediated insulin resistance in diabetes mellitus (Review)胰岛素受体底物/PI3K/Akt介导的胰岛素抵抗在糖尿病中的影响与治疗DOI: 10.3892/mmr.2025.13773
Biomedical reports IF: 01.900Volume 24, Issue 2No.65ERp46 mitigates lipotoxic ER stress to preserve GLUT2 expression and insulin secretion in β-cellsERp46缓解脂毒性内质网应激以维持β细胞中GLUT2的表达和胰岛素分泌DOI: 10.3892/br.2025.2095
Ecology and evolution IF: 02.300Volume 15, Issue 12No.66Brain Transcriptomics Reveals Molecular Mechanisms of Cave Adaptation in Triplophysa Loaches脑转录组学揭示高原鳅洞穴适应的分子机制DOI: 10.1002/ece3.72652
J Am Chem Soc IF: 15.600Ahead of Print.No.67Small-Molecule Fe(3+)-Based Magnetic Resonance Imaging Probe Enables Noninvasive Imaging of Pancreatic Zn(2+) and β-Cell Function In Vivo基于小分子Fe(3+)的磁共振成像探针实现胰腺Zn(2+)及β细胞功能的体内无创成像DOI: 10.1021/jacs.5c17216
FCVM IF: 02.900Volume 12, Issue No.68Combined effects of insulin resistance and altitude of residence on 10-year risk of atherosclerotic cardiovascular disease胰岛素抵抗与居住海拔对动脉粥样硬化性心血管疾病10年风险的联合影响DOI: 10.3389/fcvm.2025.1656537
Food science & nutrition IF: 03.800Volume 13, Issue 12No.69Takeaway Food Consumption, Dietary Inflammatory Index, and Cardiometabolic Risk Factors in US Adults: Findings From NHANES (2009-2018)美国成年人外卖食品摄入、膳食炎症指数与心脏代谢风险因素：来自NHANES (2009-2018)的发现DOI: 10.1002/fsn3.71316
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.70Comparative analysis of the therapeutic effect of antibiotic bone cement on Wagner grade 3 or 4 diabetic foot ulcer in heel and non-heel areas: a retrospective cohort study抗生素骨水泥治疗足跟与非足跟区Wagner 3或4级糖尿病足溃疡的疗效比较：一项回顾性队列研究DOI: 10.3389/fendo.2025.1662731
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.71Transcriptomic profiling of diabetic retinopathy: insights into RPL11 and bisphenol A糖尿病视网膜病变的转录组学分析：聚焦RPL11与双酚ADOI: 10.3389/fendo.2025.1705233
Int J Nanomedicine IF: 06.500Volume 20, Issue No.72Mesenchymal Stem Cell-Derived Exosomes for Ocular Diseases: Therapeutic Mechanisms and Clinical Perspectives间充质干细胞来源的外泌体在眼部疾病中的应用：治疗机制与临床前景DOI: 10.2147/IJN.S555771
Exp Ther Med IF: 02.300Volume 31, Issue 2No.73Outcomes of anti-VEGF therapy compared with conventional interventions in diabetic retinopathy management抗血管内皮生长因子疗法与传统干预在糖尿病视网膜病变管理中的疗效对比DOI: 10.3892/etm.2025.13028
Organic letters IF: 05.000Ahead of Print.No.74NiCl(2)/Hdipm-Catalyzed 2-OH-Selective Alkylation of Glycoside trans-DiolsNiCl₂/Hdipm催化的糖苷反式二醇2-OH选择性烷基化DOI: 10.1021/acs.orglett.5c04886
Exp Ther Med IF: 02.300Volume 31, Issue 2No.75The influence of fetal sex on preterm birth risk in gestational diabetes mellitus: A retrospective cohort study胎儿性别对妊娠期糖尿病孕妇早产风险的影响：一项回顾性队列研究DOI: 10.3892/etm.2025.13034
NeuroprotectionVolume 3, Issue 1No.76Advancing neuroprotection and atherosclerosis prevention through familial hypercholesterolemia management: Analyzing comorbidity burden with stroke, coronary heart disease, hypertension, and diabetes通过管理家族性高胆固醇血症推动神经保护与动脉粥样硬化预防：分析其与卒中、冠心病、高血压和糖尿病的合并症负担DOI: 10.1002/nep3.72
Frontiers in physiology IF: 03.400Volume 16, Issue No.77Association between body mass index at different levels and risk of gastroesophageal reflux disease: a systematic review with dose-response meta-analysis不同水平的体重指数与胃食管反流病风险之间的关联：一项采用剂量反应Meta分析的系统评价DOI: 10.3389/fphys.2025.1675457
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.78Combination metformin and liraglutide in PCOS: clinical efficacy in women and preclinical insights from gut microbiome modulation in rats二甲双胍联合利拉鲁肽治疗PCOS：在女性中的临床有效性及其通过调节肠道微生物组获得的临床前洞见DOI: 10.3389/fendo.2025.1599879
Hepatobiliary Surg Nutr IF: 07.800Volume 14, Issue 6No.79From NAFPD to MAFPD: a literature review of implications of a nomenclature change从NAFPD到MAFPD：命名变更影响的文献综述DOI: 10.21037/hbsn-24-284
Frontiers in nutrition IF: 05.100Volume 12, Issue No.80Dietary patterns and obesity are associated with type 2 diabetes risk in elderly Chinese men: a machine learning approach饮食模式与肥胖和中国老年男性2型糖尿病风险相关：一项机器学习方法研究DOI: 10.3389/fnut.2025.1705683
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.81Association between vascular aging and cardiovascular-kidney-metabolic syndrome血管老化与心血管-肾脏-代谢综合征（CKM）的关联DOI: 10.3389/fendo.2025.1665836
Experimental Eye Research IF: 02.700Ahead of Print.No.82Canagliflozin inhibits NLRP3 Inflammasome activation to protect the Retinal Neurovascular Unit in a Mouse Retinal Vein Occlusion Model卡格列净通过抑制NLRP3炎症小体活化保护小鼠视网膜静脉阻塞模型中的视网膜神经血管单元DOI: 10.1016/j.exer.2025.110803
BMC geriatrics IF: 03.800Ahead of Print.No.83eHealth literacy mediates self-advocacy and self-management in older adults with diabetes电子健康素养在老年糖尿病患者自我倡导与自我管理中的中介作用DOI: 10.1186/s12877-025-06859-9
Hereditas : IF: 02.500Ahead of Print.No.84CD248, targeted by veratramine and neobavaisoflavone, mediates pathological changes of renal tubular epithelial cells induced by high glucoseCD248介导高糖诱导的肾小管上皮细胞病理变化，是黎芦胺和新巴伐异黄酮的作用靶点DOI: 10.1186/s41065-025-00624-z
Stem cell research & therapy IF: 07.300Ahead of Print.No.85Mesenchymal stem cell-derived extracellular vesicles for disease therapy by regulating ferroptosis: focus on diabetes mellitus and diabetic complications靶向铁死亡：间充质干细胞来源的细胞外囊泡的疾病治疗潜力——聚焦糖尿病及其并发症DOI: 10.1186/s13287-025-04852-y
Eur J Med Res IF: 03.400Ahead of Print.No.86Risk factors associated with bone cement leakage following percutaneous kyphoplasty: a retrospective analysis经皮椎体后凸成形术后骨水泥渗漏的相关风险因素：一项回顾性分析DOI: 10.1186/s40001-025-03608-x
Eur J Med Res IF: 03.400Ahead of Print.No.87A predictive nomogram for hemorrhage risk following endoscopic submucosal dissection of gastrointestinal tumors: a retrospective cohort study预测胃肠道肿瘤内镜黏膜下剥离术后出血风险的列线图模型：一项回顾性队列研究DOI: 10.1186/s40001-025-03599-9
Genome medicine IF: 11.200Ahead of Print.No.88Transcriptome-wide association study revealed novel causal genes of renal-biopsy proven diabetic nephropathy全转录组关联研究揭示肾活检确诊的糖尿病肾病新型致病基因DOI: 10.1186/s13073-025-01590-x
BMC ophthalmology IF: 01.700Ahead of Print.No.89Effects of blood pressure and blood glucose levels on foveal avascular zone area血压与血糖水平对黄斑无血管区面积的影响DOI: 10.1186/s12886-025-04534-6
BMC Cardiovascular Disorders IF: 02.300Ahead of Print.No.90Independent risk factors of hypertension in patients with chronic heart failure: insights from univariate and multivariate analyses慢性心力衰竭患者高血压的独立危险因素：基于单因素与多因素分析的启示DOI: 10.1186/s12872-025-05408-x
Scientific reports IF: 03.900Ahead of Print.No.91Long-term real-world performance of the Bayer Contour TS point-of-care testing glucose meters拜安捷血糖仪长期真实世界性能评估DOI: 10.1038/s41598-025-30850-4
Nature communications IF: 15.700Volume 16, Issue 1No.92Artificial intelligence-driven metabolomics of retinal nerve fibre layer to profile risks of mortality and cardiometabolic diseases人工智能驱动的视网膜神经纤维层代谢组学解析死亡与心脏代谢疾病风险DOI: 10.1038/s41467-025-66979-z
Food chemistry IF: 09.800Ahead of Print.No.93Synergistic effects of endogenous protein components and starch molecular structure on physicochemical, rheological and digestive properties in rice内源性蛋白组分与淀粉分子结构的协同作用对水稻理化、流变及消化特性的影响DOI: 10.1016/j.foodchem.2025.147443
Phytomedicine IF: 08.300Ahead of Print.No.94Multi-level intervention of Tangluoning on mitochondrial thioredoxin deficiency in Schwann cells ameliorates diabetic peripheral neuropathy汤剂Tangluoning对雪旺细胞线粒体硫氧还蛋白缺乏的多层次干预改善糖尿病周围神经病变DOI: 10.1016/j.phymed.2025.157656
Biochemical pharmacology IF: 05.600Ahead of Print.No.95RIPK3 deficiency ameliorates diabetic sarcopenia through proteostasis regulation by suppressing inflammatory signaling and cellular stress pathwaysRIPK3缺乏通过抑制炎症信号和细胞应激通路调节蛋白质稳态改善糖尿病肌肉减少症DOI: 10.1016/j.bcp.2025.117627
BMC endocrine disorders IF: 03.300Ahead of Print.No.96Comparison of logistic regression and artificial neural network models for predicting hypoglycemia in non-ICU inpatients with diabetes预测非ICU糖尿病患者低血糖：逻辑回归与人工神经网络模型的比较DOI: 10.1186/s12902-025-02125-6
Diabetologia IF: 10.200Ahead of Print.No.97LDHA induces beta cell dedifferentiation in diabetes through metabolic and epigenetic reprogrammingLDHA通过代谢与表观遗传重编程诱导糖尿病中的β细胞去分化DOI: 10.1007/s00125-025-06626-w
Molecular & cellular proteomics IF: 05.500Ahead of Print.No.98Plasma Proteomic Characterization of Adolescent Idiopathic Scoliosis青少年特发性脊柱侧凸的血浆蛋白质组特征DOI: 10.1016/j.mcpro.2025.101486
Biochem Biophys Res Commun IF: 02.200Ahead of Print.No.99Engineered MSCs secreting GLP-1 enhance β-cell survival and improve glycemic control in diabetic mice分泌GLP-1的工程化间充质干细胞增强β细胞存活并改善糖尿病小鼠血糖控制DOI: 10.1016/j.bbrc.2025.153105
Scientific reports IF: 03.900Volume 15, Issue 1No.100Information quality assessment and user engagement prediction of short videos about diabetic kidney disease on TikTok and bilibili抖音与哔哩哔哩平台上糖尿病肾病相关短视频的信息质量评估与用户参与度预测DOI: 10.1038/s41598-025-27650-1
Diabetology & metabolic syndrome IF: 03.900Ahead of Print.No.101Impact of metformin on intervertebral disc degeneration in patients with diabetes: a prospective cohort study from the UK biobank二甲双胍对糖尿病患者椎间盘退变的影响：一项基于英国生物样本库的前瞻性队列研究DOI: 10.1186/s13098-025-02050-7
Int J Biol Macromol IF: 08.500Ahead of Print.No.102Injectable adhesive self-healing hyaluronic acid-based hydrogel with microenvironment-responsive metformin delivery and photothermal antibacterial activity for diabetic infected wound healing用于糖尿病感染伤口愈合的可注射粘附自愈透明质酸基水凝胶：具有微环境响应性二甲双胍递送和光热抗菌活性DOI: 10.1016/j.ijbiomac.2025.149560
Biosensors & bioelectronics IF: 10.500Ahead of Print.No.103A skin-interfaced sensor for noninvasive monitoring of pharmacokinetic and pharmacodynamic responses用于无创监测药代动力学和药效学反应的皮肤接口传感器DOI: 10.1016/j.bios.2025.118301
Scientific reports IF: 03.900Volume 15, Issue 1No.104The role and potential mechanism of PEST-containing nuclear protein (PCNP) in endothelial cell angiogenesis in vitroPEST结构域核蛋白（PCNP）在体外内皮细胞血管生成中的作用和潜在机制DOI: 10.1038/s41598-025-27494-9
Photodiagnosis Photodyn Ther IF: 02.600Ahead of Print.No.105Prediction model for the risk of vitreous haemorrhage after vitrectomy combined with intraocular injection for the treatment of proliferative diabetic retinopathy预测增生性糖尿病视网膜病变患者玻璃体切除联合眼内注药术后玻璃体腔出血风险的模型DOI: 10.1016/j.pdpdt.2025.105313
Experimental Eye Research IF: 02.700Ahead of Print.No.106Autophagy and Mitophagy in Diabetic Retinopathy: The Effects and Mechanism of Action on the Neurovascular Unit自噬与线粒体自噬在糖尿病视网膜病变中的作用：对视神经血管单元的影响与机制DOI: 10.1016/j.exer.2025.110802
Biochemical pharmacology IF: 05.600Ahead of Print.No.107GLP-1 receptor agonists as a strategy to target ER stress in diabetic retinopathy以GLP-1受体激动剂为策略靶向内质网应激治疗糖尿病视网膜病变DOI: 10.1016/j.bcp.2025.117623
J Int Med Res IF: 01.500Volume 53, Issue 12No.108Noninvasive assessment of metabolic syndrome-related renal injury using magnetic resonance imaging fat fraction and apparent diffusion coefficient: A cross-sectional study应用磁共振成像脂肪分数与表观扩散系数无创评估代谢综合征相关肾损伤：一项横断面研究DOI: 10.1177/03000605251399039
Nature communications IF: 15.700Volume 16, Issue 1No.109Metabolomics of saliva, serum, and urine for pathogenesis, diagnosis, and prognosis in gestational diabetes mellitus基于唾液、血清和尿液代谢组学的妊娠期糖尿病发病机制、诊断与预后研究DOI: 10.1038/s41467-025-65992-6
Brain & development IF: 01.300Ahead of Print.No.110Construction and clinical validation of a fetal brain magnetic resonance imaging-prediction model based on multimodal AI fusion algorithm基于多模态AI融合算法的胎儿脑磁共振成像预测模型的构建与临床验证DOI: 10.1016/j.braindev.2025.104492
Diabetologia IF: 10.200Ahead of Print.No.111Declining FXR expression coordinates neonatal beta cell mass development with microbial bile acid metabolism maturation in miceFXR表达下降协调新生小鼠β细胞质量发育与微生物胆汁酸代谢成熟DOI: 10.1007/s00125-025-06618-w
Diabetology & metabolic syndrome IF: 03.900Ahead of Print.No.112Sex differences in metabolic syndrome among U.S. adolescents, NHANES 1999-2020美国青少年代谢综合征的性别差异：NHANES 1999-2020DOI: 10.1186/s13098-025-02052-5
BMC public health IF: 03.600Ahead of Print.No.113Outdoor food advertising landscape along school-age children's daily commute routes in Chengdu: implications for childhood obesity prevention成都学龄儿童日常通勤路线上的户外食品广告景观：对儿童肥胖预防的启示DOI: 10.1186/s12889-025-25806-2
BMC geriatrics IF: 03.800Ahead of Print.No.114Development of a sarcopenic obesity risk prediction model for older adults based on the CHARLS database基于CHARLS数据库的老年人肌肉减少性肥胖风险预测模型构建DOI: 10.1186/s12877-025-06688-w
BMC gastroenterology IF: 02.600Ahead of Print.No.115The causal relationship between body mass index and perianal abscess: a Mendelian randomization study体重指数与肛周脓肿的因果关系：一项孟德尔随机化研究DOI: 10.1186/s12876-025-04555-x
Clin Mol Hepatol IF: 16.900Ahead of Print.No.116Normal-weight MASLD: reclassification, characteristics, and adverse liver outcomes across diverse populations正常体重MASLD：不同人群中的重新分类、特征与不良肝脏结局DOI: 10.3350/cmh.2025.0851
Scientific reports IF: 03.900Ahead of Print.No.117Effects of excess bodyweight and flexible Flatfoot on female stance-phase lower-limb biomechanics assessed by statistical non-parametric mapping超重与柔性扁平足对女性站立期下肢生物力学的影响：基于统计非参数映射的评估DOI: 10.1038/s41598-025-32023-9
Nature communications IF: 15.700Volume 16, Issue 1No.118Gut Phage Biobank: a collection of bacteriophages targeting human commensal bacteria肠道噬菌体生物库：靶向人体共生细菌的噬菌体集合DOI: 10.1038/s41467-025-61946-0
Adipocyte IF: 03.100Volume 14, Issue 1No.119CAPG enhances adipogenesis and inflammatory cytokine expression in adipocytesCAPG促进脂肪细胞分化并增强炎症细胞因子表达DOI: 10.1080/21623945.2025.2549456
The American surgeon IF: 00.900Ahead of Print.No.120Role of Bariatric Surgery in Modulating Fetuin-A and Metabolic Outcomes: A Systematic Review and Meta-Analysis减重手术在调节Fetuin-A及代谢结局中的作用：一项系统综述和荟萃分析DOI: 10.1177/00031348251407347
Biochim Biophys Acta Mol Cell Biol Lipids IF: 03.300Ahead of Print.No.121MiR-424-3p suppresses adipogenesis via HNRNPA0 targeting and p53-mediated ferroptosisMiR-424-3p通过靶向HNRNPA0和p53介导的铁死亡抑制脂肪生成DOI: 10.1016/j.bbalip.2025.159712
Fitoterapia IF: 02.600Ahead of Print.No.122Pharmacological insights on multifaceted therapeutic applications of stilbenoids: A comprehensive updates二苯乙烯类化合物多面治疗应用的药理学见解：全面更新DOI: 10.1016/j.fitote.2025.107034
Cancer letters IF: 10.100Ahead of Print.No.123High-fat diet induced ECM remodeling attenuates chemosensitivity in prostate cancer via activating Piezo1-dependent mitochondria-ER contacts高脂饮食诱导细胞外基质重塑通过激活Piezo1依赖性线粒体-内质网接触减弱前列腺癌化疗敏感性DOI: 10.1016/j.canlet.2025.218204
European journal of pharmacology IF: 04.700Ahead of Print.No.124GLP-1RA partially alleviates obesity-induced reproductive dysfunction driven by the interplay mechanisms of inflammation and metabolic dysregulation via the SIRT-associated pathwayGLP-1受体激动剂通过SIRT关联通路部分缓解由炎症与代谢失调相互作用驱动的肥胖所致生殖功能障碍DOI: 10.1016/j.ejphar.2025.178459
Brain research IF: 02.600Ahead of Print.No.125Unforgettable food memories in overweight/obese individuals-Evidence from Think/No-Think experiment超重/肥胖个体中难以忘记的食物记忆——来自想/不想范式实验的证据DOI: 10.1016/j.brainres.2025.150108
Cell metabolism IF: 30.900Ahead of Print.No.126Macrophage PD-1 regulates energy expenditure and metabolic dysfunction under immune checkpoint blockade免疫检查点阻断下巨噬细胞PD-1调控能量消耗与代谢功能障碍DOI: 10.1016/j.cmet.2025.11.009
J Nutr Health Aging IF: 04.000Ahead of Print.No.127Dietary manganese, type 2 diabetes, and cardiovascular disease: A UK Biobank cohort study and meta-analysis of over 270,000 individuals膳食锰、2型糖尿病与心血管疾病：一项基于英国生物样本库的队列研究及针对超过27万人的荟萃分析DOI: 10.1016/j.jnha.2025.100754
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Scientific reports IF: 03.900Volume 15, Issue 1No.129Activated vitamin D(3) improves the microbiota and intestinal barrier in type 2 diabetic mice via modulating AMPK activation活性维生素D3通过调控AMPK激活改善2型糖尿病小鼠的肠道菌群及屏障功能DOI: 10.1038/s41598-025-27937-3
Scientific reports IF: 03.900Volume 15, Issue 1No.130Diabetes duration, glycemic control, and risk of stroke and stroke subtypes: a nationwide prospective cohort study糖尿病病程、血糖控制与卒中及卒中亚型风险：一项全国性前瞻性队列研究DOI: 10.1038/s41598-025-27547-z
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Scientific reports IF: 03.900Ahead of Print.No.132Cirsiliol alleviates diabetic cardiomyopathy by inhibiting oxidative stress and improving energy metabolism through the PPAR-α/AMPK pathwayCir醚醇通过PPAR-α/AMPK通路抑制氧化应激和改善能量代谢缓解糖尿病心肌病DOI: 10.1038/s41598-025-32157-w
