TQ-B3525

Advances in immunotherapy have ushered in a new era of treatment for follicular lymphoma (FL), particularly for patients who have experienced relapse after conventional chemotherapy regimens. This paradigm shift is characterized by the emergence of innovative therapies like CAR T-cell therapy and bispecific antibodies, which have demonstrated remarkable efficacy in targeting and eradicating lymphoma cells. CAR T-cell therapy represents a groundbreaking approach where a patient's own T-cells are genetically engineered to recognize and attack cancer cells. This personalized treatment has shown significant promise, especially for individuals who have undergone extensive previous therapies. One notable example is Axicabtagene ciloleucel (Yescarta), a CAR T-cell therapy approved for use in patients with relapsed or refractory follicular lymphoma. Clinical trials have highlighted its ability to induce durable remissions, with some patients experiencing long-term remission even after multiple prior therapies. LAS VEGAS, Nov. 28, 2024 /PRNewswire/ -- DelveInsight's ' Follicular Lymphoma Pipeline Insight 2024 ' report provides comprehensive global coverage of pipeline follicular lymphoma therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the follicular lymphoma pipeline domain. Key Takeaways from the Follicular Lymphoma Pipeline Report DelveInsight's follicular lymphoma pipeline report depicts a robust space with 50+ active players working to develop 55+ pipeline therapies for follicular lymphoma treatment. Key follicular lymphoma companies such as Chia Tai Tianqing Pharmaceutical Group, Incyte Corporation, Mabworks, Johnson & Johnson Innovative Medicine, Nektar Therapeutics, Xynomic Pharmaceuticals, Merck Sharp & Dohme, Jiangsu HengRui Medicine Co., Ltd., ADC Therapeutics, Bristol-Myers Squibb, Swedish Orphan Biovitrum, Zhejiang DTRM Biopharma, Immpact Bio, Galapagos, Immunitas Therapeutics, Enterome, CRISPR Therapeutics, CHO Pharma, Shanghai Blueray Biopharma, BeiGene, AstraZeneca, AVM Biotechnology, Mustang Bio, Merck, Pell Bio-Med Technology, Schrodinger Inc., Sana Biotechnology, Poseida Therapeutics, OncoNano Medicine, Inc., Nurix Therapeutics, Inc., NovalGen, Pfizer, Xencor, Wellington Zhaotai Therapies, MEI Pharma, Sutro Biopharma, Synthekine, Verismo Therapeutics, Vincerx Pharma, Novartis, Century Therapeutics, Newave Pharmaceuticals, Bio-Path Holdings, Affimed GmbH, Iksuda Therapeutics, Allogene Therapeutics, Adicet Bio, Carna Biosciences, Inc., BeiGene, Boryung Pharmaceutical, Accutar Biotechnology, Atara Biotherapeutics, AbbVie, InnoCare Pharma, NeoImmuneTech, and others are evaluating new follicular lymphoma drugs to improve the treatment landscape. Promising follicular lymphoma pipeline therapies such as Parsaclisib, TQ-B3525, Tafasitamab, MIL62, Ibrutinib, AZD0486, NKTR-255, Abexinostat, Acalabrutinib, Zilovertamab vedotin, SHR2554, Nivolumab, Loncastuximab tesirine, Golcadomide, Emapalumab, DTRM-555, Capivasertib, IMPT 