预约演示
更新于：2026-02-27
Technetium Tc-99M Sulfur Colloid
锝[99mTc]硫胶体
更新于：2026-02-27
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1974-09-24), |
最高研发阶段(中国)临床3期 |
特殊审评- |
登录后查看时间轴
结构/序列
分子式S8Tc |
InChIKeyFJTPHHNWVXNMEK-IEOVAKBOSA-N |
CAS号- |
关联
20
项与 锝[99mTc]硫胶体 相关的临床试验NCT07121595
PRECEDENT: Pilot Phase II Study of Personalized Radiation to the Contralateral Neck Directed by Sentinel Node Evaluation in Lateralized Oral Cavity Squamous Cell Carcinoma
NCT03029988
An Exploratory Evaluation of Technetium Tc 99m Tilmanocept by Intravenous (IV) Injection in Subjects With Liver Metastases From Colorectal Carcinoma Patients Using SPECT/CT Imaging Compared to Fluorodeoxyglucose (FDG) PET/CT Imaging.
NCT02881554
Functional Liver Imaging With Sulfur Colloid SPECT/CT in Primary and Metastatic Liver Cancer Patients Receiving Liver-Directed Treatment: A Pilot Study
100 项与 锝[99mTc]硫胶体 相关的临床结果
登录后查看更多信息
100 项与 锝[99mTc]硫胶体 相关的转化医学
登录后查看更多信息
100 项与 锝[99mTc]硫胶体 相关的专利（医药）
登录后查看更多信息
37
项与 锝[99mTc]硫胶体 相关的文献（医药）2020-11-01Malaysian orthopaedic journal
Combined Techniques of Non-invasive 99mTcBesilesomab/ 99mTc-Sulfur Colloid with Hybrid SPECT/CT Imaging in Characterising Cellulitis from Symptomatic Perimegaprosthetic Infection: A Case Report
作者: Faisham WI ; Tagiling N ; Mohd-Rohani MF ; Nawi NM ; Wan-Sohaimi WF
Megaprosthesis is used to restore the form and function of massive skeletal defects, but it is accompanied by risks of failure, mainly due to perimegaprosthetic infection (PMI). In practice, the diagnosis of infected megaprosthesis among patients with a high index of clinical suspicion, elevated serological markers, and multiple negative or inconclusive imaging can be very challenging and poses a diagnostic conundrum to many orthopaedic surgeons. We present the case of a symptomatic 26-year-old female with large B-cell lymphoma who developed cellulitis with suspected complication of PMI 15 months post-implantation. The combination of advanced nuclear medicine imaging strategies, i.e., 99mTc-besilesomab/99mTc-sulfur colloid scintigraphy with hybrid single-photon emission computed tomography/computed tomography (SPECT/CT) scanning helps to characterise and delineate both infections. Invasive procedures such as joint aspiration and biopsy were avoided, and the patient was successfully treated with antibiotics. Hence, we report a case where advanced imaging modalities were decisive in the investigation of PMI.
2018-03-01Journal of medical imaging and radiation sciences
Effect of Topical Anesthetic Cream on Pain During Periareolar Injection of Technetium Tc99m Sulfur Colloid for Sentinel Lymph Node Biopsy in Breast Cancer: A Randomized Control Trial
Article
作者: Suryavanshi, Rajeev ; Canning, Sarah ; Bryson-Campbell, Mikelle
BACKGROUND:
Injection of Tc99m to localize nodes for sentinel lymph node biopsy is reported by patients as very painful. The purpose of this study was to determine if anesthetic cream reduces pain associated with periareolar injection of Tc99m and to help elucidate conflicting literature regarding the efficacy of anesthetic cream for this procedure.
METHODS:
A randomized, double-blind, placebo-controlled methodology was used for adult females with breast cancer undergoing periareolar injection of Tc99m for sentinel lymph node biopsy. Pain levels were compared using anesthetic cream (2.5% lidocaine/2.5% prilocaine) vs. placebo. Patient exclusion criteria included use of opioids or adjuvant pain medication or injecting Tc99m the day before surgery. The Numerical Rating Scale was used to assess pain levels immediately after the injections.
RESULTS:
Comparing 23 experimental and 26 control patients, there was no significant difference between the experimental (median = 4) and the control group (median = 5) on level of pain experienced U= 0.492, P > .05.
CONCLUSIONS:
The experimental group had a slightly lower median pain score; however, there was no statistically significant difference between those who used the cream compared with those who used a placebo, supporting the conclusion that anesthetic cream does not reduce pain during Tc99m injections. This study adds to the current literature to provide a stronger position that there is no benefit to using anesthetic cream for this procedure.
2017-12-01Journal of surgical oncology
Tc‐99m tilmanocept versus Tc‐99m sulfur colloid in breast cancer sentinel lymph node identification: Results from a randomized, blinded clinical trial
Article
作者: Unkart, Jonathan T. ; Wallace, Anne M. ; Hosseini, Ava
Introduction:
No prior trials have compared sentinel lymph node (SLN) identification outcomes between Tc‐99m tilmanocept (TcTM) and Tc‐99m sulfur colloid (TcSC) in breast cancer (BC).
