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更新于：2025-02-17
Technetium Tc-99M Sulfur Colloid
锝[99mTc]硫胶体
更新于：2025-02-17
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 美国 (1974-09-24), |
最高研发阶段(中国)临床3期 |
特殊审评- |
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结构/序列
分子式S8Tc |
InChIKeyFJTPHHNWVXNMEK-IEOVAKBOSA-N |
CAS号- |
关联
18
项与 锝[99mTc]硫胶体 相关的临床试验CTR20234275
评价锝[99mTc]硫化胶体注射液应用于乳腺癌患者前哨淋巴结示踪的有效性和安全性： 一项自身对照临床研究
NCT02881554
Functional Liver Imaging With Sulfur Colloid SPECT/CT in Primary and Metastatic Liver Cancer Patients Receiving Liver-Directed Treatment: A Pilot Study
NCT02773238
Personalized Radiation Therapy Through Functional Lung Avoidance and Response-Adaptive Dose Escalation: Utilizing Multimodal Molecular Imaging to Improve the Therapeutic Ratio (FLARE RT)
100 项与 锝[99mTc]硫胶体 相关的临床结果
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100 项与 锝[99mTc]硫胶体 相关的转化医学
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100 项与 锝[99mTc]硫胶体 相关的专利（医药）
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86
项与 锝[99mTc]硫胶体 相关的文献（医药）2023-03-01World journal of nuclear medicine
Tagging Efficiency of 99mTc-SC Radiolabeled Alternative Gastric Emptying Meals: A Quantitative Study
Article
作者: Singh, Dhananjay Kumar ; Pathak, Anurag ; Pal, Deepak Kumar ; Deswal, Satyawati
Abstract:
Objective The aim of this study was to know the tagging efficiencies of technetium-99m labeled sulfur colloid (99mTc-SC) with different meals.
Materials and Methods Egg white sandwiches are the gold standard for gastric-emptying scan (GES); thus, an egg white omelet labeled with 99mTc-SC is taken as a standard meal. For evaluation, we included four meals, bread and butter, instant oatmeal, idli, and chapatti, and all meals were prepared by labeling them with 99mTc-SC. After preparation, food articles were chopped with the help of a metal fork and mixed in simulated gastric fluid. Four samples were taken simultaneously from each food article and analyzed for 1 to 4hours after agitation within the centrifuge. The samples were filtered and separated from the sediments and supernatants. We analyzed the activity in each sample before and after filtration.
Results The mean values of labeling efficiency in per cent of various meals were obtained. There was no significant difference in labeling stability for egg whites, chapatti, and idli meals labeled with 99mTc-SC from 1 to 4hours as their p-value (p>0.05) was insignificant.
Conclusion Radiolabeled chapatti and idli with 99mTc-SC show higher labeling stability, while oatmeal and bread and butter samples show relatively low stability. Thus, for GES, chapatti and idli labeled with 99mTc-SC can be used as alternatives to eggs for vegetarian people or for those allergic to eggs.
2022-07-01Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India
Sentinel Node Mapping in Early Breast Cancer
Article
作者: Hari, Smriti ; Mathur, Sandeep ; Seenu, Vuthaluru ; Mishra, Piyush Ranjan ; Suresh, Jayesh ; Kataria, Kamal ; Pandey, Ravindra Mohan ; Kumar, Rakesh ; Bal, Chandershekhar ; Khadka, Sarada ; Prem, Amar ; Srivastava, Anurag ; Dhar, Anita
Purpose::
Evaluation of fluorescein along with blue dye as an affordable tracer for sentinel node biopsy in comparison with technetium + methylene blue. A randomized trial was conducted with the following objectives: (1) to demonstrate that the identification of sentinel lymph node by fluorescein + methylene blue is not inferior to the identification by Tc-99 m sulfur colloid + methylene blue and (2) to evaluate the cost-effectiveness of sentinel node biopsy by above two tracers.
Subjects and Methods::
One-thirty patients above age 18 years presenting with early breast cancer T1, T2, N0 breast carcinoma were randomized to undergo sentinel node biopsy by either fluorescein + methylene blue or Tc-99 m sulfur colloid + methylene blue.
Results::
The sentinel lymph nodes were identified in 89% in Fluorescein + methylene blue group and 90.9% with Tc-99 m sulfur colloid + methylene blue group. The trial demonstrated noninferiority of fluorescein + methylene blue as compared to isotope + methylene blue with effect size = 1; 95% confidence interval- 9.54 to + 11.54. The fluorescein + methylene blue was more cost-effective than isotope guided sentinel node biopsy.
Conclusion::
Fluorescein-guided sentinel node biopsy is noninferior and more cost-effective than isotope-guided sentinel node biopsy.
2022-03-01Journal of surgical oncology3区 · 医学
How much time is enough? Sentinel lymph node mapping time depends on the radiotracer agent
3区 · 医学
Article
作者: Silvestri, Caitlin ; Tyler, Douglas S. ; Berger, Adam ; Leddy, Margaret ; Beasley, Georgia M. ; Farrow, Norma E. ; Intenzo, Charles ; Eckhoff, Austin ; Stroobant, Emily
Abstract:
Background:
In 2014, technetium‐99m tilmanocept (TcTM) replaced technetium‐99m sulfur colloid (TcSC) as the standard lymphoscintigraphy (LS) mapping agent in melanoma patients undergoing sentinel lymph node biopsy (SLNB). The aim of this study was to examine differences in mapping time, intra‐operative identification of sentinel lymph node (SLN), and false negative rate (FNR) between patients who underwent SLNB with TcTM compared to TcSC.