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Artificial organs IF: 02.300Ahead of Print.No.53Impact of Heart Allocation Change on Selection and Adverse Events of Bridged-To-Transplant Durable Ventricular Assist Device Recipients心脏分配政策变更对移植前桥接用耐久性心室辅助装置患者的选择及不良事件的影响DOI: 10.1111/aor.70042
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Journal of neuroendocrinology IF: 04.100Ahead of Print.No.55Human growth hormone-induced mitotic maladaptation in podocytes and implications in diabetic kidney disease生长激素诱导的足细胞有丝分裂适应不良及其在糖尿病肾病中的意义DOI: 10.1111/jne.70122
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J Genet Eng Biotechnol IF: 02.800Volume 23, Issue 4No.67Eco-friendly synthesis of silver nanoparticles from the leaf blades extract of seagrass Thalassia hemprichii: Multifunctional agents for biomedical and environmental applications利用海草Thalassia hemprichii叶片提取物生态友好合成银纳米颗粒：生物医学与环境应用的多功能制剂DOI: 10.1016/j.jgeb.2025.100600
J Genet Eng Biotechnol IF: 02.800Volume 23, Issue 4No.68Isolation and characterization of peroxidase from potato leaves Solanum tuberosum: Application in glucose diagnostic kit马铃薯叶过氧化物酶的分离鉴定及其在葡萄糖诊断试剂盒中的应用DOI: 10.1016/j.jgeb.2025.100584
J Genet Eng Biotechnol IF: 02.800Volume 23, Issue 4No.69Loss-of-function variant of SLC30A8 rs13266634 (C > T) protects against type 2 diabetes by stabilizing ZnT8: Insights from epidemiological and computational analysesSLC30A8 rs13266634（C > T）功能缺失变异体通过稳定ZnT8对2型糖尿病具有保护作用：来自流行病学和计算分析的见解DOI: 10.1016/j.jgeb.2025.100565
Surgical infections IF: 01.400Ahead of Print.No.70Multi-factorial Hyperlactatemia Due to Linezolid and Metformin Treatment in the Setting of Vitamin C and B1 Deficiency利奈唑胺与二甲双胍治疗背景下合并维生素C及B1缺乏所致多因素性高乳酸血症DOI: 10.1177/10962964251401522
Proteomics IF: 03.900Ahead of Print.No.71Advancing Understanding of the Protein Composition of Human Seminal Extracellular Vesicles推进对人类精液细胞外囊泡蛋白质组成的理解DOI: 10.1002/pmic.70088
Fam Med Community Health IF: 04.300Volume 13, Issue 4No.72Insights into diabetes remission services: perspectives from general practitioners, family physicians and multidisciplinary teams深入了解糖尿病缓解服务：全科医生、家庭医生和多学科团队的视角DOI: 10.1136/fmch-2025-003631
Am J Med Genet A IF: 01.700Ahead of Print.No.73Identification of Compound Heterozygous CYP11A1 Variants via Reanalysis of Clinical Sequencing Data通过重新分析临床测序数据鉴定CYP11A1复合杂合变异DOI: 10.1002/ajmga.70008
JCE IF: 02.600Ahead of Print.No.74Near-Zero-Fluoroscopy Ablation of Atrial Fibrillation Without ICE or Non-Fluoroscopic Tracking Systems: Findings From the SHORT LOOK Registry不使用ICE或非透视跟踪系统的近零透视心房颤动消融：SHORT LOOK注册研究结果DOI: 10.1111/jce.70225
Int J Biol Macromol IF: 08.500Ahead of Print.No.75Fabrication of ferulic acid-decorated ZnO nanoparticles in a chitosan matrix: A bioactive powder for wound management阿魏酸修饰的ZnO纳米颗粒在壳聚糖基质中的制备：一种用于伤口管理的生物活性粉末DOI: 10.1016/j.ijbiomac.2025.149640
Canadian journal of diabetes IF: 02.600Ahead of Print.No.76Optimizing patient partner engagement and integration in research: Recommendations from a qualitative study of focus groups with patient partners living with type 1 or type 2 diabetes优化研究中患者伙伴的参与和整合：来自1型或2型糖尿病患者伙伴焦点小组定性研究的建议DOI: 10.1016/j.jcjd.2025.12.002
Biochimie IF: 03.000Ahead of Print.No.77A comprehensive review on the Advanced Glycation End Products detection: From conventional to advanced approaches晚期糖基化终末产物检测方法综述：从传统到先进手段DOI: 10.1016/j.biochi.2025.12.004
Ann Allergy Asthma Immunol IF: 04.700Ahead of Print.No.78Gestational diabetes and childhood lung function at age 8-9 years in a diverse US cohort美国一项多样族裔队列研究表明：妊娠期糖尿病与8-9岁儿童肺功能下降相关DOI: 10.1016/j.anai.2025.12.006
Exp Clin Endocrinol Diabetes IF: 01.700Ahead of Print.No.79Association of fibrosis index-4 (FIB-4) with chronic vascular complications of type 2 diabetes mellitus纤维化指数-4（FIB-4）与2型糖尿病慢性血管并发症的关联DOI: 10.1055/a-2765-6480
Diabetes & metabolic syndrome IF: 03.400Ahead of Print.No.80Assessing the quality and guideline-concordance of AI-powered chatbots in nutritional management of diabetes评估AI驱动聊天机器人在糖尿病营养管理中的质量与指南一致性DOI: 10.1016/j.dsx.2025.103355
Tissue & cell IF: 02.500Ahead of Print.No.81Membrane-engineered Wharton's Jelly derived mesenchymal stem cells with anti-CD2 antibody coating modulate activated CD3(+) T-cell responses膜工程化沃顿胶来源间充质干细胞联合抗CD2抗体涂层调节活化CD3(+) T细胞应答DOI: 10.1016/j.tice.2025.103274
Journal of plant physiology IF: 04.100Ahead of Print.No.82Triumphing over hidden hunger: Redesigning rice (Oryza sativa L.) for enhanced nutraceutical grain composition utilizing multiplexed genome editing战胜隐性饥饿：利用多重基因组编辑技术改良水稻的保健谷物成分DOI: 10.1016/j.jplph.2025.154667
JMIR research protocols IF: 01.500Volume 14, Issue No.83Co-Design of a Digital Health Platform for Chronic Disease Management in Rural Settings Using a Person-Centered, Collaborative-Care Model: Protocol for a 3-Phase Mixed Methods Study采用以人为本、协作护理模式在农村环境中共同设计慢性病管理数字健康平台：一项三阶段混合方法研究方案DOI: 10.2196/77844
PloS one IF: 02.600Volume 20, Issue 12No.84Hyperglycemia and bladder cancer prognosis in a Finnish population-based cohort高血糖与芬兰人群队列中膀胱癌预后的关系DOI: 10.1371/journal.pone.0338215
Advances in physiology education IF: 01.700Ahead of Print.No.85Endometriosis: Pathophysiology and the Potential Role of Diet子宫内膜异位症：病理生理学与饮食的潜在作用DOI: 10.1152/advan.00198.2025
Pancreas IF: 01.700Ahead of Print.No.86Internet-delivered Cognitive-behavioral Intervention for Pain in Pediatric Acute Recurrent and Chronic Pancreatitis: A Multicenter Randomized Controlled Trial针对儿童急性复发性及慢性胰腺炎疼痛的互联网提供认知行为干预：一项多中心随机对照试验DOI: 10.1097/MPA.0000000000002558
Cell reports IF: 06.900Ahead of Print.No.87VIP interneuron activity during sleep conveys the cortical infraslow oscillation睡眠中VIP中间神经元的活动传导皮层超慢振荡DOI: 10.1016/j.celrep.2025.116669
The Journal of frailty & aging IF: 03.300Ahead of Print.No.88Association between diabetes and frailty, and the moderating role of sex in that association in older adults of the ELSA-Brasil study老年糖尿病与衰弱的关系及性别在其中的调节作用：ELSA-Brasil研究DOI: 10.1016/j.tjfa.2025.100115
Clin J Am Soc Nephrol IF: 07.100Ahead of Print.No.89Efficacy, Mechanisms and Safety of Sodium-Glucose Cotransporter-2 Inhibitors in Kidney Transplant Recipients: A Randomized, Double-Blind, Placebo-Controlled Trial钠-葡萄糖协同转运蛋白2抑制剂在肾移植受者中的有效性、机制与安全性：一项随机、双盲、安慰剂对照试验DOI: 10.2215/CJN.0000000951
Clin J Am Soc Nephrol IF: 07.100Ahead of Print.No.90Comparison of Low eGFR Prevalence and Prediction for Mortality Using 2009 and 2021 CKD-EPI Equations in Mexican Adults使用2009与2021年CKD-EPI方程比较墨西哥成人中低eGFR患病率及其对死亡率的预测价值DOI: 10.2215/CJN.0000000933
PloS one IF: 02.600Volume 20, Issue 12No.91Mapping the microRNA-mediated crosstalk between insulin resistance and Alzheimer's disease: A computational genomic insight绘制胰岛素抵抗与阿尔茨海默病之间由microRNA介导的交互作用图谱：一项计算基因组学视角DOI: 10.1371/journal.pone.0329056
Cell reports IF: 06.900Ahead of Print.No.92DEC1 regulates human β cell functional maturation and circadian rhythmDEC1调控人类β细胞功能成熟与昼夜节律DOI: 10.1016/j.celrep.2025.116666
Kidney360 IF: 03.000Ahead of Print.No.93Emerging Therapies in Autosomal Dominant Polycystic Kidney Disease常染色体显性多囊肾病的新兴疗法DOI: 10.34067/KID.0000001109
Appl Physiol Nutr Metab IF: 02.000Ahead of Print.No.94Bottle to Body: How Multivitamin/Mineral Supplements Shape Canadian Nutrient Intake从补充剂到身体：复合维生素/矿物质补充剂如何影响加拿大人的营养摄入DOI: 10.1139/apnm-2025-0305
Am J Physiol Endocrinol Metab IF: 03.100Ahead of Print.No.95RYGB Induces Vagal Sensory Neuropathy Characterized by Altered GLP1R Expression and Enhanced Exendin-4 Responsiveness in Male Mice胃旁路术诱导迷走神经感觉神经病变，其特征为GLP1R表达改变和Exendin-4反应性增强DOI: 10.1152/ajpendo.00452.2025
AIDS care IF: 01.200Ahead of Print.No.96Association between diet quality, physical activity and anthropometric status of people living with HIV in Cape Town开普敦HIV感染者的饮食质量、体力活动与人体测量学状况之间的关联DOI: 10.1080/09540121.2025.2586244
PloS one IF: 02.600Volume 20, Issue 12No.97Public knowledge and awareness of obstructive sleep apnea in Saudi Arabia: A population-based study of over 16,000 adults沙特阿拉伯公众对阻塞性睡眠呼吸暂停的知识与认知：一项基于超过1.6万名成年人的群体研究DOI: 10.1371/journal.pone.0337822
Clin J Am Soc Nephrol IF: 07.100Ahead of Print.No.98Sodium-Glucose Cotransporter-2 Inhibitors and Ketoacid Diets for Diabetic Kidney Disease钠-葡萄糖协同转运蛋白-2抑制剂与酮酸饮食治疗糖尿病肾病DOI: 10.2215/CJN.0000000958
Kidney360 IF: 03.000Ahead of Print.No.99Targeting αvβ8 Integrin with Monoclonal Antibody MEDI8367 Prevents Fibrosis in Preclinical Models of CKD单克隆抗体MEDI8367靶向αvβ8整合素可在慢性肾病临床前模型中预防纤维化DOI: 10.34067/KID.0000001006
Journal of medicinal chemistry IF: 06.800Ahead of Print.No.100Design, Optimization, and Biological Evaluation of First-in-Class Triple Inhibitors of SGLT1, SGLT2, and DPP4 for Type 2 Diabetes Mellitus针对2型糖尿病的SGLT1、SGLT2与DPP4三重抑制剂的研发、优化与生物学评价DOI: 10.1021/acs.jmedchem.5c02225
PloS one IF: 02.600Volume 20, Issue 12No.101Shift from visceral to subcutaneous adipose tissue in Cyp17a1-knockout rats prevents the progression of metabolic syndromeCyp17a1基因敲除大鼠脂肪从内脏向皮下转移阻止代谢综合征进展DOI: 10.1371/journal.pone.0311478
Fundam Clin Pharmacol IF: 02.500Volume 40, Issue 1No.102Gabapentinoids and Neuropathic Pain: Evaluation of the Quality of Randomised Controlled Trials: An Umbrella Review加巴喷丁与神经病理性疼痛：随机对照试验质量的评估：一项伞状评价DOI: 10.1111/fcp.70052
J Racial Ethn Health Disparities IF: 02.400Ahead of Print.No.103A Scoping Review of Racial Identity, Racial Socialization, and Africentric Worldview in the Context of Obesity in Black Adolescent Females黑人少女肥胖背景下的种族认同、种族社会化与非洲中心世界观：一项范围综述DOI: 10.1007/s40615-025-02678-1
Matern Child Health J IF: 01.700Ahead of Print.No.104Low Calcium Intake in High-Risk Pregnant Women: What are the Associated Factors?高危孕妇钙摄入不足：相关因素有哪些？DOI: 10.1007/s10995-025-04200-9
Hernia IF: 02.400Volume 30, Issue 1No.105Enhancing prediction of incisional hernia in liver transplant patients: performance assessment and stepwise revision of a prognostic model提升肝移植患者切口疝的预测能力：一项预后模型的性能评估与逐步修订DOI: 10.1007/s10029-025-03508-3
West J Nurs Res IF: 01.700Ahead of Print.No.106Factors Related to Binge Eating in Korean American Women韩国裔美国女性暴食相关因素研究DOI: 10.1177/01939459251391989
Endocrine connections IF: 02.800Ahead of Print.No.107Short-term changes in des-acyl ghrelin following bariatric surgery减重手术后脱酰基生长激素释放肽的短期变化DOI: 10.1530/EC-25-0325
Vopr Kurortol Fizioter Lech Fiz KultVolume 102, Issue 5. Vyp. 2No.108[Effective management of biological age and quality of life in patients based on the integrated use of pathogenetically focused medical rehabilitation methods]基于病理生理学导向医疗康复方法整合应用有效管理患者生物学年龄与生活质量DOI: 10.17116/kurort202510205281
Vopr Kurortol Fizioter Lech Fiz KultVolume 102, Issue 5. Vyp. 2No.109[The informative value of methods for diagnosing aging and the development of prognostic criteria for the effectiveness of complex physiotherapy for managing active longevity]诊断衰老方法的信息价值及制定综合物理疗法管理积极长寿疗效的预后标准DOI: 10.17116/kurort202510205235
Cancer prevention research IF: 02.600Ahead of Print.No.110Uncovering the Red Flags: A Cross-Sectional Retrospective Case-Control Study on Predictors of Early Onset Colorectal Cancer in a Multi-State Community Health System揭示危险信号：一项多州社区医疗系统中早发性结直肠癌预测因素的横断面回顾性病例对照研究DOI: 10.1158/1940-6207.CAPR-25-0232
Indian Journal of Ophthalmology IF: 01.800Ahead of Print.No.111Ocular warnings of a silent killer: A case series on intracranial aneurysms无声杀手的眼部预警：颅内动脉瘤病例系列研究DOI: 10.4103/IJO.IJO_1543_25
J Endocrinol Invest IF: 03.500Ahead of Print.No.112Circulating 1,5-anhydroglucitol levels combined with pre-pregnancy BMI is a simple predictive marker of future glucose intolerance in women with gestational diabetes循环1,5-脱水葡萄糖醇水平联合孕前BMI是妊娠糖尿病女性未来葡萄糖不耐受的简单预测标志物DOI: 10.1007/s40618-025-02768-1
Diabetologia IF: 10.200Ahead of Print.No.113Impact of normoglycaemia and prediabetes definitions on the estimated benefits of regression from prediabetes to normoglycaemia for type 2 diabetes risk. Reply to Choi W [Letter]基于正常血糖与糖尿病前期不同定义评估从糖尿病前期回归正常血糖状态对降低2型糖尿病风险的估计影响——答Choi W来信DOI: 10.1007/s00125-025-06641-x
European journal of pediatrics IF: 02.600Volume 185, Issue 1No.114About potential value and limitations of continuous glucose monitoring in DKA连续葡萄糖监测在糖尿病酮症酸中毒中的潜在价值与局限性探讨DOI: 10.1007/s00431-025-06684-7
Indian journal of pediatrics IF: 02.000Ahead of Print.No.115Pattern and Persistence of Islet Autoantibodies and their Immunogenetic Association among Type 1 Diabetes Patients from North India北印度1型糖尿病患者胰岛自身抗体模式、持续性及其免疫遗传学关联DOI: 10.1007/s12098-025-05882-3
Obesity surgery IF: 03.100Ahead of Print.No.116Correction: Metabolic Surgery for Obese Type 2 Diabetes: Korean Multicenter Cohort Study代谢外科手术治疗肥胖型2型糖尿病：韩国多中心队列研究DOI: 10.1007/s11695-025-08413-3
Hernia IF: 02.400Volume 30, Issue 1No.117Factors associated with venous thromboembolism in retromuscular ventral hernia repair - an abdominal core health quality collaborative analysis腹后间隙腹疝修补术中静脉血栓栓塞的相关因素分析——基于腹壁核心健康质量协作组数据库的研究DOI: 10.1007/s10029-025-03530-5
HNO IF: 01.300Ahead of Print.No.118[Diagnosis and management of necrotizing otitis externa]坏死性外耳道炎的诊断与管理DOI: 10.1007/s00106-025-01690-5
Diabetes IF: 07.500Ahead of Print.No.119miR-494 Deletion Improves Glucose Metabolism Independently of Obesity in MicemiR-494缺失独立于肥胖改善小鼠葡萄糖代谢DOI: 10.2337/db25-0355
Endocrine connections IF: 02.800Volume 14, Issue 12No.120Diagnostic accuracy of the triptorelin stimulation test for central precocious puberty in girls曲普瑞林刺激试验对女孩中枢性性早熟的诊断准确性DOI: 10.1530/EC-25-0642
Nephrol Dial Transplant IF: 05.600Ahead of Print.No.121Fasting urine osmolality and risk of kidney disease progression in patients with type 2 diabetes空腹尿渗透压与2型糖尿病患者肾脏疾病进展风险的关系DOI: 10.1093/ndt/gfaf264
Biomaterials science IF: 05.700Ahead of Print.No.122Bioresorbable-bioactive auxetic "personalised" phalanx with a CT-guided AI-driven model towards in vivo prediction of bone regeneration生物可吸收-生物活性拉胀结构“个性化”指骨：一种基于CT引导和AI驱动的模型，用于体内骨再生预测DOI: 10.1039/d5bm01337b
Health promotion international IF: 02.400Volume 40, Issue 6No.123An exploration of cultural grounding in Indigenous health promotion: perspectives from First Nations communities in Canada探索土著健康促进中的文化根基：来自加拿大原住民社区的视角DOI: 10.1093/heapro/daaf211
MS. Me?decine sciences IF: 00.400Volume 41, Issue 11No.124[Cell therapy of diabetes in France: from islet transplantation to future perspectives]法国糖尿病细胞疗法：从胰岛移植到未来展望DOI: 10.1051/medsci/2025161
J Pediatr Gastroenterol Nutr IF: 02.600Ahead of Print.No.125Vibration-controlled transient elastography in pediatric metabolic dysfunction-associated steatotic liver disease振动控制瞬时弹性成像技术在儿科代谢功能障碍相关脂肪性肝病中的应用DOI: 10.1002/jpn3.70284
European thyroid journal IF: 04.300Ahead of Print.No.126Selenium supplementation in individuals with newly diagnosed Graves' hyperthyroidism: A double-blind, multi-centre RCT新诊断Graves甲状腺功能亢进症患者的硒补充：一项双盲、多中心随机对照试验DOI: 10.1530/ETJ-25-0264
Acta Bioeng Biomech IF: 00.800Volume 27, Issue 3No.127A novel data mining approach for early diagnosis of gestational diabetes mellitus (GDM) in pregnancy via machine learning methods and CNN通过机器学习方法与CNN实现妊娠期糖尿病（GDM）早期诊断的一种新型数据挖掘方法DOI: 10.37190/abb/209528
Monaldi Arch Chest Dis IF: 01.100Ahead of Print.No.128Coronary plaques and pericardial fat volume assessment in patients with metabolic syndrome being evaluated for suspected coronary artery disease代谢综合征疑诊冠心病患者冠状动脉斑块特征与心包脂肪体积的评估DOI: 10.4081/monaldi.2025.3390
Am J Gastroenterol IF: 07.600Ahead of Print.No.129Glucagon-like peptide-1 receptor agonist treatment and risk of esophageal cancer胰高血糖素样肽-1受体激动剂治疗与食管癌风险DOI: 10.14309/ajg.0000000000003885
Endocrine connections IF: 02.800Ahead of Print.No.130Changes in Fibroblast Growth Factor 21 Levels Associated with Alcohol Consumption and Smoking Cessation与饮酒和戒烟相关的成纤维细胞生长因子21水平变化DOI: 10.1530/EC-25-0713
Daru IF: 02.100Volume 34, Issue 1No.131Resveratrol and caffeic acid attenuate diet-induced obesity by inhibiting the SREBP-1/ACLY lipogenic axis in adipose tissue of rats白藜芦醇与咖啡酸通过抑制脂肪组织中的SREBP-1/ACLY脂生成轴来减轻大鼠饮食诱导的肥胖DOI: 10.1007/s40199-025-00582-x
Am J Gastroenterol IF: 07.600Ahead of Print.No.132Poor Sensitivity of the Fatty Liver Index Among Lean Individuals脂肪肝指数在瘦人中的敏感性较差DOI: 10.14309/ajg.0000000000003883