314, GLPG5101, IMT-009, EO2463, CTX112, CHO-H01, BR1733, BGB-16673, BGB-10188, AZD5492, AVM0703, MB106, MK-1026, PL001, SGR-1505, SC291, SC262, P-CD19CD20-ALLO1, ONM 501, NX-5948, NX 2127, NVG-111, Mevrometostat, Plamotamab, WZTL-002, Voruciclib, STRO001, SYNCAR-001 + STK-009, SynKIR-310, VIP-152, VAY736, CNTY-101, LP-168, BP1002, IOA-244, IKS 03, ALLO-501, ADI-001, AS-1763, BGB-21447, BR101801, AC676, ATA3219, ABBV-319, ABBV-101, ICP-B02, ICP-B05, C-CAR039, Efineptakin Alfa, and others are under different phases of follicular lymphoma clinical trials. In August 2024, the company expects to file a supplemental Biologics License Application for tafasitamab for the treatment of patients with FL who have failed at least one prior systemic anti-CD20 immunotherapy or chemo-immunotherapy by the end of 2024 based on the positive Phase III results. In June 2024, a consortium of Eugene Private Equity and Korea Development Bank Private Equity announced that they would acquire 80% of South Korean vaccine maker Boryung Biopharma Co. for 320 billion won (USD 231 million). In February 2024, Incyte announced that it had entered into an asset purchase agreement with MorphoSys AG, which gives Incyte exclusive global rights for tafasitamab. Incyte will now recognize revenue and cost for all US commercialization and clinical development and MorphoSys will no longer be eligible to receive future milestone, profit split and royalty payments. In September 2023, OncoNano Medicine, Inc. announced a clinical trial supply agreement with Regeneron for the use of Libtayo (cemiplimab), a PD-1 inhibitor, in the combination stage of the first human trial of ONM-501, a dual-activating STING (STimulator of INterferon Genes) agonist and lead therapeutic development candidate. The ONM-501 first-in-human trial is a multicenter Phase Ia/b dose escalation and dose expansion study of intratumoral ONM-501 as monotherapy and in combination with Libtayo in patients with advanced solid tumors and lymphomas. OncoNano is the sponsor of the clinical trial, and Regeneron will supply cemiplimab. In May 2023, Janssen Pharmaceutical Companies of Johnson & Johnson announced that it had entered into a worldwide collaboration and license agreement with Cellular Biomedicine Group Inc. (CBMG) to develop, manufacture, and commercialize next-generation chimeric antigen receptor (CAR) T-cell therapies for the treatment of B-cell malignancies. Under the terms of the agreement, CBMG will grant Janssen a worldwide license to develop and commercialize the CAR-T assets, except in Greater China. Janssen and CBMG will negotiate an option for Janssen to commercialize the products in the Chinese territory. Janssen will make an upfront payment of USD 245 million that will be accounted for in the second quarter as a research and development expense. Additional future payments will be based upon achieving certain development, regulatory, and sales milestones, as well as tiered royalty payments on worldwide net trade sales, excluding Greater China. Request a sample and discover the recent advances in follicular lymphoma