预约演示
更新于：2026-09-04
Fostemsavir Tromethamine
磷坦姆沙韦
更新于：2026-09-04
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2020-07-02), |
最高研发阶段(中国)- |
特殊审评快速通道 (美国) |
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结构/序列
分子式C29H37N8O11P |
InChIKeyRRGJSMBMTOKHTE-UHFFFAOYSA-N |
CAS号864953-39-9 |
关联
26
项与 磷坦姆沙韦 相关的临床试验NCT07393659
A Phase 3b, Open-label, Multicenter, Continued Access Study for Participants Transitioning From ViiV Healthcare Sponsored or ViiV Healthcare Collaborative Parent Studies for HIV Treatment
The purpose of this study is to provide continued access to the study treatment for participants from previous ViiV Healthcare studies who are still benefiting from it and do not have local access after completing the parent study. This continued access will also allow further collection of safety data. Eligible participants are those who completed a ViiV Healthcare-sponsored or collaborative parent study and are currently experiencing clinical benefit. The Sponsor will periodically review the study to consider other treatment access options.
开始日期2026-07-21 |
申办/合作机构 |
NCT07030920
Reducing Systemic Inflammation in People on Antiretroviral Therapy
This randomized, open-label clinical trial will evaluate whether adding fostemsavir to current antiretroviral therapy can reduce the risk of cardiovascular disease in people with well-controlled HIV. Researchers will compare imaging, clinical and biomarker outcomes between participants who receive fostemsavir in addition to their existing treatment and those who continue with standard care alone.
开始日期2025-09-30 |
申办/合作机构 |
NCT07053384
An Exploratory Phase 1b, Multicenter, Randomized, Open-Label Study to Investigate the Impact of the Administration of Intravenous VH3810109 With or Without Oral Fostemsavir in Combination With Integrase Inhibitor-Based Antiretroviral Therapy on the Viral Reservoir in Adults Living With HIV-1
This study investigates the use of VH3810109 with or without FTR to reduce the size and activity of the HIV viral reservoir in two sub-populations of people living with HIV: treatment-naïve adults (Population 1) and treatment-experienced adults currently taking a standard of care (SOC) integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) regimen (Population 2). The study is designed to include the following phases: Randomized Intervention Phase (Step 1), Analytical Treatment Interruption (ATI) Phase (Step 2), and Follow-up Phase (Step 3).
开始日期2025-07-10 |
申办/合作机构 |
100 项与 磷坦姆沙韦 相关的临床结果
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100 项与 磷坦姆沙韦 相关的转化医学
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100 项与 磷坦姆沙韦 相关的专利（医药）
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169
项与 磷坦姆沙韦 相关的文献（医药）2026-08-01·AIDS PATIENT CARE AND STDS
People with HIV Continuing on Complex Regimens in the Era of Treatment Optimization: Characteristics and Outcomes
Article
作者: Sax, Paul E. ; McEwen, Isobel ; Eron, Joseph J. ; Benson, Paul ; Park, Seojin ; Ruhs, Sebastian ; Santiago, Steven ; Radtchenko, Janna ; Walworth, Charles ; Gandhi-Patel, Bhumi ; Ramgopal, Moti ; Dunn, Keith J. ; Mounzer, Karam ; Elion, Richard A.
While once-daily single-tablet regimens (STRs) are recommended for most people with human immunodeficiency virus (HIV; PWH), some require complex antiretroviral (ARV) regimens due to resistance, contraindications, or drug–drug interactions. We characterized PWH who were virologically suppressed on complex regimens (VS on CR) in a U.S. cohort to inform treatment optimization as new switch options emerge. This retrospective study analyzed electronic medical records from the Trio Health HIV Network and genotypic resistance data from Labcorp. We included PWH ≥ 18 years who were virologically suppressed (viral load [VL] < 200 copies/mL) at complex regimen initiation between January 2016 and November 2023, with ≥6 months from last prescription and ≥1 year of follow-up. Complex regimens included ≥2 of 3 core ARV classes concomitantly, more than once-daily dosing, multi-tablet regimens (MTRs) not replaceable by STRs, or resistance to two ARV classes. Virologic failure (VF) was defined as VL ≥ 500 copies/mL or two consecutive VLs ≥ 200 copies/mL. PWH on ibalizumab, fostemsavir, or lenacapavir were excluded to reflect standard clinical practice. Of 43,236 PWH with ARV prescriptions, 3,320 (8%) were VS on CR. Among these, 69% were on MTRs, 43% used ≥2 core ARV classes, and 11% had resistance to two classes. The median age was 52 years, and 77% were male. Common comorbidities included obesity (69%), neuropsychiatric disorders (35%), and cardiovascular disease (33%). Regimens predominantly included protease inhibitors (77%), nucleoside reverse transcriptase inhibitors (75%), and integrase strand transfer inhibitors (57%). Over a median 2.2-year follow-up, 4% experienced VF. Approximately 8% of PWH on ART remain VS on CR, underscoring the need for education on regimen optimization and novel treatment options for those unable to simplify their therapy.
2026-03-01·HIV MEDICINE
Exploring the impact of baseline and on‐treatment variables on durability of responses to fostemsavir through weeks 96 and 192 in the phase 3
BRIGHTE
study
Article
作者: Krystal, M. ; Du, F. ; Wang, X. ; Li, B. ; Pierce, A. ; Gartland, M. ; Tenorio, A. R. ; Castillo‐Mancilla, J. R. ; Liao, Q.
Abstract:
Objectives:
The gp120‐directed attachment inhibitor fostemsavir was effective in people with multidrug‐resistant (MDR) HIV‐1 in the BRIGHTE study. Understanding factors associated with virologic response can help clinicians optimize treatment and identify individuals for fostemsavir‐based regimens. In previous multivariable analyses, baseline CD4+ T‐cell count, baseline log
10
HIV‐1 RNA and temsavir plasma concentration were associated with virologic response through 24 weeks. This expanded analysis evaluated predictors of the durability of response at Weeks 96 and 192.
Methods:
BRIGHTE participant data (Randomized Cohort [RC],
n
= 272; Non‐randomized Cohort,
n
= 99) were evaluated to examine baseline factors associated with virologic outcomes (HIV‐1 RNA <40 copies/mL [Snapshot]; protocol‐defined virologic failure [PDVF]) using linear/logistic regression with stepwise selection. A separate analysis evaluated baseline factors for association with treatment‐adherent PDVF.
Results:
In RC participants, higher baseline log
10
HIV‐1 RNA, lower number of fully active available antiretrovirals in initial optimized background therapy (OBT) and a lower overall susceptibility score to newly used antiretrovirals in initial OBT were associated with lower odds of virologic response at Week 96. Baseline gp120 substitutions and dolutegravir use were additional factors through Week 192. Other baseline factors, including CD4+ T‐cell count <20 cells/mm
3
, HIV‐1 RNA ≥100 000 copies/mL, antiretroviral therapy duration >20 years or gp120 substitutions, had low predictive value for treatment‐adherent PDVF in RC participants (Week 96, 35%; Week 192, 39%).
Conclusions:
Multivariable analysis (MVA) identified several factors predictive of virologic response. No baseline factors were highly predictive of virologic failure at Weeks 96 or 192. Findings support the use of fostemsavir in diverse populations with MDR HIV‐1.
2026-02-18·JOURNAL OF INFECTIOUS DISEASES
Fostemsavir Decreases the Levels of Anti-gp120 CD4-Induced Antibodies in Heavily Treatment-Experienced People With HIV
Article
作者: Tolbert, William D ; Castagna, Antonella ; Finzi, Andrés ; Clark, Andrew ; Durand, Madeleine ; Prakash, Manyu ; Richard, Jonathan ; Clemente, Tommaso ; Chandravanshi, Monika ; Benlarbi, Mehdi ; Bourassa, Catherine ; Pazgier, Marzena
Abstract:
Background:
Heavily treatment-experienced (HTE) people with HIV (PWH) have limited antiretroviral therapy (ART) treatment options, putting them at greater risk of unfavorable human immunodeficiency virus 1 (HIV-1) disease progression. Fostemsavir (BMS-663068) efficiently suppressed viremia and increased CD4 count when combined with other antiretrovirals in HTE PWH. Its active metabolite, temsavir (BMS-626529, GSK2616713), binds a conserved pocket within the envelope glycoprotein (Env) CD4 binding site and prevents CD4-induced conformational changes. Temsavir effect on Env conformation profoundly alters its glycosylation and cleavage, thereby modifying its antigenicity and reducing gp120 shedding. Here we evaluated if fostemsavir treatment in PWH modulated the levels of nonneutralizing gp120 CD4-induced (CD4i) antibodies (Abs) associated with CD4 depletion in vitro and in PWH.
Methods:
We measured the levels of anti-gp120 CD4i Abs in plasma samples taken before and after fostemsavir treatment in HTE participants from the BRIGHTE trial and the PRESTIGIO registry and compared them to those of a control ART-treated group from the SAILING trial.
Results:
We observed a significant decline of anti-gp120 CD4i Abs in the 2 fostemsavir-treated HTE groups, but not in the control group. Moreover, this effect was unique to anti-gp120 CD4i Abs, as no significant changes were observed in the levels of antibodies targeting Gag. Functionally, this decline in CD4i Abs was associated with a reduced capacity of plasma to recognize and eliminate uninfected primary CD4+ T cells coated with soluble gp120.
Conclusions:
Altogether, fostemsavir may provide additional immune benefits to PWH, beyond blocking viral entry, by reducing anti-gp120 CD4i Abs levels.
Clinical Trials Registration:
NCT04098315, NCT01231516, and NCT02362503.
36
项与 磷坦姆沙韦 相关的新闻（医药）2026-08-18
点击下方，关注作者
第14期科学前沿速递
2026-08-19
栏目介绍
“一周科学前沿”栏目每周将分享1-2篇生命科学领域的前沿研究文献及研究进展，客观梳理其核心机制和研究结论。
希望能为大家在繁忙的科研工作之余，提供一份了解不同领域前沿动态的简明参考。
1
前言
每次新发病毒出现，抗病毒药物研发几乎都要从头开始：面对一种全新的病原体，研究者往往需要重新筛选成千上万个化合物，才能确定少数几个候选先导化合物——过程周期长、成本高，也难以在疫情暴发的关键时间窗口内提供有效应对方案。
此前我们介绍过不少作用机制明确、已经走到动物实验甚至临床阶段的抗病毒候选药（比如阻断麻疹样病毒传播的GHP-88310。该文章的详细内容可点击以下链接进行回看：【前沿速递】Nat. Microbiol.：口服广谱抗病毒药GHP-88310可阻断麻疹样病毒的接触与空气传播），但这些工作的起点，通常都要追溯到更早期、更少被关注的一个环节：如何从数十万乃至上亿的化合物库中，筛选出真正值得推进湿实验验证的候选化合物。这一环节，正是机器学习虚拟筛选发挥作用的关键所在。
2025年6月，美国国立卫生研究院（NIH）旗下国家转化科学促进中心（NCATS）团队在Nature旗下期刊《Communications Chemistry》发表了一项研究：将此前较少被系统纳入机器学习筛药流程的病毒基因组序列信息，与化合物结构信息相结合训练预测模型，同时构建了“病毒选择性”和“广谱抗病毒”两套模型，并将其应用于36万个化合物的虚拟筛选，最终挑选346个化合物进行湿实验验证。
2
研究背景
现实压力
据世界卫生组织统计，截至2024年5月30日，新冠疫情已在全球造成超过700万人死亡，据原文表述，其经济代价占全球医疗卫生支出的85.91%、全球GDP的9.13%。与此同时，病毒的持续进化不断削弱现有疗法的效力：艾滋病治疗中，高效抗逆转录病毒疗法（HAART）虽然显著改善了患者预后，但逆转录酶抑制剂的长期广泛使用也催生了耐药HIV毒株；而埃博拉、尼帕病毒等病原体，至今仍缺乏有效的抗病毒药物，部分原因在于制药企业的商业策略考量与技术门槛。
传统机器学习虚拟筛选的局限
计算机辅助药物设计（CADD）尤其是机器学习虚拟筛选，近年来已成为加速抗病毒药物发现的重要手段：支持向量机（SVM）、随机森林（RF）、极端梯度提升（XGBoost）等算法常被用来从已知抗病毒化合物中提取特征、预测新化合物的抗病毒活性，从而缩小实验筛选范围。
但作者指出，现有方法存在几个共性局限：
其一，多数模型仅针对单一靶点或单一病毒，假阳性率较高；
其二，模型输入通常只包含化合物结构或分子描述符这一类信息，较少纳入病毒靶蛋白序列、结构等同样重要的信息；
其三，很多研究只用单一算法建模，难以捕捉数据中多样的潜在模式；
其四，多数模型是“病毒专属”的，缺乏应对新发病毒株、变异株的灵活性，而这恰恰是快速演化的病原体（如流感病毒）最棘手的地方。
为解决这些问题，研究团队提出了一个新的集成框架：不再局限于预先设定的单一病毒靶点，而是同时利用化合物结构信息和病毒基因组序列信息，既能识别针对单一病毒的“选择性抑制剂”，也能识别对多种病毒都有效的“广谱抗病毒剂”；并通过多种算法的共识预测，弥补单一算法的局限。
团队将这一框架应用于预测潜在的抗SARS-CoV-2化合物，并进一步用体外实验加以验证。
3
研究方法
数据构建
团队从GISAID、EBI、NCBI三个数据库获取了10种人类致病病毒共32个毒株、变异株的完整基因组序列。分析显示，同一病毒不同毒株间的基因组高度保守（例如8个SARS-CoV-2毒株、变异株间序列一致性>94%），但不同病毒之间差异巨大（例如SARS-CoV-2与丙肝病毒HCV之间序列一致性<26%）。
同时，团队从NCATS内部数据库和DrugBank数据库整理出303个已获批或在研抗病毒药物（AIADs），对应378组“药物-病毒”有效组合。不同病毒对应的药物数量差异很大：少至2个（如抗乙型流感、抗HPV药物），多至96个（抗HCV药物），中位数为每种病毒20个。
303种药物与10种病毒理论上可组成3030种组合，其中已知有效的378组被标记为“阳性”，其余2652组标记为“阴性”，构成模型训练的基础数据集。
图1 病毒选择性抗病毒药物的分析与建模
引自原文Fig. 1: A为10种病毒32个毒株间基因组两两相似性热图，可见同病毒毒株高度聚类（橙色），不同病毒间差异明显（绿色）；B为已获批/在研抗病毒药物在各病毒间的分布；C为特征构建流程图——化合物结构经KNIME平台转为1024位ECFP4指纹，病毒基因组序列经fastText转为100维向量，二者拼接为整合特征；D为五种机器学习算法的模型性能对比，RF和XGB表现最佳。
病毒基因组的“语言化”表示（本研究的技术亮点）
如何把长度不一、由A/T/C/G四种碱基组成的病毒基因组，转换成机器学习模型能理解的数值向量？团队借用了自然语言处理的思路：把整条基因组序列看作一句“话”，把每连续6个碱基组成的片段（6-mer）看作一个“单词”，再用FastText词嵌入模型学习“核苷酸词袋”表示。这与训练词向量模型理解人类语言中单词的语义关系，本质上是同一套数学工具。最终，无论原始基因组长度如何，都被统一转换成一个100维的数值向量。
化合物结构一侧则采用更成熟的1024位ECFP4分子指纹表示。两类特征拼接后，共同作为下游分类模型的输入特征。
两套模型、五种算法
团队分别构建了两类模型：
（1）“病毒选择性”模型融合化合物结构指纹与病毒基因组向量，用于预测某化合物对某一特定病毒是否有效；
（2）“广谱抗病毒”模型仅使用化合物结构指纹，将303个已知抗病毒药物（阳性）与385个“非细胞毒性药物”（NCPCs，来自Tox21细胞活力筛选中至少30/55项实验呈非活性的已上市药物，作为阴性对照）区分开来。以上这一设计基于一个假设：抗病毒药物在有效浓度下往往伴随一定细胞毒性，而普通非抗病毒药物则不然。
两类模型均采用朴素贝叶斯（NB）、支持向量机（SVM）、神经网络（NNET）、随机森林（RF）、极端梯度提升（XGB）五种算法分别建模，数据按70%训练/30%测试划分，重复20次以保证结果稳健，并通过特征选择与数据重平衡进一步优化。
图2 广谱抗病毒药物的分析与建模
引自原文Fig. 2:A为385个非细胞毒性药物（NCPCs）在Tox21细胞活力实验中的活性分布；B为抗病毒药物与NCPCs之间的Tanimoto结构相似度分析，显示两组化合物结构上确有区分度；C为五种算法的模型性能对比，RF和SVM表现最佳（AUC-ROC均>0.83。
虚拟筛选与湿实验验证流程虚拟筛选与湿实验验证流程
团队设计了五步筛选流程，从NCATS内部约36万个化合物库中逐层过滤潜在的抗SARS-CoV-2候选物：
第一步，化合物需同时被RF和XGB（病毒选择性模型）预测为阳性，且对8个SARS-CoV-2毒株、变异株（原始株及alpha、beta、delta、gamma、lambda、mu、omicron）中至少4个预测有效；
第二步，需同时被SVM和RF（广谱抗病毒模型）预测为阳性；
第三步，与83个已知抗SARS-CoV-2药物中至少一个结构相似（maxTC>0.25），以确保化合物落在模型的“适用域”内；
第四步，通过基于化合物结构训练的细胞毒性QSAR模型（5种算法中至少3种预测无毒）；
第五步，用k-means算法将候选化合物聚类为100组，以保证入选化合物的结构多样性、排除已测试或库中不可得的化合物。
4
研究发现
虚拟筛选流程与化合物分布
经过细胞毒性QSAR模型评估，36万化合物中共有4595个被识别为潜在抗SARS-CoV-2化合物，其中3857个（84%）预测为非细胞毒性、738个（16%）预测有细胞毒性。
经过结构多样性聚类和可得性筛选后，最终346个化合物进入湿实验验证：256个用于假病毒颗粒（PP）侵入抑制实验，128个用于RNA依赖性RNA聚合酶（RdRp）活性抑制实验。
图3 抗SARS-CoV-2候选药物的虚拟筛选全流程
引自原文Fig. 3: A为五步筛选流程示意图（病毒选择性模型→广谱抗病毒模型→结构相似性过滤→细胞毒性过滤→结构多样性聚类）；B为非细胞毒性（NCAC，84%）与细胞毒性（CAC，16%）候选化合物的比例；C为二者的结构相似度分析；D为细胞毒性QSAR模型的性能评估，RF表现最佳。
湿实验命中率
在PP侵入抑制实验中，256个化合物里有24个被验证为阳性，命中率9.4%；其中两个化合物潜力突出：NCGC00014029（IC₅₀ = 1.31 ± 0.32 μM）和NCGC00166392（IC₅₀ = 1.37 ± 0.00 μM），效力均在1微摩尔级别。
在RdRp抑制实验中，128个化合物里有47个被验证为阳性，命中率高达37%，明显高于PP实验；其中最强的NCGC00014952 IC₅₀低至3.83 μM。
作为参照，传统高通量筛选的化合物命中率通常在1%以下，两组实验的命中率都明显高于这一基准，说明模型预测确实起到了有效的“预筛选”作用。
图4 代表性SARS-CoV-2 PP侵入抑制剂的浓度-反应曲线
引自原文Fig. 4: 展示了6个代表性PP侵入抑制剂的剂量-反应曲线及化学结构，蓝色为抗病毒活性（PP），灰色为细胞毒性对照（TOX）；其中NCGC00014029与NCGC00166392的IC₅₀均小于2 μM。
“意外发现”交叉验证了模型可靠性：
在RdRp实验的阳性化合物中，azeliragon（NCGC00506876）值得特别关注。这是一款已知的晚期糖基化终末产物受体（RAGE）小分子拮抗剂，此前文献已报道其能降低单核细胞对SARS-CoV-2颗粒的内化摄取；本研究中它在RdRp实验中被验证为阳性（IC₅₀ = 7.68 ± 0.62 μM），进一步支持了其潜在抗病毒活性，也从侧面印证了模型预测的可靠性。
另一个值得关注的例子是glaziovine（NCGC00408842）——一款已知通过抑制乙肝表面抗原（HBsAg）分泌而发挥抗乙肝病毒（HBV）活性的化合物（HepG2.2.15细胞中IC₅₀=8.0 μM）。
本研究首次发现它对SARS-CoV-2 RdRp也有抑制活性（IC₅₀=10.49±3.36 μM）。这相当于把它的抗病毒谱系从HBV扩展到了SARS-CoV-2。除去这两个已知化合物和其余四个有生物活性记录但未知抗病毒功能的化合物，剩下的20个PP侵入抑制剂和41个RdRp抑制剂此前均无任何已知的生物活性报道，属于全新的潜在先导化合物。
图5 代表性SARS-CoV-2 RdRp抑制剂的浓度-反应曲线
引自原文Fig. 5: 展示了6个代表性RdRp抑制剂的剂量-反应曲线及化学结构，包括本文重点提及的azeliragon（NCGC00506876，IC₅₀=7.68 μM）
4
讨论与展望
与同类研究的印证
作者提到，Deepthi等人此前曾用结合化合物结构与病毒基因组数据的深度学习集成模型进行SARS-CoV-2药物重定位研究，五折交叉验证AUC-ROC达0.89。该研究与本研究的结果相互印证，共同支持了“化合物结构+病毒基因组信息”整合建模这一路径在抗病毒药物发现中的有效性。
此外，团队对广谱抗病毒模型识别出的85个在抗病毒药物中显著富集的结构特征做了解读，发现它们与已知抗病毒药效团高度吻合：核苷、核苷酸类似物（如广谱抗RNA病毒药利巴韦林中的尿嘧啶结构）、含氮杂环（如抗HIV药物fostemsavir中的吡咯、抗SARS冠状病毒氯喹中的喹啉）、磷酸基团（如抗多种疱疹病毒药物西多福韦）、腈基（如抗SARS-CoV-2候选药PF-07304814）等。这种结构层面的可解释性，为模型预测的合理性提供了额外支持。
局限性
作者也坦诚指出了几点局限：
其一，对于训练数据中样本量较小的病毒（如乙型流感、HPV各自仅有2个已知抗病毒药物），模型识别选择性抗病毒药物的准确性可能受限；
其二，PP侵入实验和RdRp实验各自只能捕捉病毒生命周期中的部分环节——PP实验缺乏完整病毒基因组背景，难以完全模拟真实感染动态；RdRp实验只针对病毒复制这一环节，可能遗漏通过调节宿主免疫反应、干扰病毒组装或释放等其他机制起效的化合物；而模型训练所用的抗病毒药物本身，也并非全部通过这两种机制发挥作用，这意味着真实命中率可能被这两种特定实验的检测范围所低估。
其三，也是最关键的一点：目前所有验证均停留在体外细胞和酶学实验层面，距离真正的候选药物，还需要系统的体内药效学、药代动力学/药效学表征，以及相关动物模型中的安全性评估。
5
结论
这项研究证明，把病毒基因组序列信息（而不只是化合物结构）纳入机器学习模型，可以同时兼顾“病毒选择性”和“广谱抗病毒”两种药物发现需求；将其应用于36万化合物的虚拟筛选后，两种体外实验分别取得了9.4%和37%的命中率，明显优于传统高通量筛选的效率基准，其中azeliragon、glaziovine两个已知药物的“意外阳性”也为模型可靠性提供了交叉验证。
这套框架的价值不仅在于筛出的71个阳性化合物本身，更在于其方法论上的可扩展性——原则上，只要获得新病毒的基因组序列，就可以将其快速纳入模型重新训练，为应对下一次新发病毒威胁提供更快的计算响应速度。团队已将模型代码开源（GitHub: TX-2017/antivirals_prediction），供同行验证与复用。
文献信息：
Xu, T., Xu, M., Zhang, Q., Chen, C.Z., Zheng, W. & Huang, R. Leveraging viral genome sequences and machine learning models for identification of potentially selective antiviral agents. Communications Chemistry 8, 189 (2025).
