重组干扰素α-2b/苯海拉明(Recombinant interferon alfa-2b/Diphenhydramine) - 药物靶点：H1 receptor x IFNAR_在研适应症：结膜炎_专利_临床

概要

基本信息

药物类型

干扰素

别名

2-(benzhydryloxy)-N,N-dimethylethylamine、2-diphenylmethoxy-N,N-demthylethanamine、Diphenhydramine

+ [6]

靶点

H1 receptor x IFNAR

作用方式

反向激动剂、激动剂

作用机制

H1 receptor反向激动剂(组胺H1受体反向激动剂)、IFNAR激动剂(干扰素α/β受体复合体激动剂)

治疗领域

眼部疾病

在研适应症

结膜炎

非在研适应症-

原研机构

Firn M Zao

在研机构

Firn M Zao

非在研机构-

权益机构-

最高研发阶段批准上市

首次获批日期

俄罗斯 (2008-10-01),

结膜炎

最高研发阶段(中国)-

特殊审评-

登录后查看时间轴

结构/序列

分子式C17H21NO

InChIKeyZZVUWRFHKOJYTH-UHFFFAOYSA-N

CAS号58-73-1

关联

26

项与重组干扰素α-2b/苯海拉明相关的临床试验

IRCT20130304012695N13

/ Recruiting临床2/3期IIT

Infiltration of Diphenhydramine versus subcutaneous Lidocaine at the wound site to reduce pain after open renal surgeries

开始日期2022-07-11

申办/合作机构

Tehran University of Medical Sciences

IRCT20210228050519N1

/ Recruiting临床3期IIT

Evaluation of the effect of three compounds (nystatin, aluminum ammonia, and diphenhydramine), mouthwash, chamomile, and mucosamine spray in the treatment of chemotherapy-induced oral mucositis in malignancy in children with leukemia

开始日期2021-12-21

申办/合作机构

Arak University of Medical Sciences

NCT05036174

/ Unknown statusN/AIIT

Diphenhydramine 5% Ointment for Pain in Knee Osteoarthritis: a Randomised Double-blind Placebo-controlled Pilot Feasibility Study

The main purpose of this study is to evaluate whether recruitment rates are adequate to power a future RCT. The secondary aims are to obtain preliminary information about safety and efficacy of topical diphenhydramine 5% ointment in patients with knee OA.

开始日期2021-09-01

申办/合作机构-

100 项与重组干扰素α-2b/苯海拉明相关的临床结果

登录后查看更多信息

100 项与重组干扰素α-2b/苯海拉明相关的转化医学

登录后查看更多信息

100 项与重组干扰素α-2b/苯海拉明相关的专利（医药）

登录后查看更多信息

8,482

项与重组干扰素α-2b/苯海拉明相关的文献（医药）

2025-07-01·Separation and Purification Technology

Complete antihistamine degradation in wastewater matrix using a metal-free N-doped carbon with superior electrocatalytic performance for in-situ H2O2 production

作者: Zhao, Lele ; Durante, Christian ; Mazzucato, Marco ; Parnigotto, Mattia ; Lanzalaco, Sonia ; Sires, Ignasi ; Cabot, Pere L.

A new gas-diffusion electrode (GDE) has been developed and optimized to apply the heterogeneous electro-Fenton (EF) process to the degradation of the antihistamine diphenhydramine.The complete removal of this hazardous drug pollutant was achieved within only 120 min in actual urban wastewater at pH 5.9.Nitrogen-doped carbon electrocatalysts were first synthesized by direct pyrolysis of blends of com. Vulcan carbon and melamine as nitrogen dopant.A radar chart was proposed to correlate the tested physicochem. and electrochem. properties.A well-balanced surface area, mesopores volume and defective carbon content were critical to ensure the highest activity (E_onset = 0.38 V vs. RHE) and selectivity (n ∼ 2, y_H2O2 ∼ 95.3 %) for two-electron oxygen reduction reaction (ORR), which allowed the efficient in-situ production of H₂O₂ as ^·OH precursor.N-doping (10.5 wt%), along with the presence of pyrrolic N (3.5 %), are also key factors to explain the enhancement.GDEs fabricated with the optimal electrocatalyst (71.4 wt% melamine content) were capable of accumulating up to ∼35 mM H₂O₂ within 5 h, outperforming the com. GDEs.This work evidences the interplay of physicochem. and electrocatalytic parameters in H₂O₂-based advanced water treatment, demonstrating that it is possible to envisage a more efficient and greener tertiary wastewater treatment.

