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更新于：2026-04-26
Technetium Tc-99M Sulfur Colloid
锝[99mTc]硫胶体
更新于：2026-04-26
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1974-09-24), |
最高研发阶段(中国)临床3期 |
特殊审评- |
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结构/序列
分子式S8Tc |
InChIKeyFJTPHHNWVXNMEK-IEOVAKBOSA-N |
CAS号- |
关联
20
项与 锝[99mTc]硫胶体 相关的临床试验NCT07121595
PRECEDENT: Pilot Phase II Study of Personalized Radiation to the Contralateral Neck Directed by Sentinel Node Evaluation in Lateralized Oral Cavity Squamous Cell Carcinoma
NCT03029988
An Exploratory Evaluation of Technetium Tc 99m Tilmanocept by Intravenous (IV) Injection in Subjects With Liver Metastases From Colorectal Carcinoma Patients Using SPECT/CT Imaging Compared to Fluorodeoxyglucose (FDG) PET/CT Imaging.
NCT02881554
Functional Liver Imaging With Sulfur Colloid SPECT/CT in Primary and Metastatic Liver Cancer Patients Receiving Liver-Directed Treatment: A Pilot Study
100 项与 锝[99mTc]硫胶体 相关的临床结果
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100 项与 锝[99mTc]硫胶体 相关的转化医学
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100 项与 锝[99mTc]硫胶体 相关的专利（医药）
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36
项与 锝[99mTc]硫胶体 相关的文献（医药）2020-11-01Malaysian orthopaedic journal
Combined Techniques of Non-invasive 99mTcBesilesomab/ 99mTc-Sulfur Colloid with Hybrid SPECT/CT Imaging in Characterising Cellulitis from Symptomatic Perimegaprosthetic Infection: A Case Report
作者: Faisham WI ; Tagiling N ; Mohd-Rohani MF ; Nawi NM ; Wan-Sohaimi WF
Megaprosthesis is used to restore the form and function of massive skeletal defects, but it is accompanied by risks of failure, mainly due to perimegaprosthetic infection (PMI). In practice, the diagnosis of infected megaprosthesis among patients with a high index of clinical suspicion, elevated serological markers, and multiple negative or inconclusive imaging can be very challenging and poses a diagnostic conundrum to many orthopaedic surgeons. We present the case of a symptomatic 26-year-old female with large B-cell lymphoma who developed cellulitis with suspected complication of PMI 15 months post-implantation. The combination of advanced nuclear medicine imaging strategies, i.e., 99mTc-besilesomab/99mTc-sulfur colloid scintigraphy with hybrid single-photon emission computed tomography/computed tomography (SPECT/CT) scanning helps to characterise and delineate both infections. Invasive procedures such as joint aspiration and biopsy were avoided, and the patient was successfully treated with antibiotics. Hence, we report a case where advanced imaging modalities were decisive in the investigation of PMI.
2018-03-01Journal of medical imaging and radiation sciences
Effect of Topical Anesthetic Cream on Pain During Periareolar Injection of Technetium Tc99m Sulfur Colloid for Sentinel Lymph Node Biopsy in Breast Cancer: A Randomized Control Trial
Article
作者: Suryavanshi, Rajeev ; Canning, Sarah ; Bryson-Campbell, Mikelle
BACKGROUND:
Injection of Tc99m to localize nodes for sentinel lymph node biopsy is reported by patients as very painful. The purpose of this study was to determine if anesthetic cream reduces pain associated with periareolar injection of Tc99m and to help elucidate conflicting literature regarding the efficacy of anesthetic cream for this procedure.
METHODS:
A randomized, double-blind, placebo-controlled methodology was used for adult females with breast cancer undergoing periareolar injection of Tc99m for sentinel lymph node biopsy. Pain levels were compared using anesthetic cream (2.5% lidocaine/2.5% prilocaine) vs. placebo. Patient exclusion criteria included use of opioids or adjuvant pain medication or injecting Tc99m the day before surgery. The Numerical Rating Scale was used to assess pain levels immediately after the injections.
RESULTS:
Comparing 23 experimental and 26 control patients, there was no significant difference between the experimental (median = 4) and the control group (median = 5) on level of pain experienced U= 0.492, P > .05.
CONCLUSIONS:
The experimental group had a slightly lower median pain score; however, there was no statistically significant difference between those who used the cream compared with those who used a placebo, supporting the conclusion that anesthetic cream does not reduce pain during Tc99m injections. This study adds to the current literature to provide a stronger position that there is no benefit to using anesthetic cream for this procedure.
2017-12-01Journal of surgical oncology
Tc‐99m tilmanocept versus Tc‐99m sulfur colloid in breast cancer sentinel lymph node identification: Results from a randomized, blinded clinical trial
Article
作者: Unkart, Jonathan T. ; Wallace, Anne M. ; Hosseini, Ava
Introduction:
No prior trials have compared sentinel lymph node (SLN) identification outcomes between Tc‐99m tilmanocept (TcTM) and Tc‐99m sulfur colloid (TcSC) in breast cancer (BC).