Assist Inferm Ric IF: 00.900Volume 44, Issue 4No.133[Obesity as a chronic disease: the key role of new therapies]肥胖作为慢性疾病：新疗法的关键作用DOI: 10.1702/4616.46253
Pregnancy Hypertension IF: 02.900Volume 43, Issue No.134The impact of maternal chronic hypertension in pregnancy on offspring long-term respiratory morbidity妊娠期母亲慢性高血压对后代长期呼吸系统发病率的影响DOI: 10.1016/j.preghy.2025.101405
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.135P021 A case of radiation-induced haemorrhagic bullous lichen sclerosus of the breast一例乳腺癌放疗后诱发的出血性大疱性硬化性苔藓病例DOI: 10.1093/bjd/ljaf085.049
Frontiers in pharmacology IF: 04.800Volume 16, Issue No.136Efficacy and safety of Centella asiatica (L.) Urb. [Apiaceae] as a dietary supplement for glycemic control and lipid regulation in patients with type 2 diabetes: a randomized controlled trial in Thailand积雪草（Centella asiatica (L.) Urb. [Apiaceae]）作为膳食补充剂用于2型糖尿病患者血糖控制与血脂调节的有效性与安全性：一项泰国随机对照试验DOI: 10.3389/fphar.2025.1680647
Rom J Morphol Embryol IF: 01.500Volume 66, Issue 3No.137The influence of diabetes mellitus on blood vessels' amounts and immune status in case of breast cancer糖尿病对乳腺癌患者血管数量及免疫状态的影响DOI: 10.47162/RJME.66.3.12
Plant Physiol Biochem IF: 05.700Volume 229, Issue Pt CNo.138Encapsulated GABA coatings as a postharvest strategy to enhance mango chilling tolerance包封GABA涂层作为增强芒果采后耐冷性的策略DOI: 10.1016/j.plaphy.2025.110644
Diabetes Metab Syndr Obes IF: 03.000Volume 18, Issue No.139Quality of Life and Diabetic Complications Among Type 2 Diabetes Patients Across Healthcare Levels in Bandung, Indonesia印尼万隆市不同医疗层级2型糖尿病患者的生活质量与糖尿病并发症DOI: 10.2147/DMSO.S549279
Biology open IF: 01.700Ahead of Print.No.140miR-302 regulates pancreatic progenitor pool and pancreatic sizemiR-302调控胰腺祖细胞池与胰腺大小DOI: 10.1242/bio.062353
Transplant international IF: 03.000Volume 38, Issue No.141Death and Graft Loss in Simultaneous Pancreas-Kidney Recipients by Donor-Recipient Cytomegalovirus Serostatus in the United States基于供受者巨细胞病毒血清状态的美国同期胰腺-肾移植受者死亡与移植物丢失分析DOI: 10.3389/ti.2025.15653
Frontiers in health services IF: 02.700Volume 5, Issue No.142The DIAMONDS intervention for type 2 diabetes for people with severe mental illness: findings from a single-group feasibility study针对严重精神疾病患者的2型糖尿病DIAMONDS干预措施：单组可行性研究结果DOI: 10.3389/frhs.2025.1688787
J Biostat Biom ApplVolume 9, Issue 1No.143Factors Affecting Time to Return to a Normal Level of Hba1c Among Diabetes Mellitus Patients at Hawassa University Comprehensive Specialized Hospital, Hawassa, Ethiopia影响糖尿病患者糖化血红蛋白恢复至正常水平时间的因素https://pubmed.ncbi.nlm.nih.gov/41384241
Curēus IF: 01.300Volume 17, Issue 11No.144Evaluation of the Analytical Performance of a High-Precision Immunoassay for the Creatine Kinase-MB Isoenzyme高精度肌酸激酶-MB同工酶免疫测定方法的分析性能评估DOI: 10.7759/cureus.96457
Curēus IF: 01.300Volume 17, Issue 11No.145Unlocking the Potential of Negative Pressure Wound Therapy in Diabetic Foot Ulcers: A Systematic Review and Meta-Analysis解锁负压伤口疗法在糖尿病足溃疡中的潜力：一项系统综述与荟萃分析DOI: 10.7759/cureus.96474
Frontiers in oral health IF: 03.100Volume 6, Issue No.146Dental implant failure and retrieval techniques; a scoping review种植牙失败与取出技术：一项范围性综述DOI: 10.3389/froh.2025.1667808
JCEM case reportsVolume 4, Issue 1No.147Central Precocious Puberty and Hypothalamic Teratoma中枢性性早熟与下丘脑畸胎瘤DOI: 10.1210/jcemcr/luaf275
Caspian J Intern Med IF: 01.000Volume 16, Issue 4No.148Relationship between thyroid nodule, prolactin, and thyroid peroxidase antibody levels: A case-control study甲状腺结节、泌乳素与甲状腺过氧化物酶抗体水平的关系：一项病例对照研究DOI: 10.22088/cjim.16.4.712
bioRxivVolume 2025, Issue No.149EXPERIMENTAL CHARACTERIZATION OF BALLOON ANGIOPLASTY IN HUMAN FEMOROPOPLITEAL ARTERIES WITH DIFFERENT CALCIUM BURDENS不同钙负荷人体股腘动脉中球囊血管成形术的实验特征DOI: 10.1101/2025.11.27.691029
Clinical case reports IF: 00.600Volume 13, Issue 12No.150Myiasis of the Mastoid Cavity: Case Report乳突腔蝇蛆病：病例报告DOI: 10.1002/ccr3.71671
NeuroprotectionVolume 3, Issue 1No.151Decoding the role of large heat shock proteins in the progression of neuroinflammation-mediated neurodegenerative disorders解码大热休克蛋白在神经炎症介导的神经退行性疾病进展中的作用DOI: 10.1002/nep3.68
Skin appendage disorders IF: 01.300Ahead of Print.No.152Retrospective Analysis of Nail Changes and Comorbidities in Darier Disease达里埃病甲改变与合并症的回顾性分析DOI: 10.1159/000549631
Frontiers in nutrition IF: 05.100Volume 12, Issue No.153Consumption of commercial and traditional sugar-sweetened beverages among adolescents in Pakistan: evidence from a national survey巴基斯坦青少年商业和传统含糖饮料消费情况：基于全国调查的证据DOI: 10.3389/fnut.2025.1679917
Rev Panam Salud Publica IF: 02.200Volume 49, Issue No.154[Factors associated with cardiometabolic disease screening in older adults in the Peruvian AmazonFatores associados ao rastreamento de doenças cardiometabólicas em pessoas idosas da Amazônia peruana]秘鲁亚马逊地区老年人心脏代谢疾病筛查的相关因素分析DOI: 10.26633/RPSP.2025.118
Rev Panam Salud Publica IF: 02.200Volume 49, Issue No.155[Implementation of hypertension and diabetes care pathways in two regions of the Brazilian NortheastImplementación de las líneas de cuidado para la hipertensión y la diabetes en dos regiones del nordeste brasileño]巴西东北部两个地区高血压与糖尿病护理路径的实施DOI: 10.26633/RPSP.2025.117
Rev Panam Salud Publica IF: 02.200Volume 49, Issue No.156[Nursing consultations in primary health care in Brazil: distribution and productivity in the management of chronic noncommunicable diseasesConsultas atendidas por personal de enfermería en la atención primaria de salud en Brasil: distribución y productividad en las consultas relativas a enfermedades crónicas no transmisibles]巴西初级卫生保健中的护理咨询：慢性非传染性疾病管理的分布与生产率DOI: 10.26633/RPSP.2025.115
Sage open agingVolume 11, Issue No.157Factors Associated With Subjective Wellbeing in Community-Dwelling Homebound Older Adults With Diabetes in the US美国居家不便老年糖尿病患者主观幸福感的相关因素研究DOI: 10.1177/30495334251404290
Frontiers in neurology IF: 02.800Volume 16, Issue No.158SAFE-CGRP study: multicenter retrospective evaluation of the safety of CGRP pathway-targeting monoclonal antibodies in migraine with relevant comorbidities or conditions excluded from trialsSAFE-CGRP研究：针对CGRP通路单克隆抗体在具有临床试验排除的相关合并症偏头痛患者中的多中心回顾性安全性评价DOI: 10.3389/fneur.2025.1703876
J Diabetes Sci Technol IF: 03.700Ahead of Print.No.159Creation and Evaluation of a Research Participant Portal for the University of Chicago Monogenic Diabetes Registry创建和评估芝加哥大学单基因糖尿病注册研究参与者门户DOI: 10.1177/19322968251399666
Rom J Morphol Embryol IF: 01.500Volume 66, Issue 3No.160Leveraging artificial intelligence for cardiovascular risk: a primary care perspective基于人工智能的心血管风险评估：来自初级医疗的视角DOI: 10.47162/RJME.66.3.13
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.161P082 The WHO-5 wellbeing measure as an assessment tool in inflammatory skin diseasesWHO-5幸福感量表作为炎症性皮肤病的评估工具DOI: 10.1093/bjd/ljaf085.110
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.162P105 Lebrikizumab improves quality of life and wellbeing of patients with moderate-to-severe atopic dermatitis inadequately controlled with or ineligible for ciclosporin: German extension results (week 76) of the ADvantage studyLebrikizumab改善对环孢素控制不佳或不适合使用的中重度特应性皮炎患者的生活质量及幸福感：ADvantage研究德国延长期（第76周）结果DOI: 10.1093/bjd/ljaf085.133
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.163BH20 A multicentre analysis of the adequacy of alopecia horizontal biopsy samples over 10 years一项十年期多中心分析：脱发水平活检样本的充分性DOI: 10.1093/bjd/ljaf085.241
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.164O05 A retrospective review of cases of psoriasis requiring discontinuation of biologic therapy from 2007 to 2024 in a multisite NHS trust一项对2007年至2024年间多中心NHS信托银屑病需停用生物制剂病例的回顾性研究DOI: 10.1093/bjd/ljaf085.020
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.165BG12 Carotenaemia: a persistent orange hueBG12 胡萝卜素血症：一种持续性的橙色调DOI: 10.1093/bjd/ljaf085.358
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.166CPC12 An unusual case of paraneoplastic sarcoid presenting as dactylitis病例报告12：表现为指趾炎的副肿瘤性结节病一例DOI: 10.1093/bjd/ljaf085.012
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.167BH13 Itchy feet: skin and nail conditions in the podiatrists' clinic足部瘙痒：足病诊所中的皮肤与指甲问题DOI: 10.1093/bjd/ljaf085.234
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.168PA43 An infrequently diagnosed cause of pruritusPA43 一个罕见诊断的瘙痒病因DOI: 10.1093/bjd/ljaf085.402
The annals of pharmacotherapy IF: 02.300Ahead of Print.No.169Vildagliptin-Associated Acquired Hemophilia A维格列汀相关的获得性血友病ADOI: 10.1177/10600280251403095
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.170P110 Low prevalence of liver fibrosis in patients with atopic dermatitis on methotrexate甲氨蝶呤治疗的特应性皮炎患者肝纤维化患病率较低DOI: 10.1093/bjd/ljaf085.138
Plastic surgery IF: 00.600Ahead of Print.No.171Effect of Body Contouring Procedures on Changes in Long-Term Weight and Metabolic Health身体轮廓整形手术对长期体重及代谢健康变化的影响DOI: 10.1177/22925503251400374
Health science reports IF: 02.100Volume 8, Issue 12No.172Comparative Effectiveness of Insulin Versus Oral Hypoglycemic Agents in Diabetic Patients With Acute Stroke: A Retrospective Cross-Sectional Analysis of Treatment Outcomes and Influencing Factors胰岛素与口服降糖药在伴有急性卒中的糖尿病患者中的疗效比较：治疗结局及影响因素的回顾性横断面分析DOI: 10.1002/hsr2.71598
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.173SG02 Transdermal testosterone improves lower-extremity ulceration in a young man with newly diagnosed Klinefelter syndrome (47 XXY)经皮睾酮改善新诊断47XXY克氏综合征年轻男性下肢溃疡DOI: 10.1093/bjd/ljaf085.511
Caspian J Intern Med IF: 01.000Volume 16, Issue 4No.174Association of celiac disease with type 1 diabetes: A cross-sectional analysis in 2022乳糜泻与1型糖尿病的关联：一项2022年的横断面分析DOI: 10.22088/cjim.16.4.797
Pediatric diabetes IF: 05.600Volume 2025, Issue No.175Exploring the Influence of a Diabetes Specialty Outpatient Clinic on Adolescents With Type 1 Diabetes in Barbados: A Qualitative Study探索巴巴多斯糖尿病专科门诊对1型糖尿病青少年的影响：一项定性研究DOI: 10.1155/pedi/5454172
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.176CD02 Colophonium derivatives as key allergens in diabetes technology-associated allergic contact dermatitis: a hidden concern in the British Society for Cutaneous Allergy standard seriesCD02：松香衍生物是糖尿病技术相关过敏性接触性皮炎的关键过敏原——英国皮肤过敏学会标准系列中的一个隐忧DOI: 10.1093/bjd/ljaf085.271
Frontiers in physiology IF: 03.400Volume 16, Issue No.177Impact of vascular density on pancreatic islet viability: a computational study血管密度对胰岛细胞活力的影响：一项计算研究DOI: 10.3389/fphys.2025.1707026
RSC advances IF: 04.600Volume 15, Issue 57No.178Nanoliposome-based drug delivery systems for the treatment of diabetes mellitus: a review糖尿病治疗：纳米脂质体药物递送系统综述DOI: 10.1039/d5ra07152f
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.179Scars of oxidative stress: protein carbonylation and beta cell dysfunction in diabetes氧化应激的疤痕：蛋白羰基化与糖尿病中的β细胞功能障碍DOI: 10.3389/fendo.2025.1722623
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.180The frequency of polycystic ovary syndrome in women with prediabetes compared with normoglycemic women与血糖正常女性相比，糖尿病前期女性中多囊卵巢综合征的发生率DOI: 10.3389/fendo.2025.1722978
Veterinary medicine and science IF: 01.700Volume 12, Issue 1No.181Effect of Feeding Cottonseed Meal With or Without NSP Enzymes on Growth Performance, Blood Biochemistry, Growth-Related Gene Expression, Intestinal Health and Economic Efficiency in Broilers饲喂添加或不添加NSP酶的棉籽粕对肉鸡生长性能、血液生化、生长相关基因表达、肠道健康和经济效率的影响DOI: 10.1002/vms3.70723
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.182CD19 Contact allergy to colophonium and Abitol in a continuous glucose monitor securing tapeCD19 对连续血糖监测仪固定胶带中松香和松香醇的接触性过敏DOI: 10.1093/bjd/ljaf085.288
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.183P024 Anakinra for recalcitrant pyoderma gangrenosum with Achilles tendon exposureP024 阿那白滞素治疗伴跟腱暴露的顽固性坏疽性脓皮病DOI: 10.1093/bjd/ljaf085.052
Caspian J Intern Med IF: 01.000Volume 16, Issue 4No.184Association between triglyceride-glucose index and nephrolithiasis among the elderly in Amirkola: A cross-sectional population-based studyAmirkola地区老年人群甘油三酯-葡萄糖指数与肾结石的关联：一项基于人群的横断面研究DOI: 10.22088/cjim.16.4.741
J Clin Endocrinol Metab IF: 05.100Ahead of Print.No.185Visceral adipose tissue and liver fat on 17-beta estradiol-dominant gender-affirming hormone therapy: A US-based cohort美国队列研究：17β-雌二醇主导的性别肯定激素治疗对内脏脂肪组织及肝脏脂肪的影响DOI: 10.1210/clinem/dgaf665
BioFactors IF: 05.000Volume 51, Issue 6No.186Extracellular Vesicles Released From Prostate Cancer Cells Confer Pro-Tumor Properties to Adipocytes by Stimulating Lipolysis前列腺癌细胞释放的胞外囊泡通过刺激脂解作用赋予脂肪细胞促肿瘤特性DOI: 10.1002/biof.70067
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.187PA41 Treating severe nodulocystic acne with isotretinoin in children with cystic fibrosis使用异维A酸治疗囊性纤维化儿童的严重结节囊肿性痤疮DOI: 10.1093/bjd/ljaf085.400
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.188P070 Effect of insulin resistance on treatment response in moderate-to-severe psoriasis: a retrospective study胰岛素抵抗对中重度银屑病治疗效果的影响：一项回顾性研究DOI: 10.1093/bjd/ljaf085.098
Journal of diabetes research IF: 03.400Volume 2025, Issue No.189Longitudinal Study on the Progression of Diabetes Mellitus Patients at Jimma University Specialized Hospital, Ethiopia埃塞俄比亚Jimma大学专科医院糖尿病患者的纵向研究DOI: 10.1155/jdr/7035393
Caspian J Intern Med IF: 01.000Volume 16, Issue 4No.190Carotid sonographic features in Takayasu's arteritis: A case-control study高安动脉炎的颈动脉超声特征：一项病例对照研究DOI: 10.22088/cjim.16.4.747
NeuroprotectionVolume 3, Issue 2No.191Beta cells to brain cells: The pivotal role of insulin and glucose metabolism in Alzheimer's disease从β细胞到脑细胞：胰岛素与葡萄糖代谢在阿尔茨海默病中的关键作用DOI: 10.1002/nep3.70008
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.192BC06 Investigating the role of metformin in melasma management: a review探究二甲双胍在黄褐斑管理中的作用：一篇综述DOI: 10.1093/bjd/ljaf085.219
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.193P111 A multicentre service evaluation highlighting the variable off-label prescribing practice of spironolactone in the management of hidradenitis suppurativa: the need for evidence-based guidelines一项多中心服务评估揭示螺内酯治疗化脓性汗腺炎的标签外处方实践差异显著：凸显循证指南的必要性DOI: 10.1093/bjd/ljaf085.139
Curēus IF: 01.300Volume 17, Issue 11No.194Initial Institutional Experience and Workflow of Biology-Guided Radiotherapy (BgRT) for a Patient With Non-small Cell Lung Cancer针对非小细胞肺癌患者的生物引导放疗（BgRT）：机构初步经验与工作流程DOI: 10.7759/cureus.96513
Frontiers in digital health IF: 03.800Volume 7, Issue No.195Dissecting the difference between positive and negative brain health sentiment using X data剖析X平台数据中脑健康正负面情绪差异DOI: 10.3389/fdgth.2025.1648671
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.196PS11 Successful treatment of chronic pruritus and secondary ulceration with aprepitant阿瑞匹坦成功治疗慢性瘙痒和继发性溃疡DOI: 10.1093/bjd/ljaf085.509
Eur J Transl Myol IF: 01.800Ahead of Print.No.197Analysis of the Effects of Dapagliflozin on Cardiac Myocyte Injury Markers and Left Ventricular Diastolic Function in Heart Failure Patients with Preserved Ejection Fraction after PCI达格列净对PCI术后射血分数保留心力衰竭患者心肌损伤标志物及左心室舒张功能的影响分析DOI: 10.4081/ejtm.2025.14272
Clinical ophthalmology IF: 02.200Volume 19, Issue No.198Structural and Functional Outcomes of Optic Pathway Compression in Pituitary Adenoma: A Prospective Pilot OCT Study垂体腺瘤视通路压迫的结构与功能转归：一项前瞻性OCT试点研究DOI: 10.2147/OPTH.S556193
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.199P121 Treatment with semaglutide improves the systemic inflammatory burden associated with hidradenitis suppurativa司美格鲁肽治疗改善化脓性汗腺炎相关的全身炎症负担DOI: 10.1093/bjd/ljaf085.149
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.200BH10 Nailing the diagnosis从指甲入手明确诊断DOI: 10.1093/bjd/ljaf085.231
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.201DP11 A case of Langerhans cell histiocytosis masquerading as lymphocytic hypophysitis and panhypopituitarism伪装成淋巴细胞性垂体炎和全垂体功能减退症的朗格汉斯细胞组织细胞增生症一例DOI: 10.1093/bjd/ljaf085.334
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.202BI34 Scleromyxoedema in pregnancy: a rare and complex case妊娠合并硬化性粘液水肿：一例罕见复杂病例DOI: 10.1093/bjd/ljaf085.443
Curēus IF: 01.300Volume 17, Issue 11No.203Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitors and Risk of Heart Failure Hospitalization in Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials钠-葡萄糖协同转运蛋白-2抑制剂与2型糖尿病患者心衰住院风险：一项随机对照试验的系统回顾与荟萃分析DOI: 10.7759/cureus.96456