DOI: 10.1038/s42004-025-01583-2
延伸阅读：
模型代码与数据（GitHub开源）：https://github.com/TX-2017/antivirals_prediction
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工具推荐
本上述文中，研究团队将病毒基因组序列转化为数值向量、与化合物结构特征整合建模，本质上是在解决“结合预测”与“功能预测”之间的鸿沟，即化合物与靶点之间是否存在关联，以及这种关联在生物学层面究竟指向激活还是抑制。
类似的方法论问题，同样是中医药网络药理学研究长期以来的瓶颈：即便计算出化合物与靶点存在结合关系，也往往无法判断该结合产生的效应方向。
中医药系统药理学平台TCMSP 9.01近期上线的“靶标激活、抑制双向评估”模块，正是针对这一问题的解决方案。该模块基于多视图深度学习架构，以化合物SMILES序列与靶蛋白氨基酸序列为输入，输出该药物-靶点对的功能方向预测，试图在计算层面上补全“结合”与“功能”之间的信息缺口。
平台同时集成了虚拟敲除、PPI蛋白互作分析、分子对接等工具，覆盖“成分-靶点-网络-功能-结构”的完整分析链条。
目前平台面向公众号读者限时免费开放体验：
平台地址：https://next.tcmsp-e.com/ai-agent
注册链接：https://next.tcmsp-e.com/register?ref=COCH046
邀请码：COCH046（限时有效）
此外，添加TCMSP官方微信（17392526548），备注"朝花难拾矣推荐"，可申请一个月平台免费会员权限，同步领取模块操作手册与示例数据集。
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2026-07-27
·新浪看点
2025年，是人类与艾滋病等重大感染性疾病漫长斗争中的一个关键年份。这一年，科学与临床的边界被不断拓宽，一系列突破性进展不仅巩固了我们将艾滋病转变为可管理慢性病的成就，更以前所未有的清晰度，勾勒出从“长期控制”迈向“功能性治愈”甚至“彻底清除”的未来蓝图。本年度十大科技进展，集中体现了这一领域的深刻变革：治疗目标正从抑制病毒升级为修复机体与根除隐匿库；治疗策略日趋简化与长效，从每日服药迈向半年一次的预防与注射；对疾病的理解深入到细胞与基因的微观世界，揭示了病毒潜伏的“神经暗道”与精英控制者免疫系统的制胜密码；临床管理哲学则从“粗放标准”转向“个体化精准”，在重症感染的拔管、透析乃至器官功能评估等核心环节，提供了更安全、高效的新选择。这些跨越基础研究、药物开发与临床实践的里程碑，共同指向一个更清晰的目标：为患者提供负担更轻、生活质量更高、且最终可能摆脱终身治疗的全新解决方案。以下，我们将为您详细解读这十项重塑格局的年度突破。 一、长效疗法成为主流，半年一次给药成为现实长效抗逆转录病毒疗法（ART）在治疗和预防方面均取得里程碑式进展。在治疗方面，卡博特韦/利匹韦林长效注射剂已获批，可实现每1-2个月给药一次。在预防方面，首个也是目前唯一获批的每半年给药一次的长效暴露前预防（PrEP）药物——HIV-1衣壳抑制剂来那卡帕韦（Lenacapavir）展现出卓越的预防效果，临床试验显示其有效性超过99.9%，为无法坚持每日服药的人群提供了变革性的选择。二、靶向新机制的抗病毒药物不断涌现针对HIV生命周期新靶点的药物研发活跃。来那卡帕韦作为首个衣壳抑制剂，通过干扰病毒衣壳组装和分解发挥强效抗病毒作用，为多重耐药患者提供了关键解决方案。此外，成熟抑制剂（如Zabofiravir）和附着抑制剂（如Fostemsavir）等新型药物也在临床开发中，进一步丰富了治疗武器库。三、对“精英免疫者”免疫机制的深入理解1.流行病学新发现：在刚果（金）等高流行地区，精英控制者的比例（2.7%-4.3%）显著高于全球平均水平（约0.5%），提示在自然选择压力下，人群可能进化出更强的天然抗病毒能力。2.细胞免疫的核心机制：精英控制者的CD8⁺ T细胞如同“特种部队”，具有超常的战斗力与独特的代谢程序，能高效识别并清除被感染的细胞。研究已实现在实验室中将普通感染者的CD8⁺ T细胞重编程，使其获得类似的抗病毒能力。3.病毒库的“基因囚笼”效应：关键研究发现，精英控制者体内的HIV病毒更倾向于整合到基因组的转录“沙漠地带”（如19号染色体的特定异染色质区）。这种不利位置使病毒处于深度休眠状态，形成了天然的“基因监狱”，揭示了病毒库的质量（整合位点）而非数量是实现控制的关键。4.先天免疫因子的作用：研究发现TRIM5α蛋白在精英控制者体内活性更高，能有效识别并触发针对HIV衣壳的细胞内防御。增强该蛋白的活性被视为一种潜在的新型治疗策略。5.临床启示与治疗范式转变：自愈案例改写指南：如洛伦·威伦伯格等“清除性治愈”案例的出现，证明了人体免疫系统在极少数情况下能彻底清除HIV，这促使医学界重新评估对精英控制者一律进行药物治疗的传统建议。转化治疗方向：基于上述机制，两大转化研究方向正在推进：一是利用CRISPR等基因编辑技术将病毒序列“放逐”到基因组休眠区；二是通过免疫细胞重编程，为普通患者制造“精英化”的超级免疫细胞。四、司美格鲁肽改善HIV感染者认知功能的新发现1.核心发现：2025年一项2b期临床试验表明，GLP-1受体激动剂司美格鲁肽在已接受稳定治疗、病毒受抑的HIV感染者中，能显著改善视觉空间、语言和记忆等认知功能。2.关键机制：认知改善效应独立于药物的减肥作用，与体内炎症标志物（如高敏C反应蛋白）水平下降直接相关，提示其抗炎特性是带来认知获益的主要途径。3.研究背景与意义：随着HIV感染者寿命延长，认知障碍成为突出的长期并发症。此研究为管理这一难题提供了全新、有潜力的药物干预思路，拓展了司美格鲁肽的应用前景。4.当前局限：该发现尚属初步，结论有待更大规模、更长周期的研究验证，目前不推荐常规用于改善认知。五、HIV长效治疗现突破：短期雷帕霉素干预为抗体基因治疗铺平道路2025年11月发表于《自然-通讯》的一项研究，在实现HIV一次性治愈的抗体基因治疗道路上取得了关键突破。该研究成功解决了长期阻碍该领域发展的核心难题——宿主免疫系统产生的抗药物抗体（ADA）会清除治疗性抗体，导致治疗失败。研究团队创新性地采用了一种已获批的免疫抑制剂雷帕霉素（西罗莫司）进行短期干预。在通过腺相关病毒（AAV）载体递送编码广谱中和抗体（如3BNC117）的基因前后，对实验动物短期使用雷帕霉素，以暂时抑制驱动ADA产生的T细胞反应。结果表明，这一策略能有效诱导免疫耐受。在恒河猴实验中，高达80%（12/15）的动物在雷帕霉素停药后，实现了治疗性抗体的长期稳定表达，且未产生显著的ADA反应，成功率相比此前不足10%的数据实现了飞跃性提升。这项研究的意义在于，它没有采用复杂的基因工程，而是利用一种现有药物，通过短暂的、可控的免疫抑制窗口，为长效基因治疗的长期表达“铺平了道路”。这一策略不仅为HIV功能性治愈研究提供了新的可行路径，其“短期免疫抑制护航长效基因治疗”的范式，也可能为其他遗传病或慢性病的AAV载体治疗提供重要借鉴。六、首个无整合酶双药疗法效果显著，预计明年上市2025年11月，默克公司宣布其研发的每日一次口服双药HIV治疗方案——多拉韦林/伊斯拉韦（DOR/ISL）在3期临床试验中取得关键成果，标志着HIV简化治疗的重要进展。该方案是首个不含整合酶抑制剂的双药疗法，由非核苷逆转录酶抑制剂多拉韦林和新型核苷逆转录酶易位抑制剂（NRTTI） 伊斯拉韦组成。在一项针对537名初治成年感染者的研究中，DOR/ISL在第48周时的病毒抑制率与当前标准三药方案（必妥维）相比达到了非劣效性主要终点，即在保证疗效相当的前提下，进一步减少了用药种类。其核心成分伊斯拉韦因出色的效力和耐药屏障成为研发重点。美国FDA已正式受理该药物的上市申请，预计将于2026年4月底前做出审评决定。该方案不仅为初治患者提供了更简化的选择，也为已获病毒抑制且希望优化治疗方案的患者提供了新选项。值得关注的是，伊斯拉韦同时是两款周口服长效方案的研发核心，预示着未来治疗将向更长间隔、更低用药负担的方向持续发展。七、科学家首次清晰捕捉HIV病毒利用神经通路在体内“潜行”与“再分布”，揭秘其无法根除的关键原因2025年10月发表于《美国病理学杂志》的一项研究，揭示了艾滋病病毒（HIV/SIV）在体内长期潜伏和再分布的一条关键“暗道”，为根治病毒提出了全新挑战与方向。该研究颠覆了传统上认为中枢神经系统（大脑和脊髓）是相对独立“免疫孤岛”的认知。通过向感染SIV的猴子脑脊液中注入荧光标记的纳米颗粒，研究人员首次清晰“追踪”到，吞噬了病毒的中枢神经系统巨噬细胞，能够沿着颅神经与周围神经的路径迁移到全身。这一发现意义重大：它证明大脑不仅是重要的病毒储存库，更是一个活跃的“中转站”。即使在抗病毒药物的强力压制下，潜伏在大脑中的病毒仍可借助这条“神经高速路”，不断向背根神经节、外周神经等全身其他组织进行“病毒再播种”，并维持慢性炎症。这直接解释了为何病毒难以被彻底根除。该研究为未来的治愈策略指明了关键：要实现HIV的根治，未来的治疗方案可能不仅需要清除血液和常规组织中的病毒，还必须考虑如何阻断这条连接大脑与全身的神经通路，从而切断病毒潜伏与复发的核心逃逸路径。八、肥胖危重症患者拔管新方案：低剂量去甲肾上腺素（近期发表于《重症监护医学》的一项研究，为肥胖危重症患者的机械通气撤离提供了突破性循证依据，挑战了传统临床常规。该研究通过双队列设计（纳入1400余名肥胖及2300余名非肥胖患者）证实：拔管时使用低剂量去甲肾上腺素（这一发现具有直接的临床颠覆意义：它打破了“必须完全停用血管升压药才能拔管”的传统教条，表明轻度的血流动力学支持（低剂量去甲肾上腺素）并非拔管的绝对禁忌证。这有助于避免因等待血压完全稳定而导致的机械通气时间不必要的延长，从而减少呼吸机相关并发症，优化医疗资源使用。研究的局限性在于人群以短期通气的外科患者为主，对长期通气的内科重症患者的普适性仍需验证。未来临床实践需进行多维度评估，在严格监测呼吸功能达标的同时，可审慎地将低剂量血管支持纳入拔管决策框架，推动个体化、精准化的拔管策略。九、需透析的AKI（AKI-D） 患者新选择：保守策略让肾功能恢复快 6.5 天，还更加安全近期发表于《美国医学会杂志》的LIBERATE-D随机对照试验，为需透析的急性肾损伤患者的治疗策略提供了颠覆性的新证据。这项多中心研究纳入了220名血流动力学稳定的AKI-D患者，将他们随机分为两组：一组采用传统的“每周三次”标准透析（常规组），另一组仅在出现明确代谢或临床指征（如高钾血症、严重酸中毒等）时才进行透析（保守组）。研究结果显示，保守性透析策略显著改善了患者的肾脏预后：与常规组相比，保守组患者出院时实现肾功能恢复的比例更高（64.2% vs 50.5%），并且肾功能恢复的中位时间缩短了6.5天。同时，保守组患者每周接受的透析次数中位数显著减少（1.8次 vs 3.1次），且未增加严重不良事件的风险，透析相关低血压的发生次数也更少。该研究挑战了长期以来的临床常规，其核心机制在于，减少不必要的频繁透析可以避免肾脏因治疗过程而遭受反复的“医源性缺血损伤”和炎症激活，从而为肾小管细胞的自我修复创造了更有利的生理环境。这项研究标志着AKI-D的管理正从“一刀切”的标准化模式，向基于患者个体状况的精准化、保守化策略转变。它为临床医生在面对特定患者群体时，提供了一种能加速肾功能恢复、减少治疗负担且安全的新选择。十、SOFA 评分 30 年首更：334 万患者验证，ICU 器官评估新标来了重症医学领域的基础评估工具——序贯器官衰竭评估（SOFA）评分，在问世近30年后迎来了首次重大更新。基于全球9个国家、超过334万ICU患者的数据验证，新版SOFA-2评分通过“专家共识+大数据驱动”的模式，构建了更贴合当代临床实践的器官功能评估新标准。此次更新的核心突破在于解决了旧版评分与当前高级生命支持技术脱节的问题。SOFA-2将体外膜肺氧合（ECMO）支持、基于精确剂量的血管活性药物分层（如明确去甲肾上腺素不同剂量区间的评分）以及高级呼吸支持模式等现代ICU常规干预手段纳入评估体系。同时，它对格拉斯哥昏迷评分（GCS）、胆红素和肌酐等传统指标的阈值进行了优化与简化，使评分分布更合理，减少了旧版中部分中间分值患者比例极低的失真现象。验证结果显示，SOFA-2在预测ICU死亡率方面效能略有提升，且在不同经济水平和医疗资源配置的地区均表现出良好的适用性与稳定性。这一更新标志着器官功能障碍评估进入了一个更精准、标准化和全球化的新时代，将为重症医学的临床诊疗、科研和质量控制提供更为可靠的工具。
2026-06-30
The Journal of Infectious Diseases. Volume 233 Issue 1
传染病杂志 233卷 1期
https://academic.oup.com/jid/issue/
Editorial（社论）
1
Virulent Bacteriophages for Controlling Shiga Toxin–Producing Escherichia coli (STEC) Without Inducing Toxin Production
用于控制产志贺毒素大肠杆菌（STEC）且不诱导毒素产生的烈性噬菌体
Glen D Armstrong
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 1–2, https://doi.org/10.1093/infdis/jiaf036
Invited Perspective（特邀观点）
2
With All Good Intentions: How CDC Decisions Harmed Science and People
John Weiser
好心办坏事：美国疾控中心（CDC）的决策如何损害了科学和民众
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 3–5, https://doi.org/10.1093/infdis/jiaf584
Perspectives（观点）
3
Persistence Is Resistance: The Fight to End the HIV Epidemic Hangs in the Balance
坚持即抵抗：结束艾滋病流行的斗争悬而未决
Colleen F Kelley and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 6–8, https://doi.org/10.1093/infdis/jiaf389
Special Collection on Contemporary Research on Antimicrobial Resistance（抗菌药物耐药性当代研究特辑）
Call for Papers: Antimicrobial Resistance（征稿启事：抗菌药物耐药性）
4
How Pooled Procurement Can Expand Access to Novel Antibacterial Therapeutics Globally
集中采购如何在全球范围内扩大新型抗菌疗法的可及性
Jessica Swenson
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 9–15, https://doi.org/10.1093/infdis/jiaf370
5
Pharmacokinetics and Safety of Clofazimine in Women With Rifampicin-resistant Tuberculosis During Pregnancy and the Postpartum Period: Results From IMPAACT P1026s
妊娠期及产后利福平耐药结核病女性患者使用氯法齐明的药代动力学和安全性：IMPAACT P1026s研究结果
Jennifer A Hughes and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 16–26, https://doi.org/10.1093/infdis/jiaf504
6
Emergence of ST3390: A Novel Apigmented MRSA Clone From the CC5 Lineage
ST3390的出现：源自CC5谱系的一种新型非色素性耐甲氧西林金黄色葡萄球菌克隆
Emily A Felton and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 27–37, https://doi.org/10.1093/infdis/jiaf410
7
Establishing a Practical Approach to Sewer Monitoring for Antimicrobial Resistance Genes and Organisms at Healthcare Facilities
建立医疗机构针对抗菌药物耐药基因和耐药菌的污水监测实用方法
Rachel S Poretsky and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 38–48, https://doi.org/10.1093/infdis/jiaf434
8
Real-world Prevalence of Nonintegrase INSTI Resistance-Associated Mutations and Virological Outcomes in People Who Have Recently Acquired HIV-1 in the United Kingdom
英国近期感染HIV-1人群中非整合酶INSTI耐药相关突变的现实流行率及病毒学结果
Christine Kelly and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 49–58, https://doi.org/10.1093/infdis/jiaf500
9
Detection of Carbapenem-Resistant Bacteria in Skilled Nursing Facility Wastewater
在专业护理机构废水中检测碳青霉烯类耐药细菌
Susanna Lenz and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 59–69, https://doi.org/10.1093/infdis/jiaf534
10
Investigating Azithromycin Activity Against ESBL-Producing Escherichia coli Under Physiologically Relevant Conditions
在生理相关条件下研究阿奇霉素对产超广谱β-内酰胺酶大肠杆菌的活性
Sean Jung and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 70–75, https://doi.org/10.1093/infdis/jiaf480
ID Translational Science Update（传染病转化医学更新）
11
Planning and Analyzing a Low-Biomass Microbiome Study: A Data Analysis Perspective
低生物量微生物组研究的规划与分析：数据分析视角
George I Austin and Tal Korem
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 76–86, https://doi.org/10.1093/infdis/jiae378
Major Articles and Brief Reports（主要论著和简短报告）
Bacterial Disease Pathogenesis（细菌性疾病发病机制）
12
Virulent Bacteriophages for Controlling Shiga Toxin–Producing Escherichia coli Without Inducing Toxin Production
用于控制产志贺毒素大肠杆菌（STEC）且不诱导毒素产生的烈性噬菌体
Eunshin Cho and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 87–95, https://doi.org/10.1093/infdis/jiaf035
13
Hygromycin A Treatment of Borrelia burgdorferi–Infected Peromyscus leucopus Suggests Potential as a Reservoir-Targeted Antibiotic
对伯氏疏螺旋体感染的白足鼠使用潮霉素A治疗，提示其作为针对储存宿主抗生素的潜在作用
Stephanie S You and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 96–100, https://doi.org/10.1093/infdis/jiaf363
14
Low Intrinsic Killing Activity and no Impact of Its Positivity on Phase 3 Pneumococcal Vaccine Adult Studies
固有杀菌活性低，且其阳性对3期肺炎球菌疫苗成人研究无影响
Weifeng Xu and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 101–111, https://doi.org/10.1093/infdis/jiaf427
15
Population Structure of Escherichia coli Isolated From the Human Bloodstream, Human and Animal Feces, and the Environment in Northern Tanzania
坦桑尼亚北部从人体血液、人和动物粪便以及环境中分离出的大肠杆菌的种群结构
Deng B Madut and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 112–121, https://doi.org/10.1093/infdis/jiaf437
Viral Disease Pathogenesis（病毒性疾病发病机制）
16
Evaluating the Breadth and Reliability of Influenza Vaccine Protection Indicators: A Secondary Analysis of an Animal Challenge Trial
评估流感疫苗保护指标的广度和可靠性：动物挑战试验的二次分析
Yao Lu and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 122–131, https://doi.org/10.1093/infdis/jiaf331
17
Assessing the Transmissibility and Outbreak Risk of Measles in the United States, 2024–2030
评估2024 - 2030年美国麻疹的传播性和暴发风险
Subekshya Bidari and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 132–136, https://doi.org/10.1093/infdis/jiaf342
18
Coronavirus Disease 2019 Risk in Patients With Autoimmune Diseases Using Biologics or Small Molecules: A Population-Based Cohort Study
使用生物制剂或小分子药物治疗的自身免疫性疾病患者感染2019冠状病毒病的风险：一项基于人群的队列研究
Eun Mi Song and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 137–147, https://doi.org/10.1093/infdis/jiaf347
19
Leveraging Lyme Disease Surveillance to Simulate Powassan Virus Prevalence
利用莱姆病监测来模拟伯氏疏螺旋体脑炎病毒流行率
James M McCluskey and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 148–152, https://doi.org/10.1093/infdis/jiaf368
20
Human Metapneumovirus–, Respiratory Syncytial Virus–, and Influenza-Associated Pneumonia Hospitalizations in Colorado Adults Aged ≥50 Years, 2016–2023
2016 - 2023年科罗拉多州50岁及以上成年人中与人类偏肺病毒、呼吸道合胞病毒和流感相关的肺炎住院情况
Eric A F Simões and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 153–163, https://doi.org/10.1093/infdis/jiaf381
Malaria Disease Pathogenesis（疟疾发病机制）
21
Digital PCR Reveals High PvDBP1 but not PvEBP/DBP2 and PvRBP2b Copy Number in Plasmodium vivax From Duffy-Negative Individuals in Central Africa
数字PCR显示，在非洲中部杜菲血型阴性个体中，恶性疟原虫的PvDBP1拷贝数高，但PvEBP/DBP2和PvRBP2b拷贝数不高
Bernis Neneyoh Yengo and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 164–172, https://doi.org/10.1093/infdis/jiaf322
22
Elevated Soluble Urokinase-Type Plasminogen Activator Receptor Levels, Organ Dysfunction, and Death in Children Hospitalized With Malaria: Considerations for Use as a Risk Stratification Tool
疟疾住院儿童中可溶性尿激酶型纤溶酶原激活物受体水平升高、器官功能障碍和死亡：作为风险分层工具的考量
