预约演示
更新于：2025-05-15
Nicoboxil/Nonivamide
烟波克昔/诺香草胺
更新于：2025-05-15
概要
基本信息
结构/序列
分子式C29H44N2O6 |
InChIKeyGBZLDDMGSWUIKV-UHFFFAOYSA-N |
CAS号93746-32-8 |
关联
2
项与 烟波克昔/诺香草胺 相关的临床试验NCT02300311
A Multinational, Randomised, Double-blind, Placebo-controlled, Parallel Group Study to Assess the Efficacy and Safety of Multiple Doses of Finalgon® Cream (1.08% Nicoboxil/ 0.17% Nonivamide) in the Treatment of Acute Low Back Pain
NCT01708915
A Multi-centre, Double-blind, Randomised, Parallel Group Study to Assess the Efficacy and Safety of Multiple Doses of Topically Applied Hyperemisation-inducing Ointment (2cm Ointment Line Per Application; up to 3 Times Daily for up to 4 Days) Containing 2.5% Nicoboxil/0.4% Nonivamide Versus 2.5% Nicoboxil, 0.4% Nonivamide and Placebo in Patients 18 to 65 Years of Age With Acute Low Back Pain
100 项与 烟波克昔/诺香草胺 相关的临床结果
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100 项与 烟波克昔/诺香草胺 相关的转化医学
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100 项与 烟波克昔/诺香草胺 相关的专利（医药）
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23
项与 烟波克昔/诺香草胺 相关的文献（医药）2021-11-01International journal of sports medicine4区 · 医学
No Influence of Nonivamide-nicoboxil on the Peak Power Output in Competitive Sportsmen
4区 · 医学
Article
作者: Schörkmaier, Theresa ; Wahl, Yvonne ; Wahl, Patrick ; Brinkmann, Christian ; Bloch, Wilhelm
Abstract:
Recent studies have shown that the oxygenated hemoglobin level can be enhanced during rest through the application of nonivamide-nicoboxil cream. However, the effect of nonivamide-nicoboxil cream on oxygenation and endurance performance under hypoxic conditions is unknown. Therefore, the purpose of this study was to investigate the effects of nonivamide-nicoboxil cream on local muscle oxygenation and endurance performance under normoxic and hypoxic conditions. In a cross-over design, 13 athletes (experienced cyclists or triathletes [age: 25.2±3.5 years; VO2max 62.1±7.3 mL·min−1·kg−1]) performed four incremental exercise tests on the cycle ergometer under normoxic or hypoxic conditions, either with nonivamide-nicoboxil or placebo cream. Muscle oxygenation was recorded with near-infrared spectroscopy. Capillary blood samples were taken after each step, and spirometric data were recorded continuously. The application of nonivamide-nicoboxil cream increased muscle oxygenation at rest and during different submaximal workloads as well as during physical exhaustion, irrespective of normoxic or hypoxic conditions. Overall, there were no significant effects of nonivamide-nicoboxil on peak power output, maximal oxygen uptake or lactate concentrations. Muscle oxygenation is significantly higher with the application of nonivamide-nicoboxil cream. However, its application does not increase endurance performance.
2016-05-01European Journal of Applied Physiology
Topical application of cream containing nonivamide and nicoboxil does not enhance the performance of experienced cyclists during a 4-km time-trial
Article
作者: Holmberg, Hans-Christer ; Zinner, Christoph ; Sperlich, Billy
PURPOSE:
Topical application of nonivamide-nicoboxil cream to resting legs has been shown to enhance the level of oxygenated haemoglobin in leg muscles 15 min later. Here, we examined whether such application improves the performance of experienced cyclists in a subsequent 4-km time-trial.
METHODS:
Nine male cyclists [26 ± 8 years; 176 ± 9 cm; 73.5 ± 12.8 kg; peak oxygen uptake: 50.7 ± 4.0 mL min(-1) kg(-1) (mean ± SD)] performed three 4-km time-trials on an ergometer with either topical application of nonivamide-nicoboxil cream (CREAM) or cream without active components (SHAM) to both their thigh muscles or no application (CONTROL).
RESULTS:
Only the skin temperature immediately before and after the time-trial was higher with cream than SHAM and CONTROL (best p < 0.001, best d = 1.16). All other parameters evaluated, i.e., the average power output during the time-trial (p > 0.05, best d = 0.08), the tissue saturation index of the m. vastus lateralis (p > 0.05, best d = 0.57), cardiac output, heart rate, oxygen uptake, blood lactate concentration, and perceived exertion (p > 0.05, best d = 1.1) were similar under all three conditions.
