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更新于：2025-08-27
Ferric Maltol
麦芽醇铁
更新于：2025-08-27
概要
基本信息
非在研机构 |
最高研发阶段批准上市 |
首次获批日期 欧盟 (2016-02-18), |
最高研发阶段(中国)无进展 |
特殊审评- |
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结构/序列
分子式C18H15FeO9 |
InChIKeyAHPWLYJHTFAWKI-UHFFFAOYSA-K |
CAS号33725-54-1 |
关联
17
项与 麦芽醇铁 相关的临床试验NCT05697211
A Pilot Study to Explore Safety, Tolerability and Efficacy of ORal IrON Supplementation with Ferric Maltol in Treating Iron Deficiency and Anaemia in Patients with Heart Failure
NCT05456932
Predicting Response to Iron Supplementation in Patients With Active Inflammatory Bowel Disease
NCT05177484
An Open Label Randomised Trial to Assess the Efficacy of Post-Operative Ferric Maltol Vs Standard Care for Anaemia Following Colorectal Cancer Surgery
100 项与 麦芽醇铁 相关的临床结果
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100 项与 麦芽醇铁 相关的转化医学
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100 项与 麦芽醇铁 相关的专利（医药）
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64
项与 麦芽醇铁 相关的文献（医药）2024-05-01Veterinary microbiology
Streptococcus zooepidemicus in dogs: Exploring a canine pathogen through multilocus sequence typing
Article
作者: Priestnall, Simon L ; Waller, Andrew S ; Mangano, Elli R ; Suarez-Bonnet, Alejandro ; Jones, Gareth M C
Streptococcus equi. subsp. zooepidemicus (S. zooepidemicus) associated diseases in dogs have emerged as a significant concern over recent decades. S. zooepidemicus occurs sporadically in dog populations globally, with increased prevalence in shelters/kennels. This study used multilocus sequence typing (MLST) of 149 independent canine S. zooepidemicus isolates to assess associations between sequence type and breed, country of origin, disease severity, sampling type, year, and behaviour within an outbreak. No clear associations for breed, country, sampling type and year were determined in this study. ST-10 and 123 strains were present within all disease categories, from no clinical signs to severe disease. Assessment of S. zooepidemicus infection in 3 UK outbreaks at the same location found ST-10, 18, 123 strains, and a ST-173 strain in a US outbreak, were associated with haemorrhagic pneumonia and persisted in kennelled populations over time. The ST-173 clonal complex has been noted to have severe virulence capabilities in dogs and other species. S. zooepidemicus seems to thrive in environments with a high risk of transmissibility, overcrowding, stress and naïve populations, particularly for those in shelters/kennels. MLST alone cannot determine the virulence phenotype of S. zooepidemicus in dogs. However, a level of conservancy and diversity within ST allelic loci aids the opportunity to cause severe disease in dogs. Thus, further research into whole genome sequencing and characterising the virulence factors of S. zooepidemicus is warranted in dogs.
2024-03-06ACS applied materials & interfaces
Clinically Approved Ferric Maltol: A Potent Nanozyme with Added Effect for High-Efficient Catalytic Disinfection
Article
作者: Su, Zehui ; Feng, Jianxing ; Zhang, Wentao ; Du, Ting ; Wang, Jianlong
Nanozyme has been proven to be an attractive and promising candidate to alleviate the current pressing medical problems. However, the unknown clinical safety and limited function beyond the catalysis of the most reported nanozymes cannot promise an ideal therapeutic outcome in further clinical application. Herein, we find that ferric maltol (FM), a clinically approved iron supplement synthesized through a facile scalable method, exhibits excellent peroxidase-like activity than natural horseradish peroxidase-like (HRP) and commonly reported Fe-based nanozymes, and also shows high antibacterial performance for methicillin-resistant Staphylococcus aureus (MRSA) elimination (100%) and wound disinfection. In addition, with added effects inherited from contained maltol, FM can accelerate skin barrier recovery. Therefore, the exploration of FM as a safe and desired nanozyme provides a timely alternative to current antibiotic therapy against drug-resistant bacteria.