Charles Ssuuna and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 173–177, https://doi.org/10.1093/infdis/jiaf327
23
Vaccine-Induced Antibodies to a C-Terminal Plasmodium falciparum Circumsporozoite Protein Epitope Associated With Protection Against Malaria Challenge
疫苗诱导产生的针对疟原虫环子孢子蛋白C端表位的抗体与对疟疾挑战的保护作用相关
DeAnna J Friedman-Klabanoff and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 178–190, https://doi.org/10.1093/infdis/jiaf391
24
Cytokines Associated With Moderate and Severe Adverse Events During a Sporozoite Malaria Vaccine Trial With Controlled Human Malaria Infection
在受控人体疟疾感染的孢子虫疟疾疫苗试验中，与中度和重度不良事件相关的细胞因子
Lauren P Jatt and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 191–196, https://doi.org/10.1093/infdis/jiaf435
Global Health（全球健康）
25
HIV and Syphilis Coinfection in Pregnancy and Adverse Birth Outcomes in Uganda
乌干达妊娠期HIV和梅毒合并感染与不良出生结局
Mehal Churiwal and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 197–205, https://doi.org/10.1093/infdis/jiaf453
26
Antibodies to Tick Salivary Antigens AV422 and Calreticulin in Patients With Spotted Fever Group Rickettsioses and Other Febrile Illnesses in Northern Tanzania
坦桑尼亚北部斑点热群立克次体病及其他发热性疾病患者体内针对蜱唾液抗原AV422和钙网织蛋白的抗体
Ganga S Moorthy and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 206–215, https://doi.org/10.1093/infdis/jiaf506
27
Virological Tools Fail to Properly Identify “Unusual” Hepatitis C Virus Subtypes Resistant to Direct-Acting Antiviral Drugs in The Gambia
病毒学工具未能正确识别冈比亚对直接抗病毒药物耐药的“罕见”丙型肝炎病毒亚型
Erwan Vo-Quang and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 216–220, https://doi.org/10.1093/infdis/jiaf378
Major Articles and Brief Reports（主要论著和简短报告）
Public Health（公共健康）
28
A Framework for Assessing the Opportunity for Advanced Research, Development, and Regulatory Approval of Medical Countermeasures: A Component of BARDA's Emerging Infectious Diseases Strategy
评估医疗对策先进研究、开发和监管批准机会的框架：生物医学高级研究与发展管理局（BARDA）新兴传染病战略的组成部分
Richard C White and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e1–e10, https://doi.org/10.1093/infdis/jiaf486
Bacterial Disease Pathogenesis（细菌性疾病发病机制）
29
Prevalence of Candidate Vaccine Targets and Genomic Features of Pediatric Invasive Streptococcus Agalactiae in Japan
日本儿科侵袭性无乳链球菌候选疫苗靶点的流行率及基因组特征
Masashi Kasai and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e11–e21, https://doi.org/10.1093/infdis/jiaf491
30
Daptomycin-Loaded Nanocarriers Facilitate Synergistic Killing of Methicillin-Resistant Staphylococcus aureus via Lipid-Mediated Interactions and Targeting
载达托霉素纳米载体通过脂质介导的相互作用和靶向作用促进对耐甲氧西林金黄色葡萄球菌的协同杀伤
Jhih-Hang Jiang and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e22–e33, https://doi.org/10.1093/infdis/jiaf492
31
Comparing Respiratory Illness Surveillance Case Definitions to Detect Bordetella pertussis in Children Aged <5 Years With Respiratory Illness in South Africa, 2017–2023
Kate Bishop and others
比较呼吸道疾病监测病例定义以检测2017 - 2023年南非5岁以下呼吸道疾病患儿中的百日咳博德特氏菌
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e34–e43, https://doi.org/10.1093/infdis/jiaf501
32
Insights on Recurrent and Sequential Clostridioides difficile Infections From Genomic Surveillance in Minnesota, USA, 2019–2021
2019 - 2021年美国明尼苏达州基因组监测对复发性及序贯性艰难梭菌感染的见解
Daniel Evans and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e44–e54, https://doi.org/10.1093/infdis/jiaf505
33
Single-Cell Transcriptome Profiling Reveals the Immune Dysregulation Characteristics of Mice Infected With Brucella abortus
单细胞转录组分析揭示感染牛布鲁氏菌小鼠的免疫失调特征
Guangzhi Zhang and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e55–e66, https://doi.org/10.1093/infdis/jiaf522
34
Culture and Adaptation of Pseudomonas aeruginosa During Early Infection in Children With Cystic Fibrosis
囊性纤维化患儿早期感染期间铜绿假单胞菌的培养与适应
Sumitra D Mitra and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e67–e76, https://doi.org/10.1093/infdis/jiaf527
Viral Disease Pathogenesis（病毒性疾病发病机制）
35
Hyperendemicity of Rift Valley Fever in Southwestern Uganda Associated With the Rapidly Evolving Lineage C Viruses
乌干达西南部裂谷热高度流行与快速进化的C谱系病毒相关
Barnabas Bakamutumaho and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e77–e88, https://doi.org/10.1093/infdis/jiaf417
36
Relative Effectiveness of High-Dose Versus Standard-Dose Influenza Vaccination Against Hospitalizations and Deaths According to Frailty Score: A Post Hoc Analysis of the DANFLU-1 Randomized Trial
根据衰弱评分比较高剂量与标准剂量流感疫苗对住院和死亡的相对有效性：DANFLU - 1随机试验的事后分析
Caroline Espersen and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e89–e98, https://doi.org/10.1093/infdis/jiaf420
37
Emergence of Two New Lineages of the Cosmopolitan Dengue Virus Serotype 2 in Yunnan, China, 2024
2024年中国云南出现两种新的全球流行性登革热病毒2型谱系
Man Li and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e99–e108, https://doi.org/10.1093/infdis/jiaf422
38
Cerebrospinal Fluid Immune Cell Alterations in Women With Neuropsychiatric Long COVID
神经精神性新冠长期症状女性患者脑脊液免疫细胞改变
Benjamin Orlinick and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e109–e117, https://doi.org/10.1093/infdis/jiaf468
39
The Role of Enoxaparin in Influenza Virus Infections and its Therapeutic Implications
依诺肝素在流感病毒感染中的作用及其治疗意义
Marta Bermejo-Jambrina and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e118–e131, https://doi.org/10.1093/infdis/jiaf470
40
Monkeypox Virus Shedding Despite Tecovirimat Treatment in a Cohort in Toronto, Canada
加拿大多伦多一队列中接受特考韦瑞治疗后猴痘病毒仍排出的情况
Jacklyn R Hurst and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e132–e139, https://doi.org/10.1093/infdis/jiaf471
41
Disentangling Temporal Trends of Clade Ib Monkeypox Virus Transmission in Burundi
厘清布隆迪Ib支系猴痘病毒传播的时间趋势
Shihui Jin and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e140–e144, https://doi.org/10.1093/infdis/jiaf475
42
Profiling Human Papillomavirus Lineage-Specific Capsid Antigenicity With Geographically Diverse Natural Infection Antibodies
利用地理多样性自然感染抗体剖析人乳头瘤病毒谱系特异性衣壳抗原性
Kavita Panwar and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e145–e150, https://doi.org/10.1093/infdis/jiaf502
43
Respiratory Virus Infections and Pulmonary Impairment After Allogeneic Hematopoietic Cell Transplantation
异基因造血细胞移植后呼吸道病毒感染与肺功能损害
Guang-Shing Cheng and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e151–e163, https://doi.org/10.1093/infdis/jiaf503
Antimicrobial Resistance (AMR)（抗菌药物耐药性）
44
Insights Into Global Antimicrobial Resistance Dynamics Through the Sequencing of Enteric Bacteria From US International Travelers
通过对美国国际旅行者肠道细菌测序洞察全球抗菌药物耐药性动态
Sushmita Sridhar and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e164–e173, https://doi.org/10.1093/infdis/jiaf469
45
The Burden of Surgical Site Infections With Pathogens Presumably Resistant to Perioperative Prophylaxis in Orthopedic Tumor Surgery: Secondary Analysis of the Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) Trial
骨科肿瘤手术中疑似对围手术期预防用药耐药的手术部位感染负担：肿瘤手术预防性抗生素方案（PARITY）试验的二次分析
Sabine Kuster and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e174–e182, https://doi.org/10.1093/infdis/jiaf513
46
Foreign Combatants Wounded in Ukraine Colonized by Extensively Drug-Resistant Organisms: A Potential Source of Global Dissemination
在乌克兰受伤的外国战斗人员被广泛耐药菌定植：全球传播的潜在来源
Patrick Mc Gann and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e183–e191, https://doi.org/10.1093/infdis/jiaf538
HIV/AIDs（HIV/艾滋病）
47
Long-Acting Antiretroviral Therapy for Breastfeeding Women With HIV Experiencing Barriers to Adherence in Zimbabwe: Modeling Clinical Impact and Cost-effectiveness
针对津巴布韦存在依从性障碍的感染HIV的哺乳期妇女采用长效抗逆转录病毒疗法的临床影响和成本效益建模
Sujata E Tewari and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e192–e202, https://doi.org/10.1093/infdis/jiaf521
48
Resistance Analyses of Lenacapavir, Emtricitabine/Tenofovir Alafenamide and Emtricitabine/Tenofovir Disoproxil Fumarate in the PURPOSE 1 and 2 Studies
PURPOSE 1和2研究中来那卡帕韦、恩曲他滨/丙酚替诺福韦和恩曲他滨/富马酸替诺福韦二吡呋酯的耐药性分析
Stephanie Cox and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e203–e211, https://doi.org/10.1093/infdis/jiaf533
49
Resistance Analysis of Low-Level Virologic Rebound During HIV-1 Treatment With Lenacapavir and Broadly Neutralizing Antibodies Teropavimab and Zinlirvimab
使用来那卡帕韦和广谱中和抗体特罗帕维单抗及津利瑞单抗治疗HIV - 1期间低水平病毒学反弹的耐药性分析
Lisa Selzer and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e212–e220, https://doi.org/10.1093/infdis/jiaf559
50
IL-4 Correlates With Bone Mineral Density in Men, and IL-4 Depletion May Drive Bone Loss in Men With HIV
白细胞介素 - 4与男性骨矿物质密度相关，白细胞介素 - 4耗竭可能导致感染HIV男性骨丢失
Ighovwerha Ofotokun and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e221–e229, https://doi.org/10.1093/infdis/jiaf570
Correspondence（读者来信）
51
External Validation of Pediatric Pneumonia and Bronchiolitis Risk Scores to Predict Mortality in Children Hospitalized in Kenya: A Retrospective Cohort Study
儿科肺炎和毛细支气管炎风险评分在预测肯尼亚住院儿童死亡率方面的外部验证：一项回顾性队列研究
Becky Gordon and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e230–e238, https://doi.org/10.1093/infdis/jiaf377
52
Seroprevalence of Antibodies Against Legionella Species in Northeastern Australian Blood Donors, 2016 and 2023
2016年和2023年澳大利亚东北部献血者中针对军团菌属抗体的血清阳性率
Juniper Lethbridge and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e239–e249, https://doi.org/10.1093/infdis/jiaf407
53
Diagnostic Performance and Kinetics of Hepatitis E Viral RNA and IgM Antibody Test Positivity in a Genotype 1 Outbreak in South Sudan
南苏丹1型基因型戊型肝炎病毒暴发期间戊型肝炎病毒RNA和IgM抗体检测阳性的诊断性能和动力学
Aybüke Koyuncu and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e250–e258, https://doi.org/10.1093/infdis/jiaf436
54
Leptospirosis Prevalence and Risk Factors Among Patients Presenting With Fever to 4 Healthcare Sites in Sub-Saharan Africa and South East Asia: An International Multisite Observational and Nested Case–Control Study
撒哈拉以南非洲和东南亚4个医疗站点发热患者中钩端螺旋体病的流行率和危险因素：一项国际多站点观察性和嵌套病例对照研究
John A Crump and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e259–e270, https://doi.org/10.1093/infdis/jiaf464
55
Refined Transgenic Mouse Models Which Recapitulate the Natural Features of Chronic Wasting Disease With Rapid Prion Disease Onsets
改良转基因小鼠模型可快速引发朊病毒病并重现慢性消耗性疾病的自然特征
Joseph P DeFranco and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e271–e276, https://doi.org/10.1093/infdis/jiaf529
Correction（更正）
56
Correction to: Monocytes and Macrophages, Targets of Severe Acute Respiratory Syndrome Coronavirus 2: The Clue for Coronavirus Disease 2019 Immunoparalysis
更正：单核细胞和巨噬细胞——严重急性呼吸综合征冠状病毒2的靶点：2019冠状病毒病免疫麻痹的线索
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Page e277, https://doi.org/10.1093/infdis/jiaf622
Editor's Note（编者按）
57
Editor's Note: Bartonella quintana Bacteremia and Overproduction of Interleukin-10: Model of Bacterial Persistence in Homeless People
编者按：五日热巴尔通体菌血症和白细胞介素 - 10过度产生：无家可归者细菌持续存在的模型
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Page e278, https://doi.org/10.1093/infdis/jiaf623
58
Editor's Note: Oral Ivermectin in the Treatment of Body Lice
编者按：口服伊维菌素治疗体虱
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Page e279, https://doi.org/10.1093/infdis/jiaf627
JID 2025 Reviewer Recognition（《传染病杂志》2025年审稿人认证）
59
2025 JID Reviewer Recognition List
2025年《传染病杂志》审稿人认证名单
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e280–e286, https://doi.org/10.1093/infdis/jiag015
The Journal of Infectious Diseases. Volume 233 Issue 2
传染病杂志 233卷 2期
https://academic.oup.com/jid/issue/
Editorials（社论）
1
2025 Content Collections from the IDSA Journals
2025年美国感染病学会（IDSA）期刊内容合集
Roger Bedimo and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 221–222, https://doi.org/10.1093/infdis/jiag041
2
“Fostemsavir: More Than Meets the Eye”
“福替沙韦：不止于表面所见”
Siddharth Kogilwaimath and Netanya S Utay
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 223–226, https://doi.org/10.1093/infdis/jiaf462
3
On-Demand Dosing of HIV Preexposure Prophylaxis for Women: Has Their Time Finally Come?