bioRxivVolume 2025, Issue No.204Disease-associated mutations in the STAT5B SH2 domain reprogram hepatic cholesterol and lipid metabolism疾病相关的STAT5B SH2结构域突变重编程肝脏胆固醇和脂质代谢DOI: 10.1101/2025.11.27.691004
In silico pharmacologyVolume 14, Issue 1No.205In vitro and computational evaluation of the erectogenic and anti-diabetic potential of ethanol extract of Hymenodictyon pachyantha stem barkHymenodictyon pachyantha茎皮乙醇提取物在体外和计算层面的勃起及抗糖尿病潜力评估DOI: 10.1007/s40203-025-00510-6
Curēus IF: 01.300Volume 17, Issue 11No.206Unexpected Electroencephalogram Activity in a Brain-Dead Organ Donor: A Case Report一例脑死亡器官捐献者中的意外脑电图活动DOI: 10.7759/cureus.96488
Curēus IF: 01.300Volume 17, Issue 11No.207Determinants of Hypertension Among Transport Workers in Ibadan, Nigeria: A Structural Equation Modeling Approach尼日利亚伊巴丹市运输工人高血压的影响因素：一项结构方程模型方法研究DOI: 10.7759/cureus.96458
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.208Vitamin D supplementation and its impact on leptin and interleukin-6 in women following religious intermittent fasting: a controlled study维生素D补充对遵循宗教间歇性禁食女性瘦素和白介素-6的影响：一项对照研究DOI: 10.3389/fendo.2025.1700844
Caspian J Intern Med IF: 01.000Volume 16, Issue 4No.209Association between osteoporosis and symptomatic knee osteoarthritis in postmenopausal women: A case-control study绝经后女性骨质疏松与症状性膝骨关节炎的关联：一项病例对照研究DOI: 10.22088/cjim.16.4.686
bioRxivVolume 2025, Issue No.210Hepatocyte MLKL Drives Obesity-Driven Hepatocellular Carcinoma Progression via Mitochondrial Dysfunction Independent of Necroptosis in MASLD肝细胞MLKL通过不依赖坏死性凋亡的线粒体功能障碍驱动肥胖相关的代谢功能障碍相关脂肪性肝病性肝细胞癌进展DOI: 10.1101/2025.11.26.690789
Frontiers in pediatrics IF: 02.000Volume 13, Issue No.211Influence of gestational history on neural tube defects and Eisenmenger syndrome: associations with intellectual disability and visual impairment in children and adults - a systematic review妊娠史对神经管缺陷和艾森曼格综合征的影响：与儿童及成人智力障碍和视力障碍的关联——一项系统综述DOI: 10.3389/fped.2025.1522839
Clinical case reports IF: 00.600Volume 13, Issue 12No.212Comorbidity of Attention Deficit Hyperactivity Disorder (ADHD) and Chung-Jansen Syndrome: Case Report and Review of Literature注意缺陷多动障碍与钟-詹森综合征共病：病例报告及文献回顾DOI: 10.1002/ccr3.71593
Frontiers in nutrition IF: 05.100Volume 12, Issue No.213Weight loss increases circadian gene expression and emotional well-being in individuals with obesity减重可提升肥胖患者的昼夜节律基因表达和情绪健康水平DOI: 10.3389/fnut.2025.1722428
Frontiers in nutrition IF: 05.100Volume 12, Issue No.214The impact of high fructose corn syrup on liver injury and glucose metabolism: a systematic review高果糖玉米糖浆对肝损伤和葡萄糖代谢的影响：一项系统综述DOI: 10.3389/fnut.2025.1724398
Frontiers in public health IF: 03.400Volume 13, Issue No.215Navigating barriers and facilitators to lifestyle changes after bariatric surgery among Emirati adolescents: a qualitative study探索阿联酋青少年减重手术后的生活方式转变：障碍与促进因素的定性研究DOI: 10.3389/fpubh.2025.1702340
Eur J Paediatr Dent IF: 02.700Volume 26, Issue 4No.216SIOI Policy on Sugar Intake: Limiting Free Sugars from Earliest Days of Life to Prevent Caries, Specific Non-Communicable Diseases, and Tumors意大利儿科牙科学会（SIOI）关于糖摄入的政策：限制生命早期及终生的游离糖以预防龋齿、特定非传染性疾病与肿瘤DOI: 10.23804/ejpd.2025.26.04.02
The Journal of asthma IF: 01.300Ahead of Print.No.217Mediterranean Diet Adherence and Its Association with Inflammatory and Oxidative Stress Biomarkers in Asthma地中海饮食依从性及其与哮喘患者炎症和氧化应激生物标志物的关联DOI: 10.1080/02770903.2025.2592243
J Health Soc Behav IF: 03.600Ahead of Print.No.218Low-Density Zoning and Health Disparities in Metro Areas低密度分区与都市区健康差异DOI: 10.1177/00221465251391834
Rom J Morphol Embryol IF: 01.500Volume 66, Issue 3No.219An exploratory study on the impact of endocrine and infectious comorbidities on reproductive outcomes after Palmer-type neosalpingostomy关于内分泌及感染性共病对Palmer型输卵管再造术后生殖结局影响的探索性研究DOI: 10.47162/RJME.66.3.10
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.220P050 Impact of weight-loss interventions on psoriasis severity: a systematic review and meta-analysis减肥干预对银屑病严重程度的影响：一项系统回顾与荟萃分析DOI: 10.1093/bjd/ljaf085.078
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.221PD01 Liver fibroscanning identifies hepatic fibrosis at an early stage in erythropoietic protoporphyria: a new analysis in 132 patients肝纤维化扫描在132例红细胞生成性原卟啉病患者中早期识别肝纤维化：一项新的分析DOI: 10.1093/bjd/ljaf085.253
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.222SG15 Unravelling the risk factors for hidradenitis suppurativa: a genetic approachSG15 揭示化脓性汗腺炎的风险因素：一项遗传学方法DOI: 10.1093/bjd/ljaf085.524
British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.223P101 Janus kinase inhibitors in palmoplantar pustulosis: a systematic review and meta-analysis of comorbidity burden to inform a feasibility trial's design (JAKPPPOT)Janus激酶抑制剂治疗掌跖脓疱病：一项针对共病负担的系统综述与荟萃分析，为可行性试验设计提供信息 (JAKPPPOT)DOI: 10.1093/bjd/ljaf085.129
BMC infectious diseases IF: 03.000Ahead of Print.No.224Effectiveness comparison of nirmatrelvir/ritonavir versus molnupiravir in COVID-19 patients with comorbidities in Taiwan: a multi-centre electronic health record study台湾COVID-19共病症患者中奈玛特韦/利托那韦与莫诺拉韦有效性比较：一项多中心电子健康记录研究DOI: 10.1186/s12879-025-12316-0
BMC surgery IF: 01.800Ahead of Print.No.225Predictors of acute gangrenous cholecystitis and its complications: a retrospective cohort study急性坏疽性胆囊炎及其并发症的预测因素：一项回顾性队列研究DOI: 10.1186/s12893-025-03356-z
BMC public health IF: 03.600Ahead of Print.No.226The relationship of the nutritional literacy level of individuals with diabetes on nutrition, quality of life, and metabolic control糖尿病患者的营养素养水平与其营养、生活质量和代谢控制的关系DOI: 10.1186/s12889-025-25948-3
BMC public health IF: 03.600Ahead of Print.No.227Promoting physical activity at Danish schools targeting youth who are not in employment, education or training (NEET): a qualitative study促进丹麦学校中针对未就业、未受教育或未接受培训（NEET）青年的体力活动：一项定性研究DOI: 10.1186/s12889-025-25879-z
BMC public health IF: 03.600Ahead of Print.No.228Global prevalence of multimorbidity among people living with type 2 diabetes: a systematic review and meta-analysis全球2型糖尿病患者中多病共患的患病率：一项系统综述和荟萃分析DOI: 10.1186/s12889-025-25570-3
Annals of surgical oncology IF: 03.500Ahead of Print.No.229ASO Author Reflections: Can Targeted Nutrition Level the Playing Field? Reflections on Preoperative Support for Malnourished Colorectal Cancer Patients in ERASASO作者述评：靶向营养支持能否改善公平性？——ERAS中营养不良结直肠癌患者术前支持的反思DOI: 10.1245/s10434-025-18832-2
Nature reviews. Endocrinology IF: 40.000Ahead of Print.No.230The hidden health effects of endocrine-disrupting chemicals内分泌干扰化学物质的隐匿健康效应DOI: 10.1038/s41574-025-01222-9
Nature communications IF: 15.700Ahead of Print.No.231Hepatic metabolic reprogramming in male mice during short-term caloric restriction involves enhanced glucocorticoid rhythms短期热量限制期间雄性小鼠的肝脏代谢重编程涉及增强的糖皮质激素节律DOI: 10.1038/s41467-025-67228-z
Nature communications IF: 15.700Ahead of Print.No.232In vivo base editing rescues ADPKD in a humanized mouse model体内碱基编辑在⼈源化⼩⿏模型中挽救ADPKDDOI: 10.1038/s41467-025-65997-1
J Cell Mol Med IF: 04.200Volume 29, Issue 23No.233Investigation of the Characteristics of Telomere Length in Koreans and Its Association With Chronic Metabolic Disorders: A Comprehensive Study韩国人端粒长度特征及其与慢性代谢性疾病关联的综合研究DOI: 10.1111/jcmm.70964
Primary care diabetes IF: 02.300Ahead of Print.No.234The U.S. diabetes belt and factors explaining the excess risk: Multifactorial modeling and machine learning analysis美国糖尿病带及其超额风险因素：多因素建模与机器学习分析DOI: 10.1016/j.pcd.2025.12.001
Clinics in shoulder and elbow IF: 01.700Ahead of Print.No.235Factors associated with shoulder function following ultrasound-guided hydrodilatation in patients with frozen shoulder: a prospective observational study冻结肩患者超声引导下液压扩张术后肩关节功能的相关因素：一项前瞻性观察研究DOI: 10.5397/cise.2025.00773
J Prev Med Public Health IF: 02.100Ahead of Print.No.236Feasibility and Preliminary Impacts of a Diabetes Education Chatbot Simulation on Glycemic Targets, Loneliness, and Health Beliefs: An Explanatory Mixed-methods Study一项解释性混合方法研究：糖尿病教育聊天机器人模拟的可行性与对血糖目标、孤独感及健康信念的初步影响DOI: 10.3961/jpmph.25.334
Epidemiology and health IF: 02.200Ahead of Print.No.237Dental implant removal rates and related factors in older adults in South Korea: a cross-sectional study using National Health Insurance Sharing Service Data韩国老年人种植牙移除率及相关因素分析：一项基于国民健康保险公团数据的横断面研究DOI: 10.4178/epih.e2025064
Epidemiology and health IF: 02.200Ahead of Print.No.238Cardiovascular Disease Risk Disparities between Immigrants and Native Koreans: A Population-Based Study in Gwangju, South Korea韩国光州的一项基于人群研究：移民与本土韩国人的心血管疾病风险差异DOI: 10.4178/epih.e2025067
Acta biomaterialia IF: 09.600Ahead of Print.No.239Engineered Cerium Oxide Nanoparticles Conjugated with Carrier Platforms: Therapeutic Mechanisms for Skin Wound Healing Applications工程化二氧化铈纳米颗粒偶联载体平台：用于皮肤伤口愈合应用的治疗机制DOI: 10.1016/j.actbio.2025.12.016
Practical radiation oncology IF: 03.500Ahead of Print.No.240Surgical Reconstruction Toxicity Following Hypofractionated Adjuvant Radiotherapy for Primary Cutaneous Melanoma原发性皮肤黑色素瘤大分割辅助放疗后的手术重建毒性研究DOI: 10.1016/j.prro.2025.11.004
Food and chemical toxicology IF: 03.500Ahead of Print.No.241Differential Effects on Acetaminophen-induced Nephrotoxicity and Liver Injury Following Modulation of Glutathione Resynthesis谷胱甘肽再合成调控对乙酰氨基酚诱导的肾毒性和肝损伤的差异效应DOI: 10.1016/j.fct.2025.115896
Experimental neurology IF: 04.200Ahead of Print.No.242Azeliragon attenuates cerebral infarction aggravation in diabetic rats: Receptor for advanced glycation end-product as a novel therapeutic target阿折拉贡减轻糖尿病大鼠脑梗死加重：晚期糖基化终末产物受体作为新型治疗靶点DOI: 10.1016/j.expneurol.2025.115588
Cell communication and signaling IF: 08.900Ahead of Print.No.243Phosphoproteomics unveils the signaling dynamics in neuronal cells stimulated with insulin and insulin-like growth factors磷酸化蛋白质组学揭示胰岛素和胰岛素样生长因子刺激神经元细胞的信号动态DOI: 10.1186/s12964-025-02573-6
Nature communications IF: 15.700Ahead of Print.No.244Imbalance of stem-like and effector T cell states in children with early type 1 diabetes across conventional and regulatory subsets儿童早期1型糖尿病中常规与调节性T细胞亚群内干细胞样与效应状态的失衡DOI: 10.1038/s41467-025-66459-4
Nature communications IF: 15.700Ahead of Print.No.2453D imaging of human pancreas suggests islet size and endocrine composition influence their loss in type 1 diabetes三维成像揭示人胰腺胰岛大小和内分泌组成影响其在1型糖尿病中的丢失DOI: 10.1038/s41467-025-66198-6
Nature communications IF: 15.700Ahead of Print.No.246Body-wide synchronization of insulin-signaling dependent DAF-16/FOXO nuclear translocation pulses correlated with C. elegans growth依赖胰岛素信号的DAF-16/FOXO核转位脉冲呈现全身同步化并与秀丽隐杆线虫的生长相关DOI: 10.1038/s41467-025-66164-2
Nature communications IF: 15.700Ahead of Print.No.247Proximity labeling of DAF-16 FOXO highlights aging regulatory proteinsDAF-16 FOXO的邻近标记揭示衰老调控蛋白质DOI: 10.1038/s41467-025-66409-0
Wiadomo?ci ParazytologiczneVolume 71, Issue No.248Detection of Serpentoplasma sp. (Apicomplexa: Haemohormidiidae) in dice snake (Natrix tesellata) (Colubridae: Natrix) in Azerbaijan在阿塞拜疆棋斑水蛇（Natrix tessellata）中检测到Serpentoplasma sp.（顶复门：血激素虫科）DOI: 10.17420/ap71.553
J Biol Chem IF: 03.900Ahead of Print.No.249KANK1 regulates the positioning of liprin-α1 and the spatial organisation of insulin granule fusion in pancreatic β cellsKANK1调控liprin-α1的定位及胰腺β细胞中胰岛素颗粒融合的空间组织DOI: 10.1016/j.jbc.2025.111036
Comput Biol Chem IF: 03.100Ahead of Print.No.250Apigenin potentiates glucose stimulated insulin secretion: A mechanistic insight into the mode of activation of PKA芹菜素增强葡萄糖刺激的胰岛素分泌：对蛋白激酶A激活机制的深入解析DOI: 10.1016/j.compbiolchem.2025.108796
Diabetes & metabolic syndrome IF: 03.400Ahead of Print.No.251The effects of low carbohydrate and high protein diet on the anthropometric indices, blood pressure, metabolic factors, and hormones related to metabolism: A systematic review and meta-analysis低碳水化合物高蛋白饮食对人体测量学指标、血压、代谢因素及代谢相关激素影响的系统综述与荟萃分析DOI: 10.1016/j.dsx.2025.103352
Scientific reports IF: 03.900Ahead of Print.No.252Integrative severity scale for diabetic macular atrophy and ischemia using structural OCT and OCT angiography采用结构OCT和OCTA的糖尿病性黄斑萎缩与缺血的综合严重程度分级DOI: 10.1038/s41598-025-31862-w
J Health Popul Nutr IF: 02.800Ahead of Print.No.253Age- and sex-specific reference values for plasma lipids and lipoproteins in thai adults: a national health examination survey analysis泰国成人血浆脂质与脂蛋白年龄-性别特异性参考值：一项全国健康调查分析DOI: 10.1186/s41043-025-01176-8
BMJ open IF: 02.300Volume 15, Issue 12No.254Associations of functional foods consumption with gastrointestinal and musculoskeletal conditions: a cross-sectional study among Bangladeshi adults功能性食品消费与胃肠道及肌肉骨骼疾病的关联性：一项孟加拉国成年人的横断面研究DOI: 10.1136/bmjopen-2025-103593
Scientific reports IF: 03.900Ahead of Print.No.255Efficacy and safety of pioglitazone versus dapagliflozin as an add-on to metformin and alogliptin combination therapy: the EPIDOTE study吡格列酮对比达格列净作为二甲双胍和阿格列汀联合治疗的添加治疗的有效性和安全性：EPIDOTE研究DOI: 10.1038/s41598-025-30882-w
Updates in surgery IF: 02.200Ahead of Print.No.256Commentary on "Unappreciated, undervalued, and working in a toxic environment: the silent struggles of some surgeons"评论“不受赏识、价值被低估，并在有毒环境中工作：一些外科医生的默默挣扎”DOI: 10.1007/s13304-025-02488-4
International journal of obesity IF: 03.800Ahead of Print.No.257Preoperative 24-hour movement behaviors and early weight loss after metabolic bariatric surgery: a compositional analysis术前24小时运动行为与代谢性减重手术后早期体重减轻：一项成分分析DOI: 10.1038/s41366-025-01983-3
Surgical endoscopy IF: 02.700Ahead of Print.No.258Special findings in high-resolution manometry prior to metabolic surgery: obesity as a risk factor for esophagogastric junction outflow obstruction or achalasia?代谢手术前高分辨率测压的特殊发现：肥胖是食管胃结合部流出道梗阻或贲门失弛缓症的危险因素？DOI: 10.1007/s00464-025-12472-z
Pediatric research IF: 03.100Ahead of Print.No.259Relationship between serum lipids/adipokines and obesity/hypertension in very-preterm infants during early childhood and preadolescence极早产儿在幼儿期和青春期前血清脂质/脂肪因子与肥胖/高血压的关系DOI: 10.1038/s41390-025-04578-w
Nature medicine IF: 50.000Ahead of Print.No.260Implementation and effectiveness of a care process to prioritize weight management in primary care: a stepped-wedge cluster-randomized trial初级保健中优先体重管理的护理流程的实施与效果：一项阶梯式楔形整群随机试验DOI: 10.1038/s41591-025-04051-5
Scientific reports IF: 03.900Volume 15, Issue 1No.261Pharmacological and toxicological insights into the ayurvedic formulation Rasasindura阿育吠陀制剂Rasasindura的药理学与毒理学见解DOI: 10.1038/s41598-025-97062-8
J Hum Nutr Diet IF: 02.500Volume 38, Issue 6No.262The Efficacy and Safety of a Preoperative Dietitian-Led Very Low Calorie Diet Clinic for Adults With Obesity for Colorectal Cancer Surgery: A Retrospective Cohort Study营养师主导的术前极低热量饮食门诊对计划接受结直肠癌手术的肥胖成年人的有效性与安全性：一项回顾性队列研究DOI: 10.1111/jhn.70178
Am J Clin Nutr IF: 06.900Ahead of Print.No.263Dietary fats, blood lipids and atherosclerotic cardiovascular disease: time for food-based approach?膳食脂肪、血脂与动脉粥样硬化性心血管疾病：食物导向策略的时机？DOI: 10.1016/j.ajcnut.2025.11.007
Obes Res Clin Pract IF: 02.300Ahead of Print.No.264Development and early evaluation of OPTIMAP: A digitally enabled nurse-led multidisciplinary pathway for care of people with severe obesity in a Public Australian Health NetworkOPTIMAP：在澳大利亚一公共医疗网络中，为严重肥胖患者开发的数字赋能护士主导多学科护理路径及其早期评估DOI: 10.1016/j.orcp.2025.12.004
Obes Res Clin Pract IF: 02.300Ahead of Print.No.265Vitamin D, adiposity, and cardiometabolic risk: Insights from a multivariable cross-sectional study维生素D、肥胖与心脏代谢风险：来自一项多变量横断面研究的启示DOI: 10.1016/j.orcp.2025.12.005
Surg Obes Relat Dis IF: 03.800Ahead of Print.No.266Impact of preoperative and postoperative anti-obesity medications on early postoperative body mass index reduction after sleeve gastrectomy in pediatrics袖状胃切除术前和术后使用抗肥胖药物对儿科患者早期术后体重指数减少的影响DOI: 10.1016/j.soard.2025.10.019
Expert opinion on drug discovery IF: 04.900Ahead of Print.No.267Advancing obesity treatments through innovations in the design and manufacturing of therapeutic peptides通过治疗性肽的设计与制造创新推进肥胖治疗DOI: 10.1080/17460441.2025.2601113
Pediatric obesity IF: 02.700Volume 21, Issue 1No.268Acute Exercise-Induced Energy Expenditure and Substrate Oxidation Rates Might Not Be Associated With Subsequent Appetitive Responses in Adolescents Living With Obesity急性运动诱导的能量消耗与底物氧化率可能与肥胖青少年随后的食欲反应无关DOI: 10.1111/ijpo.70073