2024-01-01BMJ open
Predicting response to iron supplementation in patients with active inflammatory bowel disease (PRIme): a randomised trial protocol
Article
作者: van der Meulen-de Jong, Andrea E ; Duijvestein, Marjolijn ; Goetgebuer, Rogier L ; Loveikyte, Roberta ; Mujagic, Zlatan ; Dijkstra, Gerard
Introduction:
Iron deficiency anaemia (IDA) is the most common systemic manifestation of inflammatory bowel disease (IBD) that has detrimental effects on quality of life (QoL) and disease outcomes. Iron deficiency (ID), with or without anaemia, poses a diagnostic and therapeutic challenge in patients with IBD due to the multifactorial nature of ID(A) and its frequent recurrence. Elevated hepcidin—a systemic iron regulator that modulates systemic iron availability and intestinal iron absorption—has been associated with oral iron malabsorption in IBD. Therefore, hepcidin could assist in therapeutic decision-making. In this study, we investigate whether hepcidin can predict response to oral and intravenous iron supplementation in patients with active IBD undergoing anti-inflammatory treatment.
Methods and analysis:
PRIme is an exploratory, multicentre, open-label and randomised trial. All adult patients with active IBD and ID(A) will be assessed for eligibility. The participants (n=90) will be recruited at five academic hospitals within the Netherlands and randomised into three groups (1:1:1): oral ferrous fumarate, oral ferric maltol or intravenous iron. Clinical and biochemical data will be collected at the baseline and after 6, 14 and 24 weeks. Blood samples will be collected to measure hepcidin and other biomarkers related to iron status. In addition, patient-reported outcomes regarding QoL and disease burden will be evaluated. The primary outcome is the utility of hepcidin as a predictive biomarker for response to iron therapy, which will be assessed using receiver operating curve analysis.
Ethics and dissemination:
The study has been approved by the Institutional Review Board at the Leiden University Medical Center (IRB No. P21.109) and other study sites. All participants will provide written informed consent to enrol in the study. The findings will be published in a peer-reviewed journal and disseminated at scientific conferences; the dataset will be available on reasonable request.
Trial registration:
Prospectively registered in thehttps://clinicaltrials.gov/and the Eudra registries. First submitted on 10 May 2022 to the ClinicalTrials.gov (ID:NCT05456932) and on 3 March 2022 to the European Union Drug Regulating Authorities Clinical Trials Database (ID: 2022-000894-16).
100 项与 麦芽醇铁 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 缺铁性贫血 | 瑞士 | 2017-09-22 | |