treatment drugs @ Follicular Lymphoma Pipeline Report The follicular lymphoma pipeline report provides detailed profiles of pipeline assets, a comparative analysis of clinical and non-clinical stage follicular lymphoma drugs, inactive and dormant assets, a comprehensive assessment of driving and restraining factors, and an assessment of opportunities and risks in the follicular lymphoma clinical trial landscape. Follicular Lymphoma Overview Follicular lymphoma is a common type of non-Hodgkin lymphoma (NHL) that originates from B-cells, a kind of white blood cell responsible for producing antibodies. This cancer is characterized by the growth of abnormal lymphoid follicles, which can disrupt normal lymphatic function. While the exact causes of follicular lymphoma are not fully understood, certain factors may increase the risk, including age (most commonly affecting adults over 60), a family history of lymphoma, and potential environmental factors such as exposure to pesticides or chemicals. Symptoms of follicular lymphoma can vary widely but may include painless swelling of lymph nodes in the neck, armpit, or groin, unexplained weight loss, night sweats, fatigue, and fever. Some patients may remain asymptomatic for extended periods, as this type of lymphoma can progress slowly. Diagnosis typically involves a combination of physical examinations, blood tests, imaging studies (like CT scans), and a biopsy of affected lymph nodes. The biopsy helps determine the subtype and stage of the lymphoma, which is crucial for planning treatment. Treatment for follicular lymphoma depends on the stage of the disease and the patient's overall health. Options may include watchful waiting for asymptomatic cases, chemotherapy, immunotherapy (such as monoclonal antibodies), and targeted therapies. In some cases, stem cell transplants may be considered for patients with more aggressive forms or those who do not respond to initial treatments. Given the indolent nature of follicular lymphoma, ongoing management, and regular monitoring are vital for achieving the best possible outcomes. Find out more about follicular lymphoma treatment drugs @ Drugs for Follicular Lymphoma Treatment A snapshot of the Follicular Lymphoma Pipeline Drugs mentioned in the report: Learn more about the emerging follicular lymphoma pipeline therapies @ Follicular Lymphoma Clinical Trials Follicular Lymphoma Therapeutics Assessment The follicular lymphoma pipeline report proffers an integral view of the follicular lymphoma emerging novel therapies segmented by stage, product type, molecule type, mechanism of action, and route of administration. Scope of the Follicular Lymphoma Pipeline Report Coverage: Global Therapeutic Assessment By Product Type: Mono, Combination, Mono/Combination Therapeutic Assessment By Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III Therapeutics Assessment By Route of Administration: Intra-articular, Intraocular, Intrathecal, Intravenous, Oral, Parenteral, Subcutaneous, Topical, Transdermal Therapeutics Assessment