Epidemiology and health IF: 02.200Ahead of Print.No.269The discriminatory ability of the body roundness index and body mass index for metabolic diseases in Korean adults: a comparative study身体圆度指数与身体质量指数对韩国成年人群代谢疾病的判别能力：一项比较研究DOI: 10.4178/epih.e2025069
Physiology & behavior IF: 02.500Ahead of Print.No.270The combination of physical activity and late-time-restricted eating improves eating behavior, cognitive performance and cardiovascular parameters in women living with excess body weight体力活动与晚间限时饮食相结合可改善超重女性的饮食行为、认知表现和心血管参数DOI: 10.1016/j.physbeh.2025.115200
Appetite IF: 03.800Ahead of Print.No.271No heightened temporal attentional bias towards food or overweight bodies in adolescents with obesity青少年肥胖患者对食物或超重身体不存在更强的时间性注意偏倚DOI: 10.1016/j.appet.2025.108417
Molecular metabolism IF: 06.600Ahead of Print.No.272The Innate Thermogenic Capacity of Brown Adipose Tissue Develops Independently of Sympathetic Signaling棕色脂肪组织的先天产热能力独立于交感神经信号而发育DOI: 10.1016/j.molmet.2025.102299
Brain & development IF: 01.300Ahead of Print.No.273Brain health in youth - what are we measuring? - A comprehensive review青少年脑健康——我们测量的是什么？一项全面综述DOI: 10.1016/j.braindev.2025.104491
Science of the total environment IF: 08.000Ahead of Print.No.274Ethylparaben and consumer chemicals and their associations with metabolic disorders: A multicycle analysis of Korean National Environmental Health Survey (2015-2020)乙基对羟基苯甲酸酯及消费品化学物质与代谢紊乱的关联：基于韩国国家环境健康调查（2015-2020）的多周期分析DOI: 10.1016/j.scitotenv.2025.181128
Nutrition IF: 03.000Ahead of Print.No.275Evaluation of obesity phenotypes from childhood to adolescence: Does diet quality in childhood matter? (PASE Study-Brazil)从儿童期到青少年期肥胖表型评估：儿童期饮食质量重要吗？（巴西PASE研究）DOI: 10.1016/j.nut.2025.113027
Phytomedicine IF: 08.300Ahead of Print.No.276Anti-adipogenic effect of cryptotanshinone in 3T3-L1 preadipocytes via binding to glucagon-like peptide 1 receptor and its signaling隐丹参酮通过结合胰高血糖素样肽1受体及其信号通路在3T3-L1前脂肪细胞中发挥抗脂肪生成作用DOI: 10.1016/j.phymed.2025.157666
J Trace Elem Med Biol IF: 03.300Ahead of Print.No.277Association between serum chromium and nickel levels with metabolic markers and HOMA-β in overweight and obese adults超重及肥胖成年人的血清铬、镍水平与代谢标志物及HOMA-β的关联性研究DOI: 10.1016/j.jtemb.2025.127803
Gynecologic oncology IF: 04.100Ahead of Print.No.278Associations between obesity and outcomes in pembrolizumab-treated endometrial cancer帕博利珠单抗治疗的子宫内膜癌患者中肥胖与预后之间的关联DOI: 10.1016/j.ygyno.2025.12.001
Epilepsy & behavior IF: 02.300Ahead of Print.No.279Health risk factors and polypharmacy in people with epilepsy and their association with multimorbidity: a single centre retrospective study癫痫患者的健康风险因素与多药治疗及其与共病的关联：一项单中心回顾性研究DOI: 10.1016/j.yebeh.2025.110829
Cardiovasc Diabetol Endocrinol RepVolume 11, Issue 1No.280Chronic hyperglycemia and cardiovascular dysfunction: an in-depth exploration of metabolic and cellular pathways in type 2 diabetes mellitus慢性高血糖与心血管功能障碍：深入探索2型糖尿病的代谢与细胞通路DOI: 10.1186/s40842-025-00247-3
BMC Cardiovascular Disorders IF: 02.300Ahead of Print.No.281Association between atherogenic index of plasma and various metabolic conditions: an umbrella review on meta-analyses血浆致动脉粥样硬化指数与多种代谢状况的关联：一项关于Meta分析的伞状评价DOI: 10.1186/s12872-025-05409-w
Scientific reports IF: 03.900Ahead of Print.No.282Association of glycemic variability with oxidative stress and AGE accumulation in type 2 diabetes2型糖尿病中血糖变异性与氧化应激及AGE积累的关联DOI: 10.1038/s41598-025-31845-x
BMC Complement Med Ther IF: 03.400Ahead of Print.No.283GB5, a synergistic phytotherapy for type 2 diabetes mellitus management: an integrated polyherbal approach from phytochemical profiling to network pharmacologyGB5：一种用于管理2型糖尿病的协同植物疗法——从植物化学分析到网络药理学的综合复方草药方法DOI: 10.1186/s12906-025-05192-3
Journal of clinical apheresis IF: 02.700Volume 40, Issue 6No.284A Simplified Scoring System to Predict In-Hospital Mortality of Leukapheresis in Patients With Leukemia用于预测白血病患者白细胞分离术住院死亡率的简化评分系统DOI: 10.1002/jca.70078
Sleep & breathing IF: 02.000Volume 30, Issue 1No.285The impact of sleep disturbances in individuals with comorbid diabetes and chronic kidney disease: a systematic review睡眠障碍对合并糖尿病与慢性肾脏病个体健康影响：一项系统综述DOI: 10.1007/s11325-025-03552-4
J Infect Public Health IF: 04.000Ahead of Print.No.286The impact of sodium-glucose co-transporter 2 inhibitors on the incidence of non-tuberculous mycobacteria infection in diabetes populations钠-葡萄糖协同转运蛋白2抑制剂对糖尿病人群非结核分枝杆菌感染发生率的影响DOI: 10.1016/j.jiph.2025.103089
European journal of pediatrics IF: 02.600Volume 185, Issue 1No.287Early kidney damage in children and adolescents with primary arterial hypertension: a systematic review儿童和青少年原发性动脉高血压的早期肾脏损伤：一项系统综述DOI: 10.1007/s00431-025-06671-y
283
Diabetes Mellitus(DM)
糖尿病
127
Obesity
肥胖症
75
Insulin
胰岛素
25
Type 2 diabetes mellitus(T2DM)
2型糖尿病
16
Metformin
二甲双胍
15
Metabolic Syndrome
代谢综合征
11
Diabetic Kidney Disease(DKD)
糖尿病肾脏病
11
Diabetic Retinopathy
糖尿病视网膜病
9
Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA)
胰高血糖素样肽-1受体激动剂
8
Hypoglycemic Agents
降糖药
8
Gestational Diabetes Mellitus(GDM)
妊娠糖尿病
7
Semaglutide
司美格鲁肽
7
Dapagliflozin
达格列净
6
Diabetic Foot
糖尿病足
6
Type 1 diabetes mellitus(T1DM)
1型糖尿病
5
Diabetic Neuropathies
糖尿病性神经病变
4
Liraglutide
利拉鲁肽
3
Gabapentin
加巴喷丁
3
Pregabalin
普瑞巴林
3
Empagliflozin
恩格列净
3
Diabetes Complications
糖尿病并发症
2
Canagliflozin
卡格列净
2
Sotagliflozin
索格列净
2
gamma-Aminobutyric Acid(GABA)
γ-氨基丁酸
2
Tirzepatide
替尔泊肽
2
Dulaglutide
度拉糖肽
2
Dipeptidyl-Peptidase IV Inhibitors(DPP-4i)
二肽基肽酶-4抑制剂
1
Vildagliptin
维格列汀
1
Alogliptin
阿格列汀
1
Exenatide
艾塞那肽
1
Gastrointestinal lipase inhibitor
胃肠道脂肪酶抑制剂
1
Orlistat
奥利司他
1
Diabetic acidosis
糖尿病性酸中毒
1
Diabetic Cardiomyopathies
糖尿病心肌病
1
Ertugliflozin
艾托格列净
1
Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i)
钠-葡萄糖协同转运蛋白2抑制剂
编辑：丁克芳
审校：丁克芳
2025-12-12
·百度百家
【 莫那比拉韦的批准与适用 】
英国药品与保健品管理局于4日宣布，美国默克公司研发的口服抗新冠药物莫那比拉韦已获得批准，适用于特定类型的新冠患者。这标志着全球首款抗新冠口服药物的诞生。据公告显示，该药物适用于有轻度至中度症状的新冠患者，特别是那些存在至少一个重症风险因素的患者，如肥胖、年龄超过60岁、糖尿病和心脏病等。
【 药物研发背景与临床试验 】
莫那比拉韦是由默克公司和美国里奇巴克生物医药公司共同研发的，它是一种针对RNA病毒的小分子广谱抗病毒口服药，能够抑制新冠病毒的复制。根据默克公司10月初发布的Ⅲ期临床试验中期分析数据，该药物能显著降低轻度至中度症状新冠患者的住院或死亡风险，降幅高达约50%。
【 全球影响与未来审批进程 】
在英国药品与保健品管理局的公告中，特别提到了英国的独立专家顾问组“人用药品委员会”对莫那比拉韦的安全性、质量和有效性进行了详尽的审查。这一审查过程确保了该药物能够成为全球首款获批治疗新冠感染的口服抗病毒药物。此外，英国卫生大臣赛义德·贾维德强调，对于那些最脆弱和免疫抑制的患者来说，这款药物的批准将带来“游戏规则的改变”，他们将能够迅速接受到突破性的治疗。值得注意的是，英国是全球首个正式批准使用莫那比拉韦治疗新冠患者的国家。欧洲药品管理局也已表示，将在10月5日之后考虑启动对该药物的快速审批程序。同时，默克公司也已向美国食品和药物管理局提交了该药物的紧急使用授权申请。
临床3期
2025-12-04
Journal of Antimicrobial Chemotherapy Volume 80, Issue 7抗菌化疗杂志 80卷 7期
https://academic.oup.com/jac/issue
REVIEWS（综述）
1
The role of antimicrobial prophylaxis in brachytherapy for prostate, breast and gynaecological cancer: a narrative review
抗生素预防用药在前列腺、乳腺及妇科癌症近距离治疗中的作用：叙述性综述
Konstantinos Alexakis and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 1753–1771,
2
To be or not to be: the non-antimicrobial properties of common antimicrobials
生存还是毁灭：常见抗菌药物的非抗菌特性
Shivakumar Narayanan and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 1772–1783,
SYSTEMATIC REVIEWS（系统综述）
3
Antibiotic-induced Bartter-like syndrome: a systematic review
抗生素诱发的巴特综合征样表现：系统综述
Megha Priyadarshi and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 1784–1791,
4
Liposomal amphotericin B prophylaxis in paediatrics: a systematic review
两性霉素B脂质体预防性用药在儿科中的应用：系统综述
Emma V Thorley and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 1792–1802,
ORIGINAL RESEARCH（论著）
5
Antibiotic use attributable to RSV infections during infancy—an international prospective birth cohort study
婴儿期呼吸道合胞病毒感染所致抗生素使用情况——一项国际前瞻性出生队列研究
Sarah F Hak and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 1803–1812,
6
Plasmodium falciparum isolates: ex vivo drug response
恶性疟原虫分离株：体外药物反应
Edem Adika and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 1813–1822,
7
Impact of hypoalbuminemia on patients receiving ertapenem combination therapy for methicillin-susceptible Staphylococcus aureus bacteraemia
低白蛋白血症对接受厄他培南联合疗法治疗甲氧西林敏感金黄色葡萄球菌菌血症患者的影响
Sunish Shah and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 1823–1827,
8
Exploring community pharmacy professionals and general practitioners’ views on primary care communication and pathways to access antibiotics in England
探究英国社区药房专业人员和全科医生对初级保健沟通及获取抗生素途径的看法
Ming Xuan Lee and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 1828–1836,
9
Decline of antimicrobial resistance in Pseudomonas aeruginosa bacteraemia following the COVID-19 pandemic: a longitudinal observational study
新冠疫情后铜绿假单胞菌菌血症抗菌药物耐药性的下降：一项纵向观察研究
Yulia Butscheid and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 1837–1848,
10
Selected comorbidities and the probability of ART switch in PWH with undetectable HIV-RNA: a retrospective analysis in Italy
意大利HIV感染者（HIV-RNA不可检测）特定合并症与抗逆转录病毒药物转换概率：一项回顾性分析
Alessandro Cozzi-Lepri and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 1849–1859,
11
Model-based translation of the PKPD-relationship for linezolid and vancomycin on methicillin-resistant Staphylococcus aureus: from in vitro time–kill experiments to a mouse pneumonia model
基于模型转化利奈唑胺和万古霉素对甲氧西林耐药金黄色葡萄球菌的药代动力学-药效学关系：从体外时间杀菌实验到小鼠肺炎模型
Diego Vera-Yunca and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 1860–1868,
12
Inner-mitochondrial membrane protein PfMPV17 is linked to P. falciparum in vitro resistance to the indoloquinolizidine alkaloid alstonine
线粒体内膜蛋白PfMPV17与恶性疟原虫对吲哚醌啉生物碱阿尔斯通宁的体外耐药性相关
J R Macdonald and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 1869–1877,
13
Efficacy and tolerability of the combination of minocycline and metronidazole for macrolide-resistant Mycoplasma genitalium
米诺环素与甲硝唑联合治疗大环内酯类耐药生殖支原体感染的疗效和耐受性
Kay Htaik and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 1878–1884,
14
Early use of the novel antifungal rezafungin: a case series and literature review
新型抗真菌药物瑞扎芬净的早期使用：病例系列报道及文献综述
H C Davidson and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 1885–1892,
15
Optimal dosing of amoxicillin in obese and post-gastric bypass patients using a population pharmacokinetics-pharmacodynamics model approach
基于群体药代动力学-药效学模型方法确定阿莫西林在肥胖和胃旁路术后患者中的最佳剂量
Gisela Myrian de Lima Leite Dalla Rosa and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 1893–1901,
16
Decreasing antimicrobial resistance in representative UK livestock species was associated with reduced total sales of antimicrobials in the last decade
过去十年，英国代表性家畜物种抗菌药物耐药性下降与抗菌药物总销量减少相关
Aliya El Nagar and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 1902–1906,
17
An improved multiplex RT–quantitative PCR assay can reveal sex-specific activity of transmission-blocking drugs on ex vivo gametocytes from Plasmodium falciparum asymptomatic infections
一种改进的多重逆转录定量聚合酶链反应检测法可揭示性特异性抗疟疾传播阻断药物对恶性疟原虫无症状感染体外配子体活性的影响
Mariagrazia Ciardo and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 1907–1914,
18
Population pharmacokinetics and thrombocytopenia risk assessment of linezolid in liver transplant recipients
利奈唑胺在肝移植受者中的群体药代动力学及血小板减少症风险评估
Xiaoping Shi and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 1915–1925,
19
Rapid susceptibility testing on urine for antimicrobial stewardship in general practice
全科实践中的尿液快速药敏试验助力抗菌药物管理
Patrick D J Sturm and Tanja Schülin
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 1926–1932,
20
Efficacy of linezolid in monotherapy q12h versus q8h versus combined with daptomycin in the treatment of experimental endocarditis caused by methicillin-resistant and glycopeptide-intermediate Staphylococcus aureus strains
利奈唑胺单药治疗每12小时一次与每8小时一次，以及与达托霉素联合治疗甲氧西林耐药和糖肽中介金黄色葡萄球菌菌株所致实验性心内膜炎的疗效
María-Alexandra Cañas and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 1933–1941,
21
In vitro activity of NOSO-502, a novel-action antimicrobial, against clinical strains of Enterobacterales including MDR strains
新型作用机制抗菌药物NOSO-502对包括多重耐药菌株在内的肠杆菌科临床菌株的体外活性
Marie L G Attwood and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 1942–1946,
22
Antibacterial activity of propylene glycol against Staphylococcus aureus and Staphylococcus epidermidis in neutral and mild acidic conditions
中性及弱酸性条件下，丙二醇对金黄色葡萄球菌和表皮葡萄球菌的抗菌活性
Nadiia Mosiichuk and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 1947–1950,
23
Molecular characteristics of chromosome-mediated colistin resistance in foodborne Salmonella isolates in China
中国食源性沙门氏菌分离株染色体介导的多粘菌素耐药性的分子特征
Zeqiang Zhan and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 1951–1963,
24
High azole non-wild type rates and nosocomial microsatellite typing aggregation of Wickerhamomyces anomalus in China according to a 12-year multicenter surveillance study
根据一项为期12年的多中心监测研究，中国异常威克汉姆酵母属唑类非野生型率高且医院内微卫星分型聚集
Zhengyu Luo and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 1964–1971,
25
Repurposing antimalarials: pyrimethamine exhibits superior in vitro activity to metronidazole against Gardnerella while sparing Lactobacillus
抗疟药物再利用：乙胺嘧啶对加德纳菌的体外活性优于甲硝唑，且对乳酸杆菌无影响
Aliona S Rosca and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 1972–1979,
26
Clinical characteristics and risk factors of tigecycline-induced acute pancreatitis in kidney transplant recipients: a retrospective study
肾移植受者替加环素诱发急性胰腺炎的临床特征及危险因素：一项回顾性研究
Lijuan Feng and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 1980–1987,
27
Genomic characteristics of the multiresistant Acinetobacter baumannii global clone 1 reference strain A297/RUH875
多重耐药鲍曼不动杆菌全球克隆1型参考菌株A297/RUH875的基因组特征
Jonathan Koong and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 1988–1992,
28
Comparison of a modified broth microdilution Sensititre™ SLOMYCOI assay with the CLSI-recommended agar disk elution method for antimicrobial susceptibility testing of Mycobacterium haemophilum
改良肉汤微量稀释Sensititre™ SLOMYCOI检测法与CLSI推荐的琼脂稀释法对嗜血杆菌属抗菌药物敏感性检测的比较
Doris Hillemann and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 1993–1996,
29
Reversal of phenotypic resistance in multi-drug resistant carbapenemase-producing K. pneumoniae clinical isolates due to in vitro synergistic interactions between bacteriophages and antibiotics at clinically achievable concentrations
由于细菌噬菌体和抗生素在临床可达到浓度下的体外协同作用，多重耐药碳青霉烯酶产生肺炎克雷伯菌临床分离株的表型耐药性发生逆转
Paschalis Paranos and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 1997–2006,
30
Antibiotic resistance and population structure of Staphylococcus epidermidis from prosthetic joint infections in Sweden and France
瑞典和法国假体关节感染表皮葡萄球菌的抗生素耐药性和群体结构
Sofie M Edslev and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 2007–2015,
31
Lines on the line: evaluating the impact of antibiotic lock therapy versus catheter removal in the management of central vascular catheter infections
抗生素锁疗法与导管拔除术治疗中心血管导管感染的影响评估
Nischal Ranganath and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 2016–2024,
32
Real-time FT-IR typing of Klebsiella pneumoniae: a flexible and rapid approach for outbreak detection and infection control
肺炎克雷伯菌实时傅里叶变换红外分型：一种灵活快速的暴发检测和感染控制方法
Ana Beatriz Gonçalves and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 2025–2031,
33
Antibiotic stress affects the secretion and physicochemical features of extracellular vesicles produced by Helicobacter pylori
抗生素压力影响幽门螺杆菌产生的细胞外囊泡的分泌和物理化学特性
Paweł Krzyżek and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 2032–2043,
34
A novel azithromycin resistance mutation in Mycoplasma genitalium induced in vitro
生殖支原体体外诱导产生的新型阿奇霉素耐药突变
Teck-Phui Chua and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 2044–2050,
RESEARCH LETTERS（研究信函）
35
Posaconazole dosing of enteral formulations in infants and young children to achieve therapeutic concentrations
婴儿和幼儿肠内制剂泊沙康唑的给药剂量以达到治疗浓度
Jeffrey Harrington and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 2051–2053,
36
Antimony used as rescue therapy in a kidney transplant recipient unresponsive to liposomal amphotericin B for chronic visceral leishmaniasis
两性霉素B脂质体治疗慢性内脏利什曼病无效的肾移植受者中使用锑剂作为挽救疗法
Natacha Mrozek and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 2053–2056,
37
Is cefazolin an option for treatment of staphylococcal endogenous endophthalmitis?
