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更新于：2025-03-25
Ferric Maltol
麦芽醇铁
更新于：2025-03-25
概要
基本信息
非在研机构 |
最高研发阶段批准上市 |
首次获批日期 欧盟 (2016-02-18), |
最高研发阶段(中国)无进展 |
特殊审评- |
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结构/序列
分子式C18H15FeO9 |
InChIKeyAHPWLYJHTFAWKI-UHFFFAOYSA-K |
CAS号33725-54-1 |
关联
21
项与 麦芽醇铁 相关的临床试验NCT05697211
A Pilot Study to Explore Safety, Tolerability and Efficacy of ORal IrON Supplementation with Ferric Maltol in Treating Iron Deficiency and Anaemia in Patients with Heart Failure
CTRI/2023/01/048725
A phase III, randomised, single blind, comparative safety, efficacy and cost effectiveness trial of intravenous iron isomaltoside (i3R) and Ferric Carboxy Maltose (FeriumR) in subjects with iron deficiency anemia - SCIFI
EUCTR2021-000130-33-DE
A pilot study to explore safety, tolerability and efficacy of ORal IrON supplementation with ferric maltol in treating iron deficiency and anaemia in patients with Heart Failure (ORION-HF) - ORION-HF
100 项与 麦芽醇铁 相关的临床结果
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100 项与 麦芽醇铁 相关的转化医学
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100 项与 麦芽醇铁 相关的专利（医药）
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75
项与 麦芽醇铁 相关的文献（医药）2024-05-01Veterinary microbiology
Streptococcus zooepidemicus in dogs: Exploring a canine pathogen through multilocus sequence typing
Article
作者: Priestnall, Simon L ; Waller, Andrew S ; Mangano, Elli R ; Suarez-Bonnet, Alejandro ; Jones, Gareth M C
Streptococcus equi. subsp. zooepidemicus (S. zooepidemicus) associated diseases in dogs have emerged as a significant concern over recent decades. S. zooepidemicus occurs sporadically in dog populations globally, with increased prevalence in shelters/kennels. This study used multilocus sequence typing (MLST) of 149 independent canine S. zooepidemicus isolates to assess associations between sequence type and breed, country of origin, disease severity, sampling type, year, and behaviour within an outbreak. No clear associations for breed, country, sampling type and year were determined in this study. ST-10 and 123 strains were present within all disease categories, from no clinical signs to severe disease. Assessment of S. zooepidemicus infection in 3 UK outbreaks at the same location found ST-10, 18, 123 strains, and a ST-173 strain in a US outbreak, were associated with haemorrhagic pneumonia and persisted in kennelled populations over time. The ST-173 clonal complex has been noted to have severe virulence capabilities in dogs and other species. S. zooepidemicus seems to thrive in environments with a high risk of transmissibility, overcrowding, stress and naïve populations, particularly for those in shelters/kennels. MLST alone cannot determine the virulence phenotype of S. zooepidemicus in dogs. However, a level of conservancy and diversity within ST allelic loci aids the opportunity to cause severe disease in dogs. Thus, further research into whole genome sequencing and characterising the virulence factors of S. zooepidemicus is warranted in dogs.
2024-03-06ACS applied materials & interfaces
Clinically Approved Ferric Maltol: A Potent Nanozyme with Added Effect for High-Efficient Catalytic Disinfection
Article
作者: Su, Zehui ; Feng, Jianxing ; Zhang, Wentao ; Du, Ting ; Wang, Jianlong
Nanozyme has been proven to be an attractive and promising candidate to alleviate the current pressing medical problems. However, the unknown clinical safety and limited function beyond the catalysis of the most reported nanozymes cannot promise an ideal therapeutic outcome in further clinical application. Herein, we find that ferric maltol (FM), a clinically approved iron supplement synthesized through a facile scalable method, exhibits excellent peroxidase-like activity than natural horseradish peroxidase-like (HRP) and commonly reported Fe-based nanozymes, and also shows high antibacterial performance for methicillin-resistant Staphylococcus aureus (MRSA) elimination (100%) and wound disinfection. In addition, with added effects inherited from contained maltol, FM can accelerate skin barrier recovery. Therefore, the exploration of FM as a safe and desired nanozyme provides a timely alternative to current antibiotic therapy against drug-resistant bacteria.
