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更新于：2025-01-16
Technetium Tc-99M Sulfur Colloid
锝[99mTc]硫胶体
更新于：2025-01-16
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 美国 (1974-09-24), |
最高研发阶段(中国)临床3期 |
特殊审评- |
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结构/序列
分子式S8Tc |
InChIKeyFJTPHHNWVXNMEK-IEOVAKBOSA-N |
CAS号- |
关联
5
项与 锝[99mTc]硫胶体 相关的临床试验CTR20234275
评价锝[99mTc]硫化胶体注射液应用于乳腺癌患者前哨淋巴结示踪的有效性和安全性： 一项自身对照临床研究
NCT02881554
Functional Liver Imaging With Sulfur Colloid SPECT/CT in Primary and Metastatic Liver Cancer Patients Receiving Liver-Directed Treatment: A Pilot Study
NCT02336737
A Pivotal, Prospective, Open-Label, Multicenter Paired Comparison Study Of SentiMag/SiennaXP And The Standard Of Care In Patients With Breast Cancer Who Are Undergoing Lymph Node Mapping As Part Of A Sentinel Node Biopsy Procedure
100 项与 锝[99mTc]硫胶体 相关的临床结果
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100 项与 锝[99mTc]硫胶体 相关的转化医学
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100 项与 锝[99mTc]硫胶体 相关的专利（医药）
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86
项与 锝[99mTc]硫胶体 相关的文献（医药）2023-03-01World journal of nuclear medicine
Tagging Efficiency of 99mTc-SC Radiolabeled Alternative Gastric Emptying Meals: A Quantitative Study
Article
作者: Singh, Dhananjay Kumar ; Pathak, Anurag ; Pal, Deepak Kumar ; Deswal, Satyawati
Abstract:
Objective The aim of this study was to know the tagging efficiencies of technetium-99m labeled sulfur colloid (99mTc-SC) with different meals.
Materials and Methods Egg white sandwiches are the gold standard for gastric-emptying scan (GES); thus, an egg white omelet labeled with 99mTc-SC is taken as a standard meal. For evaluation, we included four meals, bread and butter, instant oatmeal, idli, and chapatti, and all meals were prepared by labeling them with 99mTc-SC. After preparation, food articles were chopped with the help of a metal fork and mixed in simulated gastric fluid. Four samples were taken simultaneously from each food article and analyzed for 1 to 4hours after agitation within the centrifuge. The samples were filtered and separated from the sediments and supernatants. We analyzed the activity in each sample before and after filtration.
Results The mean values of labeling efficiency in per cent of various meals were obtained. There was no significant difference in labeling stability for egg whites, chapatti, and idli meals labeled with 99mTc-SC from 1 to 4hours as their p-value (p>0.05) was insignificant.
Conclusion Radiolabeled chapatti and idli with 99mTc-SC show higher labeling stability, while oatmeal and bread and butter samples show relatively low stability. Thus, for GES, chapatti and idli labeled with 99mTc-SC can be used as alternatives to eggs for vegetarian people or for those allergic to eggs.
2022-07-01Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India
Sentinel Node Mapping in Early Breast Cancer
Article
作者: Hari, Smriti ; Mathur, Sandeep ; Seenu, Vuthaluru ; Mishra, Piyush Ranjan ; Suresh, Jayesh ; Kataria, Kamal ; Pandey, Ravindra Mohan ; Kumar, Rakesh ; Bal, Chandershekhar ; Khadka, Sarada ; Prem, Amar ; Srivastava, Anurag ; Dhar, Anita
Purpose::
Evaluation of fluorescein along with blue dye as an affordable tracer for sentinel node biopsy in comparison with technetium + methylene blue. A randomized trial was conducted with the following objectives: (1) to demonstrate that the identification of sentinel lymph node by fluorescein + methylene blue is not inferior to the identification by Tc-99 m sulfur colloid + methylene blue and (2) to evaluate the cost-effectiveness of sentinel node biopsy by above two tracers.
Subjects and Methods::
One-thirty patients above age 18 years presenting with early breast cancer T1, T2, N0 breast carcinoma were randomized to undergo sentinel node biopsy by either fluorescein + methylene blue or Tc-99 m sulfur colloid + methylene blue.
Results::
The sentinel lymph nodes were identified in 89% in Fluorescein + methylene blue group and 90.9% with Tc-99 m sulfur colloid + methylene blue group. The trial demonstrated noninferiority of fluorescein + methylene blue as compared to isotope + methylene blue with effect size = 1; 95% confidence interval- 9.54 to + 11.54. The fluorescein + methylene blue was more cost-effective than isotope guided sentinel node biopsy.