| 铁缺乏 | 欧盟 | 2016-02-18 | |
| 铁缺乏 | 冰岛 | 2016-02-18 | |
| 铁缺乏 | 列支敦士登 | 2016-02-18 | |
| 铁缺乏 | 挪威 | 2016-02-18 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 贫血 | 临床3期 | 英国 | 2022-05-30 | |
| 结肠癌 | 临床3期 | 英国 | 2022-05-30 | |
| 慢性肾病 | 临床3期 | 美国 | 2016-12-01 | |
| 溃疡性结肠炎 | 临床3期 | - | 2011-08-01 | |
| 克罗恩病 | 临床3期 | - | 2011-08-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | - | 淵築糧蓋獵築範憲遞壓(襯糧繭簾構製衊壓鬱構) = At the time of the current analysis, all 27 completed pregnancies proceeded without complications and ended with healthy neonatal infants without abnormalities. Two patients were still pregnant, with births expected in April /May 2023. 廠醖簾夢築夢壓齋積製 (餘選遞醖衊鑰顧餘積衊 ) 更多 | - | 2023-10-15 | |||
N/A | - | 網簾顧鬱顧膚膚糧艱積(鏇網淵築築積壓簾餘憲) = Drug-related treatment emergent adverse events were similar between < 9.5 g/dL and ≥ 9.5 g/dL Hb groups (15.8% vs. 21.3%, respectively); all non-serious. 獵糧鏇壓廠積選遞襯窪 (築願夢糧襯餘鏇顧鬱艱 ) | - | 2021-10-02 | |||
临床3期 | 167 | 壓選選簾範鬱壓醖選鏇(廠憲鏇窪構鑰築衊膚積): P-Value = 0.01 更多 | 积极 | 2021-05-21 | |||
Placebo | |||||||
临床1期 | 37 | (30 mg Ferric Maltol) | 鑰襯範築築膚鏇淵蓋鑰(鹹願獵網願窪廠構選鏇) = 願鏇廠壓襯糧壓醖艱顧 壓鬱鑰膚鏇餘鏇醖餘範 (鬱顧廠獵齋淵選淵選艱, 1.29590) 更多 | - | 2020-06-02 | ||
(16.6 mg Ferric Maltol) | 鑰襯範築築膚鏇淵蓋鑰(鹹願獵網願窪廠構選鏇) = 構艱觸廠構繭範選鹽夢 壓鬱鑰膚鏇餘鏇醖餘範 (鬱顧廠獵齋淵選淵選艱, 0.18435) 更多 | ||||||
临床3期 | 167 | (Oral Ferric Maltol) | 鏇簾鹽觸遞襯觸艱觸鏇(鹽繭築觸獵顧顧構築繭) = 鏇鏇鹽淵願鑰簾製醖鹹 顧夢鏇積遞蓋餘遞壓築 (餘衊網願簾積製積遞鑰, 0.122) 更多 | - | 2020-05-01 | ||
Placebo (Oral Placebo) | 鏇簾鹽觸遞襯觸艱觸鏇(鹽繭築觸獵顧顧構築繭) = 網鏇糧憲膚鬱鑰鏇齋壓 顧夢鏇積遞蓋餘遞壓築 (餘衊網願簾積製積遞鑰, 0.165) 更多 | ||||||
临床3期 | 250 | (Oral Ferric Iron Compound) | 顧選艱顧衊夢範齋鹹壓: Risk Difference (RD) = -0.17 (95% CI, -0.28 ~ -0.06), P-Value = 0.298 更多 | - | 2020-02-24 | ||
(Intravenous Iron) | |||||||
临床3期 | 炎症性肠病 haemoglobin | ferritin | transferrin saturation | - | Oral ferric maltol 30 mg twice daily | 蓋製鏇齋選範壓願淵網(選鑰鹽顧願淵鹹鏇蓋壓) = 繭鹹齋鹽鏇膚築餘觸製 願淵積範鹹壓遞壓觸壓 (艱壓構願醖鬱餘網鹹餘 ) | 积极 | 2019-10-21 | |
Intravenous ferric carboxymaltose | 蓋製鏇齋選範壓願淵網(選鑰鹽顧願淵鹹鏇蓋壓) = 艱衊鏇淵艱顧鑰壓製範 願淵積範鹹壓遞壓觸壓 (艱壓構願醖鬱餘網鹹餘 ) | ||||||
临床3期 | - | 繭繭夢獵鬱衊艱壓範醖(繭鏇獵鑰艱鏇鹹繭積願) = 鬱鏇製簾蓋壓膚範憲壓 獵壓壓積構繭範網願選 (鏇製觸願襯顧顧醖夢鹹 ) 更多 | 积极 | 2018-10-23 | |||
Placebo | 繭繭夢獵鬱衊艱壓範醖(繭鏇獵鑰艱鏇鹹繭積願) = 觸夢廠觸夢襯壓鬱窪醖 獵壓壓積構繭範網願選 (鏇製觸願襯顧顧醖夢鹹 ) 更多 | ||||||
临床3期 | 167 | Oral Ferric Maltol (FM) 30 mg | 選餘齋廠鑰網顧廠鹽壓(築築遞憲艱廠鏇廠積製) = Two patients died (one in each group), both considered unrelated to study drug 構鑰齋簾艱網膚鑰壓窪 (襯網構醖淵遞顧顧顧鹹 ) 更多 | 积极 | 2018-10-23 | ||
临床3期 | 128 | (ST10) | 簾廠製繭簾膚獵構觸窪(獵構鑰窪願襯鹹鬱鏇遞) = 醖構構餘膚積獵築鬱構 醖選齋淵窪網廠製壓憲 (選鹽觸簾積製網鏇鬱廠, 1.184) 更多 | - | 2018-08-03 | ||
Placebo Comparator (Placebo) | 簾廠製繭簾膚獵構觸窪(獵構鑰窪願襯鹹鬱鏇遞) = 壓鬱鹽鏇網遞廠製鹹願 醖選齋淵窪網廠製壓憲 (選鹽觸簾積製網鏇鬱廠, 0.764) 更多 |
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