女性按需服用艾滋病病毒暴露前预防药物：时机是否已到？
Susan P Buchbinder and Peter L Anderson
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 227–229, https://doi.org/10.1093/infdis/jiaf507
Invited Perspective（特邀观点）
4
The Changing Paradigm in Infectious Diseases—Host-Directed Medicine: Implications for the Next Generation of ID Physicians
感染性疾病领域的范式转变——宿主导向疗法：对下一代传染病医师的影响
Jatin M Vyas and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 230–234, https://doi.org/10.1093/infdis/jiaf497
Invited ID Translational Science Update（特邀传染病转化医学更新）
5
Targeting Tryptophan Metabolism for Tuberculosis Biomarkers and Host-Directed Therapy
以色氨酸代谢为靶点，开发结核病生物标志物和宿主导向疗法
Jeffrey M Collins and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 235–243, https://doi.org/10.1093/infdis/jiaf510
6
Clinical Commentary on: Targeting Tryptophan Metabolism for Tuberculosis Biomarkers and Host-Directed Therapy
关于“以色氨酸代谢为靶点，开发结核病生物标志物和宿主导向疗法”的临床评论
Joel D Ernst
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 244–246, https://doi.org/10.1093/infdis/jiaf624
Major Articles and Brief Reports（主要论著与简要报告）
HIV/AIDs（人类免疫缺陷病毒/艾滋病）
7
Fostemsavir Decreases the Levels of Anti-gp120 CD4-Induced Antibodies in Heavily Treatment-Experienced People With HIV
福替沙韦可降低经治重度HIV感染者体内抗gp120 CD4诱导抗体的水平
Mehdi Benlarbi and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 247–256, https://doi.org/10.1093/infdis/jiaf461
8
Optimizing On-Demand Tenofovir Disoproxil Fumarate/Emtricitabine Dosing in Women for HIV Prevention
优化女性按需服用富马酸替诺福韦二吡呋酯/恩曲他滨预防HIV感染的剂量
Nathan Engel and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 257–260, https://doi.org/10.1093/infdis/jiaf459
9
Cabotegravir and Rilpivirine Concentrations and HIV-1 RNA Suppression in Genital Fluids and Rectum in People with HIV on Long-Acting Intramuscular Cabotegravir Plus Rilpivirine Antiretroviral Therapy
接受长效肌肉注射卡博特韦加利匹韦林抗逆转录病毒治疗的HIV感染者生殖道分泌物和直肠中的卡博特韦和利匹韦林浓度及HIV-1 RNA抑制情况
Analuz Fernández and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 261–266, https://doi.org/10.1093/infdis/jiaf551
10
Elimination of Human Immunodeficiency Virus Reservoirs Harboring Intact Proviruses
清除携带完整前病毒的HIV储存库
Min Li and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 267–277, https://doi.org/10.1093/infdis/jiaf373
11
Vaccination Against Pathogens Targeting Cell-Derived Cryptic Antigens
针对细胞来源的隐蔽抗原的病原体疫苗接种
Emily S Clark and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 278–286, https://doi.org/10.1093/infdis/jiaf593
12
NAT2 Polymorphisms and Antituberculosis-Induced Hepatotoxicity in Thai People Living With HIV: Insights From a Pharmacogenetic–Pharmacokinetic Cohort Study
泰国HIV感染者NAT2基因多态性与抗结核治疗所致肝毒性的关系：一项药物基因组学-药代动力学队列研究的见解
Napon Hiranburana and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 287–297, https://doi.org/10.1093/infdis/jiaf511
Bacterial Disease Pathogenesis（细菌性疾病发病机制）
13
Interplay between Tetanus, Diphtheria, Acellular Pertussis Vaccination in Pregnancy and Infant Pneumococcal Vaccination in Shaping Infant Pneumococcal Vaccine Serotype Carriage
孕期接种破伤风、白喉、无细胞百日咳疫苗与婴儿接种肺炎球菌疫苗对婴儿肺炎球菌疫苗血清型携带的影响
Eline Van den Bosch and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 298–306, https://doi.org/10.1093/infdis/jiaf458
14
Role of Activin A–Mediated KAT8 Expression in Regulating Ferroptosis During Mycobacterium tuberculosis Infection
Activin A介导的KAT8表达在结核分枝杆菌感染中调节铁死亡的作用
Bijewar Ashish Satish and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 307–318, https://doi.org/10.1093/infdis/jiaf482
15
Phospholipid Transporter MlaFEDCB Regulates Klebsiella pneumoniae Virulence by Modulating Fimbriae Synthesis and Stress-adaptive Growth
磷脂转运蛋白MlaFEDCB通过调节菌毛合成和应激适应性生长来调控肺炎克雷伯菌的毒力
Xiaoyu Zhao and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 319–327, https://doi.org/10.1093/infdis/jiaf517
16
Novel KPC-2 Plasmid in a Clinical Salmonella Rissen Selected by Antibiotic Pressure
抗生素压力下临床沙门氏菌里森氏菌中新型KPC-2质粒的出现
María Aznar Fernández and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 328–333, https://doi.org/10.1093/infdis/jiaf536
Viral Disease Pathogenesis（病毒性疾病发病机制）
17
Respiratory Syncytial Virus Fusion Protein Epitope-Specific Antibodies and Neutralizing Activities Against Various Respiratory Syncytial Virus Strains
呼吸道合胞病毒融合蛋白表位特异性抗体对多种呼吸道合胞病毒株的中和活性
Hisao Okabe and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 334–341, https://doi.org/10.1093/infdis/jiaf375
18
Clinical and Environmental Surveillance of Poliovirus Type 2 Outbreak Using a Novel Specific Real-time Quantitative Polymerase Chain Reaction Assay, Israel, 2022–2023
2022-2023年以色列利用新型特异性实时定量聚合酶链反应检测法对2型脊髓灰质炎病毒疫情进行临床和环境监测
Itay Bar-Or and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 342–350, https://doi.org/10.1093/infdis/jiaf387
19
Robust COVID-19 Mortality Risk Assessment: Validation of a Two-Step Algorithm From the National COVID Cohort Collaborative
稳健的COVID-19死亡风险评估：国家COVID队列协作组织的两步算法验证
Bingnan Li and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 351–362, https://doi.org/10.1093/infdis/jiaf393
20
Histone Deacetylase 6 Regulates α-Tubulin to Inhibit the Stimulator of Interferon Genes/NLR Family Pyrin Domain-Containing 3-Mediated Microglial Pyroptosis Induced by Herpes Simplex Virus Type 1 Infection
组蛋白去乙酰化酶6调节α-微管蛋白，抑制1型单纯疱疹病毒感染诱导的干扰素基因刺激因子/NLR家族含吡啶结构域蛋白3介导的小胶质细胞焦亡
Qiongzhen Zeng and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 363–374, https://doi.org/10.1093/infdis/jiaf404
Parasites（寄生虫）
21
Schistosome Infection is Associated With High-Risk Human Papillomavirus Persistence, Together With Altered Cervicovaginal Microbiota
血吸虫感染与高危型人乳头瘤病毒持续感染及宫颈阴道微生物群改变相关
Crispin Mukerebe and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 375–380, https://doi.org/10.1093/infdis/jiaf447
22
The Source-Sink Dynamics of Plasmodium vivax May Undermine Malaria Elimination Efforts in the Amazon: An Epidemiological and Population Genomic Study
恶性疟原虫的源-汇动态可能破坏亚马逊地区疟疾消除工作：一项流行病学和群体基因组学研究
Nathalia Rammé M de Albuquerque and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 381–390, https://doi.org/10.1093/infdis/jiaf457
23
Seasonal Variation and Interspecies Dynamics Among Plasmodium falciparum and ovale Species in Bagamoyo, Tanzania
坦桑尼亚巴加莫约地区恶性疟原虫和卵形疟原虫的季节性变化及种间动态
Kelly Carey-Ewend and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 391–400, https://doi.org/10.1093/infdis/jiaf498
24
Genome Sequencing of Leishmania tropica in Tissues of Moroccan Patients Reveals Microfocal Transmission Underlain by (Pseudo)Clonal and Sexual Reproduction
摩洛哥患者组织中利什曼原虫热带种的基因组测序揭示了（假）克隆和有性繁殖导致的微灶性传播
Othmane Daoui and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 401–410, https://doi.org/10.1093/infdis/jiaf485
25
Trichomonas vaginalis Among Cisgender Women Taking Doxycycline Postexposure Prophylaxis
顺性别女性服用多西环素暴露后预防药物期间的阴道毛滴虫感染情况
Fredericka Albertina Sesay and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 411–415, https://doi.org/10.1093/infdis/jiaf519
26
A BEACON for Novel Disease Threats: Leveraging Artificial Intelligence for Informal Event-Based Outbreak Surveillance
应对新型疾病威胁的“灯塔”：利用人工智能进行非正式事件疫情监测
Nahid Bhadelia and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e287–e289, https://doi.org/10.1093/infdis/jiaf642
Major Articles and Brief Reports（主要论著与简要报告）
Bacterial Disease Pathogenesis（细菌性疾病发病机制）
27
Chlamydia trachomatis-specific T Cell Immunity Reflects Widespread Exposure in South African Adolescents and Young Women
沙眼衣原体特异性T细胞免疫反映南非青少年和年轻女性广泛暴露情况
Rubina Bunjun and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e290–e300, https://doi.org/10.1093/infdis/jiaf595
28
Serum IgG1 and IgG3 Antibodies to Chlamydia trachomatis Pgp3 and Hsp60 in Men of Subfertile Couples
不育夫妇男性体内针对沙眼衣原体Pgp3和Hsp60的血清IgG1和IgG3抗体
Tiina Holster and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e301–e310, https://doi.org/10.1093/infdis/jiaf535
29
Publicly Available Neisseria Gonorrhoeae Genomes Predominantly Represent In Vitro-Derived Nonpiliated Variants
公开可用的淋病奈瑟菌基因组主要代表体外衍生的非菌毛变异体
Iryna Boiko and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e311–e321, https://doi.org/10.1093/infdis/jiaf557
30
Signal Transducers and Activators of Transcription 1 (STAT1), STAT2, and T Cells Mediate Interferon-Dependent Protection Against Neurobrucellosis
信号转导和转录激活因子1（STAT1）、STAT2和T细胞介导干扰素依赖性抗神经布鲁氏菌病的保护作用
Charles R Moley and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e322–e331, https://doi.org/10.1093/infdis/jiaf565
31
[18F]Fluorodeoxyglucose Positron Emission Tomography for Diagnosis and Monitoring of Acute Staphylococcus aureus Vascular Graft Infection in a Rat Model
[18F]氟脱氧葡萄糖正电子发射断层扫描在诊断和监测大鼠急性金黄色葡萄球菌血管移植物感染中的应用
Emma Faddy and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e332–e341, https://doi.org/10.1093/infdis/jiaf594
32
Safety and Immunogenicity of a Klebsiella pneumoniae Tetravalent Bioconjugate Vaccine (Kleb4V) Administered to Healthy Adults: A First-in-Human Phase I/II Randomized and Controlled Study
健康成年人接种肺炎克雷伯菌四价生物结合疫苗（Kleb4V）的安全性和免疫原性：一项首次人体I/II期随机对照研究
C Alaimo and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e342–e351, https://doi.org/10.1093/infdis/jiaf600
COVID-2019 Disease Pathogenesis（新冠肺炎发病机制）
33
Prevalence of Symptoms Associated With Long COVID Among Adolescents in the United States, Summer 2022
2022年夏季美国青少年中与新冠长期症状相关症状的流行情况
Deja L Edwards and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e352–e362, https://doi.org/10.1093/infdis/jiaf454
34
COVID-19 Vaccine Effectiveness in Patients With Hematologic Malignancies: A Nationwide Cohort Study
血液系统恶性肿瘤患者中COVID-19疫苗的有效性：一项全国性队列研究
Quincy Hofsink and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e363–e372, https://doi.org/10.1093/infdis/jiaf523
35
Safety and Immunogenicity of a Severe Acute Respiratory Syndrome Coronavirus 2 Spike Subunit Vaccine Stabilized in the Prefusion Conformation by a Second-Generation Molecular Clamp and Evaluated in Adults Aged 18–55 Years: A Randomized, Double-Blind, Active Comparator, Phase I Trial
一种由第二代分子夹稳定在融合前构象的严重急性呼吸综合征冠状病毒2型刺突亚单位疫苗在18 - 55岁成年人中的安全性和免疫原性：一项随机、双盲、活性对照、I期试验
Keith J Chappell and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e373–e382, https://doi.org/10.1093/infdis/jiaf568
Viral Disease Pathogenesis（病毒性疾病发病机制）
36
Durability of the Mumps Antibody Response After the Third Dose of MMR Vaccine
接种第三剂麻腮风疫苗后腮腺炎抗体反应的持久性
Sun B Sowers and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e383–e391, https://doi.org/10.1093/infdis/jiaf520
37
Immune Responses to BK Virus in Renal Transplant Recipients Receiving Intravenous Immunoglobulin Treatment
接受静脉注射免疫球蛋白治疗的肾移植受者对BK病毒的免疫反应
Kevin D He and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e392–e403, https://doi.org/10.1093/infdis/jiaf525
38
Epstein-Barr Virus Antibody Response Patterns in Endemic and Nonendemic Cases of Nasopharyngeal Carcinoma
鼻咽癌流行区和非流行区病例中EB病毒抗体反应模式
Ilona Argirion and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e404–e408, https://doi.org/10.1093/infdis/jiaf526
39
Genomic Surveillance and Antigenic Characterization of Respiratory Syncytial Virus (RSV) in Spain During the 2023-2024 Season of Nirsevimab Administration
2023 - 2024年西班牙尼塞韦单抗给药季节呼吸道合胞病毒（RSV）的基因组监测和抗原特征分析
María Iglesias-Caballero and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e409–e418, https://doi.org/10.1093/infdis/jiaf530
40
Establishment of a Cynomolgus Macaque Model for Human Adenovirus Type 55–Induced Respiratory Disease
建立食蟹猴模型用于研究人类55型腺病毒引起的呼吸道疾病
Sang Hwan Seo and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e419–e429, https://doi.org/10.1093/infdis/jiaf542
41
Adenovirus 40 and 41 Antibodies Associated With Protection From Infection in a Bangladeshi Birth Cohort
孟加拉国出生队列中与预防腺病毒40型和41型感染相关的抗体
Jennifer Hendrick and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e430–e440, https://doi.org/10.1093/infdis/jiaf558
42
Natural History of Nipah Virus in Hamsters: Strain, Route, and Sex-Associated Variability Characterized Using Large Datasets to Inform Pre-Clinical Study Design
利用大型数据集研究仓鼠中尼帕病毒的自然史：不同毒株、感染途径和性别的变异性，为临床前研究设计提供依据
Katherine A Davies and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e441–e453, https://doi.org/10.1093/infdis/jiaf549
43
Estimation of Prevention-Effective CAB-LA Concentrations Among Men Who Have Sex With Men (MSM) and Transgender Women (TGW) in HPTN 083
在HPTN 083研究中估算男男性行为者（MSM）和跨性别女性（TGW）中预防有效的长效卡博特韦浓度
Brett Hanscom and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e454–e461, https://doi.org/10.1093/infdis/jiaf561
44
Assessment of Concordant Human Papillomavirus Infection With 9-Valent Vaccine Types Across Anogenital Sites in Young Men
评估年轻男性肛门生殖器部位九价疫苗类型人乳头瘤病毒的一致感染情况
Cara J Broshkevitch and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e462–e470, https://doi.org/10.1093/infdis/jiaf564
Parasites（寄生虫）
45
From Skin to Sequence: Pan-species Detection and Speciation of Leishmania
从皮肤到序列：利什曼原虫的全物种检测与鉴定
Nicholas R Duncan and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e471–e480, https://doi.org/10.1093/infdis/jiaf345
46
A Human Monoclonal Antibody Targeting α-Gal Ameliorates Experimental Cutaneous Leishmaniasis
一种靶向α-半乳糖苷的人单克隆抗体可改善实验性皮肤利什曼病
Hyeseon Cho and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e481–e490, https://doi.org/10.1093/infdis/jiaf350
47
Artemisinin Partial Resistance Mutations in Zanzibar and Tanzania Suggest Regional Spread and African Origins, 2023
2023年桑给巴尔和坦桑尼亚的青蒿素部分耐药突变提示区域传播和非洲起源
Sean V Connelly and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e491–e495, https://doi.org/10.1093/infdis/jiaf431
48
A Multivalent Peptide Vaccine Against Malaria, Targeting Plasmodium Circumsporozoite Protein and Mosquito AgTRIO
一种针对疟疾的多价肽疫苗，靶向疟原虫环子孢子蛋白和蚊子AgTRIO
Yu-Min Chuang and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e496–e500, https://doi.org/10.1093/infdis/jiaf432
49
Spontaneous Clearance of Polymerase Chain Reaction–Positive Plasmodium vivax Parasitemia in Northwestern Thailand: An Epidemiological Perspective
泰国西北部聚合酶链反应阳性的恶性疟原虫血症的自发清除：流行病学视角
Pyae Linn Aung and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e501–e509, https://doi.org/10.1093/infdis/jiaf473
50
Gene Editing of a Carcinogenic Liver Fluke Tetraspanin Impairs Parasite Surface Biogenesis and Extracellular Vesicle Uptake by Human Host Cells
对致癌性肝吸虫四跨膜蛋白进行基因编辑，可损害寄生虫表面生物合成以及人宿主细胞对细胞外囊泡的摄取
Sujittra Chaiyadet and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e510–e520, https://doi.org/10.1093/infdis/jiaf466
Antimicrobial Resistance (AMR)（抗菌药物耐药性）
51
Ampicillin/Sulbactam in Combination with Ceftazidime/Avibactam Against Metallo-β-Lactamase-Producing Carbapenem-Resistant Acinetobacter baumannii: A Genomics-Informed Mechanism-based model
氨苄西林/舒巴坦联合头孢他啶/阿维巴坦治疗产金属β-内酰胺酶的碳青霉烯耐药鲍曼不动杆菌：基于基因组学的机制模型
Bhavatharini Arun and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e521–e533, https://doi.org/10.1093/infdis/jiaf567
52
CRISPR-Cas–associated SCCmec Variants in Methicillin-resistant Staphylococcus aureus Evade Rapid Diagnostic Detection
耐甲氧西林金黄色葡萄球菌中与CRISPR-Cas相关的SCCmec变异体可逃避快速诊断检测
Magdalena Podkowik and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e534–e540, https://doi.org/10.1093/infdis/jiaf575
53
Evaluation of Phenotypic and Genotypic Susceptibility Testing Methods for Newer β-lactam/β-lactamase Inhibitor Combinations in Multidrug Resistant Pseudomonas aeruginosa
评估多药耐药铜绿假单胞菌中新型β-内酰胺/β-内酰胺酶抑制剂组合的表型和基因型敏感性检测方法
Clayton W Hall and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e541–e549, https://doi.org/10.1093/infdis/jiaf585
Fungi（真菌）
54
Adrenal Corticosteroids and Increased Intracranial Pressure in Nonimmunocompromised Patients With Cryptococcal Meningitis
非免疫抑制患者隐球菌性脑膜炎的肾上腺皮质类固醇与颅内压升高
John E Bennett and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e550–e552, https://doi.org/10.1093/infdis/jiaf490
55
Corticosteroid Therapy and Long-Term Outcomes of Post-Infectious Inflammatory Syndrome in Non-HIV Immunosuppressed Cryptococcal Meningitis: A Multicenter Case Series
非HIV免疫抑制隐球菌性脑膜炎患者感染后炎性综合征的皮质类固醇治疗和长期预后：一项多中心病例系列研究
Yuya Ito and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e553–e560, https://doi.org/10.1093/infdis/jiaf620
56
Cerebral Venous Thrombosis in Previously Healthy Patients with Cryptococcal Meningitis
既往健康患者隐球菌性脑膜炎并发脑静脉血栓形成
Seher H Anjum and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e561–e569, https://doi.org/10.1093/infdis/jiaf653
57
The Gut as a Source of Infection for Fungal Pathogens: Increased Fecal Candida albicans Precedes Onset of Candida Late-Onset Sepsis in Very Preterm Infants
肠道作为真菌病原体感染的来源：极早产儿白色念珠菌粪便含量增加早于迟发性念珠菌脓毒症发作
Rimke R de Kroon and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e570–e581, https://doi.org/10.1093/infdis/jiaf524
Correspondence（读者来信）
58
Accurate Measurement of Viral Clearance in Early-Phase Antiviral Studies in Coronavirus Disease 2019
2019冠状病毒病早期抗病毒研究中病毒清除的准确测量
Phrutsamon Wongnak and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e582–e584, https://doi.org/10.1093/infdis/jiaf442
59
Evaluating Viral Load Sampling Schemes and Swabbing Methods for Optimal Surrogacy
评估病毒载量采样方案和拭子采集方法以实现最佳替代指标
Allyson Mateja and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e585–e586, https://doi.org/10.1093/infdis/jiaf443
60
Effect of 5FU on paracoccidioidomycosis
5-氟尿嘧啶对副球孢子菌病的影响
David A Stevens
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Page e587, https://doi.org/10.1093/infdis/jiaf508
61
Response to D. Stevens Letter
对D. Stevens信件的回复
Nycolas Preite
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Page e588, https://doi.org/10.1093/infdis/jiaf509
62
Evaluating Clinical Impacts of Accessory Genome Elements: Escherichia coli Type III Secretion System 2 in Escherichia coli and Beyond!
评估附属基因组元件的临床影响：大肠杆菌III型分泌系统2在大肠杆菌及其他细菌中的作用！
Abi Manesh and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e589–e590, https://doi.org/10.1093/infdis/jiaf515
63
Alarming Prevalence of Gonococcal Ceftriaxone Resistance in Vietnam—Role of Periodic Presumptive Antimicrobials?