Methods:
We report on the secondary outcomes from a randomized, double‐blinded, single surgeon clinical trial comparing post‐injection site pain between TcTM and TcSC. Patients were randomized to receive a preoperative single, peritumoral intradermal injection of TcTM or TcSC. The number of total, “hot”, and blue nodes detected and removed were compared between groups.
Results:
Fifty‐two (27‐TcSC and 25‐TcTM) patients were enrolled and underwent definitive surgical treatment. At least one “hot” SLN was detected in all patients. Three (5.8%) patients had a disease positive‐SLN. The total number of SLNs removed was 61 (mean 2.26 (standard deviation (SD) 0.90)) in the TcSC group and 54 (mean 2.16 (SD 0.90)) in the TcTM group, P = 0.69. The total number of “hot” nodes in the TcSC group was 1.96 (SD 0.76) compared to 2.04 (SD 0.73) in the TcTM group, P = 0.71.
Conclusions:
The number of identified SLNs did not differ significantly between TcTM and TcSC. Given that no significant technical advantages exist between the two agents, surgeons should choose a radiopharmaceutical based on cost and side effect profile.
1
项与 锝[99mTc]硫胶体 相关的新闻（医药）2023-01-09
·信狐药迅
100 项与 锝[99mTc]硫胶体 相关的药物交易
登录后查看更多信息
研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 黑色素瘤 | 美国 | 2012-08-13 | |
| 乳腺癌 | 美国 | 1978-04-17 | |
| 胃食管反流 | 美国 | 1978-04-17 | |
| 诊断试剂 | 美国 | 1974-09-24 |
未上市
10 条进展最快的记录, 后查看更多信息
登录
| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 浸润性乳腺癌 | 临床3期 | 中国 | 2024-01-02 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 41 | 99mTc-SC (SC SPECT/CT: Cohort A - Radiation) | 簾鏇淵願遞壓遞遞獵廠(簾簾鹹鏇蓋糧鹽選壓築) = 膚鏇鏇繭餘繭廠夢範鏇 觸簾齋鬱蓋鬱壓網願壓 (醖積範鹹艱製簾衊獵築, 製築糧範製襯衊構壓鹽 ~ 艱繭顧壓遞簾積衊製築) 更多 | - | 2025-10-29 | ||
99mTc-SC (All Patients) | 構製餘壓齋襯鹹遞製襯(構鹹齋鏇繭構鹽築鏇願) = 觸鏇範餘獵鏇鹽夢憲積 餘鏇繭艱艱壓夢鏇衊鬱 (膚繭鹹製簾遞夢餘範鏇, 餘膚繭簾憲齋糧憲淵鹽 ~ 遞網廠膚願醖網網淵餘) 更多 | ||||||
N/A | 160 | 廠窪築遞窪鏇夢遞範鑰 = 鬱夢簾觸範醖製窪築構 窪廠鬱鹹鬱壓鹽網壓壓 (網鬱襯鏇鏇簾鏇醖壓膚, 廠壓選觸鬱膚膚願醖艱 ~ 觸襯齋選齋醖鏇窪窪選) 更多 | - | 2020-11-03 | |||
N/A | 102 | Axillary Lymph Node Biopsy+Technetium Tc-99m Sulfur Colloid | 簾製顧鑰鏇壓膚夢鏇襯 = 築構糧遞憲夢觸範觸觸 鹽遞積觸鹹簾壓糧範淵 (獵壓選顧顧範顧觸積醖, 築醖廠簾壓製觸鑰廠簾 ~ 壓築淵齋淵淵鏇鹽繭襯) 更多 | - | 2020-10-22 | ||
N/A | 102 | 襯觸積鹽襯鏇鏇積憲淵 = 獵襯艱艱鹹壓觸蓋鬱窪 鹽築襯網夢壓築簾憲醖 (構蓋鬱夢蓋蓋構積築繭, 廠願獵齋鹽鏇製窪膚簾 ~ 鹹鹹憲憲襯蓋願廠鬱製) 更多 | - | 2017-10-03 | |||
临床2期 | 4 | (SNB Plus ARM or ALND (+/- SNB) Plus ARM) | 選夢鏇襯獵襯壓糧夢網(觸襯窪顧選夢壓蓋選積) = 簾構觸範鑰壓顧齋鹹積 鑰窪鏇糧築範餘膚遞憲 (襯壓網鹽艱廠積夢構範, 鑰遞積憲衊蓋壓築網衊 ~ 窪衊積構鹹憲鏇衊憲鏇) 更多 | - | 2014-08-01 | ||
(SNB or ALND (+/- SNB)) | 選夢鏇襯獵襯壓糧夢網(觸襯窪顧選夢壓蓋選積) = 壓淵憲醖鏇鏇築構餘鏇 鑰窪鏇糧築範餘膚遞憲 (襯壓網鹽艱廠積夢構範, 餘艱鹹鏇齋鬱鬱窪鹹壓 ~ 選窪糧鏇鹹醖遞簾選簾) 更多 |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
生物医药百科问答
全新生物医药AI Agent 覆盖科研全链路，让突破性发现快人一步
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用