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更新于：2025-12-25
Isosulfan Blue
异硫蓝
更新于：2025-12-25
概要
基本信息
结构/序列
分子式C27H32N2NaO6S2 |
InChIKeyAVZOEHZTSPLXBS-UHFFFAOYSA-N |
CAS号68238-36-8 |
关联
18
项与 异硫蓝 相关的临床试验CTR20210602
一项多中心、单臂、开放性设计的验证性临床研究评价异硫蓝注射液用于早期乳腺癌患者前哨淋巴结示踪的有效性和安全性
ChiCTR2100046635
A Multi-Center, Single-Arm, Open-Label and Confirmatory Study to Evaluate the Efficacy and Safety of Isosulfan Blue Injection for Sentinel Lymph Node Mapping in Patients with Early Breast Cancer
NCT03927027
ARM: Axillary Reverse Mapping - a Prospective Trial to Study Rates of Lymphedema and Regional Recurrence After Sentinel Lymph Node Biopsy and Sentinel Lymph Node Biopsy Followed by Axillary Lymph Node Dissection with and Without Axillary Reverse Mapping
100 项与 异硫蓝 相关的临床结果
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100 项与 异硫蓝 相关的转化医学
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100 项与 异硫蓝 相关的专利（医药）
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160
项与 异硫蓝 相关的文献（医药）2025-12-02Interventional radiology (Higashimatsuyama-shi (Japan)
Bilateral Subcutaneous Rat Tumor Model Perfused by the Iliolumbar Artery: A Simplified and Versatile Platform for Transarterial Therapy Studies
Article
作者: Gong, Maofeng ; Michimoto, Kenkichi ; Graham, Todd ; Taratula, Oleh ; Farsad, Khashayar ; Yamada, Kentaro ; Suzuki, Takeshi ; Singh, Prem
Purpose: To evaluate the feasibility of a bilateral flank subcutaneous rat tumor model perfused by the iliolumbar artery, as a reproducible platform for preclinical transarterial therapy research. Material and Methods: Eighteen male Lewis rats (median body weight: 295 g; interquartile range: 289-301 g) received bilateral flank implantation of tumor fragments from a pancreatic ductal adenocarcinoma (DSL-6A/C1) that had developed subcutaneously in a donor rat. Upon reaching ≥8 mm in diameter, rats underwent angiography via tail artery access. A microcatheter was advanced into the iliolumbar artery through the aorta, and digital subtraction angiography was used to assess tumor staining. In two animals, either isosulfan blue or fluorescent-labeled nanoparticles were selectively injected via the iliolumbar artery to corroborate radiographic assessment of tumor perfusion. The animal that received fluorescent-labeled nanoparticles was euthanized 24 hours after injection for near-infrared imaging. The remaining rats underwent embolization and were monitored for 72 hours to assess safety. Results: The tumor engraftment rate was 97.2% (35/36). Selective iliolumbar artery catheterization was successful in all rats (100%), with a median procedure time of 20 minutes (interquartile range: 15-25). Digital subtraction angiography confirmed tumor staining in all of the evaluable tumors. Isosulfan blue injection via the iliolumbar artery resulted in whole-tumor staining. Fluorescence imaging revealed higher fluorescent signal intensity in the treated tumor compared with the contralateral side. No major complications, including skin ischemia, claudication, or paralysis were observed. Conclusions: This minimally-invasive model allows for highly reproducible subcutaneous tumor engraftment and reliable selective iliolumbar artery catheterization, providing a straightforward, technically feasible, and practical platform for transarterial therapy studies in rats.
2025-11-01TRANSPLANTATION PROCEEDINGS
Isosulfan Blue and Bladder Disclosure in Kidney Transplant Recipients
Article
作者: Eyvaz, Kemal ; Aslaner, Arif
BACKGROUND:
To evaluate the role of using isosulfan blue via a three-way catheter in performing ureteroneocystostomy in kidney transplant recipients.
METHODS:
A single-center, observational, descriptive study was conducted between December 2015 and July 2024 involving 112 kidney transplant recipients. A three-way catheter was used in all cases, and the bladder volume was assessed using a 1% isosulfan blue solution. Data on recipient demographics, bladder volume, and complications were analyzed.
RESULTS:
A total of 112 patients were included. The mean age of recipients was 48.04 years (range: 25-69). A three-way urinary catheter with physiological saline and isosulfan blue solution was used in all cases. Bladder volume ranged from 50 cc to 250 cc. No intraoperative or postoperative complications were observed.
CONCLUSION:
The use of isosulfan blue through a three-way catheter significantly facilitated the identification of the bladder prior to ureteroneocystostomy, making the procedure easier and more reliable. We recommend the use of isosulfan blue for bladder exposure in kidney transplantation.