越南淋球菌头孢曲松耐药性的惊人流行率——定期假定使用抗菌药物的作用？
Chris Kenyon
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e591–e592, https://doi.org/10.1093/infdis/jiaf553
The Journal of Infectious Diseases. Volume 233 Issue 3
传染病杂志 233卷 3期
https://academic.oup.com/jid/issue/
Editorial（社论）
1
Mechanistic Insights Into Increased Vulnerability to Respiratory Infections in HIV-Exposed Uninfected Infants
未感染婴儿HIV暴露对呼吸道感染易感性增加的机制研究
Cheryl Cohen and Penny Moore
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 417–419, https://doi.org/10.1093/infdis/jiaf494
Viewpoint（观点）
2
Every Body Has Value: Ending Discriminatory Restrictions on Anatomical Donations
每例身体都有其价值：终止对解剖捐赠的歧视性限制
Sara Gianella and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 420–422, https://doi.org/10.1093/infdis/jiaf413
ID Translational Science Update（传染病转化医学最新进展）
3
Syphilis Transmission: Contagion of Bodies and Words
梅毒传播：身体与言语的双重传播
Maurizio Bifulco and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 423–427, https://doi.org/10.1093/infdis/jiaf576
Major Articles and Brief Reports（主要论著与简要报告）
HIV/AIDs（人类免疫缺陷病毒/艾滋病）
4
Maternal Inflammation Likely Drives Impaired Immune Responses to Respiratory Syncytial Virus in HIV-Exposed Uninfected Infants
母体炎症可能是导致HIV暴露于未感染婴儿对呼吸道合胞病毒免疫应答受损的原因
Christiana Smith and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 428–439, https://doi.org/10.1093/infdis/jiaf493
Bacterial Disease Pathogenesis（细菌性疾病发病机制）
5
Large Reductions in Invasive Pneumococcal Disease and Related Morbidities Among Children in New Zealand After Change From PCV10 to PCV13
新西兰儿童在从PCV10换用PCV13后，侵袭性肺炎球菌病及相关发病率大幅下降
Andrew Anglemyer and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 440–444, https://doi.org/10.1093/infdis/jiaf587
6
Lack of S100A8 Impairs Lung-Protective Immunity Against Streptococcus pneumoniae
缺乏S100A8会损害针对肺炎链球菌的肺部保护性免疫
Lena Ostermann and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 445–457, https://doi.org/10.1093/infdis/jiaf647
7
Microbial Dominance in Diabetic Foot Osteomyelitis Determined With Nanopore Sequencing Techniques Predicts Positive Response to Surgical Intervention
利用纳米孔测序技术确定糖尿病足骨髓炎中的微生物优势种，可预测对手术干预的积极反应
Brian M Schmidt and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 458–464, https://doi.org/10.1093/infdis/jiaf617
8
Characteristics and Antiadhesion Activity of Chicken Single-Chain Fragment Variable Antibodies Against Helicobacter pylori Adhesin A
针对幽门螺杆菌黏附素A的鸡单链抗体片段的特性及其抗黏附活性
Yanan Gong and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 465–474, https://doi.org/10.1093/infdis/jiaf550
9
Bartonella henselae Subverts Host Cell Apoptosis by Linking Intracellular NOD2 Sensing to an AREG/EGFR Autocrine Survival Loop
汉赛巴尔通体通过将细胞内NOD2感知与AREG/EGFR自分泌生存环联系起来，破坏宿主细胞凋亡
Jun He and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 475–484, https://doi.org/10.1093/infdis/jiaf566
Viral Disease Pathogenesis（病毒性疾病发病机制）
10
Influenza-associated Excess Mortality Associated With Influenza B in Hong Kong, 2014–2023
2014 - 2023年香港地区乙型流感相关的超额死亡率
Jessica Y Wong and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 485–492, https://doi.org/10.1093/infdis/jiaf414
11
Disparate Kinetics of Viable Virus Shedding in Immunocompromised Patients: SARS-CoV-2 Versus Influenza Virus—A Prospective Real-World Cohort Study
免疫功能低下患者中存活病毒脱落动力学差异：新冠病毒与流感病毒——一项前瞻性真实世界队列研究
So Yun Lim and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 493–497, https://doi.org/10.1093/infdis/jiaf479
12
Autoantibodies Against Type I Interferons are a Prominent Feature in SARS-CoV-2 Fatal Disease and Hospitalization
针对I型干扰素的自身抗体是严重急性呼吸综合征冠状病毒2型致命性和住院治疗的显著特征
Rebeca Linhares Abreu Netto and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 498–509, https://doi.org/10.1093/infdis/jiaf514
13
Genetic Landscape of a Cohort of Children With Varicella Zoster Virus Encephalitis, Cerebellitis, and Stroke
水痘带状疱疹病毒脑炎、小脑炎和中风患儿队列的遗传学特征
Franziska Winzig and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 510–520, https://doi.org/10.1093/infdis/jiaf448
14
The Diagnostic Value of Soluble Epstein-Barr Virus BZLF1 Protein in Posttransplant Lymphoproliferative Disease Among Solid Organ and Hematopoietic Cell Transplant Recipients
可溶性爱泼斯坦-巴尔病毒BZLF1蛋白在实体器官和造血细胞移植受者移植后淋巴增殖性疾病中的诊断价值
Neval Ete Wareham and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 521–527, https://doi.org/10.1093/infdis/jiaf477
15
Noninvasive Detection of Occult yet Significant Liver Pathology in Alanine Aminotransferase–Normal Chronic Hepatitis B: A Multicenter Study
丙氨酸氨基转移酶正常的慢性乙型肝炎患者中非侵入性检测隐匿却重要的肝脏病理：一项多中心研究
Xinjie Li and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 528–540, https://doi.org/10.1093/infdis/jiaf554
16
Mesenteric Ischemia and Bacterial Translocation Precipitate the Intoxication Phase of Yellow Fever
肠系膜缺血和细菌移位促使黄热病进入中毒阶段
Mateus V Thomazella and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 541–553, https://doi.org/10.1093/infdis/jiaf483
17
Essential Role of Clathrin and Lipid Rafts in pH-dependent Entry of Chandipura Virus: Independence From Caveolin Pathway
网格蛋白和脂质筏在Chandipura病毒pH依赖性进入过程中的重要作用：独立于小窝蛋白途径
Ritudhwaj Tiwari and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 554–559, https://doi.org/10.1093/infdis/jiaf446
Fungi（真菌）
18
Blood Cultures Contain Populations of Genetically Diverse Candida albicans Strains that May Differ in Echinocandin Tolerance and Fitness
血培养中含有遗传多样的白色念珠菌菌株群体，这些菌株在棘白菌素耐受性和适应性方面可能存在差异
Giuseppe Fleres and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 560–572, https://doi.org/10.1093/infdis/jiaf495
19
Interferon-gamma Production Defects Characterize Immune Responses in Patients With Chronic Pulmonary Aspergillosis
干扰素-γ产生缺陷是慢性肺曲霉病患者免疫应答的特征
Nico A F Janssen and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 573–582, https://doi.org/10.1093/infdis/jiaf596
20
Tumor Necrosis Factor Receptor–Associated Factor 1 Inhibits Macrophage Killing of Sporothrix schenckii by Enhancing Expression and Activity of Inducible Nitric Oxide Synthase
肿瘤坏死因子受体相关因子1通过增强诱导型一氧化氮合酶的表达和活性，抑制巨噬细胞对申克孢子丝菌的杀伤作用
Congcong He and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 583–593, https://doi.org/10.1093/infdis/jiaf646
Global Health（全球健康）
21
Rifampin Exposure in Pregnant and Nonpregnant Women With Tuberculosis in India
印度结核病孕妇和非孕妇的利福平暴露情况
Prakruti S Rao and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 594–597, https://doi.org/10.1093/infdis/jiaf467
22
Evaluating the Impact of Unadjusted Confounding and Study Design on Estimated Pathogen-attributable Diarrhea Incidence Among Children in the MAL-ED Cohort
评估未调整混杂因素和研究设计对MAL-ED队列中儿童病原体归因腹泻发病率估计的影响
Charlotte R Doran and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 598–606, https://doi.org/10.1093/infdis/jiaf531
23
Defining Severe Shigellosis in the Enterics for Global Health Study: A Comparison of Leading Diarrhea Severity Definitions Among Children With Shigella Diarrhea
全球肠道健康研究中对儿童严重志贺氏菌病的定义：志贺氏菌腹泻儿童中主要腹泻严重程度定义的比较
Olivia Lang Schultes and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 607–617, https://doi.org/10.1093/infdis/jiaf630
Editorial（社论）
24
Evidence for Neuroinvasive Lassa Virus Infection in Pediatric Patients: Initial Findings and Implications
儿科患者神经侵袭性拉沙病毒感染的证据：初步发现及启示
Andrew P Platt and Daniel S Chertow
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e593–e595, https://doi.org/10.1093/infdis/jiaf548
Perspectives（展望）
25
The Emerging Role of Immunothrombosis in the Control and Pathogenesis of Mycobacterium tuberculosis
免疫血栓形成在结核分枝杆菌控制和发病机制中的新兴作用
Seán Donohue and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e596–e599, https://doi.org/10.1093/infdis/jiaf415
ID Translational Science Update（传染病转化医学最新进展）
26
Whole-Exome Sequencing for the Identification of Genetic Factors Implicated in Severe Bacterial Infections: A Systematic Review
全外显子组测序用于鉴定与严重细菌感染相关的遗传因素：一项系统综述
Morgane Gélin and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e600–e610, https://doi.org/10.1093/infdis/jiag006
Major Articles and Brief Reports（主要论著与简要报告）
Viral Disease Pathogenesis（病毒性疾病发病机制）
27
Presence of Lassa Virus RNA in Cerebrospinal Fluid Indicating Neuroinvasive Lassa Fever in Pediatric Patients From Edo State, Nigeria
尼日利亚埃多州儿科患者脑脊液中存在拉沙病毒RNA，表明存在神经侵袭性拉沙热
Hannah Caroline Sophie Müller and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e611–e620, https://doi.org/10.1093/infdis/jiaf547
28
Anti-HBs Immune Complex Levels: A Novel Marker of Hepatitis Flare Following Nucleos(t)ide Analog Withdrawal in HBeAg-negative Chronic Hepatitis B
抗-HBs免疫复合物水平：乙型肝炎e抗原阴性慢性乙型肝炎患者核苷（酸）类似物停药后肝炎发作的新型标志物
S J Hume and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e621–e629, https://doi.org/10.1093/infdis/jiaf569
29
Oral Microbiome Diversity Matters on Nucleos(t)ide Analogue Cessation in Chronic Hepatitis B
慢性乙型肝炎患者核苷（酸）类似物停药时口腔微生物组多样性的重要性
Mahin Ghorbani and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e630–e640, https://doi.org/10.1093/infdis/jiaf591
30
A Phase 1 Double-Blinded Trial to Evaluate Safety, Immunogenicity, and Dosing of Measles-Vectored Chikungunya Virus Vaccine (MV-CHIK) in Healthy Adults
一项评估健康成年人接种麻疹载体基孔肯雅病毒疫苗（MV-CHIK）的安全性、免疫原性和剂量的1期双盲试验
Patricia Winokur and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e641–e645, https://doi.org/10.1093/infdis/jiaf571
31
A Test-Negative Design for Immune Correlates Approximates a Traditional Exposure-Proximal Design but Requires Far Fewer Blood Samples
免疫相关因素的检验阴性设计近似于传统的暴露近端设计，但所需血液样本数量要少得多
Dean Follmann and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e646–e650, https://doi.org/10.1093/infdis/jiaf572
32
Comparison of Healthcare Resource Utilization and Disease Outcomes in Adults Hospitalized with Human Metapneumovirus and Respiratory Syncytial Virus
人偏肺病毒和呼吸道合胞病毒感染住院成人患者的医疗资源利用情况和疾病预后比较
Emily Rayens and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e651–e661, https://doi.org/10.1093/infdis/jiaf597
33
Avian Influenza Virus A(H5N1) Genotype D1.1 Is Better Adapted to Human Nasal and Airway Organoids Than Genotype B3.13
禽流感病毒A(H5N1) D1.1基因型比B3.13基因型更适应人体鼻腔和气道类器官
Xiaojuan Zhang and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e662–e666, https://doi.org/10.1093/infdis/jiaf598
34
The Impact of Corticosteroid Therapy on Patients With West Nile Virus: A Retrospective Cohort Study
皮质类固醇治疗对西尼罗河病毒患者的影响：一项回顾性队列研究
Itamar Poran and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e667–e673, https://doi.org/10.1093/infdis/jiaf601
35
Serological Survey in African Nonhuman Primate Species in Cameroon and the Democratic Republic of the Congo Reveals Low Overall Seroprevalence to Mpox Virus
对喀麦隆和刚果民主共和国非洲非人灵长类物种的血清学调查显示，猴痘病毒总体血清阳性率较低
Neraide Biai and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e674–e686, https://doi.org/10.1093/infdis/jiaf602
Bacterial Disease Pathogenesis（细菌性疾病发病机制）
36
Manufacture of Clostridioides difficile Spores for Experimental Infection of Human Volunteers
用于人体志愿者实验性感染的艰难梭菌孢子制备
Annefleur D O Hensen and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e687–e695, https://doi.org/10.1093/infdis/jiaf612
37
Digital Anorectal Examination to Self-detect Primary Syphilis: A Prospective Cohort Study
数字肛门直肠检查用于自我检测原发性梅毒：一项前瞻性队列研究
Julien Tran and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e696–e705, https://doi.org/10.1093/infdis/jiaf628
38
Higher Promoter Methylation of the Ubiquitin-Associated and SH3 Domain Containing A (UBASH3A) Gene Is Associated With T-Lymphocyte Ontogeny and Reduced Susceptibility to Early-Onset Sepsis
泛素相关和SH3结构域含A（UBASH3A）基因启动子高甲基化与T淋巴细胞发生及早发性脓毒症易感性降低相关
Ziyi Wang and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e706–e711, https://doi.org/10.1093/infdis/jiaf636
39
Efficacies of Sequenced Monotherapies of Mycobacterium avium Lung Infection in Mouse
小鼠肺鸟分枝杆菌感染序贯单一疗法的疗效
Ruth A Howe and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e712–e720, https://doi.org/10.1093/infdis/jiaf640
40
The Landscape and Regulatory Determinants of A-to-I RNA Editing in Escherichia coli and Pseudomonas aeruginosa Isolated From Patients With Urinary Tract and Ear Infections
从尿路感染和耳部感染患者中分离出的大肠杆菌和铜绿假单胞菌中A-to-I RNA编码的格局及调控决定因素
Eyal Elias and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e721–e730, https://doi.org/10.1093/infdis/jiaf645
Parasites（寄生虫）
41
Efficacy of Praziquantel for Treatment of Plasmodium falciparum Infection in Asymptomatic Gabonese Adults: A Double-Blind Placebo-Controlled Randomized Trial
双盲安慰剂对照随机试验评估吡喹酮治疗加蓬无症状成人恶性疟原虫感染的疗效
Johannes Mischlinger and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e731–e739, https://doi.org/10.1093/infdis/jiaf544
42
Chronic Malaria Is Associated With Trauma-related Splenic Rupture Requiring Splenectomy
慢性疟疾与创伤性脾破裂相关，需行脾切除术
Putu A I Shanti and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e740–e744, https://doi.org/10.1093/infdis/jiaf629
43
Extreme Genetic Diversity and Signatures of Balancing Selection in Plasmodium vivax Blood-Stage Antigens
间日疟原虫血液阶段抗原具有极高的遗传多样性和平衡选择的特征
Alison Paolo N Bareng and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e745–e755, https://doi.org/10.1093/infdis/jiaf539
44
How Duffy Blood Group (FY) Polymorphism and Age Modulate Vivax Malaria Risk at the Community Level: A Population-based Retrospective Cohort Study in the Amazon
社区层面杜菲血型（FY）多态性和年龄如何调节间日疟风险：亚马逊地区一项基于人群的回顾性队列研究
Carlos A Prete and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e756–e765, https://doi.org/10.1093/infdis/jiaf562
45
New Viability Assays for Acanthamoeba castellanii Trophozoites and Cysts Allow Rapid Assessment of Drug Activity
卡氏棘阿米巴滋养体和包囊新的活性检测方法可快速评估药物活性
Carrie A Flynn and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e766–e776, https://doi.org/10.1093/infdis/jiaf599
Global Health（全球健康）
46
Stunting Increases Influenza Virus Shedding Duration in Preschool/School-Aged Children
发育迟缓会增加学龄前/学龄儿童流感病毒脱落持续时间
Mia Q Zhu and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e777–e781, https://doi.org/10.1093/infdis/jiaf641
47
False-positive Malaria Rapid Diagnostic Tests are Prevalent Among Children Under 5 Years of Age in Uganda
乌干达5岁以下儿童疟疾快速诊断试验假阳性率较高
Caitlin A Cassidy and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e782–e790, https://doi.org/10.1093/infdis/jiaf604
48
Comparative Analysis of Flight Volume Effects on COVID-19 and Influenza Transmission Across Variable Control Intensities, 2019–2024
2019 - 2024年不同防控强度下航班量对新冠肺炎和流感传播影响的比较分析
Yanfang Xu and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e791–e801, https://doi.org/10.1093/infdis/jiaf545
49
High Seropositivity to rK39 and Capture of Leishmania-Infected Sand Flies in Bihar and Jharkhand Emphasize the Need for Post-Elimination Surveillance of Visceral Leishmaniasis in India
比哈尔邦和贾坎德邦rK39血清阳性率高且捕获到感染利什曼原虫的白蛉，强调印度内脏利什曼病消除后需加强监测
Eva Iniguez and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e802–e811, https://doi.org/10.1093/infdis/jiaf543
Microbiome（微生物组）
50
The Gut Microbiome and Butyrate Differentiate Clostridioides difficile Colonization and Infection in Children
肠道微生物组和丁酸盐可区分儿童艰难梭菌定植和感染
Maribeth R Nicholson and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e812–e822, https://doi.org/10.1093/infdis/jiaf631
51
Gut Microbiota Predicts the Risk of Future COVID-19 Hospitalization and Mortality: Insights From the Population-Based HELIUS Study
肠道微生物群可预测未来新冠肺炎住院和死亡风险：来自基于人群的HELIUS研究的见解
Robert F J Kullberg and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e823–e827, https://doi.org/10.1093/infdis/jiaf541
52
Douching Is Associated With Dysregulated Rectal Mucosal Immunity in Sexual Minority Men
灌洗与性少数男性直肠黏膜免疫失调相关
Courtney A Broedlow and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e828–e838, https://doi.org/10.1093/infdis/jiaf577
Correspondence（读者来信）
53
Effectiveness of 13-Valent Pneumococcal Conjugate Vaccine Against Pneumonia Hospitalization Among Medicare Beneficiaries Aged ≥65 in Long-Term Care
13价肺炎球菌结合疫苗对长期护理机构中≥65岁医疗保险受益人肺炎住院的预防效果
Wenwen Zhao and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Page e839, https://doi.org/10.1093/infdis/jiaf581
54
Letter to the Editor in Response to Zhao et al
致编辑的信（回应赵等人）
Lindsay Zielinski and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e840–e841, https://doi.org/10.1093/infdis/jiaf582
55
Fishborne Trematodiases in the United States: A Blind Spot in U.S. Emerging Infectious Disease Preparedness
美国鱼源性吸虫病：美国新兴传染病防范中的盲点
Nathkapach K Rattanapitoon and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e842–e843, https://doi.org/10.1093/infdis/jiaf588
56
Comment on “A Review of Aedes aegypti Control in Peru: Approaches and Lessons Learned”
对“秘鲁伊蚊控制回顾：方法与经验教训”的评论
Carmen Thompson Perea and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e844–e845, https://doi.org/10.1093/infdis/jiaf589
57
Balancing Pharmacokinetic Targets and Lymphocyte Declines with Once-Monthly Oral Islatravir for PrEP
平衡药代动力学目标和淋巴细胞减少情况，每月一次口服艾斯拉特韦用于暴露前预防
Anxin Wen
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e846–e847, https://doi.org/10.1093/infdis/jiaf618
58
Polio-Free, Not Risk-Free: Wastewater as Early Warning
无脊髓灰质炎，但并非无风险：废水作为早期预警
Francesco Branda and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e848–e849, https://doi.org/10.1093/infdis/jiaf643
The Journal of Infectious Diseases. Volume 233 Issue Supplement_1
传染病杂志 233卷 增刊1期
https://academic.oup.com/jid/issue/233/Supplement_1
SUPPLEMENT（增刊）
Molecular Epidemiology of β-Lactam Resistance in Gram-negative Bacteria in China
中国革兰氏阴性菌β-内酰胺酶类抗生素耐药性的分子流行病学
Supplement Articles（增补论著）
1
Aztreonam-Avibactam Resistance Due to Synergistic Interplay of ampC-Related Mutations in Carbapenem-Resistant Enterobacter spp
碳青霉烯耐药肠杆菌属中因ampC相关突变的协同作用导致的氨曲南-阿维巴坦耐药
Yang Zeng and others
The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S1–S9, https://doi.org/10.1093/infdis/jiaf384
2
Molecular Mechanisms of β-Lactam Resistance and Its Contribution to Multidrug Resistance in Helicobacter pylori
幽门螺杆菌β-内酰胺酶类抗生素耐药的分子机制及其对多重耐药的影响
Jun Zhou and others
The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S10–S20, https://doi.org/10.1093/infdis/jiaf385
3
Molecular Epidemiology and Persistence of Multidrug-Resistant Acinetobacter baumannii in Zhejiang, China (2015–2020): Insights Into Resistance, Virulence, and Transmission Dynamics
2015 - 2020年中国浙江地区多重耐药鲍曼不动杆菌的分子流行病学及持久性：对耐药性、毒力和传播动态的见解
Yisha Zhang and others
The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S21–S30, https://doi.org/10.1093/infdis/jiaf425
4
Clinical Outcomes in Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae Infection: A Cohort Study
高毒力碳青霉烯耐药肺炎克雷伯菌感染的临床预后：一项队列研究
Ya Hu and others
The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S31–S37, https://doi.org/10.1093/infdis/jiaf460
5
Reduced Susceptibility to Cefepime–Taniborbactam in Carbapenem-Resistant Klebsiella pneumoniae Attributed to Penicillin-Binding Protein 3 Modifications
碳青霉烯耐药肺炎克雷伯菌中因青霉素结合蛋白3修饰导致对头孢吡肟-他尼硼巴坦敏感性降低
Baofang Zhang and others
The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S38–S46, https://doi.org/10.1093/infdis/jiaf463
6
Isolation of Lytic Bacteriophages Against Carbapenem-Resistant Klebsiella pneumoniae of Capsular Type KL64 From Water Collected at Multiple Sites Across China
从中国多个地点采集的水样中分离出针对荚膜型KL64碳青霉烯耐药肺炎克雷伯菌的溶菌性噬菌体
Juan Li and others
The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S47–S55, https://doi.org/10.1093/infdis/jiaf607
7
Clinical and Molecular Characteristics of Carbapenem-Resistant Klebsiella pneumoniae Causing Bloodstream Infection in a Chinese Teaching Hospital