头孢唑林是否可用于治疗葡萄球菌性内源性眼内炎？
Alexandra Morin and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 2057–2058,
LETTER TO THE EDITOR（致编辑的信）
38
Use of teicoplanin monotherapy for the treatment of enterococcal infective endocarditis: a retrospective and comparative study at a referral centre—a counterpoint
单用替考拉宁治疗肠球菌感染性心内膜炎：一家转诊中心的回顾性和比较研究——反驳观点
Miguel Villamarín and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 7, July 2025, Pages 2059–2060,
Journal of Antimicrobial Chemotherapy Volume 80, Issue 8
抗菌化疗杂志 80卷 8期
https://academic.oup.com/jac/issue
Review(综述)
1
World Health Organisation’s Bacterial Pathogen Priority List (BPPL) 2017 and BPPL 2024 to combat global antimicrobial resistance crisis: ‘challenges and opportunities’
世界卫生组织2017年和2024年用以应对全球抗菌药物耐药性危机的细菌病原体优先名单（BPPL）：“挑战与机遇”
Vazhayil Hari Krishnaprasad and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2061–2069
Original Research(论著)
2
Aztreonam/avibactam activity against Enterobacterales from European medical centres: summary of 5years of surveillance prior to approval for clinical use (2019–2023)
氨曲南/阿维巴坦对欧洲医疗中心肠杆菌科细菌的活性：临床批准前5年（2019-2023年）监测总结
Helio S Sader and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2070–2079
3
High feasibility of salivary therapeutic drug monitoring in linezolid, but lower feasibility in tedizolid: a single-dose study in healthy subjects and a monocentric prospective exploratory study in patients who received linezolid
利奈唑胺唾液治疗药物监测可行性高，但替地唑胺可行性较低：一项健康受试者单剂量研究和一项接受利奈唑胺患者单中心前瞻性探索性研究
Hitoshi Kawasuji and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2080–2091
4
Establishment and validation of downsized hollow-fibre infection model and pharmacokinetics/pharmacodynamics analysis of VAN on Enterococcus faecium
缩小版中空纤维感染模型的建立与验证及万古霉素对粪肠球菌的药代动力学/药效学分析
Yukitaka Hayashi and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2092–2099
5
Four-month clofazimine regimen for susceptible pulmonary TB: a randomized clinical trial
为期4个月的氯法齐明方案治疗敏感型肺结核：一项随机临床试验
Nusrat Shafiq and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2100–2108
6
An ex vivo model to determine transmembrane clearance of antimicrobials during continuous renal replacement therapy
用于确定连续性肾脏替代治疗期间抗菌药物跨膜清除率的体外模型
Cole McGrath and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2109–2116
7
Optimization and improvement of the disc diffusion method for mucoid Pseudomonas aeruginosa
黏液型铜绿假单胞菌纸片扩散法的优化与改进
Aixin Wang and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2117–2125
8
HIV-1 drug resistance among people living with HIV receiving dolutegravir-based anti-retroviral regimens in Uganda: a national laboratory-based survey using remnant viral load samples, 2022
乌干达接受基于多替拉韦抗逆转录病毒方案的HIV感染者中HIV-1耐药性情况：2022年一项基于国家实验室使用剩余病毒载量样本的调查
Christine Watera and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2126–2134
9
Population pharmacokinetics of weight-based compared with fixed dosing of CAP256V2LS, a broadly neutralizing antibody for HIV prevention in women
与固定剂量相比，基于体重给药的CAP256V2LS（一种用于女性HIV预防的广谱中和抗体）群体药代动力学研究
Sharana Mahomed and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2135–2144
10
Gut microbiota and weight gain in people with HIV on integrase inhibitors: a five-year longitudinal study
接受整合酶抑制剂治疗的HIV感染者肠道微生物群与体重增加情况：一项为期五年的纵向研究
Javier García-Abellán and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2145–2157
11
Development of a ribavirin dosing regimen in transplant recipients with chronic hepatitis E virus infection: a population pharmacokinetic and -dynamic model
慢性戊型肝炎病毒感染移植受者利巴韦林给药方案的开发：一项群体药代动力学和药效学模型研究
Midas B Mulder and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2158–2168
12
Effectiveness and predictors of treatment discontinuation of long-acting cabotegravir/rilpivirine in virologically suppressed people with HIV: real-life data from the Icona Cohort
长效卡博特韦/利匹韦林在病毒受抑制的HIV感染者中的治疗中断有效性和预测因素：来自Icona队列的现实数据
Roberta Gagliardini and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2169–2178
13
Five-days-on-two-days-off (FOTO) versus daily bictegravir/emtricitabine/tenofovir alafenamide in virologically suppressed people with HIV: a pilot randomized clinical trial
病毒受抑制的HIV感染者中，5天用药2天停药（FOTO）方案与每日比克替拉韦/恩曲他滨/丙酚替诺福韦方案的对比：一项初步随机临床试验
Hsin-Yun Sun and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2179–2186
14
Reliability of disc diffusion testing and molecular epidemiology of penicillin-susceptible Staphylococcus aureus bacteraemia
青霉素敏感金黄色葡萄球菌菌血症的纸片扩散试验可靠性和分子流行病学研究
Pernilla Kihlberg and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2187–2193
15
Outcomes of ceftriaxone 2g versus 1g daily in hospitalized patients with pneumonia: a nationwide retrospective cohort study
住院肺炎患者每日头孢曲松2克与1克疗效对比：一项全国性回顾性队列研究
Jumpei Taniguchi and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2194–2202
16
Oleanolic acid derivative bardoxolone combats multidrug-resistant Staphylococcus aureus by destroying cell membrane and pyruvate metabolism pathway
齐墩果酸衍生物巴多昔隆通过破坏细胞膜和丙酮酸代谢途径对抗多重耐药金黄色葡萄球菌
Yun-Dan Zheng and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2203–2213
17
Evaluation of amoxicillin and benzylpenicillin therapy in early-onset neonatal sepsis: a pharmacometric external validation and simulation study
阿莫西林和苄青霉素治疗早期新生儿败血症的评估：一项药效计量学外部验证和模拟研究
Tom C Zwart and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2214–2225
18
48Week body composition changes in persons with HIV switching to dolutegravir plus lamivudine: a planned subanalysis of the DOLAM randomized clinical trial
HIV感染者换用多替拉韦加拉米夫定治疗48周身体成分变化：DOLAM随机临床试验的计划子分析
Elisa de Lazzari and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2226–2233
19
The impact of inter-infection time on antimicrobial resistance profiles in women with multiple urinary tract infections over time
多次尿路感染女性患者感染间隔时间对抗菌药物耐药性特征的影响
Trenton Honda and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2234–2240
20
Development and evaluation of a novel rapid immunochromatographic assay for the detection of DHA-producing Enterobacterales
一种检测产DHA肠杆菌科细菌的新型快速免疫层析法的开发与评估
Christian Moguet and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2241–2246
21
Enterococcus faecium bacteraemia: a multicentre observational study focused on risk factors for clinical and microbiological outcomes
粪肠球菌菌血症：一项关注临床和微生物学结局风险因素的多中心观察性研究
Matteo Rinaldi and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2247–2256
22
Indolocarbazoles as host-directed therapeutics against intracellular infections by methicillin-resistant Staphylococcus aureus
靛红咔唑类化合物作为宿主导向疗法对抗甲氧西林耐药金黄色葡萄球菌细胞内感染
Robin H G A van den Biggelaar and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2257–2268
23
Clinical validation of antimicrobial dosing regimens for continuous renal replacement therapy based on an ex vivo dosing algorithm
基于体外给药算法的连续性肾脏替代治疗抗菌药物给药方案的临床验证
Christina Koenig and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2269–2279
24
Novel integrative and conjugative elements carrying cfr(B) and cfr(C) linezolid resistance genes in Clostridioides difficile isolates from calves, Italy
意大利牛犊艰难梭菌分离株中携带cfr(B)和cfr(C)利奈唑胺耐药基因的新型整合性和接合性元件
Andrea Brenciani and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2280–2284
25
Characterization of Carbapenemase-producing Enterobacterales isolated from patients returning from Sub-Saharan Africa, France, 2015–2022
2015-2022年从撒哈拉以南非洲返回的法国患者中分离出的产碳青霉烯酶肠杆菌科细菌的特征
Corentin Poignon and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2285–2294
26
Penicillin-susceptible ST398 with strong biofilm-forming ability poses a significant threat to osteoarticular infections
具有强生物膜形成能力的青霉素敏感ST398型对骨关节感染构成重大威胁
Ye Jin and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2295–2304
27
Cardiac safety of bedaquiline, delamanid and moxifloxacin co-administered with or without varying doses of sutezolid or delpazolid for the treatment of drug-susceptible TB
贝达喹啉、德拉马尼和莫西沙星与不同剂量苏特唑利或德帕唑利联合用药治疗药物敏感型肺结核的心脏安全性
Simon E Koele and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2305–2313
28
Comparison of ceftolozane/tazobactam and meropenem in treating bloodstream infections caused by extended-spectrum β-lactamase-producing Enterobacterales: a single-centre, retrospective, real-world study
头孢托唑坦/他唑巴坦与美罗培南治疗产超广谱β-内酰胺酶肠杆菌科细菌所致血流感染的对比：一项单中心回顾性现实研究
Dimitrios Basoulis and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2314–2322
Research Letters(研究信件)
29
Dalbavancin as chronic suppressive therapy in a patient undergoing monthly apheresis: a case report with therapeutic drug monitoring
达巴万星作为每月进行血浆置换术患者的长期抑制治疗：一项带治疗药物监测的病例报告
Carlo Pallotto and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2323–2324
30
A novel methicillin-resistant Staphylococcus aureus lineage (ST4174) with an uncharacterized SCCmec variant identified in Korean pigs
韩国猪体内发现的一种带有未表征SCCmec变体的新型甲氧西林耐药金黄色葡萄球菌谱系（ST4174）
Hyeonwoo Cho and Kun Taek Park
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2325–2326
31
Time fixes everything, but not always: 10years of persistent PI mutations in the absence of pharmacological pressure—a case report
时间能治愈一切，但并非总是如此：无药物压力下持续10年的蛋白酶抑制剂突变——一例病例报告
Layla Pagnucco and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2327–2330
32
Carbapenem resistance in Escherichia marmotae: characterization of IncL plasmids carrying blaOXA-48
土拨鼠埃希菌的碳青霉烯耐药性：携带blaOXA-48的IncL质粒特征
Astrid Rasmussen and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2330–2331
Letters to the Editor(致编辑的信)
33
Comment on: Clinical outcomes and the impact of treatment modalities in children with carbapenem-resistant Enterobacteriaceae bloodstream infections: a retrospective cohort study from a tertiary university hospital
述评：产碳青霉烯酶肠杆菌科细菌血流感染患儿的临床预后和治疗方式的影响：一项来自三级大学医院的回顾性队列研究
Jianjun Li and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Page 2332
34
Clinical outcomes and the impact of treatment modalities in children with carbapenem-resistant Enterobacteriaceae bloodstream infections: a retrospective cohort study from a Tertiary University Hospital—right to reply—author’s response
产碳青霉烯酶肠杆菌科细菌血流感染患儿的临床预后和治疗方式的影响：一项来自三级大学医院的回顾性队列研究——作者回复
Gulhadiye Avcu
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Pages 2332–2333
Corrections(更正)
35
Correction to: Sofosbuvir as post-exposure prophylaxis for yellow fever–associated viscerotropic disease (YEL-AVD)
更正：索非布韦作为黄热病相关内脏热带病（YEL-AVD）暴露后预防用药
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Page 2334
36
Correction to: Pandemic human-associated extended-spectrum β-lactamase-producing Escherichia coli lineages of ST38, ST131 and ST141 identified in Viennese dogs
更正：维也纳犬体内发现与人相关的大流行性产超广谱β-内酰胺酶大肠杆菌ST38、ST131和ST141谱系
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Page 2335
37
Correction to: GP or ChatGPT? Ability of large language models (LLMs) to support general practitioners when prescribing antibiotics
更正：全科医生还是ChatGPT？大型语言模型（LLM）在全科医生开具抗生素处方时的辅助能力
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 8, August 2025, Page 2336
Journal of Antimicrobial Chemotherapy, Volume 80, Issue Supplement_2
抗菌化疗杂志 80卷 增刊2期
https://academic.oup.com/jac/issue
SUPPLEMENT (补充)
CANWARD 2007-23
加拿大抗感染耐药监测项目（CANWARD）2007-2023年数据/报告
Foreword(前言)
1
The CANWARD studies: Canadian Antimicrobial Resistance Alliance (CARA) Canadian Hospital Ward Antibiotic Resistance Surveillance collection
加拿大抗感染耐药监测项目研究：加拿大抗微生物耐药联盟（CARA）加拿大医院病房耐药性监测数据集
James C Hurley and Jean-Yves Madec
Journal of Antimicrobial Chemotherapy, Volume 80, Issue Supplement_2, September 2025, Page ii1
Supplement Papers(补充论文)
2
Seventeen years of the CANWARD study (2007–23)
加拿大抗感染耐药监测项目研究17年（2007-2023年）
George G Zhanel and Heather J Adam
Journal of Antimicrobial Chemotherapy, Volume 80, Issue Supplement_2, September 2025, Pages ii2–ii4
3
Gram-positive pathogens from Canadian hospitals: 17years of results from the CANWARD study (2007–23)
来自加拿大医院的革兰氏阳性病原体：加拿大抗感染耐药监测项目研究的17年结果（2007-2023）
George G Zhanel and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue Supplement_2, September 2025, Pages ii5–ii14
4
Gram-negative pathogens from Canadian hospitals: 17 years of results from the CANWARD study (2007–23)
来自加拿大医院的革兰氏阴性病原体：加拿大抗感染耐药监测项目研究的17年结果（2007-2023）
George G Zhanel and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue Supplement_2, September 2025, Pages ii15–ii26
5
Characterization of methicillin-resistant Staphylococcus aureus in Canadian hospitals: 17 years of the CANWARD study (2007–23)
加拿大医院耐甲氧西林金黄色葡萄球菌的特征：加拿大抗感染耐药监测项目研究的17年（2007-2023）
Anissa Brahami and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue Supplement_2, September 2025, Pages ii27–ii34
6
Comparison of antimicrobial resistance and serotype patterns in Streptococcus pneumoniae from blood cultures and respiratory specimens in Canadian hospitals from the CANWARD study (2007–23)
加拿大抗感染耐药监测项目研究中加拿大医院血液培养和呼吸道标本中肺炎链球菌抗微生物药物耐药性和血清型的比较（2007-23）
Heather J Adam and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue Supplement_2, September 2025, Pages ii35–ii44
7
Increasing rates of ESBL-producing Escherichia coli and Klebsiella pneumoniae in Canadian Hospitals: 17 years of the CANWARD study, 2007–23
加拿大医院中产生ESBL的大肠杆菌和肺炎克雷伯菌的比率增加：加拿大抗感染耐药监测项目研究17年，2007-2023
Philippe Lagacé-Wiens and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue Supplement_2, September 2025, Pages ii45–ii53
8
Characterization of ertapenem-resistant Enterobacterales in Canadian hospitals: 17 years of the CANWARD study (2007–23)
加拿大医院耐厄他培宁肠杆菌的特征：17年的加拿大抗感染耐药监测项目研究（2007-23）
Laura F Mataseje and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue Supplement_2, September 2025, Pages ii54–ii61
9
Characterization of carbapenem-resistant Pseudomonas aeruginosa in Canadian hospitals: 6years of the CANWARD study (2018–23)
加拿大医院耐碳青霉烯假单胞菌的特征：6年的加拿大抗感染耐药监测项目研究（2018-23）
Melissa McCracken and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue Supplement_2, September 2025, Pages ii62–ii71
10
Distribution and antimicrobial susceptibility profile of pathogens recovered from the bloodstream of Canadian patients: results from the CANWARD study (2007–23)
加拿大患者血液中病原菌的分布和药敏特征：来自加拿大抗感染耐药监测项目研究（2007-23）的结果
Andrew Walkty and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue Supplement_2, September 2025, Pages ii72–ii82
Journal of Antimicrobial Chemotherapy Volume 80, Issue 9抗菌化疗杂志 80卷 9期
https://academic.oup.com/jac/issue
VIEWPOINT（观点）
1
Classifying patients with invasive fungal disease: towards a unified case definition?
侵袭性真菌病患者分类：能否达成统一的病例定义？
Mehmet Ergün and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2337–2343,
SYSTEMATIC REVIEW（系统综述）
2
Efficacy and safety of earlier switching to an oral antibiotic therapy for the treatment of Gram-positive bloodstream infections: a systematic review and meta-analysis
早期转换为口服抗生素治疗革兰氏阳性菌血流感染的疗效和安全性：一项系统综述和荟萃分析
ZhaoYi Tan and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2344–2360,
ORIGINAL RESEARCH（论著）
3
Determination of epidemiological cut-off values for Narasin, Salinomycin, Lasalocid and Monensin in Enterococcus faecium
屎肠球菌中那拉霉素、盐霉素、拉沙洛西钠和莫能菌素流行病学临界值的测定
Maria Laura Ferrando and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2361–2368,
4
Persistence of CXCR4-tropic virus in people living with four-class drug-resistant HIV and its clinical impact in the modern antiretroviral era
四类耐药HIV感染者体内CXCR4嗜性病毒的持续存在及其在现代抗逆转录病毒治疗时代的临床影响
Rebecka Papaioannu Borjesson and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2369–2374,
5
Hypertension and blood pressure changes with dolutegravir or comparator antiretroviral therapy in randomized trials through 96 weeks
随机试验中96周内使用多替拉韦或对照抗逆转录病毒疗法对高血压和血压变化的影响
Parul Patel and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2375–2383,
6
Comparative analysis of lipid profile changes in treatment-naïve people living with HIV on INSTI-based single-tablet regimens, BIC/FTC/TAF and DTG/3TC: real-world evidence from South Korea
基于整合酶抑制剂的单片复方制剂BIC/FTC/TAF和DTG/3TC在韩国初治HIV感染者中血脂谱变化的比较分析：来自现实世界的证据
So Yun Lim and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2384–2390,
7
A novel multilocus sequence typing scheme for Morganella spp.: population structure and introduction of quantitative metric for standardization of MLST scheme
摩根氏菌属的一种新型多位点序列分型方案：群体结构及引入用于标准化多位点序列分型方案的定量度量标准
Aymeric Jacquemin and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2391–2398,
8
Genomic characterization of multidrug-resistant extended-spectrum β-lactamase-producing Vibrio cholerae O1 strains from 2022 cholera outbreak in Kenya
2022年肯尼亚霍乱疫情中产超广谱β-内酰胺酶的多重耐药霍乱弧菌O1株的基因组特征
Diana Imoli and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2399–2407,
9
Impact of empiric anti-VRE therapy on survival in vancomycin-resistant enterococcal bloodstream infection
经验性抗万古霉素耐药肠球菌治疗对万古霉素耐药肠球菌血流感染患者生存率的影响
Tao-Hung Ou and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2408–2416,
10
Safety of topical tobramycin powder during operative treatment of fractures
骨折手术中使用局部妥布霉素粉末的安全性
Gregory M Schrank and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2417–2420,
11
Trimethoprim/sulfamethoxazole and risk of haemophagocytic lymphohistiocytosis (HLH): a literature review and disproportionality analysis using individual case safety reports from FAERS
复方磺胺甲恶唑与噬血细胞性淋巴组织细胞增多症（HLH）的风险：基于FAERS数据库个案安全报告的文献综述和比例失衡分析
Rinko Lau and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2421–2427,
12
Highly drug-resistant Vibrio cholerae harbouring blaPER-7 isolated from travellers returning to England
从返回英国的旅行者中分离出携带blaPER-7基因的高度耐药霍乱弧菌
Satheesh Nair and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2428–2432,
13
Overcoming antimicrobial resistance in Helicobacter pylori: the roles of collateral sensitivity and biofilm dynamics
克服幽门螺杆菌的抗菌药物耐药性：附带敏感性和生物膜动态的作用
Siddharth Singh and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2433–2441,
14
Clinical and microbiological analysis of bloodstream infections by four cefiderocol-resistant and not previously exposed NDM-producing Klebsiella pneumoniae
四种未接触过但对头孢地尔耐药的产NDM肺炎克雷伯菌所致血流感染的临床和微生物学分析
Maria Mazzitelli and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2442–2446,
15
Synergistic effects of DHA27 combined with gentamicin against methicillin-resistant Staphylococcus aureus in vitro and in vivo
DHA27与庆大霉素联合对耐甲氧西林金黄色葡萄球菌的体内外协同作用
Xuemin Chen and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2447–2458,
16
A multicentre study for determination of epidemiological cut-off values for Candida auris with EUCAST broth microdilution reference methodology
采用EUCAST肉汤微量稀释参考方法进行耳念珠菌流行病学临界值的多中心测定研究
Joseph Meletiadis and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2459–2465,
17
Impact of vancomycin resistance on attributable mortality among Enterococcus faecium bloodstream infections: propensity score analysis of a large, multicentre retrospective study
万古霉素耐药对屎肠球菌血流感染归因死亡率的影响：一项大型多中心回顾性研究的倾向评分分析
M Del Monte and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2466–2473,
18
Dynamics of dual CMV and EBV co-reactivation and emergence of resistance in an HSCT recipient
异基因造血干细胞移植受者中CMV和EBV双重再激活的动态变化及耐药性的出现
Martyna Pociupany and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2474–2483,
19
Antimicrobial use for the treatment of bacterial sexually transmitted infections among doxycycline post-exposure prophylaxis (DoxyPEP) users in Milan, Italy
意大利米兰多西环素暴露后预防（DoxyPEP）使用者中用于治疗细菌性性传播感染的抗菌药物使用情况
Angelo Roberto Raccagni and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2484–2486,
20
Comparing the mortality of patients with sepsis using empirical piperacillin/tazobactam and cefepime: analysis of the MIMIC-IV database
使用经验性哌拉西林/他唑巴坦和头孢吡肟的脓毒症患者死亡率比较：基于MIMIC-IV数据库的分析
Yongseop Lee and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2487–2495,
21
Transmitted drug resistance profiles among people living with HIV-1 in Henan province, China, 2024
2024年中国河南省HIV-1感染者传播耐药情况
Jinjin Liu and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2496–2502,
22
Fluctuations in copy number of the class A carbapenemase gene blaFRI appear to confer high-level carbapenem resistance
A类碳青霉烯酶基因blaFRI拷贝数的波动似乎赋予了高水平碳青霉烯耐药性
Makiko Noda and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2503–2512,
23
In vitro activity of ceftobiprole plus ampicillin against Enterococcus faecalis causing infective endocarditis: phenotypic and genotypic characterization
头孢比罗联合氨苄西林对引起感染性心内膜炎的粪肠球菌的体外活性：表型和基因型特征
Clara Moretó-Castellsaguéand others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2513–2523,
24
Paradoxical interaction between dalbavancin and β-lactams against endocarditis-associated Enterococcus faecalis clinical isolates
达巴万星与β-内酰胺类药物对心内膜炎相关粪肠球菌临床分离株的矛盾相互作用
David Luque Paz and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2524–2529,
25
Comparative evaluation of broth microdilution and gradient diffusion methods in Burkholderia cepacia complex susceptibility testing: implications of transitioning to ECV-based interpretation
伯克霍尔德菌复合群药敏试验中肉汤微量稀释法和梯度扩散法的比较评估：向基于ECV解释转变的影响
Wenjie Cui and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2530–2540,
26
Strengthening antimicrobial resistance diagnostics in National Reference Laboratories across One Health in South and Southeast Asia: impact of external quality assessment and targeted follow-up
加强南亚和东南亚“同一健康”国家参考实验室的抗菌药物耐药性诊断能力：外部质量评估和针对性随访的影响
Freshwork Ayalew Abegaz and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2541–2549,
RESEARCH LETTERS（研究快信）
27
TDM-guided meropenem/vaborbactam-based therapy for successful treatment of intra-abdominal and bloodstream infection caused by KPC-producing ceftazidime/avibactam-resistant Klebsiella pneumoniae in a paediatric liver transplant recipient
治疗药物监测指导下的美罗培南/瓦博巴坦疗法成功治疗儿童肝移植受者中产KPC且对头孢他啶/阿维巴坦耐药的肺炎克雷伯菌引起的腹腔和血流感染
Giovanni Mulé and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2550–2552,
28
Novel tmexC7D2-toprJ5 gene cluster and transposon Tn7759 carrying blaVIM-2 and blaOXA-10 genes in a carbapenem-resistant Pseudomonas putida from urban sewage
城市污水中碳青霉烯耐药恶臭假单胞菌中携带blaVIM-2和blaOXA-10基因的新型tmexC7D2-toprJ5基因簇和转座子Tn7759
Xinyuan Qiu and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2552–2555,
29
Characterization of multiresistance gene optrA in Bacillus subtillis from China
中国枯草芽孢杆菌中多重耐药基因optrA的特征分析
Yongliang Che and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2555–2557,
30
Genomic characterization of a multidrug-resistant Mammaliicoccus sciuri strain isolated from urine of a patient from China
从中国患者尿液中分离出的一株多重耐药马氏鼠球菌的基因组特征
Fuqiang Ye and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2558–2560,
LETTERS TO THE EDITOR（致编辑的信）
31
Comment on: Isavuconazole therapeutic drug monitoring and association with adverse events
关于“艾沙康唑治疗药物监测及其与不良反应的关联”的评论
Mi Zhou and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2561–2562,
32
Comment on: Outcomes of ceftriaxone 2 g versus 1 g daily in hospitalised patients with pneumonia: a nationwide retrospective cohort study
关于“住院肺炎患者每日2克与1克头孢曲松疗效比较：一项全国性回顾性队列研究”的评论
Satoru Mitsuboshi
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Page 2563,
33
Outcomes of ceftriaxone 2 g versus 1 g daily in hospitalized patients with pneumonia: a nationwide retrospective cohort study—authors’ response
住院肺炎患者每日2克与1克头孢曲松疗效比较：一项全国性回顾性队列研究——作者回复
Jumpei Taniguchi and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 9, September 2025, Pages 2563–2564,
Journal of Antimicrobial Chemotherapy Volume 80, Issue 10抗菌化疗杂志 80卷 10期
https://academic.oup.com/jac/issue
REVIEWS（综述）
1
Long-acting cabotegravir and rilpivirine for the treatment of people with HIV: current landscape and challenges ahead
长效卡博特韦和利匹韦林治疗HIV感染者的现状与未来挑战
Luis Buzón-Martín and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2565–2586,
2
Systematic reviews and the Journal of Antimicrobial Chemotherapy; past, present and future. A systematic reappraisal
系统综述与《抗菌化疗杂志》：过去、现在与未来——系统再评估
James C Hurley
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2587–2596,
SYSTEMATIC REVIEWS（系统综述）
3
Studying intrapulmonary pharmacokinetics for tuberculosis treatment: a systematic review of methodology
研究肺结核治疗的肺内药代动力学：方法学的系统综述
Isabella van der Feltz and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2597–2608,
4
Global prevalence of nitrofurantoin-resistant uropathogenic Escherichia coli (UPEC) in humans: a systematic review and meta-analysis
全球人类中耐呋喃妥因的尿路致病性大肠埃希菌（UPEC）流行率：系统综述与荟萃分析
Christopher Larkin and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2609–2621,
ORIGINAL RESEARCH（研究论著）
5
Is ampicillin plus cephalosporins a therapeutic option for Ampicillin-Susceptible Enterococcus faecium?