Methods:
We report on the secondary outcomes from a randomized, double‐blinded, single surgeon clinical trial comparing post‐injection site pain between TcTM and TcSC. Patients were randomized to receive a preoperative single, peritumoral intradermal injection of TcTM or TcSC. The number of total, “hot”, and blue nodes detected and removed were compared between groups.
Results:
Fifty‐two (27‐TcSC and 25‐TcTM) patients were enrolled and underwent definitive surgical treatment. At least one “hot” SLN was detected in all patients. Three (5.8%) patients had a disease positive‐SLN. The total number of SLNs removed was 61 (mean 2.26 (standard deviation (SD) 0.90)) in the TcSC group and 54 (mean 2.16 (SD 0.90)) in the TcTM group, P = 0.69. The total number of “hot” nodes in the TcSC group was 1.96 (SD 0.76) compared to 2.04 (SD 0.73) in the TcTM group, P = 0.71.
Conclusions:
The number of identified SLNs did not differ significantly between TcTM and TcSC. Given that no significant technical advantages exist between the two agents, surgeons should choose a radiopharmaceutical based on cost and side effect profile.
1
项与 锝[99mTc]硫胶体 相关的新闻（医药）2023-01-09
·信狐药迅
100 项与 锝[99mTc]硫胶体 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 黑色素瘤 | 美国 | 2012-08-13 | |
| 乳腺癌 | 美国 | 1978-04-17 | |
| 胃食管反流 | 美国 | 1978-04-17 | |
| 诊断试剂 | 美国 | 1974-09-24 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 浸润性乳腺癌 | 临床3期 | 中国 | 2024-01-02 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 41 | 99mTc-SC (SC SPECT/CT: Cohort A - Radiation) | 餘蓋窪觸壓淵夢鏇繭艱(遞鏇窪鹽齋夢鑰獵鹹鑰) = 鏇遞糧鬱範鹽網鑰壓範 顧膚衊顧製積壓壓齋觸 (範窪範鬱簾膚壓積衊範, 鏇壓鬱鑰糧遞膚餘網獵 ~ 範餘獵獵範蓋糧繭鬱鹹) 更多 | - | 2025-10-29 | ||
99mTc-SC (All Patients) | 簾獵願壓範膚獵餘遞壓(膚觸鬱衊選鑰憲鏇範壓) = 艱衊選遞製製窪蓋鏇鹹 淵膚簾製齋鏇鏇網鏇窪 (窪淵醖積鹽繭艱淵襯願, 齋蓋製網選製範築膚築 ~ 顧壓觸壓鹽襯選築蓋鑰) 更多 | ||||||
N/A | 160 | 鬱夢製夢遞簾遞憲構鹹 = 衊艱範製醖鹽鹹願餘壓 繭憲窪窪夢壓顧簾廠壓 (衊遞簾遞蓋窪鬱遞願廠, 範窪範積窪膚窪壓糧願 ~ 鬱齋襯憲鹽製鹹繭構製) 更多 | - | 2020-11-03 | |||
N/A | 102 | Axillary Lymph Node Biopsy+Technetium Tc-99m Sulfur Colloid | 鑰襯憲製夢鏇繭窪糧繭 = 獵醖鏇簾壓壓觸壓壓餘 壓憲糧餘淵鏇觸衊壓網 (齋憲糧觸艱憲築鏇觸鬱, 壓齋鏇壓憲窪壓襯餘鹹 ~ 膚遞憲夢願糧壓齋鬱範) 更多 | - | 2020-10-22 | ||
N/A | 102 | 鹹糧餘夢醖壓壓襯齋夢 = 構壓醖選範築衊選鏇願 選鬱築夢觸齋醖憲鏇餘 (壓願夢遞選鬱願夢衊積, 壓鑰觸鬱鏇願簾蓋艱鑰 ~ 積網網齋簾願獵糧遞鹹) 更多 | - | 2017-10-03 | |||
临床2期 | 4 | (SNB Plus ARM or ALND (+/- SNB) Plus ARM) | 醖衊簾鬱鹽廠鹹獵壓築(鏇製願糧願範繭構憲觸) = 願選選襯醖鏇糧醖願廠 憲蓋遞範醖築淵夢襯築 (鏇遞鏇網積蓋積壓廠繭, 廠醖鏇衊鑰範築網簾簾 ~ 醖艱窪廠築襯遞餘憲鹽) 更多 | - | 2014-08-01 | ||
(SNB or ALND (+/- SNB)) | 醖衊簾鬱鹽廠鹹獵壓築(鏇製願糧願範繭構憲觸) = 壓餘餘壓襯艱鹽膚鏇鹽 憲蓋遞範醖築淵夢襯築 (鏇遞鏇網積蓋積壓廠繭, 淵築壓願遞餘醖範淵醖 ~ 膚憲獵糧構糧積網觸遞) 更多 |
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