中国某教学医院引起血流感染的碳青霉烯耐药肺炎克雷伯菌的临床和分子特征
Quanfeng Liao and others
The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S56–S63, https://doi.org/10.1093/infdis/jiaf613
8
OmpK35 and OmpK36 Deficiencies Driving High-level Carbapenem Resistance in ST11 Klebsiella Pneumoniae
OmpK35和OmpK36缺失导致ST11型肺炎克雷伯菌高水平碳青霉烯耐药
Jiayuan Qin and others
The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S64–S71, https://doi.org/10.1093/infdis/jiaf621
9
Carbapenem-Resistant Klebsiella pneumoniae of Sequence Type 11: A Scoping Review
序列型11的碳青霉烯耐药肺炎克雷伯菌：一项范围综述
Yongqiang Yang and others
The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S72–S80, https://doi.org/10.1093/infdis/jiaf635
10
Emergence of Carbapenem-Resistant Escherichia coli Coharboring blaCTX-M-199 and Penicillin-Binding Protein 3 Insertion Conferring Increased Aztreonam/Avibactam Resistance in South China
中国南方出现携带blaCTX-M-199且青霉素结合蛋白3插入导致氨曲南/阿维巴坦耐药性增强的碳青霉烯耐药大肠埃希菌
Jiong Wang and others
The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S81–S91, https://doi.org/10.1093/infdis/jiag025
11
Challenges and Strategies in Managing β-Lactam–Resistant Pseudomonas aeruginosa in China
中国应对β-内酰胺酶类抗生素耐药的铜绿假单胞菌所面临的挑战和策略
Yue Li and others
The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S92–S103, https://doi.org/10.1093/infdis/jiag033
12
New Delhi Metallo-β-Lactamase Carbapenem-Resistant Klebsiella pneumoniae in Neonates: A Genome-Based Surveillance Study
新生儿中新德里金属β-内酰胺酶碳青霉烯耐药肺炎克雷伯菌：一项基于基因组的监测研究
Liting Liang and others
The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S104–S112, https://doi.org/10.1093/infdis/jiag034
13
Trends of Carbapenem-Resistant Gram-negative Bacteria in China: A Surveillance Study Between 2015 and 2024
2015 - 2024年中国碳青霉烯耐药革兰氏阴性菌的趋势：一项监测研究
Yan Guo and others
The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S113–S117, https://doi.org/10.1093/infdis/jiag083
The Journal of Infectious Diseases. Volume 233 Issue 4
传染病杂志 233卷 4期
https://academic.oup.com/jid/issue/
Editorial（社论）
1
The Editors' Update: JID Continues to Evolve
社论更新：《传染病杂志》持续发展
Cornelius J (Neil) Clancy and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 619–620, https://doi.org/10.1093/infdis/jiag159
2
Protocols for Randomized Controlled Trials: Advancing Transparency in Infectious Diseases
随机对照试验方案：提高传染病研究的透明度
Jean-Jacques Parienti and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Page 621, https://doi.org/10.1093/infdis/jiag134
3
Dissecting the Impact of the Gut Microbiome on HIV Reservoir Dynamics
剖析肠道微生物组对HIV储存库动态的影响
Christopher M Basting and Nichole R Klatt
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 622–624, https://doi.org/10.1093/infdis/jiaf560
Viewpoint（观点）
4
Doxycycline Post-exposure Prophylaxis and Off-target Antimicrobial Resistance: Potential Amplification Within Sexual Networks
多西环素暴露后预防用药与非靶向抗菌药物耐药性：性网络内潜在的耐药性放大
Manon Roberts and Peter Davis
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 625–627, https://doi.org/10.1093/infdis/jiaf439
5
Clearing the Air: Rethinking Airway Infection With CFTR Modulators
清除迷雾：重新思考囊性纤维化跨膜转导调节因子调节剂治疗下的气道感染
Edith T Zemanick and Ranjani Somayaji
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 628–630, https://doi.org/10.1093/infdis/jiaf625
Invited ID Translational Science Update（特邀传染病转化医学更新）
6
Microbiota, Mucus, and Modulators: Cystic Fibrosis Infection Pathogenesis in the Cystic Fibrosis Transmembrane Conductance Regulator Modulator Era
微生物群、黏液与调节剂：囊性纤维化跨膜转导调节因子调节剂时代囊性纤维化感染的发病机制
Christina S Thornton and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 631–639, https://doi.org/10.1093/infdis/jiaf626
Major Articles and Brief Reports（论著与简报）
HIV/AIDs（人类免疫缺陷病毒/艾滋病）
7
HIV Reservoir Dynamics and Bacteriome Composition Along the Gut Axis
肠道轴上HIV储存库动态与细菌群组成
Mattia Trunfio and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 640–651, https://doi.org/10.1093/infdis/jiaf546
8
Mitochondrial DNA Fragment Dynamics in Acute and Chronic Human Immunodeficiency Virus: Insights From Human and Nonhuman Primate Models
急性和慢性人类免疫缺陷病毒感染中线粒体DNA片段动态：来自人类和非人类灵长类动物模型的见解
Jing Sun and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 652–663, https://doi.org/10.1093/infdis/jiag014
9
Multiancestry Genome-Wide Association Study Identifies Variants in a Zinc Finger Gene Cluster as Novel Regulators of HIV Control
多祖先全基因组关联研究确定锌指基因簇中的变异体作为HIV控制的新型调节因子
Abraham Awada and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 664–673, https://doi.org/10.1093/infdis/jiag072
Bacterial Disease Pathogenesis（细菌性疾病发病机制）
10
Respiratory Syncytial Virus–Mediated Gas6/Axl Axis Induces Hyporesponsive Macrophages to Promote Pneumococcal Proliferation in the Nasopharynx
呼吸道合胞病毒介导的Gas6/Axl轴诱导巨噬细胞低反应性以促进鼻咽部肺炎链球菌增殖
Saki Ishikawa and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 674–684, https://doi.org/10.1093/infdis/jiag004
11
Variable Staphylothrombin Activity in Staphylococcus aureus Bloodstream Infections
金黄色葡萄球菌血流感染中可变的葡萄球菌凝血酶活性
Gregory L Damhorst and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 685–695, https://doi.org/10.1093/infdis/jiag012
12
TLR4–MyD88–NF-κB Signaling in the Airway Epithelium Promotes Acinetobacter baumannii Clearance
气道上皮细胞中的TLR4-MyD88-NF-κB信号通路促进鲍曼不动杆菌的清除
Jisun Kim and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 696–705, https://doi.org/10.1093/infdis/jiag061
Viral Disease Pathogenesis（病毒性疾病发病机制）
13
Ganciclovir Dosing in Premature Infants Receiving Treatment for Congenital Cytomegalovirus Infection: Results of a Prospective Pharmacokinetic Study
先天性巨细胞病毒感染接受治疗的早产儿更昔洛韦剂量：一项前瞻性药代动力学研究结果
Edward P Acosta and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 706–713, https://doi.org/10.1093/infdis/jiaf528
14
National- and State-level SARS-CoV-2 Immunity Trends From January 2020 to December 2023: a Mathematical Modeling Analysis
2020年1月至2023年12月国家及州级SARS-CoV-2免疫趋势：一项数学建模分析
Fayette Klaassen and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 714–724, https://doi.org/10.1093/infdis/jiaf532
15
Risk- and Response-Adapted Treatment in Pediatric Epstein-Barr Virus–Associated Hemophagocytic Lymphohistiocytosis
儿童EB病毒相关噬血细胞性淋巴组织细胞增生症的风险和反应适应性治疗
Jing Miao and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 725–734, https://doi.org/10.1093/infdis/jiaf556
16
IPVS Consensus Statement on The Natural History of Cervical Human Papillomavirus Infection
国际乳头瘤病毒学会关于宫颈人乳头瘤病毒感染自然史的共识声明
Marc D Ryser and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 735–744, https://doi.org/10.1093/infdis/jiaf574
17
Long Non-Coding RNA NEAT1 Inhibits Enterovirus 71 Replication by Enhancing IFN-β Transcription Through DDX60 Signaling: Pathological Insights and Clinical Implications
长链非编码RNA NEAT1通过DDX60信号增强IFN-β转录抑制肠道病毒71型复制：病理学见解与临床意义
Dong Li and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 745–757, https://doi.org/10.1093/infdis/jiaf578
18
A Threshold in Anti–EBNA-1 Antibody Titers Distinguishes Salivary EBV Shedders From Nonshedders
抗EBNA-1抗体滴度的阈值可区分唾液EB病毒脱落者与非脱落者
João Vitor Mahler and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 758–762, https://doi.org/10.1093/infdis/jiag010
Tuberculosis（结核病）
19
Tuberculosis Disease Prevalence Among People Who Smoke Illicit Drugs: A Respondent- Driven Sampling Study in the Western Cape, South Africa
南非西开普省使用受访者驱动抽样法研究吸食非法毒品者中结核病的患病率
Samantha Malatesta and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 763–772, https://doi.org/10.1093/infdis/jiaf481
20
Childhood Tuberculosis and Risk of Frailty in Later Life: Evidence From a Nationally Representative Study in Brazil
巴西一项全国代表性研究显示儿童期结核病与晚年衰弱风险的关系
Evelyn Lepka de Lima and Márlon Juliano Romero Aliberti
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 773–776, https://doi.org/10.1093/infdis/jiaf563
21
A Monovalent SMAC Mimetic as a Potential Host-Directed Therapy for Tuberculosis
单价SMAC模拟物作为结核病潜在宿主导向疗法
Jiahong Ji and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 777–786, https://doi.org/10.1093/infdis/jiag031
22
Cerebrospinal Fluid Hypo-inflammation Drives Mortality in HIV-Associated Tuberculous Meningitis
脑脊液低炎症反应是HIV相关结核性脑膜炎死亡的原因
Anna L Wilt and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 787–798, https://doi.org/10.1093/infdis/jiag032
Editorial（社论）
23
Guiding Lines: Practical and Accessible Approaches for Analyzing Serological Data for Infectious Disease Surveillance
指导方针：用于传染病监测的血清学数据分析的实用且易获取的方法
Laura C Steinhardt
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e850–e852, https://doi.org/10.1093/infdis/jiag054
Perspectives（观点）
24
Commensal Bacteria: An Under-recognized Cause of Pneumonia
共生菌：一种被忽视的肺炎病因
Daniel M Musher and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e853–e856, https://doi.org/10.1093/infdis/jiag053
25
The Role of Antiviral Treatment of Influenza in Reducing Hospitalizations and Other Severe Outcomes: A Need for More Evidence
抗病毒治疗流感在减少住院和其他严重结局方面的作用：需要更多证据
Mark W Tenforde and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e857–e861, https://doi.org/10.1093/infdis/jiaf573
Major Articles and Brief Reports（论著与简报）
Special Report（专题报告）
26
Whose Line Is it Anyway? Defining Seropositivity Cutoffs for Infectious Disease Surveillance
究竟以谁为准？确定传染病监测血清阳性临界值
Michael T White and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e862–e871, https://doi.org/10.1093/infdis/jiaf537
Parasites（寄生虫）
27
Quantifying the Role of Importation on Sustained Malaria Transmission in a Low-to-Moderate Burden Region of Southwest Uganda
量化输入在维持乌干达西南部低至中度负担地区疟疾持续传播中的作用
Adrienne Epstein and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e872–e881, https://doi.org/10.1093/infdis/jiag008
28
Antibody-Dependent Neutrophil Phagocytosis of Plasmodium falciparum–Infected Erythrocytes Is Mediated by FcγRIIa
抗体依赖的中性粒细胞吞噬恶性疟原虫感染的红细胞由FcγRIIa介导
Maria Saeed and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e882–e890, https://doi.org/10.1093/infdis/jiag071
29
Comparison of CD4 T-Cell Response in Plasmodium falciparum and vivax Malaria
恶性疟原虫和间日疟原虫疟疾中CD4 T细胞反应的比较
Mayimuna Nalubega and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e891–e901, https://doi.org/10.1093/infdis/jiag115
HIV/AIDs（人类免疫缺陷病毒/艾滋病）
30
Persistent Increased Plasmacytoid Dendritic Cells and Inflammation in People With HIV Years After Tuberculosis
结核病治愈数年后，HIV感染者体内浆细胞样树突状细胞持续增多且炎症反应持续存在
Maureen Ward and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e902–e912, https://doi.org/10.1093/infdis/jiaf499
31
Neuroaxonal Injury in Acute HIV Infection and Following Immediate Antiretroviral Therapy
急性HIV感染期及立即接受抗逆转录病毒治疗后出现的神经轴突损伤
Phillip Chan and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e913–e922, https://doi.org/10.1093/infdis/jiaf583
32
Weekly Oral Prophylaxis With MK-8527 Protects Rhesus Macaques From Intrarectal Challenge With Simian–Human Immunodeficiency Virus
每周口服MK-8527进行预防可保护恒河猴免受猴-人免疫缺陷病毒的直肠攻击
Tracy L Diamond and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e923–e931, https://doi.org/10.1093/infdis/jiaf610
33
Partial Post-exposure Protection by Topical Inserts Containing Tenofovir Alafenamide Fumarate/Elvitegravir in a Macaque Model of Rectal Simian HIV (SHIV) Infection
在猕猴直肠猴免疫缺陷病毒（SHIV）感染模型中，含富马酸替诺福韦艾拉酚胺/埃维替韦的局部插入物提供部分暴露后保护
Natalia Makarova and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e932–e936, https://doi.org/10.1093/infdis/jiaf611
34
Human Immunodeficiency Virus–Associated Proteomic Signature of Myocardial Fibrosis and Incident Heart Failure
人类免疫缺陷病毒相关心肌纤维化和偶发心力衰竭的蛋白质组学特征
Tess E Peterson and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e937–e947, https://doi.org/10.1093/infdis/jiag013
Bacterial Disease Pathogenesis（细菌性疾病发病机制）
35
Treatment of Pseudomonas by Removal of Cloaking Antibodies: Is Common Polysaccharide Antigen a Factor?
通过去除伪装抗体治疗铜绿假单胞菌感染：常见多糖抗原是否是一个因素？
Joshua N Monteith and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e948–e956, https://doi.org/10.1093/infdis/jiag002
36
High Prevalence and Genotypic Diversity of Persistent Chlamydia Trachomatis Infections Among South African Adolescent Girls and Young Women: A Tale of Two Cities
南非少女和年轻女性中持续性沙眼衣原体感染的患病率高且基因型多样：两个城市的对比情况
Smritee Dabee and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e957–e962, https://doi.org/10.1093/infdis/jiag023
37
The Effect of Pertussis Vaccination During Pregnancy on the Binding Epitopes and Avidity of Anti–Pertussis Toxin Immunoglobulin G Antibodies in Infants and Their Mothers
孕期接种百日咳疫苗对婴儿及其母亲体内抗百日咳毒素免疫球蛋白G抗体的结合表位和亲和力的影响
Aapo Knuutila and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e963–e972, https://doi.org/10.1093/infdis/jiag048
Tuberculosis（结核病）
38
Accuracy of the Phenotypic 1G Test to Detect Mycobacterium tuberculosis and Drug Resistance From Sputa in the US-Mexico Border
表型1G试验检测美国-墨西哥边境痰液中结核分枝杆菌及耐药性的准确性
Mia Aguirre and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e973–e980, https://doi.org/10.1093/infdis/jiaf638
39
Mycobacterium tuberculosis–Specific CFP-10/ESAT-6 CD4 and CD8 T-Cell Non-IFN-γ+ Responses Are Common in Young Kenyan Children Despite Low Reported Tuberculosis Exposure
尽管报告的结核病暴露率较低，但肯尼亚幼儿中仍普遍存在结核分枝杆菌特异性CFP-10/ESAT-6 CD4和CD8 T细胞非γ干扰素阳性反应
Sylvia M LaCourse and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e981–e989, https://doi.org/10.1093/infdis/jiag039
40
Modeling the Impact of Case Finding for Tuberculosis: The Role of Infection Dynamics
结核病病例发现的影响建模：感染动态的作用
Theresa S Ryckman and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e990–e998, https://doi.org/10.1093/infdis/jiag050
41
Population Pharmacokinetic Modeling of Standard- and High-Dose Rifampicin for Tuberculosis Preventive Therapy in the 2R2 Randomized Controlled Trial
2R2随机对照试验中用于结核病预防治疗的标准剂量和高剂量利福平的群体药代动力学建模
Fajri Gafar and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e999–e1010, https://doi.org/10.1093/infdis/jiag052
Viruses（病毒）
42
Improved Immune Response Against Influenza A Viruses With Receipt of a Recombinant Influenza Vaccine in Healthcare Personnel With Prior Low Antibody Response to Egg-Based Influenza Vaccines, Israel, 2019–2020
2019-2020年，以色列既往对基于鸡蛋的流感疫苗抗体反应低的医护人员接种重组流感疫苗后，对甲型流感病毒的免疫反应有所改善
Kelsey M Sumner and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1011–e1021, https://doi.org/10.1093/infdis/jiaf605
43
Antineuraminidase Antibody Responses in Older Adults After Consecutive Vaccinations With Enhanced Influenza Vaccines: A Randomized Controlled Trial
老年人连续接种强化流感疫苗后抗神经氨酸酶抗体反应：一项随机对照试验
Pavithra Daulagala and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1022–e1030, https://doi.org/10.1093/infdis/jiaf616
44
The Pandemic Respiratory Virus Epidemiological Surveillance Trial-A Self-swab Surveillance System for Respiratory Viruses Nested Within FluTracking
大流行性呼吸道病毒流行病学监测试验——嵌入FluTracking的呼吸道病毒自我拭子监测系统
Camille Esneau and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1031–e1039, https://doi.org/10.1093/infdis/jiaf632
45
Intracellular Ganciclovir Triphosphate Concentrations in Children With Congenital Cytomegalovirus Infection
先天性巨细胞病毒感染患儿体内更昔洛韦三磷酸的细胞内浓度
Brent Lindquist-Kleissler and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1040–e1045, https://doi.org/10.1093/infdis/jiaf633
46
Hepatitis E Virus Infection in Patients With Chronic Liver Diseases: A Latin American Multicenter Study
拉丁美洲多中心研究：慢性肝病患者中的戊型肝炎病毒感染情况
Anabella Clara Fantilli and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1046–e1055, https://doi.org/10.1093/infdis/jiaf615
47
In Vivo Risk Assessment of Yellow Fever Virus Transmission Through Breastfeeding, and Mechanistic Insights
母乳喂养传播黄热病病毒的体内风险评估及机制研究
Jeanne Pascard and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1056–e1068, https://doi.org/10.1093/infdis/jiaf637
Letters to the Editor（致编辑的信）
48
Re: Estimating the Early Transmission Inhibition of New Treatment Regimens for Drug-Resistant Tuberculosis
回复：估算耐药结核病新治疗方案对早期传播的抑制作用
Tom A Yates and David A Barr
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1069–e1070, https://doi.org/10.1093/infdis/jiaf655
49
Reply to Yates and Barr
回复耶茨和巴尔
Ruvandhi R Nathavitharana and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1071–e1072, https://doi.org/10.1093/infdis/jiaf656
50
How “Enhanced” Are Enhanced Influenza Vaccines for Neuraminidase? Antigen Content and Baseline Immunity Revisited
强化流感疫苗对神经氨酸酶的“强化”程度如何？重新审视抗原含量和基线免疫力
Xiaowei Zhang
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1073–e1074, https://doi.org/10.1093/infdis/jiag042
51
Response to Letter to the Editor Regarding the Immunogenicity of Enhanced Influenza Vaccines in Inducing Neuraminidase Inhibition Antibodies
回复致编辑的关于“强化流感疫苗诱导神经氨酸酶抑制抗体免疫原性”的信
Pavithra Daulagala and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1075–e1076, https://doi.org/10.1093/infdis/jiag043
52
Comment on B-Cell Subset Representation Predicts SARS-CoV-2 Vaccine Response in Solid Organ Transplant Recipients
关于“B细胞亚群表征预测实体器官移植受者对SARS-CoV-2疫苗反应”的评论
Pınar Belviranlı Keskin
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Page e1077, https://doi.org/10.1093/infdis/jiag055
53
Response to Dr Belviranli Keskin's Comments
回复贝尔维兰利·凯斯金的评论
James J Knox and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Page e1078, https://doi.org/10.1093/infdis/jiag056
54
Beyond Antibodies: Influenza Vaccine Induced T-Cell Response in Hematological Malignancy— Commentary on Insights From Hall et al
超越抗体：流感疫苗在血液系统恶性肿瘤患者中诱导的T细胞反应——对霍尔等人见解的评论
Katja M Sauer and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1079–e1080, https://doi.org/10.1093/infdis/jiag079
55
Advancing Understanding of Viral Interference: Insights From Rhinovirus–SARS-CoV-2 Cross-protection and Immunologic Perspectives
加深对病毒干扰的理解：来自鼻病毒-SARS-CoV-2交叉保护和免疫学视角的见解
Weikai Dong and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1081–e1082, https://doi.org/10.1093/infdis/jiag080
56
When PD-1 Meets Plaque: Making CD8 Senescence Signals Clinically Actionable in Treated HIV
当PD-1遇上斑块：使治疗后的HIV感染者中CD8细胞衰老信号具有临床可操作性
Xiaowei Zhang
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1083–e1084, https://doi.org/10.1093/infdis/jiag081
The Journal of Infectious Diseases. Volume 233 Issue 5
传染病杂志 233卷 5期
https://academic.oup.com/jid/issue/
Editorial（社论）
1
Beyond Transplantation: Cytomegalovirus Viremia as a Therapeutic Target in Non-Cytomegalovirus Syndromes
超越移植：巨细胞病毒血症作为非巨细胞病毒综合征的治疗靶点
Ghady Haidar
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 799–801, https://doi.org/10.1093/infdis/jiaf648
2
When Time Is of the Essence: Hepatitis C Virus RNA Point-of-Care Testing in 15Minutes Becomes a Reality
当时间至关重要：15分钟内完成丙型肝炎病毒RNA即时检测成为现实
Tanya L Applegate and Jason Grebely
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 802–805, https://doi.org/10.1093/infdis/jiaf652
Trainee’s Corner（实习生专栏）
3
The Day I Was Told I Wasn’t Doing Science—And Why I’m Grateful for It
被告知我没有在做科学的那一天——以及我为何对此心怀感激
Sara Gianella
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 806–808, https://doi.org/10.1093/infdis/jiaf614
JID Viewpoint（《传染病杂志》观点）
4
Restoring TB-specific Immunity in Early HIV Infection—the Dual Promise of Early Antiretroviral and TB Preventive Treatment
在HIV感染早期恢复结核特异性免疫——早期抗逆转录病毒治疗与结核预防性治疗的双重前景
Patrick K Moonan and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 809–811, https://doi.org/10.1093/infdis/jiaf518
Major Articles and Brief Reports（主要论著与简报）
Viral Disease Pathogenesis（病毒性疾病发病机制）
5
Cytomegalovirus DNAemia in Hospitalized Adults With SARS-CoV-2 Infection Requiring Supplemental Oxygen: Virologic and Clinical Characteristics and Association With Outcomes