2025-09-07Cureus Journal of Medical Science
Intraoperative Anaphylaxis to Isosulfan Blue: Recognizing a Rare but Life-Threatening Reaction
Article
作者: Falatovich, Brianne ; Gologram, Makayla ; Duke, D'Arcy
Isosulfan blue injection (Lymphazurin) is a blue dye injection that is commonly used to map lymphatics in lymphangiography and sentinel lymph node biopsies. A 75-year-old male with a history of hyperlipidemia presented after excision of multiple lesions with plastic surgery, revealing melanoma in situ on the patient's scalp and superficial spreading melanoma with 4 mm margins on the right posterior axilla. During what was expected to be a routine procedure, anesthesia informed the operating room that the patient had become abruptly hypotensive, but responded to a one-time dose of peripheral vasopressors. The patient's chest and face were noticed to be erythematous and edematous when the patient was turned to begin the wide local excision. Welts and hives were noticed to be originating from the area where isosulfan blue was injected. The patient did fully recover from the incident with no unfortunate sequelae, but given this likely anaphylactic event, the patient should never again be exposed to isosulfan blue without direct physician care. Most reactions to isosulfan blue occur on first exposure and, despite its misnomer, have little to no relation to sulfa allergies. This case report and literature review critique the uses and indications for isosulfan blue, as well as discuss the hazards and prevention of these potentially critical reactions.
100 项与 异硫蓝 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 乳糜胸 | 美国 | 1981-07-29 | |
| 乳糜腹 | 美国 | 1981-07-29 | |
| 丝虫性象皮病 | 美国 | 1981-07-29 | |
| 淋巴水肿 | 美国 | 1981-07-29 |
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临床结果
临床结果
适应症
分期
评价
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临床2期 | 24 | 範餘齋鑰網憲選願餘積(積積夢壓蓋網鑰積壓獵) = 齋糧壓艱齋窪齋網遞獵 築鏇齋膚選膚壓構鬱遞 (醖膚廠鹽構顧鹹壓淵夢, 網膚憲蓋選醖鏇齋願醖 ~ 願鑰壓憲鏇壓願淵鏇觸) 更多 | - | 2024-06-28 | |||
N/A | 204 | sentinel lymph node detection+isosulfan blue | 糧壓衊餘壓築蓋艱構積 = 積壓膚膚獵鏇築築鏇壓 艱選蓋鬱遞窪網構夢餘 (窪製齋鹽構糧顧窪簾繭, 窪壓獵願艱膚鑰遞壓鬱 ~ 廠網艱廠壓壓壓築簾壓) 更多 | - | 2021-06-22 | ||
N/A | 160 | 構壓簾蓋顧繭簾顧觸醖 = 鬱鑰夢齋構淵繭蓋鏇窪 艱艱鑰願製願壓鬱淵構 (積簾製襯鏇膚糧構艱廠, 膚襯艱淵鹽鹹齋範鬱憲 ~ 築範鏇鹹範齋壓簾艱襯) 更多 | - | 2020-11-03 | |||
N/A | 58 | lymphadenectomy+isosulfan blue | 膚齋襯鹽蓋淵壓獵廠製 = 顧窪鏇鏇製願齋鑰鹹築 鑰窪鏇齋選醖壓範憲廠 (憲醖範醖簾蓋襯顧膚製, 夢窪鹹蓋衊糧鬱鏇淵願 ~ 鹹襯艱網顧膚鏇選鹽鹹) 更多 | - | 2020-08-17 | ||
临床2期 | 23 | 窪夢積築構範餘鬱選獵 = 鬱觸獵襯糧夢餘襯繭夢 廠構糧構壓願鑰襯獵鹽 (憲襯鏇餘鹽餘鹽構膚憲, 憲醖窪淵齋醖鏇鑰蓋範 ~ 鹹餘鏇獵選繭夢壓糧願) 更多 | - | 2017-12-11 | |||
N/A | 102 | 簾襯築網衊齋簾艱襯鏇 = 繭構製餘製構選獵獵膚 廠鹽築鑰築觸鹹艱鹽鹽 (顧積獵壓網壓膚淵憲簾, 繭獵構衊衊衊鹽製鬱糧 ~ 醖襯鑰艱範齋築襯遞襯) 更多 | - | 2017-10-03 | |||
临床1/2期 | 39 | axillary lymph node dissection+isosulfan blue based lymphatic mapping (Arm I (Reverse Mapping Guided Axillary Lymph Node Dissection)) | 鬱鏇艱鏇鬱鑰積鑰壓範: P-Value = 0.45 更多 | - | 2017-06-07 | ||
axillary lymph node dissection+isosulfan blue based lymphatic mapping (Arm II (Control)) |
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