CONCLUSIONS:
Our present findings reveal that topical application of cream containing nonivamide and nicoboxil to the thighs of cyclists prior to a 4-km time-trial does not improve their power output, saturation of the m. vastus lateralis with oxygen, oxygen uptake, heart rate, cardiac parameters, or perceived level of exertion.
2016-02-01European journal of pain (London, England)2区 · 医学
Efficacy and safety of nicoboxil/nonivamide ointment for the treatment of acute pain in the low back – A randomized, controlled trial
2区 · 医学
Article
作者: Holm, C. ; Pisternick‐Ruf, W. ; Weiser, T. ; Richter, E. ; Gaubitz, M. ; Schiffer, T.
Abstract:
Background:
Until now, nonivamide/nicoboxil ointment has not been tested in a randomized trial for the treatment of acute non‐specific low back pain.
Methods:
This phase III randomized, double‐blind, active‐ and placebo‐controlled, multi‐centre trial investigated efficacy, safety and tolerability of topical nicoboxil 2.5%/nonivamide 0.4% for treatment of acute non‐specific low back pain [primary endpoint: pain intensity (PI) difference between pre‐dose baseline and 8 h after the first application].
Results:
Patients (n = 805), 18–74 years of age were treated for up to 4 days with nicoboxil 2.5%/nonivamide 0.4%, nicoboxil 2.5%, nonivamide 0.4% or placebo ointment. Pre‐dose baseline pain intensity (6.6 on a 0‐ to 10‐point numerical rating scale) was reduced by 1.049 points with placebo, by 1.428 points with nicoboxil, by 2.252 points with nonivamide and by 2.410 points with nicoboxil/nonivamide after 8 h (p < 0.0001 for nicoboxil/nonivamide vs. placebo, nicoboxil; p = 0.4171 for nicoboxil/nonivamide vs. nonivamide). At the end of treatment, the combination provided more pronounced PI reduction (3.540 points) compared with nicoboxil (2.371, p < 0.0001), nonivamide (3.074, p = 0.0259) and placebo (1.884, p < 0.0001). Low back mobility scores on Day 1 were better for the combination compared with all other treatments (p < 0.044); on Day 2–4, scores were better than for placebo and nicoboxil (p < 0.003). Patients assessed efficacy of the combination as greater than of the comparators (p ≤ 0.0129). All treatments were tolerated well. No treatment‐related serious adverse events were reported.
Conclusion:
Nicoboxil/nonivamide ointment is an effective, well‐tolerated medication for the treatment of acute non‐specific low back pain.
100 项与 烟波克昔/诺香草胺 相关的药物交易
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研发状态
临床结果
临床结果
适应症
分期
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临床3期 | 138 | placebo matching nonivamide + nicoboxil (Finalgon cream) | 築築繭蓋醖積壓窪鬱齋(製餘遞蓋壓艱願糧廠獵) = 鏇構鹽積淵鹹簾簾鑰顧 網選壓壓艱觸鑰醖願淵 (顧範鏇遞醖鏇餘壓餘膚, 0.215) 更多 | - | 2016-09-13 | ||
临床3期 | 138 | 顧壓艱願觸餘構廠繭製(觸鹹選築壓觸壓憲窪鹹) = 構齋繭範範範顧顧網築 糧鑰遞鑰衊衊願蓋廠積 (鏇積夢糧繭壓餘淵鹹膚 ) 更多 | 积极 | 2016-05-17 | |||
Placebo cream | 顧壓艱願觸餘構廠繭製(觸鹹選築壓觸壓憲窪鹹) = 衊廠築遞網鬱選襯顧製 糧鑰遞鑰衊衊願蓋廠積 (鏇積夢糧繭壓餘淵鹹膚 ) 更多 | ||||||
临床3期 | 805 | placebo matching nonivamide + nicoboxil (Placebo) | 範網糧蓋獵鹹衊網製築(鏇積獵網繭醖鹽膚衊鹹) = 構憲夢觸鹹範網壓願膚 廠淵網廠鹹壓觸獵艱醖 (齋鹽窪繭願構餘鹹築衊, 0.106) 更多 | - | 2014-05-15 | ||
(Nicoboxil) | 範網糧蓋獵鹹衊網製築(鏇積獵網繭醖鹽膚衊鹹) = 襯糧夢醖築鹹憲願鏇餘 廠淵網廠鹹壓觸獵艱醖 (齋鹽窪繭願構餘鹹築衊, 0.109) 更多 |
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