需要补充氧疗的住院成人SARS-CoV-2感染患者中的巨细胞病毒DNA血症：病毒学与临床特征及其与预后的关系
Michael Boeckh and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 812–822, https://doi.org/10.1093/infdis/jiaf649
6
Development of a Rapid Automated Point-of-Care Test for Hepatitis C Viral RNA on the DASH Rapid Polymerase Chain Reaction System
基于DASH快速聚合酶链反应系统的丙型肝炎病毒RNA快速自动化即时检测的开发
Jennifer L Reed and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 823–830, https://doi.org/10.1093/infdis/jiaf608
7
Serum Markers of Fibroinflammatory Activity PRO-C3 and CPa9-HNE Are Associated with Liver-Related Outcomes in Patients with Chronic Hepatitis C
纤维炎症活动血清标志物PRO-C3和CPa9-HNE与慢性丙型肝炎患者肝脏相关预后有关
Emilie Toft Skovgaard and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 831–839, https://doi.org/10.1093/infdis/jiaf552
8
A Rapid Assay for Hepatitis C Virus RNA Detection Using Reverse-Transcription Loop-Mediated Isothermal Amplification–Coupled CRISPR-Cas12b–Based Strategy
基于逆转录环介导等温扩增联合CRISPR-Cas12b策略的丙型肝炎病毒RNA快速检测方法
Avisha Chowdhury and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 840–847, https://doi.org/10.1093/infdis/jiaf609
9
Maternal-Fetal Letermovir Exposure In Vivo and Physiologically Based Pharmacokinetic Modeling: A Rationale for Congenital Cytomegalovirus Therapy
体内母胎来特莫韦暴露及生理药代动力学建模：先天性巨细胞病毒治疗的理论基础
Valentine Faure Bardon and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 848–857, https://doi.org/10.1093/infdis/jiaf619
10
Feasibility and Safety of Aerosolized Influenza Virus Challenge in Humans Using Two Modern Delivery Systems
使用两种现代递送系统进行雾化流感病毒人体激发的可行性与安全性
Nadine Rouphael and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 858–867, https://doi.org/10.1093/infdis/jiaf603
11
Rhinovirus-Associated Lower Respiratory Tract Infection in Hospitalized Adult Patients: A Retrospective Cohort Study
住院成人患者中与鼻病毒相关的下呼吸道感染：一项回顾性队列研究
Rongling Zhang and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 868–876, https://doi.org/10.1093/infdis/jiaf651
Bacterial Disease Pathogenesis（细菌性疾病发病机制）
12
Decoding Hypervirulence in Carbapenem-Resistant Klebsiella pneumoniae: Genomic and Phenotypic Profiling Reveals Capsular Polysaccharide as a Key Driver of Pathogenicity
解码碳青霉烯耐药肺炎克雷伯菌的高毒力：基因组与表型分析揭示荚膜多糖是致病性的关键驱动因素
Li Xu and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 877–887, https://doi.org/10.1093/infdis/jiag075
13
Inflammatory Cytokine Profile in Pregnant Women Colonized With Group B Streptococcus Reveals IL-17a as a Potential Biomarker to Identify at-risk Newborns
B族链球菌定植孕妇的炎症细胞因子谱显示IL-17a可作为识别高危新生儿的潜在生物标志物
Narjis Amar and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 888–898, https://doi.org/10.1093/infdis/jiag092
14
Epitope-Based Multimeric Subunit Vaccine (ATOMSSUISpenta) Confers Broad Protection Against Streptococcus suis Infection
表位基多聚体亚单位疫苗（ATOMSSUISpenta）对猪链球菌感染提供广泛保护
Sun-Young Kim and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 899–911, https://doi.org/10.1093/infdis/jiag131
Parasites（寄生虫）
15
Pfs230 Domains 7–10 Encoded by DNA Vaccines Induce Potent Complement-Independent Transmission-Blocking Antibody Against Plasmodium falciparum
DNA疫苗编码的Pfs230结构域7–10可诱导强效非补体依赖性抗恶性疟原虫传播阻断抗体
Yi Cao and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 912–923, https://doi.org/10.1093/infdis/jiaf555
16
Uneven Plasmodium falciparum Transmission and Cryptic ovale Transmission From the Asymptomatic Reservoir in Bagamoyo, Tanzania
坦桑尼亚巴加莫约无症状感染库中恶性疟原虫传播不均与隐匿性卵形疟原虫传播
Jessica T Lin and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 924–933, https://doi.org/10.1093/infdis/jiaf634
17
Mzb1 Promotes Progression of Schistosomiasis by Inducing Endoplasmic Reticulum Stress
Mzb1通过诱导内质网应激促进血吸虫病进展
Lanyue Pan and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 934–945, https://doi.org/10.1093/infdis/jiaf639
Antimicrobial Resistance (AMR)（抗生素耐药）
18
Longitudinal Trends in Pediatric Non-Salmonella Gram-Negative Enterobacterales Infections at a Tertiary Care Center in West Africa, 2005–2023
西非一家三级医疗中心2005–2023年儿童非沙门氏菌革兰阴性肠杆菌科感染的纵向趋势
Sumanth Cherukumilli and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 946–956, https://doi.org/10.1093/infdis/jiag027
19
The Effect of a 5-Day Course of Azithromycin on Streptococcus Pneumoniae Carriage and Antimicrobial Resistance Among Kenyan Children Discharged From Hospital
阿奇霉素5天疗程对出院肯尼亚儿童肺炎链球菌携带率及抗菌药物耐药性的影响
Tanya E Libby and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 957–965, https://doi.org/10.1093/infdis/jiag028
20
Comparative Analysis of High-Dose Dual Therapies in First-Line Helicobacter pylori Eradication: An Inverse Probability of Treatment-Weighted Multicenter Study
高剂量双联方案一线幽门螺杆菌根除治疗的比较分析：一项逆概率加权多中心研究
Qingzhou Kong and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 966–974, https://doi.org/10.1093/infdis/jiag059
Editorial（社论）
21
Implementation Does Not Occur in a Vacuum: Sustaining a Comprehensive and Global Vision for HIV Research
实施并非在真空中发生：维持全面且全球化的HIV研究愿景
Sara Gianella and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1085–e1087, https://doi.org/10.1093/infdis/jiag063
22
Uncovering the Hidden Impacts of Modern Medicine's Expanding Pharmacopeia on Clostridioides difficile Infection Risk
揭示现代医学不断扩展的药物谱对艰难梭菌感染风险的隐性影响
Alison Laufer Halpin and L Clifford McDonald
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1088–e1091, https://doi.org/10.1093/infdis/jiag011
Perspectives（观点）
23
Future Directions for NIH HIV Research: A Look Ahead to 2026
美国国立卫生研究院HIV研究的未来方向：展望2026年
Geri R Donenberg and Robert W Eisinger
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1092–e1093, https://doi.org/10.1093/infdis/jiag062
ID Translational Science Update（传染病转化医学更新）
24
Immune Responses to Phage Therapy in Humans: A Review
人体对噬菌体疗法的免疫应答：综述
Kiran Bosco and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1094–e1103, https://doi.org/10.1093/infdis/jiag096
Major Articles and Brief Reports（主要论著与简报）
Bacterial Disease Pathogenesis（细菌性疾病发病机制）
25
Antibiotic and Nonantibiotic Drugs Associated With Clostridioides difficile Infection Risk: a Pharmacopoeia-Wide Case-Cohort Study
与艰难梭菌感染风险相关的抗菌及非抗菌药物：一项全药物谱病例-队列研究
Kevin A Brown and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1104–e1114, https://doi.org/10.1093/infdis/jiag001
26
Age-Specific Concentrations and Seroprevalence of Antibodies Against Salmonella Enteritidis (O:9) and Salmonella Typhimurium (O:4,5) Across 3 Sites in Kenya
肯尼亚3个地区针对鼠伤寒沙门氏菌（O:9）和伤寒沙门氏菌（O:4,5）抗体的年龄特异性浓度与血清流行率
Esther M Muthumbi and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1115–e1123, https://doi.org/10.1093/infdis/jiag114
27
Influence of Chlamydia trachomatis Sequence Variation on pgp3 Antigenicity
沙眼衣原体序列变异对pgp3抗原性的影响
Filomeno Coelho da Silva and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1124–e1129, https://doi.org/10.1093/infdis/jiag067
28
Increased Diversity and Introduction of Multidrug-Resistant Strains of Neisseria gonorrhoeae Following Cessation of COVID-19 Pandemic–Related Travel Restrictions: An Observational Genomic Epidemiologic Study
新冠疫情相关旅行限制解除后淋病奈瑟菌多样性增加及多重耐药菌株的引入：一项观察性基因组流行病学研究
Rosa C Coldbeck-Shackley and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1130–e1140, https://doi.org/10.1093/infdis/jiag097
29
Disease-Attenuated Pneumococcal Biosynthesis Gene Mutants Invade the Mucosal Epithelium and Induce Innate Immunity
致病性减弱的肺炎链球菌生物合成基因突变体可侵入黏膜上皮并诱导先天免疫
Caroline M Weight and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1141–e1153, https://doi.org/10.1093/infdis/jiag124
HIV/AIDs（人类免疫缺陷病毒/艾滋病）
30
Functional and Transcriptional Senescence Profiles of CD8+ T Cells Associate With the Presence of Carotid Plaques in People Living With HIV
HIV感染者中CD8+ T细胞的功能及转录衰老特征与颈动脉斑块有关
Marc J T Blaauw and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1154–e1164, https://doi.org/10.1093/infdis/jiag018
31
Estimating HIV-1 Viremic Time From Reservoir Sequence Diversity With Uncertainty Quantification
利用库序列多样性估算HIV-1病毒血症时间及不确定性量化
Edward N Kankaka and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1165–e1172, https://doi.org/10.1093/infdis/jiag020
32
Longitudinal Changes in Cognition and Brain Imaging in Persons With Human Immunodeficiency Virus
人类免疫缺陷病毒感染者认知功能与脑影像学的纵向变化
James Kennedy and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1173–e1180, https://doi.org/10.1093/infdis/jiag029
Antimicrobial Resistance (AMR)（抗生素耐药）
33
Epidemiological and Molecular Surveillance of Multiresistant Citrobacter freundii Complex in a Tertiary Care Hospital: A Retrospective Cohort Study
三级医疗机构中多重耐药弗氏柠檬酸杆菌复合群的流行病学与分子监测：一项回顾性队列研究
Pérince Fonton and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1181–e1192, https://doi.org/10.1093/infdis/jiag066
34
The Influence of National Antibiotic Consumption on Neisseria Gonorrhoeae Antibiotic Resistance in Norway, 2003–2024
2003–2024年挪威全国抗生素消耗对淋病奈瑟菌耐药性的影响
Patricia Campbell
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1193–e1202, https://doi.org/10.1093/infdis/jiag076
35
Restoration of Mucosa-Associated Invariant T-Cell Function in Healthcare-Associated Bacterial Infections Supports Recovery of Carbapenem Efficacy Against Resistant Bacteria Ex Vivo
医疗相关细菌感染中黏膜相关恒定T细胞功能的恢复支持碳青霉烯类药物对耐药菌疗效的体外恢复
Yiting Xue and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1203–e1214, https://doi.org/10.1093/infdis/jiag151
Parasites（寄生虫）
36
Febrile Temperature Augments Ring-stage Plasmodium falciparum Adhesion to Brain Endothelial Cells
发热温度增强环期恶性疟原虫对脑内皮细胞的黏附
Fatou Joof and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1215–e1225, https://doi.org/10.1093/infdis/jiaf474
37
Safety, Tolerability, and Pharmacokinetics of 6-Diazo-5-Oxo-L-Norleucine in Malawian Adults With and Without Malaria: A Phase 1 Dose-Escalation Clinical Trial
6-重氮-5-氧代-L-正亮氨酸在马拉维有无疟疾成年人群中的安全性、耐受性与药代动力学：一项1期剂量递增临床试验
Brittany A Riggle and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1226–e1237, https://doi.org/10.1093/infdis/jiag121
38
Tracking Plasmodium knowlesi Through Fecal DNA for Monitoring Zoonotic Transmission in Wild Macaques Across Southeast and South Asia
通过粪便DNA追踪诺氏疟原虫以监测东南亚和南亚野生猕猴中的人畜共患传播
Dhammika Leshan Wannigama and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1238–e1243, https://doi.org/10.1093/infdis/jiag128
Viruses（病毒）
39
Effectiveness of Measles-Mumps-Rubella Vaccination Among Persons Residing in a Congregate Migrant Shelter During a Measles Outbreak: An Observational Cohort Study
麻疹爆发期间聚集性移民收容所居住者麻疹-腮腺炎-风疹疫苗的有效性：一项观察性队列研究
Chelsea S Lutz and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1244–e1252, https://doi.org/10.1093/infdis/jiaf650
40
Quantifying the Impact of Switching From Rotarix to Rotavac Rotavirus Vaccine in Ghana
量化加纳从Rotarix转换为Rotavac轮状病毒疫苗的影响
Ernest O Asare and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1253–e1260, https://doi.org/10.1093/infdis/jiag003
41
Persistent T Cell Immunity Following Nipah Virus Infection: Evidence From Malaysian Survivors
尼帕病毒感染后T细胞免疫的持续存在：来自马来西亚幸存者的证据
Puteri Ainaa S Ibrahim and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1261–e1266, https://doi.org/10.1093/infdis/jiag017
42
Characterization of Mouse-Adapted Marburg and Ravn Viruses in Inbred BALB/c and Outbred CD-1 Mice
BALB/c近交系与CD-1远交系小鼠中适应小鼠的马尔堡病毒与拉文病毒的特征研究
Katherine A Davies and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1267–e1272, https://doi.org/10.1093/infdis/jiag019
43
Cross-reactive H5N1 Neuraminidase Antibodies by Age and Influenza A Imprinting Cohorts of the Past Century: Population-Based Serosurvey, British Columbia, Canada
过去一个世纪不同年龄与甲型流感印记队列中H5N1神经氨酸酶交叉反应抗体：加拿大不列颠哥伦比亚省人群血清学调查
Danuta M Skowronski and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1273–e1284, https://doi.org/10.1093/infdis/jiag030
44
Inflammasome Activation and Oxidative Stress in SARS-CoV-2 Infection and Symptomatic Rebound
SARS-CoV-2感染及症状反弹中的炎症小体激活与氧化应激
Silvia Lucena Lage and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1285–e1297, https://doi.org/10.1093/infdis/jiag037
Letters to the Editor（致编辑的信）
45
Reply to Gianella: Redefining Science Together
致Gianella的回复：共同重新定义科学
Rachel A Bender Ignacio
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1298–e1299, https://doi.org/10.1093/infdis/jiaf644
46
Response to the Day I Was Told I Wasn’t Doing Science—And Why I’m Grateful for It
对《被告知我没有在做科学的那一天——以及我为何对此心怀感激》的回应
Darcy Wooten
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Page e1300, https://doi.org/10.1093/infdis/jiag084
47
Reply to Gianella: Women in Academic Medicine Will Lead a Sea Change
致Gianella的回复：女性学者将引领学术医学的海变
Maile A Y Karris
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Page e1301, https://doi.org/10.1093/infdis/jiag109
48
Between Two Standards: Reflections on the Double Bind From a Female Chinese Infectious Disease Physician
两种标准之间：一位中国女性传染病医生对双重束缚的反思
Nan Xu
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1302–e1303, https://doi.org/10.1093/infdis/jiag101
49
When “Logistics”Becomes Science: A Research Coordinator's Response on Team-Based Discovery
当"后勤"变成科学：一位研究协调员关于团队协作发现的回应
Cheryl Dullano
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Page e1304, https://doi.org/10.1093/infdis/jiag102
50
Pushing the Stone Uphill Together
共同推石上山
Scott L Letendre
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1305–e1306, https://doi.org/10.1093/infdis/jiag125
The Journal of Infectious Diseases. Volume 233 Issue 6
传染病杂志 233卷 6期
https://academic.oup.com/jid/issue/
Editorial（社论）
1
Increasing Handgrip Strength to Combat Frailty in Human Immunodeficiency Virus: Linking Immune Exhaustion to a Bone Health Indicator
提高握力以对抗人类免疫缺陷病毒患者的衰弱：将免疫耗竭与骨健康指标相联系
Jean-Pierre Routy and Stephane Isnard
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 975–976, https://doi.org/10.1093/infdis/jiag082
2
Immune Checkpoint Inhibition Therapy Beyond the Tumor: Implications for Hepatitis B Virus in Hepatocellular Carcinoma
免疫检查点抑制疗法在肿瘤之外的应用：对肝细胞癌中乙型肝炎病毒的启示
Renato Bobadilla and Arthur Y Kim
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 977–980, https://doi.org/10.1093/infdis/jiag058
Perspective（观点）
3
The Recurring Issue of Syphilis in Europe: Comment on “Ancient Genomes Reveal a Deep History of Treponema pallidum in the Americas”
欧洲梅毒的反复问题——评《古代基因组揭示美洲苍白密螺旋体的深层历史》
M Dehmane and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 981–982, https://doi.org/10.1093/infdis/jiag022
ID Translational Science Update（传染病转化医学最新动态）
4
Evidence-Based Assessment of the Role of Pharyngeal Gonorrhea and Commensal Neisseria Species in the Emergence of Antimicrobial Resistance in Neisseria Gonorrhoeae: Data Gaps and Future Research
咽部淋病与共生奈瑟菌属在淋病奈瑟菌耐药性出现中作用的循证评估：数据缺口与未来研究
Amber D Kimble and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 983–994, https://doi.org/10.1093/infdis/jiag197
Major Articles and Brief Reports（论著与简报）
HIV/AIDs（人类免疫缺陷病毒/艾滋病）
5
Frailty in People with HIV Is Linked to Inflammation, Bone Health, and T-Cell Exhaustion
HIV感染者的衰弱与炎症、骨健康及T细胞耗竭相关
Michael L Freeman and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 995–1004, https://doi.org/10.1093/infdis/jiag046
6
A New Type of Nonsuppressible Viremia Produced by HIV-Infected Macrophage
HIV感染巨噬细胞产生的一种新型不可抑制性病毒血症
Matthew J Moeser and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 1005–1014, https://doi.org/10.1093/infdis/jiag171
Viral Disease Pathogenesis（病毒性疾病发病机制）
7
Immune Checkpoint Inhibitor-Induced Rapid Decline in Hepatitis B Virus Markers Improves the Prognosis of Hepatitis B Virus–Related Hepatocellular Carcinoma Patients
免疫检查点抑制剂诱导的乙型肝炎病毒标志物快速下降改善乙肝相关肝细胞癌患者的预后
Yujie Ran and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 1015–1026, https://doi.org/10.1093/infdis/jiag036
8
Nasal Biomarkers of Acute Illness Severity and Predictors of Recurrent Wheeze in Infants Infected With Respiratory Syncytial Virus
呼吸道合胞病毒感染婴儿的急性疾病严重程度的鼻部生物标志物及反复喘息的预测因素
Mary T Caserta and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 1027–1035, https://doi.org/10.1093/infdis/jiag049
9
Epidemiological, Clinical, and Virological Characterizations of Yezo Virus Infections, an Emerging Tick-borne Orthonairovirus Disease in Japan
日本新兴蜱传正内罗病毒病——耶佐病毒感染的流行病学、临床及病毒学特征
Hiroki Yamaguchi and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 1036–1045, https://doi.org/10.1093/infdis/jiag073
10
Single-Cell Sequencing Reveals Varying Cell-Mediated Immunity Profiles in Individuals With Distinct Antibody Responses Following Ad5-nCoV Booster
单细胞测序揭示Ad5-nCoV加强针接种后不同抗体应答者的细胞免疫谱差异
Conghui Liao and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 1046–1057, https://doi.org/10.1093/infdis/jiag078
11
Middle East Respiratory Syndrome Coronavirus–Specific T-Cell Responses in Dromedary Camel Abattoir Workers in Nigeria Suggests Frequent Zoonotic Spillover
尼日利亚单峰驼屠宰场工人中中东呼吸综合征冠状病毒特异性T细胞反应提示频繁的人畜共患溢出
Chris K P Mok and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 1058–1062, https://doi.org/10.1093/infdis/jiag095
12
Incidence and Severity of Postacute Sequelae of SARS-CoV-2 Infection in the Omicron Era: A Prospective Cohort Study
奥密克戎时代SARS-CoV-2感染后急性后遗症的发生率与严重程度：一项前瞻性队列研究
Dan-Yu Lin and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 1063–1068, https://doi.org/10.1093/infdis/jiag026
Bacterial Disease Pathogenesis（细菌性疾病发病机制）
13
Real-World Effectiveness of Sequential Pneumococcal Vaccination in Older Adults: A Cohort Study
老年人序贯肺炎球菌疫苗接种的现实有效性：一项队列研究
Yong Yi Tan and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 1069–1080, https://doi.org/10.1093/infdis/jiag147
14
Safety and Immunogenicity of a Trivalent Salmonella Conjugate Vaccine to S. Typhi, S. Typhimurium, and S. Enteritidis
针对伤寒沙门氏菌、鼠伤寒沙门氏菌和肠炎沙门氏菌的三价沙门氏菌结合疫苗的安全性与免疫原性
Wilbur H Chen and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 1081–1090, https://doi.org/10.1093/infdis/jiag156
15
The Natural History of Mycoplasma genitalium in the Pharynx and Rectum in a Cohort of Men Who Have Sex With Men: Prevalence, Incidence, Duration, and Symptoms
生殖支原体在男男性行为者咽部和直肠中的自然史：患病率、发病率、持续时间及症状
Lindley A Barbee and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 1091–1099, https://doi.org/10.1093/infdis/jiag173
16
A Genomic Analysis of Community-Associated C. difficile Infection Demonstrates Integration With National and International Strain Clusters and Limited Direct Transmission
社区相关性艰难梭菌感染的基因组分析显示其与国内外菌株簇的整合及有限的直接传播
Nicole D Pecora and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 1100–1109, https://doi.org/10.1093/infdis/jiag176
Antimicrobial Resistance (AMR)（抗生素耐药）
17
Recurrent Plasmodium falciparum Parasitemia and Drug Resistance Mutations During Intermittent Preventive Treatment of Malaria in Pregnancy in Uganda
乌干达妊娠期疟疾间歇性预防治疗期间恶性疟原虫复现及耐药突变
Jimmy Kizza and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 1110–1119, https://doi.org/10.1093/infdis/jiag074
18
Stepwise Evolution of Triple Antimicrobial Resistance in Neisseria meningitidis
脑膜炎奈瑟菌三重耐药性的逐步演化
José Eduardo O Marín and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 1120–1129, https://doi.org/10.1093/infdis/jiag113
19
Asymptomatic Screening for Neisseria gonorrhoeae Among Gay and Bisexual Men Attending Public Sexual Health Services in Australia and Associations With Patterns of Ceftriaxone Consumption: A Retrospective Observational Study
澳大利亚男男性行为者在公共性健康服务机构中淋病奈瑟菌无症状筛查及其与头孢曲松消费模式的关联：一项回顾性观察研究
Arthur Wong and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages 1130–1140, https://doi.org/10.1093/infdis/jiag192
Editorial（社论）
20
Cytomegalovirus and Aging—How Can the Field Move Forward?