2025-06-01·Food Chemistry

High-throughput screening of new psychoactive substances and related compounds in food by UHPLC-Q/Orbitrap

Article

作者: Wu, Wenlin ; Huang, Xia ; Liu, Shiyao ; Chen, Xiaoqi ; Zhou, Yan ; Wan, Yuping ; Xia, Bing ; Guo, Tianrong ; Shi, Peiyu ; Xiao, Quanwei ; Zhang, Min

Currently, there is concern about food products to which new psychoactive substances (NPS) have been added illegally. However, rapid, high-sensitivity, and high-throughput screening methods for such harmful substances have not been reported yet. In this study, a high-throughput non-targeted screening strategy was developed based on UHPLC-Q/Orbitrap. First, optimized pretreatment methods for typical high-risk matrices were established. Second, an accurate, efficient, and scalable high resolution mass spectrometry database containing 206 NPS and related compounds was constructed. The fragmentation pathways of three different types of fentanyl-related compounds were then systematically investigated to enhance compound identification. Additionally, a non-targeted screening strategy was developed using warning ions derived from 24 fentanyl-related compounds, streamlining the identification of NPS. This strategy was applied to 100 food samples with possible illegal additives and demonstrated its effectiveness. In summary, this study provides robust technical support for regulatory authorities in combating the illegal addition of food products.

2025-05-01·Skeletal Radiology

Correction to: Rhabdomyolysis following diphenhydramine overdose—a case report

作者: Karatas, Rifat ; Silva, Flavio Duarte ; Taneja, Atul Kumar ; Basha, Adil ; Chhabra, Avneesh

100 项与重组干扰素α-2b/苯海拉明相关的药物交易

登录后查看更多信息

外链

KEGG	Wiki	ATC	Drug Bank
-	重组干扰素α-2b/苯海拉明	R06AA52	DB01075

研发状态

10 条最早获批的记录,

登录

后查看更多信息

适应症	国家/地区	公司	日期
结膜炎	俄罗斯	Firn M Zao	2008-10-01

登录后查看更多信息

临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ASN2020	N/A	慢性肾病	353	Allopurinol	繭鬱蓋願衊膚構艱鑰繭(願餘夢窪繭淵遞夢鹽鬱) = 鏇淵憲願鏇遞遞鑰範齋選鑰廠繭衊網顧簾淵鹹 (夢簾鹹獵艱顧壓鑰築衊 ) 更多	不佳	2020-10-19
				Colchicine	繭鬱蓋願衊膚構艱鑰繭(願餘夢窪繭淵遞夢鹽鬱) = 築築鬱鬱齋鏇繭遞簾鑰選鑰廠繭衊網顧簾淵鹹 (夢簾鹹獵艱顧壓鑰築衊 ) 更多
AAAAI2014	N/A	-	-	diphenhydramine (Adults)	鏇鹽鏇獵鬱簾艱廠淵選(淵獵齋製衊範鬱憲範選) = 構餘憲獵齋鑰蓋醖醖鹹鏇衊積憲蓋範鏇憲齋膚 (選觸鏇膚憲鹽淵衊積顧 ) 更多	-	2014-02-01
				diphenhydramine (Children)	鏇鹽鏇獵鬱簾艱廠淵選(淵獵齋製衊範鬱憲範選) = 網繭餘艱餘範觸淵糧鹽鏇衊積憲蓋範鏇憲齋膚 (選觸鏇膚憲鹽淵衊積顧 ) 更多
AAAAI2010	N/A	-	-	Cetirizine	窪選壓構鬱簾鏇淵窪壓(醖糧築憲簾淵鹹鏇齋顧) = 鬱網鹽壓憲壓淵鹹襯繭鏇廠廠鬱壓願築鬱簾蓋 (網築網構積鑰構醖構繭 )	-	2010-02-01
				OTC loratadine	窪選壓構鬱簾鏇淵窪壓(醖糧築憲簾淵鹹鏇齋顧) = 顧構範膚襯觸鬱齋鏇觸鏇廠廠鬱壓願築鬱簾蓋 (網築網構積鑰構醖構繭 )