氨苄青霉素联合头孢菌素是否为氨苄青霉素敏感的粪肠球菌的治疗选择？
Paula Bierge and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2622–2629,
6
Therapeutic efficacy monitoring of pyronaridine–artesunate (Pyramax®) in treating uncomplicated Plasmodium falciparum malaria in Gia Lai province, Vietnam from 2022 to 2023
2022-2023年越南嘉莱省青蒿琥酯-吡咯尼抗（Pyramax®）用于无并发症恶性疟原虫疟疾的治疗效果监测
Nguyen Van Thanh and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2630–2634,
7
Effectiveness of piperacillin/tazobactam loading dose for extended infusion dosing among patients with Gram-negative bacteraemia
哌拉西林/他唑巴坦负荷剂量用于革兰氏阴性菌血症患者延长输注给药的有效性
Savan Patel and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2635–2643,
8
Intrapulmonary concentrations of ceftobiprole high doses administered by continuous infusion in critically ill patients with community-acquired pneumonia
连续输注大剂量头孢比罗在社区获得性肺炎危重患者中的肺内浓度
Claire Roger and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2644–2653,
9
Cefixime versus benzathine penicillin G for the treatment of early syphilis—a randomized, controlled open label trial
头孢克肟与苄星青霉素G治疗早期梅毒的随机对照开放标签试验
Tamara Klementová and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2654–2658,
10
Trends in antifungal use among hospitalized patients in the USA, 2018–23
2018-2023年美国住院患者抗真菌药物使用趋势
Dallas J Smith and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2659–2664,
11
Clinical impact of the BCID2 and rapid AST VITEK® REVEALTM on antibiotic optimisation in critically ill patients with Gram-negative bloodstream infections: a quasi-experimental pre/post interventional study
BCID2和快速AST VITEK® REVEALTM对革兰氏阴性菌血流感染危重患者抗生素优化的临床影响：一项准实验性前后干预研究
Louis Oudiane and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2665–2675,
12
In vitro activity of thiamphenicol against drug-susceptible and drug-resistant strains of Mycoplasma genitalium
甲砜霉素对药物敏感和耐药生殖支原体菌株的体外活性
Sofie Skovmand and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2676–2681,
13
A priori optimization of levofloxacin dose regimen based on a population pharmacokinetics model
基于群体药代动力学模型的左氧氟沙星剂量方案先验优化
Emmanuel Enard and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2682–2692,
14
Model-informed individualized administration of ceftazidime–avibactam in critically ill patients: population pharmacokinetics studies and a parametric time-to-event analysis
危重患者头孢他啶-阿维巴坦的模型知情个体化给药：群体药代动力学研究和参数时间事件分析
Tingting Wu and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2693–2704,
15
Development of blood culture time-to-positivity as a pharmacodynamic indicator for monitoring antibiotic therapy against MDR Gram-negative bacteria
开发血培养阳性时间作为监测针对多重耐药革兰氏阴性菌抗生素治疗的药效动力学指标
Irene Zaghi and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2705–2713,
16
In vivo activity of ceftibuten-ledaborbactam oral combination against serine-β-lactamase-producing Enterobacterales: an assessment in the pyelonephritis and cystitis murine model
头孢布坦-莱达博巴坦口服联合用药对产丝氨酸-β-内酰胺酶肠杆菌科细菌的体内活性评估：在肾盂肾炎和膀胱炎小鼠模型中的评估
Christina Koenig and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2714–2718,
17
Faecal pharmacokinetics, microbiome, and bile acid changes in healthy subjects given intravenous followed by oral omadacycline; a Phase 1 clinical trial
健康受试者静脉注射后口服奥马环素的粪便药代动力学、微生物组和胆汁酸变化：一项1期临床试验
Jinhee Jo and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2719–2726,
18
Interlaboratory comparison of a dried blood spot assay for antiretroviral adherence: implications for clinical application
抗逆转录病毒治疗依从性干血斑检测法的实验室间比对：对临床应用的启示
Nathan Engel and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2727–2731,
19
A multicentre real-life prospective cohort study on effectiveness, durability and safety of long-acting injectable cabotegravir and rilpivirine in northern Italy: the LONGITUDE study
意大利北部长效注射用卡博特韦和利匹韦林有效性、持久性和安全性的现实中多中心前瞻性队列研究：LONGITUDE研究
Maria Mazzitelli and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2732–2741,
20
Assessment of the risk of developing cefepime-induced abnormal liver enzyme levels using the albumin–bilirubin score and fibrosis-4 index: a single-centre retrospective case–control study
使用白蛋白-胆红素评分和纤维化-4指数评估头孢吡肟诱导的肝酶水平异常发生风险：一项单中心回顾性病例对照研究
Hiroki Katsu and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2742–2751,
21
Clinical course of patients with bloodstream infections enrolled in the BALANCE clinical trial
BALANCE临床试验中血流感染患者的临床病程
Sean W X Ong and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2752–2758,
22
Comparative outcomes of polymyxins in neurocritical care patients with carbapenem-resistant Gram-negative bacterial pneumonia: a retrospective cohort study
神经重症患者中多黏菌素治疗碳青霉烯类耐药革兰氏阴性菌肺炎的结果比较：一项回顾性队列研究
Qian Zeng and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2759–2772,
23
Distinct population structure and genomic context of NarAB between broiler and human clinical Enterococcus isolates
肉鸡和人类临床分离的粪肠球菌中NarAB的不同群体结构和基因组背景
Jayanth Balakuntla and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2773–2781,
24
Population pharmacokinetics of bictegravir in real-world people with HIV
现实中HIV感染者比克替拉韦的群体药代动力学
Pierre Ekobena and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2782–2789,
25
Rifampicin concentrations throughout the entire treatment duration of active tuberculosis; impact of sex and body mass index
活动性肺结核整个治疗期间利福平浓度：性别和体重指数的影响
Teres Samuelsson and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2790–2798,
26
Performance of disc diffusion and gradient strip test on different Mueller–Hinton agar media plates and ComASP® and Bruker UMIC® Cefiderocol Microdilution Panels for cefiderocol susceptibility testing in carbapenem-resistant Pseudomonas aeruginosa
在碳青霉烯类耐药铜绿假单胞菌中对头孢地尔敏感性测试使用不同穆勒-欣顿琼脂培养基平板和ComASP®及Bruker UMIC®头孢地尔微量稀释板的纸片扩散法和梯度条带测试的性能
Stefano Mancini and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2799–2806,
27
Placental transfer of medications to treat COVID-19, molnupiravir, favipiravir and nirmatrelvir/ritonavir, in the ex vivo human cotyledon model
在离体人类绒毛叶模型中治疗COVID-19的药物莫努匹拉韦、法维拉韦和奈玛特韦/利托那韦的胎盘转移
Solene Labaye and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2807–2813,
28
Synergistic cefiderocol-containing antibiotic combinations active against highly drug-resistant Acinetobacter baumannii patient isolates with diverse resistance mechanisms
针对具有多种耐药机制的高度耐药鲍曼不动杆菌患者分离株的含头孢地尔抗生素联合用药的协同作用
Justin Halim and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2814–2824,
29
Uptake of drug-reduced antiretroviral strategies and impact on costs over 2015–22: experience from an HIV clinic in Paris, France
2015-2022年药物减量抗逆转录病毒策略的采用情况及对成本的影响：来自法国巴黎一家HIV诊所的经验
L Sagaon-Teyssier and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2825–2833,
30
Molecular characterization of fluoroquinolone resistance in invasive clinical isolates of Streptococcus pneumoniae susceptible to delafloxacin
对达拉氟沙星敏感的侵袭性临床肺炎链球菌分离株中氟喹诺酮耐药性的分子特征
Emilia Cercenado and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2834–2843,
31
Genomic structure of class 1 and 2 integrons in non-typhoidal Salmonella isolated from food animals and related meat products in the USA
美国食品动物及其相关肉类产品中分离的非伤寒沙门氏菌1类和2类整合子的基因组结构
Chih-Hao Hsu and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2844–2853,
32
Characterization of blaOXA-542-mediated carbapenem resistance in Acinetobacter baumannii
鲍曼不动杆菌中blaOXA-542介导的碳青霉烯类耐药性的特征
Jingchen Hao and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2854–2861,
33
Phenotypic and genotypic profiles of clinical isolates of various Nocardia species to carbapenems and fluoroquinolones
各种诺卡氏菌属临床分离株对碳青霉烯类和氟喹诺酮类的表型和基因型特征
Jing Yang and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2862–2872,
RESEARCH LETTERS（研究快报）
34
Oritavancin in a patient with recurrent endocarditis by Enterococcus faecalis: a new therapeutic option?
奥利他万星治疗粪肠球菌复发性心内膜炎患者：一种新的治疗选择？
Giulia Turicchi and Marco Bongiovanni
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2873–2874,
35
The catA1 chloramphenicol resistance gene originated in Atlantibacter hermannii
catA1氯霉素耐药基因起源于大西洋菌属赫尔曼尼菌
Robert A Moran and Ruth M Hall
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2874–2876,
36
Horizontal transmission of a multidrug-resistant IncM1 plasmid harbouring blaOXA-48 and blaCTX-M-14b among patient microbiotas
携带blaOXA-48和blaCTX-M-14b的多重耐药IncM1质粒在患者微生物群中的水平传播
Roberto Sierra and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2876–2879,
37
Antimicrobial activity of temocillin on ceftriaxone-resistant and ceftriaxone-susceptible isolates of Neisseria gonorrhoeae
替莫西林对头孢曲松耐药和头孢曲松敏感淋病奈瑟菌分离株的抗菌活性
Julie Brousseau and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2879–2881,
LETTERS TO THE EDITOR（致编辑的信）
38
Comment on: Bactericidal activity of antibiotic combinations against clinical isolates of Enterococcus gallinarum and Enterococcus casseliflavus
述评：抗生素联合用药对临床分离的鸡肠球菌和粪肠球菌的杀菌活性
Karl Oldberg and Magnus Rasmussen
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2882–2883,
39
Comment on: Outcomes of ceftriaxone 2 g versus 1 g daily in hospitalized patients with pneumonia: a nationwide retrospective cohort study
述评：住院肺炎患者每日2克与1克头孢曲松的疗效：一项全国性回顾性队列研究
Giancarlo Ceccarelli and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2884–2885,
40
Outcomes of ceftriaxone 2 g versus 1 g daily in hospitalized patients with pneumonia: a nationwide retrospective cohort study—right to reply—authors’ response
住院肺炎患者每日2克与1克头孢曲松的疗效：一项全国性回顾性队列研究——作者回应权——作者回复
Jumpei Taniguchi and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 10, October 2025, Pages 2885–2886,
Journal of Antimicrobial Chemotherapy Volume 80, Issue Supplement_4抗菌化疗杂志 80卷 增刊4期
https://academic.oup.com/jac/issue/80/Supplement_4
SUPPLEMENT（补充）
Two Decades of BSAC Resistance Surveillance
英国抗菌化疗学会二十年耐药性监测
FOREWORD（前言）
1
Two Decades of BSAC Resistance Surveillance
英国抗菌化疗学会二十年耐药性监测
James C Hurley and Alan P Johnson
Journal of Antimicrobial Chemotherapy, Volume 80, Issue Supplement_4, October 2025, Page iv1,
SUPPLEMENT PAPERS（补充论文）
2
Two decades of resistance surveillance by the British Society for Antimicrobial Chemotherapy: design, development, delivery, deficiencies and future directions
英国抗菌化疗学会二十年耐药性监测：设计、发展、实施、不足与未来方向
Alasdair P MacGowan and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue Supplement_4, October 2025, Pages iv2–iv6,
3
The British Society for Antimicrobial Chemotherapy Resistance Surveillance Project: methods and limitations
英国抗菌化疗学会耐药性监测项目：方法与局限性
Michael Allen and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue Supplement_4, October 2025, Pages iv7–iv21,
4
Antimicrobial resistance among Gram-positive agents of bacteraemia in the UK and Ireland: trends from 2001 to 2019
英国和爱尔兰地区革兰氏阳性菌血流感染病原体的抗菌药物耐药性趋势（2001 - 2019年）
Rosy Reynolds and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue Supplement_4, October 2025, Pages iv22–iv35,
5
Antimicrobial resistance among Gram-negative agents of bacteraemia in the UK and Ireland: trends from 2001 to 2019
英国和爱尔兰地区革兰氏阴性菌血流感染病原体的抗菌药物耐药性趋势（2001 - 2019年）
Rosy Reynolds and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue Supplement_4, October 2025, Pages iv36–iv48,
6
Antimicrobial resistance among agents of hospital-acquired lower respiratory tract infection in the UK and Ireland: trends from 2008/2009 to 2018/2019
英国和爱尔兰地区医院获得性下呼吸道感染病原体的抗菌药物耐药性趋势（2008/2009 - 2018/2019年）
Rosy Reynolds and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue Supplement_4, October 2025, Pages iv49–iv59,
7
Antimicrobial resistance among agents of community-associated lower respiratory tract infection in the UK and Ireland: trends from 1999/2000 to 2018/2019
英国和爱尔兰地区社区获得性下呼吸道感染病原体的抗菌药物耐药性趋势（1999/2000 - 2018/2019年）
Rosy Reynolds and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue Supplement_4, October 2025, Pages iv60–iv71,
8
Trends of serotypes and resistance among Streptococcus pneumoniae in the UK and Ireland (1999–2019)
英国和爱尔兰地区肺炎链球菌血清型及耐药性趋势（1999 - 2019年）
Carolyne Horner and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue Supplement_4, October 2025, Pages iv72–iv86,
9
Applications and benefits of the British Society for Antimicrobial Chemotherapy Resistance Surveillance Project—legacy and future
英国抗菌化疗学会耐药性监测项目的应用与益处——成果与未来
Benjamin J Parcell and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue Supplement_4, October 2025, Pages iv87–iv95,
Journal of Antimicrobial Chemotherapy Volume 80, Issue 11抗菌化疗杂志 80卷 11期
https://academic.oup.com/jac/issue
VIEWPOINTS（观点）
1
Modification of antimicrobial susceptibility testing methods
抗菌药物敏感性检测方法的修改
Ian Morrissey and Jean B Patel
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 2887–2888,
2
Viewpoint: global antimicrobial stewardship accreditation is needed: the experience in Kentucky, USA
观点：需要建立全球抗菌药物管理认证体系：美国肯塔基州的经验
Ashley M Wilde and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 2889–2891,
REVIEWS（综述）
3
Phages connect the biological dots of antimicrobial resistance: from genesis and spread to alternative treatment modules
噬菌体揭示抗菌药物耐药性的生物学脉络：从起源与传播到替代治疗模式
Cleo Anastassopoulou and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 2892–2901,
4
Molecular drivers of fusion plasmid: mechanistic insights and evolutionary implications
融合质粒的分子驱动因素：机制见解与进化意义
Ziyi Liu and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 2902–2911,
ORIGINAL RESEARCH（研究论著）
5
Emergence of livestock-associated MRSA clonal complex 398 in Thailand’s swine industry
泰国养猪业中出现与牲畜相关的MRSA克隆复合体398
Pawarut Narongpun and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 2912–2917,
6
Peripheral neuropathy during long-term suppressive therapy with tedizolid: a case series
长期使用替达拉韦抑制治疗期间出现周围神经病变：系列病例报告
Tomaso Beringheli and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 2918–2922,
7
Low bacterial metabolism as a central mechanism of antimicrobial resistance and potential therapeutic target of staphylococcal biofilms in ventricular assist device driveline infections
细菌低代谢作为抗菌药物耐药性的核心机制及心室辅助装置驱动线感染中葡萄球菌生物膜的潜在治疗靶点
Yao Sun and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 2923–2933,
8
The pivotal role of acnA in linking carbon metabolism to virulence and antimicrobial resistance in methicillin-resistant Staphylococcus aureus
acnA在连接碳代谢与耐甲氧西林金黄色葡萄球菌的毒力和抗菌药物耐药性中的关键作用
Jiahui Li and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 2934–2944,
9
Pharmacokinetics of rifampicin and isoniazid in patients with HIV–tuberculosis coinfection receiving efavirenz-based antiretroviral treatment: an ANRS12292–RIFAVIRENZ sub-study
接受以依非韦伦为基础的抗逆转录病毒治疗的HIV-结核病共感染患者中利福平和异烟肼的药代动力学：ANRS12292-RIFAVIRENZ子研究
Thibaut Gelé and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 2945–2953,
10
Novel mutations associated with clofazimine resistance in Mycobacterium intracellulare
胞内分枝杆菌中与氯法齐明耐药相关的新型突变
Xiuzhi Jiang and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 2954–2957,
11
Physiologically informed in vitro framework reveals context-dependent combinatory activity of niclosamide–colistin against Gram-negative bacteria
基于生理信息的体外框架揭示了针对革兰氏阴性菌的硝基咪唑-多粘菌素组合的情境依赖性活性
Mariana Romero-Gonzalez and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 2958–2969,
12
In vitro evolution provides insights into mechanisms of Mycoplasma genitalium resistance to moxifloxacin
体外进化揭示生殖支原体对莫西沙星的耐药机制
Teck-Phui Chua and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 2970–2977,
13
The toxin–antitoxin system SavRS contributes to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus by mediating cell wall thickening
毒素-抗毒素系统SavRS通过介导细胞壁增厚促进万古霉素中间型金黄色葡萄球菌对万古霉素的耐药性
Weifeng Xu and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 2978–2988,
14
Molecular insights into carbapenemase-producing Enterobacterales from Senegal
塞内加尔产碳青霉烯酶肠杆菌目细菌的分子特征
Ousmane Sow and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 2989–3000,
15
Population pharmacokinetic model of linezolid and its metabolite PNU-142300 in elderly patients
老年患者中利奈唑胺及其代谢产物PNU-142300的群体药代动力学模型
Xianglong Chen and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 3001–3010,
16
In vitro activity of contezolid and other comparators against clinical Staphylococcus and Enterococcus: a multicenter study in China
在中国开展的一项多中心研究中，康替唑胺及其他对照药物对临床分离的金黄色葡萄球菌和肠球菌的体外活性
Rongqi Lu and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 3011–3020,
17
Co-existence of the oxazolidinone resistance genes cfr and optrA on a novel multiresistance plasmid from a methicillin-resistant Macrococcoides bohemicum strain
从一株耐甲氧西林的马科考代菌属波希米亚菌株中发现的携带恶唑烷酮耐药基因cfr和optrA的新型多重耐药质粒
Yao Zhu and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 3021–3025,
18
Multidrug resistance and recurrence in urinary bacteraemia among cancer patients
癌症患者中尿路菌血症的多药耐药性和复发情况
Ignacio Grafia and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 3026–3033,
19
Rapid replacement of blaKPC variant in ST11 carbapenem-resistant and hypervirulent Klebsiella pneumoniae contributed to ceftazidime/avibactam resistance during severe in vivo infection
在严重的体内感染期间，ST11型碳青霉烯耐药且高毒力的肺炎克雷伯菌中blaKPC变体的快速替代导致头孢他啶/阿维巴坦耐药
Ping Yang and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 3034–3042,
20
Potential human health risk of carbapenem-non-susceptible Pseudomonas aeruginosa from companion animals
伴侣动物中碳青霉烯类不敏感铜绿假单胞菌对人类健康的潜在风险
Jirachaya Toyting-Hiraishi and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 3043–3056,
21
Assessment of an LC coupled with tandem MS (LC-MS/MS) tool in the detection of antimicrobial resistance mechanisms in Enterobacterales
液相色谱-串联质谱（LC-MS/MS）工具在检测肠杆菌目细菌抗菌药物耐药机制中的应用评估
Anna Witkowska and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 3057–3064,
22
Multidrug efflux pumps and innate azole resistance of Mucor lusitanicus
毛霉属葡萄牙菌的多药外排泵及其固有唑类耐药性
Stephanie Toepfer and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 3065–3078,
23
Ivermectin dosing for children under 2 years
2岁以下儿童的伊维菌素剂量
Wenyu Yang and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 3079–3081,
24
Effectiveness of first-line lamivudine/dolutegravir antiretroviral therapy in persons with HIV: real-life data from the ICONA Foundation cohort
一线拉米夫定/多替拉韦抗逆转录病毒疗法在HIV感染者中的有效性：来自ICONA基金会队列的现实数据
Alessandra Vergori and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 3082–3091,
25
Eligibility and factors associated with long-acting injectable cabotegravir-rilpivirine initiation in an urban academic HIV clinic
城市学术型HIV诊所中长效注射用卡博特韦-利匹韦林启动的资格及关联因素
Geoffroy Liegeon and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 3092–3100,
26
Evaluation of HIV-1 DNA resistance evolution in highly treatment-experienced and multi-resistant individuals under suppressive antiretroviral therapy: a longitudinal study from the PRESTIGIO Registry
在接受抑制性抗逆转录病毒治疗的高度治疗经验丰富和多药耐药个体中，HIV-1 DNA耐药演变的评估：来自PRESTIGIO登记处的纵向研究
D Armenia and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 3101–3106,
27
Sequential antibiotic exposure restores antibiotic susceptibility
序贯抗生素暴露恢复抗生素敏感性
Farhan R Chowdhury and Brandon L Findlay
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 3107–3117,
28
Dermatological adverse effects of doxycycline as post-exposure prophylaxis for sexually transmitted infections among men who have sex with men: real-world findings from a multicentre study
在男男性行为者中，使用多西环素作为性传播感染暴露后预防的皮肤科不良反应：一项多中心研究的现实发现
Ling-Ya Chen and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 3118–3122,
29
Phenotype–genotype discordance in antimicrobial resistance profiles of Gram-negative uropathogens recovered from catheter-associated urinary tract infections in Egypt
埃及导管相关尿路感染中分离的革兰氏阴性尿路病原菌抗菌药物耐药性表型-基因型不一致性
Mohamed Eladawy and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 3123–3132,
30
How should APOBEC3-induced resistance mutations be considered in the management of antiretroviral therapy?