巨细胞病毒与衰老——该领域如何向前推进？
Michael Boeckh and Lawrence Corey
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1307–e1309, https://doi.org/10.1093/infdis/jiag099
21
New Insights From Perinatal HIV: A Way Forward for HIV Cure Research
围产期HIV的新见解——HIV治愈研究的前进方向
Rajesh T Gandhi and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1310–e1312, https://doi.org/10.1093/infdis/jiag057
ID Translational Science Update（传染病转化医学最新动态）
22
What's Hot in HIV in 2025—A Basic and Translational Science Review From IDWeek 2025
2025年HIV研究热点——IDWeek 2025基础与转化医学综述
Ana Rafaela Teixeira and Marina Caskey
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1313–e1319, https://doi.org/10.1093/infdis/jiag135
Major Articles and Brief Reports（论著与简报）
Viruses（病毒）
23
A Pathogen Penalty? Associations Between Persistent Infections and Biological Aging in the US
病原体惩罚？美国持续感染与生物学衰老之间的关联
Jennifer Momkus and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1320–e1329, https://doi.org/10.1093/infdis/jiaf606
24
Transient Interferon-Driven Natural Killer Cell Activation in Acute Hepatitis C
急性丙型肝炎中一过性干扰素驱动的自然杀伤细胞激活
Benedikt Strunz and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1330–e1340, https://doi.org/10.1093/infdis/jiaf654
25
Risk-Based Prophylactic Human Papillomavirus Vaccination of Heterosexual US Men Aged 27 to 45 Years for Prevention of Oropharyngeal Cancer
基于风险用以预防口咽癌的美国男性27至45岁异性恋人群预防性人乳头瘤病毒疫苗接种
Anil K Chaturvedi and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1341–e1344, https://doi.org/10.1093/infdis/jiag038
26
Machine Learning–Enabled Quantification of Hepatocellular Necrosis in the Liver After Lethal Marburg and Ebola Virus Exposures
机器学习辅助定量分析致死性马尔堡病毒和埃博拉病毒暴露后肝脏肝细胞坏死程度
Yanling Liu and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1345–e1354, https://doi.org/10.1093/infdis/jiag040
27
Influenza Vaccination Effectiveness Against Influenza-Associated Hospitalization in Children and the Effects of Repeated Vaccination
流感疫苗对儿童流感相关住院的有效性及重复接种的影响
Xuan Yu and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1355–e1363, https://doi.org/10.1093/infdis/jiag047
28
Repeat Influenza Vaccination Effects in 2021/22 and 2022/23 in a Community-Based Cohort in Hong Kong
2021/22及2022/23季香港社区队列中重复接种流感疫苗的效果
Jennifer C Zhong and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1364–e1373, https://doi.org/10.1093/infdis/jiag051
29
Anti-spike IgG Avidity Enhances Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2: A Prospective Study of Primary Infections and Immunizations
抗刺突蛋白IgG亲合力增强对严重急性呼吸综合征冠状病毒2的中和作用：初次感染与免疫接种的前瞻性研究
Visa Nurmi and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1374–e1385, https://doi.org/10.1093/infdis/jiag068
30
Genomic Evolution of Influenza A Virus During the 2024–2025 Season, the Johns Hopkins Health System: Antigenic Drift Reduces Serum Neutralization
2024—2025季约翰斯·霍普金斯卫生系统中甲型流感病毒的基因组进化：抗原漂移降低血清中和能力
David Villafuerte and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1386–e1395, https://doi.org/10.1093/infdis/jiag069
HIV/AIDs（人类免疫缺陷病毒/艾滋病）
31
Dynamics of Intact and Defective Human Immunodeficiency Virus Type 1 (HIV-1) Proviruses During Decades of Suppressive Antiretroviral Treatment in Young Adults With Perinatal HIV
围产期感染HIV青年人在数十年抑制性抗逆转录病毒治疗期间完整与缺陷型人类免疫缺陷病毒1型（HIV-1）前病毒的动态变化
Priya Khetan and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1396–e1406, https://doi.org/10.1093/infdis/jiag045
32
Unsuppressed Viremia and Lower CD4 Count Associated With Faster Telomere Attrition in African Children With Perinatal Human Immunodeficiency Virus on Long-term Antiretroviral Therapy
未抑制的病毒血症及较低CD4计数与长期接受抗逆转录病毒治疗的非洲围产期感染HIV的儿童端粒加速缩短相关
Julian P G Shellard and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1407–e1417, https://doi.org/10.1093/infdis/jiag060
33
Limited Sex-Based Differences in Viral Outcomes of ART-Treated SIV/SHIV Infection
ART治疗的SIV/SHIV感染中病毒学结局的性别差异有限
Kedan Endrias and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1418–e1422, https://doi.org/10.1093/infdis/jiag064
34
Mitochondrial Haplogroups and Left Ventricular Diastolic Dysfunction in People Living With and Without HIV
线粒体单倍群与HIV感染者及非感染者的左心室舒张功能障碍
Craig Cronin and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1423–e1432, https://doi.org/10.1093/infdis/jiag090
Bacterial Disease Pathogenesis（细菌性疾病发病机制）
35
Cefazolin Inoculum Effect and Cefazolin Microbiological Treatment Failure in Serious Methicillin-Susceptible Staphylococcus aureus Infections: A Multicenter Retrospective Cohort Study
甲氧西林敏感金黄色葡萄球菌严重感染中头孢唑林接种效应与微生物学治疗失败：一项多中心回顾性队列研究
Mitchell A Jeffs and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1433–e1442, https://doi.org/10.1093/infdis/jiag199
36
Investigation of Correlates of Protection Against Gonococcal Infection by Comparative Immunoprofiling of Responses in Experimental and Clinical Studies
通过实验和临床研究中免疫反应的比较分析，探究淋球菌感染保护的相关因素
Samantha A McKeand and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1443–e1453, https://doi.org/10.1093/infdis/jiag216
Parasites（寄生虫）
37
Schistosoma mansoni Infections Are Associated With Fecal Calprotectin Markers of Gut Inflammation After Accounting for HIV, Hepatitis B, and Malaria
在控制HIV、乙型肝炎和疟疾因素后，曼氏血吸虫感染与肠道炎症粪便钙卫蛋白标志物相关
Lauren Wilburn and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1454–e1464, https://doi.org/10.1093/infdis/jiag094
38
Expelling of Plasmodium falciparum Sporozoites by Anopheles stephensi Mosquitoes During Repeated Feeding
按蚊在反复吸血过程中驱逐恶性疟原虫子孢子
Chiara Andolina and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1465–e1469, https://doi.org/10.1093/infdis/jiag130
39
Predicting Risk of Plasmodium Vivax Microscopy-Detected Episodes Using Serological Markers in Patients With Plasmodium falciparum Malaria: A Multicountry Diagnostic Performance Evaluation
利用血清学标志物预测恶性疟原虫疟疾患者中间日疟原虫镜检检出发作的风险：一项多国诊断效能评估
Maulina Hafidzah and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1470–e1479, https://doi.org/10.1093/infdis/jiag164
40
Hidden Infections, Emerging Resistance: Underdiagnosed Plasmodium vivax and Multidrug Resistance-1 (pvmdr1) Gene Amplification in the Guiana Shield
隐匿感染，耐药新兴：圭亚那盾区漏诊的间日疟原虫及多药耐药基因1（pvmdr1）基因扩增
Maria Carolina Silva de Barros Puça and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1480–e1489, https://doi.org/10.1093/infdis/jiag196
Fungi（真菌）
41
Treatment Monitoring and Outcome Prediction in Invasive Aspergillosis Using Immunologic Markers
利用免疫学标志物监测侵袭性曲霉病的治疗效果及预后预测
Ana Pereira and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1490–e1499, https://doi.org/10.1093/infdis/jiag140
42
MHC-I Upregulation and Increased Glucose Dependence Define Innate Antifungal Immune Responses to Cryptococcus neoformans
MHC-I上调及葡萄糖依赖性增加是针对新型隐球菌的先天抗真菌免疫应答的特征
Ayesha S Nair and Karen L Wozniak
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1500–e1510, https://doi.org/10.1093/infdis/jiag144
Letters to the Editor（致编辑的信）
43
Infectious Disease Risk Management in Body Donation Programs
遗体捐献项目中的传染病风险管理
Brandi Schmitt and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1511–e1512, https://doi.org/10.1093/infdis/jiaf579
44
In Response to Schmitt et al: Data Do Not Support Exclusionary Policies
回应Schmitt等人：数据不支持排斥性政策
Sara Gianella and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1513–e1515, https://doi.org/10.1093/infdis/jiaf580
45
CXCR6 in the Blood Is Not the Liver: Clarifying NK-Cell “Homing” and Postcure ADCC Imprints in Acute Hepatitis C
血液中的CXCR6不等于肝脏：澄清急性丙型肝炎中NK细胞"归巢"及治愈后ADCC印迹
Anxin Wen
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1516–e1517, https://doi.org/10.1093/infdis/jiag044
46
Holding One Another in a Time of Loss and Uncertainty
在失去与不确定的时代中彼此守望
Sara Gianella
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1518–e1519, https://doi.org/10.1093/infdis/jiag110
47
Comment on “Comparative Analysis of High-Dose Dual Therapies in First-Line Helicobacter pylori Eradication: An Inverse Probability of Treatment-Weighted Multicenter Study”
评《高剂量双联方案一线根除幽门螺杆菌的比较分析：一项基于逆概率治疗加权的多中心研究》
Guofu Mao and others
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1520–e1521, https://doi.org/10.1093/infdis/jiag139
Corrections（勘误）
48
Correction to: Epidemiology and Risk Factors of Norovirus Infections Among Diarrhea Patients Admitted to Tertiary Care Hospitals in Bangladesh
勘误：孟加拉国三级医院腹泻住院患者中诺如病毒感染的流行病学及危险因素
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Page e1522, https://doi.org/10.1093/infdis/jiag234
49
Correction to: Rickettsia rickettsii subsp californica subsp nov, the Etiologic Agent of Pacific Coast Tick Fever
勘误：立克次体加州亚种新亚种——太平洋海岸蜱传热的病原体
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Pages e1523–e1524, https://doi.org/10.1093/infdis/jiag016
50
Correction to: Hybrid B- and T-Cell Immunity Associates With Protection Against Breakthrough Infection After Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in Avon Longitudinal Study of Parents and Children (ALSPAC) Participants
勘误：杂合B细胞和T细胞免疫与严重急性呼吸综合征冠状病毒2疫苗接种后突破性感染的保护相关——艾文纵向父母与儿童研究（ALSPAC）参与者分析
The Journal of Infectious Diseases, Volume 233, Issue 6, 15 June 2026, Page e1525, https://doi.org/10.1093/infdis/jiag161
100 项与 磷坦姆沙韦 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| HIV感染 | 美国 | 2020-07-02 |
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10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 终末期肾脏病 | 临床1期 | 美国 | 2016-02-26 |
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临床结果
临床结果
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| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床3期 | 272 | Fostemsavir + optimized background therapy | 憲憲襯壓餘願餘網獵構(襯繭窪繭鹹遞簾觸憲襯) = mean increase, +0.24, CD4+/CD8+ ratio ≥0.45 increased from 9% (25/272) at baseline to 40% (85/213) at week 96. 獵廠積窪夢蓋製醖構醖 (廠衊餘構淵廠繭鑰選願 ) 更多 | 积极 | 2024-08-30 | ||
临床3期 | HIV感染 multidrug-resistant HIV-1 | 371 | Fostemsavir + Optimized Background Therapy | 繭壓鏇範窪夢簾願糧製(鑰憲膚繭顧獵網廠鑰餘) = COVID-19-related events occurred in 25 out of 371 participants; all resolved without incident. Four participants discontinued for adverse events, one additional participant experienced a drug-related serious adverse event, and six deaths occurred (median last available CD4+ T-cell count, 3 cells/mm^3) 繭壓獵衊選鬱餘夢鏇繭 (鏇淵顧獵繭夢觸築範醖 ) | 积极 | 2023-09-01 | |
Placebo | |||||||
临床3期 | 371 | Fostemsavir plus optimized background therapy | 築鬱選蓋鬱積壓憲襯願(築襯願窪窪顧遞夢製願) = 顧選鏇範壓製齋鏇願鹹 鑰壓觸艱蓋顧積鹽衊願 (廠構膚夢遞選鏇遞鹽鏇 ) | 积极 | 2022-05-03 | ||
Optimized background therapy | 築鬱選蓋鬱積壓憲襯願(築襯願窪窪顧遞夢製願) = 窪選繭積襯鏇衊餘選餘 鑰壓觸艱蓋顧積鹽衊願 (廠構膚夢遞選鏇遞鹽鏇 ) | ||||||
临床3期 | - | 371 | (Randomized cohort) | 鏇製獵鹽簾獵鹽積蓋範(積艱醖鏇鹽齋壓鏇壓顧) = 鏇網廠遞憲製簾廠鹹廠 觸簾範餘憲蓋壓遞鹹膚 (鏇艱蓋鏇餘顧簾壓廠窪 ) | - | 2021-06-28 | |
(Nonrandomized cohort) | 鏇製獵鹽簾獵鹽積蓋範(積艱醖鏇鹽齋壓鏇壓顧) = 繭醖網廠壓獵觸鑰築構 觸簾範餘憲蓋壓遞鹹膚 (鏇艱蓋鏇餘顧簾壓廠窪 ) | ||||||
临床3期 | - | 371 | 醖鬱範醖鬱築顧構觸繭(餘選鑰範簾積築夢簾淵) = 願憲鹹範廠築鑰醖衊窪 選窪製餘鹽繭繭製壓網 (選築襯獵鑰網繭觸廠積 ) | 积极 | 2020-11-01 | ||
Placebo | 醖鬱範醖鬱築顧構觸繭(餘選鑰範簾積築夢簾淵) = 鏇衊獵鹹鏇餘鏇積廠淵 選窪製餘鹽繭繭製壓網 (選築襯獵鑰網繭觸廠積 ) | ||||||
临床3期 | 371 | 窪築繭鹹選衊窪製構齋(網醖糧製夢鑰憲網夢膚) = 觸製壓糧壓觸願鹹憲鹹 選獵壓積築憲醖範獵積 (襯構鹽餘積築衊淵選憲 ) | 积极 | 2020-03-26 | |||
Placebo | 窪築繭鹹選衊窪製構齋(網醖糧製夢鑰憲網夢膚) = 獵繭壓築膚壓夢遞廠簾 選獵壓積築憲醖範獵積 (襯構鹽餘積築衊淵選憲 ) | ||||||
临床2期 | 50 | (BMS-663068 600 mg Q12H + RTV 100 mg Q12H) | 醖淵憲網構淵齋醖鹽夢(齋網鹽範範製築憲蓋壓) = 蓋壓製獵糧積願憲簾網 觸醖範襯製願構夢廠鏇 (糧築築鹹衊獵範鏇網鹹, 0.07925) 更多 | - | 2020-01-03 | ||
(BMS-663068 1200 mg QHS + RTV 100 mg QHS) | 醖淵憲網構淵齋醖鹽夢(齋網鹽範範製築憲蓋壓) = 製壓衊網鏇鹽鏇簾醖構 觸醖範襯製願構夢廠鏇 (糧築築鹹衊獵範鏇網鹹, 0.10610) 更多 | ||||||
N/A | - | 製醖繭廠願糧窪壓襯簾(鑰簾築糧窪範鹽繭艱鹹) = 選願夢願窪願鑰繭艱憲 壓窪構衊網繭鹽製顧鹹 (製鏇觸夢窪鹹糧選選壓 ) 更多 | - | 2019-01-01 | |||
Placebo | 製醖繭廠願糧窪壓襯簾(鑰簾築糧窪範鹽繭艱鹹) = 糧蓋觸築壓鏇遞製選鑰 壓窪構衊網繭鹽製顧鹹 (製鏇觸夢窪鹹糧選選壓 ) 更多 | ||||||
N/A | - | - | Fostemsavir-containing regimens | 糧膚鏇廠網製襯膚廠願(鏇鬱積鹽膚顧鹽積衊簾) = 7% discontinued due to AE 構壓積蓋觸壓網繭構遞 (簾網襯鹹鑰窪鑰構觸範 ) 更多 | - | 2019-01-01 | |
临床2期 | 254 | FTR+TDF+RAL (FTR 400 mg BID/RAL/TDF) | 窪積夢構膚願築齋簾積 = 壓夢夢齋構鹽鏇願蓋艱 鏇鬱廠艱夢願鹹夢襯積 (製遞願餘淵鏇築醖積築, 夢築顧鑰選鏇廠鬱窪廠 ~ 遞積選膚夢窪襯餘鏇壓) 更多 | - | 2018-11-14 | ||
FTR+TDF+RAL (FTR 800 mg BID/RAL/TDF) | 窪積夢構膚願築齋簾積 = 衊憲憲醖願醖鑰醖網衊 鏇鬱廠艱夢願鹹夢襯積 (製遞願餘淵鏇築醖積築, 鑰膚廠鏇廠鏇構窪憲觸 ~ 鏇齋鏇壓淵齋醖壓憲積) 更多 |
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