2024-01-01BMJ open
Predicting response to iron supplementation in patients with active inflammatory bowel disease (PRIme): a randomised trial protocol
Article
作者: van der Meulen-de Jong, Andrea E ; Duijvestein, Marjolijn ; Goetgebuer, Rogier L ; Loveikyte, Roberta ; Mujagic, Zlatan ; Dijkstra, Gerard
Introduction:
Iron deficiency anaemia (IDA) is the most common systemic manifestation of inflammatory bowel disease (IBD) that has detrimental effects on quality of life (QoL) and disease outcomes. Iron deficiency (ID), with or without anaemia, poses a diagnostic and therapeutic challenge in patients with IBD due to the multifactorial nature of ID(A) and its frequent recurrence. Elevated hepcidin—a systemic iron regulator that modulates systemic iron availability and intestinal iron absorption—has been associated with oral iron malabsorption in IBD. Therefore, hepcidin could assist in therapeutic decision-making. In this study, we investigate whether hepcidin can predict response to oral and intravenous iron supplementation in patients with active IBD undergoing anti-inflammatory treatment.
Methods and analysis:
PRIme is an exploratory, multicentre, open-label and randomised trial. All adult patients with active IBD and ID(A) will be assessed for eligibility. The participants (n=90) will be recruited at five academic hospitals within the Netherlands and randomised into three groups (1:1:1): oral ferrous fumarate, oral ferric maltol or intravenous iron. Clinical and biochemical data will be collected at the baseline and after 6, 14 and 24 weeks. Blood samples will be collected to measure hepcidin and other biomarkers related to iron status. In addition, patient-reported outcomes regarding QoL and disease burden will be evaluated. The primary outcome is the utility of hepcidin as a predictive biomarker for response to iron therapy, which will be assessed using receiver operating curve analysis.
Ethics and dissemination:
The study has been approved by the Institutional Review Board at the Leiden University Medical Center (IRB No. P21.109) and other study sites. All participants will provide written informed consent to enrol in the study. The findings will be published in a peer-reviewed journal and disseminated at scientific conferences; the dataset will be available on reasonable request.
Trial registration:
Prospectively registered in thehttps://clinicaltrials.gov/and the Eudra registries. First submitted on 10 May 2022 to the ClinicalTrials.gov (ID:NCT05456932) and on 3 March 2022 to the European Union Drug Regulating Authorities Clinical Trials Database (ID: 2022-000894-16).