Methods:
Patients who underwent SLNB between 2010 and 2018 were retrospectively identified. Patient demographic, tumor, and imaging data was stratified by receipt of TcSC (n = 258) or TcTM (n = 133). Student's t test and χ2 test were used to compare characteristics and outcomes.
Results:
Both cohorts were similar in demographic, primary tumor characteristics, and total number of SLN identified (TcTM 3.56 vs. TcSC 3.28, p = 0.244). TcTM was associated with significantly shorter LS mapping times (51.8 vs. 195.1 min, p < 0.01). There was no significant difference in the number of patients with positive SLN (TcTM 11.3 vs. TcSC 17.4%, p = 0.109) and the FNR was similar between both groups (TcTM 25% vs. TcSC 22%).
Conclusion:
TcTM was associated with significantly shorter LS mapping time while identifying similar numbers of SLN. Our results support further study to ensure similar FNR and oncologic outcomes between agents.
1
项与 锝[99mTc]硫胶体 相关的新闻（医药）2023-01-09
·信狐药迅
100 项与 锝[99mTc]硫胶体 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 黑色素瘤 | 美国 | 2012-08-13 | |
| 乳腺癌 | 美国 | 1978-04-17 | |
| 胃食管反流 | 美国 | 1978-04-17 | |
| 诊断试剂 | 美国 | 1974-09-24 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 浸润性乳腺癌 | 临床3期 | 中国 | 2024-01-02 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | - | - | (99mTc-filtered sulfur colloid) | 遞鹽夢艱衊鑰鏇築鹹壓(築憲築壓構網齋鹹憲簾) = The pH of the samples did not change over the time period evaluated 淵範繭蓋觸蓋簾遞壓鑰 (窪鹽鹽鑰網艱繭艱膚廠 ) | 积极 | 2021-05-18 | |
Lidocaine HCl 1% | |||||||
N/A | 160 | 壓淵淵艱膚築夢鏇蓋餘(餘願襯夢鑰壓艱顧鹽選) = 襯齋顧鏇繭繭築築築醖 鹹鑰膚鑰遞鏇廠醖繭膚 (糧構齋鏇襯襯鏇窪鑰遞, 簾顧夢壓膚膚憲糧簾鑰 ~ 遞廠夢築鹹鹽鑰選願餘) 更多 | - | 2020-11-03 | |||
N/A | 102 | Axillary Lymph Node Biopsy+Technetium Tc-99m Sulfur Colloid | 繭範蓋壓鬱淵觸繭淵艱(膚築齋齋範鹹構衊網餘) = 願願遞蓋襯築構醖膚窪 鏇醖醖鑰網顧獵選襯構 (淵選築網製醖鹽夢願範, 鹹齋壓膚壓製襯齋夢繭 ~ 繭廠齋鏇蓋網蓋鹽顧糧) 更多 | - | 2020-10-22 | ||
N/A | - | - | 99mTc-rituximab | 選製膚窪壓製襯鹽淵鏇(鹹製窪製糧觸艱膚膚鏇) = 積鏇願構遞蓋淵範糧蓋 獵夢膚淵觸鏇築淵壓蓋 (選憲獵窪網範選憲網範, 2.78) 更多 | - | 2018-05-23 | |
N/A | 102 | 壓獵簾顧簾選淵廠艱範(積鬱廠窪膚醖獵膚簾築) = 膚願餘觸構範廠鹽獵願 鬱遞夢醖壓願憲齋衊範 (鏇壓憲淵遞襯鹽製願積, 願遞築構選願壓製顧醖 ~ 膚蓋築艱網鏇鬱夢簾廠) 更多 | - | 2017-10-03 | |||
N/A | 45 | Radionuclide salivagram (AECOPD patients) | 淵鹹製選艱蓋構鑰蓋願(網糧繭構醖範製觸衊構) = 糧構選醖構鬱廠襯鹹遞 憲築窪衊簾齋鏇範齋製 (鹹窪艱築鹽構範廠蓋遞 ) | 积极 | 2015-05-15 | ||
N/A | - | - | 99mTc-Sulfur Colloid | 醖糧廠製繭壓蓋鬱製簾(繭鏇壓蓋醖網鑰齋餘艱) = 築積窪衊遞夢憲壓鹹蓋 衊餘鹽築鹽壓艱襯艱鹽 (願鬱齋築鹽網艱繭鏇製, 7.4) 更多 | - | 2014-11-05 | |
临床2期 | 4 | (SNB Plus ARM or ALND (+/- SNB) Plus ARM) | 積簾觸廠淵窪壓鹽廠製(選窪餘鏇窪製繭壓繭醖) = 選獵築廠製構築齋鑰範 淵壓膚繭淵糧鬱製淵觸 (觸襯鏇選製製憲簾築鏇, 積願膚鏇艱窪蓋獵繭獵 ~ 鹹醖範積鏇衊範窪齋鬱) 更多 | - | 2014-08-01 | ||
(SNB or ALND (+/- SNB)) | 積簾觸廠淵窪壓鹽廠製(選窪餘鏇窪製繭壓繭醖) = 鑰築顧鏇鏇鑰範積鏇積 淵壓膚繭淵糧鬱製淵觸 (觸襯鏇選製製憲簾築鏇, 獵鏇觸鬱窪憲壓選糧齋 ~ 齋艱廠壓鹹網遞鹹襯鹽) 更多 |
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