在抗逆转录病毒治疗管理中，应如何考虑APOBEC3诱导的耐药突变？
Marie Gilbert and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 3133–3138,
31
In vitro evaluation of olorofim and antifungal combinations against Aspergillus and Candida species
奥洛芬和抗真菌药物组合对曲霉菌和念珠菌属的体外评价
Corinne Pinder and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 3139–3149,
32
Antagonistic interaction between posaconazole and olorofim in a murine model of invasive pulmonary aspergillosis
在侵袭性肺曲霉病小鼠模型中，泊沙康唑与奥洛芬之间的拮抗作用
Christopher A Darlow and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 3150–3159,
33
High level of archived and circulating HIV-1 drug resistance mutations in adolescents with a detectable viremia in Cameroon
喀麦隆可检测到病毒载量的青少年中HIV-1药物耐药突变的存档和循环水平较高
Armando B D Djiyou and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 3160–3164,
RESEARCH LETTERS（研究快讯）
34
SCY-247, a novel second-generation triterpenoid antifungal, demonstrates high in vitro activity against genetically diverse Candida auris isolates, including FKS1 mutants
新型第二代三萜类抗真菌药物SCY-247对包括FKS1突变体在内的多种基因型耳道假丝酵母菌显示出高体外活性
Bram Spruijtenburg and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 3165–3166,
35
Drug–drug interactions between tirzepatide and antiretrovirals: time to reassess and reassure?
替西帕肽与抗逆转录病毒药物之间的药物-药物相互作用：是时候重新评估和安心了吗？
Andrea Poloni and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 3167–3168,
36
Does the use of topical azoles have an impact on antifungal resistance?
局部使用唑类药物对抗真菌耐药性有影响吗？
Jean-Yves Maillard
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 3168–3186,
37
Leakage of cabotegravir and rilpivirine in HIV patients receiving long-acting injectable antiretroviral therapy
接受长效注射用抗逆转录病毒治疗的HIV患者中卡博特韦和利匹韦林的泄漏情况
Samir Benkouiten and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Pages 3187–3188,
CORRECTION（更正）
38
Correction to: Clinical and microbiological analysis of bloodstream infections by four cefiderocol-resistant and not previously exposed NDM-producing Klebsiella pneumoniae
更正：对四种产NDM且之前未接触过头孢地洛的耐药肺炎克雷伯菌引起的血流感染的临床和微生物学分析
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 11, November 2025, Page 3189,
Journal of Antimicrobial Chemotherapy Volume 80, Issue 12抗菌化疗杂志 80卷 12期
https://academic.oup.com/jac/issue
VIEWPOINT（观点）
1
Rifampicin as monotherapy for infections caused by Staphylococcus aureus: considerations for not applying ‘breakpoints in brackets’
利福平单药治疗金黄色葡萄球菌感染：关于不应用“括号内折点”的考量
Sara E Boyd and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3191–3193,
REVIEWS（综述）
2
The Achilles’ heel of the Trojan Horse? A systematic evaluation of cefiderocol susceptibility testing
特洛伊木马的致命弱点？头孢地尔药敏试验的系统评价
Deny Tsakri and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3194–3207,
3
Antifungal treatment strategies and their impact on resistance development in clinical settings
抗真菌治疗策略及其对临床环境中耐药性发展的影响
Norman Van Rhijn and P Lewis White
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3208–3226,
ORIGINAL RESEARCH（论著）
4
Decrease in colistin resistance among young bovine and pig productions in France: relationship with colistin usage and stewardship measures
法国年轻牛和猪生产中多粘菌素耐药性的下降：与多粘菌素使用及管理措施的关系
Claire Chauvin and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3227–3235,
5
Time to anti-cancer treatment resumption after SARS-CoV-2 infection in patients with active haematological diseases undergoing combined antiviral treatments
接受联合抗病毒治疗的活动性血液系统疾病患者感染SARS-CoV-2后恢复抗癌治疗的时间
E Matteini and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3236–3241,
6
From TRIO to one: simplification to bictegravir/emtricitabine/tenofovir alafenamide in highly treatment-experienced people living with MDR HIV
从三联疗法到单一疗法：在多重耐药HIV感染且治疗经验丰富的人群中简化使用比克替拉韦/恩曲他滨/丙酚替诺福韦
José L Casado and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3242–3247,
7
Effects of commonly used antibiotics on children’s developing gut microbiomes and resistomes in peri-urban Lima, Peru
秘鲁利马市郊常用抗生素对儿童发育中的肠道微生物组和耐药组的影响
Neha Sehgal and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3248–3256,
8
Frailty Index Laboratory (FI-Lab) as predictor of poor outcomes for intra-hospital multidrug-resistant Klebsiella pneumoniae bloodstream infections: a single-centre retrospective cohort study
衰弱指数实验室（FI-Lab）作为预测院内多重耐药肺炎克雷伯菌血流感染不良预后的指标：一项单中心回顾性队列研究
Carmen Pellegrino and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3257–3264,
9
Mechanisms of resistance to ceftazidime/avibactam in mutants derived in vitro from Klebsiella pneumoniae producing OXA-48-like enzymes
体外衍生的产OXA-48样酶肺炎克雷伯菌突变体对头孢他啶/阿维巴坦的耐药机制
T Blanco-Martín and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3265–3272,
10
Comparative evaluation of disc diffusion and broth microdilution methods for aztreonam/avibactam susceptibility testing in Enterobacterales
肠杆菌目中氨曲南/阿维巴坦药敏试验的纸片扩散法和肉汤微量稀释法的比较评价
Ioannis Baltas and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3273–3277,
11
Efficacy of topical hydrophilic gel of paromomycin combined with systemic or locally administered leishmanicidal drugs for treatment of experimental leishmaniasis caused by Leishmania (Viannia) braziliensis
硫酸巴龙霉素亲水性凝胶局部用药联合全身或局部使用杀利什曼原虫药物治疗巴西利什曼原虫（Viannia亚属）引起的实验性利什曼病的疗效
Líndicy Leidicy Alves and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3278–3287,
12
Population pharmacokinetics and dosing optimization of cefoselis in paediatric patients with haematological malignancies
血液系统恶性肿瘤患儿中头孢噻利的群体药代动力学及剂量优化
Jing-Rui Liu and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3288–3296,
13
Therapeutic challenges in treating ESBL- and/or AmpC-producing non-carbapenemase-producing Enterobacterales: an in vitro evaluation of novel β-lactam/β-lactamase inhibitor combinations and cefiderocol
治疗产超广谱β-内酰胺酶（ESBL）和/或AmpC酶且不产碳青霉烯酶的肠杆菌目细菌的挑战：新型β-内酰胺/β-内酰胺酶抑制剂组合和头孢地尔的体外评价
Inès Rezzoug and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3297–3305,
14
Post-exposure prophylaxis with doxycycline (DoxyPEP) to prevent STIs in a real-world setting: the PRIDOX study
使用多西环素进行暴露后预防（DoxyPEP）以在现实环境中预防性传播感染：PRIDOX研究
R Palacios and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3306–3310,
15
Risk–benefit balance of blood cultures among patients with stage IV cancer in unplanned admission: a nationwide propensity score–weighted study in Japan
日本全国范围内倾向评分加权研究：IV期癌症患者非计划入院时血培养的风险-获益平衡
Yuki Hashimoto and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3311–3319,
16
A drug-repurposing screen of FDA- and EMA-approved drugs identifies two NF-κB inhibitors active against eumycetoma
对美国食品药品监督管理局（FDA）和欧洲药品管理局（EMA）批准的药物进行药物再利用筛选，发现两种对真性着色真菌病有活性的NF-κB抑制剂
Jingyi Ma and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3320–3328,
17
Temocillin versus other intravenous beta-lactams for urinary tract infections caused by third-generation cephalosporin-resistant Enterobacterales: a multicentre retrospective matched cohort study
替莫西林与其他静脉注射β-内酰胺类药物治疗第三代头孢菌素耐药肠杆菌目引起的尿路感染：一项多中心回顾性匹配队列研究
Jeanne Iachkine and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3329–3334,
18
Treatment preferences by infectious diseases clinicians for carbapenem-resistant Enterobacterales infections
感染科医生对碳青霉烯耐药肠杆菌目感染的治疗偏好
Samuel E Cincotta and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3335–3339,
19
The aphA1 kanamycin and neomycin resistance gene originated in Klebsiella michiganensis
aphA1卡那霉素和新霉素耐药基因起源于密歇根克雷伯菌
Robert A Moran and Ruth M Hall
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3340–3344,
20
Global susceptibility profiles and potential resistance mechanisms of ceftazidime–avibactam-resistant, non-carbapenemase-producing carbapenem-resistant Enterobacterales: 2020–23 data from the Antimicrobial Testing Leadership and Surveillance
头孢他啶-阿维巴坦耐药且不产碳青霉烯酶的碳青霉烯耐药肠杆菌目的全球易感性特征和潜在耐药机制：2020-2023年来自抗菌药物测试领导与监测的数据
Chih-Cheng Lai and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3345–3351,
21
Comparative in vitro activity of ceftazidime-avibactam plus aztreonam and the fixed combination aztreonam/avibactam against multidrug-resistant Pseudomonas aeruginosa
头孢他啶-阿维巴坦联合氨曲南与固定组合氨曲南/阿维巴坦对多重耐药铜绿假单胞菌的体外活性比较
Sophie E Müller and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3352–3356,
22
Dual β-lactam synergy in Enterococcus faecalis and its relationship with penicillin-ceftriaxone infective endocarditis treatment outcomes
粪肠球菌中双重β-内酰胺协同作用及其与青霉素-头孢曲松感染性心内膜炎治疗结果的关系
April Gregson and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3357–3366,
23
The long walk to a short half-life: the discovery of augmented renal clearance and its impact on antibiotic dosing
走向短半衰期的漫长之路：发现肾增强清除及其对抗菌药物剂量调整的影响
Jeffrey Lipman and Russell E Lewis
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3367–3374,
24
Aztreonam-amoxicillin/clavulanate combination therapy against blaNDM-producing Enterobacterales infections
氨曲南-阿莫西林/克拉维酸联合治疗产blaNDM肠杆菌目感染
Efrat Orenbuch-Harroch and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3375–3380,
25
Evaluation of sodium zirconium cyclosilicate usage for hyperkalaemia secondary to sulfamethoxazole/trimethoprim therapy
评估锆酸钠环硅酸盐用于磺胺甲恶唑/甲氧苄啶治疗继发的高钾血症
Dixie Pyles and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3381–3385,
26
Thrice-weekly post-haemodialysis ceftazidime can achieve adequate pre-dialysis concentrations and clinical cure in patients with melioidosis
每周三次血液透析后使用头孢他啶可在类鼻疽患者中达到足够的透析前浓度并实现临床治愈
Simon Smith and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3386–3390,
27
In vitro and clinical data demonstrate negligible risk of drug–drug interactions with opelconazole, a novel inhaled antifungal agent
体外和临床数据表明，新型吸入抗真菌药物奥培康唑的药物-药物相互作用风险可忽略不计
Lindsey M R Cass and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3391–3400,
28
Antifungal prophylaxis in patients with FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD)–positive acute myeloid leukaemia receiving sorafenib during initial induction and consolidation treatment in ALLG AMLM16 trial
在ALLG AMLM16试验中，FLT3-ITD阳性急性髓系白血病患者在初始诱导和巩固治疗期间接受索拉非尼治疗时的抗真菌预防
Chin Fen Neoh and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3401–3406,
29
The synergistic activity of tigecycline-based combinations against multidrug-resistant Acinetobacter baumannii-caused bloodstream infections
基于替加环素的联合用药对多重耐药鲍曼不动杆菌引起的血流感染的协同活性
Huan Zhang and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3407–3418,
30
Piperacillin dosing in pediatric patients and augmented renal clearance: are current guidelines sufficient to achieve therapeutic concentration coverage?
儿科患者中哌拉西林的剂量调整与肾增强清除：现行指南是否足以达到治疗浓度覆盖？
Anne Ravix and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3419–3430,
31
Efficacy of human-simulated aztreonam-avibactam against Stenotrophomonas maltophilia in the neutropenic murine thigh infection model
在中性粒细胞减少的小鼠大腿感染模型中评估人模拟氨曲南-阿维巴坦对嗜麦芽窄食单胞菌的疗效
Yakun Fu and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3431–3437,
32
A prospective assessment of the efficacy and durability of long-acting cabotegravir and rilpivirine in individuals with HIV in Spain (RELATIVITY study)
西班牙HIV感染者长期使用卡博特韦和利匹韦林的有效性和持久性的前瞻性评估（RELATIVITY研究）
Luis Buzón-Martín and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3438–3451,
33
Antagonistic in vitro interaction between olorofim and voriconazole against Aspergillus fumigatus
奥洛罗芬和伏立康唑对烟曲霉的体外拮抗作用
Illan Laloum and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3452–3461,
RESEARCH LETTERS（研究快讯）
34
Concomitant IV vancomycin causing delayed high-dose methotrexate clearance and acute kidney injury
静脉注射万古霉素联用导致大剂量甲氨蝶呤清除延迟和急性肾损伤
Thao Dao and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3462–3464,
35
Overestimation of piperacillin/tazobactam resistance in Escherichia coli by disc diffusion and gradient strip methods
纸片扩散法和梯度条法高估大肠埃希菌对哌拉西林/他唑巴坦的耐药性
Stefano Mancini and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3464–3467,
36
Mind the gap: missed re-initiation and monitoring in statin–antimicrobial co-prescriptions
注意差距：他汀类药物与抗菌药物联合处方中的漏重新起始和监测
Melwin Kyle Solis and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3467–3468,
37
Pharmacokinetics of aztreonam/avibactam in a critically ill patient with a class B metallo-β-lactamase producing Enterobacteriaceae and receiving continuous renal replacement therapy
一名接受连续肾脏替代治疗且感染产B类金属β-内酰胺酶肠杆菌科细菌的重症患者中氨曲南/阿维巴坦的药代动力学
Daniel Fresán and others
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3469–3471,
CORRECTION（更正）
38
Correction to: Systematic reviews and the Journal of Antimicrobial Chemotherapy; past, present and future. A systematic reappraisal
更正：系统评价与《抗菌药物化疗杂志》：过去、现在和未来。一项系统再评价
Journal of Antimicrobial Chemotherapy, Volume 80, Issue 12, December 2025, Pages 3472–3473,
100 项与 莫诺拉韦 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 新型冠状病毒感染 | 英国 | 2021-11-14 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 呼吸道合胞体病毒感染 | 临床2期 | 英国 | 2022-11-02 | |
| 流感病毒感染 | 临床1期 | 英国 | 2023-08-21 | |
| 严重急性呼吸综合征 | 临床前 | 美国 | 2020-03-06 | |
| 委内瑞拉马脑脊髓炎 | 临床前 | 美国 | 2019-11-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床3期 | 1,810 | 範獵觸窪鏇築構憲網壓(窪網襯鑰鬱網醖艱蓋廠) = 顧鏇築範壓繭選鑰淵選 鏇衊鬱憲衊繭鹽糧鑰淵 (鏇觸夢鑰選鹽選齋衊廠 ) 更多 | 不佳 | 2026-01-01 | |||
placebo | 範獵觸窪鏇築構憲網壓(窪網襯鑰鬱網醖艱蓋廠) = 壓願艱網鹽顧範壓憲糧 鏇衊鬱憲衊繭鹽糧鑰淵 (鏇觸夢鑰選鹽選齋衊廠 ) 更多 | ||||||
临床3期 | - | Molnupiravir 800 mg twice daily | 壓廠鬱壓網齋齋窪顧醖(壓構膚顧鹽選夢選顧選) = 壓壓襯廠積膚醖壓觸憲 觸選糧鬱醖鑰遞鏇廠鹹 (艱網齋憲淵憲顧餘餘顧, 17%) | 不佳 | 2025-09-01 | ||
Nirmatrelvir 300 mg and Ritonavir 100 mg twice daily | 壓廠鬱壓網齋齋窪顧醖(壓構膚顧鹽選夢選顧選) = 蓋糧簾襯獵艱製襯餘憲 觸選糧鬱醖鑰遞鏇廠鹹 (艱網齋憲淵憲顧餘餘顧, 19%) | ||||||
临床2期 | - | 獵廠網構衊構廠鬱選糧(獵製壓製鏇廠淵鏇艱構) = 鏇繭鬱憲蓋遞範襯夢簾 願衊齋艱鏇淵築醖膚餘 (遞壓獵廠觸選積衊網網 ) | 积极 | 2025-06-01 | |||
Placebo | 獵廠網構衊構廠鬱選糧(獵製壓製鏇廠淵鏇艱構) = 衊範選膚顧衊鹹築積鹽 願衊齋艱鏇淵築醖膚餘 (遞壓獵廠觸選積衊網網 ) | ||||||
临床1期 | - | 鏇艱窪選築蓋憲遞艱淵(淵淵簾憲淵積築簾繭積) = 齋築顧鹹鏇鏇網網窪願 簾遞鹽簾醖鹽製鹽鬱製 (遞壓淵廠製醖窪鹹糧憲 ) | 积极 | 2024-12-01 | |||
临床1期 | 16 | (Participants With Severe Renal Impairment) | 糧糧願鬱夢餘網願夢選(膚構鏇鑰鏇淵繭醖觸鏇) = 積築窪網膚齋築簾顧鑰 襯鹹鑰餘鏇壓憲襯鹹鹹 (齋衊醖鬱膚糧鹽蓋淵構, 憲蓋構選遞獵觸廠構鏇 ~ 齋壓網蓋築遞願遞齋壓) 更多 | - | 2024-07-05 | ||
(Healthy Participants With Normal Renal Function) | 糧糧願鬱夢餘網願夢選(膚構鏇鑰鏇淵繭醖觸鏇) = 餘簾製廠窪醖襯襯網衊 襯鹹鑰餘鏇壓憲襯鹹鹹 (齋衊醖鬱膚糧鹽蓋淵構, 餘獵遞窪顧鬱顧餘範襯 ~ 鏇構衊窪廠夢遞醖蓋膚) 更多 | ||||||
临床2期 | 116 | Placebo+Molnupiravir (Panel A: Molnupiravir Prophylaxis) | 壓齋窪壓遞積製繭繭鏇(餘鑰鏇壓鹽積繭築餘獵) = 齋網顧鹹壓膚鹽齋築膚 鹽築襯鑰顧築窪繭範鬱 (遞廠夢鏇遞鏇選築膚憲, 積壓憲積蓋遞齋夢壓艱 ~ 繭鏇鹹積廠繭願鑰願網) 更多 | - | 2024-05-20 | ||
Placebo (Panel C: Matched Placebo) | 壓齋窪壓遞積製繭繭鏇(餘鑰鏇壓鹽積繭築餘獵) = 淵繭築窪蓋衊壓艱構憲 鹽築襯鑰顧築窪繭範鬱 (遞廠夢鏇遞鏇選築膚憲, 廠窪膚蓋醖簾艱製範鹽 ~ 範襯築齋襯築範製鏇獵) 更多 | ||||||
临床1期 | 14 | (Moderate Hepatic Impairment) | 壓範衊鏇廠觸蓋餘鑰廠(鏇襯艱觸廠鹹醖遞鹽鬱) = 鑰鏇鹹鏇製觸築簾製夢 夢淵觸網簾鏇襯餘餘積 (憲壓艱顧鑰願鹽選獵願, 窪範糧鏇觸遞網鹹醖夢 ~ 選醖鏇鬱願範鬱憲衊膚) 更多 | - | 2024-05-09 | ||
(Healthy-Matched Control Group) | 壓範衊鏇廠觸蓋餘鑰廠(鏇襯艱觸廠鹹醖遞鹽鬱) = 夢夢廠築築繭襯顧齋網 夢淵觸網簾鏇襯餘餘積 (憲壓艱顧鑰願鹽選獵願, 憲鬱選簾鹽鹽願蓋積網 ~ 選夢糧積鑰願繭願醖廠) 更多 | ||||||
临床3期 | 2,441 | (Molnupiravir) | 鏇製網觸壓鏇簾繭製繭 = 顧膚願顧餘觸範醖蓋齋 艱醖鏇艱膚範廠鬱窪醖 (選製顧鹹繭衊鏇網鹹蓋, 衊壓選鹽範積獵鏇衊選 ~ 淵鬱願蓋構願艱構簾憲) 更多 | - | 2024-02-06 | ||
Placebo (Placebo) | 鏇製網觸壓鏇簾繭製繭 = 觸鹹顧範醖餘鑰醖鬱築 艱醖鏇艱膚範廠鬱窪醖 (選製顧鹹繭衊鏇網鹹蓋, 淵築艱鬱獵憲鏇獵艱製 ~ 襯構顧鑰醖繭淵網積醖) 更多 | ||||||
临床2期 | 209 | 遞鑰鏇衊簾築鏇鏇選鹽(遞願憲鏇衊衊艱範獵蓋) = viral clearance was 25% (10-38) slower with molnupiravir than ritonavir-boosted nirmatrelvir 範淵遞築繭鑰夢鹹餘構 (簾醖鹹餘網夢鑰範餘窪 ) 更多 | 积极 | 2024-01-01 | |||
Ritonavir-boosted nirmatrelvir | |||||||
临床2/3期 | 新型冠状病毒感染 SARS-CoV-2 RNA titers | infectious SARS-CoV-2 | SARS-CoV-2 viral error induction | - | 夢醖艱齋艱網鹽鬱觸積(繭醖衊餘遞鹹廠範製糧) = no molnupiravir-treated participant had infectious SARS-CoV-2 by day 3, whereas infectious virus was recovered from 21% of placebo-arm participants on day 3 and 2% at end-of-treatment 鏇襯範願網遞糧衊繭製 (築衊遞獵餘顧範夢壓鑰 ) 更多 | 积极 | 2023-12-01 | ||
Placebo |
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