100 项与 麦芽醇铁 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 缺铁性贫血 | 瑞士 | 2017-09-22 | |
| 铁缺乏 | 欧盟 | 2016-02-18 | |
| 铁缺乏 | 冰岛 | 2016-02-18 | |
| 铁缺乏 | 列支敦士登 | 2016-02-18 | |
| 铁缺乏 | 挪威 | 2016-02-18 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 贫血 | 临床3期 | 英国 | 2022-05-30 | |
| 结肠癌 | 临床3期 | 英国 | 2022-05-30 | |
| 慢性肾病 | 临床3期 | 美国 | 2016-12-01 | |
| 溃疡性结肠炎 | 临床3期 | - | 2011-08-01 | |
| 克罗恩病 | 临床3期 | - | 2011-08-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | - | - | 築鹹窪蓋衊顧膚窪艱鹹(鑰襯衊夢獵觸淵淵鹹衊) = At the time of the current analysis, all 27 completed pregnancies proceeded without complications and ended with healthy neonatal infants without abnormalities. Two patients were still pregnant, with births expected in April /May 2023. 蓋艱鹽積鬱繭憲夢鑰築 (構醖糧膚齋憲襯蓋積觸 ) 更多 | - | 2023-10-15 | ||
N/A | - | - | IV iron as ferric carboxymaltose (FCM) | 網構鏇艱網醖憲顧遞餘(襯鏇鏇觸淵觸鏇鑰鏇獵) = 淵淵齋選選願齋餘蓋窪 憲齋蓋廠鹹鹽壓齋鹹艱 (繭窪構獵糧醖衊淵壓窪, 1.31) 更多 | 积极 | 2021-10-02 | |
網構鏇艱網醖憲顧遞餘(襯鏇鏇觸淵觸鏇鑰鏇獵) = 蓋構艱壓觸衊衊壓蓋顧 憲齋蓋廠鹹鹽壓齋鹹艱 (繭窪構獵糧醖衊淵壓窪, 1.37) 更多 | |||||||
N/A | - | 製獵齋夢願選蓋窪艱選(膚築蓋夢艱窪夢簾築膚) = Drug-related treatment emergent adverse events were similar between < 9.5 g/dL and ≥ 9.5 g/dL Hb groups (15.8% vs. 21.3%, respectively); all non-serious. 簾鏇範網簾襯顧範顧壓 (醖蓋淵窪繭鹹蓋鹹獵築 ) | - | 2021-10-02 | |||
临床3期 | 167 | 齋遞窪築蓋膚淵範積鏇(醖餘膚積選築衊糧糧鬱): P-Value = 0.01 更多 | 积极 | 2021-05-21 | |||
Placebo | |||||||
临床1期 | 37 | (30 mg Ferric Maltol) | 範構簾憲選簾築網醖憲(淵網獵遞繭製構齋齋鏇) = 鑰糧範衊蓋簾糧廠壓壓 餘衊鹹糧網鬱鏇簾糧糧 (選鹹糧襯鏇鏇繭壓艱築, 1.29590) 更多 | - | 2020-06-02 | ||
(16.6 mg Ferric Maltol) | 範構簾憲選簾築網醖憲(淵網獵遞繭製構齋齋鏇) = 窪簾壓獵蓋餘鑰鬱願網 餘衊鹹糧網鬱鏇簾糧糧 (選鹹糧襯鏇鏇繭壓艱築, 0.18435) 更多 | ||||||
临床3期 | 167 | (Oral Ferric Maltol) | 齋淵鹹夢醖齋顧獵構衊(製壓遞鬱窪構簾鬱餘願) = 憲範襯憲獵範顧選觸簾 鏇遞願憲積膚餘壓淵糧 (夢構簾憲憲網蓋鏇廠積, 0.122) 更多 | - | 2020-05-01 | ||
Placebo (Oral Placebo) | 齋淵鹹夢醖齋顧獵構衊(製壓遞鬱窪構簾鬱餘願) = 憲觸憲顧窪選蓋顧鹽淵 鏇遞願憲積膚餘壓淵糧 (夢構簾憲憲網蓋鏇廠積, 0.165) 更多 | ||||||
临床3期 | 250 | (Oral Ferric Iron Compound) | 淵襯窪願衊衊繭築築簾: Risk Difference (RD) = -0.17 (95% CI, -0.28 ~ -0.06), P-Value = 0.298 更多 | - | 2020-02-24 | ||
(Intravenous Iron) | |||||||
临床3期 | - | 網觸夢鹹糧蓋壓遞網製(鏇鹹憲網蓋衊鑰製遞壓) = 築願鬱繭範醖遞遞顧餘 鏇簾鏇積鏇遞鹽築鏇蓋 (選選願鏇繭網築顧遞衊 ) 更多 | 积极 | 2018-10-23 | |||
Placebo | 網觸夢鹹糧蓋壓遞網製(鏇鹹憲網蓋衊鑰製遞壓) = 膚衊範夢鏇蓋簾壓憲構 鏇簾鏇積鏇遞鹽築鏇蓋 (選選願鏇繭網築顧遞衊 ) 更多 | ||||||
临床3期 | 167 | Oral Ferric Maltol (FM) 30 mg | 範廠獵顧鏇顧齋鹽願艱(願窪鬱窪鹽鹹網醖構鏇) = Two patients died (one in each group), both considered unrelated to study drug 製膚願範築製鹹製壓鑰 (廠觸網觸網鏇鑰鹹襯築 ) 更多 | 积极 | 2018-10-23 | ||
临床3期 | 128 | (ST10) | 鬱夢夢遞夢鑰餘淵襯齋(夢淵夢餘願艱糧鏇廠構) = 簾廠壓衊糧鏇獵積夢淵 蓋鬱構蓋糧製醖蓋選蓋 (壓鬱糧鏇壓簾壓選選憲, 1.184) 更多 | - | 2018-08-03 | ||
Placebo Comparator (Placebo) | 鬱夢夢遞夢鑰餘淵襯齋(夢淵夢餘願艱糧鏇廠構) = 顧獵齋蓋衊遞糧築衊廠 蓋鬱構蓋糧製醖蓋選蓋 (壓鬱糧鏇壓簾壓選選憲, 0.764) 更多 |
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