Conclusion::
Fluorescein-guided sentinel node biopsy is noninferior and more cost-effective than isotope-guided sentinel node biopsy.
2022-03-01Journal of surgical oncology3区 · 医学
How much time is enough? Sentinel lymph node mapping time depends on the radiotracer agent
3区 · 医学
Article
作者: Silvestri, Caitlin ; Tyler, Douglas S. ; Berger, Adam ; Leddy, Margaret ; Beasley, Georgia M. ; Farrow, Norma E. ; Intenzo, Charles ; Eckhoff, Austin ; Stroobant, Emily
Abstract:
Background:
In 2014, technetium‐99m tilmanocept (TcTM) replaced technetium‐99m sulfur colloid (TcSC) as the standard lymphoscintigraphy (LS) mapping agent in melanoma patients undergoing sentinel lymph node biopsy (SLNB). The aim of this study was to examine differences in mapping time, intra‐operative identification of sentinel lymph node (SLN), and false negative rate (FNR) between patients who underwent SLNB with TcTM compared to TcSC.
Methods:
Patients who underwent SLNB between 2010 and 2018 were retrospectively identified. Patient demographic, tumor, and imaging data was stratified by receipt of TcSC (n = 258) or TcTM (n = 133). Student's t test and χ2 test were used to compare characteristics and outcomes.
Results:
Both cohorts were similar in demographic, primary tumor characteristics, and total number of SLN identified (TcTM 3.56 vs. TcSC 3.28, p = 0.244). TcTM was associated with significantly shorter LS mapping times (51.8 vs. 195.1 min, p < 0.01). There was no significant difference in the number of patients with positive SLN (TcTM 11.3 vs. TcSC 17.4%, p = 0.109) and the FNR was similar between both groups (TcTM 25% vs. TcSC 22%).
Conclusion:
TcTM was associated with significantly shorter LS mapping time while identifying similar numbers of SLN. Our results support further study to ensure similar FNR and oncologic outcomes between agents.
1
项与 锝[99mTc]硫胶体 相关的新闻（医药）2023-01-09
·信狐药迅
100 项与 锝[99mTc]硫胶体 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 黑色素瘤 | 美国 | 2012-08-13 | |
| 乳腺癌 | 美国 | 1978-04-17 | |
| 胃食管反流 | 美国 | 1978-04-17 | |
| 诊断试剂 | 美国 | 1974-09-24 |
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临床结果
临床结果
适应症
分期
评价
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N/A | - | - | (99mTc-filtered sulfur colloid) | 築鏇築遞遞壓膚顧製鏇(鬱積膚淵範窪鹹齋窪蓋) = The pH of the samples did not change over the time period evaluated 遞網選蓋襯顧壓簾餘廠 (顧壓製鏇窪淵選夢積鹹 ) | 积极 | 2021-05-18 | |
Lidocaine HCl 1% | |||||||
N/A | 160 | 鬱築選鏇夢鏇蓋壓蓋餘(範遞網構鏇艱廠襯蓋鑰) = 鏇顧範網願艱鬱襯簾齋 顧選醖遞鬱簾鏇選齋窪 (鏇醖顧構窪襯製鹽廠鬱, 鹽願鹹願築繭簾範範衊 ~ 餘繭獵醖觸醖淵壓顧築) 更多 | - | 2020-11-03 | |||
N/A | - | - | 99mTc-rituximab | 襯築餘窪鬱範衊醖膚淵(選顧選鑰鏇鹹顧鹽選憲) = 齋廠醖膚獵淵鏇選廠襯 襯餘鏇獵壓鏇齋願鏇選 (淵製製積夢窪鬱憲艱鏇, 2.78) 更多 | - | 2018-05-23 | |
N/A | 45 | Radionuclide salivagram (AECOPD patients) | 糧鏇獵廠鏇齋襯淵淵顧(積範蓋憲鑰觸鏇築製餘) = 築齋窪醖醖鬱範願製齋 齋積鑰選夢築願齋鏇夢 (憲鬱鹹膚鏇選壓醖鬱範 ) | 积极 | 2015-05-15 | ||
N/A | - | - | 99mTc-Sulfur Colloid | 齋淵鏇鑰願襯衊壓壓觸(願鹽窪積鑰簾築選網廠) = 繭餘淵鬱壓憲艱壓襯窪 憲鏇構觸鏇簾憲繭夢觸 (繭餘鹽選糧餘顧夢蓋憲, 7.4) 更多 | - | 2014-11-05 |
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