By Molecule Type: Oligonucleotide, Peptide, Small molecule Therapeutics Assessment By Mechanism of Action: Phosphatidylinositol 3 kinase delta inhibitors, Phosphatidylinositol 3 kinase gamma inhibitors, Emt protein-tyrosine kinase inhibitors, Interleukin 15 receptor agonists, Histone deacetylase inhibitors, Rad51 recombinase inhibitors, Agammaglobulinaemia tyrosine kinase inhibitors, Apoptosis stimulants, Cell cycle inhibitors, Tubulin inhibitors, Tubulin polymerisation inhibitors, Enhancer of zeste homolog 2 protein inhibitors, Antibody-dependent cell cytotoxicity, Programmed cell death 1 receptor antagonists, T lymphocyte stimulants, Alkylating agents, DNA cross-linking agents Key Follicular Lymphoma Companies: Chia Tai Tianqing Pharmaceutical Group, Incyte Corporation, Mabworks, Johnson & Johnson Innovative Medicine, Nektar Therapeutics, Xynomic Pharmaceuticals, Merck Sharp & Dohme, Jiangsu HengRui Medicine Co., Ltd., ADC Therapeutics, Bristol-Myers Squibb, Swedish Orphan Biovitrum, Zhejiang DTRM Biopharma, Immpact Bio, Galapagos, Immunitas Therapeutics, Enterome, CRISPR Therapeutics, CHO Pharma, Shanghai Blueray Biopharma, BeiGene, AstraZeneca, AVM Biotechnology, Mustang Bio, Merck, Pell Bio-Med Technology, Schrodinger Inc., Sana Biotechnology, Poseida Therapeutics, OncoNano Medicine, Inc., Nurix Therapeutics, Inc., NovalGen, Pfizer, Xencor, Wellington Zhaotai Therapies, MEI Pharma, Sutro Biopharma, Synthekine, Verismo Therapeutics, Vincerx Pharma, Novartis, Century Therapeutics, Newave Pharmaceuticals, Bio-Path Holdings, Affimed GmbH, Iksuda Therapeutics, Allogene Therapeutics, Adicet Bio, Carna Biosciences, Inc., BeiGene, Boryung Pharmaceutical, Accutar Biotechnology, Atara Biotherapeutics, AbbVie, InnoCare Pharma, NeoImmuneTech, and others. Key Follicular Lymphoma Pipeline Therapies: Parsaclisib, TQ-B3525, Tafasitamab, MIL62, Ibrutinib, AZD0486, NKTR-255, Abexinostat, Acalabrutinib, Zilovertamab vedotin, SHR2554, Nivolumab, Loncastuximab tesirine, Golcadomide, Emapalumab, DTRM-555, Capivasertib, IMPT 314, GLPG5101, IMT-009, EO2463, CTX112, CHO-H01, BR1733, BGB-16673, BGB-10188, AZD5492, AVM0703, MB106, MK-1026, PL001, SGR-1505, SC291, SC262, P-CD19CD20-ALLO1, ONM 501, NX-5948, NX 2127, NVG-111, Mevrometostat, Plamotamab, WZTL-002, Voruciclib, STRO001, SYNCAR-001 + STK-009, SynKIR-310, VIP-152, VAY736, CNTY-101, LP-168, BP1002, IOA-244, IKS 03, ALLO-501, ADI-001, AS-1763, BGB-21447, BR101801, AC676, ATA3219, ABBV-319, ABBV-101, ICP-B02, ICP-B05, C-CAR039, Efineptakin Alfa, and others. Dive deep into rich insights for new drugs for follicular lymphoma treatment, visit @ Follicular Lymphoma Drugs Table of Contents For further information on the follicular lymphoma pipeline therapeutics, reach out @ Follicular Lymphoma Treatment Drugs Related Reports Follicular Lymphoma Market Follicular Lymphoma Market Insights, Epidemiology, and Market Forecast – 2034 report deliver an in-depth understanding of the disease, historical and forecasted epidemiology, market share of the individual therapies, and key follicular lymphoma companies including Epizyme, Eisai, Bayer Healthcare Pharmaceuticals, Verastem Oncology, Gilead Sciences, TG Therapeutics, Bristol-Myers-Squibb, Roche, Incyte Corporation, Bristol Myers Squibb, ADC Therapeutics, MorphoSys, Nordic Nanovector, AbbVie, Regeneron Pharmaceuticals, Janssen Research & Development, Novartis, MEI Pharma, and BeiGene, among others. Non-Hodgkin Lymphoma Market Non-Hodgkin Lymphoma Market Insights, Epidemiology, and Market Forecast – 2032 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, market share of the individual therapies, and key Non-Hodgkin lymphoma companies, including Roche, Pfizer, Amgen, Novartis, Teva Pharmaceuticals, Genentech, ACD Therapeutics, among others. Non-Hodgkin Lymphoma Pipeline Non-Hodgkin Lymphoma Pipeline Insight – 2024 report provides comprehensive insights about the pipeline landscape, pipeline drug profiles, including clinical and non-clinical stage products, and the key Non-Hodgkin lymphoma companies, including Novartis, AstraZeneca, Genentech, BioInvent, Genmab, SystImmune, Nordic Nanovector, Pacylex Pharmaceuticals, Artiva Biotherapeutics, Inc., Chipscreen Biosciences, Ltd., Timmune Biotech Inc., Chia Tai Tianqing Pharmaceutical Group Co., Ltd., Gilead Sciences, Acerta Pharma BV, Adagene Inc, Conjupro Biotherapeutics, Inc., Rhizen Pharmaceuticals, Juventas Cell Therapy Ltd., Incyte Corporation, HUYA Bioscience International, SecuraBio, Genor Biopharma Co., Ltd., Kyowa Kirin Co., Ltd., Antengene Therapeutics Limited, Regeneron Pharmaceuticals, Jiangsu HengRui Medicine Co., Ltd., Xynomic Pharmaceuticals, Inc., BioTheryX, Inc., UWELL Biopharma, Kronos Bio, Bio-Thera Solutions, Spectrum Pharmaceuticals, Inc., Aptose Biosciences Inc., Miltenyi Biomedicine GmbH, Precision BioSciences, Inc., Teneobio, Inc., TCR2 Therapeutics, IGM Biosciences, Inc, among others. Diffuse Large B-cell Lymphoma Market Diffuse Large B-cell Lymphoma Market Insights, Epidemiology, and Market Forecast – 2034 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, market share of the individual therapies, and key DLBCL companies, including AbbVie, Genmab, Merck, Roche, Xencor, Janssen, Denovo Biopharma, Calithera Biosciences IMV, Biogen, Autolus Therapeutics, Allogene Therapeutics, Novartis, Miltenyi Biomedicine, Regeneron Pharmaceuticals, Debiopharm, Seagen, Takeda, AstraZeneca, Gilead Sciences, among others. About DelveInsight DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports pharma companies by providing comprehensive end-to-end solutions to improve their performance. Get hassle-free access to all the healthcare and pharma market research reports through our subscription-based platform PharmDelve . 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//   • FDA 2022年ODAC会议主张采用随机对照试验而非单臂试验作为血液瘤中PI3K抑制剂的申报依据； • PI3K抑制剂基于单臂试验获批仍有可能； • 安全问题在PI3K抑制剂中受到特别关注； • PI3K抑制剂与其他疗法联合应用值得进一步探索。 近来PI3K抑制剂再次引起热议。 今年6月，恒瑞医药林普利塞片的新适应症上市申请出现在药监局药品通知件中，意味着未获批准。该药成为继信达生物帕萨利司和正大天晴TQ-B3525片之后，第三款在中国上市受挫的PI3K抑制剂。 根据公开资料，这三项上市申请均基于单臂2期研究数据，其中林普利塞申报适应症为外周T细胞淋巴瘤（PTCL），后两者申报的则是滤泡性淋巴瘤（FL）。 “这可能是CDE参考了FDA的立场。”阿诺医药研发负责人谢毅钊博士在接受研发客采访时表示，“过去多款PI3Kδ抑制剂曾基于单臂试验中的ORR数据获批用于血液瘤，后又主动或被动撤回这些适应症。FDA已在2022年召开的肿瘤咨询委员会（ODAC）会议中指出，这些高水平的ORR并不一定最终能带来OS获益，并主张采用随机对照试验（RCT）而非单臂试验作为血液瘤中PI3K抑制剂的申报依据。” 海和药物副总裁张毅翔博士认为：“林普利塞、帕萨利司与TQ-B3525均靶向PI3Kδ，且申报适应症同为血液瘤。2022年ODAC会议中的共识可能会对此类产品有一定的影响”，“FL和PTCL适应症对应线数患者人群中，国内已获批药物的疗效和安全性也会对后续产品的审评带来一定影响。” 阿诺医药与海和药物均是PI3K抑制剂研发赛道的一员。前者正在全球开展泛PI3K抑制剂buparlisib治疗头颈部鳞状细胞癌（HNSCC）的多中心3期临床，目前已完成全部患者入组；后者的PI3Kα选择性抑制剂CYH33拟用于多种实体瘤等，针对复发/持续性卵巢、输卵管或原发性腹膜透明细胞癌的研究已进入2期临床阶段，在HR+/HER2-、PIK3CA突变的晚期乳腺癌患者中的研究即将进入3期关键临床阶段。 据研发客不完全统计，曾参与研发PI3K抑制剂的中国公司有近20家，但其中近一半产品被搁置，有些甚至已剔除出公司管线。仍在开发的产品则以实体瘤适应症为主。 左右滑动查看 还能考虑单臂试验吗？ 随着药监局审评要求收紧，未来单臂临床试验用于支持PI3K抑制剂上市还有希望吗？张毅翔给出的答案是肯定的。 “FDA并不是对所有PI3K抑制剂的单臂试验说不。2022年FDA召开的ODAC会议共识仅限于PI3K抑制剂在血液瘤中的应用，如果新一代PI3K抑制剂表现出强效低毒的特征，也并不一定会受限于上述共识。此外，ODAC会议中也进行了澄清，FDA批准的PI3Kα抑制剂alpelisib，并不在会议讨论范围。”她说。 早在2019年5月，alpelisib就获得FDA批准用于HR+/HER2-携带PIK3CA突变的晚期转移性乳腺癌，成为首个获批实体瘤的PI3K抑制剂。2022年4月，该药又基于真实世界研究数据获得FDA加速批准，用于PIK3CA相关过度生长综合症（PROS）成人和2岁及以上儿童患者。 那么，什么样的PI3K抑制剂能够凭借单臂临床试验数据获批上市？ “这需要满足监管机构关于单臂试验的相关指导原则，能解决未满足的临床需求且获益风险比高的药物仍会有机会。”张毅翔表示。根据指导原则，单臂试验支持药物上市适用于患者无有效治疗选择，试验药物机制明确、疗效突出、安全性风险可控，对照组疗效数据明确，罕见病的情况。 拓展阅读  CDE收紧单臂临床试验申请 回过头来看国内上市受挫的三款PI3K抑制剂，它们的遭遇或许早已有迹可循。尤其在已有3款PI3K抑制剂获批的FL领域，后来者想要基于单臂试验获批的可能性几乎为零。即便花大力气完成确证性3期研究并获批，未来产品的商业化价值也要重新考量。 数据显示，FL约占所有非霍奇金淋巴瘤（NHL）病例的10%～20%，中国每年新发病例不足2万。 “虽然FL是一个小众适应症，但如果产品可以做到全球前三，机会还是有的。如果不是，在竞争对手的先发优势下，后来者几乎没什么潜力，尤其在中国，新药的价格和利润都很低。”谢毅钊说。 信达生物也曾在2023年9月发布的公告中提到，其帕萨利司申报的r/r FL适应症患者群体较小、市场竞争较为激烈。基于产品价值等多方考虑后，该公司决定主动撤回该产品在中国的上市申请。 如何克服毒性问题 一直以来，安全问题在PI3K抑制剂开发中受到特别关注，一些产品上市便伴有多项黑框警告，严重且致命的不良反应还会令患者OS受损。 在谢毅钊看来，“PI3K抑制剂大部分的毒性都是On-target off-tumor（非肿瘤靶向毒性），这很难避免。” 因为PI3K信号通路在许多正常细胞中扮演着重要角色，参与调节细胞的增殖、凋亡与分化等生理过程。并且，不同PI3K家族成员有不同的生理作用，针对不同亚型的选择性抑制剂，在副作用方面也有很大不同。比如PI3Kδ的毒性偏向于肝毒性和胃肠道反应，PI3Kα偏向高血糖和皮肤反应等。 但这并不意味着PI3K抑制剂的终结。 以阿诺医药为例，虽然知晓buparlisib在乳腺癌试验中因高毒性被诺华放弃，但公司仍引进该产品，之后将研发方向聚焦于HNSCC。 “HNSCC是一个临床需求严重未满足的治疗领域，患者在接受PD-1/L1抑制剂治疗后几乎没有其它标准治疗方法，他们的需求更多是延长生命，因此对新药毒性的容忍度比较高。相比之下，乳腺癌患者对毒性的接受度低很多，很多人经过多种治疗后已经能够正常工作与生活。”谢毅钊说。 拓展阅读  阿诺医药：收购诺华PI3K抑制剂并非孤注一掷 谁能改变全球头颈鳞癌治疗格局 海和药物的策略则是聚焦药物有竞争力的适应症，并进行稳健的剂量探索，确定临床获益风险比最佳剂量。 “FDA ODAC会议中已指出，PI3Kδ抑制剂在血液肿瘤的开发中存在剂量探索不足的问题，这也可能是导致OS受损的原因。因此，需要通过稳健的剂量探索来确定在不同的适应症、不同的药物联用情况下获益风险平衡比最佳的剂量。”张毅翔说。 她同时还提到，突变型PI3K亚型选择性抑制剂的开发也可能解决靶点相关的毒性问题，但其疗效还需等待临床试验的验证。 未来的研发方向 事实上，不同亚型的PI3K抑制剂潜在获益人群也有所不同，比如PI3Kα抑制剂治疗该靶点相关突变的肿瘤、泛PI3K抑制剂治疗头颈癌、PI3Kδ/γ抑制剂治疗淋巴瘤、PI3Kβ抑制剂治疗前列腺癌等。其中，受访者最看好的当属PI3Kα。 研究表明，编码PI3Kα催化亚基的PIK3CA基因是癌症中最常见的突变基因之一，该突变在多种恶性肿瘤中均有发现且比例较高（约10%~40%）。因此PI3Kα抑制剂可用于治疗PIK3CA基因突变驱动的多种实体瘤，适应症更为广泛。 当下，首款PI3Kα抑制剂alpelisib不仅斩获乳腺癌和PROS适应症，而且取得商业化成功。诺华财报显示，该产品2023年全球销售额达到5亿美元，同比增长35%。 另一款来自罗氏的PI3Kα抑制剂inavolisib（伊那利塞）也已在3期临床中取得积极结果，其联合CDK4/6抑制剂哌柏西利和雌激素受体拮抗剂氟维司群，可将一线PIK3CA突变乳腺癌患者的PFS翻倍。 在张毅翔看来：“PI3Kα抑制剂与其它抗肿瘤药物的联合用药是未来开发的重要方向之一，尤其与免疫疗法的联用值得探索。” 采访中，谢毅钊同样提及联合用药的概念。 “一直以来，PI3K抑制剂单药治疗面临较大的挑战，这可能与系统的反馈机制有关。当PI3K的活性受到抑制时，系统其它信号通路会很快将其回调至原有水平，这也是过去很多PI3K抑制剂疗效不足的原因。”他进一步表示，“未来，PI3K抑制剂与其它针对不同信号通路的产品联用更有可能成功，比如与免疫检查点抑制剂的联合使用，或者开发双靶点抑制剂，不过前提是两个靶点之间不能存在毒性的重叠。” 编辑 | 姚嘉 yao.jia@PharmaDJ.com  总第2177期 访问研发客网站，深度报道和每日新闻抢鲜看 www.PharmaDJ.com